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the use of bartonella henselae-specific age dependent igg and igm in diagnostic models to discriminate diseased from non-diseased in cat scratch disease serology.cat scratch disease (csd) is caused by bartonella henselae infection and is a common cause of regional lymphadenopathy. the diagnosis of csd largely depends on serology, but is hampered by both low sensitivity and specificity of the applied igg and igm assays. using an in-house elisa, we detected a significant age-dependent increase in the igg levels in the general population compared to csd patients. with this knowledge, we developed diagnostic models to differentiate diseased from non-diseased ...200717916395
prevalence of antibodies to bartonella henselae in dogs in italy. 200717921442
a case of fatal disseminated bartonella henselae infection (cat-scratch disease) with encephalitis.cat-scratch disease resulting from bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. even the rare cases associated with neurologic manifestations are not generally fatal. we report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. to our knowledge, this finding has not b ...200717922599
bivalvular bartonella henselae prosthetic valve endocarditis.prosthetic valve endocarditis is an uncommon manifestation of infection with bartonella species. herein, we report a case of bartonella henselae endocarditis involving prosthetic mitral and aortic valves. the patient had a favorable outcome with combined medical and surgical therapy. concomitant crescentic glomerulonephritis led to an initial mistaken diagnosis of wegener's granulomatosis.200717942646
genetic diversity of bartonella henselae in human infection detected with multispacer typing.we applied multispacer typing (mst) by incorporating 9 variable intergenic spacers to bartonella henselae dna detected in lymph node biopsy specimens from 70 patients with cat-scratch disease (csd), in cardiac valve specimens from 2 patients with endocarditis, and in 3 human isolates from patients with bacillary angiomatosis, csd, and endocarditis. sixteen mst genotypes were found, 5 previously identified in cats and 11 new. of the studied dna, 78.7% belonged to 2 genotypes, which were phylogene ...200717953088
osler's nodes and janeway lesions.the pathogenesis of osler's nodes and janeway lesions remains a mystery despite vigorous debate over the last 113 years. they are given great emphasis among the clinical signs of bacterial endocarditis but are seldom seen in practice. two cases of subacute bacterial endocarditis are presented. a 66-year-old woman with bartonella henselae endocarditis developed osler's nodes on the hands postoperatively, and a 23-year-old man with streptococcus oralis endocarditis developed tender macules with an ...200717956487
[cat-scratch disease]. 200717969956
multifocal osteomyelitis due to bartonella henselae in a child without focal pain.we describe a case of an 11-year-old girl who presented with osteomyelitis of the vertebrae and right femur due to bartonella henselae. her only symptom was prolonged fever without focal pain. magnetic resonance imaging (mri) and nested polymerase chain reaction (pcr) were useful for the diagnosis. osteomyelitis due to b. henselae should be considered in cases of prolonged fever of unknown origin.200717982727
[cat scratch disease: report of a case]. 200718021527
genomic analysis of bartonella identifies type iv secretion systems as host adaptability factors.the bacterial genus bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. we determined the comp ...200718037886
characterization of th1 activation by bartonella henselae stimulation in balb/c mice: inhibitory activities of interleukin-10 for the production of interferon-gamma in spleen cells.this study was conducted to analyze cytokine production mechanisms in mice after bartonella henselae stimulation. balb/c mice were inoculated intraperitoneally with 3 x 10(6) colony forming units of b. henselae (houston-1 strain) twice at 10-day interval. spleen cells were harvested from the mice and stimulated with the organisms. following the stimulation, interferon-gamma (ifn-gamma) and interleukin-4 (il-4), il-10, il-12 and tumor necrosis factor-alpha (tnf-alpha) were measured in the culture ...200717005337
bartonella native valve endocarditis: the first brazilian case alive and well.bartonella is an important cause of blood culture-negative endocarditis in recent studies. seroprevalence studies in the states of minas gerais and rio de janeiro have shown bartonella igg positivity around 14% in healthy adults and 40% in hiv seropositive adults, respectively. a case report of a 46-year-old white male with moderate aortic regurgitation (ar) due to rheumatic heart disease (rhd), admitted due to worsening heart failure, is presented. clinical features were apyrexia, anemia, polyc ...200718327472
[a case of cat scratch disease].cat scratch disease (csd) which is usually seen in children and young adults and characterized by self limited lymphadenopathy, is caused by bartonella henselae. in this report, a 30-year-old male patient who was admitted to the outpatient clinic with the complaint of lymphadenopathy, was presented. erythrocyte sedimentation rate and c reactive protein values of the patient were normal, and anti-hiv, brucella agglutination and anti-toxoplasma igm and igg tests were negative. no bacterial growth ...200718173081
[stellar neuroretinitis and bartonella henselae infection. a case report without exposure to cats]. 200818187281
structure of the head of the bartonella adhesin bada.trimeric autotransporter adhesins (taas) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. prominent examples include yersinia yada, haemophilus hia and hsf, moraxella uspa1 and a2, and neisseria nada. taas also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. the general structure of taas follows a head-stalk-anchor architecture, where the heads are the primary mediators o ...200818688279
heterogeneity of susceptibility to fluoroquinolones in bartonella isolates from australia reveals a natural mutation in gyra.bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. our objective was to evaluate in vitro antibiotic susceptibilities of 20 new bartonella isolates from animals in australia.200818334491
detection of bartonella henselae in the blood of 2 adult horses.bartonella spp. are emerging zoonotic agents that have been found in a wide variety of domestic animals and wildlife and cause a number of clinical syndromes. bartonella sp. infection has been identified in a growing number of animal species, including cats, rodents, porpoises, and canids, but has not been reported in horses.200818346149
abscess-forming lymphadenopathy and osteomyelitis in children with bartonella henselae infection.bartonella henselae is the agent of cat-scratch disease (csd), a chronic lymphadenopathy among children and adolescents. a systemic infection is very rare and most of these cases are found in patients with immunodeficiency. here, cases involving four children of 6-12 years of age are reported. three of the children had an abscess-forming lymphadenopathy and surrounding myositis in the clavicular region of the upper arm. the diagnosis was made serologically and, in one case, using eubacterial uni ...200818349375
[a high prevalence of antibodies against bartonella and babesia microti has been found in villages and urban populations in cordoba, colombia].establishing seroprevalence against bartonella and babesia microti in arural population exposed and/or non-exposed to domestic animals in cordoba,colombia.200818368229
microbial culture of blood samples and serologic testing for bartonellosis in cats with chronic rhinosinusitis.to assess the role of bartonella spp in chronic rhinosinusitis (crs) by determining detection rates for the organism by serologic testing and microbial culture of blood samples for bartonella spp in cats with crs and control cats (cats with other nasal diseases, cats with systemic illnesses, and healthy cats).200818828717
[the diagnosis of cat-scratch-disease-associated adenitis: diagnostic value of serology and polymerase chain reaction].the diagnosis of cat scratch disease (csd) associated adenitis relies classically on the association of clinical, epidemiological and bacteriological criteria. the polymerase chain reaction (pcr) looks like a more competitive diagnostic trial than serology. we evaluated the sensitivity, specificity and predictive positive and negative values of serology in routine diagnosis of csd. a retrospective study over five years was led among patients presenting a suspicion of csd and having a serology an ...200818842353
cat scratch disease presenting as acute encephalopathy.an unusual case of primary meningo-encephalitis followed by partial complex seizure in a 9-year-old boy was found to be a symptom of cerebral bartonella henselae infection or cat scratch disease. despite one clinical relapse at 4 weeks post-presentation, he remained seizure free on carbamazepine for one year. six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with eeg abnormality. restarting carbamazepine improved his symptoms.200818843081
bartonella henselae survives after the storage period of red blood cell units: is it transmissible by transfusion?bartonella henselae is the agent of cat scratch disease and bacillary angiomatosis. blood donors can be asymptomatic carriers of b. henselae and the risk for transmission by transfusion should be considered. the objective of this study was to demonstrate that b. henselae remains viable in red blood cell (rbc) units at the end of the storage period. two rbc units were split into two portions. one portion was inoculated with b. henselae and the other was used as a control. all units were stored at ...200818937735
bartonella henselae in captive and hunter-harvested beluga (delphinapterus leucas).previously, we reported the isolation of bartonella henselae from the blood of harbor porpoises (phocoena phocoena) and loggerhead sea turtles (caretta caretta) from the north carolina coast. hematologic, pathologic, and microbiologic findings surrounding the death of a juvenile captive beluga in vancouver initiated an outbreak investigation designed to define the molecular prevalence of bartonella infection in belugas. using polymerase chain reaction analyses targeting the intergenic spacer reg ...200818957643
[ocular bartonellosis in an hiv-hvc coinfected patient].bartonella henselae is the etiologic agent of the cat scratch disease and in immunocompromised patients, of bacillary angiomatosis and peliosis hepatis. less often, ocular complications associated with b. henselae infection have been reported in immunocompetent patients and five times in hiv-infected patients. we report the case of a 42-year-old woman, coinfected by hiv-hcv, presenting with cirrhosis, who owned a cat and was hospitalized for bilateral loss of visual acuity. ophthalmologic examin ...200818706780
failure to identify an association between serologic or molecular evidence of bartonella infection and idiopathic rhinitis in dogs.to determine whether infection with or exposure to bartonella spp was associated with idiopathic rhinitis in dogs.200818710315
bartonella endocarditis mimicking adult still's disease.we describe the case of a 39-year-old caucasian woman who was admitted to the university hospital of antwerp with a clinical picture suggestive of adult still's disease. even though a transoesophageal echocardiography showed endocarditis of the aortic valve, blood cultures remained negative. additional serological testing revealed a positive result for bartonella henselae. histology of the supraclavicular lymph node showed a reactive lymph node with a positive polymerase chain reaction (pcr) for ...200818714850
cat-scratch disease of the head and neck in a pediatric population: surgical indications and outcomes.to identify the presentation of pediatric patients with head and neck manifestations of cat-scratch disease, one of the most common causes of subacute or chronic lymphadenitis in children, and to determine surgical indications and outcomes.200818722212
p26-based serodiagnosis for bartonella spp. infection in cats.bartonella henselae p26 has been identified as an immunodominant antigen expressed during feline infection. we used antisera from cats experimentally infected with b. henselae (n = 6), b. clarridgeiae (n = 4), or b. koehlerae (n = 2) and from a sample of naturally infected cats (b. henselae, n = 34; b. clarridgeiae, n = 1) to evaluate recombinant p26 (rp26) as a serodiagnostic antigen. immunoblots using antisera from cats infected with b. henselae and b. clarridgeiae reacted strongly with rp26, ...200818724780
simultaneous presence of two different copies of the 16s rrna gene in bartonella henselae.bartonella henselae is an emerging pathogen of increasing medical significance. previous investigations have revealed two different 16s rrna gene variants among b. henselae isolates, resulting in delineation of the b. henselae population into 16s rna type i and type ii isolates. while studying 191 b. henselae isolates by multi-locus sequence typing (mlst) we detected three isolates that could not be assigned to a distinct 16s rna type upon direct sequencing because of ambiguous nucleotides in a ...200818757822
[cat scratch disease: a diagnosis to be aware of!].subacute cervical lymphadenopathy among young adults may be of an infectious or malignant aetiology. we report two cases of young males with chronic cervical lymphadenopathy. a diagnosis of cat scratch disease (csd) was made by serological and molecular studies. csd is one of the most frequent infectious lymphadenopathies among young people. diagnosis of csd is dependent on clinical, epidemiological, molecular and histological criteria. the detection of antibodies to bartonella henselae and the ...200818777770
hemoplasma infection in hiv-positive patient, brazil.hemotrophic mycoplasmas infect a variety of mammals. although infection in humans is rarely reported, an association with an immunocompromised state has been suggested. we report a case of a mycoplasma haemofelis-like infection in an hiv-positive patient co-infected with bartonella henselae.200819046522
bartonella henselae antibodies after cat bite. 200819046527
cat scratch disease with encephalopathy in a 9-year-old girl. 200819067901
multiplexed whole bacterial antigen microarray, a new format for the automation of serodiagnosis: the culture-negative endocarditis paradigm.the serological diagnosis of blood culture-negative endocarditis due to coxiella burnetii, bartonella spp., brucella melitensis and legionella pneumophila is based on a manual immunofluorescence assay (ifa), which is taken to be the reference method. the automated ifa inodiag multiplexed antigenic microarray, which includes a slide with all the above bacteria and four internal controls, an incubator, a fluorescent reader and software with an algorithm of interpretation for infectious endocarditi ...200819076842
the prevalence of bartonella, hemoplasma, and rickettsia felis infections in domestic cats and in cat fleas in ontario.the prevalence of persistent bacteremic bartonella spp. and hemoplasma infections was determined in healthy pet cats in ontario. blood samples from healthy cats sent to a diagnostic laboratory for routine health assessment over the course of 1 y were tested for bartonella spp. using both polymerase chain reaction (pcr) and blood culture, and for the presence of hemoplasma by pcr. the overall prevalence of bartonella spp. by pcr and by culture combined was 4.3% (28/646) [3.7% (24/646) bartonella ...200819086373
myocarditis due to bartonella henselae. 200819088543
[prevalence igg antibodies against bartonella henselae in children with lymphadenopathy].bartonella henselae is a cat scratch disease's etiological agent which is usually manifestated as regional lymphadenopathy. in differential diagnosis of lymphadenopathy infections about etiology b. henselae are rarely taken into consideration. enlargement of lymph nodes observed in children more often than in adults are caused by bacterial, virus or parasitic factors. in this study immunoglobulines g class antibodies to b. henselae were determined among children with limphadenopathy. at 53 child ...200819209738
diversifying selection and concerted evolution of a type iv secretion system in bartonella.we have studied the evolution of a type iv secretion system (t4ss), in bartonella, which is thought to have changed function from conjugation to erythrocyte adherence following a recent horizontal gene transfer event. the system, called trw, is unique among t4sss in that genes encoding both exo- and intracellular components are located within the same duplicated fragment. this provides an opportunity to study the influence of selection on proteins involved in host-pathogen interactions. we seque ...200818065487
prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease.this study is a retrospective analysis of seven patients with hypoechogenic lesions in the liver and/or spleen due to bartonella henselae, who were followed from 1998 through to 2005 by the department of pediatrics, turin university. in addition to showing constitutional symptoms, four children had skin lesions suggestive of injuries inflicted by cats, and one child had a history of exposure to cats. the origin of the infection remained undefined in the other two patients. humoral tests enabled ...200817541640
prevalence of serum antibodies against bartonella species in the serum of cats with or without uveitis.bartonella henselae has been implicated as a causative agent of chronic uveitis in people and in some cats. the objective of this study was to determine whether bartonella species seroprevalence or titer magnitude varies among cats with uveitis, cats without ocular diseases recorded and healthy cats, while controlling for age and risk of flea exposure based on state of residence. there was no difference in seroprevalence rates or titer magnitude between cats with uveitis and cats with non-ocular ...200817719256
atypical bartonella hensalae chorioretinitis in an immunocompromised patient.to report an atypical case of chorioretinopathy in a patient with bilateral renal transplantations.200818379943
bartonella species antibodies and dna in cerebral spinal fluid of cats with central nervous system disease.bartonella species infection is associated with central nervous system (cns) disease in some humans and cats but the diagnosis is difficult to confirm with blood or serum test results. in this retrospective study of 100 client-owned cats, serum and cerebral spinal fluid (csf) were assayed for bartonella species igg antibodies and csf was assayed for bartonella species dna. bartonella species igg antibodies were detected in serum of 36 cats, bartonella species c-values>1 (suggesting antibody prod ...200818400536
emerging pathogens: challenges and successes of molecular diagnostics.more than 50 emerging and reemerging pathogens have been identified during the last 40 years. until 1992 when the institute of medicine issued a report that defined emerging infectious diseases, medicine had been complacent about such infectious diseases despite the alarm bells of infections with human immunodeficiency virus. molecular tools have proven useful in discovering and characterizing emerging viruses and bacteria such as sin nombre virus (hantaviral pulmonary syndrome), hepatitis c vir ...200818403608
visceral involvement in an immunocompetent male: a rare presentation of cat scratch disease.we report a case of an adult, immunocompetent male with lymphadenopathy of both groins, para-aortal lymph nodes and multiple lesions in the spleen. a neoplasm was excluded by histology of the largest lymph node from the left groin. the diagnosis of cat-scratch disease (csd ) became apparent when serological testing for bartonella henselae showed to be positive. a review of literature shows that disseminated (visceral) infection is a rare presentation of csd.200818424863
beyond cat scratch disease: widening spectrum of bartonella henselae infection.bartonella henselae was discovered a quarter of a century ago as the causative agent of cat scratch disease, a clinical entity described in the literature for more than half a century. as diagnostic techniques improve, our knowledge of the spectrum of clinical disease resulting from infection with bartonella is expanding. this review summarizes current knowledge regarding the microbiology, clinical manifestations, diagnostic techniques, and treatment of b. henselae infection.200818443019
[bartonella henselae and its infections].in recent years the number of identified bartonella species has increased rapidly and several species in bartonella genus isolated from various mammalian reservoirs were recognized as zoonotic agents in humans. three bartonella species are considered to be pathogenic for humans; b. henselae, b. quintana and b. bacilliformis. b. henselae causes asymptomatic intraerythrocytic bacteraemia in the feline reservoir host and is the most important zoonotic species as the cause of human diseases includin ...200818444576
seroprevalence of bartonella spp. infection in hiv patients in catalonia, spain.although the first clinical descriptions of bartonella infection were associated with immunocompromised patient with bacillary angiomatosis, we currently know that this organism is directly involved in diseases affecting a large number of patients, regardless of their immune status. cat scratch disease, hepatic peliosis, and some cases of bacteraemia and endocarditis, are directly caused by some species of the genus bartonella. the purpose of this study was to determinate the prevalence of igg a ...200818452613
severe occlusive vasculitis as a complication of cat scratch disease.the purpose of this communication is to report a severe occlusive vasculitis as a complication of cat scratch.200818454406
culture-negative infectious endocarditis caused by bartonella spp.: 2 case reports and a review of the literature.bartonella spp. are rare pathogens in humans and were recently recognized as important causative agents of culture-negative endocarditis. here, we describe the 1st 2 documented cases of culture-negative endocarditis due to bartonella henselae and bartonella quintana encountered in a single hospital in germany. infection of the heart valve tissue was detected by broad-range polymerase chain reaction (pcr) and further confirmed by serologic testing. in particular, acute b. henselae infection with ...200818455348
macular hole following bartonella henselae neuroretinitis.to report a case of macular hole secondary to bartonella henselae neuroretinitis.200818465733
[cat scratch disease]. 200818470500
molecular evidence for bartonella spp. in cat and dog fleas from germany and france.nine hundred and fifty-two fleas were collected from 148 cats and 133 dogs at 18 widely distributed geographic locations in germany and france and examined for the presence of six different bartonella spp. (bartonella bacilliformis, bartonella clarridgeiae, bartonella elizabethae, bartonella henselae, bartonella quintana, bartonella vinsonii subsp. berkhoffii) by pcr. thirty-five specimens (3.7%) tested positive for either b. henselae (14 positive fleas) or b. clarridgeiae (21 positive fleas). d ...200818489542
native valve endocarditis due to bartonella henselae in an immunocompetent man.culture-negative endocarditis accounts for 2.5-31% of all endocarditis cases and remains a diagnostic and therapeutic challenge. bartonella spp. has only recently been recognized as an important cause of culture-negative endocarditis. we report a case of bartonella henselae endocarditis occurring in an immunocompetent man who owned a cat and had previously been diagnosed with valvulopathy. diagnosis was made only after prolonged diagnostic work-up with serology and with pcr and subsequent sequen ...200818500601
use of bartonella adhesin a (bada) immunoblotting in the serodiagnosis of bartonella henselae infections.bartonella henselae causes a variety of human diseases (e.g. cat scratch disease and the vasculoproliferative disorders, bacillary angiomatosis and peliosis hepatis). the laboratory diagnosis of b. henselae infections is usually based on the detection of anti-b. henselae antibodies by an indirect immunofluorescence assay (ifa) which, unfortunately, suffers from a significant amount of cross-reactivity and hence is prone to deliver false-positive results. in this pilot study, we evaluated the use ...200818501673
rickettsial seroepidemiology among farm workers, tianjin, people's republic of china.high seroprevalence rates for anaplasma phagocytophilum (8.8%), coxiella burnetii (6.4%), bartonella henselae (9.6%), and rickettsia typhi (4.1%) in 365 farm workers near tianjin, people's republic of china, suggest that human infections with these zoonotic bacteria are frequent and largely unrecognized. demographic features of seropositive persons suggest distinct epidemiology, ecology, and risks.200818507907
[cat-scratch disease localisation in the parotid gland].cat scratch disease is an infection due to bartonella henselae. it is one of the principal causes of benign chronic adenopathy in children or young adults.200818533210
bartonella henselae: first reported isolate in a human in thailand.this is the first reported case of bacillary angiomatosis associated with bartonella henselae in thailand. the clinical, pathological, and microbiological findings are presented. the bacterium was isolated from a biopsy of skin lesions obtained on admission and identified by cellular morphology, characteristics of colonies on chocolate agar, extensive biochemical tests and 16s ribosomal dna sequencing.200818567451
detrimental effects of bartonella henselae are counteracted by l-arginine and nitric oxide in human endothelial progenitor cells.the recruitment of circulating endothelial progenitor cells (epcs) might have a beneficial effect on the clinical course of several diseases. endothelial damage and detachment of endothelial cells are known to occur in infection, tissue ischemia, and sepsis. these detrimental effects in epcs are unknown. here we elucidated whether human epcs internalize bartonella henselae constituting a circulating niche of the pathogen. b. henselae invades epcs as shown by gentamicin protection assays and tran ...200818595894
transmission of bartonella henselae by ixodes ricinus.bartonella spp. are facultative intracellular bacteria associated with several emerging diseases in humans and animals. b. henselae causes cat-scratch disease and is increasingly associated with several other syndromes, particularly ocular infections and endocarditis. cats are the main reservoir for b. henselae and the bacteria are transmitted to cats by cat fleas. however, new potential vectors are suspected of transmitting b. henselae, in particular, ixodes ricinus, the most abundant ixodid ti ...200818598628
seroprevalence of bartonella henselae antibodies in blood donors in crete. 200818609206
inguinal lymphadenopathy due to bartonella henselae.the bacterium bartonella henselae causes cat scratch disease, a self-limited zoonotic disease which is common among children and adolescents. the most typical clinical presentation is a regional lymphadenopathy that commonly involves only a single node of cervical and axillary lymph nodes. inguinal localization is rarely described. we report a case of a 35-year-old caucasian male complaining of a painless right inguinal mass and slight fever. a diagnosis of bartonella henselae infection was made ...200818622149
immune thrombocytopenic purpura as a complication of bartonella henselae infection.immune thrombocytopenic purpura is an infrequent yet well-recognized complication of viral infections, such as mumps, rubella, varicella, cytomegalovirus, parvovirus and infectious monunucleosis by epstein-barr virus. some recent studies have described a possible association between henoch-schonlein purpura, a non-thrombocytopenic purpura, and seropositivity for bartonella henselae, but in the literature only sporadic case reports have described a severe immune thrombocytopenic purpura as a comp ...200818622151
the head of bartonella adhesin a is crucial for host cell interaction of bartonella henselae.human pathogenic bartonella henselae cause cat scratch disease and vasculoproliferative disorders (e.g. bacillary angiomatosis). expression of bartonella adhesin a (bada) is crucial for bacterial autoagglutination, adhesion to host cells, binding to extracellular matrix proteins and proangiogenic reprogramming via activation of hypoxia inducible factor (hif)-1. like the prototypic yersinia adhesin a, bada belongs to the class of trimeric autotransporter adhesins and is constructed modularly cons ...200818627378
low sensitivity of bartonella henselae pcr in serum samples of patients with cat-scratch disease lymphadenitis. 200818628513
bartonella sp. bacteremia in patients with neurological and neurocognitive dysfunction.we detected infection with a bartonella species (b. henselae or b. vinsonii subsp. berkhoffii) in blood samples from six immunocompetent patients who presented with a chronic neurological or neurocognitive syndrome including seizures, ataxia, memory loss, and/or tremors. each of these patients had substantial animal contact or recent arthropod exposure as a potential risk factor for bartonella infection. additional studies should be performed to clarify the potential role of bartonella spp. as a ...200818632903
cat scratch disease complicated with aseptic meningitis and neuroretinitis.cat scratch disease (csd) is a self limited condition characterized by fever, lymph node enlargement and less often eye involvement. central nervous system involvement by bartonella henselae infection is possibly an important cause of morbidity; its role as an agent of aseptic meningitis is unknown. we report a case of a 40 years-old man with csd accompanied by aseptic meningitis and neuroretinitis. serum indirect immmunofluorescence (ifi) assays for b. henselae were positive and the cerebrospin ...200818641856
ocular bartonella infections. 200818645403
possible donor-recipient bartonellosis transmission in a pediatric liver transplant.bartonella henselae is the causative agent of cat-scratch disease and other disorders, including hepatosplenic granulomatosis. this infection has only rarely been reported after solid organ transplantation, where it can mimic the more common post-transplant lymphoproliferative disease. here we present a case of asymptomatic b. henselae hepatic and lymph nodal granulomatosis in a pediatric patient who had received orthotopic liver transplant 2 months before; we hypothesize that the causative agen ...200818651873
serological evidence for the association of bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy.arrhythmogenic right ventricular cardiomyopathy (arvc) is an important cause of sudden death in young adults. on the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death.200818666174
hepatosplenic cat-scratch fever. 200818222165
prolonged bartonella henselae bacteremia caused by reinfection in cats.we analyzed the genetic relatedness of blood culture isolates of bartonella henselae from 2 cats of patients with cat-scratch disease at admission and after 12 months. isolates from each cat at different times were clonally unrelated, which suggested reinfection by a second strain.200818258096
[ocular bartonellosis: report of three clinical cases].the characteristic clinical presentation of cat scratch disease is subacute regional lymphadenopathy; nevertheless, 5-25% of bartonella henselae infections may present an atypical or systemic form, with potential eye involvement. we describe three clinical cases of ocular bartonellosis in two adolescents and one young adult, who had close contact with cats; all of them presented persistent fever ranging from 15 to 21 days, and two of them developed a sudden unilateral loss of visual acuity assoc ...200818273527
bartonella dna in the blood and lymph nodes of golden retrievers with lymphoma and in healthy controls.although lymphoma is the most common neoplastic process reported in dogs, its precise etiology is unknown. golden retrievers are more likely to develop lymphoma, suggesting a breed predisposition; however, other factors, including environment, immunity, and infection, are likely contributors to oncogenesis.200818289294
lymphadenopathy in a novel mouse model of bartonella-induced cat scratch disease results from lymphocyte immigration and proliferation and is regulated by interferon-alpha/beta.in immunocompetent humans, cat scratch disease (csd) is elicited by the gram-negative bacterium bartonella henselae and is characterized by a benign regional lymphadenopathy, the pathogenesis of which is poorly understood. here, we describe a novel mouse model of bartonella-induced csd-like disease that allowed us to investigate the mechanisms leading to lymphadenopathy in vivo. in wild-type mice, a subcutaneous inoculation of either viable or inactivated b. henselae led to a strong swelling of ...200818292236
serological evidence of bartonella henselae infection in healthy people in catalonia, spain.cat scratch disease (csd), bacillary angiomatosis, hepatic peliosis and some cases of bacteraemia, endocarditis, and osteomyelitis are directly caused by some species of the genus bartonella. the purpose of this study was to determine the prevalence of igg antibodies against bartonella henselae in healthy people and to identify the epidemiological factors involved. serum samples from 218 patients were examined by indirect immunofluorescence assay (ifa). significance levels for univariate statist ...200818294428
feline bartonellosis and cat scratch disease.bartonella species are important emerging zoonotic pathogens. transmission of these organisms in nature may be much more complex than is currently appreciated. cats can be infected with five bartonella species, including, bartonella henselae, bartonella clarridgeae, bartonella bovis, bartonella koehlerae and bartonella quintana. in addition to cats, numerous domestic and wild animals, including bovine, canine, human, and rodent species can serve as chronically infected reservoir hosts for variou ...200818295347
hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases.the incidence of hepatic granulomas is reported in 2-15% of liver biopsies. this study was carried out to evaluate the incidence and aetiology of hepatic granulomas in a german institute of pathology with specialization in liver diseases.200818312287
isolation and characterization of bartonella bacilliformis from an expatriate ecuadorian.carrion's disease is typically biphasic with acute febrile illness characterized by bacteremia and severe hemolytic anemia (oroya fever), followed by benign, chronic cutaneous lesions (verruga peruana). the causative agent, bartonella bacilliformis, is endemic in specific regions of peru and ecuador. we describe atypical infection in an expatriate patient who presented with acute splenomegaly and anemia 3 years after visiting ecuador. initial serology and pcr of the patient's blood and serum wer ...200818094131
discovery and analysis of bartonella henselae antigens for use in clinical serologic assays.the antibody response to bartonella henselae has been studied in a number of mammals; however, the human response needs to be further studied. after natural infection, humans have antibody reactivity to a large number of b. henselae proteins. we used a proteomic approach to identify antigenic proteins of b. henselae to determine their capacity to elicit a human antibody response. comparing patient sera by western blot analysis demonstrated significant amounts of reactivity to b. henselae. the im ...200817889484
bacillary angiomatosis in a patient with chronic lymphocytic leukemia.bacillary angiomatosis is a cutaneous or visceral infection with bartonella henselae or bartonella quintana. cases usually occur in hiv infected individuals. we present a 60-year-old man with chronic lymphocytic leukemia and neutropenic fever caused by bacillary angiomatosis. the nine ba cases in oncology patients are reviewed.200818165862
bartonella henselae lymphadenitis progressing to hepatosplenic disease with slow clinical response despite early diagnosis and treatment. 200817343673
[painful soft-tissue swelling of the upper arm].cat-scratch disease is an infection by bartonella henselea and resolves spontaneously. we present a case of untypical bartonella infection which was misinterpreted by mri as a soft-tissue sarcoma of the upper arm. the histological findings of an incision biopsy were unspecific, without signs of malignancy. the tumor was excised completely and the final histology, however, showed no evidence of malignant changes. the bartonella henselae infection could be confirmed by polymerase chain reaction. t ...200817443304
evaluation of an in-house cat scratch disease igm elisa to detect bartonella henselae in a routine laboratory setting.cat scratch disease (csd) is caused by bartonella henselae infection and is a common cause of regional lymphadenopathy. the diagnosis of csd largely depends on serology, but detection of b. henselae in an affected lymph node by pcr is also an important diagnostic tool. we evaluated an igm in-house elisa protocol and analyzed its performance in routine csd serology. serum samples from pcr-positive patients (n = 126), pcr-negative patients (n = 123), and age-matched controls (n = 126) were used fo ...200918679728
bartonellosis causing bilateral leber neuroretinitis: a case report.bartonella henselae is the causal agent of cat scratch disease and one variation in its presentation is leber neuroretinitis. the unilateral presence of exudation as a macular star and papilledema represent its most common presentation.200919253255
prevalence of bartonella henselae and bartonella clarridgeiae in cats and dogs in korea.blood, saliva, and nail samples were collected from 54 dogs and 151 cats and analyzed for the presence of bartonella henselae with a novel nested polymerase chain reaction (pcr) method. bartonella (b.) henselae was detected in feral cat blood (41.8%), saliva (44.1%), and nail (42.7%) samples. b. henselae was also detected in pet cat blood (33.3%), saliva (43.5%), and nail (29.5%) samples and in pet dog blood (16.6%), saliva (18.5%), and nail (29.6%) samples. nine samples were infected with b. cl ...200919255530
[clinical thinking and decision making in practice. a man with abdominal pain, weight loss and fever]. 200919256242
identification of bartonella henselae in an aborted equine fetus.this report describes the characterization of a bartonella henselae abortion in an equine fetus by gross, histologic, immunohistochemical, ultrastructural, and molecular methods. bartonella henselae can cause cat scratch disease, bacillary angiomatosis, bacillary peliosis, and endocarditis in humans and other animals. the bacterium has been isolated from several mammalian species but only recently from equids; however, it has not been linked to abortion in equids. an aborted equine fetus exhibit ...200919261640
prevalence of bartonella henselae antibodies in children and blood donors in croatia. 200919274430
ecological fitness and strategies of adaptation of bartonella species to their hosts and vectors.bartonella spp. are facultative intracellular bacteria that cause characteristic hostrestricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. in the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. bacterial type iv secretion systems, which are supra-molecular tra ...200919284965
bacillary angiomatosis.an infection with bartonella henselae transmitted from domestic cats to humans by scratching normally leads to cat-scratch disease. when the human host has severe immunosuppression or hiv infection, the potentially life-threatening disease bacillary angiomatosis can develop. a 79-year-old man presented with livid-erythematous, angioma-like skin lesions. we considered a cutaneous infiltrate from his known chronic lymphocytic leukemia, merkel cell carcinoma, cutaneous metastases of internal tumors ...200919298547
a translocated protein of bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome.bartonella henselae enters human endothelial cells (ecs) by two alternative routes: either by endocytosis, giving rise to bartonella-containing vacuoles or by invasome-mediated internalization. only the latter process depends on the type iv secretion system virb/vird4 and involves the formation of cell surface-associated bacterial aggregates, which get engulfed by ec membranes in an f-actin-dependent manner, eventually resulting in their complete internalization. here, we report that among the v ...200919302579
[cat scratch disease with bone involvement: a case report and literature review].cat scratch disease is an infectious disease caused by bartonella henselae. most of the patients present with a lymphadenopathy associated with a local infection at the site of the cat scratch. disseminated infection is uncommon.200919303175
cat scratch disease: clinical considerations for the pediatric dentist.cat scratch disease (csd), caused by bartonella henselae, is a self-limited chronic lymphadenopathy. it is transmitted commonly by a scratch or bite from cats or kittens. diagnosis of csd is often difficult, as it masquerades as other causes of cervical lymphadenopathy or submandibular gland pathology. the purpose of this paper was to report a unique case of a 6-year old male who had close contact with a domestic dog and developed csd which progressed to suppuration. after treatment with antibio ...200919320261
proteomic analysis of the bacterial pathogen bartonella henselae and identification of immunogenic proteins for serodiagnosis.bartonella henselae is a slow growing, fastidious and facultative intracellular pathogen causing cat scratch disease and vasculoproliferative disorders. to date, knowledge about the pathogenicity of this human pathogenic bacterium is limited and, additionally, serodiagnosis still needs further improvement. here, we investigated the proteome of b. henselae using 2-d sds-page and maldi-tof-ms. we provide a comprehensive 2-d proteome reference map of the whole cell lysate of b. henselae with 431 id ...200919333998
experimental infection of cats with bartonella henselae resulted in rapid clearance associated with t helper 1 immune responses.six cats were inoculated with bartonella henselae strains a and b, which were isolated from the same naturally infected cat. the numbers of cd4(+) cells decreased following the infection. the levels of bacteremia were significantly correlated with the expression levels of ifn-gamma mrna during the various stages of bacteremia and elimination of the bacteremia. furthermore, the lower levels of tnf-alpha mrna expression during the bacteremia related to the emergence of higher levels of bacteremia. ...200919348961
molecular characterization of resistance to fluoroquinolones in bartonella henselae and bartonella quintana. 200919369272
prevalence of bartonella infection in cats and dogs in a metropolitan area, thailand.the prevalence of bartonella infection was studied in 312 cats and 350 dogs in the bangkok metropolitan areas, thailand, between june 2001 and february 2003. bartonella was isolated from 47 (16.3%) of 288 stray cats, but from none of the 24 pet cats studied. of the 47 bartonella-positive cats, 45 animals were infected with only b. henselae, one was infected with only b. clarridgeiae, and one with both b. henselae and b. clarridgeiae. 16s rrna typing showed that 40 cats were infected with b. hens ...200919379541
[positive polymerase chain reaction for bartonella henselae in conjunctival granuloma]. 200919384797
identification of a bartonella species in the harbor seal (phoca vitulina) and in seal lice (echinophtirius horridus).to explore whether harbor seals (phoca vitulina) are exposed to bartonella spp., 35 seal lice (echinophtirius horridus) were collected from seven seals, during their rehabilitation period in the seal rehabilitation and research center at pieterburen, the netherlands. forty-eight spleen samples were collected during necropsies of other harbor seals that died during rehabilitation, or had stranded dead and were brought to the seal rehabilitation and research center for postmortem investigation. li ...200919402763
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