Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| high prevalence and genetic diversity of plasmodium malariae and no evidence of plasmodium knowlesi in bangladesh. | although the prevalence of malaria remains high in parts of bangladesh, there continues to be a substantial shortage of information regarding the less common malaria parasites such as plasmodium malariae or plasmodium knowlesi. recent studies indicate that p. malariae may be extremely rare, and so far, there are no data on the presence (or absence) of p. knowlesi in southeastern bangladesh. genus- and species-specific nested polymerase chain reaction (pcr) analysis of the small subunit ribosomal ... | 2014 | 24578257 |
| evaluation of three rapid diagnostic tests for the detection of human infections with plasmodium knowlesi. | plasmodium knowlesi, a malaria parasite of southeast asian macaques, infects humans and can cause fatal malaria. it is difficult to diagnose by microscopy because of morphological similarity to plasmodium malariae. nested pcr assay is the most accurate method to distinguish p. knowlesi from other plasmodium species but is not cost effective in resource-poor settings. rapid diagnostic tests (rdts) are recommended for settings where malaria is prevalent. in this study, the effectiveness of three r ... | 2014 | 24548805 |
| in vivo imaging in nhp models of malaria: challenges, progress and outlooks. | animal models of malaria, mainly mice, have made a large contribution to our knowledge of host-pathogen interactions and immune responses, and to drug and vaccine design. non-human primate (nhp) models for malaria are admittedly under-used, although they are probably closer models than mice for human malaria; in particular, nhp models allow the use of human pathogens (plasmodium falciparum, plasmodium vivax, plasmodium malariae and plasmodium knowlesi). nhps, whether natural hosts or experimenta ... | 2014 | 24042056 |
| glomerulonephropathies in plasmodium inui-infected rhesus monkey: a primate model and possible applications for human quartan malaria. | summary none of the few animal models proposed for the study of human quartan malaria nephritic syndrome have shown complete pathological findings that are similar to those seen in humans. this study investigated the histopathological changes in kidneys in 10 plasmodium inui infected macaca mulatta monkeys by light and electron microscopy in order to develop a suitable animal model for human quartan malaria. ten healthy adult rhesus monkeys were infected with p. inui and clinical chemistry and h ... | 2014 | 25023338 |
| [one transfusion-transmitted plasmodium malariae infection case in shanghai]. | 2014 | 25902679 | |
| a nephrotic syndrome of tropical origin: case report and short review of the aetiology. | we present a case of nephrotic syndrome in a 38-year-old man of ivorian origin. in the search of the cause of his illness an infection with plasmodium malariae (p. malariae) was diagnosed by serology and by microscopy of a giemsa thin blood smear which revealed rare gametocytes of p. malariae. proteinuria significantly diminished within three months after antimalarial treatment. antibodies against schistosoma were detected as well. examination of kidney biopsy revealed a discrete mesangioprolife ... | 2014 | 25103593 |
| [two cases of african imported plasmodium malariae malaria]. | the process of diagnosis, epidemiological survey and treatment of two cases of african imported quartan malaria is reported in this paper. | 2014 | 25051852 |
| plasmodium malariae infection: a case of missed diagnosis. | 2014 | 24947226 | |
| [diagnosis and treatment for three imported plasmodium malariae malaria cases in henan province]. | giemsa-stained blood film microscopy, carestart rapid detection and pcr were used to detect the three cases who returned from angola and equatorial guinea to henan province. onset of malaria symptoms for two patients occurred 15 d and 27 d after their return from angola, respectively. two months after returning home, another case relapsed who had suffered from malaria in equatorial guinea. all three patients had the symptoms such as irregular fever, headache, chills and so on. two cases had elev ... | 2014 | 24822369 |
| recrudescence of plasmodium malariae after quinine. | plasmodium malariae causes uncommon benign malaria found in the malaria endemic regions mostly of sub-saharan africa. as plasmodium malariae does not have a continued liver stage in humans the only way to have reinfection without reexposure is through recrudescence. however, reports of its recrudescence after antimalarials are rare with only a handful of case reports in the literature. research in this field to date has not been able to establish definitively an emergence of resistance in plasmo ... | 2014 | 24711818 |
| genetic variability of plasmodium malariae dihydropteroate synthase (dhps) in four asian countries. | the dihydropteroate synthase (dhps) genes of 44 p. malariae strains from four asian countries were isolated. only a limited number of polymorphisms were observed. comparison with homologous mutations in other plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance. | 2014 | 24699454 |
| the challenges of caring for children with nephrotic syndrome in a tertiary institution in the democratic republic of congo. | the care of children with resistant nephrotic syndrome (ns) in the democratic republic of congo is compromised by resource deficiencies that range from inadequate healthcare budgets, to scarce laboratory facilities and inconsistent drug supplies. the aim of this study was to describe the clinical profile and management of children with nephrotic syndrome in kinshasa, the country's capital and its largest city. | 2014 | 24673208 |
| a morphology-based method for the diagnosis of red blood cells parasitized by plasmodium malariae and plasmodium ovale. | the morphology of red blood cells (rbcs) is altered significantly during the maturation stages of malaria parasites, which include ring, trophozoite, and schizont. there is dissimilarity in terms of the morphological characteristics of parasitized rbcs infected by the 4 species of plasmodium, including falciparum, vivax, malariae, and ovale. this makes the process of diagnosis very difficult, which may lead to a wrong treatment method and substantial damage to the health of the patient. an innov ... | 2014 | 24568595 |
| a 20-year longitudinal study of plasmodium ovale and plasmodium malariae prevalence and morbidity in a west african population. | plasmodium ovale and plasmodium malariae have long been reported to be widely distributed in tropical africa and in other major malaria-endemic areas of the world. however, little is known about the burden caused by these two malaria species. | 2014 | 24520325 |
| sequence-based optimization of a quantitative real-time pcr assay for detection of plasmodium ovale and plasmodium malariae. | although microscopic examination of giemsa-stained blood smears remains the gold standard for the diagnosis of malaria, molecular detection using pcr is becoming increasingly popular. due to discrepant pcr and microscopy results, we aimed to optimize our detection assays for plasmodium malariae and plasmodium ovale by sequencing the 18s rrna region and developing a new primer and probe set for real-time quantitative pcr (qpcr). clinical specimens positive for p. malariae (n = 15) or p. ovale (n ... | 2014 | 24430459 |
| detection of intracellular parasites by use of the cellavision dm96 analyzer during routine screening of peripheral blood smears. | conventional microscopy is the gold standard for malaria diagnosis. the cellavision dm96 is a digital hematology analyzer that utilizes neural networks to locate, digitize, and preclassify leukocytes and characterize red blood cell morphology. this study compared the detection rates of plasmodium and babesia species on peripheral blood smears utilizing the cellavision dm96 with the rates for a routine red blood cell morphology scan. a total of 281 slides were analyzed, consisting of 130 slides p ... | 2015 | 25378575 |
| [laboratory analysis and diagnosis of one transfusion-transmitted quartan malaria case in shanghai city]. | to diagnose a case of quartan malaria with unknown origin by laboratory detection. | 2015 | 26767256 |
| plasmodium malariae infection associated with a high burden of anemia: a hospital-based surveillance study. | plasmodium malariae is a slow-growing parasite with a wide geographic distribution. although generally regarded as a benign cause of malaria, it has been associated with nephrotic syndrome, particularly in young children, and can persist in the host for years. morbidity associated with p. malariae infection has received relatively little attention, and the risk of p. malariae-associated nephrotic syndrome is unknown. | 2015 | 26720002 |
| plasmodium malariae malaria: from monkey to man? | 2015 | 26501096 | |
| delayed onset of symptoms and atovaquone-proguanil chemoprophylaxis breakthrough by plasmodium malariae in the absence of mutation at codon 268 of pmcytb. | plasmodium malariae is widely distributed across the tropics, causing symptomatic malaria in humans with a 72-hour fever periodicity, and may present after latency periods lasting up to many decades. delayed occurrence of symptoms is observed in humans using chemoprophylaxis, or patients having received therapies targeting p. falciparum intraerythrocytic asexual stages, but few investigators have addressed the biological basis of the ability of p. malariae to persist in the human host. to invest ... | 2015 | 26485258 |
| plasmodium knowlesi malaria during pregnancy. | plasmodium knowlesi is the commonest cause of malaria in malaysia, but little is known regarding infection during pregnancy. | 2015 | 25301955 |
| malaria in a tertiary hospital in singapore--clinical presentation, treatment and outcome: an eleven year retrospective review. | malaria remains a global health threat and poses significant health risks even in non-endemic regions like singapore. | 2015 | 25467088 |
| mass screening and treatment on the basis of results of a plasmodium falciparum-specific rapid diagnostic test did not reduce malaria incidence in zanzibar. | seasonal increases in malaria continue in hot spots in zanzibar. mass screening and treatment (msat) may help reduce the reservoir of infection; however, it is unclear whether rapid diagnostic tests (rdts) detect a sufficient proportion of low-density infections to influence subsequent transmission. | 2015 | 25429102 |
| severe malarial thrombocytopenia: a risk factor for mortality in papua, indonesia. | the significance of thrombocytopenia to the morbidity and mortality of malaria is poorly defined. we compared the platelet counts and clinical correlates of patients with and those without malaria in southern papua, indonesia. | 2015 | 25170106 |
| malaria case in madagascar, probable implication of a new vector, anopheles coustani. | indoor spraying of insecticides and the use of insecticide-treated bed nets are key strategies for national malaria vector control in the central highlands of madagascar. during the year 2013, malaria outbreaks were reported by the national malaria control programme in the highlands, including the district of ankazobe. | 2015 | 26620552 |
| plasmodium falciparum in the southeastern atlantic forest: a challenge to the bromeliad-malaria paradigm? | recently an unexpectedly high prevalence of plasmodium falciparum was found in asymptomatic blood donors living in the southeastern brazilian atlantic forest. the bromeliad-malaria paradigm assumes that transmission of plasmodium vivax and plasmodium malariae involves species of the subgenus kerteszia of anopheles and only a few cases of p. vivax malaria are reported annually in this region. the expectations of this paradigm are a low prevalence of p. vivax and a null prevalence of p. falciparum ... | 2015 | 25909655 |
| molecular investigation of mixed malaria infections in southwest saudi arabia. | to investigate the incidence of mixed-species (ms) malaria infection, and compare the results with microscopically confirmed cases of malaria. | 2015 | 25719595 |
| molecular detection of human plasmodium species in sabah using plasmonex™ multiplex pcr and hydrolysis probes real-time pcr. | malaria is a vector borne-parasitic disease transmitted through the bite of the infective female anopheles mosquitoes. five plasmodium species have been recognized by world health organization (who) as the causative agents of human malaria. generally, microscopic examination is the gold standard for routine malaria diagnosis. however, molecular pcr assays in many cases have shown improvement on the sensitivity and specificity over microscopic or other immunochromatographic assays. | 2015 | 25651852 |
| malaria parasitemia in apparently healthy blood donors in north-central nigeria. | to determine the prevalence of transmissible malaria in apparently healthy blood donors in the city of jos in north-central nigeria. | 2015 | 25617391 |
| a molecular survey of acute febrile illnesses reveals plasmodium vivax infections in kedougou, southeastern senegal. | control efforts towards malaria due to plasmodium falciparum significantly decreased the incidence of the disease in many endemic countries including senegal. surprisingly, in kedougou (southeastern senegal) p. falciparum malaria remains highly prevalent and the relative contribution of other plasmodium species to the global malaria burden is very poorly documented, partly due to the low sensitivity of routine diagnostic tools. molecular methods offer better estimate of circulating plasmodium sp ... | 2015 | 26186936 |
| the epidemiology of imported malaria and transfusion policy in 5 nonendemic countries. | addressing risk of imported malaria is complicated by 5 human species of plasmodium, semi-immunity in donors with long-term exposure, increasing travel and immigration, changing risk in endemic areas, and limitations of screening assays. to gain insight into policy formulation, we have compiled epidemiologic data from 5 countries with different policies involving either deferral (the united states and canada) or selective testing (france, england, and australia). the greatest risk is from semi-i ... | 2015 | 25933591 |
| a retrospective study on imported malaria in jordan. 2. malaria among non-military jordanians. | cases of imported malaria among civilian jordanians returning from asian and african countries from 1991-2011 are documented. a total of 511 cases of imported malaria were diagnosed among civilian jordanians travelling abroad. majority of cases were reported among adults over 21 year old accounting for or 87,67% of the total number of cases. eighteen different categories of occupation were identified, where as students studying abroad showed the highest infection rate (33.2%), especially those r ... | 2015 | 25925812 |
| the relationship between plasmodium infection, anaemia and nutritional status in asymptomatic children aged under five years living in stable transmission zones in kinshasa, democratic republic of congo. | malaria is preventable and treatable when recommended interventions are properly implemented. thus, diagnosis and treatment focus on symptomatic individuals while asymptomatic plasmodium infection (pi) plays a role in the sustainability of the transmission and may also have an impact on the morbidity of the disease in terms of anaemia, nutritional status and even cognitive development of children. the objective of this study was to assess pi prevalence and its relationship with known morbidity f ... | 2015 | 25880427 |
| contribution of polymerase chain reaction for detection of malaria in tunisia. | in tunisia, detection of plasmodium in asymptomatic individuals from endemic countries is a critical measure in national program of malaria eradication. the screening is based on microscopic examination of thick and thin blood smears. however, the performance of this diagnosis is closely related to the experience of biologist and the parasitaemia. | 2015 | 27249386 |
| merozoite surface protein-1 genetic diversity in plasmodium malariae and plasmodium brasilianum from brazil. | the merozoite surface protein 1 (msp1) gene encodes the major surface antigen of invasive forms of the plasmodium erythrocytic stages and is considered a candidate vaccine antigen against malaria. due to its polymorphisms, msp1 is also useful for strain discrimination and consists of a good genetic marker. sequence diversity in msp1 has been analyzed in field isolates of three human parasites: p. falciparum, p. vivax, and p. ovale. however, the extent of variation in another human parasite, p. m ... | 2015 | 26572971 |
| natural infection of plasmodium brasilianum in humans: man and monkey share quartan malaria parasites in the venezuelan amazon. | the quartan malaria parasite plasmodium malariae is the widest spread and best adapted human malaria parasite. the simian plasmodium brasilianum causes quartan fever in new world monkeys and resembles p. malariae morphologically. since the genetics of the two parasites are nearly identical, differing only in a range of mutations expected within a species, it has long been speculated that the two are the same. however, no naturally acquired infection with parasites termed as p. brasilianum has be ... | 2015 | 26501116 |
| simian malaria in the brazilian atlantic forest: first description of natural infection of capuchin monkeys (cebinae subfamily) by plasmodium simium. | in brazil, two species of plasmodium have been described infecting non-human primates, plasmodium brasilianum and plasmodium simium. these species are morphologically, genetically and immunologically indistinguishable from the human plasmodium malariae and plasmodium vivax parasites, respectively. plasmodium simium has been observed naturally infecting monkeys of the genera alouatta and brachyteles in a restricted area of the atlantic forest in the south and southeast regions of brazil. however, ... | 2015 | 25889933 |
| comparison of a pfhrp2-based rapid diagnostic test and pcr for malaria in a low prevalence setting in rural southern zambia: implications for elimination. | rapid diagnostic tests (rdts) detecting histidine-rich protein 2 (pfhrp2) antigen are used to identify individuals with plasmodium falciparum infection even in low transmission settings seeking to achieve elimination. however, these rdts lack sensitivity to detect low-density infections, produce false negatives for p. falciparum strains lacking pfhrp2 gene and do not detect species other than p. falciparum. | 2015 | 25888818 |
| analysis of antibody profiles in symptomatic malaria in three sentinel sites of ivory coast by using multiplex, fluorescent, magnetic, bead-based serological assay (magpix™). | advances in malaria control have reduced the burden of disease resulting from exposure to parasite infections. the consequences on naturally acquired immunity are unclear. a magnetic bead-based immunoassay (mba) to assess antibody levels in populations living in endemic areas was previously evaluated. in this study, the effect of clinical attacks on immunity was analysed in three sentinel sites of ivory coast. | 2015 | 26692284 |
| plasmodium vivax infection: a major determinant of severe anaemia in infancy. | most malarious countries outside of africa are co-endemic for plasmodium falciparum and plasmodium vivax. the comparative burden of anaemia in the community caused by these two species is incompletely characterized. | 2016 | 27306221 |
| the increasing importance of plasmodium ovale and plasmodium malariae in a malaria elimination setting: an observational study of imported cases in jiangsu province, china, 2011-2014. | following initiation of china's national malaria elimination action plan in 2010, indigenous malaria infections in jiangsu province decreased significantly. meanwhile imported plasmodium infections have increased substantially, particularly plasmodium ovale and plasmodium malariae. given the risk for malaria resurgence, there is an urgent need to understand the increase in imported p. ovale and p. malariae infections as china works to achieve national malaria elimination. | 2016 | 27604629 |
| characteristics of imported malaria and species of plasmodium involved in shandong province, china (2012-2014). | malaria remains a serious public health problem in shandong province, china; therefore, it is important to explore the characteristics of the current malaria prevalence situation in the province. in this study, data of malaria cases reported in shandong during 2012-2014 were analyzed, and plasmodium species were confirmed by smear microscopy and nested-pcr. a total of 374 malaria cases were reported, 80.8% of which were reported from 6 prefectures. of all cases, p. falciparum was dominant (81.3% ... | 2016 | 27658591 |
| malaria in children of tshimbulu (western kasai, democratic republic of the congo): epidemiological data and accuracy of diagnostic assays applied in a limited resource setting. | the literature data on malaria in western kasai, drc, are limited and inadequate. a recent molecular survey there has detected plasmodium ovale and plasmodium malariae as mixed infections with plasmodium falciparum. in tshimbulu, western kasai, during a humanitarian initiative designed to provide children with free preventive screening and to reduce the local high malaria death rate, accurate species identification was performed, in order to collect unambiguous epidemiological data and to evalua ... | 2016 | 26864461 |
| high plasmodium malariae prevalence in an endemic area of the colombian amazon region. | malaria is a worldwide public health problem; parasites from the genus plasmodium are the aetiological agent for this disease. the parasites are mostly diagnosed by conventional microscopy-based techniques; however, their limitations have led to under-registering the reported prevalence of plasmodium species. this study has thus been aimed at evaluating the infection and coinfection prevalence of 3 species of plasmodium spp., in an area of the colombian amazon region. blood samples were taken fr ... | 2016 | 27467587 |
| widespread distribution of plasmodium vivax malaria in mauritania on the interface of the maghreb and west africa. | plasmodium vivax is very rarely seen in west africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from north africa. however, this parasite species has recently been reported to account for most malaria cases in nouakchott, the capital of mauritania, which is a large country at the interface of sub-saharan west africa and the maghreb region in northwest africa. | 2016 | 26861780 |
| plasmodium malariae in the colombian amazon region: you don't diagnose what you don't suspect. | malaria is a worldwide public health problem; parasites from the genus plasmodium spp. are the aetiological agent of this disease. the parasite is mainly diagnosed by microscope-based techniques. however, these have limited sensitivity. many asymptomatic infections are sub-microscopic and can only be detected by molecular methods. this study was aimed at comparing nested pcr results to those obtained by microscope for diagnosing malaria and to present epidemiological data regarding malaria in co ... | 2016 | 27899111 |
| plasmodium malariae and plasmodium ovale infections in the china-myanmar border area. | the greater mekong subregion is aiming to achieve regional malaria elimination by 2030. though a shift in malaria parasite species predominance by plasmodium vivax has been recently documented, the transmission of the two minor plasmodium species, plasmodium malariae and plasmodium ovale spp., is poorly characterized in the region. this study aims to determine the prevalence of these minor species in the china-myanmar border area and their genetic diversity. | 2016 | 27846879 |
| the role of plasmodium knowlesi in the history of malaria research. | in recent years, a malaria infection of humans in south east asia, originally diagnosed as a known human-infecting species, plasmodium malariae, has been identified as a simian parasite, plasmodium knowlesi. this species had been subject to considerable investigation in monkeys since the 1930s. with the development of continuous culture of the erythrocytic stages of the human malarial parasite, plasmodium falciparum in 1976, the emphasis in research shifted away from knowlesi. however, its impor ... | 2016 | 27829470 |
| molecular evidence of high rates of asymptomatic p. vivax infection and very low p. falciparum malaria in botswana. | botswana is one of eight sadc countries targeting malaria elimination by 2018. through spirited upscaling of control activities and passive surveillance, significant reductions in case incidence of plasmodium falciparum (0.96 - 0.01) was achieved between 2008 and 2012. as part of the elimination campaign, active detection of asymptomatic plasmodium species by a highly sensitive method was deemed necessary. this study was carried out to determine asymptomatic plasmodium species carriage by nested ... | 2016 | 27682611 |
| rarity of mixed species malaria with plasmodium falciparum and plasmodium malariae in travelers to saarland in germany. | malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. malaria is mainly brought over to germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. the aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. patient data were collected from hospital charts at the department of internal medicine, saarland ... | 2016 | 27645545 |
| prevalence of malaria, prevention measures, and main clinical features in febrile children admitted to the franceville regional hospital, gabon. | recently, major progress has been made in controlling malaria in africa. however, in gabon, little information is available on the role of malaria in childhood febrile syndromes, the use and efficacy of preventive measures, and plasmodium species distribution. here, we characterized malaria in febrile children in franceville, gabon through a cross-sectional study at the pediatric unit of the franceville regional hospital. we registered 940 febrile children. their general condition was markedly a ... | 2016 | 27492564 |
| transfusion-transmitted severe plasmodium knowlesi malaria in a splenectomized patient with beta-thalassaemia major in sabah, malaysia: a case report. | transfusion-transmitted malaria (ttm) is a well-recognized risk of receiving blood transfusions, and has occurred with plasmodium falciparum, plasmodium vivax, plasmodium ovale, and plasmodium malariae. the simian parasite plasmodium knowlesi is also known to be transmissible through inoculation of infected blood, and this species is now the most common cause of malaria in malaysia with a high rate of severity and fatal cases reported. no confirmed case of accidental transfusion-transmitted p. k ... | 2016 | 27405869 |
| rarity of mixed species malaria with plasmodium falciparum and plasmodium malariae in travelers to saarland in germany. | malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. malaria is mainly brought over to germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. the aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. patient data were collected from hospital charts at the department of internal medicine, saarland ... | 2016 | 27405448 |
| national malaria prevalence in cambodia: microscopy versus polymerase chain reaction estimates. | accurate information regarding malaria prevalence at national level is required to design and assess malaria control/elimination efforts. although many comparisons of microscopy and polymerase chain reaction (pcr)-based methods have been conducted, there is little published literature covering such comparisons in southeast asia especially at the national level. both microscopic examination and pcr detection were performed on blood films and dried blood spots samples collected from 8,067 individu ... | 2016 | 27402511 |
| low prevalence of plasmodium malariae and plasmodium ovale mono-infections among children in the democratic republic of the congo: a population-based, cross-sectional study. | in an effort to improve surveillance for epidemiological and clinical outcomes, rapid diagnostic tests (rdts) have become increasingly widespread as cost-effective and field-ready methods of malaria diagnosis. however, there are concerns that using rdts specific to plasmodium falciparum may lead to missed detection of other malaria species such as plasmodium malariae and plasmodium ovale. | 2016 | 27392905 |
| climate, environment and transmission of malaria. | malaria, the most common parasitic disease in the world, is transmitted to the human host by mosquitoes of the genus anopheles. the transmission of malaria requires the interaction between the host, the vector and the parasite.the four species of parasites responsible for human malaria are plasmodium falciparum, plasmodium ovale, plasmodium malariae and plasmodium vivax. occasionally humans can be infected by several simian species, like plasmodium knowlesi, recognised as a major cause of human ... | 2016 | 27367318 |
| common asymptomatic and submicroscopic malaria infections in western thailand revealed in longitudinal molecular and serological studies: a challenge to malaria elimination. | despite largely successful control efforts, malaria remains a significant public health problem in thailand. based on microscopy, the northwestern province of tak, once thailand's highest burden area, is now considered a low-transmission region. however, microscopy is insensitive to detect low-level parasitaemia, causing gross underestimation of parasite prevalence in areas where most infections are subpatent. the objective of this study was to assess the current epidemiology of malaria prevalen ... | 2016 | 27333893 |
| seroepidemiology of plasmodium species infections in zimbabwean population. | individuals living in malaria-endemic regions may be exposed to more than one plasmodium species; there is paucity of data on the distribution of the different species of plasmodium in affected populations, in part due to the diagnostic method of microscopy, which cannot easily differentiate between the species. sero-epidemiological data can overcome some of the shortcomings of microscopy. | 2016 | 27165412 |
| investigation on possible transmission of monkeys' plasmodium to human in a populations living in the equatorial rainforest of the democratic republic of congo. | plasmodiums are protozoa that may infect various hosts. only five species are now recognized as naturally parasitizing humans: plasmodium falciparum, plasmodium vivax, plasmodium malariae, plasmodium ovale and plasmodium knowlesi. this fifth species, p. knowlesi, previously identified as naturally parasitizing the monkey macaca fascicularis, has been microscopically confused for a long time with p. malariae or p. falciparum and it was not possible to correctly differentiate them until the advent ... | 2016 | 27141437 |
| limited polymorphism of the kelch propeller domain in plasmodium malariae and p. ovale isolates from thailand. | artemisinin resistance in plasmodium falciparum, the agent of severe malaria, is currently a major obstacle to malaria control in southeast asia. a gene named "kelch13" has been associated with artemisinin resistance in p. falciparum the orthologue of the kelch gene in p. vivax was identified and a small number of mutations were found in previous studies. the kelch orthologues in the other two human malaria parasites, p. malariae and p. ovale, have not yet been studied. therefore, in this study, ... | 2016 | 27114275 |
| clinical implications of a gradual dormancy concept in malaria. | malaria recurrences after an initially successful therapy and malarial fever occurring a long time after infection are well-known problems in malariology. currently, two distinct types of malaria recurrences are defined: recrudescence and relapse. a recrudescence is thought to originate from circulating plasmodium blood stages which do not cause fever before a certain level of a microscopically detectable parasitemia is reached. contrary, a relapse is thought to originate from quiescent intracel ... | 2016 | 27079460 |
| human malaria diagnosis using a single-step direct-pcr based on the plasmodium cytochrome oxidase iii gene. | nested pcrs based on the plasmodium 18s-rrna gene have been extensively used for human malaria diagnosis. however, they are not practical when large quantities of samples need to be processed, further there have been challenges in the performance and when interpreting results, especially when submicroscopic infections are analysed. here the use of "direct pcr" was investigated with the aim of improving diagnosis in the malaria elimination era. | 2016 | 26928594 |
| uk malaria treatment guidelines 2016. | 1.malaria is the tropical disease most commonly imported into the uk, with 1300-1800 cases reported each year, and 2-11 deaths. 2. approximately three quarters of reported malaria cases in the uk are caused by plasmodium falciparum, which is capable of invading a high proportion of red blood cells and rapidly leading to severe or life-threatening multi-organ disease. 3. most non-falciparum malaria cases are caused by plasmodium vivax; a few cases are caused by the other species of plasmodium: pl ... | 2016 | 26880088 |
| non-falciparum malaria infections in pregnant women in west africa. | non-plasmodium falciparum malaria infections are found in many parts of sub-saharan africa but little is known about their importance in pregnancy. | 2016 | 26823277 |
| performance of microscopy for the diagnosis of malaria and human african trypanosomiasis by diagnostic laboratories in the democratic republic of the congo: results of a nation-wide external quality assessment. | the present external quality assessment (eqa) assessed microscopy of blood parasites among diagnostic laboratories in the democratic republic of the congo. the eqa addressed 445 participants in 10/11 provinces (october 2013-april 2014). participants were sent a panel of five slides and asked to return a routinely stained slide which was assessed for quality of preparation and staining. response rate was 89.9% (400/445). for slide 1 (no parasites), 30.6% participants reported malaria, mostly plas ... | 2016 | 26788725 |
| loop-mediated isothermal amplification assay for identification of five human plasmodium species in malaysia. | the lack of rapid, affordable, and accurate diagnostic tests represents the primary hurdle affecting malaria surveillance in resource- and expertise-limited areas. loop-mediated isothermal amplification (lamp) is a sensitive, rapid, and cheap diagnostic method. five species-specific lamp assays were developed based on 18s rrna gene. sensitivity and specificity of lamp results were calculated as compared with microscopic examination and nested polymerase chain reaction. lamp reactions were highly ... | 2016 | 26598573 |
| entomological aspects and the role of human behaviour in malaria transmission in a highland region of the republic of yemen. | the republic of yemen has the highest incidence of malaria in the arabian peninsula, yet little is known of its vectors or transmission dynamics. | 2016 | 26932794 |
| malaria in three epidemiological strata in mauritania. | malaria epidemiology in mauritania has been characterized on the basis of epidemiological strata, defined by climatic and geographic features, which divide the country into three zones: sahelian zone, sahelo-saharan transition zone, and saharan zone. the association between geographic stratification and malaria transmission was assessed through a series of parasitological and entomological surveys. | 2016 | 27068219 |
| persistent parasitism: the adaptive biology of malariae and ovale malaria. | plasmodium malariae causes malaria in humans throughout the tropics and subtropics. plasmodium ovale curtisi and plasmodium ovale wallikeri are sympatric sibling species common in sub-saharan africa and also found in oceania and asia. although rarely identified as the cause of malaria cases in endemic countries, pcr detection has confirmed all three parasite species to be more prevalent, and persistent, than previously thought. chronic, low-density, multispecies asymptomatic infection is a succe ... | 2016 | 27480365 |
| asymptomatic plasmodium infections in children in low malaria transmission setting, southwestern uganda(1). | a survey of asymptomatic children in uganda showed plasmodium malariae and p. falciparum parasites in 45% and 55% of microscopy-positive samples, respectively. although 36% of microscopy-positive samples were negative by rapid diagnostic test, 75% showed p. malariae or p. ovale parasites by pcr, indicating that routine diagnostic testing misses many non-p. falciparum malarial infections. | 2016 | 27434741 |
| genome-scale comparison of expanded gene families in plasmodium ovale wallikeri and plasmodium ovale curtisi with plasmodium malariae and with other plasmodium species. | malaria in humans is caused by six species of plasmodium parasites, of which the nuclear genome sequences for the two plasmodium ovale spp., p. ovale curtisi and p. ovale wallikeri, and plasmodium malariae have not yet been analyzed. here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. plasmodium ovale curtisi and p. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric range ... | 2016 | 27392654 |
| [fever and chills in an 85-year-old woman]. | 2016 | 27321571 | |
| transfusion-transmitted malaria not preventable by current blood donor screening guidelines: a case report. | transfusion-transmitted malaria (ttm) is a well-known, though rare, entity in the united states with only 100 cases previously reported. with no food and drug administration-approved screening tests of donated blood for malaria in the united states, prevention relies solely on deferral of the highest-risk donors. we present a case of ttm not preventable by these guidelines. | 2016 | 27297115 |
| mouse-based research on quiescent primate malaria parasites. | mice engrafted with primate tissue make two important plasmodial dormancy-related questions researchable. the first is concerned with whether latent merozoites in the lymphatic system can give rise to relapse-like, recurrent malaria in primates. the second is that genetic evidence of hypnozoite activation as the source of relapsing primate malaria can be looked for. | 2016 | 26961183 |
| multi-method assessment of patients with febrile illness reveals over-diagnosis of malaria in rural uganda. | health clinics in rural africa are typically resource-limited. as a result, many patients presenting with fever are treated with anti-malarial drugs based only on clinical presentation. this is a considerable issue in uganda, where malaria is routinely over-diagnosed and over-treated, constituting a wastage of resources and an elevated risk of mortality in wrongly diagnosed patients. however, rapid diagnostic tests (rdts) for malaria are increasingly being used in health facilities. being fast, ... | 2016 | 27604542 |
| the host specificity of ape malaria parasites can be broken in confined environments. | recent studies have revealed a large diversity of plasmodium spp. among african great apes. some of these species are related to plasmodium falciparum, the most virulent agent of human malaria (subgenus laverania), and others to plasmodium ovale, plasmodium malariae and plasmodium vivax (subgenus plasmodium), three other human malaria agents. laverania parasites exhibit strict host specificity in their natural environment. plasmodium reichenowi, plasmodium billcollinsi, plasmodium billbrayi and ... | 2016 | 27486075 |
| identification of plasmodium spp. in neotropical primates of maranhense amazon in northeast brazil. | in the brazilian amazon region, malaria caused by plasmodium malariae is considered to be a zoonosis because of cross-transfer of the parasite between humans and neotropical primates. to contribute information on this issue, we investigated occurrences of natural infection with plasmodium sp. among neotropical primates in the maranhense amazon (amazon region of the state of maranhão), in the northeastern region of brazil. blood samples were collected from 161 neotropical primates of six species ... | 2017 | 28796820 |
| malaria in the guangxi zhuang autonomous region in china: a twelve-year surveillance data study. | the incidence of an indigenous malaria, defined as malaria acquired by a local mosquito transmission, declined from 2004 to 2015 in the guangxi zhuang autonomous region. however, imported malaria, defined as malaria acquired from other endemic regions outside of china, has been increasing in the region, as in the rest of the country, particularly the disease caused by plasmodium falciparum. a retrospective study was conducted to explore malaria-endemic characteristics in guangxi during the 2004- ... | 2017 | 28820683 |
| cryptic plasmodium ovale concurrent with mixed plasmodium falciparum and plasmodium malariae infection in two children from central african republic. | since several malaria parasite species are usually present in a particular area, co-infections with more than one species of plasmodium are more likely to occur in humans infected in these areas. in many mixed infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. | 2017 | 28810865 |
| non-falciparum malaria imported mainly from africa: a review from a portuguese hospital. | non-falciparum malaria (nfm) has been reported to be responsible for around 25% of imported malaria cases in europe but is often neglected due to its less severe clinical course when compared to plasmodium falciparum. differentiation between species is however crucial for a correct approach. the objective of this study is to report the cases of this often missed aetiology of malaria in a tertiary hospital in portugal. | 2017 | 28743266 |
| a dual colour fluorescence in situ hybridization (fish) assay for identifying the zoonotic malaria parasite plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of southeast asia. | plasmodium knowlesi is primarily responsible for zoonotic malaria in several southeast asian countries. precise identification of the parasite in the blood of patients presently relies on an expensive and elaborate pcr procedure because microscopic examination of blood and other available field identification techniques lack adequate specificity. therefore, the use of a simple and inexpensive dual-colour fluorescence in situ hybridization (fish) assay, analogous to fish assays recently described ... | 2017 | 28724402 |
| malaria in brazil, colombia, peru and venezuela: current challenges in malaria control and elimination. | in spite of significant progress towards malaria control and elimination achieved in south america in the 2000s, this mosquito-transmitted tropical disease remains an important public health concern in the region. most malaria cases in south america come from amazon rain forest areas in northern countries, where more than half of malaria is caused by plasmodium vivax, while plasmodium falciparum malaria incidence has decreased in recent years. this review discusses current malaria data, policies ... | 2017 | 28676055 |
| malaria pathogenesis. | in the mosquito-human life cycle, the six species of malaria parasites infecting humans (plasmodium falciparum, plasmodium vivax, plasmodium ovale wallickeri, plasmodium ovale curtisi, plasmodium malariae, and plasmodium knowlesi) undergo 10 or more morphological states, replicate from single to 10,000+ cells, and vary in total population from one to many more than 10(6) organisms. in the human host, only a small number of these morphological stages lead to clinical disease and the vast majority ... | 2017 | 28533315 |
| evaluation of the utility value of three diagnostic methods in the detection of malaria parasites in endemic area. | malaria is a debilitating disease with high morbidity and mortality in africa, commonly caused by different species of the genus plasmodium in humans. misdiagnosis is a major challenge in endemic areas because of other disease complications and technical expertise of the medical laboratory staff. microscopic method using giemsa-stained blood film has been the mainstay of diagnosis of malaria. however, since 1993 when rapid diagnostic test (rdt) kits were introduced, they have proved to be effect ... | 2017 | 28477621 |
| nested multiplex pcr for identification and detection of human plasmodium species including plasmodium knowlesi. | to develop a new technique for diagnosis of plasmodium knowlesi and at the same time to be able to discriminate among the diverse species of plasmodium causing human malaria. | 2017 | 28442114 |
| prevalence of plasmodium falciparum and non-p. falciparum infections in a highland district in ghana, and the influence of hiv and sickle cell disease. | in the past two decades, there has been a reported decline in malaria in ghana and the rest of the world; yet it remains the number one cause of mortality and morbidity. human immuno-deficiency virus (hiv) and sickle cell disease (scd) share a common geographical space with malaria in sub-saharan africa and an interaction between these three conditions has been suggested. this study determined the plasmodium falciparum and non-p. falciparum status of symptomatic and non-symptomatic residents of ... | 2017 | 28438159 |
| metal-dna interactions improve signal in high-resolution melting of dna for species differentiation of plasmodium parasite. | the success of high-resolution melting (hrm) analysis for distinguishing similar dnas with minor base mismatch differences is limited. here, metal-mediated structural change in dna has been exploited to amplify hrm signals leading to differentiation of target dnas in an orthologous gene corresponding to four plasmodium species. conserved 26-mer ssdnas from ldh gene of the four plasmodium species were employed as targets. a capture probe (cp) that is fully complementary to the plasmodium falcipar ... | 2017 | 28421327 |
| plasmodium knowlesi malaria in a traveller returning from the philippines to italy, 2016. | plasmodium knowlesi is a simian parasite responsible for most human cases of malaria in malaysian borneo. a timely recognition of infection is crucial because of the risk of severe disease due to the rapid increase in parasitemia. we report a case of p. knowlesi infection in a traveller who developed fever and thrombocytopenia after returning from the philippines in 2016. rapid antigen test was negative, microscopy examination showed parasites similar to plasmodium malariae, with a parasite coun ... | 2017 | 28675245 |
| genomic characterization of recrudescent plasmodium malariae after treatment with artemether/lumefantrine. | plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. we present a case of a p. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. by using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. haplotypic analysis of the c ... | 2017 | 28430103 |
| failure of atovaquone-proguanil chemoprophylaxis and chloroquine treatment in plasmodium malariae infection. | 2017 | 27546283 | |
| asymptomatic plasmodium malariae infections in children from suburban areas of yaoundé, cameroon. | the gold standard for malaria diagnosis is the microscopic examination of giemsa stained thick blood smears though microscopy mostly may not detect the presence of plasmodium species infections in asymptomatic samples. in the reported study, we used two diagnostic methods viz. the conventional microscopic examination and polymerase chain reaction (pcr) assay to analyse the asymptomatic malaria samples. pcr assay amplifying 18s small-subunit ribosomal rna (ssu rrna) gene of plasmodium in 122 samp ... | 2017 | 28263883 |
| plasmodium malariae and p. ovale genomes provide insights into malaria parasite evolution. | elucidation of the evolutionary history and interrelatedness of plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: p. malariae and two p. ovale species (p. o. curtisi and p. o. wallikeri). these species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. the exact evolutionary relationship of these species to the ... | 2017 | 28117441 |
| contribution of plasmodium knowlesi to multi-species human malaria infections in north sumatera, indonesia. | 2017 | 28201638 | |
| complicated vivax malaria, an often underestimated condition - case report. | malaria is a vector-borne disease that is endemic in 91 countries. south east asia is the second most affected region in the world, with india carrying the highest burden of the disease. four species of plasmodium are known to cause malaria in humans. plasmodium vivax and plasmodium falciparum are the most common species found in india, but plasmodium malariae have also been reported. severe complications of malaria have been more commonly seen in p. falciparum infections, and those caused by p. ... | 2017 | 26392800 |
| rarity of mixed species malaria with plasmodium falciparum and plasmodium malariae in travelers to saarland in germany. | malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. malaria is mainly brought over to germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. the aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. patient data were collected from hospital charts at the department of internal medicine, saarland ... | 2017 | 27826886 |
| dissecting malaria biology and epidemiology using population genetics and genomics. | molecular approaches have an increasingly recognized utility in surveillance of malaria parasite populations, not only in defining prevalence and incidence with higher sensitivity than traditional methods, but also in monitoring local and regional parasite transmission patterns. in this review, we provide an overview of population genetic and genomic studies of human-infecting plasmodium species, highlighting recent advances in the field. in accordance with the renewed impetus for malaria eradic ... | 2017 | 27825828 |
| late manifestation of a mixed plasmodium falciparum and plasmodium malariae infection in a non-immune toddler after traveling to chad. | 2017 | 27238908 | |
| plasmodium knowlesi and human malaria parasites in khan phu, vietnam: gametocyte production in humans and frequent co-infection of mosquitoes. | four species of malaria parasite, plasmodium falciparum, plasmodium vivax, plasmodium malariae and plasmodium knowlesi infect humans living in the khanh phu commune, khanh hoa province, vietnam. the latter species also infects wild macaque monkeys in this region. in order to understand the transmission dynamics of the three species, we attempted to detect gametocytes of the three species in the blood of infected individuals, and sporozoites in the salivary glands of mosquitoes from the same regi ... | 2017 | 27894375 |
| transfusion-transmitted malaria in iran: a narrative review article. | malaria is the most important transfusion-transmitted infection (tti) in worldwide after viral hepatitis and human immunodeficiency virus (hiv) infection. the main objective of the present study was to review and evaluate the transmission of malaria via blood transfusion in iran. | 2017 | 28096847 |
| new potential plasmodium brasilianum hosts: tamarin and marmoset monkeys (family callitrichidae). | non-human primates (nhps) as a source for plasmodium infections in humans are a challenge for malaria elimination. in brazil, two species of plasmodium have been described infecting nhps, plasmodium brasilianum and plasmodium simium. both species are infective to man. plasmodium brasilianum resembles morphologically, genetically and immunologically the human quartan plasmodium malariae. plasmodium brasilianum naturally infects species of non-human primates from all new world monkey families from ... | 2017 | 28187764 |