Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| postpartum lupus erythematosus associated with parvovirus b19 infection. | we describe postpartum onset of systemic lupus erythematosus (sle) associated with parvovirus b19 infection in a mother presenting with fever, polyarthritis, erythema, and multiorgan involvement. b19 infection was revealed by detection of b19 dna and igm antibodies. in addition, our patient showed low cd4+ (384 x 10(6)/l) and cd8+ (213 x 10(6)/l) t cells, high immunoglobulin values (23.77 g/l), hypocomplementemia, thrombocytopenia, leukopenia, and anemia. her daughter had rash associated with in ... | 1997 | 9150091 |
| experimental infection of cynomolgus monkeys with simian parvovirus. | simian parvovirus is a recently discovered parvovirus that was first isolated from cynomolgus monkeys. it is similar to human b19 parvovirus in terms of virus genome, tropism for erythroid cells, and characteristic pathology in natural infections. cynomolgus monkeys were infected with simian parvovirus to investigate their potential usefulness as an animal model of human b19 parvovirus. six adult female cynomolgus monkeys were inoculated with purified simian parvovirus by the intravenous or intr ... | 1997 | 9151844 |
| parvovirus b19-antibody serosurvey in 500 developmentally disabled subjects. | sera of 500 residents were screened for parvovirus b19 immunoglobulin m (igm) and immunoglobulin g (igg) by enzyme-linked immunosorbent assay. positive igm and equivocal igg or igm results were confirmed by immunofluorescent antibody and western blot. igm was detected in 13 sera (2.6%), and igg was detected in 285 (57%). records of igm-positive residents contained no evidence of erythema infectiosum or polyarthropathy. | 1997 | 9154477 |
| [human parvovirus b19 infection in a child suffering from chronic arthritis]. | the pathogenicity of the human parvovirus b19 has been disclosed in the last two decades. different syndromes (erythema infectiosum or hydrops fetalis) can be produced by this virus as well as aplastic crisis in patients with haemolytic anaemia. it is a common infection both in adults and in children. the frequency of joint symptoms in erythema infectiosum is about 8% in childhood but tenfold of it in the adults. however, the arthropathy could be the only symptom without constitutional complains ... | 1997 | 9157338 |
| quantitation of parvovirus b19 dna sequences by competitive pcr: differential hybridization of the amplicons and immunoenzymatic detection on microplate. | a competitive pcr assay was developed to quantify b19 dna sequences. target and internal standard sequences were co-amplified by the same set of primers. the internal standard competitor was constructed by recombinant pcr and differed from the original genome sequence in a 21-bp mutagenized fragment, internal to the region amplified by the same set of primers. the internal standard competitor was cloned in a plasmid vector and the cloned fragment used in all the experiments. target and internal ... | 1997 | 9160327 |
| [parvovirus b19 in the czech republic. seroepidemiologic study]. | erythema infectiosum which is caused by parvovirus b 19 is notified in the czech republic similarly as some other viral exanthemas under the diagnosis "other viral infections affecting the skin and mucosae, not listed elsewhere" (b08). analysis of the epidemiological position in the czech republic in 1993-1995 was based on epidat data, documentation of epidemic of 1993 in the liberec district and serologically confirmed minor epidemics (1994, 1995). an increased number of cases (in particular in ... | 1997 | 9162451 |
| dot immunoperoxidase assay for detection of parvovirus b19 antigens in serum samples. | we describe a simple and rapid dot immunoperoxidase assay for the direct detection of parvovirus b19 capsid antigens in human sera. the assay was performed with serum specimens dotted onto nylon membranes. vp1 and vp2 b19 antigens, which represent 4 and 96% of the capsid, respectively, were detected with a pool of monoclonal antibodies directed against the two proteins, and the complex was visualized by immunoperoxidase staining. the assay could be performed in about 4 h, and positive results we ... | 1997 | 9163485 |
| parvovirus b19 associated neutropenia. treatment with rh g-csf. | in a 39-year-old patient under follow-up for metastatic adenocarcinoma of the colon, a post-operative fever and a profound neutropenia occurred during hospitalization. a diagnosis of primary infection with parvovirus b-19 was made in view of the association of reticulocytopenia, together with anti-b19 igm antibodies and positive serum results for viral dna. the granulocytic lineage appeared to be normal on bone-marrow smears, and anti pmn autoantibodies were not found. rh g-csf therapy resulted ... | 1997 | 9168305 |
| [molecular biology at the service of the daily medical virology. 2. applications to virological diagnosis]. | molecular biology techniques are applied for the diagnosis of meningoencephalitis due to herpesviruses, enteroviruses or polyomaviruses, for the diagnosis of human cytomegalovirus, human parvovirus b19, varicella-zoster virus and rubella virus infections occurring during pregnancy, for the diagnosis and the management of retrovirus infections (hiv and htlv) and of hepatitis (hbv and hcv), for papillomavirus typing and to detect a link between virus and clinical manifestations (cardiomyopathy or ... | 1997 | 9180961 |
| antibodies to recombinant human erythropoietin causing pure red cell aplasia. | recombinant human erythropoietin (rhuepo) is used extensively in anemic patients on dialysis and other patients and is regarded as very safe and effective in the management of anemia in these patients. to date, there is no report on the development of antibodies to rhuepo in the patients treated with this drug. we report here a patient who developed antibodies to rhuepo and as a result developed pure red cell aplasia. a 63-year-old black male with end-stage renal disease secondary to hypertensio ... | 1997 | 9181281 |
| primary and secondary infections by human parvovirus b19 following bone marrow transplantation: characterization by pcr and b-cell molecular immunology. | due to the preparative regimen necessary, bone marrow transplantation (bmt) consistently results in severe immunodeficiency, often associated with anaemia, leukopenia and thrombocytopenia. parvovirus b19 replicates in red blood cell precursors in the bone marrow and causes erythema infectiosum ('fifth disease'), anaemia, arthritis and foetal death. we assessed the significance of b19 infections as a cause of post-bmt complications. over 900 serial serum samples from 201 allogeneic bone marrow re ... | 1997 | 9181647 |
| [atypical clinical manifestation in a child with parvovirus b19 infection]. | 1997 | 9183414 | |
| viruses and childhood arthritis. | the role of viral infections in the aetiology of acute and chronic arthritides of childhood is incompletely understood. the fact that some viruses cause acute arthritis is certain, although in most instances of presumed viral arthritis no agent is identified. the associations of viruses with diseases such as juvenile chronic arthritis (jca) are limited, and have been difficult to prove with certainty. rubella, parvovirus b19 and influenza ah2n2 have been shown by culture, serology or epidemiolog ... | 1997 | 9187231 |
| persistence of antibody to human parvovirus b19 after allogeneic bone marrow transplantation: role of prior recipient immunity. | human parvovirus b19 (b19) igg was studied retrospectively in 66 allogeneic bone marrow transplantation (bmt) patients using an enzyme-linked immunosorbent assay. recipient and donor sera had been stored pre-bmt together with sequential sera thereafter. approximately half of donors and recipients had anti-b19 igg pre-bmt and thus the relative contributions of donor and recipient immunity to antibody production after transplantation could be assessed. for each patient, a serum taken 2 to 3 years ... | 1997 | 9192791 |
| chronic parvovirus b19 infection resulting in chronic fatigue syndrome: case history and review. | the spectrum of disease caused by parvovirus b19 has been expanding in recent years because of improved and more sensitive methods of detection. there is evidence to suggest that chronic infection occurs in patients who are not detectably immunosuppressed. we report the case of a young woman with recurrent fever and a syndrome indistinguishable from chronic fatigue syndrome. after extensive investigation, we found persistent parvovirus b19 viremia, which was detectable by polymerase chain reacti ... | 1997 | 9195056 |
| chronic anemia as a complication of parvovirus b19 infection in a pediatric kidney transplant patient. | this is a report of unexplained anemia that persisted for 4 months in an adolescent renal transplant patient receiving immunosuppression that included prednisone, tacrolimus, and mycophenolate mofetil. this patient required monthly blood transfusions for fatigue, palpitations, and hematocrit levels between 15% and 17%. in addition, his posttransplant course was notable for the development of insulin-dependent diabetes mellitus. while receiving low-dose prednisone, he was switched from tacrolimus ... | 1997 | 9203192 |
| clinical relevance of parvovirus b19 as a cause of anemia in patients with human immunodeficiency virus infection. | parvovirus b19 (b19) dna was detected by dot blot hybridization in sera from 5 (17%) of 30 human immunodeficiency virus (hiv)-infected patients with hematocrits (hct) of < or =24 and 4 (31%) of 13 hrv-infected patients with hct of < or =20, suggesting that b19 is a reasonably common cause of severe anemia in hiv infection. the anemia promptly remitted after immunoglobulin therapy in 3 of 4 treated patients. the presence of igm to b19, the clinical circumstance in which anemia developed, and the ... | 1997 | 9207380 |
| [a girl with systemic onset juvenile rheumatoid arthritis suspected to be due to human parvovirus b19 infection]. | we encountered a case of a girl where human parvovirus b19 infection was considered to have been concerned with the development of systemic type juvenile rheumatoid arthritis (jra). while the affected child did not show any evident infectious erythema-like findings, changes in the serum antibody titer by the eia method presented the pattern of first infection. during the clinical course the condition of the disease as jra was serious and hemophagocytic syndrome developed concurrently. furthermor ... | 1997 | 9209130 |
| association of parvovirus infection with isolated fetal effusions. | the association of parvovirus b19 infection and hydrops fetalis is well known. however, the association of parvovirus and fetal pleural or pericardial effusions has not been reported. we present five cases of isolated pleural or pericardial effusion with documented maternal parvovirus infection in four of these pregnancies. in the absence of structural or karyotypic abnormalities, spontaneous resolution of the effusion portends for a successful pregnancy outcome. | 1997 | 9217958 |
| nonimmune hydrops fetalis caused by intrauterine human parvovirus b19 infection: a case of spontaneous reversal in utero. | we report a case of spontaneous reversal in utero of hydrops fetalis caused by parvovirus b19 maternal-fetal infection. the route leading to fetal hydrops is not fully understood. severe anemia with hypoxemia and viral fetal myocarditis have been incriminated. then the main issue is fetal death or spontaneous abortion. cases of spontaneous reversal of hydrops fetalis are unusual. fetal regenerative anemia is a good prognostic factor and emphasizes the place of conservative management. | 1997 | 9218942 |
| increased incidence of parvovirus b19. | 1997 | 9219425 | |
| detection of parvovirus b19-specific igm by antibody capture radioimmunoassay. | a solid phase igm-capture radioimmunoassay (macria) for the detection of parvovirus b19-igm is described (cohen et al., 1983, j. hyg. camb. 91, 113-130). igm from a dilution of patients serum is 'captured' onto a solid phase coated by anti-human igm. to determine whether any of the igm is specific for parvovirus b19, b19 antigen is added followed by a detector system. in the macria described here the detector system comprises a mouse monoclonal antibody to parvovirus b19 and a 125i-labelled anti ... | 1997 | 9220384 |
| human parvovirus b19 in bone marrows from adults with acquired immunodeficiency syndrome: a comparative study using in situ hybridization and immunohistochemistry. | human parvovirus b19, which infects and lyses erythroid precursors, can cause severe anemia in patients with immunodeficiency. the incidence of parvovirus infection in adult acquired immunodeficiency syndrome (aids) patients is unknown. eighty-one archival formalin-fixed, paraffin-embedded (ffpe) bone marrow biopsies from 73 aids adults were immunostained with monoclonal r92f6 against b19 vp1 and vp2 capsid proteins using streptavidin peroxidase and streptavidin alkaline phosphatase techniques. ... | 1997 | 9224741 |
| unexpected second trimester pregnancy loss due to maternal parvovirus b19 infection. | five unexplained second trimester fetal deaths occurring in a 3-month interval were evaluated to determine whether the fetal demise was associated with maternal infection due to parvovirus b19. one fetus was markedly hydropic, a classic finding of fetal infection; no gross anomalies were present in the other four. liver specimens from all five fetuses showed viral inclusions by light microscopy, supporting the presence of fetal parvovirus b19 infection. none of the five women had a history of pa ... | 1997 | 9225892 |
| viral arthritis. | viral infections are important in rheumatic disease not only because of the acute and subacute syndromes they cause but also because of their potential importance as etiologic factors in common chronic diseases such as rheumatoid arthritis. during 1996, the clinical spectrum of the acute polyarthritis caused by parvovirus b19 was further delineated and was shown to include carpal tunnel syndrome, hepatic dysfunction, and possibly angioedema. b19 infection can be studied using the salivary antibo ... | 1997 | 9229181 |
| [synchronous variations in the incidence of temporal arteritis and polymyalgia rheumatica in danish counties. association with epidemics of mycoplasma pneumonia infection]. | the incidences of temporal arteritis and polymyalgia rheumatica during a twelve year period were studied in different regions of denmark. data concerning the incidences of these diagnoses were obtained from two general hospitals from 1982 to 1994 and from the national patient register of all diagnoses from all hospitals in 13 of 16 danish counties from 1982 til 1993. data from all temporal artery biopsies in two counties were also obtained. serological epidemiological surveillance data concernin ... | 1997 | 9229871 |
| aplastic anemia due to b19 parvovirus infection in cadaveric renal transplant recipients: an underestimated infectious disease in the immunocompromised host. | parvovirus b19 has been identified as the etiological agent of "fifth disease" in childhood. it is also a rarely reported cause of anemia in transplanted patients. during a period of 18 months we observed four cases (2 male and 2 female; 53 +/- 4.24 years) of severe aplastic anemia due to parvovirus b19 in kidney transplant patients. the overall incidence of the disease was 6.3% of all our transplanted patients. symptoms of the disease occurred 22.5 +/- 9.75 days post-operatively. serum creatini ... | 1997 | 9238623 |
| serum antibodies to parvovirus b19 in patients with pityriasis rosea. | 1997 | 9252763 | |
| zoonotic and viral infection in fetal loss after 12 weeks. | one hundred and thirty-six women from an urban, rural and farming community were recruited to a study of infectious causes of midtrimester miscarriage (n = 85), stillbirth (n = 32), or termination for developmental (n = 17) or chromosomal (n = 2) abnormalities. no woman had evidence of acute infection with toxoplasma, listeria, leptospira or chlamydia psittaci (ovine enzootic abortion). one woman had midtrimester miscarriage associated with primary cytomegolovirus infection and five women had ev ... | 1997 | 9255087 |
| transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant b. | transient erythroblastopenia of childhood (tec) is a disorder of young children ages 3 months to 4 years that is characterized by anemia associated with reticulocytopenia and decreased red blood cell precursors in the bone marrow aspirate (bma). a viral cause has been suspected for tec. bone marrow aspirate-derived dna from 14 children with anemia or another hematologic disorder, including two children with tec, were analyzed by polymerase chain reaction for human herpesvirus type 6 (hhv-6) dna ... | 1997 | 9260752 |
| bacteremia caused by helicobacter cinaedi in an aids patients. | helicobacter cinaedi bacteremia has been infrequently described in homosexual patients with hiv infection. it may recur despite appropriate antimicrobial therapy. we report a bisexual patient with aids in whom h. cinaedi bacteremia developed and presented with prolonged fever and chronic diarrhea. the symptoms resolved without relapse after intravenous immunoglobulin therapy, which was administered for the treatment of concurrent parvovirus b19-associated anemia, and subsequent treatment with cl ... | 1997 | 9262063 |
| pure red cell aplasia due to parvovirus b19 infection in solid organ transplantation. | human parvovirus b19 disease is an infrequent but recognized rare cause of anemia in immunocompromised patients. a few cases of parvovirus b19 infections have been reported in transplant recipients, of those only four patients underwent renal transplantation. the primary immunosuppressive therapy in these patients included prednisone with either cyclosporine or tacrolimus. in one patient the disease was self-limiting, while in three others the hematocrit improved following 10-15 d of treatment w ... | 1997 | 9267713 |
| infection by parvovirus b 19 during pregnancy: a review. | fetal infection by parvovirus b 19 is a common cause of fetal anemia and nonimmune hydrops fetalis and may result in fetal death. recent improvements in diagnosing parvovirus infections by sensitive molecular biology techniques now allow for a new insight into its pathogenic rule, immunology, and the varied clinical manifestations. the estimated overall risk of fetal loss after maternal exposure is about 6.5 percent, which is much less than previously thought. inasmuch as complete spontaneous re ... | 1997 | 9095492 |
| other viral agents of perinatal importance. varicella, parvovirus, respiratory syncytial virus, and enterovirus. | this article summarizes new information on the natural history of maternal varicella and maternal parvovirus b19. controversies in the therapy of respiratory syncytial virus are presented. prophylactic and therapeutic immunotherapy of neonatal enteroviral disease are reviewed. | 1997 | 9099510 |
| late onset of hydrops fetalis following intrauterine parvovirus b19 infection. | we present a case of intrauterine parvovirus b19 infection, diagnosed by detection of b19 dna in the amniotic fluid obtained at 15 weeks of gestation for chromosome analysis in an asymptomatic pregnancy, causing hydrops fetalis 7 weeks later. following intrauterine transfusion, rapid resolution of hydrops could be observed and a healthy boy was born at 38 weeks of gestation. the respective laboratory data obtained from the examination of the amniotic fluid and maternal, fetal, and neonatal blood ... | 1997 | 9101221 |
| microbial dna in the synovium--a role in aetiology or a mere bystander? | 1997 | 9107236 | |
| persistence of parvovirus b19 dna in synovial membranes of young patients with and without chronic arthropathy. | human parvovirus b19 replicates in erythroid precursors of the bone marrow, and several diseases have been attributed to this virus including some cases of juvenile chronic arthropathy. | 1997 | 9107245 |
| reactive arthritis in a patient with simultaneous parvovirus b19 infection and clostridium difficile diarrhoea. | 1997 | 9117160 | |
| parvovirus b19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (kikuchi's disease). | a 15-year-old girl developed a haemophagocytic syndrome caused by human parvovirus b19 (pvb19). the cervical lymph node histology, resembling that of histiocytic necrotizing lymphadenitis (hnl, kikuchi's disease), included several transformed lymphocytes, numerous histocytes, and massive necrosis. we detected pvb19-positive cells in the lymph node by immunohistochemistry. possible autoimmune mechanisms in hnl-like diseases triggered by pvb19 are discussed. | 1997 | 9074434 |
| human parvovirus b19 infection associated with severe acute perimyocarditis in a 34-year-old man. | 1997 | 9076392 | |
| detection of human parvovirus b19 dna in cerebrospinal fluid. | 1997 | 9076823 | |
| virus inactivation of blood products by phenothiazine dyes and light. | methylene blue (mb) and its derivatives azure a, b, c and thionine are photoactive and, in principle, are suitable for photodynamic virus inactivation of blood and blood products, such as therapeutic plasma. methylene blue was selected for plasma decontamination because it is being clinically used and because of its known toxicological and other properties. the standard procedure for photodynamic treatment of single units of fresh plasma involves illumination with visible light at an mb concentr ... | 1997 | 9077128 |
| parvovirus b19 in human disease. | parvovirus b19, the only known human pathogenic parvovirus, is associated with a wide range of disease manifestations. in healthy individuals, the major presentation of b19 infection is erythema infectiosum. in patients with underlying hemolytic disorders, infection is the primary cause of transient aplastic crisis. in immunosuppressed patients, persistent infection may develop that presents as pure red cell aplasia and chronic anemia. in utero infection may result in hydrops fetalis or congenit ... | 1997 | 9046945 |
| life-threatening anaemia caused by b19 parvovirus infection in a non-immunocompromised patient. | a 21-year-old surinam boy suffering from a combined heterozygous sickle-cell beta-thalassaemia presented with an extreme anaemia (haemoglobin concentration 0.7 mmol/l) and severe haemolysis without signs of increased erythropoiesis. an acute b19 parvovirus infection was diagnosed by a transient increase of igm anti-b19 parvovirus titres and a positive polymerase chain reaction for b19 parvovirus. the patient recovered spontaneously after a short period of supportive care with red cell transfusio ... | 1997 | 9050335 |
| toxoplasmosis and parvovirus b19. | pregnant women might well improve their chances for a successful pregnancy outcome by following the advice of w. c. fields: avoid contact with small children and animals whenever possible. failing widespread acceptance of this philosophy, management of t. gondii and parvovirus b19 infections continues to be a challenge for the foreseeable future. | 1997 | 9067784 |
| similarities of specificity and cofactor dependence in serum antiphospholipid antibodies from patients with human parvovirus b19 infection and from those with systemic lupus erythematosus. | to assess the phospholipid specificity and immunoglobulin isotype of antiphospholipid (apl) antibodies in patients with acute parvovirus b19 infection. | 1997 | 9008606 |
| establishment of a cell line expressing human parvovirus b19 non-structural protein from an inducible promoter. | human parvovirus b19 non-structural (ns) protein is supposed to play a major role in b19 replication and transcription, and therefore in b19 pathogenicity. constitutive expression of ns protein in stable cell lines has failed so far, presumably because of its cytotoxicity. to avoid this cytotoxic effect, we have cloned the ns gene in an epstein-barr virus episomal vector under the control of a steroid inducible promoter (5xgre) and transfected this construction into hela cells. we obtained stabl ... | 1997 | 9010306 |
| diagnostic value of cd45ro expression on circulating t lymphocytes of fetuses and newborn infants with pre-, peri- or early post-natal infections. | we examined the expression of the cd45ro antigen, which characterizes the antigen primed/memory phenotype of t lymphocytes, as a marker for congenital infection in blood samples of newborns and fetuses. cd45ro expression on t cells was determined by triple-colour fluorescence flow cytometry. in total 537 blood samples of newborns and infants up to an age of 3 months and 89 fetal blood samples from gestational weeks 19-31 were analysed. of the newborns and infants, 74 had a clinically, serologica ... | 1997 | 9030868 |
| human parvovirus b19 and blood products. | human b19 parvovirus (b19), identified in 1975, was only recognised as the causative agent of fifth disease in 1983. the incidence of viraemia is low, around 1 in 1,000, but is sufficient to ensure that most plasma pools for fractionation contain some virus. while infection usually occurs in childhood and is benign, chronic infection sometimes occurs and may be of concern in certain patient groups. | 1997 | 9031493 |
| new molecular diagnostic tests for two congenital forms of anemia. | congenital hypoplastic anemias are a rare and heterogeneous group of disorders. this paper reviews new molecular diagnostic tests in two distinct forms of congenital anemias, anemia due to transplacental infection with b19 parvovirus and fanconi anemia. in both instances, molecular assays making use of amplification of dna by the polymerase chain reaction have been used to diagnose either a specific viral infection or gene mutation responsible for a disorder. recognition of these entities has im ... | 1997 | 9021520 |
| serological and virological markers of human parvovirus b19 infection in patients with haemophilia. | clotting factor concentrates prepared from human plasma are a potential route of parvovirus b19 (b19) infection in patients with coagulation disorders. however, it is not clear whether b19 transmits and persistently infects patients with haemophilia, especially those with hiv infection. we examined serological and virological markers of b19 in samples from 40 patients with haemophilia who had been receiving several brands of clotting factor concentrates. all of them were anti-b19 igg seropositiv ... | 1997 | 27214724 |
| parvovirus b19-induced constellation of acute renal failure, elevated aminotransferases and congestive heart failure. | this report details a case of acute renal failure and elevated aminotransferases with subsequent development of congestive heart failure in a patient with history of exposure to parvovirus b19 and serological evidence of acute infection with this agent. this constellation of organ involvement has not been previously reported in the literature. | 1997 | 22514477 |
| diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases. | primary autoimmune neutropenia (ain) is caused by granulocyte-specific autoantibodies and occurs predominantly in infancy. clinical presentation and diagnosis have not been well established, resulting in burdening diagnostic investigations and unnecessary treatment with granulocyte colony-stimulating factor (g-csf). in the present study, clinical, laboratory, and immunologic data of 240 infants with primary ain were evaluated. suspected association with parvovirus b19 infection was investigated ... | 1998 | 9414283 |
| characterization of cis-acting and ns1 protein-responsive elements in the p6 promoter of parvovirus b19. | parvovirus b19 infections are associated with diverse clinical manifestations, ranging from no symptoms to severe symptoms. the virus shows an extreme tropism for replication in erythroid progenitor cells, possibly due to the activity of the only functional promoter (p6) of the b19 virus genome in combination with both cell- and cell cycle-specific factors and the trans-activator protein ns1. as presented here, p6 promoter sequences derived from several b19 virus isolates proved to be highly con ... | 1998 | 9420265 |
| antenatal parvovirus infection: clinical implications. | 1998 | 9509501 | |
| hepatitis-associated aplastic anemia and acute parvovirus b19 infection: a report of two cases and a review of the literature. | hepatitis-associated aplastic anemia is rare in general, but occurs in up to 28% of patients receiving liver transplantation for fulminant non-a, non-b hepatitis. cases are commonly young men with mild hepatitis but severe aplastic anemia. although cases have been reported in association with hepatitis a, b, and c, most appear to be due to a non-a-b-c virus. we report two cases of acute hepatitis subsequently complicated by marrow hypoplasia in patients with acute parvovirus b19 infection. hepat ... | 1998 | 9517662 |
| persistence of parvovirus b19 dna in testis of patients with testicular germ cell tumours. | germ cell tumours (gct) of the testis are the most common malignant tumours occurring in young adults. in view of the young age of patients, the increasing incidence of gct and the overexpression of wild-type p53 observed in a majority of tumours, the possibility of the involvement of a virus in the development of this cancer was considered. testicular gct were analysed for the presence of cytomegalovirus and epstein-barr virus (ebv), which are known to cause overexpression of wild-type p53 prot ... | 1998 | 9519836 |
| prevalence of parvovirus b19 infection among patients with human immunodeficiency virus infection in barcelona, spain. | 1998 | 9521236 | |
| [parvovirus b19--a cause of hepatitis in patients with liver transplantation, anemia in hiv positive individuals and encephalopathies in children]. | 1998 | 9522660 | |
| human parvovirus b19 nonstructural (ns1) protein induces apoptosis in erythroid lineage cells. | infection of erythroid-lineage cells by human parvovirus b19 is characterized by a gradual cytocidal effect. accumulating evidence now implicates the nonstructural (ns1) protein of the virus in cytotoxicity, but the mechanism underlying the ns1-induced cell death is not known. using a stringent regulatory system, we demonstrate that ns1 cytotoxicity is closely related to apoptosis, as evidenced by cell morphology, genomic dna fragmentation, and cell cycle analysis with the human erythroleukemia ... | 1998 | 9525624 |
| regulation of human b19 parvovirus promoter expression by hgabp (e4tf1) transcription factor. | the genetic expression of human b19 parvovirus is only dependent on one promoter in vivo and in vitro. this is the p6 promoter, which is located on the left side of the genome and is a single-stranded dna molecule. this led us to investigate the regulation of the p6 promoter and the possible resulting variability of the nucleotide sequence. after analysis of the promoter region of 17 b19 strains, only 1.5% variability was found. more exciting was the finding of mutations that were clustered arou ... | 1998 | 9525935 |
| [the blood-born viral infections]. | recently it has become urgent to establish a risk control system against emerging and re-emerging infectious diseases. many of the emerging and re-emerging infectious diseases such as aids and viral hepatitis, are induced by viral infection via blood. the main causative agents of blood-born viral infection are hepatitis b virus (hbv), hepatitis c virus (hcv), human immunodeficiency virus (hiv), human t cell leukemia virus type1 (htlv1), cytomegalovirus (cmv), epstein-barr virus (ebv), and human ... | 1998 | 9528333 |
| raised igm antibodies to parvovirus b19 in juvenile rheumatoid arthritis. | to delineate the role of human parvovirus b19 in the etiopathogenesis of juvenile rheumatoid arthritis (jra), igm and igg antibodies specific for parvovirus b19 surface protein antigen(s) were estimated in the sera using commercial elisa kits. sera of 69 jra patients (median age 16 yr, male : female ratio 1.1:1) satisfying the criteria of american rheumatism association along with 26 sera of rheumatoid arthritis (ra) and 12 sera of healthy children as disease and normal controls respectively wer ... | 1998 | 9529776 |
| evaluation of parvo b19, cmv and hpv viruses in human aborted material using the polymerase chain reaction technique. | to investigate the role of human parvovirus b19 (parvo b19), cytomegalovirus (cmv) and human papilloma virus (hpv) viruses in the aetiopathogenesis of spontaneous abortions. | 1998 | 9481569 |
| human parvovirus b19 dna detected by receptor-mediated hemagglutination assay of pooled plasma for fractionation. | 1998 | 9482405 | |
| prospective evaluation of 618 pregnant women exposed to parvovirus b19: risks and symptoms. | to assess the risk of maternal parvovirus b19 infection from exposure to various sources and the fetal morbidity of those infections. | 1998 | 9491870 |
| a clinical and epidemiological study of human parvovirus b19 infection in fetal hydrops using pcr southern blot hybridization and chemiluminescence detection. | ninety-eight samples from 80 cases of spontaneous abortions after fetal death or hydrops fetalis from 12,000 pregnant women were examined using pcr. dna was extracted from amniotic fluid, fetal blood, ascitic fluid and fetal biopsies or placenta specimens using qia amp kits (qiagen). a 270-bp length fragment located within the b19 gene ns1 was amplified using pcr followed by electrophoresis and southern-blot hybridization assay using a horseradish peroxidase-labelled probe and chemiluminescence ... | 1998 | 9496373 |
| petechial gloves and socks syndrome caused by parvovirus b19. | this report describes a 14-year-old boy with petechial gloves and socks syndrome associated with acute parvovirus b19 infection. this represents only the second child reported with this distinctive exanthem. | 1998 | 9496801 |
| testing for parvovirus b19 in henoch-schönlein syndrome? | 1998 | 9496814 | |
| immediate and long term outcome of human parvovirus b19 infection in pregnancy. | to estimate more precisely the risk of fetal loss and congenital abnormalities after maternal parvovirus b19 infection, and to assess the long term outcome for surviving infants. | 1998 | 9501782 |
| life-threatening parvovirus b19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. | parvovirus b19 infection can cause a wide spectrum of disease syndromes. two cases of parvovirus b19 infection were identified that resulted in life-threatening myocarditis shortly after acute infection in immunocompetent individuals. the diagnosis was made with serological and polymerase chain reaction techniques. one patient was successfully treated by heart transplantation. sequence analysis showed that the parvovirus b19 cloned from the patients' sera had 99% homology with the prototype sequ ... | 1998 | 9502455 |
| long-term outcome of children following maternal human parvovirus b19 infection. | to determine the long-term outcomes of children exposed in utero to maternal parvovirus b19 infection. | 1998 | 9464735 |
| [diagnosis of human parvovirus b19 infection in nonimmune hydrops fetalis]. | parvovirus b19 (pv b19) infection was investigated in 29 pregnant women with fetal hydrops, after exclusion of feto-maternal incompatibility within red blood cell antigens, torch infections, feto-maternal hemorrhage and genetics reasons. the active viral infection was detected in 9 women (31%) by pcr amplification of dna b19; in 2 of them igm and igg, in 1 igm and in 4 igg antibodies were also present. in 6 women (20%) igg antibodies were only found, but not igm and dna b19, which confirmed infe ... | 1998 | 9640861 |
| [human parvovirus b19-induced aplastic crisis in a case with spherocytosis]. | a 43-year-old female with spherocytosis was admitted to the hospital because of fever, headache, and rapidly progressive anemia. on admission, she had severe anemia (hb 3.9 g/dl) with marked decrease in reticulocytes (0.3%). some premature leukocytes, such as promyerocyte, were observed in the peripheral blood. bone marrow smear revealed normocellular marrow with normal presence of erythroid cells. anti-human parvovirus b19 igm and igg antibody was positive in the serum on admission. the dna of ... | 1998 | 9642948 |
| acute parvovirus b19 infection in pregnant women--an analysis of serial samples by serological and semi-quantitative pcr techniques. | the serological and virological course of parvovirus b19 infection was followed in 14 women who suffered symptomatic or subclinical acute infection during pregnancy. serial serum samples from the patients were tested for igg and igm antibodies and the levels of parvovirus b19 dna were monitored using a semi-quantitative pcr assay. in addition, the outcome of the pregnancies was documented by clinical information and by testing cord blood for parvovirus b19 specific antibodies as well as for parv ... | 1998 | 9646103 |
| [seroprevalence versus parvovirus b19 in blood donors]. | the aim of the study was to describe the seroprevalence against parvovirus b19 in a random sample of blood donors in the hospital universitario de salamanca. | 1998 | 9646558 |
| human parvovirus b19 as a causative agent for rheumatoid arthritis. | human parvovirus b19 (b19) dna was detected in the synovial tissues in 30 of 39 patients with rheumatoid arthritis (ra), and infrequently in those with osteoarthritis and traumatic joints. on the other hand, the expression of the b19 antigen vp-1 was specific (27/27) in ra synovium with active synovial lesions, but not in osteoarthritis and controls. the target cells of b19 were macrophages, follicular dendritic cells, t cells, and b cells, but not synovial lining cells in the synovium. b19-nega ... | 1998 | 9653169 |
| serologic and virologic evidence for frequent intrauterine transmission of human parvovirus b19 with a primary maternal infection during pregnancy. | to define the intrauterine viral transmission rate during primary maternal parvovirus b19 infection and identify factors that may influence this rate. | 1998 | 9655540 |
| a case of guillain-barré syndrome associated with human parvovirus b19 infection. | we report a 4-year-old boy who presented with guillain-barré syndrome 11 days after the onset of erythema infectiosum. the illness resolved without gamma globulin therapy. | 1998 | 9661947 |
| immunogold probes in electron microscopy. | 1998 | 9664388 | |
| intra-uterine parvovirus b19 infection and meconium peritonitis. | b19 fetal infection has been associated with hydrops or fetal death. we report four cases of meconium peritonitis in hydropic fetuses with laboratory diagnosis of b19 infection. parvovirus b19 dna was detected by in situ hybridization both in cord blood and in amniotic cells in three fetuses, while in one case only cord blood was available and proved positive. signs of active or recent b19 infection in maternal serum samples were documented only in two cases, which proved positive for specific i ... | 1998 | 9664606 |
| frequency of parvovirus b19 infection in nonimmune hydrops fetalis and utility of three diagnostic methods. | the rate of parvovirus b19 (pv) infection in cases of "idiopathic" nonimmune hydrops fetalis (nihf) is reported to be approximately 16% with polymerase chain reaction (pcr)-based methods. antibodies for use in paraffin-embedded tissue have not been systematically compared with pcr or with the presence of inclusions at varying gestational ages. all autopsy cases of nihf and those with effusions of multiple serous membranes examined between 1991 and 1996 (n = 29) were evaluated for the presence of ... | 1998 | 9670826 |
| papular-purpuric gloves and socks syndrome associated with acute parvovirus b19 infection: case report and review. | the papular-purpuric gloves and socks syndrome (ppgss) was first described in 1990. this syndrome is characterized by fever, acral pruritus, edema, petechiae, and oral erosions. subsequently, parvovirus b19 has been implicated, in most cases, as the causative agent of this syndrome. to date, with two exceptions, all published cases of ppgss have been from europe and the middle east and have been mainly reported in the dermatology literature. herein, we report what we believe to be only the secon ... | 1998 | 9675471 |
| [parvovirus b19 infection--a meningococcus-like sepsis]. | two otherwise healthy adults with fever and haemorrhagic exanthema are described. in both, primary human parvovirus infection was diagnosed. the clinical picture of fever and haemorrhagic exanthema should always arouse suspicion of serious disease such as meningococcal infection. if the patient is unaffected, however, primary human parvovirus infection should be borne in mind. | 1998 | 9679439 |
| persistent b19 parvovirus infection in pediatric malignancies. | the frequency and clinical importance of parvovirus b19 infection were studied in children investigated or treated for various malignancies and cytopenias. | 1998 | 9680929 |
| failure in detection of epstein-barr virus and cytomegalovirus in specimen obtained by fine needle aspiration biopsy of thyroid in patients with subacute thyroiditis. | to study the possible role of viral infection in the etiology of subacute thyroiditis (sat), we measured serum virus-specific antibodies to measles, rubella, mumps, type i herpes, chicken pox, human parvovirus b19 and cytomegalovirus (cmv) in 10 patients with sat during the course of illness. in spite of the presence of igg to each virus in more than 70% of patients, no significant changes in the igg titers were observed except those to measles, rubella, chicken pox or cmv in only 10% of patient ... | 1998 | 9915102 |
| parvovirus b19 infection in pregnancy. | transplacental transmission of human parvovirus b19 (b19 virus) to the fetus is an important cause of intrauterine death, abortion, stillbirth, and nonimmune hydrops fetalis. adverse outcome of pregnancy can occur after symptomatic and asymptomatic maternal infection. only rare cases of congenital malformations and fetal disease in live-born infants have been associated with intrauterine b19 virus infection. laboratory results obtained from paired maternal and fetal cord blood samples indicate t ... | 1998 | 10213893 |
| parvovirus b19 infection associated with myocarditis following adult cardiac transplantation. | a 56-year-old woman underwent an uneventful cardiac transplantation due to dilated cardiomyopathy. one week later the patient developed clinical and histological signs of myocarditis. we report for the first time a case of myocarditis in an adult heart transplant recipient, possibly induced by parvovirus b19, as evidenced by the finding of specific igm in serum and specific dna in the myocardial cells. furthermore, this is the first time parvovirus b19 dna has been observed in the myocardium of ... | 1998 | 10225391 |
| resolution of human parvovirus b19-induced nonimmune hydrops after intrauterine transfusion. | our objective is to report our experience with cases of prolonged recovery from nonimmune hydrops secondary to human parvovirus b19 infection occurring after intrauterine transfusion. we reviewed cases referred to our unit over a 10 year period for exposure to parvovirus b19 infection. those cases with serologic evidence of recent infection were identified. the cases requiring intrauterine transfusion were reviewed for demographic details, time of exposure, parvovirus b19 serology, gestational a ... | 1998 | 9733171 |
| human parvovirus b19 infection in persons with haemophilia. | 1998 | 9716173 | |
| neuralgic amyotrophy and polyarthritis caused by parvovirus b19 infection. | 1998 | 9709194 | |
| detection of parvovirus b19 in macerated fetal tissue using in situ hybridization. | 1998 | 9659278 | |
| papular acrodermatitis of childhood related to poxvirus and parvovirus b19 infection. | papular acrodermatitis of childhood (gianotti-crosti syndrome) is considered an unspecific cutaneous pattern related to an increasing number of infectious diseases. we report two cases of gianotti-crosti syndrome, one of which occurred in the setting of parvovirus b19 primary infection and the other followed poxvirus infection. parvovirus b19 and poxvirus may represent new causative agents of gianotti-crosti syndrome. | 1998 | 9608338 |
| high prevalence of parvovirus b19 igg antibodies among dutch hemophilia patients. | human parvovirus b19 is a potential risk to hemophiliac patients receiving blood products. | 1998 | 9691402 |
| human parvovirus b19 antibodies are less frequent among patients treated with factor ix concentrate inactivated by ultrafiltration: a report from a single spanish institution. | 1998 | 9691409 | |
| congenital spherocytic hemolytic anemia in a family presenting with transient red cell aplasia from parvovirus b19 infection. | 1998 | 9692404 | |
| salivary diagnosis of rubella: a study of notified cases in the united kingdom, 1991-4. | rubella infections, notified by general practitioners on the basis of a clinical diagnosis, were investigated by testing blood and saliva samples for specific igm. overall 52 (29%) of 178 cases with appropriately timed blood specimens were confirmed as recent rubella by igm serology. only 2 (3%) of 74 cases in children under 5 years were confirmed compared to 50 (48%) of 104 cases in older children and adults. the confirmation rate was lower (6%) in those with documented vaccination history than ... | 1998 | 9692610 |
| parvovirus b19-induced anemia as the presenting manifestation of x-linked hyper-igm syndrome. | parvovirus b19 (b19) can cause chronic anemia due to persistent infection in immunocompromised hosts who cannot produce neutralizing antibody necessary for clearing b19. three patients with x-linked hyper-igm syndrome (xhim), who were all asymptomatic until they developed b19-induced chronic anemia at the ages of 8, 14, and 17 years, respectively, were found to have mutations of the cd40l gene, including a missense mutation (t254m), a nonsense mutation resulting in a new initiation codon and los ... | 1998 | 9697710 |
| b19 virus: an update. | 1998 | 9714022 | |
| foetal intracardiac transfusion for the treatment of severe anaemia due to human parvovirus b-19 infection. | intra-uterine parvovirus infection may result in severe foetal anaemia and death. ultrasound diagnosis of foetal parvovirus is presented, together with ultrasound-guided foetal transfusion to treat the anaemia. | 1998 | 9727267 |