Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| laminar distribution of alpha 1- and beta 1-adrenoceptors in ferret visual cortex. | the distribution of alpha 1- and beta 1-adrenoceptors has been examined in the ferret visual cortex (area 17), with an autoradiographic procedure using iodine-125 labeled hydroxy-iodophenyl-ethylaminomethyl-tetralone (heat) and iodocyanopindolol (icyp), respectively. the density of ligand binding with icyp, known to have selective affinity for beta-receptors, was heavy over layers i-iii, very low over layer iv, and medium over v and vi. in contrast, binding sites for heat, a new ligand selective ... | 1985 | 2986767 |
| autoradiographic analysis of adrenergic receptors in the mammalian brain. | noradrenaline (na) exerts its physiological and pharmacological effects in the central nervous system by interacting with specific receptor sites which are divided into four subtypes, namely alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors. alpha-1 and beta-1 receptors are thought to be neuronal and post-synaptic, whereas alpha-2-r are neuronal pre- and postsynaptic and beta-2-r have a non neuronal (glial, vascular) localization. the autoradiographic localization of adrenergic receptors is requ ... | 1985 | 2988261 |
| arginine deficiency, hyperammonemia and reye's syndrome in ferrets. | young male ferrets developed hyperammonemia and encephalopathy shortly after eating a diet lacking in arginine. the dietary supplementation of arginine or intraperitoneal injection of ornithine prevented hyperammonemia and shortened the duration of encephalopathy. therefore, young ferrets were assumed to be unable to meet their ornithine needs from sources other than arginine. adult ferrets did not develop hyperammonemia and encephalopathy after eating arginine-free diet. because young ferrets a ... | 1985 | 2991654 |
| the effects of milrinone and piroximone on intracellular calcium handling in working myocardium from the ferret. | the effects of milrinone and piroximone were compared to those of isoprenaline, dibutyryl adenosine 3':5'-cyclic monophosphate (dibutyryl cyclic amp), forskolin, isobutylmethylxanthine, increased extracellular calcium [( ca2+]o) and caffeine in ferret right ventricular papillary muscles that were loaded intracellularly with aequorin, a bioluminescent calcium indicator that emits light when it combines with calcium. the positive inotropic action of each drug, except caffeine, was associated with ... | 1985 | 2992656 |
| experimental transmission of aleutian disease virus (adv) to different animal species. | two animals from each of 8 different species (mink, finn raccoon, cat, dog, ferret, blue fox, mouse and rabbit) were inoculated with the highly virulent utah i strain of adv. only the mink developed hypergammaglobulinemia. all animals produced antibodies to adv antigens, but with different titres. mink sera had much higher antibody titres than the other animal sera. antibodies to the adv-coded, non-structural polypeptide (p71) were found in mink, finn raccoons and dogs only. presence of this kin ... | 1985 | 2994362 |
| in vitro metabolism of [3h]-peptide leukotrienes in human and ferret lung: a comparison with the guinea pig. | fragmented lung tissue prepared from human, ferret and guinea pig converted [3h]-leukotriene c4 ([3h]-ltc4) to [3h]-ltd4 and [3h]-lte4. [3h]-ltd4 was the major product recovered from incubations with human and guinea pig lung, whereas [3h]-lte4 was the predominant metabolite in ferret. kinetic analysis in human lung yielded a much faster rate for the conversion of [3h]-ltc4 to [3h]-ltd4+e4 than for the conversion of [3h]-ltd4 to [3h]-lte4. in all three species serine-borate complex blocked the m ... | 1985 | 2996529 |
| a comparative study of electrical field stimulation of the guinea-pig, ferret and marmoset urinary bladder. | the spontaneous and electrically evoked activity was examined in guinea-pig, ferret and marmoset urinary bladder. electrical field stimulation of detrusor strips in vitro induced a rapid, frequency-dependent contraction with a maximum response at 40 hz. this contraction was partly decreased by either atropine (0.29 microm) or desensitisation to alpha, beta-methylene atp (alpha, beta-meatp) (5 microm), and was totally blocked by a combination of the two. atropine blocked responses to carbachol (3 ... | 1985 | 2998810 |
| centrarchid fish as paratenic hosts of the giant kidney worm, dioctophyma renale (goeze, 1782), in ontario, canada. | infective larvae of dioctophyma renale were found in the hypaxial musculature of pumpkinseed (lepomis gibbosus l.) from three lakes in algonquin provincial park, ontario, canada. this represents the first report of d. renale in centrarchid fish. in the three lakes surveyed prevalence and mean intensity ranged from 5 to 23% and one to two larvae respectively. larvae elicited a mild granulomatous reaction in pumpkinseed. two ferrets were each given five larvae from pumpkinseed. adult d. renale wer ... | 1985 | 3157009 |
| the electrocardiogram of normal ferrets and ferrets with right ventricular hypertrophy. | sixty-eight electrocardiograms were recorded on ferrets (mustela putorius furo). these represent 29 normal weanling males, 19 normal adult males and 20 adult males with right ventricular hypertrophy (rvh). analyses of rate, rhythm, axis and total voltage were used to define the normal electrocardiogram (ecg) and to identify changes seen in rvh. the normal ferret has a heart rate of about 300 beats per minute and a mean electrical axis of + 86 degrees +/- 6.6 (sd). a 56% increase in right ventric ... | 1985 | 3160888 |
| altered calcium handling in experimental pressure-overload hypertrophy in the ferret. | the purpose of this study was to evaluate the relationship between changes in the intracellular handling of free, ionized calcium and the functional alterations that occur in cardiac hypertrophy. we developed a model of right ventricular pressure-overload hypertrophy in the ferret by critical banding of the pulmonary artery; this method produced significant degrees of hypertrophy within 1-3 months of surgery. we removed papillary muscles, 1 mm or less in diameter, from ferrets with cardiac hyper ... | 1985 | 2933178 |
| regional myocyte size in compensated right ventricular hypertrophy in the ferret. | the effect of pressure-induced right ventricular hypertrophy on regional myocyte size and shape and regional myocardial wet weight was studied by comparing 20 ferrets which underwent pulmonary artery banding at a weanling age to 19 non-operated siblings. using isolated myocyte preparations from six myocardial regions in 10 banded and seven non-banded ferrets, a 60% increase in cell volume in the right ventricular outflow tract and the right ventricular free wall was shown to be due primarily to ... | 1985 | 2933527 |
| [vaccination of ferrets (putorius furo) against rabies using a tissue vaccine]. | the use of live tissue rabies vaccine from vnukovo-32 strain produced by the bioveta national corporation at ivanovice na hané was tested on 15 ferrets (putorius furo l. 1758). the 21st day after subcutaneous application of 3 ml of vaccine, the average titre of virus-neutralizing antibodies was 1 : 71.4, and after subcutaneous and intramuscular application of 1 ml of vaccine the average titre was 1:20.6 and 1 : 15.6, respectively. the challenge test was performed 52 weeks after vaccination: a do ... | 1986 | 3083568 |
| acute effects of gnrf-induced gonadotrophin secretion upon ovarian steroid secretion in the ferret. | the effects of an increase in endogenous gonadotrophin secretion on the production of oestradiol, progesterone, androstenedione and testosterone by the ovaries of anaesthetized anoestrous and oestrous ferrets were followed. gonadotrophin secretion was enhanced by the injection of gonadotrophin releasing factor (gnrf), and serial blood samples were collected over 9 h for hormone assay. thyrotrophic hormone releasing factor (trf) or acetic acid were injected for control purposes. the plasma conten ... | 1986 | 3083626 |
| pulpal response to an experimental adhesion promoter. | the pulpal response to an experimental adhesion promoter (ptp) used in conjunction with a composite resin material, biogloss, is described, in lined and unlined cavities. dycal was the lining and negative control material. standardised class v cavities were prepared in ferret canine teeth and the pulpal responses studied after 1, 2 and 4 weeks and 6 months post-operatively. pre-treatment of cavities with ptp causes a reduction in pulpal inflammation at 7 and 14 days compared with biogloss. there ... | 1986 | 3088234 |
| penetration in vitro of human and ferret dentine by three bacterial species in relation to their potential role in pulpal inflammation. | 1986 | 3108162 | |
| biochemical and radioautographic analysis of estrogen-inducible progestin receptors in female ferret brain and pituitary: correlations with effects of progesterone on sexual behavior and gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone. | cytosolic binding molecules for the synthetic progestin [3h]r5020, were isolated in vitro from several brain regions including preoptic area/anterior hypothalamus, mediobasal hypothalamus, medial amygdala and parietal cortex as well as the pituitary gland of ovohysterectomized female ferrets. binding of [3h]r5020 to cortical cytosols was saturable, of high affinity (apparent dissociation constant of 2.0 nm), and was steroid specific. pretreatment of ferrets with a silastic capsule containing est ... | 1986 | 3516305 |
| combined light and electron microscope immunocytochemical localization of scattered peptidergic neurons in the central nervous system. | a pre-embedding immunocytochemical technique is described for combined light and electron microscope study of peptidergic neurons in the central nervous system. the protocol is especially designed to overcome the sampling problems inherent in electron microscope study of structures, such as luteinizing hormone-releasing hormone (lhrh) neurons, that are scattered individually across large brain regions. the fixation methods outlined for several mammalian species include immersion and vascular per ... | 1986 | 3518390 |
| variation among species in the endocrine control of mammary growth and function: the roles of prolactin, growth hormone, and placental lactogen. | prolactin, growth hormone, and placental lactogen form a family of structurally related hormones, which may have evolved from a common ancestral peptide. prolactin and growth hormone are present in all mammals, but the biological activity associated with placental lactogen has been detected in only some groups. attempts to detect placental lactogen using bioassay and radioreceptor assay are reported and have been unsuccessful in an insectivore (the shrew), a bat, an edentate (the armadillo), a l ... | 1986 | 3519707 |
| development of murine monoclonal antibodies to pneumocystis carinii. | relatively little is known about the antigenic structure of pneumocystis carinii and the immunopathogenesis of pneumonitis caused by p. carinii. to begin to define the antigenic character of the surface of this organism, we have produced murine monoclonal antibodies that react with the surface of p. carinii (obtained from rats), as detected by immunofluorescence and immunoelectron microscopy. immunoblot analysis revealed that the six antibodies described in this report bound an antigen with an a ... | 1986 | 3522758 |
| the ferret: a new model of oral ethanol injury involving the liver, bone marrow, and peripheral blood lymphocytes. | we have developed a model of oral ethanol ingestion in the ferret by providing a complete liquid diet in which 21% of the total caloric intake is given as ethanol. after 3 weeks of ethanol treatment, migration inhibitory factor activity from ferret lymphocytes was significantly decreased when compared to animals fed a dextrose-substituted, identical liquid diet. lymphocyte blastogenesis in response to the mitogen, phytohemagglutinin, was also decreased after 6 weeks of ethanol ingestion. histopa ... | 1986 | 3526951 |
| developmental changes in glycoconjugate secretion by ferret tracheas. | surface epithelium and submucosal glands of the ferret trachea undergo extensive postnatal development. this study examined developmental changes in rates of release and types of high molecular weight glycoconjugates secreted by explanted ferret tracheas. digestion with bovine testicular hyaluronidase separated the high molecular weight glycoconjugates into two types, hyaluronidase-resistant mucins and hyaluronidase-susceptible glycosaminoglycans. release rates were measured under unstimulated c ... | 1986 | 3532888 |
| evidence for dopaminergic regulation of prolactin and a luteotropic complex in the ferret. | the role of dopaminergic agents in prolactin (prl) release and the luteotrophic role of prl and luteinizing hormone (lh) were investigated in pseudopregnant female ferrets. a single injection of the dopamine antagonist pimozide (0.63 mg/kg) resulted in a tenfold elevation of plasma prl in anestrous females. subcutaneous injection of pimozide on alternate days from day 2 through day 16 of pseudopregnancy elevated both prl and progesterone levels. daily treatment with the dopamine agonist 2 alpha- ... | 1986 | 3539212 |
| the responses of simultaneously recorded purkinje cells to the perturbations of the step cycle in the walking ferret: a study using a new analytical method--the real-time postsynaptic response (rtpr). | experiments were performed in ambulating decerebrate ferrets to examine the activity of up to 6 simultaneously recorded purkinje cells oriented sagittally during unperturbed and perturbed locomotion using a new analytical technique, the real-time postsynaptic response (rtpr), which permits a trial-by-trial assessment of the action of the recorded neurons on a simulated cerebellar nuclear cell. the data illustrate that the responsiveness of the purkinje cells located in a specific region of lobul ... | 1986 | 3004660 |
| oestrogen modulates dopamine-controlled behaviours in the male ferret. | oestradiol (100 micrograms/kg) was administered to male ferrets on three successive days. two and three days after the last oestradiol injection the effects of apomorphine (0.5 mg/kg) on stereotyped, predatory and scent marking behaviour were intensified. thus, three days of oestradiol administration produced a supersensitive dopaminergic system two days after the last oestradiol injection. however, no initial antidopaminergic effect of oestradiol could be demonstrated one day after the last oes ... | 1986 | 3019737 |
| insulinoma in a ferret. | insulinoma was diagnosed in a 7-year-old female ferret examined because of generalized seizures, intermittent paraplegia, and abnormal behavior. low serum glucose, high serum insulin, and infinite amended insulin/glucose ratio values in this ferret supported the clinical diagnosis of insulinoma. histologic examination of the pancreas confirmed the diagnosis of insulinoma. the clinical signs and laboratory evaluations in this case and in a previously reported case of insulinoma in a ferret were c ... | 1986 | 3021697 |
| pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle. | the contractile activities of peptide leukotrienes (lt) on isolated spiral strips of ferret trachea were characterized pharmacologically. ltc4 and ltd4 contracted ferret tracheal strips in a concentration-related manner and were 3- to 8-fold more potent than carbachol. in contrast, high concentrations of lte4 evoked either weak contractions or none at all, whereas ltc4 and d4 were partial agonists compared to carbachol. in tissues which were unresponsive to lte4, this compound antagonized contra ... | 1986 | 3025931 |
| a permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret. | 1. the role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized ferret. 2. antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an intra-antral pressure of 0.27 +/- 0.11 kpa) by a vagal-dependent mechanism as indicated by the attenuated response seen during vagal blockade by cooling. atropine (1 mg/kg) abolished the antral response to distension. 3. in vagotomized ani ... | 1986 | 2887649 |
| relationship between force and intracellular [ca2+] in tetanized mammalian heart muscle. | to determine features of the steady state [ca2+]-tension relationship in intact heart, we measured steady force and intracellular [ca2+] ([ca2+]i) in tetanized ferret papillary muscles. [ca2+]i was estimated from the luminescence emitted by muscles that had been microinjected with aequorin, a ca2+-sensitive, bioluminescent protein. we found that by raising extracellular [ca2+] and/or by exposing muscles to the ca2+ channel agonist bay k 8644, tension development could be varied from rest to an a ... | 1986 | 2419483 |
| postnatal development of tracheal surface epithelium and submucosal glands in the ferret. | we explored the usefulness of the postnatal ferret as a model for early developmental events in the large airways, using light and scanning electron microscopy. in the first 28 postnatal days, ferret tracheal surface epithelium and glands undergo dramatic growth and development. tracheal surface area increases 8-fold. at birth, ciliated cells are sparse (9.4 +/- 1.2% of total epithelial cells). a significant increase in ciliated cells is observed at weekly intervals and by day 28 the ciliated ce ... | 1986 | 2420581 |
| morphology and histochemistry of the ferret prostate. | the gross anatomy, histology and histochemistry of the ferret prostate is described. the structure and course of the prostatic urethra and the ductus deferentes are also described. the prostate is the only accessory reproductive gland present in the ferret. the prostate consists of tubuloalveolar glands surrounded by fibromuscular connective tissue. histochemical studies showed that the glandular parenchyma contained large amounts of sialidase-labile sialomucin as well as acid phosphatase and sm ... | 1986 | 2422864 |
| camp immunocytochemistry provides evidence for functional vip receptors in trachea. | vasoactive intestinal peptide (vip), first isolated from porcine intestine (s. i. said and v. mutt, science wash. dc 169: 1217-1218, 1970), has been identified in postganglionic autonomic axons of many tissues. vip has potent regulatory effects on the function of various cell types within these tissues, ranging from relaxation of smooth muscle to ion transport. recently, vip has been implicated in the regulation of mucus secretion in the respiratory tract, a process involving release of macromol ... | 1986 | 2425626 |
| neuropeptides degranulate serous cells of ferret tracheal glands. | to determine whether serous or mucous cells in tracheal submucosal glands respond to the neuropeptides substance p (sp) and vasoactive intestinal peptide (vip), we studied the peptide-induced changes in gland cell morphology accompanying release of 35so4-labeled macromolecules from tracheal explants of ferrets. explants were labeled for 1 h in medium containing 35so4 and washed for 3.5 additional hours. base-line secretion in the absence of drugs declined between 1.5 and 3.5 h after the pulse. b ... | 1986 | 2426958 |
| biphasic contractions induced by milrinone at low temperature in ferret ventricular muscle: role of the sarcoplasmic reticulum and transmembrane calcium influx. | the effects of milrinone were studied in ferret papillary muscle stimulated at various rates and temperatures from 23 degrees to 36 degrees c. in voltage-clamp experiments, 50 micrograms/ml (0.237 mm) milrinone induced a 2.1-fold increase in calcium current at 28 degrees or 36 degrees c. at 50 micrograms/ml, milrinone transiently increased contractility in all muscles at 28 degrees c, but its steady-state effect was either increased (+50%) or decreased (-24.7%) steady-state twitch amplitude. a n ... | 1986 | 2427247 |
| sodium/calcium exchange and intracellular calcium buffering in ferret myocardium: an ion-sensitive micro-electrode study. | measurements of the intracellular activity of ca (aica), na (aina) and h (phi) ions have been made with resin-filled ion-sensitive micro-electrodes in ferret ventricular trabeculae. the mean values in quiescent muscle at 30 degrees c were: aina, 11.1 +/- 1.0 mm; aica, 58.4 +/- 6.4 nm, and phi, 7.20 +/- 0.11. the relation between aina and extracellular na activity (aona) is not linear and is sensitive to temperature: the q10 for the change in aina in normal tyrode solution is 1.3 +/- 0.5 and rise ... | 1986 | 2427694 |
| influence of the thyroid state on the calcium transient in ventricular muscle. | the purpose of this study was to determine the influence of thyroid hormone on tension development and the intracellular calcium transient in mammalian ventricular muscle. a hyperthyroid (h) state was induced in ferrets by subcutaneous injection of l-thyroxine, 0.3 mg/kg daily, for 2-3 weeks. one-half of the age matched control group (c) were injected with vehicle. aequorin was loaded into the cells of ferret papillary muscles by a chemical procedure. the muscles were stimulated at 0.33 hz and i ... | 1986 | 2428004 |
| maximal ca2+-activated force elicited by tetanization of ferret papillary muscle and whole heart: mechanism and characteristics of steady contractile activation in intact myocardium. | rapid (8-12 hz) stimulation of intact heart muscle treated with ryanodine results in steady contractile activation known as tetanus, the amplitude of which can be graded by changing extracellular ca2+ concentration ([ca2+]o). the mechanism of the sustained force generation was explored in ferret papillary muscles by measuring membrane potential and by determining the responsiveness of force and intracellular free ca2+ concentration ([ca2+]i, estimated with aequorin) to dihydropyridine ca channel ... | 1986 | 2429779 |
| mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal ca2+-activated force by inorganic phosphate. | we tested the hypothesis that accumulation of h+ or inorganic phosphate (pi) is responsible for the early contractile failure of hypoxia by measuring maximal ca2+-activated pressure and 31p nuclear magnetic resonance spectra in langendorff-perfused ferret hearts at 30 degrees c. maximal ca2+-activated pressure was identified by the saturation of pressure with respect to [ca2+]o observed during tetani as [ca2+]o was increased to 15 mm in hepes-buffered, 100% o2-bubbled perfusate and during hypoxi ... | 1986 | 2429780 |
| intracellular calcium transients underlying the short-term force-interval relationship in ferret ventricular myocardium. | the influence of short-term changes in stimulation pattern, both on the strength of contraction and on the amplitude of intracellular free-ca2+ transients, was investigated in ferret papillary muscles. intracellular free-ca2+ concentration ([ca2+]) was assessed from the luminescence emitted from muscles microinjected with the ca2+-sensitive photoprotein aequorin. the relationships between the strength of contraction and changes in stimulation pattern lasting 1-2 beats could be described by monoe ... | 1986 | 2432238 |
| sodium/calcium exchange and calcium buffering in mammalian ventricular muscle. | the na/ca exchange system was investigated in rapidly perfused small trabeculae (diameter around 250 micron) from ferret ventricle. in these preparations tension and em were recorded, aina, aik and aimg were measured using ion-selective microelectrodes. the mean aina at room temperature (22-24 degrees c) was 10.9 mmol/l +/- s.d. 4.2 mmol/l. when [na]o was reduced from 155 mmol/l to 1.5 mmol/l there was a rapid decrease in aina (half time 30 s), which was associated with a small increase in resti ... | 1986 | 2434687 |
| differential inotropic actions of ethmozine and ethacizin (diethylamine analog of ethmozine). | the direct inotropic actions of ethmozine and of its diethylamine analog, ethacizin, were studied in the presence of muscarinic and beta-adrenoreceptor blockade in 12 ferret right ventricular papillary muscles. in each muscle ethmozine caused a small but consistent and significant (p less than 0.05) increase in contractile performance, whereas ethacizin significantly (p less than 0.05) diminished contractility. although both phenothiazines are fast channel blockers, it appears that the net posit ... | 1986 | 2869671 |
| neural control of jejunal and ileal motility and transmural potential difference in the ferret. | the aim of the present study was to examine the vagal control of motor activity and transmural potential difference in the anaesthetized ferret jejunum and ileum in vivo. the data suggest that in the jejunum fluctuations in transmural potential difference occur secondary to spontaneous bursts of contractions and both are controlled by activity in the vagus nerve. however, in the ileum, spontaneous contractile activity and transmural potential difference are not under the tonic influence of the v ... | 1986 | 2870789 |
| regulation of salt and water transport across airway mucosa. | effective mucociliary clearance of secretions by airway mucosa requires efficient ciliary beating. the structure of airway secretions provides for this requirement by having a viscous mucous layer touched underneath and propelled by ciliary tips, while the rest of the cilium is surrounded by a serous fluid layer. the regulation of the latter layer is thought to be a function of mucosal epithelial cells capable of active ion transport. mammalian medium-sized bronchi actively absorb sodium, wherea ... | 1986 | 2872993 |
| the effects of amrinone and related drugs on intracellular calcium in isolated mammalian cardiac and vascular smooth muscle. | the effects of amrinone and related agents were studied in mammalian cardiac and vascular smooth muscle preparations loaded intracellularly with aequorin, a bioluminescent calcium indicator that emits light when it combines with ca++. in cat papillary muscles, the effects of amrinone on the amplitude and time course of the aequorin light signal, as they relate to changes in uptake and release of calcium from the sarcoplasmic reticulum and to changes in the sensitivity of the myofilaments to ca++ ... | 1986 | 3943182 |
| heterologous anti-progesterone monoclonal antibody arrests early embryonic development and implantation in the ferret (mustela putorius). | early embryo development and implantation were arrested in ferrets passively immunized with a mouse monoclonal anti-progesterone antibody injected intraperitoneally at 72 and 96 h post coitum (p.c.) or at 72 h p.c. only. in control ferrets injected with mouse serum or 0.9% nacl, implantation sites were found in all mated females; autopsies were carried out at day 14 p.c. a total of 34 unimplanted embryos were recovered from the reproductive tract of antibody-treated ferrets and none of these had ... | 1986 | 3944809 |
| is there a critical weight for oestrus in the ferret? | information concerning the weight at the onset of a period of oestrus, the timing of oestrus, the age at first oestrus and the lighting conditions was collected from the records of 1364 ferrets and reviewed for evidence indicating that the animals became sexually mature around a particular, critical, weight. none was found, but the results suggest that there is a minimum weight, around 420 g, below which oestrus does not occur. | 1986 | 3944810 |
| comparative studies of h3n2 influenza virus strains isolated in may-june, 1982, and in the subsequent epidemic in february, 1983: antigenic and genome analysis. | comparative studies have been undertaken on the h3n2 influenza virus strains isolated in leningrad in may-june, 1982 and those isolated in the subsequent winter epidemic in february, 1983. analysis of the isolates with ferret antisera against standard influenza viruses of the h3n2 subtype and with monoclonal antibodies against a/bangkok/1/79 virus revealed a considerable but similar degree of heterogeneity in the ha antigenic specificity of the strains isolated in the spring-summer, 1982, as in ... | 1986 | 3947238 |
| sexual dimorphism in the preoptic/anterior hypothalamic area of ferrets: effects of adult exposure to sex steroids. | the organization of neuronal cell bodies in the caudal preoptic area (poa) and rostral anterior hypothalamic area (ah) was studied in nissl-stained brain sections from adult male and female ferrets. computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes of individual perikarya. at the junction of the poa and ah, a bilateral dorsal-medial group of neurons was apparent only in male ferrets (dorsal nucleus). at the same coronal level, ... | 1986 | 3947970 |
| phase i study of ethylenediamine platinum(ii) malonate (nsc 146 068), a second generation platinum analogue. | ethylenediamine platinum(ii) malonate [jm-40 (nsc 146 068)] has been selected for clinical studies because of its favorable preclinical toxicity profile as a "second generation" platinum analogue. when compared to cisplatin, jm-40 was less emetic in the ferret and less nephrotoxic in the dog, while its antitumor activity approached that of cisplatin. twenty-nine patients received 86 courses of jm-40 as a single dose every 3-4 wk. after 13 dose escalation steps the maximum tolerable dose was reac ... | 1986 | 3948186 |
| severity of fever in influenza: differential pyrogenicity in ferrets exhibited by h1n1 and h3n2 strains of differing virulence. | intracardial inoculation of large quantities (200 micrograms viral protein/kg body weight) of infectious or u.v.-inactivated purified influenza viruses into ferrets resulted in a rapid febrile response which was significantly lower for two recently isolated h1n1 viruses, a/ussr/90/77 and a/fiji/15899/83, than for two virulent clones, 7a and 64c, of the a/puerto rico/8/34-a/england/939/69 (h3n2) reassortant virus system. these results, which are in accord with the severity of fever produced by th ... | 1986 | 3950579 |
| characterization of the mechanical behavior of isolated papillary muscle preparations of the ferret. | the characteristics of isometric and isotonic contraction were studied in isolated papillary muscle preparations from the right ventricle of the ferret and compared with those previously reported for comparable preparations from cat and rat. the effects of stimulation rate, temperature, extracellular calcium concentration, caffeine, verapamil, and ouabain were measured. afterloaded contractions and load clamps were used to study the mechanics of relaxation. the contractile characteristics of fer ... | 1986 | 3951236 |
| campylobacter-like organisms isolated from gastric mucosa of ferrets. | campylobacter-like organisms (clo) were isolated from gastric lesions in 1 ferret and gastric mucosa of 2 healthy ferrets. the organism was not isolated from biopsies of gastric mucosa of 14 other healthy ferrets, 1 of which had small gastric lesions located at the pylorus. lesions from which clo were isolated were located in the antrum of 1 ferret and were classified as inflammation with repair. affected gastric tissue was highly vascularized with fibrous connective tissue surrounding irregular ... | 1986 | 3954197 |
| focal hepatic necrosis in young ferrets infected with aeromonas species. | 1986 | 3959372 | |
| an electron microscope study of vagus nerve composition in the ferret. | the total number of axons in the cervical and abdominal vagus nerves of the ferret was counted. the ratio of myelinated to non-myelinated, and afferent to efferent axons was determined. the fibre diameter spectrum of myelinated axons was measured. the total number of axons in the ferret cervical vagus is similar to other mammals (approximately 28,000); the majority of axons are afferent (approx. 24,000) and also the majority of axons are nonmyelinated (approx. 27,000). the dorsal abdominal trunk ... | 1986 | 3826653 |
| intracisternal protein in the type ii pneumocyte of the ferret, guinea pig, and mongrel dog. | an intracisternal protein in the type ii pneumocyte of the ferret, guinea pig, and mongrel dog was examined by light and electron microscopy and morphometry. the basic pattern of layering in this membrane-bound, ribosome-studded structure (cisternal body) was visualized in cross section as dense layers separated by approximately 0.1 micron with seven fine layers between. in all species the central fine band of the seven was occasionally more prominent than the other six. in the guinea pig the se ... | 1986 | 3611844 |
| cell production gradients in the developing ferret isocortex. | the accumulation of cells within the cortical plate was studied in ferrets at two developmental ages. a survey method based on the presumed radial organisation of cortical neuron production was used to sample variations in cell production along the rostrocaudal and laterodorsal axes of the brain. the resulting cell counts confirmed the presence of a gradient of cortical plate formation, with a rostrolateral focus. these findings were discussed in relation to some recent teratological studies on ... | 1986 | 3693037 |
| gyrus formation in the cerebral cortex in the ferret. i. description of the external changes. | the external features of gyrus formation in the postnatal ferret cerebral cortex are described and correlated with certain internal changes. the observations indicate that gyri are formed by longitudinal and radial expansion of the cortical compartment occurring between relatively fixed areas which form the sulcal floors. the gyri were initially rounded with open sulci and the cerebrum had a rectangular outline when seen in lateral and dorsal view. by adult life the hemisphere had been subjected ... | 1986 | 3693054 |
| gyrus formation in the cerebral cortex of the ferret. ii. description of the internal histological changes. | the internal changes within a developing gyrus of the ferret cerebral cortex were studied by recording (i) the changing length and direction of the radial tissue lines and (ii) the emergence of the tangential banding of the classical six cortical layers. together these lines provided a coordinate net whose deformations during development gave an indication of the differential growth occurring within a gyrus. the changes in these features suggested that a gyrus was initiated by an area of local g ... | 1986 | 3693076 |
| patterns of blood supply to the gastric mucosa. a comparative study revealing an end-artery model. | the form of the gastric arterial supply to the mucosa has been studied in dog, swine, ferret, cat, guinea-pig, rabbit and rhesus monkey. in all these species, the bore of vessels in the submucous plexus diminished from body to pylorus, though this was most marked in the guinea-pig and rabbit. the plexus was also continuous across the pylorus with duodenal vessels. thus the well known poverty of vascularity in distal parts of the human stomach is shared by other species and is unlikely to be a co ... | 1986 | 3693108 |
| quantitation of the secretory cells of the ferret tracheobronchial tree. | the tracheal epithelium of the ferret has few goblet cells while sero-mucous submucosal glands are present in large numbers throughout the length of the trachea and bronchi. the epithelium consists mainly of ciliated cells and of dark cytoplasmic non-ciliated cells that sometimes contain secretory granules. any 'respiratory tract fluid' secreted into the ferret trachea is probably mainly glandular in origin. the epithelium contains neutrophils and a few mast cells and eosinophils. nerve fibres a ... | 1986 | 3429303 |
| assessment of techniques for preventing glycolysis in cardiac muscle. | studies of myocardial function during ischaemic or anoxia would be assisted if it were possible to inhibit glycolysis completely and reversibly. three methods of preventing glycolysis in isolated perfused ferret hearts were studied: (a) the removal of glucose from the perfusate followed by manoeuvres designed to deplete glycogen stores, (b) the use of 2-deoxyglucose, and (c) the use of iodoacetate. the rate of glycolysis before and after applying the three methods was assessed by measuring lacta ... | 1986 | 3621285 |
| transport of dimethylamine, a precursor of nitrosodimethylamine, into stomach of ferret and dog. | dimethylamine is important because it is a precursor of nitrosodimethylamine, a suspected carcinogen in man. significant quantities of dimethylamine and nitrite are found in gastric fluid, and conditions in the stomach are favorable for nitrosodimethylamine formation. little is known about the origins of dimethylamine in gastric fluid. studies were performed to determine whether dimethylamine can be transported from blood to gastric fluid. there was no diurnal variation of the dimethylamine cont ... | 1986 | 3698205 |
| the architecture of nerves and ganglia of the ferret trachea as revealed by acetylcholinesterase histochemistry. | the goal of this study was to determine the architecture of the nerves and ganglia of the ferret trachea. tracheas from four newborn ferrets and three adult ferrets were stained histochemically for acetylcholinesterase activity and analyzed in their entirety as whole mounts. the architecture consisted of one or two longitudinal nerve trunks overlying the posterior surface of the trachealis muscle, a dense plexus of nerves superficial to the trachealis muscle that interconnected these longitudina ... | 1986 | 3700726 |
| dirofilariasis in a ferret. | an adult male ferret was found to be lethargic and dyspneic. necropsy revealed 21 worms in the heart, vena cava, and pulmonary artery. the worms were identified as dirofilaria immitis. histologic examination of lung tissue revealed numerous microfilariae. | 1986 | 3710876 |
| age-related fiber order in the ferret's optic nerve and optic chiasm. | although the mammalian optic tract shows a grouping of fibers by age, with newer fibers nearer the pial surface, the possible rules for fiber ordering in the mammalian optic nerve have not been well defined. in this study, preferential labeling of the older retinal fibers in the ferret, a close relative of the cat, shows that the age-related fiber order in the ferret's optic tract reflects a systematic sorting of fibers by age that occurs in the optic nerve, and that is maintained through the op ... | 1986 | 3712001 |
| a comparison of two different indicators: quin 2 and aequorin in isolated single cells and intact strips of ferret portal vein. | a comparison between the fluorescent indicator quin 2 and the bioluminescent indicator aequorin was performed in the same smooth muscle cell type. aequorin was loaded into intact strips and quin was loaded into enzymatically isolated single cells from ferret portal vein. both indicators gave qualitatively the same calcium profiles when the tissue was challenged with agonists. quin loading caused a dramatic shift to the right in dose response curves to potassium and phenylephrine. the ed50 values ... | 1986 | 3714445 |
| changes in granule cells of the ferret olfactory bulb associated with imprinting on prey odours. | the maturation of the granule cells of the ferret olfactory bulb around the time of odour imprinting has been examined. rapid golgi impregnation studies revealed a temporal overshoot in the development of the spines on the external and internal dendrites of the granule cells. in contrast, the number of somatic spines decreased continuously. electron microscopical examinations of the synaptic contacts in the external plexiform layer revealed that the time course of synapse and reciprocal synapse ... | 1986 | 3719301 |
| evidence for a non-cholinergic excitatory innervation in the control of colonic motility. | the colon of the ferret anesthetized with urethane exhibits two distinct types of motility patterns. these were abolished or considerably reduced by blocking nervous conduction in the vagus nerves by cooling to below 4 degrees c. atropine transiently abolished motility which on its return was also found to be sensitive to vagal integrity. electrical stimulation of either the cut central or peripheral end of a branch of the abdominal vagus caused large amplitude contractions of the colon which we ... | 1986 | 3729625 |
| pulsatile release of luteinizing hormone and testosterone in male ferrets. | the temporal organization of lh and testosterone secretion was examined in male european ferrets. hormone levels were measured in frequent blood samples taken via an indwelling jugular cannula from sexually mature and castrated ferrets. intact ferrets discharge lh and testosterone in discrete pulses, but the frequency and amplitude of these pulses vary within and between individual males. the average frequency of lh pulses was 1.14 +/- 0.25 pulses/h, with an amplitude of 1.59 +/- 0.23 ng/ml in 1 ... | 1986 | 3732162 |
| k+-induced alterations in airway muscle responsiveness to electrical field stimulation. | we investigated possible pre- and postsynaptic effects of k+-induced depolarization on ferret tracheal smooth muscle (tsm) responsiveness to cholinergic stimulation. to assess electromechanical activity, cell membrane potential (em) and tension (tm) were simultaneously recorded in buffer containing 6, 12, 18, or 24 mm k+ before and after electrical field stimulation (efs) or exogenous acetylcholine (ach). in 6 mm k+, em was -58.1 +/- 1.0 mv (mean +/- se). in 12 mm k+, em was depolarized to -52.3 ... | 1986 | 3733628 |
| sexual differentiation of play behavior in the ferret. | three experiments were performed to elucidate the endocrine mechanisms responsible for sex differences in the prepubertal play behavior of ferrets. in experiment 1, gonadally intact adolescent males exhibited higher levels of "stand-over" behavior than females did in tests between 63 and 123 days of age with gonadally intact female partners of the same age. in experiment 2, ferrets exposed to androgen or to ovarian steroids over days 5-20 of postnatal life subsequently exhibited significantly hi ... | 1986 | 3741607 |
| annual rhythm and hormonal control of predatory behavior in female ferrets. | the predatory behavior of female ferrets shows seasonal fluctuations which appear to be affected by estradiol. under natural lighting conditions in the laboratory the annual rhythm of the behavior was observed during anestrus, estrus, pregnancy, pseudopregnancy and lactating period. females in heat failed to show predatory behavior whereas females in anestrus killed their prey. exposure of anestrous ferrets to a prolonged illumination (ld 16:8) during winter induced an estrus which inhibited pre ... | 1986 | 3749320 |
| neonatal exposure of female ferrets to testosterone alters sociosexual preferences in adulthood. | sociosexual preferences in adult female ferrets, as measured in a choice arena, were altered by neonatal exposure to exogenous testosterone. adult female ferrets showed a preference for males which did not depend on the presence of gonadal steroids, because gonadectomized and gonadectomized estrogen-treated females showed identical preferences for males. adult castrated males showed no preference for females unless these males were treated with testosterone. a similar no-preference pattern was f ... | 1986 | 3749401 |
| antibody and cellular immune responses to microfilarial antigens in ferrets experimentally infected with brugia malayi. | eleven of 15 ferrets experimentally infected with brugia malayi became amicrofilaremic after a brief patency; only four ferrets remained patent after 6 months of infection and two of these ferrets developed a high, persistent microfilaremia. blastogenic responses of peripheral blood lymphocytes to antigens of microfilariae (mf), assayed in vitro, demonstrated an antigen sensitivity at prepatent, patent and postpatent periods of infection. lymphocytes from ferrets with high microfilaremia had ele ... | 1986 | 3751232 |
| cold-adapted reassortants of influenza a virus: pathogenicity of a/ann arbor/6/60 x a/alaska/6/77 reassortant viruses in vivo and in vitro. | cold-adapted reassortants of a/ann arbor/6/60 x a/alaska/6/77 viruses made in mdck cells have recently been assessed genotypically and for temperature-sensitive and cold-adapted phenotypes. these reassortants were used to infect ferrets and hamsters and to inoculate organ cultures of hamster tracheal rings, in order to assess their degree of virulence. virulence in the three model systems corresponded quite well, and a correlation between loss of virulence and particular a/aa/6/60 genes present ... | 1986 | 3753204 |
| ion transport across cat and ferret tracheal epithelia. | sheets of trachea from ferret and cat were mounted in ussing chambers and continuously short circuited. under resting conditions, in both the cat and ferret there was little or no cl secretion, and na absorption accounted for most of the short-circuit current (isc). ouabain (10(-4) m, serosal bath) reduced isc to zero in 30-60 min. this decline was matched by a decrease in net na absorption. amiloride (10(-4) m, luminal bath) caused a significant decrease in isc and conductance (g) in both speci ... | 1986 | 3759745 |
| the direct negative inotropic effect of gossypol. | gossypol, an effective male antifertility agent, had a minor but significant negative inotropic action in isolated ferret right ventricular papillary muscles at concentrations of 1-5 micrograms/ml. reduction of peak developed force and maximum extent of shortening was readily demonstrable at three different resting control contractile states achieved through increases in extracellular calcium from 0.625 to 2.5 mm/l. gossypol had no significant effect on maximum rate of tension rise nor on maximu ... | 1986 | 3762194 |
| internal potassium activity in ferret ventricular muscle. | measurements of the k activity (aik) in ferret ventricle were made using either single- or double-barrelled k-sensitive micro-electrodes. aik was also estimated from the nernst equation by measuring the membrane potential when changing the external k concentration. micro-electrodes filled with the corning k sensor gave unreliable results most probably due to interference from some substance(s) in the heart cells. reproduceable measurements were obtained using a valinomycin cocktail as the k sens ... | 1986 | 3763807 |
| free intracellular magnesium concentration in ferret ventricular muscle measured with ion selective micro-electrodes. | the free mg concentration ([mg]i) was measured in ferret ventricular muscle using single-barrelled mg-sensitive micro-electrodes. the electrodes were calibrated in solutions containing the [k]i and [na]i measured in this tissue. in thirteen measurements from seven experiments conforming to strict criteria for calibration and penetration the estimated mean [mg]i was 0.4 mmol/l. this is to be regarded as an upper limit since it was estimated by linear extrapolation of the calibration curve. | 1986 | 3763808 |
| molecular studies of the differential replication at pyrexial temperatures of two influenza viruses differing in virulence for ferrets. | replication of a virulent clone (7a) of the reassortant influenza virus a/puerto rico/8/34-a/england/939/69 (h3n2) in ferret nasal turbinate tissue is less affected than that of an attenuated clone (64d) by temperatures which occur during pyrexia in ferrets. this is a factor which contributes to the difference in virulence of the two clones. the differential replication of the two clones at pyrexial temperatures has been reproduced in allantois-on-shell (egg-bit) cultures, and the synthesis of v ... | 1986 | 3765825 |
| representation of the cochlea in primary auditory cortex of the ferret (mustela putorius). | in seven barbiturate-anesthetized ferrets, we explored the acoustically sensitive cortex with conventional microelectrode mapping techniques. a tonotopically organized field was found whose orientation was such that high tonal frequencies were represented dorsally, and low frequencies ventrally. within this field, neurons typically had short (12-20 ms) latent periods to first spikes. in conjunction with extant anatomical evidence on the connectivity of this region, these data suggest that this f ... | 1986 | 3771373 |
| mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. | drug-induced triggered arrhythmias in heart muscle involve oscillations of membrane potential known as delayed or early afterdepolarizations (dads or eads). we examined the mechanism of dads and eads in ferret ventricular muscle. membrane potential, tension and aequorin luminescence were measured during exposure to elevated [ca2+]0, strophanthidin and/or isoproterenol (to induce dads), or cesium chloride (to induce eads). ryanodine (10(-9)-10(-6) m), an inhibitor of ca2+ release from the sarcopl ... | 1986 | 3771791 |
| virus contamination and cytopathology of ferret tracheal epithelial cells in culture caused by vaccination with distemper virus. | 1986 | 3773467 | |
| 5-hydroxytryptamine m-receptor antagonism to prevent cisplatin-induced emesis. | the administration to the ferret of cisplatin, 10mg/kg (i.v.), caused an intense emetic response that was prevented by ics 205-930 (0.1 and 1.0 mg/kg i.v.) and metoclopramide (4.0 mg/kg i.v.). smaller doses of ics 205-930 (0.01 mg/kg i.v.) and metoclopramide (2.0 mg/kg i.v.) attenuated the emetic response to cisplatin. it is concluded that the potent action of ics 205-930 against cisplatin-induced emesis is the consequence of a 5-hydroxytryptamine m-receptor antagonism which may also contribute ... | 1986 | 3774121 |
| the effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. | by examination of compound action potentials in the saphenous nerve of the anaesthetized rat it has been shown that capsaicin causes a rapid, dose-dependent, failure of conduction in many c-fibres when applied directly to the nerve. a large reduction in c-fibre conduction occurs with concentrations as low as 110 microm. after a 15-30 min exposure to capsaicin, only partial recovery occurs in 1 h. similar block of c-fibre conduction occurs in the ferret. however, only smaller, reversible, reducti ... | 1986 | 3779210 |
| basal n-nitrosoproline formation and excretion in the ferret. | quantitative balance studies indicated that ferrets (mustela putorius furo) on purified diets excreted approximately four times more n-nitrosoproline than they ingested. this basal n-nitrosoproline excretion was not dependent on dietary nitrate intake, as high levels of dietary [15n]nitrate did not result in the incorporation of 15n into the excreted n-nitrosoproline. this indicates that there are at least two sources of endogenous n-nitrosoproline formation, one linked to dietary nitrate and on ... | 1986 | 3781434 |
| concealed positive force-frequency relationships in rat and mouse cardiac muscle revealed by ryanodine. | increases in stimulation frequency between 0.3 and 2 hz decrease developed tension in rat, seemingly inconsistent with the explanation that an elevation of intracellular na+-ion concentration is responsible for the positive force-frequency relationships observed in most species. thus the force-frequency relationships were reevaluated in isolated atrial muscle of rat and mouse heart that show negative relationships, comparing them with ferret and guinea pig that show positive relationships. ryano ... | 1986 | 3789163 |
| hearing in the ferret (mustela putorius): thresholds for pure tone detection. | thresholds for pure tone detection were determined for two male ferrets (mustela putorius) using standard behavioral testing procedures. both animals had a broad range of hearing comparable to that seen in other carnivores. the lower limit of hearing at 60 db spl was estimated from the average audiogram to be 36 hz, and the upper limit of hearing was 44 khz. the lowest thresholds were found in the region of 8-12 khz with both animals exhibiting sharp tuning at best frequency. | 1986 | 3793642 |
| use of indirect and competitive elisas to compare isolates of equine influenza a virus. | antigenic differences within equine-1 and equine-2 isolates of influenza were studied by haemagglutination inhibition tests, indirect elisa and competition elisa, using the same antisera. better differentiation was obtained with the competition elisa than with the other two tests. all three methods produced similar relationships within the equine-1 isolates but differed in their ability to differentiate the equine-2 isolates where the competition elisa was superior and produced epidemiologically ... | 1986 | 3793836 |
| morphological features of spiking and nonspiking cells in the paratracheal ganglion of the ferret. | the present series of experiments was designed to study details of the morphology and connectivity of functionally identified cells located in the paratracheal ganglia of the ferret. the morphology of 11 spiking (ah cells) and seven nonspiking (type b cells) ganglion cells was examined. intra-axonally injected horseradish peroxidase (hrp) was used as the label. each spiking and nonspiking cell was identified by intracellular recording prior to the hrp injection. "whole mount preparations" were p ... | 1986 | 3794010 |
| metabolic consequences of increasing intracellular calcium and force production in perfused ferret hearts. | 31p nuclear magnetic resonance was used to measure the relative concentrations of phosphorus-containing metabolites in langendorff-perfused ferret hearts. intracellular concentrations of inorganic phosphate ([pi]i), phosphocreatine [( pcr]i), atp ([atp]i) and [h+] (phi) were determined. exposure of the heart to strophanthidin (10-40 microm) produced an increase in developed pressure over 5-10 min. in the presence of strophanthidin, [atp]i was unchanged, [pcr]i showed a small fall, [pi]i showed a ... | 1986 | 3795073 |
| proliferative colitis in a pet ferret. | a 4-month-old male ferret was examined because of mucus-laden diarrhea of several days' duration. the diarrhea became bloody and the ferret became progressively anorexic and lost weight. treatment with antibiotics did not result in amelioration of clinical signs. a biopsy specimen was obtained from the colon, which was thick and turgid. proliferative colitis associated with campylobacter sp infection was diagnosed histologically. because of the poor prognosis and potential zoonotic hazard associ ... | 1986 | 3804844 |
| measurement and control of intracellular magnesium ion concentration in guinea pig and ferret ventricular myocardium. | intracellular magnesium and sodium ionic concentrations have been measured in mammalian ventricular myocardium using ion-selective micro-electrodes. the values for [na+]i and [mg2+]i are 9.5 +/- 0.3 and 2.4 +/- 0.2 mm, respectively. increasing extracellular [mg] or decreasing extracellular [na] both caused a rise of [mg2+]i and a fall of [na+]i. superfusion with ouabain caused a small rise of [mg2+]i as well as a rise of [na+]i. reduction of extracellular [mg] or cell depolarisation had no effec ... | 1986 | 3807424 |
| differentiation in male ferrets of a sexually dimorphic nucleus of the preoptic/anterior hypothalamic area requires prenatal estrogen. | experiments were conducted to determine when during perinatal development testicular steroids act in ferrets to promote the organization of a bilateral nucleus in a medial position at the border of the preoptic area (poa) and anterior hypothalamus (ah), henceforth referred to as the male nucleus of the poa/ah (mn-poa/ah). the formation of the mn-poa/ah was promoted in female offspring by treating their mothers with testosterone over the last 11 days of the 42-day gestation period, whereas mn-poa ... | 1986 | 3808217 |
| a congenital toxoplasma-like disease in ferrets (mustela putorius furo). | approximately 30% of 750 neonatal farmed ferret kits died without observed clinical signs. the presence of multifocal necrosis associated with toxoplasma-like organisms in the liver, lung and heart suggested a diagnosis of toxoplasmosis. surviving animals from affected litters were stunted but showed no histological or serological evidence of toxoplasma infection, nor could infection be demonstrated by mouse inoculation. the involvement of animals at one day of age indicated congenitally acquire ... | 1986 | 16031250 |
| suspected foreign body peritonitis in fitch (mustela putorius furo). | a severe, fatal, exudative peritonitis was investigated in a flock of 100 breeding fitch mustela putorius furo. the presence of enteric flora within the lesions and steel spicules within the stomach contents suggested that this disease may have been caused by steel fragments perforating the intestine. scoring and pitting of a steel mincer plate used for food preparation consistent with the size and shape of the steel particles found in the stomach, further supported this hypothesis. there were n ... | 1986 | 16031296 |
| antibodies to the n-terminus of human gastrin-34 react with material in rat and ferret brain. | antibodies specific for the n-terminus of human big gastrin, or nt g34, reveal in immunohistochemistry extensive systems of nerve cell bodies and fibres in the rat and ferret brain. however, when the same antibodies were used in radioimmunoassay of rat and ferret brain tissue extracts they failed to reveal immunoreactive material. at least one of the antibodies used for radioimmunoassay could be shown to react with nt g34 in rat pyloric antral extracts. antibodies specific for other peptides der ... | 1986 | 20493085 |
| inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine m-receptor antagonism. | mdl 72222, the selective 5-hydroxytryptamine (5-ht) m-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. it is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-ht m-receptor mechanism. | 1986 | 3742146 |
| ferrets as pets. | 1986 | 3721957 | |
| effect of arginine-free diet on ammonia metabolism in young and adult ferrets. | two-month-old, male ferrets were fasted for 16 h and fed a synthetic, arginine-free diet. within 2-3 h after ingesting the diet, they developed hyperammonemia and encephalopathy. ammonia levels in the serum, brain and cerebrospinal fluid were greatly elevated compared to those of ferrets fed the synthetic diet supplemented with arginine. orotic acid and glucose levels in serum were also significantly elevated. urinary orotic acid was significantly increased but citrate and creatinine level were ... | 1986 | 3958802 |
| [heat perils in ferrets]. | 1986 | 3952723 |