Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyrotropin-releasing hormone (trh)-gly conversion to trh in rat ventral prostate is inhibited by castration and aging. | trh levels in rat prostate are very high in the 2-month-old rat and decline at least 90% during the next 2 yr. this decline in prostatic trh levels with aging may be a significant factor in benign prostatic hypertrophy in man and other animals. because prostatic trh correlates positively with serum testosterone and negatively with serum thyroid hormone levels, we have examined the possibility that the age-related decline in prostatic trh is hormonally regulated. trh and a trh precursor peptide, ... | 1989 | 2502375 |
| recognition and binding of template-primers containing defined abasic sites by drosophila dna polymerase alpha holoenzyme. | human dna polymerase alpha holoenzyme follows an ordered sequential terreactant mechanism of substrate recognition and binding (wong, s. w., paborsky, l. r., fisher, p. a., wang, t. s.-f., and korn, d. (1986) j. biol. chem. 261, 7958-7968). we confirmed this mechanism for the dna polymerase alpha holoenzyme purified from drosophila melanogaster embryos and studied the interaction of drosophila pol alpha with synthetic oligonucleotide template-primers containing modified tetrahydrofuran moieties ... | 1989 | 2502545 |
| the structure and serologic distribution of an extracellular neutral polysaccharide from pseudomonas aeruginosa immunotype 3. | previous work has described small molecular weight neutral polysaccharides from isolates of pseudomonas aeruginosa that appear to be associated with the lipopolysaccharide (lps) and distributed across serologic barriers defined by antibody to the o side chain. we have isolated and characterized another of these structures obtained from culture supernatants of an immunotype 3 strain of p. aeruginosa. the isolated neutral polysaccharide has a tetrasaccharide repeat unit: (formula; see text) where ... | 1989 | 2504722 |
| difference in catalepsy response in inbred rats during chronic haloperidol treatment is not predictive of the intensity of behavioral hypersensitivity which subsequently develops. | an animal model was utilized to explore the observed clinical association between a history of significant neuroleptic-induced parkinsonism and an increased incidence for the subsequent development of tardive dyskinesia. catalepsy-sensitive fisher rats and catalepsy-resistant brown norway rats were treated for 14 days with haloperidol at a dose of either 1 mg/kg or 5 mg/kg daily. following a 7-day drug withdrawal period, rats were tested for behavioral hypersensitivity to acute challenge with ap ... | 1989 | 2505286 |
| blockade of conditioned avoidance responding by trazodone, etoperidone, and mcpp. | phenylpiperazines, such as meta-chlorophenylpiperazine (mcpp) a serotonin agonist, have recently been reported to block conditioned avoidance responding (car) in the rat, which is an indication of possible antipsychotic utility. since mcpp is a major metabolite of both antidepressant drugs trazodone (tz) and etoperidone (et), both were examined for activity in blocking car in a single-trial lever press task in fisher 344 rats. both tz and et produced dose-related falls in car with ed50 values (9 ... | 1989 | 2506609 |
| growth hormone (gh) secretion in the pituitary-grafted male rat: in vivo effects of gh-releasing hormone and isoproterenol and in vitro release by individual somatotropes. | although the pituitary-grafted rat is a classic model of chronic prl excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for gh secretion. the current study was designed to investigate gh-releasing hormone (grh)-induced gh secretion and beta-adrenergic inhibition of gh release in animals bearing ectopic pituitary tissue free from hypothalamic control. positive findings with regard to these in vivo experiments led us to an initial determination of gh secretion b ... | 1989 | 2507290 |
| lectin typing of pseudomonas aeruginosa strains of different serogroups, habs and fisher types. | sixteen habs and three fisher types of pseudomonas aeruginosa were typed with lectins of know specificity resulting from their interaction with bacterial cell surface carbohydrates as evidenced by agglutination-inhibition assay with simple carbohydrates. lipopolysaccharides of few strains of pseudomonas are precipitated with different lectins and the results are corroborated by those of agglutination suggesting that pseudomonas aeruginosa can be characterized intraspecifically by lectins. | 1989 | 2508658 |
| isolation and characterization of a human monoclonal antibody that recognizes epitopes shared by pseudomonas aeruginosa immunotype 1, 3, 4, and 6 lipopolysaccharides. | a hybridoma line secreting a human monoclonal antibody (hmab) capable of recognizing fisher immunotype (it) 1, 3, 4, and 6 lipopolysaccharide (lps) in vitro was isolated. peripheral blood lymphocytes (pbl) were obtained from volunteers immunized with an experimental pseudomonas aeruginosa o polysaccharide-toxin a vaccine. pbl-expressing surface antibodies able to bind to p. aeruginosa lps were isolated by adsorption onto lps-coated plastic wells. such pbl were transformed with epstein-barr virus ... | 1989 | 2509371 |
| sarcocystis sp. in mountain goats (oreamnos americanus) in washington: prevalence and search for the definitive host. | during october and november 1986, sarcocystis sp. was detected in 24 of 56 (43%) tongues from hunter-killed mountain goats (oreamnos americanus) in washington (usa). sarcocysts had an unusual sessile polyp-shaped branched wall. mean size of 154 sarcocysts was 71.3 x 37.8 microns (range, 20 to 248 x 10 to 120 microns), and the mean intensity was 2.3 (range, 1 to 28). in an attempt to identify the definitive host, infected tongues were fed to four coyotes (canis latrans), eight domestic dogs, four ... | 1989 | 2509738 |
| [specific intoxication in anthrax infection]. | the pathomorphological picture of experimental b. anthracis infection in white rats (strain fisher-344) essentially corresponds to experimental anthracic intoxication with very moderately pronounced morphological manifestation of b. anthracis invasion. this indicates that specific anthracic intoxication is an essential component of the pathological process in b. anthracis infection. | 1989 | 2511710 |
| effects of diethylstilboestrol on testicular function and luteinizing hormone receptors. | adult male fisher-344 rats were implanted with des-filled or empty silastic capsules. after 14 weeks, capsules were removed and a second group of rats received des capsules. seven weeks later, all the rats were sacrificed. des treatment decreased body, testes and seminal vesicle weights, and removal of the capsules partially restored the weight of these organs. the concentration of testicular lh receptors was increased by des treatment. circulating prl levels were increased and gonadotropin leve ... | 1989 | 2515561 |
| [results of cross-species transplantation of substantia nigra to the lateral ventricle of the brain of rats with experimentally-induced parkinson disease]. | the method of compensation of dopamine (da) deficit in the striatum by living, da producing cells implanted into the brain, creates new hopes for patients with parkinson's disease. in view of many ethical and legal problems, connected in some countries with obtaining human fetal tissue for transplantation, cross-species transplants would be an attractive alternative. the subject of our investigation was the problem of survival and functioning of embryonal substantia nigra (sn) neurons, taken fro ... | 1989 | 2518574 |
| the calmodulin binding domain of the plasma membrane ca2+ pump interacts both with calmodulin and with another part of the pump. | synthetic peptides corresponding to the calmodulin-binding domain of the human erythrocyte ca2+ pump were prepared representing residues 2-29 (c28w), 2-21 (c20w), 2-16 (c15w), and 16-29 (c14) of the sequence (james, p., maeda, m., fisher, r., verma, a. k., krebs, j., penniston, j. t., and carafoli, e. (1988) j. biol. chem. 263, 2905-2910). peptides c28w, c20w, and c15w bound to calmodulin with an apparent 1:1 stoichiometry in the presence of ca2+ and inhibited the activation of the ca2+ pump by ... | 1989 | 2526124 |
| interleukins production and responsiveness in fisher rats with adjuvant-induced disease: role of suppressor cells. | splenic macrophages from aid fisher rats produce normal levels of il-1, in contrast to il-2 which is significantly lower than normal. a state of hyporesponsiveness of spleen cells to con-a and pha occurs with similar kinetics to and is correlated with the development of an articular arthritis; il-1 addition to aid spleen cell cultures does restore to normal their deficient response, in contrast to addition of il-2 or ril-2. the spleen cells from normal or aid rats are equally sensitive to the in ... | 1989 | 2526223 |
| complementation of enteric adenovirus type 40 for lytic growth in tissue culture by e1b 55k function of adenovirus types 5 and 12. | the enteric adenovirus type 40 strain dugan (ad40) cannot be passaged in hela cells, but will grow in 293 cells, which express ad5 e1 functions. to determine the reason for this limited host range, kb cell lines expressing ad2 e1a, e1b, or e1a + e1b (l. e. babiss, c. s. h. young, p. b. fisher, and h. s. ginsberg, 1983, j. virol. 46, 454-465) have been tested for their ability to support ad40 replication. only cell lines which supply e1b functions, but not those expressing e1a alone, are permissi ... | 1989 | 2527440 |
| functional analysis of lymphocytes subpopulations in experimental cocaine abuse. i. dose-dependent activation of lymphocyte subsets. | the potential role of substance abuse, especially cocaine and alcohol as co-factor in hiv infection and in the development and expression of aids has been suggested, but the possible biological role of substance abuse in the development of aids is not known. in order to better understand immune system function in chronic cocaine abuse, we have assessed primary b cell responses to helper t-cell independent (ti) and dependent (td) antigens in inbred fisher male rats injected with 1.25-5 mg cocaine ... | 1989 | 2528433 |
| effect of cyproterone acetate in comparison to flutamide on the ventral prostate of adult male castrated copenhagen-fisher rats and on dunning r-3327 h tumors. | in this investigation the effect of cpa was tested in comparison to fl after the procedure of double blinding on the ventral prostate of 70 adult male castrated copenhagen-fisher rats and on the dunning r-3327 h tumor. total androgen blockade by castration plus cpa or by castration plus fl induced significant decrease in prostate weight compared to the androgen deprivation by castration alone. no significant difference between cpa and fl was observed. furthermore it was impossible to exaggerate ... | 1989 | 2530921 |
| normal brain tissue response to photodynamic therapy: histology, vascular permeability and specific gravity. | the response of photodynamic therapy on normal brain was investigated in 140 fisher rats. the rats were injected i.p. with photofrin ii (12.5 mg/kg) and 48 h later the dural area over the frontal cortex was photoactivated with red light (630 +/- 1 nm) from an argon dye laser. treatment was performed with optical energy densities of 140 and 70 j/cm2. histopathology, vascular permeability and specific gravity measurements were conducted on different populations of rats at 4 h, 24 h, 72 h and 1 wee ... | 1989 | 2533693 |
| immunological functions in food-restricted rats: enhanced expression of high-affinity interleukin-2 receptors on splenic t cells. | several immunological functions of b and t cells including il-2 receptor expression on t cells were measured in 12-month-old fisher-344 male rats maintained from 6 weeks of age on an ad libitum (al) or a 40% food-restricted (fr) diet. direct anti-srbc plaque-forming cell (pfc) assays revealed a higher response in fr rats than in al rats when splenocytes were cultured with or without recombinant interleukin-2 (ril-2). b cell functions were studied by using nylon wool-purified splenic b cells stim ... | 1989 | 2534390 |
| triethyllead-induced peroxidative damage in various regions of the rat brain. | adult male fisher 344 rats (8-10 wk old) were dosed ip with 1.75 mg/kg body weight of triethyllead chloride (tel) for 5 consecutive days. rats were sacrificed 1, 7, or 21 d after the last injection. the rate of lipid peroxidation was significantly elevated in frontal cortex at all three time points assayed (1, 7, or 21 d). however, hippocampal and cerebellar membranes showed no changes in peroxidative capacity at these time points. in order to determine whether cortical membrane damage was refle ... | 1989 | 2537905 |
| vip receptors and content after bowel transplantation. | advances in immunosuppressive therapy have renewed interest in small bowel transplantation. little is known, however, about the functional capacity of transplanted intestine. to clarify the potential for normal function, we investigated whether elements of the enteric nervous system are preserved after denervation in our rat model of intestinal transplantation. we investigated whether vip, a major peptide neurotransmitter of the enteric nervous system, and its receptors are preserved in the bowe ... | 1989 | 2541280 |
| diagnostic usefulness of mycobacterial skin test antigens in childhood lymphadenitis. | nontuberculous mycobacterial (ntm) infections are a frequent cause of chronic lymphadenitis in children. previous studies of ntm antigen skin testing were inconclusive as a result of problems with study design and antigen formulation. the present study was undertaken with the centers for disease control to determine whether newly formulated ntm skin test antigens applied in a double blind manner with a standard purified protein derivative could accurately distinguish ntm infections from those ca ... | 1989 | 2541397 |
| fbl-reactive cd8+ cytotoxic and cd4+ helper t lymphocytes recognize distinct friend murine leukemia virus-encoded antigens. | immunization of c57bl/6 (b6) mice with fbl, a friend murine leukemia virus (f-mulv), induces both tumor-specific cytolytic cd8+ (ctl) and lymphokine-producing cd4+ th that are effective in adoptive therapy of b6 mice bearing disseminated fbl leukemia. the current study evaluated the f-mulv antigenic determinants expressed on fbl that are recognized by fbl-reactive cd8+ and cd4+ t cells. to identify the specificity of the fbl-reactive cd8+ ctl, fisher rat embryo fibroblast (fre) cells transfected ... | 1989 | 2562982 |
| [ergonomic analysis of the work sites and living conditions of the crew on board the b-418/111 t/h "bonito" ppd and ur "gryf" fishing trawlers]. | the paper is an ergonomic study of the sanitary and living conditions at the working place of fishers on long-distance fishing vessels, such as the trawler b-418/111 t/h "bonito". the research was performed during the trip in the region of the falkland islands (malvinas). prophylactic examinations were carried out during 162 days on 77 members of the crew and the hygienic-sanitary conditions on the vessel were analysed. the ergonomic research included all the working places of the members of the ... | 1989 | 2571193 |
| activation of a ribosomal s6 protein kinase in rapidly emerging diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive hyperplastic liver lesions of the rat. | the gamma-glutamyl transpeptidase (ggt)-positive hyperplastic liver lesions which developed in the fisher 344 rat 7 and 60 days following a single carcinogenic dose of diethylnitrosamine (dena, 200 mg/kg body weight), short-term dietary exposure to 0.02% 2-acetylaminofluorene (aaf) to suppress the growth of normal hepatocytes, and partial hepatectomy to actuate rapid growth of dena altered hepatocytes not suppressed by aff, showed an increased activity of a kinase which specifically phosphorylat ... | 1989 | 2575815 |
| retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium. | lipofuscin in the retinal pigment epithelium (rpe) is thought to be derived from phagocytosed photoreceptor outer segment disc membranes. based on this hypothesis, one would predict that the rate of lipofuscin deposition in the rpe would be proportional to the density of photoreceptor cells in the retina. in previous studies it was demonstrated that specific loss of photoreceptor cells due to a genetic defect resulted in a substantial decrease in the rate of age-related lipofuscin accumulation i ... | 1989 | 2912913 |
| calculation of transmitral flow by doppler echocardiography: a comparison of methods in a canine model. | although several doppler echocardiographic methods for measuring transmitral flow have been described, the optimal method for calculation of flow remains unclear. seven time/shape combinations were tested in an experimental preparation in which mitral flow could be precisely controlled and measured. annular shape was considered to be either circular or elliptical, and the mitral orifice area was calculated from the anteroposterior and/or the mediolateral dimension(s) recorded at early and middia ... | 1989 | 2916413 |
| response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure. | the purpose of this study was to evaluate the in vivo effects of an acute exposure to low levels of ozone on rat pulmonary alveolar macrophages (pam). fisher 344 rats exposed to 0.0, 0.12, 0.8, or 1.5 ppm o3 for 6 h were killed immediately after and 3, 18, 42, or 66 h after ozone exposure and their lungs were lavaged. compared to sham-exposed (control) rats, exposure to 0.12 ppm o3 had no measurable effect on the total number, labeling index (li), mitotic index (mi), or morphology of rat alveola ... | 1989 | 2917543 |
| some simple methods for linkage analysis. | a method of analysis of suitable many-locus linkage data used by fisher in 1922 is re-examined in detail, and it is pointed out that it could be used also in human genetics as a simple method for preliminary examination of data. | 1989 | 2596834 |
| alteration of tissue magnesium levels in rats by dietary vitamin b6 supplementation. | tissues from female fisher rats fed varying levels of magnesium (100 ppm or 700 ppm) and pyridoxine hydrochloride (pn.hcl) (7, 35, or 1500 mg/kg diet for six weeks) were dry ashed and analyzed for magnesium using atomic absorption spectroscopy. in tissues from rats consuming magnesium diets, tissue magnesium levels increased as levels of dietary pn.hcl increased. increases in plasma, liver, kidney, and brain magnesium levels were statistically significant (p less than 0.05). with the exception o ... | 1989 | 2599796 |
| cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes. | 1. we have previously shown that the capacity for specific binding of human 125i-labelled low-density lipoprotein (ldl) to rat hepatocytes increases with time in culture [salter, bugaut, saxton, fisher & brindley (1987) biochem. j. 247, 79-84]. 2. in the present study we show that this up-regulation is accompanied by a rise in the cholesterol ester content of the cells. 3. inhibition of cholesterol esterification with the drug 58-035 (sandoz) significantly decreases the time-dependent 'up-regula ... | 1989 | 2604696 |
| changes of blood flow in the adenohypophysis of normal and estrogen pretreated fisher rats by tamoxifen. | blood flow was measured in the adenohypophysis and in the cerebral cortex of female f344 rats over a period of 90 min using the hydrogen clearance method. tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing ... | 1989 | 2609903 |
| comparative cariogenicity and dental plaque-forming ability in gnotobiotic rats of four species of mutans streptococci. | the four species, each represented by two strains, all produced high levels of fissure caries in the upper and lower jaws of gnotobiotic fisher rats. streptococcus rattus strains and streptococcus mutans nctc 10832 gave low levels of approximal caries, whereas streptococcus cricetus, streptococcus sobrinus and strep. mutans nctc 10449 gave high levels. the only strains to produce buccal surface lesions were strep. sobrinus and strep. cricetus. all strains were able to form dense plaque in the ce ... | 1989 | 2610617 |
| iodination of newly synthesized thyroglobulin by frtl-5 cells is selective and thyrotropin dependent. | this study shows that the fisher rat thyroidal cell line (frtl-5) can iodinate newly synthesized thyroglobulin. iodinated thyroglobulin was found intra- and extracellularly. both the synthesis of thyroglobulin and its subsequent iodination were found to be thyrotropin (tsh) dependent, with optimal activity at 10-100 microu tsh/ml. thyroglobulin was the only protein in the culture medium, that was iodinated with high specificity and in a tsh-dependent fashion. albumin, which was abundantly presen ... | 1989 | 2612732 |
| anatomical and functional effects of estrogen-induced prolactinomas on the rat hypothalamus. | although estrogen-induced prolactinomas have been widely studied, little attention has been accorded to local pressure effects of the tumor on the hypothalamus and portal vasculature. to portray the magnitude of this phenomenon, four groups of 12-13-week-old female fisher 344 rats were studied. group 1 was an intact control receiving a subcutaneously (sc) placed placebo pellet; group 2 was an ovariectomized control with a sc placed placebo pellet; group 3 was ovariectomized with a 10 mg sc place ... | 1989 | 2614531 |
| the effect of marijuana smoke exposure on murine sarcoma 180 survival in fisher rats. | fisher rats were treated for 28 or 60 days to multiple exposures to the smoke of marijuana or marijuana placebo cigarettes. primary, secondary and in some instances tertiary tumor implants were performed. murine sarcoma 180 tumor cells (7.5 x 10(7)) were implanted subcutaneously on day 1, 14 and 28 following initiation of smoke exposure (28 day studies) or on day 1, 14 after cessation of smoke exposure (60 day studies). tumor areas were measured on alternate days beginning on the second or third ... | 1989 | 2621317 |
| phorbol esters and forskolin infused into midbrain central gray facilitate lordosis. | several peptides, when infused into the mcg, facilitate lordosis in estrogen-primed female rats. since these peptides can act through camp and/or protein kinase c, and these second messenger systems have been implicated in neuromodulation, this study examined if pharmacological agents which stimulate these systems would facilitate lordosis. ovariectomized female fisher rats were given bilateral cranial cannulae targeted to the mcg, or cortex dorsal to mcg, and allowed at least a week to recover. ... | 1989 | 2623023 |
| evaluation of cortisone-heparin and cortisone-maltose tetrapalmitate therapies against rodent tumors. i. biological studies. | the antitumor activity of either cortisone-heparin or cortisone-maltose tetrapalmitate combination or both was tested against two animal tumor models. the first model was orthotopically implanted bladder tumor established in syngeneic fisher 344 rats. shrinkage and growth arrest of the tumors were induced by cortisone and amplified by its combination with either heparin or maltose tetrapalmitate (mtp). the second model was trocar implanted c3hba mammary tumor piece s.c. in syngeneic lps and mtp ... | 1989 | 2627134 |
| evaluation of cortisone-heparin and cortisone-maltose tetrapalmitate therapies against rodent tumors. ii. pathological studies. | pathological studies were undertaken in three tumor-host models which were subjected to cortisone based treatments. the first model was fisher 344 rats with established orthotopically implanted syngeneic bladder tumor. cortisone-herapin and cortisone-maltose tetrapalmitate (mtp) treatments induced focal areas of tumor necrosis and necrobiosis, whereas cortisone alone caused necrobiosis. the second model was c3hba mammary tumor fragments implanted subcutaneously in syngeneic mtp responder c3h/hen ... | 1989 | 2627135 |
| natural killer cell activity in rats infused with intralipid. | the effect of intralipid on the natural killer (nk) cell activity of healthy male fisher 344 adult rats was investigated. they were cannulated via the right jugular vein and continuously infused for five days with: normal saline plus heparin, 5% intralipid plus heparin, or 10% intralipid plus heparin. control groups comprised of cannulated rats receiving no infusion and rats undergoing no operative procedures. following the five-day infusion, rats were exsanguinated under ether anesthesia and mo ... | 1989 | 2628583 |
| endogenous glutamate release from frontal cortex of adult and aged rats. | glutamate (glu) is a major excitatory neurotransmitter in the frontal cortex. alterations in glu neurotransmission are present in a number of neurodegenerative diseases, however, little is known about the normal aging process of glu utilizing neurons. glu release, uptake and content were examined in the frontal cortex of adult (6 months old) and aged (24 months old) male, fisher 344 rats. these markers were used to assess the functional integrity of intrinsic and extrinsic glu utilizing pathways ... | 1989 | 2628777 |
| correlation between liver iron content and magnetic resonance imaging in rats. | currently, serum ferritin concentration is the best noninvasive estimator of liver iron content. this study investigated the ability of magnetic resonance imaging to determine hepatic iron concentration. fisher rats were treated with either parenteral iron to increase levels of phlebotomy to lower them and achieved a wide range of liver iron concentrations. rats were imaged using a clinical whole body scanner at 1.5 tesla with a 15-cm helmholtz surface coil and a 23-cm field of view. the ratio o ... | 1989 | 2630845 |
| [morphofunctional transformations of the blood vessels in the transplantation of syngeneic normal tissue and of a tumor]. | in 360 fisher rats dynamics of changes in blood vessels, the microcirculatory bed vessels included, have been investigated. an original model of the experiment at implantation of syngenic tissues of the fetus normal intestine and tumorous adenocarcinoma of the small intestine has been used. specific changes of the blood vessels have been revealed around and in the capsule of the implant, depending on their morphological reorganization. the blood vessels changes can serve as a prognostic sign of ... | 1989 | 2631644 |
| stress ulcer susceptibility and depression in wistar kyoto (wky) rats. | in a series of studies, wistar kyoto (wky) normotensive rats were more susceptible to water-restraint-induced stress ulcer as compared to spontaneously hypertensive rats (shr) fisher-344 (f344) and wistar rats. in these same studies, wky rats were also deficient in several behavioral tasks. the four strains were observed in the open-field test of emotionality and wkys were judged more emotional. in a study on "learned helplessness" wkys were more deficient in the acquisition of a shuttlebox esca ... | 1989 | 2634265 |
| the neutrophil-activating protein (nap-1) is also chemotactic for t lymphocytes. | t lymphocyte chemotactic factor (tcf) was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence of chromatography procedures. the amino-terminal amino acid sequence of the purified tcf showed identity with neutrophil-activating protein (nap-1). both tcf and recombinant nap-1 (rnap-1) were chemotactic for neutrophils and t lymphocytes in vitro supporting the identity of tcf with nap-1. injection of rnap-1 into lymphati ... | 1989 | 2648569 |
| cryopreservation does not alter antigenic expression of aortic allografts. | cryopreserved aortic homografts are reportedly viable, but no cross-matching or immunosuppression is utilized. alterations of the antigenic expression by cryo-preservation must be assumed. we designed a protocol to test this premise. fisher 344 rats served as recipients in all cases. lewis rats, a mildly disparate strain, were utilized as donors. four cohorts of animals were utilized. group i (n = 11) served as a "first set" control. all animals received a syngeneic skin graft. after 28 days an ... | 1989 | 2659897 |
| [neurologic involvement in campylobacter infections. 5 cases]. | campylobacter are a newly recognized class of human infectious agents. campylobacter fetus subspecies fetus is a cause of sepsis in immunocompromized hosts. secondary neurological determinations, meningitis and meningoencephalitis appear to be rare. we report 2 cases, and 8 previously reported cases are reviewed. campylobacter jejuni appears to be a common bacterial pathogen causing a syndrome of enteritis. since 1982 it has been associated with guillain-barré syndrome (gbs). in one serological ... | 1989 | 2664975 |
| length changes in dendritic networks of cerebellar purkinje cells of old rats after chronic ethanol treatment. | dendritic networks of cerebellar purkinje neurons from aging ethanol-treated fisher 344 rats were analyzed for metric changes in terminal and internal segments of the networks. mean lengths of three categories of dendritic segments were determined. no significant metric changes in segment lengths were detectable immediately at the termination of 24 weeks of ethanol treatment, but significant changes were apparent after 8 weeks of recovery from ethanol treatment. return to a diet of standard labo ... | 1989 | 2665558 |
| molecular biology of friend viral erythroleukemia. | friend virus clearly provides an important model for understanding the molecular biology of cancer. moreover, the most important aspects of the erythroleukemia can be caused by a single sffv infection in the absence of any helper virus. the sffv env gene encodes a membrane glycoprotein, gp55. this glycoprotein, when expressed on erythroblast surfaces, causes a constitutive mitogenesis. however, sffv infections only rarely increase the cell's self-renewal capability or abrogate its commitment to ... | 1989 | 2684547 |
| putidaredoxin competitively inhibits cytochrome b5-cytochrome p-450cam association: a proposed molecular model for a cytochrome p-450cam electron-transfer complex. | cytochrome b5 has been genetically engineered to afford a fluorescent derivative capable of monitoring its association with cytochrome p-450cam from pseudomonas putida [stayton, p. s., fisher, m. t., & sligar, s. g. (1988) j. biol. chem. 263, 13544-13548]. in the mutant cytochrome b5, threonine is replaced by a cysteine at position 65 (t65c) and has been labeled with the environmentally sensitive fluorophore acrylodan. in this paper, the physiological p-450cam reductant putidaredoxin, an fe2s2.c ... | 1989 | 2690937 |
| mechanisms involved in the pathogenesis of yersinia infections. | yersinia enterocolitica and yersinia pseudotuberculosis are food-borne enterobacterial pathogens which may initiate rheumatoid diseases. by molecular genetic analysis of the pathogenicity of these species virulence gene loci could be identified on the chromosome and on a plasmid. plasmid-encoded proteins mediate cell adherence, phagocytosis resistance, survival in serum, cytotoxicity, and collagen binding. y. enterocolitica of serotype 0:8 is mouse-lethal and arthritogenic for lewis rats. mouse ... | 1989 | 2692128 |
| augmentation of the resistance against escherichia coli by oral administration of a hot water extract of chlorella vulgaris in rats. | in previous studies, we demonstrated that a hot water extract of chlorella vulgaris (cve) augmented the resistance against an intraperitoneal infection with escherichia coli by its intraperitoneal, intravenous or subcutaneous administration. the augmented resistance appeared to be attributable to the enhanced activity of polymorphonuclear leukocytes (pmn). in this study, the effect of oral administration of cve against escherichia coli infection was examined. male fisher rats (f344/ducrj) were a ... | 1989 | 2693376 |
| the need for a search for a proximal pathogenic principle of human aids. | some of the unexplained aspects of hiv/aids epidemiology, virology, and pathology (6, 13) may thus be due to a lack of knowledge of the basic virology of the virus complex and its pathological interaction with cells of the host. there may be no need to call upon anomalous immune responses, vicious transactivating activities, or new virological or biological principles if we can first do the basic virology of the disease-inducing viruses. while we do not want to propose that working out the virol ... | 1989 | 2702660 |
| structural characterization of nitrimyoglobin. | nitrimyoglobin was formed in greater than 94% yield by a simple reaction between excess nitrite and horse heart metmyoglobin at ph 5.5. this dark green pigment was shown by 1h nmr spectroscopy to be a single, pure product with a well defined tertiary structure that is highly similar to the starting myoglobin. electronic spin states parallel those of myoglobin, although the relaxation times differ. ligand binding reactions of nitrimyoglobin parallel those of normal myoglobin, but lead to a unique ... | 1989 | 2703482 |
| new sensitizers for photodynamic therapy: controlled synthesis of purpurins and their effect on normal tissue. | purpurins are a class of porphyrin derivative that have been shown to have good in vivo cytotoxicity to n-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (fanft) induced rat bladder tumors (ay-27) implanted into fisher 344 rats. the synthesis of purpurins from etioporphyrin i and coproporphyrin i proceeds in high yield and with a high degree of regioselectivity. product formation can be rationalized in terms of relief of steric strain about the periphery of the purpurin macrocycle. the effect of ther ... | 1989 | 2704035 |
| [expression of cell surface transformation-associated antigens taas on activated oncogene-transfected rat fibroblast and antitumor immunity by hosts]. | the key point in this study was that the cell surface antigens in the events of transformation were analyzed using the same clonal-derived nontransformed cell and various oncogenes. wka rat fetus-derived fibroblast line, wfb, showed the strict non-transformant phenotypes. transfection of ejras and polyoma middle t oncogenes into wfb resulted in the acquisition of tumorigenicity in vitro and in vivo. the newly expressed cell-surface antigens on some transformants were analyzed using four monoclon ... | 1989 | 2705790 |
| comparative studies of radiotracer citrates in oncological models--2. 153sm-citrate and 67ga-citrate. | 153sm-citrate solutions were prepared from enriched 152sm2o3 which had been irradiated at 10(12)n cm-2 s-1 in the university of alberta slowpoke reactor. 153sm was rapidly bound (93% in 2 h) by melanoma 2ab cells in tissue culture upon incubation in the presence of 153sm-citrate (1.9 nmol 10(6) cells). in vitro ultracentrifugation studies of 153sm-citrate solutions showed that colloid formation under incubation conditions could have been responsible in part for the uptake by cultured cells. low ... | 1989 | 2714996 |
| age-related alterations in duodenal calcium transport rate in rats. | to determine the age-related alterations in intestinal calcium transport under in vitro controlled conditions, we studied the calcium transport across duodenal segments of prepubertal (2 months), young adult (6 months) and aged (26 months) fisher 344 male rats using the ussing chamber technique. we also evaluated the effect of 10(-11) m 1,25-dihydroxycholecalciferol [1,25-(oh)2d3] in tissue bathing media. the calcium transport rate from mucosa-to-serosa (jms) and from serosa-to-mucosa (jsm) in 2 ... | 1989 | 2716368 |
| changes in the hepatic perfusion index during the development of experimental hepatic tumours. | a model of microscopic liver tumour has been developed in the fisher rat by intraportal injection of 1.6 x 10(7) walker 256 carcinosarcoma cells. rats were studied at 2, 4 and 6 days after the inoculation of live walker cells. a control group received dead walker cells. no tumour was visible in control groups at 2, 4 and 6 days after inoculation. similarly in rats injected with live cells no tumour was visible at 2 days after inoculation but at 4 and 6 days the percentage hepatic replacement was ... | 1989 | 2720322 |
| membranous glomerulonephritis and the nephrotic syndrome in a patient with landry-guillain-barré-strohl syndrome. | membranous glomerulonephritis and the nephrotic syndrome concurrent with the miller-fisher variant of the landry-guillain-barré-strohl syndrome (lgbs), acute post-infective polyneuritis, is reported in a 49-year-old man. the onset of heavy proteinuria coincided with the development of the neurological disturbance. while immunosuppressive therapy appeared to hasten improvement in the neurological disease, no such improvement occurred in the glomerulopathy. | 1989 | 2728436 |
| purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. | a wide variety of rodent and human tumor cells secrete antigenically related phosphoproteins with molecular weights (mr) of approximately 58,000 (hamster), 62,000 (rat, mouse), 67,000 (human) (senger, d.r. and perruzzi, c.a. (1985) cancer res. 45, 5818-5823). expression of these phosphoproteins is transformation-related; tumor cells produce at least 10-fold or more of this protein as compared to their normal or untransformed counterparts. n-terminal and internal sequences derived from the rat tu ... | 1989 | 2736258 |
| the problem of our common mitochondrial mother. | it has been suggested that the mitochondrial dna (mtdna) of all present-day human beings stems exclusively from one woman who lived about 200000 years ago in africa; examination of the problem by the mathematical theory of random walks supposedly renders alternatives very unlikely. however, a statistical argument first used by fisher indicates that this hypothesis is untenable, at least if the assumptions made by previous workers are accepted. all present-day mtdna might go back to one individua ... | 1989 | 2737664 |
| biodistribution of misonidazole and 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) in rats bearing unclamped and clamped 9l subcutaneous tumors. | the biodistribution of misonidazole (miso) and 1,3bis(2-chloroethyl)-1-nitrosourea (bcnu) was studied using the subcutaneous (s.c.) 9l tumor model in male fisher 344 rats. a transient hypoxia in these tumors was created by clamping the blood supply to the tumor. reoxygenation occurred upon release of the clamp. the plasma and tumor concentrations of miso and bcnu were quantitated by high pressure liquid chromatography. when 12 mg/kg of bcnu was given i.p. without miso, the peak plasma concentrat ... | 1989 | 2745188 |
| morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. | the purpose of this study was to compare microvascular morphometric and hemodynamic characteristics of a tumor and granulating normal tissue to develop quantitative data that could be used to predict microvascular characteristics which would be most likely associated with hypoxia. the dorsal flap window chamber of the fisher 344 rat was used to visualize the microvasculature of 10 granulating and 12 tumor (r3230 ac adenocarcinoma) tissues at 2 weeks following surgical implantation of the chamber ... | 1989 | 2745213 |
| aging: effect on hepatic metabolism and transport of folate in the rat. | effects of aging on hepatic folate metabolism and transport were assessed in male fisher 344 rats. total serum and hepatic folate levels were measured. hepatic folates were measured by high-performance liquid chromatography and by lactobacillus casei assay. transport of 5-methyltetrahydrofolate (5-ch3-h4pteglu) was measured in isolated hepatocytes. serum folate declined with aging; however, neither the total folate level nor the distribution of hepatic folate coenzymes was affected by the aging ... | 1989 | 2756923 |
| treatment of experimental pseudomonas aeruginosa pneumonia with a human igm monoclonal antibody. | a human igm monoclonal antibody (ma-1c1) to fisher immunotype 3 pseudomonas aeruginosa lipopolysaccharide antigen was evaluated for in vivo activity in a guinea pig model of experimental pneumonia. pharmacokinetics of ma-1c1 were compared in infected and noninfected animals. intravenous bolus infusion of ma-1c1, 1 mg/kg, resulted in peak serum antibody concentrations of 3.8 +/- 0.08 and 3.7 +/- 0.05 micrograms/ml in infected and noninfected animals, respectively. serum half-lives were 25 and 22 ... | 1989 | 2760499 |
| changes with aging in the levels of amino acids in rat cns structural elements. ii. taurine and small neutral amino acids. | taurine (tau) and the small neutral amino acids glycine (gly), serine (ser), threonine (thr), and alanine (ala) were measured in 53 brain areas of 3- and 29-month-old male fisher 344 rats. the ratio of highest to lowest level was 34 for tau, 9.1 for thr, 7.6 for gly and ser, and 6.5 for ala. the heterogeneity was found in numerous areas; for example, tau levels were more than 90 nmol/mg protein in 6 areas, and less than 20 nmol/mg protein in 10 areas. similar heterogeneity was found with the oth ... | 1989 | 2761675 |
| expression of a human multidrug resistance gene in ovarian carcinomas. | expression of the human mdr1 gene has been shown to confer the multidrug resistance (mdr) phenotype to sensitive cells. to investigate the possible contribution of the mdr phenotype to chemoresistance in ovarian carcinoma, we have analyzed mdr1 gene expression in fresh carcinoma specimens from 50 patients. fifteen received chemotherapy before surgery and were judged as poor responders. thirty-five patients did not receive any drug before surgery. control tissues were lymphocytes from 7 patients. ... | 1989 | 2766278 |
| chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the fisher 344 rat. | the effect of chloroform (chcl3), administered at 0, 900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (dmh) was investigated. groups of 40 male fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneous injection of 200 mg/kg dmh, a known gastrointestinal (gi) tract carcinogen in this animal strain. when tumors from the gi tract were pooled there was a highly significant (p less than 0.001) decrea ... | 1989 | 2767360 |
| establishment and characterization of an epithelial cell line from the rat submandibular gland. | an epithelial cell line, rsmtx, has been established from the submandibular gland of weanling fisher 344 rats by treatment of explanted tissue clumps with 3-methylcholanthrene. these cells exhibit a polygonal shape on light microscopy and a polar appearance, with desmosomes, terminal bar-like structures, surface microvilli and cytoplasmic interdigitations, when examined by electron microscopy. the cells react positively with an antiserum to cytoskeletal keratin, and a commercial monoclonal antib ... | 1989 | 2769593 |
| correlation of mdr1 gene expression with chemotherapy in neuroblastoma. | forty-one neuroblastoma tumor specimens have been analyzed by northern and slot blot hybridization techniques with human mdr1 gene probes. only one of 15 (6%) tumors from patients who had not received chemotherapy exhibited high levels of mdr1 transcripts, while 11 of 26 (42%) treated tumors showed high levels of mdr1 expression (fisher exact test: p = .03). the results indicate that the level of mdr1 mrna expression is associated with previous chemotherapy, including drugs that select the multi ... | 1989 | 2778826 |
| temporal actions of 16 alpha-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. | 16 alpha-hydroxyesterone (16ohe1), a metabolite of estradiol (e2) and precursor of estriol (e3), binds to the estrogen receptor (er) with low affinity (3% of e2), but is estrogenic in both in vitro and in vivo systems. this metabolite is able to bind in a non-dissociable manner to the er. we examined these properties in vivo by assessing the temporal dynamics of estrogen metabolite action in the rat brain, using lordosis score (ls) to manual stimulation as a serial bioassay of estrogen effect. m ... | 1989 | 2779234 |
| interleukin-1-induced anorexia in the rat. influence of prostaglandins. | the anorexia associated with acute and chronic inflammatory or infectious conditions is poorly understood. our objectives were to explore the anorexigenic effects of interleukin-1 (il-1) in the rat. recombinant human (rh) il-1 beta, murine (rm) il-1 alpha and to a lesser extent rhil-1 alpha significantly reduced food intake at greater than or equal to 4.0 micrograms/kg i.p. but not at lower doses, in young (200-250 g) meal-fed rats on chow diets. the anorexic effect appears to be mediated by pro ... | 1989 | 2786888 |
| effect of magnesium deficiency on interleukin production by fisher rats: effect of interleukins on reduced in vitro lymphocyte responses to concanavalin a and lipopolysaccharide. | the ability of rats fed a magnesium-deficient diet to produce interleukins (ils) and the effect of ils on in vitro lymphocyte mitogenesis have been studied in rats. lack of magnesium resulted in a lower number of plastic-adherent spleen cells and in a reduction of il-1 production. il-2 production was not significantly affected, indicating differential sensitivity of t cells to magnesium deficiency. the diminished mitogenic response of splenocytes to concanavalin a (con-a) was restored by the add ... | 1989 | 2788143 |
| immortalization of rat spleen and thymus t cells by human t-cell leukemia virus type i. | co-cultivation of thymus and spleen cells of fisher and lewis rats with lethally irradiated mt-2 cells harboring human t-cell leukemia virus type i (htlv-i) resulted in the establishment of lymphoid cell lines, firt-1, firs-1, lert-1, and lers-1, respectively. cells of these cell lines had rat t-cell characters as demonstrated by the positive reaction to monoclonal antibodies (mabs) to rat t cell antigens (thy 1 and pan t). they lacked surface immunoglobulins and strongly expressed rat interleuk ... | 1989 | 2788356 |
| effect of trimethoprim/sulphamethoxazole and hyperbaric oxygen on experimental spiroplasma mirum encephalitis. | this study was undertaken to determine the susceptibility of experimentally induced spiroplasma mirum infection in the rat to trimethoprim/sulfamethoxazole (tmp/smx) in combination with hyperbaric oxygen (hbo). one-day-old fisher 344 rats were intracerebrally inoculated with the gt-48 strain of s. mirum and were exposed to regimens employed combined antibiotic and hbo treatments. the exclusive use of tmp/smx produced a significant reduction in mortality (p less than 0.0001) and an absence of cli ... | 1989 | 2799063 |
| subfornical organ lesions in rats abolish hyperdipsic effects of isoproterenol and serotonin. | isoproterenol (300 micrograms/ml/kg) and serotonin (2 mg/ml/kg) given sc to rats (n = 27) caused significant drinking (fisher plsd, scheffe f test, dunnett t) in the 1 and 2 hours after injection. such drinking was completely prevented in rats later shown to have complete lesions of their subfornical organs (n = 7). in contrast a response not significantly different from the prelesion response was found in rats later given cortical lesions (n = 11) or other lesions which did not damage the subfo ... | 1989 | 2804709 |
| 1,2-dimethylhydrazine-induced carcinogenesis influenced by different colonic anastomoses in rats. | dispensing subcutaneously 1,2-dimethylhydrazine, intestinal carcinogenesis was investigated in male fisher rats with different surgical colonic anastomoses, producing blind gut loops of isoperistaltic high (fecal stasis) and anisoperistaltic low fecal contact. one hundred and eight rats, except 1 rat of the control group, developed colonic neoplasms. in contrast to the control group, mainly in anastomotic areas and in isoperistaltic blind gut loops with intensive fecal contact huge adenocarcinom ... | 1989 | 2806346 |
| characteristics of submucosal lymphoid tissue located in the proximal colon of the rat. | in this study we have examined the morphology and steroid sensitivity of proximal colonic lymphoid tissue in the fisher 344 rat. a time course study was conducted in which groups of animals were injected subcutaneously with hydrocortisone sodium succinate (125 mg/kg body weight) and killed on days 0-4. thymus, jejunal and ileal peyer's patches and proximal colonic lymphoid tissue were excised, weighed and processed for histological analysis. the results showed that the maximum cytoreductive effe ... | 1989 | 2808123 |
| heat shock-induced appearance of rna polymerase ii in karyoskeletal protein-enriched (nuclear "matrix") fractions correlates with transcriptional shutdown in drosophila melanogaster. | heat shock in vivo or brief incubation at moderately elevated temperatures (15 min at 37 degrees c) in vitro is required for the structural stability of proteinaceous karyoskeletal elements purified from drosophila melanogaster (mcconnell, m., whalen, a. m., smith, d. e., and fisher, p. a. (1987) j. cell biol. 105, 1087-1098). we have found that the appearance of the two largest subunits of rna polymerase ii in karyoskeletal preparations is promoted by conditions identical to those which promote ... | 1989 | 2492538 |
| discriminant functions. | discriminant functions (dfs), first described by fisher in 1936, have been applied to the classification of microcytic disorders such as iron deficiency and heterozygous thalassemia. mathematically dfs are weighted linear combinations of variables. if the underlying assumption of multivariate normality is valid dfs provide the best possible classification. variables may need to be transformed before the df is derived. when two groups have to be classified it is easy to visualise the df. with one ... | 1989 | 2620093 |
| [miller-fisher syndrome. presence of high signal foci in the cerebral white substance visible with magnetic resonance imaging]. | 1989 | 2610457 | |
| segregation analysis of quantitative traits in nuclear families: comparison of three program packages. | segregation analysis frequently is used to test for the presence of major gene effects and to estimate the various genetic and environmental components contributing to diseases. recent advances in both theoretical models and computational algorithms have provided a number of new programs for performing segregation analyses. we compared two newer programs: regc (part of the package "sage") and fisher/mendel with an older established program (pap) to determine relative accuracy in recovering param ... | 1989 | 2606342 |
| results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast. | a small number of patients with early stage breast cancer are found on presentation to have two or more separate carcinomas within the breast. to assess the effectiveness of conservative surgery and radiation therapy in these patients we compared treatment outcome among 10 patients with multiple lesions (21 cancers) and 707 patients with single lesions, treated at the joint center for radiation therapy between 1968-1981. median follow-up was 64 months and 75 months for the multiple and single le ... | 1989 | 2536361 |
| placenta previa and congenital cardiac anomalies. | this study was designed to evaluate the association of placenta previa (pp) with cardiac anomalies in the fetus/neonate. the study group (n = 82 babies) was compared to a control group (n = 82) matched for maternal and gestational age. five babies of the study group expired within 24 h of delivery, and postmortem examination was carried out in 4 of them. the living children of the control and study group (51 of the 77 babies) underwent complete cardiac workup including physical examination, ecg, ... | 1989 | 2486886 |
| low inspired gas temperature and respiratory complications in very low birth weight infants. | we analyzed 3705 measurements of inspired gas temperature in the first 96 hours of life, with concurrent measurements of ventilator variables and arterial oxygen tension, to determine any relationship to respiratory sequelae in 149 infants assisted by artificial ventilation. all management was with one type of ventilator (model iv100b, sechrist industries inc., anaheim, calif.) and one type of humidifier (model mr 500, fisher and paykel, auckland, new zealand), and infants were placed under radi ... | 1989 | 2921688 |
| [recurrent miller-fisher syndrome associated with brachial neuritis]. | the clinical and electrophysiological evolution of a 24-year-old patient with miller-fisher's syndrome and findings of mild peripheral neuropathy in the electromyographic study is reported. the patient had been treated six years previously for a similar disease and he recovered in 2 months. during the plasmapheresis therapy of the second episode he developed pain and weakness of the left shoulder girdle, and the emg was consistent with bilateral brachial neuritis. the disease had improved clinic ... | 1989 | 2629899 |
| fisher information as the basis for diffraction optics. | it is shown that the helmholtz wave equation follows from a new uncertainty principle: given, as data, the position of a photon in an unknown diffraction pattern, the estimated position of the centroid of the pattern will suffer minimum precision. this implies a maximally spread out diffraction pattern, obeying a principle of minimum fisher information. the minimum is constrained by knowledge of the refractive-index function n(x, y, z) of the medium through a requirement that the mean-square spa ... | 1989 | 19749868 |
| calorimetric study of fisher renormalization of tricritical behavior in mixtures of octyloxycyanobiphenyl and terephtal-bis-butylaniline. | 1989 | 9901385 | |
| [stomatological morbidity analysis in deep-sea fishermen in the gdr]. | 465 male seamen of the gdr's deep-sea fishery (about 10%) had stomatologically been examined at the open sea on board of various cargo-ships. the dmf-t index, the distribution of kinds of fillers, the proportion of primary and secondary caries, the number of teeth being missed, the distribution of eichner classes and the mode and frequency of dentures had been analysed. the quantity and quality of the stomatological care in deep-sea fishers depends on numerous factors of influence, not at least ... | 1989 | 2815159 |
| fisher syndrome. an infantile case. | a case of acute onset of partial ophthalmoplegia, ataxia and areflexia in a child is described. this case closely resembles those described by fisher (fisher syndrome). clinical data, also in relation to the few cases previously reported, are discussed. | 1989 | 2718813 |
| carotid stump syndrome: a colour-coded doppler flow study. | colour-coded doppler flow imaging (angiodynography) was performed on 29 patients with 30 internal carotid artery occlusions. large internal carotid stumps were revealed as intravascular cul-de-sacs demonstrating vortices of blue flow reversal. large carotid stumps or significant external carotid stenoses were present in nine patients (9 arteries). such patients were significantly more likely to develop symptoms of cerebral ischaemia during follow up which averaged 18 months (p = 0.016; fisher ex ... | 1989 | 2653871 |
| [treatment of fractures of the carpal scaphoid with herbert's bone screw. review of 21 clinical cases]. | twenty-one patients with scaphoid fractures treated by internal fixation with the herbert screw are reviewed. nine patients presented acute fractures and twelve had fractures with delayed or non-union. the results of these two kinds of lesions are analyzed following the criteria established by herbert and fisher in 1984. this type of internal fixation gives excellent results in isolated lesions of the scaphoid provided it is correctly executed. | 1989 | 2801079 |
| inter- and intraobserver variability in the histopathological diagnosis of medullary carcinoma of the breast, and its prognostic implications. | one hundred thirty-one breast carcinomas with medullary features, registered in the danish breast cancer cooperative group from 1977-1982, have been histopathologically reviewed by two senior pathologists and classified as typical medullary carcinoma (tmc), atypical medullary carcinoma (amc), and non-medullary carcinoma (nmc). diagnostic criteria were based on those put forward by ridolfi et al. and fisher et al. the procedure was repeated with an interval of about one year by both pathologists. ... | 1989 | 2605345 |
| [miller fisher syndrome: a report of 4 cases and review of the nosologic position]. | four typical cases of the miller fisher syndrome with external ophthalmoplegia, ataxia and generalized areflexia but no muscular weakness or sensory impairment of the limbs are reported. the nosological position of this disorder is reviewed. | 1989 | 2619616 |
| [breast saving therapy in the small breast cancer]. | according to the satisfying results reported by fisher, veronesi and other authors who used a breast-conserving operation modality in the treatment of breast cancer since 1980 109 patients with a carcinoma up to 2.5 cm underwent this kind of operation at the surgical department of the hanusch-hospital, vienna. although the median follow-up-time (29 months) is too short for conclusive statements, results of recurrence and survival compared to 162 cases of modified radical mastectomy were satisfyi ... | 1989 | 2704284 |
| correlated distribution of actin, myosin, and microtubules at the leading edge of migrating swiss 3t3 fibroblasts. | the formation of lamellipodia in migrating cells involves dynamic processes that occur in a cyclic manner as the leading edge of a cell slowly advances. we used video-enhanced contrast microscopy (vec) to monitor the motile behavior of cells to classify protrusions into the temporal stages of initial and established protrusions (fisher et al.: cell motility and the cytoskeleton 11:235-247, 1988), and to monitor the fixation of cells. multiple parameter fluorescence imaging methods (debiasio et a ... | 1989 | 2696599 |
| fisherian and wrightian theories of speciation. | fisher's theory of sexual selection, wright's shifting-balance theory, and recent models based on them are reviewed as mechanisms of animal speciation. the joint evolution of mating preferences and secondary sexual characters can cause rapid nonadaptive phenotypic divergence and premating isolation between geographically separated populations, or along a cline. extensive comparative data on drosophila species support the suggestion of r. a. fisher and t. dobzhansky that the evolution of mating p ... | 1989 | 2687093 |
| colorimetric in-situ hybridization in clinical virology: development of automated technology. | automation of in situ hybridization is an important first step toward practical implementation of the widely recognized diagnostic potential of nucleic acid hybridization. our laboratory has concentrated its efforts towards automating colorimetric in situ hybridization on formalin-fixed paraffin-embedded tissue sections. we have capitalized upon the technology developed for the automation of immunohistochemistry (brigati et al. 1988) and are collaborating with fisher scientific in modifying the ... | 1989 | 2670458 |
| [serum and cerebrospinal fluid kinetics of ceftazidime]. | ceftazidime serum concentrations and cerebrospinal fluid (csf) penetration across non-inflamed meninges were evaluated in 10 patients after intravenous application of 2 g ceftazidime over a period of 30 min. after a continuous increase during infusion the highest level of ceftazidime in serum with 172.27 micrograms/ml (+/- 60.43 micrograms/ml) was ascertained at the end of the infusion. the further development demonstrated a continuous decrease of serum concentrations. concentrations in serum fo ... | 1989 | 2693344 |