Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| application of the soluble antigen fluorescent antibody (safa) test to the serodiagnosis of rabies. | the adaptation and evaluation of the soluble antigen fluorescent antibody (safa) test for the serologic diagnosis of rabies is described. evaluation of the safa test was based on a comparison between serum titers obtained in the safa test, the mouse serum neutralization (sn) test and in the indirect fluorescent antibody (ifat) test. dog, fox, raccoon and skunk sera were used for the comparison with mouse sn titers. human serum was used for the comparison with the ifat titer. the purity and conce ... | 1977 | 320266 |
| evaluation of tests for rabies antibody and analysis of serum responses after administration of three different types of rabies vaccines. | humoral antibody response to three types of rabies vaccines were assayed by the neutralization (nt), the mixed hemadsorption (mh), and the indirect immunofluorescence (if) tests. the nt and mh tests were used to detect antibodies combining with antigens at the surface of virions and infected cells, whereas the indirect if test measured antibodies mainly to the rabies nucleocapsid antigen. after immunization with a human diploid cell vaccine, antibodies were detected by both the nt and the mh tes ... | 1977 | 323275 |
| comparison of rabies humoral antibody titers in rabbits and humans by indirect radioimmunoassay, rapid-fluorescent-focus-inhibition technique, and indirect fluorescent-antibody assay. | rabies humoral antibodies were induced in eight new zealand rabbits by a single intramuscular injection of inactivated suckling mouse brain rabies vaccine. the primary response to immunization was measured in blood samples taken at selected intervals for 6 months. the anamnestic response was measured in blood samples obtained 2 weeks after the rabbits received a booster immunization. the humoral antibody concentrations were measured by the rapid-fluorescent-focus-inhibition technique (rffit), in ... | 1977 | 323278 |
| antibody response to rabies virus in syrian hamsters. | syrian hamsters were injected with inactivated, attenuated, and virulent rabies virus (rv), and the antibody response was quantified by a neutralization test and the immunoglobulin class of the virus antibody was characterized by indirect fluorescent microscopy. serum antibodies to rv were found to be predominantly of the immunoglobulin g2 (igg2) class, although igg1 anti-rv also were detected in high-titered sera obtained after secondary challenge. brain extracts of hamsters inoculated intracer ... | 1977 | 330398 |
| prophylaxis for exposure to rabies in humans. | 1977 | 334352 | |
| [chronic cell culture infection with the rabies virus]. | three cell cultures chronically infected with fixed rabies virus, strain mniivp-74, have been obtained: hep-2/2, bhk/13s, and rk-13. in the former two cultures, the infectious virus titers were 2.0 to 5.25 ig ld50/ml. in rk-13 cells, traces of the infectious virus were found. in the chronically infected hep-2/2 culture the maximum amount of the antigen-containing cells determined by the fluorescent antibody procedure was 60% and in bhk/13s 80%. chronically infected cultures had a reduced growth ... | 1977 | 337676 |
| administration of human interferon to rabies virus-infected monkeys after exposure. | the treatment of rabies-infected cynomolgus monkeys (macaca fascicularis) with human interferon after exposure was studied. the monkeys were infected with rabies street virus by the intramuscular route; larger than or equal to 24 hr after infection, human interferon was administered intramuscularly or by lumbar spinal injection into the cerebrospinal fluid. whereas 90% of the infected untreated monkeys died, 40%-80% of animals treated with interferon survived. no or only low levels of neutralizi ... | 1977 | 404370 |
| rabies virus glycoprotein. ii. biological and serological characterization. | purified rabies virus glycoprotein (g) was shown by complement fixation and immunodiffusion tests to be a second distinct antigen of the virus. it it the only structural protein of the virus that induces the formation of virus-neutralizing antibodies and which confers immunity to animals. when the g protein is taken as antigen, the complement fixation test can be used for the assay of virus-neutralizing antibodies. the total protective activity of the virus was recovered in the purified g protei ... | 1977 | 408269 |
| successful prophylaxis against rabies in mice and rhesus monkeys: the interferon system and vaccine. | addition of interferon to ineffective rabies virus vaccines by the local injection of either exogenous interferon or a potent interferon inducer (a complex of polyriboinosinic-polyribocytidylic acid containing poly-l-lysine and carboxymethylcellulose) into the footpads of mice previously challenged with rabies virus dramatically reduced the mortality rate. a significant reduction in mortality rate was also noted when the interferon system was administered to rhesus monkeys, but only when treatme ... | 1977 | 408427 |
| [antigenic activity of a concentrated and purified cultured antirabies vaccine from the vnukovo-32-107 strain]. | humoral response (virus-neutralizing antibody production) to immunization with inactivated 30-fold concentrated and purified tissue culture rabies vaccine was studied in monkeys and human volunteers. two doses of the preparation spaced 20 days apart and given intramuscularly or intradermally to monkeys induced in them much more intensive antibody production (4--213-fold by titer) than 6 daily injections of unconcentrated vaccine. in 10 human volunteers immunized with 1.5 ml doses of the concentr ... | 1977 | 412324 |
| enhanced cytotoxicity of human lymphocytes against rabies-infected cells by rabies-specific antibodies. | human anti-rabies immune sera enhanced the in vitro cytotoxicity of human lymphocytes against rabies virus-infected green-monkey kidney cells. the immune sera were collected from patients immunized with rabies vaccine produced either in human diploid cells or in nervous tissue. significant cytotoxicity was observed even with high serum dilutions, indicating that the k-cell assay might be a sensitive tool for detection of anti-rabies antibodies. | 1977 | 413187 |
| [evaluation of cellular immunity after rabies vaccination in man]. | the peripheral lymphocytes of vaccinated men were stimulated by homologous antigen or its subunits (nucleocapsid and glycoprotein) or by some parent viruses (mokola and lagos). all subjects produced a high level of antibody. a difference was noted between the two types of immunity. a lack of cell-mediated immunity could explain the very few failures in pasteur antirabies treatment. | 1977 | 413656 |
| [rabies]. | 1977 | 594997 | |
| [clinical and ultrastructural study of a case of human rabies]. | a patient of morracan origin, aged 26 years, who died as a result of rabies after a 15 day illness in august 1976 in bordeaux. no evidence of contamination was found by history from the patient and his family and friends nor by examination. a cerebral biopsy carried out a few hours before death confirmed the diagnosis by immunofluorescence, whilst examination under the optical microscope demonstrated negri bodies and ultrastructural studies revealed rabies virus. these findings are discussed and ... | 1977 | 601392 |
| rabies antigens in purkinje cells and granular cells separated from infected cerebellum. | 1977 | 603193 | |
| [haemagglutinin from rabies viruses (author's transl)]. | rabies virus haemagglutinin has not hitherto been obtained to our knowledge, from brain material of infected animals. a slight modification of the arbovirus technique and the use of trypsin treatment can reveal a good haemagglutinin from fixed and street strain from infected brains. | 1977 | 610505 |
| neurological symptoms in a cat following vaccination with high egg passage flury rabies vaccine of chicken embryo origin. | the development of neurological symptoms in a cat following vaccination with the high egg passage flury rabies vaccine and the subsequent isolation of a virus with characteristics consistent with the criteria for distinguishing the high egg passage flury strain of rabies virus are described. | 1977 | 614535 |
| [isolation of the lagos-bat virus in the central african republic]. | the second reported isolate of lagos-bat virus has been obtained from bats micropterus pusillus caught in 1974 in the central african empire, thus extending the geographic area of this virus and adding another species of vertebrate host among its reservoirs. | 1977 | 615673 |
| [evaluation of pre- and post-exposure schedules of rabies vaccines produced on tissue cultures]. | 1977 | 617854 | |
| induction and biological properties of defective interfering particles of rabies virus. | a method for obtaining large quantities of defective interfering (di) rabies virus particles that fulfill all the criteria delineated by huang and baltimore (1970) is described. the purified rabies di virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of about half the size of normal rabies rna but with all of the structural proteins of standard virions. rabies di virions were noninfectious for both cells in culture and for animals. as ... | 1977 | 833940 |
| interfering and noninterfering defective particles generated by a rabies small plaque variant virus. | 1977 | 835245 | |
| rabies virus and antibody in bats in grenada and trinidad. | rabies virus was detected by fluorescent-antibody and mouse inoculation tests in the brain of one bat, artibeus jamaicensis, collected at la tante, grenada on 19 june 1974. no rabies virus was found in the brains and/or salivary glands of 411 other grenadian bats of 6 species tested, including 56 a. jamaicensis. rabies neutralizing antibody was detected by the rapid fluorescent focus inhibition test (rffit) in 27 of 353 grenadian bats. positives occurred in each of the 6 species sampled, with 40 ... | 1977 | 864845 |
| [immunogenicity, efficacy and reactogenicity of a human diploid cell strain (hdcs) rabies vaccine in man; recommendations for pre- and post-exposure application (vaccination scheme) (author's transl)]. | since 1973 a total of 365 individuals between 4 and 74 years of age were vaccinated with the hdcs-rabies-vaccine produced by mérieux/lyon. only minor local side reactions were observed in some patients. no adverse systemic reactions due to the vaccine occurred in any of the vaccinees. seroconversion was observed in 100% of the vaccinated subjects. neutralizing antibodies could be demonstrated in all 365 vaccinees in titers ranging from 1:10 to 1:2238 (0.35 to 72.5 i.u) employing 200 ld 50 of rab ... | 1977 | 865381 |
| rabies in the arab republic of egypt: iii. enzootic rabies in wildlife. | five hundred and thirty-two rodents (10 species) and 112 other wild mammals (six species) were examined for rabies infections in egypt. rabies virus was isolated from the brains of three (1-2%) of 249 gerbils, gerbillus gerbillus and one (1-8%) of 56 foxes, vulpes species. in neutralization tests these isolates were found to be identical to classical rabies virus. significant numbers of rodent and other wild mammal species need to be examined before they may be excluded as possible reservoirs of ... | 1977 | 875104 |
| a mouse model for post-exposure rabies prophylaxis: the comparative efficacy of two vaccines and of antiserum administration. | 1977 | 886303 | |
| oligosaccharides of the glycoprotein of rabies virus. | the number of oligosaccharide side chains on rabies virus glycoprotein (g-protein) was investigated. analysis of glycopeptides obtained by protease digestion of desialated g-protein revealed three discrete glycopeptides. comparison of the protease digestion products from desialated and from untreated g-protein indicated a heterogeneity among the glycopeptides in the sialic acid content. two major tryptic glycopeptides were isolated from desialated rabies virus g-protein and analyzed after protea ... | 1977 | 886651 |
| results of chromosome analysis of rabies virus infected human diploid cells (wi-38). | fixed rabies virus strains did not induce mitotic or chromosome abnormalities in infected wi-38 cultures. infected cells were shown to undergo mitosis thus indicating an endosymbiotic type of infection. | 1977 | 889448 |
| differences in efficiency of protective effect caused by high ambient temperature in mice infected with diverse substrains of rabies virus. | we have shown previously that a non-fatal outcome of infection with street rabies virus occurs more often when mice are exposed to a high ambient temperature (hat = 35 degrees c) early in the course of the infection. to determine what influence the virus strain had on this protective effect of hat, we have extended these observations to studies of a fixed rabies strain, cvs and several substrains of cvs virus derived from temperature-sensitive (ts) mutants. in all cases, mortality was reduced to ... | 1977 | 894265 |
| chronic recrudescent rabies in a cat. | 1977 | 896802 | |
| [chronic rabies infection in mice intracerebrally infected with street virus]. | experimental white mice inoculated intracerebrally with street virus developed the clinical form of chronic rabies infection. the duration of clinical manifestations in the animals with the chronic course of the disease was 55 days. in all the cases the disease was fatal. virological, immunofluorescent and electron microscopic examinations of the brains of these mice have shown that in the chronic form of rabies, in contrast to the acute form, (a) the infectious virus titre is by 4-5 orders lowe ... | 1977 | 898889 |
| [a contribution on the problem of silent infection of the human organism with rabies virus]. | 1977 | 899081 | |
| characteristics of 11 rabies virus isolates in mice: titers and relative invasiveness of virus, incubation period of infection, and survival of mice with sequelae. | mice were inoculated intracerebrally or in the footpad with 11 salivary gland suspensions from rabid foxes, skunks, and bobcats. the 11 isolates differed in their ratios of intracerebral titer to footpad titer, a result indicating that the "invasiveness" of different isolates varies markedly. the degree of invasiveness could not be correlated with the species of animal. the inoculation of the less invasive isolates resulted in an appreciable number of permanently paralyzed animals (survivors wit ... | 1977 | 903672 |
| [effect of trypsin and rnase on the morphology and biological properties of the rabies virus]. | 1977 | 906282 | |
| [immunogenic activity of cultural antirabies vaccine inactivated by gamma-rays]. | experimental lyophilized tissue culture rabies vaccine inactivated with gamma-rays was prepared from the vnukovo-32 strain and showed a sufficiently high immunogenic activity. complete inactivation of the virus and the immunogenic potency of the vaccine depended upon the dose of irradiation and temperature during irradiation. the virus lost infectivity at 18 degrees c when irradiated with 2.6 x 10(6) r and at --70 degrees c with 4.55 x 10(6) r. however, the immunogenic potency of the vaccine ina ... | 1977 | 906444 |
| rabies pathogenesis. | 1977 | 907476 | |
| role of host immune response in the development of either encephalitic or paralytic disease after experimental rabies infection in mice. | the clinical and histopathological manifestations of the infection of immunosuppressed (cyclophosphamide-treated) and immunocompetent (control) adult mice with the cvs ts 2 strain of fixed rabies virus were correlated with the kinetics of virus multiplication in the central nervous system and with the development of serum antibody. in immunocompetent mice severe paralytic disease causing 80% mortality was accompanied by marked inflammation and degeneration of the central nervous system parenchym ... | 1977 | 908617 |
| rna syntheses in bhk21 cells infected by rabies virus. | in bhk21 cells infected by rabies virus, viral rna syntheses are detectable from the first 4 hours till at least 20h after the adsorption period. cellular rna syntheses are not inhibited by the virus. the viral rna syntheses are 10 times lower than syntheses induced in infected cells by vsv. they are also slower since the maximum is between 8 and 12h after infection. at least 3 categories of molecules are synthesized: 1) short (+) molecules sedimenting between 8 and 25 s, and possibly at 30 s; 2 ... | 1977 | 911111 |
| [rapid detection of rabies antibodies by immunoenzymatic assay]. | the antigen is a semipurified tissue culture virus, and peroxidase conjugated anti-human immunoglobulines are used. when sera from immunized humans are evaluated by this procedure, the values obtained show a good correlation with seroneutralization titres. the detection of antibodies by this method is earlier than by seroneutralization. | 1977 | 911112 |
| comparison of the lipid composition of rabies virus propagated in nil 2 cells maintained in monolayer versus spinner culture. | 1977 | 911869 | |
| the counterimmunoelectrophoresis test for detection of antibodies to rabies virus. | the screening for antibodies to rabies virus has been the subject of interst in ecologic studies and serologic surveys of this zoonosis. the methods most commonly used for these purpose have included the serum neutralization (sn) and indirect fluorescent antibody test [23, 22 6, 15]. the maintenance of laboratory animals or the requirement for special reagents are among the generally recognized limitations of these techniques. furthermore, in the case of the sn test, a period of fifteen days is ... | 1977 | 921140 |
| [detection of rabies virus in rodents and insectivora--a contribution to the epidemiology of rabies]. | 1977 | 921718 | |
| non-specific resistance against rabies virus in mice, rats & guineapigs. | 1977 | 924528 | |
| [effect of age of laboratory animals on the replication of fix and street rabies virus in the cns]. | 1977 | 928786 | |
| praomys (mastomys) natalensis: an african mouse capable of sustaining persistent asymptomatic rabies infection. | 1977 | 931261 | |
| in vitro evidence of cell-mediated immunity after exposure of mice to both live and inactivated rabies virus. | mice exposed to live or beta-propiolactone-inactivated rabies virus generated a strong, specific cell-mediated cytotoxic response which was generally maximal 6 days after inoculation. release of 51cr was apparently a function of immune thymus-derived lymphocytes (t cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns. cytotoxicity was always maximal for interactions ... | 1977 | 299948 |
| suppression of cell-mediated immunity by street rabies virus. | mice lethally infected with street rabies virus failed to develop cytotoxic t cells specific for rabies virus-infected target cells, whereas high levels of cell-mediated cytotoxicity (cmc) were generated after nonfatal infection with the attenuated high egg passage (hep) or era rabies virus strains. furthermore concurrent infection with street, but not with hep, rabies virus suppresses development of a primary (but not a secondary) cmc response specific for influenza virus. no cross-reactivity i ... | 1977 | 301176 |
| airborne rabies encephalitis: demonstration of rabies virus in the human central nervous system. | a veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. epidemiologic study determined a respiratory mode of transmission. after a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. identification, isolation, experimental disease production, and tissue cytopathic effects of virus recovered from the brain fulfilled koch's postulates in this unusual instance of virus disease of the ... | 1977 | 556820 |
| lipids of rabies virus and bhk-21 cell membranes. | the lipid composition of highly purified flury strain of rabies virus (hep) propagated in bhk-21 cells in a chemically defined medium was observed to be 6.7% neutral lipids, 15.8% phospholipids, and 1.5% glycolipids. in the virion, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelin were the most abundant phospholipids, accounting for 90% of the total, and the molar ratio of cholesterol to phospholipid was 0.48. uninfected bhk-21 cell membranes were obtained by nitrogen cavitation t ... | 1977 | 557573 |
| rabies virus protein synthesis in infected bhk-21 cells. | rabies virus specific polypeptide synthesis was examined under hypertonic conditions, which selectively inhibit cellular protein synthesis. the rabies virus proteins (l, g, n, m1, m2) were synthesized throughout the course of infection, with little change in their relative rates of synthesis. the rates of synthesis of the g and m1 polypeptides were more sensitive to increasing osmolarity than those of the l, n, and m2 polypeptides. extrapolation to isotonicity of the results obtained under hyper ... | 1977 | 558341 |
| virion rna polymerases of two salmonid rhabdoviruses. | rna-dependent rna polymerases were found to be associated with two salmonid rhabdoviruses: infectious hematopoietic necrosis (ihn) virus and the virus of hemorrhagic septicemia (vhs). the protein composition of these rhabdoviruses closely resembles that of rabies virus rather than that of vesicular stomatitis virus (mcallister and wagner, 1975). the optimal temperature for in vitro transcription was found to be approximately 18 degrees c for ihn virus and approximately 15 degrees for vhs,, close ... | 1977 | 559780 |
| interaction of non-specific inhibitor and rabies virus haemagglutinim. | in order to elucidate the properties of an inhibitor of rabies virus haemagglutinin in normal animal sera, experiments were made with the hep flury strain and calf serum which contains the inhibitor. the results of physico-chemical treatment, gel-filtration and density analysis suggested lipoprotein involvement. when inhibitor and haemagglutinin were mixed, the separate activities could be recovered from the mixture by centrifuging on a sucrose density gradient. by contrast, neither haemagglutin ... | 1977 | 560427 |
| a comparison of the pasteur and pitman-moore strains of rabies virus for the production of rabies vaccine in human diploid cells. | 1977 | 561073 | |
| [zonal centrifuge purification of human rabies vaccine obtained on bovine foetal kidney cells (author's transl)]. | a human rabies vaccine is prepared on bovine foetal kidney cells in absence of serum. this vaccine is concentrated and purified by zonal centrifugation. an immunogenic vaccine is obtained from the purified viral particles. preliminary results are reported. | 1977 | 563208 |
| purified duck embryo rabies vaccine. an accelerated schedule for preexposure immunization against rabies. | seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (dev) or duck embryo rabies vaccine purified by ultracentrifugation (p-dev). mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. there were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. however, local and sys ... | 1977 | 577520 |
| naturally occurring rabies virus and neutralizing antibody in two species of insectivorous bats of new york state. | seven colonies of eptesicus fuscus , the big brown bat, and five colonies of myotis lucifugus , the little brown bat, in new york state were sampled for rabies virus and virus-neutralizing antibody. eight of 278 e. fuscus were found to have virus, while 18 of 187 had antibody titers of ≥1:8. one of 333 m. lucifugus yielded virus, while three of 127 had antibody. these data demonstrate the presence of rabies virus as well as immunity to rabies in some insectivorous bats of new york state. evaluat ... | 1977 | 24228955 |
| [efficacy of disinfectants against rabies virus (author's transl)]. | a variety of disinfectants was tested against, their efficacy against rabies virus flury lep strain. the efficacy was tested by intracerebral inoculation of a mixture of virus and disinfectant into 11-15 g white mice after evaluation of the intracerebral toxic dose. two disinfectants, based on phenolecompound, showed a marked superior effect compared with other disinfectants. one disinfectant based on quarternary ammoniumbase showed insufficient efficacy. | 1978 | 581630 |
| [newly developed virusvaccines in veterinary medicine (author's transl)]. | newly developed vaccines in veterinary medicine can be classified into two categories. the first category comprises inactivated vaccines produced by "classical" methods such as inactivation of the virus by formalin and the use of a1(oh)3 as adjuvant. besides, this category also includes live vaccines from attenuated virus. thus, all of these vaccines represent no genuinely new developments and owe their origin to the fact that the importance of several virus diseases of animals has grown in the ... | 1978 | 566007 |
| rabies post-exposure treatment and side-effects in man using hdc (mrc 5) vaccine. | 126 patients underwent a post-exposure antirabies treatment using the beta-propiolactone inactivated (hdc) mrc-5 vaccine. the immunization schedule consisted of single doses of 1 ml of vaccine administered on days 0, 3, 7, 14, 30 and 90. within the post-exposure group several patients suffered wounds from known rabid animals. serum samples were collected on days 0, 14, 30, 90 and 104. neutralizing antibodies against the rabies virus were determined in the rapid-fluorescent-focus-inhibition (rffi ... | 1978 | 567152 |
| selected isolates of bovine viral diarrhea (bvd) virus propagated on bovine turbinate cells: virus titer and soluble antigen production as factors in immunogenicity of killed bvd virus. | soluble antigen production in a bovine turbinate cell line by 17 isolates of bovine viral diarrhea virus was studied. we showed that the quantity of soluble antigen produced may vary considerably between isolates. further, the isolate producing the greatest quantity of soluble antigen produced a higher antibody titer in calves than an isolate producing only half as much soluble antigen. | 1978 | 568462 |
| [ecological and epidemiological problems of the natural type of rabies]. | 1978 | 371286 | |
| [physical and antigenic structure of the rabies virus]. | 1978 | 306055 | |
| [a purified rabies vaccine from human diploid cell cultures (author's transl)]. | in order to improve the tolerance of rabies vaccine from human diploid cell cultures, the rabies virus antigen is purified in the sucrose density gradient by means of a flow ultracentrifuge. the purified virus has a specific infectiosity of 10(9) ld50 and a speicific activity of 250 units "relative activity" per 1 mg protein. the purified vaccine has been shown to be well tolerated, effective and stable. | 1978 | 306057 |
| the role of antibody in recovery from experimental rabies. i. effect of depletion of b and t cells. | the avirulent high egg passage (hep) strain of rabies virus produces an inapparent infection limited to the central nervous system (cns) in intracerebrally inoculated adult mice. heavy chain isotype (anti-mu antiserum) immunosuppression potentiates the infection, with a mortality of about 60% and with elevated virus titers in the brain. anti-mu-treated mice fail to raise antibody responses to rabies virus although their t cell function is normal when measured by the concanavalin a response of sp ... | 1978 | 307577 |
| [prevention and treatment of rabies in human beings (author's transl)]. | 1978 | 619349 | |
| rabies viruses increase in virulence when propagated in neuroblastoma cell culture. | several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. the virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems. | 1978 | 628831 |
| [rabies in a veterinarian]. | a 57-year-old veterinary surgeon developed rabies 174 days after injury during an oral palpation of a rabid cow. he had been vaccinated prophylactically with duck embryo vaccine several months before exposure but never had his serum antibody level controlled. he died 45 days later. the prodromal and encephalitic stage lasted 5 days each. intensive supportive medical treatment was given from the beginning of the paralytic stage. the clinical course was complicated by progredient respiratory failu ... | 1978 | 644276 |
| [latency and vertical transmission of rabies virus in naturally infected muridae]. | 1978 | 654711 | |
| rabies vaccine virus infection in three dogs. | ascending paralysis developed in 3 dogs, 12 to 14 days following inoculation with a modified live virus, chicken embryo origin, low egg passage, flury strain rabies vaccine. the paralysis began in the inoculated limb but rapidly involved both hindlimbs. partial paresis of the forelimbs was seen several days following the hindlimb paralysis in all 3 dogs, and in 1 of these dogs the infection ascended rapidly to the brain as well. two of the dogs recovered within 1 and 2 months, respectively, but ... | 1978 | 659318 |
| immunization with a human diploid cell strain of rabies virus vaccine: two-year results. | antibody responses following primary vaccination with 1.0 ml of intramuscularly (im) or 0.1 ml of intradermally (id) administered human diploid cell rabies virus vaccine were observered for two years. three primary doses of vaccine were given to 77 volunteers on days 0, 28, and 56. an antibody response was detected in all vacinees after a single dose; at one month, the response in the group that received vaccine id was identical to that in the group that was given vaccine im, although only 1/10t ... | 1978 | 659922 |
| isolation of rabies virus from bats in bolivia. | rabies virus was isolated from apparently normal blood-sucking (desmodus rotundus) and insectivorous (artibeus planirostris) bats caught in bolivia. the virus was identified by immunofluorescence, biological and sero-neutralisation tests. | 1978 | 664008 |
| [attempts to infect rhipicephalus sanguineus (latr.) ticks with the rabies virus]. | 1978 | 672778 | |
| the landscape epidemiology of rabies in virginia. | rabies virus, the gray fox, and the alleghenian biotic region form a pathobiocenose; rabies in virginia exists in a diffuse nidus, the alleghenian biotic region. physiographic features may serve as barriers or as passageways for epidemic spread of rabies. epidemic spread is characterized by a radial pattern and a linear northeast-southwest pattern reflecting physiographic features. incidence of rabies in the fox varies according to seasons. present control efforts are generally ineffective; unde ... | 1978 | 677370 |
| human rabies immunoprophylaxis using hdc (mrc-5) vaccine. | in a field trial 181 high risk persons of both sexes between ages of 2--71 years were prophylactically vaccinated against rabies with the beta-propiolactone inactivated rabies-vaccine (hdc) mrc-5. 1 ml of vaccine was administered intramuscularly on days 0, 7 and 21. serum samples were collected on days 0, 7, 21 and 35. neutralizing antibody titers against the rabies virus were determined in the rapid fluorescent focus inhibition test, 7 days after the first injection measurable titers of antibo ... | 1978 | 680382 |
| serovaccination by human immune globulin and hdcs-vaccine against rabies. | a serological study was performed in 16 volunteer subjects and 3 patients to determine the active antibody response after vaccination with hdcs vaccine alone and in conjunction with rabies immunglobulin of human origin (righ). when heterologous antiserum from horse or mule and any rabies vaccine is used for passive-active immunization, a pronounced interfering effect is observed, depending upon the relative concentrations of preformed rabies antibodies given and rabies virus antigen of the vacci ... | 1978 | 680386 |
| standardization of methods used for testing the safety of tissue culture rabies vaccines. | tissue culture rabies vaccines are essentially new preparations intended for prophylaxis and treatment of rabies. however, the methods used for their testing are mostly the same as those used for rabies vaccines prepared from brain tissue. therefore, it is extremely important to develop and standardize methods for testing tissue culture rabies vaccines. the main criteria for the evaluation of vnukovo-32 production strain have been formulated. the strain has been characterized in pathomorphologic ... | 1978 | 680394 |
| a purified human diploid cell rabies vaccine. | continuous-flow isopycnic banding of rabies virus in sucrose gradient was used to purify the antigen for the preparation of a human diploid cell rabies vaccine. prior to the addition of the stabilizer, the average specific potency of several vaccine batches was 234 antigenic values per 1.0 mg of protein. further data regarding potency and stability of this vaccine are presented. | 1978 | 680396 |
| cell-mediated immunity and postexposure protection from rabies by inactivated vaccines of tissue culture origin. | a strong cell-mediated cytotoxic response (cmc), which was maximal 6-7 days after treatment, was generated in mice exposed to inactivated rabies virus vaccine. cmc response was linear and was a function of antigenic mass. live attenuated viruses also generated a strong cmc response after intracerebral infection. mice lethally infected with virulent strains of virus failed to develop cmc. there was, however, no difference in the rate and amount of virus-neutralizing or lytic antibodies and interf ... | 1978 | 680397 |
| development and clinical trials of the new human rabies vaccine of tissue culture (human diploid cell) origin. | a new type of rabies vaccine for human prophylaxis was developed by workers at the wistar institute, philadelphia, pa. vaccine is prepared from rabies virus infected tissue cultures of human diploid cells and is inactivated following concentration and purification of virus. vaccine is being successfully used for prophylactic and postexposure treatment in humans with reduced number of doses and is virtually free from adverse reactions associated with the use of other types of rabies vaccines. | 1978 | 680399 |
| structure and function of rabies virus glycoprotein. | of the three major proteins associated with the rabies virus membrane, only the glycoprotein (g-protein) was found to be located on the external surface of the viral membrane. a minor glycoprotein (gp 50) detected by sds-polyacrylamide gel electrophoresis (page) of rabies virus appeared to be a breakdown product of the g-protein. glycoprotein prepared by treatment of rabies virus with triton x100 and purified by isoelectric focusing was found to be homogeneous with respect to size and isoelectri ... | 1978 | 680401 |
| evaluation of the inactivated tissue culture rabies vaccine from the vnukovo-32 strain. results of its industrial production and field use for post-exposure immunization of man. | during 1973-1977, 981,000 doses of rabies vaccine were prepared in primary young syrian hamster kidney cell cultures infected with attenuated rabies virus (strain vnukovo-32) and inactivated by uv-irradiation. potency of the vaccine varied from 0.3 to 3.5. more the 53% of vaccine lots had potency in the range of 1.1-3.5 (nih). post-exposure immunization was carried out in 45,842 persons aged from 2 weeks to greater than 76 years. the vaccination course lasted from 2 to 25 days and was followed b ... | 1978 | 680402 |
| delayed type hypersensitivity in mice immunized with inactivated rabies virus. | evidence of the dth reaction is in agreement with in vitro observation done with the lymphoblast transformation test in rabbits (5,8) or with the cytotoxicity test in mice (7). the footpad test (fpt) fulfilled all criteria of dth. a maximum swelling at the injection site was observed 24 h after challenge. fpt could not be transferred by immune serum. but both local and systemic transfer of dissociated spleen cells or lymph node cells sensitized recipient mice to the fpt. a lymphoproliferative re ... | 1978 | 680403 |
| [rabies virus study by the plaque forming system. a simplified technique]. | the author describes here a simplified and economical plaque forming system for rabies virus study. it is achieved in three steps (cells preparation and infection, apply of overlay, staining). it presents more advantages than previous techniques: time as well as culture media and handling spearing, easy and durable reading. cells prepared with di-ethyl-amino-ethyl-dextran are added to equal quantities of diluted virus (for titration) or to virus-serum mixing (for seroneutralization) and overlaid ... | 1978 | 686516 |
| role of bandicoots in rabies transmission. | 1978 | 689710 | |
| immunoglobulin (igg) and (igm) antibody responses to rabies vaccine. | igm and igg neutralizing antibody responses were estimated in the sera of rabbits and mice immunized with different doses of semple, duck embryo and cell culture rabies vaccines. igm synthesis was prolonged in animals immunized with multiple doses of either semple or duck embryo vaccines but not those immunized with cell culture vaccine. mice were passively protected by igg antibody against subsequent challenge but not by igm of equivalent neutralizing titre. mice challenged when the antibody re ... | 1978 | 690611 |
| inhibition of rabies virus in vitro by the ammonium-5-tungsto-2-antimoniate. | in vitro multiplication of rabies virus was inhibited by a condensed mineral ion, ammonium-5-tungsto-2-antimoniate (hpa 23). the inhibitory effect was evaluated by two different methods, plaque reduction and one step virus growth. plaquing showed 50% inhibition with 4.5 microgram/ml of hpa 23 and complete inhibition with 12.5 microgram/ml. a reduction of two logs in virus yield was obtained in bhk21c13s cells in suspension treated with 50 microgram/ml of hpa 23. inhibition also occurred when tre ... | 1978 | 690613 |
| [effect of temperature on the biological properties of the rabies virus]. | 1978 | 695300 | |
| [adaptation ability of 2 rabies-virus strains, isolated in central europe, to i domesticated and 2 wild animal species. contribution to the epidemiology of rabies. 1. transmission studies on weasels]. | 1978 | 696081 | |
| [serologic studies of neutralizing antibodies against rabies virus occuring in wild central european species]. | 1978 | 697718 | |
| an electron microscopic study of the surface structures and hemadsorption on chick embryo cells infected with rabies virus. | characteristic alterations at the surface of chick embryo cells infected with the hf-tc strain of rabies virus and the binding sites of hemadsorption were studied employing both scanning and transmission electron microscopes. the initial alteration of the cell surface structure revealed by scanning electron microscopy was an appearance of elongated and reticulated microvilli on the 2nd day after virus inoculation. on the 3rd day, numerous bullet-shaped virions could be seen budding as single, te ... | 1978 | 708267 |
| studies on beta-propiolactone inactivated suckling mouse brain antirabies vaccine. | 1978 | 721195 | |
| immunization against rabies with rabies immune globulin, human (righ) and a human diploid cell strain (hdcs) rabies vaccine. | 1978 | 721838 | |
| transcriptional mapping of rabies virus in vivo. | synthesis of the proteins of rabies virus was studied in hamster cells infected with uv-irradiated virus. the uv target size of genes l, n, m1, and m2 was measured during primary transcription. except for n, the target size of the remaining genes was considerably larger than that of their physical sizes. the data fit the hypothesis that four genes occupy a single transcriptional unit and that transcription of rabies virus proceeds in the order n, m1, m2, and l. | 1978 | 722860 |
| growth of low egg passage (flury) rabies virus in vero cells - preliminary report. | 1978 | 728635 | |
| [pathomorphological changes in the central nervous system as a criterion of attenuation of rabies virus strain following tissue culture passage]. | 1978 | 733014 | |
| [preparatory extraction and study of the structural proteins of rabies virus]. | a technology for preparation of purified concentrates of rabies virus has been developed permitting to use simultaneously dozens of liters of tissue culture virus-containing fluid for the preparation of a concentrate. when concentrated 10(4)-fold or more, the degree of virus purification relative soluble proteins was at least 8 x 10(6). the virus yield in purified preparations was approximately 500 microgram of protein per 10 1 of the original culture fluid. purification and preparation of a sur ... | 1978 | 735018 |
| comparative study on antibody determination by different methods in sera of persons vaccinated with hdcs-vaccine. | the comparative studies undertaken by 7 laboratories in 6 countries show that the calculation i.u.s did not as anticipated minimize but actually enhanced the variability of results of rabies antibody estaminations in the sera of hdcs vaccines. the high biological variance in the method(s) may not have been considered by individual laboratories and any neglect of fundamental biostatistical laws, unfortunately, diminishes the theoretical advantage of using the "international standard (i.s.)" as a ... | 1978 | 735548 |
| rabies antibody prevalence and virus tissue tropism in wild carnivores in virginia. | carnivores trapped in a rabies control program in virginia were examined for rabies virus and serum neutralizing antibody. local antibody prevalence ranged from 0% to 29% in gray foxes (urocyon cinereoargenteus). rabies virus was pantropic in naturally infected gray foxes and a bobcat (lynx rufus). | 1978 | 739588 |
| [immunoprophylaxis of rabies (author's transl)]. | in the past hempt-rabies vaccine produced in the gdr proved to be effective and relatively innocent like other brain-tissue-vaccines. connected with progress in virology and genetics the production of rabies-vaccines changed to cell culturing techniques. the rabies viruses got adapted to embryonated eggs of chicken and duck, and it multiplies now in tissue-cultures like hamster kidney cells, chicken fibroblasts and human diploid cells too. it is possible now to produce a cell culture vaccine of ... | 1978 | 742243 |
| [adaptability of two rabies strains isolated in central europe from 1 domesticated and 2 wild species. a contribution on the epidemiology of rabies. 2. transmission studies in wild hamsters with a fox isolate]. | 1978 | 742259 | |
| [adaptability of two rabies strains isolated in central europe from one domesticated and two wild species. a contribution on epidemiology of rabies. 3. transmission studies in field hamsters with a rodent isolate]. | 1978 | 742260 |