Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| clinical assessment and management of dapsone-resistant leprosy for the field worker. | 1977 | 330996 | |
| sulphone resistance and its implications. | 1977 | 330997 | |
| management of sulphone-resistant lepromatous leprosy. | 1977 | 330998 | |
| primary dapsone-resistant leprosy. | 1977 | 330999 | |
| dapsone-resistant leprosy and its implications for leprosy control programmes. | 1977 | 331000 | |
| the diagnosis and management of dapsone-resistant leprosy. | 1977 | 331001 | |
| in vitro cultivation of mycobacteria from human lepromas and from an armadillo infected with mycobacterium leprae. | 1977 | 332644 | |
| oxidation of substrates by host grown mycobacterium leprae and mycobacterium lepraemurium and by in vitro grown mycobacteria cultured from human armadillo and murine lepromas. | 1977 | 332645 | |
| the janus-face of mycobacterium leprae: characteristics of in vitro grown m. leprae are not predictable. | 1977 | 332647 | |
| dopa oxidation and m. leprae. | 1977 | 332648 | |
| transfer of leprosy bacilli from patients to mouse footpads by aedes aegypti. | aedes aegypti mosquitoes which were first allowed to feed on untreated lepromatous leprosy patients, and then to refeed on mouse footpads were found to transfer mycobacterium leprae to the footpads as seen by the subsequent multiplication of the bacilli in the footpads. results presently available are insufficient to come to any conclusion about the actual role of mosquitoes in the transmission of leprosy in the field. | 1977 | 333183 |
| further potential sources of energy modifying the multiplication of mycobacterium leprae. | the multiplication of mycobacterium leprae was modified by graded dilutions of organic acids. 0.01%-0.05% gluconic acid inhibited its multiplication. 0.005% of it promoted the growth of 2 out of 6 strains. 0.2% - 1.0% glucuronic acid promoted the multiplication of the majority of strains. 2.0% inhibited their multiplication, and 0.05% promoted the growth of one strain. galacturonic and pyruvic acids were active in 0.2 - 2.0% concentrations, while the activity of citric acid was mainly noted at 1 ... | 1977 | 334196 |
| are all nonsolid mycobacterium leprae dead? does a negative finding in the mouse foot pad indicate that there is actually no growth of m. leprae in the animals? | ever since the discovery of the foot pad technic for growth of m. leprae in mice, investigators have overemphasized the laboratory results in clinical applications. overenthusiasm has led to some dire results in the leprosy field. two well-known examples can be cited, which are based on the presumption that: a) all the nonsolidly stained m. leprae are dead, and b) that a negative finding in the mouse foot pad indicates no growth of m. leprae in the animals. the former led clinical investigators ... | 1977 | 336555 |
| freeze-etching study of human and murine leprosy bacilli. | morphologic features of the electron transparent zone (etz) material around human and murine leprosy bacilli were examined by a freeze-etching technic. the etz around human leprosy bacilli is composed of spherical droplets of hydrophobic material. these are always liquid at body temperature and they never show crystalline lamellar structure even at the temperature of liquid nitrogen. the etz around murine leprosy bacilli is composed of ribbon-like or membranous crystalline structures. this mater ... | 1977 | 336556 |
| culture and phagocytic characteristics of schwann cells in vitro. a possible model substrate for cultivation of m. leprae. | tissue cultures of five acoustic and four spinal schwannomas demonstrated good growth and migration of schwann cells within two to four days. two types of cells corresponding to antoni type a tissue and antoni type b tissue were clearly recognized. both these cell types showed avid phagocytosis when the cultures were inoculated with mycobacteria, either icrc bacilli or m. leprae. the phagocytic index was 95% at the end of two hours. the schwann cells grown in vitro also showed intense acid phosp ... | 1977 | 336557 |
| transfer factor as a probe of the immune defect in lepromatous leprosy. | 1977 | 336558 | |
| has m. leprae been cultured already? response to kato (ijl 45/2, editorial) | 1977 | 336560 | |
| vaccine development in leprosy. | 1977 | 336561 | |
| determination of the mass of mycobacterium leprae by electron microscopy. | the mass of mycobacterium leprae, obtained as a pure suspension from tissues of infected armadillos, was measured electron microscopically using a technique that avoids the need for standards of mass. the mean mass of an individual bacterium was 3-9+/-1-0 (s.d.) x 10(-14) g. comparative measurements were also made on a small sample of m. lepraemurium (whose mass is known). calculation of the mass of an individual bacterium allows numbers of bacteria in samples to be estimated by direct weighing ... | 1977 | 336841 |
| naturally acquired leprosy-like disease in the nine-banded armadillo (dasypus novemcinctus): reactions in leprosy patients to lepromins prepared from naturally infected armadillos. | 1977 | 336883 | |
| oxidation of various substrates by host grown mycobacteria leprae and m. lepraemurium. | oxidation of various substrates by whole cell suspensions of m. lepraemurium and m. leprae was investigated using manometric techniques. yeast extract, l-cysteine, dithioerythritol, and dl-penicillamine were oxidized by both m. lepraemurium as well as by m. leprae. although tween 80 was oxidized by m. lepraemurium cell suspensions, it was not by m. leprae. succinate was readily oxidized by whole cells of m. leprae (without being frozen) whereas it was oxidized only by m. lepraemurium cells froze ... | 1977 | 337415 |
| mycobacteria from leprous tissue of an armadillo cultivated on a hyaluronic acid based medium. | mycobacteria were isolated from pooled leprous tissues of an armadillo. the suspensions of acid fast bacilli obtained were inoculated into a culture medium composed of umbilical cord extract, supplemented with yeast extract powder and glycerol with sheep serum added. incubation temperature was 34 degrees c. an abundant growth of mycobacteria was observed in the primo culture in four weeks. the culture was easily sub-cultured on the homologous media. the primo culture did not grow on loëwenstein ... | 1977 | 337416 |
| circulating t-cell numbers and their mitogenic potential in leprosy--correlation with mycobacterial load. | the effect of treatment and mycobacterial load on circulating t-cell numbers and their functional ability was investigated in forty-one patients with leprosy. both early binding t cells and their responses to phytohaemagglutinin (pha), concanavalin a (con a) and pokeweed mitogen (pwm) were profoundly and uniformly depressed in untreated, and partially treated, bacilleferous lepromatous leprosy (ll) patients as compared with normal subjects and tuberculoid patients. on elimination of mycobacteria ... | 1977 | 338218 |
| antibody response in rabbits to immunization with mycobacterium leprae. | mycobacterium leprae purified from liver tissue of an infected armadillo (the a/10 preparation) was tested for antigenic composition by immunization of rabbits and characterization of the antibody response by crossed immunoelectrophoresis. the rabbit antisera detected seven distinct components in the m. leprae preparation. this number is far lower than in similar experiments with other mycobacteria. the m. leprae sonic extract gave far fewer lines after polyacrylamide gel electrophoresis and sta ... | 1977 | 338491 |
| hydnocarpus oil as an antileprotic agent in footpad technique. | hydnocarpus oil alone and mixed with dapsone in food and fed to the mice infected with mycobacterium leprae; showed inhibition of the growth of the lepra bacilli, both sensitive and resistant to dapsone. there was an additive inhibitory effect of the combination of dapsone and oil on the growth of bacilli. | 1977 | 338984 |
| hypopigmentation of skin lesions in leprosy--a hypothesis. | 1977 | 338986 | |
| growth of sulfone-resistant m. leprae in the foot pads of mice fed dapsone. | 1977 | 339229 | |
| a study of cellular and humoral immunity in three species of armadillos. part i. | in the present study the membrane receptors of immunocompetent cells and immunoglobulins in three varieties of armadillos were explored for determining, in later studies, the possible differences in inoculated animals developing leprosy. the studies of cellular immunity were performed in five chaetophroctus villosus (ch.v), one dasypus hibridus septecinctus (dhs) and one zaedus pichei (zp), while the humoral immunity was studied with a serum pool of 17 ch.v and 6 dhs. the results obtained demons ... | 1977 | 344239 |
| [a study on transition of bacillary indices by chemotherapy of leprosy (author's transl)]. | 1977 | 361674 | |
| in vitro resistance test of human leprosy bacilli to anti-leprous drugs. | sensitivity to anti-leprous drugs of m. leprae isolated from an l-type leprosy patient was tested using m--y 14b liquid medium by direct and indirect methods. the results revealed that the strain, sr61-l74, was almost completely resistant to dds, and responded only to the long-term administration of streptomycin and isoniazid. however, the strain was completely sensitive to rifampicin which had never been administered previously. the subsequent administration of rifampicin resulted in a rapid im ... | 1977 | 366337 |
| comparative study of skin reactions in leprosy patients to m. leprae-lepromin and to icrc-in, an antigen from cultivable acid-fast bacilli from m. leprae isolated from lepromatous nodules. | skin test antigens (dharmendra type) were prepared from fresh m. leprae (lepromin) and from a culture of strain c-44 icrc bacilli (icrcin) grown 'in vitro' from m. leprae isolate from lepromatous nodules. comparative study of skin reactivity to lepromin and icrcin--both "early" and "late" reactions in 76 leprosy patients was conducted. in 29 lepromatous (ll) cases, 25 exhibited totally negative reaction at the end of third week. in tuberculoid (tt) 22 and 23 out of 31 were positive (greater than ... | 1977 | 342823 |
| tissue lipids in leprosy. | a total of 30 cases of leprosy (15 lepromatous and 15 tuberculoid) were studied by histochemical procedures for lipids in the morbid skin. the possible origin and relation of lipids to the presence of lepra bacilli in the lepra cells is discussed. | 1977 | 342825 |
| the chemotherapy of leprosy from a microbiological standpoint. | the increased knowledge concerning microbiology and chemotherapy of leprosy is exposed. great stress is put on the knowledge of chemotherapy of tuberculosis that has accumulated during the last two decades and the guidelines that are equally valid for the chemotherapy of leprosy. the problems of the chemotherapy of the different forms of the disease are exposed and future lines of research indicated. | 1977 | 342826 |
| dapsone alone compared with dapsone plus rifampicin in short-term therapy of lepromatous leprosy. | 1977 | 400806 | |
| viability of mycobacterium leprae outside the human body. | 1977 | 400807 | |
| some characteristics of the action of dapsone on multiplication of mycobacterium leprae in the mouse. | 1977 | 400808 | |
| report of the third immlep scientific working group meeting. 21-25 february 1977. | 1977 | 400809 | |
| the treatment of leprosy today and tomorrow: the lepra consultation on chemotherapy. | 1977 | 400810 | |
| the hypothesis of skin to skin transmission. | 1977 | 400811 | |
| lack of protection afforded by ribonucleic acid preparations from mycobacterium tuberculosis against mycobacterium leprae infections in mice. | mycobacterial ribonucleic acid preparations from h37ra, an attenuated strain of mycobacterium tuberculosis, provide their usual marked protection against m. tuberculosis challenge; however, they provided no protection against mycobacterium leprae challenge. suspensions of intact h37ra were not effective against m. leprae. suspensions of bcg gave their usual distinct protection against m. leprae challenge. | 1977 | 404242 |
| o-diphenoloxidase in mycobacterium leprae. | 1977 | 406210 | |
| antibodies against bcg antigen 60 in mycobacterial infection. | a sensitive specific radioimmunoassay was developed to measure antibodies against bcg antigen 60, a prominent antigenic component of bcg bacilli which cross-reacts with similar components in many mycobacterial species including mycobacterium leprae and m tuberculosis. a lepromatous serum pool had anti-bcg-60 activity with a titre of 10(5) and the tuberculoid pool a titre of 10(4). testing of individual sera showed striking variations within groups of patients with lepromatous and tuberculoid lep ... | 1977 | 407965 |
| [research in the campaign against leprosy (author's transl)]. | "leprosy relief through leprosy research" means that the results of research are made available for curing and eradicating the disease. the "marinum model" and the "planter test in mice" are, along with determination of serum activity in healthy test subjects, part of a complex of experiments for the assessment of the therapeutic value of an antimycobacterial substance. this replaces the "controlled studies" which, in their proper form, are scarcely possible for leprosy. with the recently develo ... | 1977 | 408667 |
| a study of alleged leprosy bacillus strain hi-75. | subcultures of strain hi-75 of skinsnes leprosy bacillus received in antwerp and london have been studied bacteriologically and compared. both contained moderately large acid-fast bacilli readily subcultured and maintained on ordinary mycobacteriologic media. these organisms were found to be a variety of mycobacterium marianum (syn. serofulaceum) and were considered likely to be a laboratory contaminant. the earlier subculture studied also contained numbers of a much smaller mycobacterium (of a ... | 1977 | 409691 |
| lack of observed association between armadillo contact and leprosy in humans. | in 1971 it was discovered that the nine-banded armadillo (dasypus novemcinctus) could be infected in the laboratory with mycobacterium leprae, and would manifest disease similar to the lepromatous form of leprosy in man. in 1975 several wild armadillos captured in louisiana were found to have a disease identical to the m. laprae infection in laboratory animals. to determine if there is a significant association between contact with armadillos and presence of leprosy in humans, the armadillo cont ... | 1977 | 557294 |
| cell-mediated immune response in mycobacterium leprae infected mice. | positive skin reactions to homologous antigens in mice infected with mycobacterium leprae were observed at the time that the bacillary multiplication was nearing the plateua level. once developed, the skin reactivity persisted for a considerable length of time. lymphocyte transformation studies indicated that the lymphocytes from infected animals were unable to respond to specific antigenic stimuli in the early phase of infection. possible explanation for this failure could be that the lymphocyt ... | 1977 | 562855 |
| serum and tissue lysozyme in leprosy. | mean serum lysozyme values were found to be elevated in untreated leprosy patients. statistically significant elevations were present in each of the three major categories of leprosy, tuberculoid, borderline, and lepromatous. values were particularly high in patients with severe reversal reactions or lucio's phenomenon. prolonged sulfone therapy was associated with a fall in serum lysozyme values. with an immunoperoxidase method to localize lysozyme in leprous tissues, two distinct staining patt ... | 1977 | 591069 |
| acedapsone treatment of leprosy patients: response versus drug disposition. | in 22 lepromatous filipino patients receiving their first injection of 225 mg acedapsone (dadds), dapsone (dds), and monoacetyl dds (madds) were present in plasma in approximately equal quantities. peak levels of parent drug, dds, and madds occurred between 22 and 35 days. the half-times of disappearance (t1/2) from plasma were 43 days for dds and madds and 46 days for dadds. acetylator phenotyping with sulfamethazine (smz) and dds showed that 17 patients were rapid and 5 patients were slow acet ... | 1977 | 842774 |
| on the mode of transmission of mycobacterium leprae. | 1977 | 853838 | |
| activity of three new rifamycin derivates on the experimental infection by mycobacterium leprae. | 1977 | 883857 | |
| the effect on the multiplication of mycobacterium leprae of irregular administration of dapsone to mice. results of the total minimal inhibitory test. | 1977 | 883858 | |
| spontaneous leprosy-like disease in a chimpanzee. | the clinical and laboratory findings of a spontaneous disease, resembling human leprosy, in a chimpanzee are described. the disease was a chronic progressive dermatitis characterized by nodular thickenings of the dermis and involving the ears, eyebrows, nostrils, and lips. a maculopapular rash was also present. numerous acid-fast organisms were found in nasal swabs and in dermal lesions, including nerves. attempts to culture acid-fast organisms in artificial media have failed. at this time, the ... | 1977 | 886203 |
| misconceptions about enzyme activity of mycobacterium leprae. | 1977 | 415179 | |
| criteria for establishing o-diphenoloxidase activity. | 1977 | 415992 | |
| the role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro. | peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by mycobacterium leprae antigens. in contrast, we found that t cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to m. leprae. conversely, t cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. it seems, therefore, tha ... | 1978 | 373933 |
| cutaneous leishmaniasis and leprosy. | eight patients who had concomitant leprosy and leishmaniasis are described. two patients with lepromatous leprosy had high resistance leishmaniasis, implying that the immune deficiency in lepromatous leprosy is specific to mycobacterium leprae. | 1978 | 653788 |
| reversal reaction in patients with lepromatous leprosy after transplantation of human fetal thymic grafts. | an attempt has been made to reconstitute impaired cell-mediated immunity in 1 patient with indeterminate, 4 patients with borderline and 2 patients with polar lepromatous leprosy by grafting three thymus glands obtained from human fetuses of 14--19 weeks gestation. most of these patients had severe ulcerative erythema nodosum leprosum (enl) and were intolerant to dapsone. after thymus transplantation these patients were followed for 1 1/2 years. during this period, all conventional chemotherapy ... | 1978 | 664571 |
| combinations of rifampicin and isoprodian in the treatment of mycobacterium leprae infections in mice. | 1978 | 701209 | |
| reversal reactions in lepromatous leprosy following transfer factor therapy. | five patients with active leprosy, four with polar lepromatous (ll) and one with borderline lepromatous (bl) disease, were each treated with transfer factor (tf) from approximately 7.4 x 10(9) lymphocytes given in 36 divided doses over a 12-week period. the tf was prepared from blood donated by normal, healthy, lepromin skin test-positive individuals. during treatment all four of the ll patients, but not the bl patient, developed clinical reversal reactions. histopathologically, skin biopsies in ... | 1978 | 717642 |
| gut-associated iga deficiency in lepromatous leprosy. | sera, intestinal secretions and intestinal biopsies were collected from twelve biopsy-proved lepromatous leprosy patients with the help of a capsule invented by roy choudhury. sera from another twenty-five proved lepromatous cases were also included. sera and intestinal aspirates from twenty-five normal subjects and twenty patients with intestinal tuberculosis were also taken as controls. acid-fast organisms, morphologically resembling mycobacterium leprae, were detected in the intestinal aspira ... | 1978 | 725534 |
| activity of derivatives and analogs of dapsone against mycobacterium leprae. | of 25 dapsone derivatives and analogs screened for activity against mycobacterium leprae in the mouse footpad system, only 7 were active. all seven were metabolized to or contaminated with dapsone. | 1978 | 727767 |
| immunological relatedness of ribosomes from mycobacteria, nocardiae and corynebacteria, and microorganisms in leprosy lesions. | serological relatedness of ribosomes from microorganisms of the mycobacterium, nocardia, and corynebacterium genera has been analyzed by the microplate immunodiffusion technique. mycobacterium and nocardia proved homogeneous and closely related taxa, whereas corynebacterium was found to be a heterogeneous phylum connected by remote links to the others. the taxonomic position of "diphtheroid microorganisms" (non-acid-fast, gram-positive bacteria morphologically similar to corynebactria), which we ... | 1978 | 730371 |
| development of hodgkin's disease in a patient with leprosy. | we present a patient with leprosy who developed hodgkin's disease of the nodular sclerosing type. there are two previous reports describing the combination of leprosy and hodgkin's disease in a single patient [3, 9]. hodgkin's disease was diagnosed 14 months after the complete disappearance of mycobacterium leprae from the skin lesions, under treatment with dds (diamino-diphenyl-sulfone). hodgkin's disease was treated by irradiation and chemotherapy. obstructive jaundice developed which resolved ... | 1978 | 745813 |
| induction of cell-mediated immunity to mycobacterium leprae in mice. | the immune response of mice to armadillo-derived, irradiation-killed mycobacterium leprae (i-ml) was investigated. following injection of 100 microgram of i-ml into the left hind footpads of mice, a state of cell-mediated immunity (cmi) was engendered to antigens of m. leprae. the evidence for cmi was as follows: (i) development of delayed-type hypersensitivity to both human tuberculin purified protein derivative and soluble m. leprae antigens; (ii) t-lymphocyte-dependent macrophage activation a ... | 1978 | 415009 |
| leprosy-like disease of wild armadillos in french acadiana, louisiana. | 1978 | 376833 | |
| interaction of mycobacterium leprae and mycobacteriophage d29. | this study of the interaction between mycobacterium leprae and the mycobacteriophage d29 showed that the viruses caused a patchy damage of cell wall structure and the accumulation in the host of internal crystalline structures. whether the observed ultrastructural alterations were caused by the replication of d29 was not clear. mitomycin c also caused the accumulation of crystalline structures in m. leprae. | 1978 | 382947 |
| immunity to mycobacterium leprae infections induced in mice by bcg vaccination at different times before or after challenge. | viable suspensions of bcg, an attenuated strain of mycobacterium bovis, have been previously shown to immunize mice against infections with m. leprae. usually, the mice have been vaccinated about 1 month before challenge. experiments have now been carried out with single intradermal injections of bcg given before or after the m. leprae challenge. approximately equal immunizing effect was seen in one experiment when the bcg was given at -168, -119, -70, and -28 days relative to challenge. approxi ... | 1978 | 344208 |
| experimental lepromatous leprosy in the white-handed gibbon (hylobatus lar): successful inoculation with leprosy bacilli of human origin. | leprosy bacilli of human origin were inoculated into a white-handed gibbon by the i.v. and i.p. routes, and also locally into ears, testis and around an ulnar nerve. the animal was observed closely during a period of nearly 15 years and did not exhibit any clinical evidence of cutaneous or neurological disease. at death, a wide range of tissues was taken for bacterial counts and histological examination, and a disseminated and progressive infection was demonstrated. acid-fast bacilli were found ... | 1978 | 371653 |
| development of an anti-leprosy vaccine -- progress in dharmendra. | 1978 | 374867 | |
| towards development of a vaccine against leprosy. introduction. | 1978 | 374868 | |
| five cultivable mycobacterial strains giving blast transformation and leukocyte migration inhibition of leukocytes analogous to mycobacterium leprae. | 1978 | 374869 | |
| delayed hypersensitivity skin reactions to homologous and heterologous antigens in guinea-pigs immunized with m. leprae and four selected cultivable mycobacterial strains. | 1978 | 374870 | |
| ability of m. leprae, mycobacterium w, and icrc bacillus to produce macrophage activating factors from lymphocytes of leprosy patients. | 1978 | 374871 | |
| delayed hypersensitivity skin reactions to lepromin and antigens prepared from four other mycobacteria. | 1978 | 374872 | |
| results of skin tests with five different mycobacteria. | 1978 | 374873 | |
| delayed hypersensitivity skin reactions to lepromins prepared from m. leprae and selected cultivable mycobacteria. investigations at the victoria hospital, dichpalli. | 1978 | 374874 | |
| early and late reactions in tuberculoid and lepromatous leprosy patients with lepromins from mycobacterium leprae and five selected cultivable mycobacteria. | 1978 | 374875 | |
| comparative study of skin reactions in leprosy patients to m. leprae-lepromin and to antigens from cultivable saprophytic mycobacteria. | 1978 | 374876 | |
| concluding comments on development of a vaccine against leprosy. | 1978 | 374877 | |
| assessment of dharmendra antigen. | 1978 | 374878 | |
| immunohistochemical observation of lysozyme in macrophages in leprosy. | lysozyme activities of skin granulomas of 24 patients in leprosy were studied. lepra cells of all 15 lepromatous leprosy showed strong lysozyme activity in cytoplasma. in the specimens stained with lysozyme and ziehl-neelsen's carbolfuchsin double stain conspicuous lysozyme activity around m. leprae were observed. one borderline case was negative. lysozyme of epithelioid cells and giant cells of 10 tuberculoid types were completely negative. these results suggest that lysozyme plays only a small ... | 1978 | 367053 |
| aeration, temperature and presence of glycerol modifying the multiplication of mycobacterium leprae. | the multiplication of 8 strains of m. leprae on medium nm6 + dopa, described by olitzki (1976) in this journal, was enhanced by maximal aeration, by the presence of 1.0% glycerol and by an optimal incubation temperature of 30 degrees c as compared with 37 degrees c. it took place in the presence of several organic acids and n-acetyl-glucosamine. | 1978 | 367388 |
| lymphocyte response of leprosy patients to human-derived and purified armadillo-derived mycobacterium leprae, bcg and ppd. | the lymphocyte transformation test was applied to compare in vitro lymphocyte responses of tuberculoid (high resistant) and lepromatous (low resistant) leprosy patients to purified mycobacterium leprae derived from experimentally infected armadillos and crude m. leprae derived from man, as well as to bacille calmette-guérin (bcg) and purified protein derivative (ppd). it was found that the purification procedure using enzymic digestion did not affect the immunogenicity of armadillo-derived m. le ... | 1978 | 367652 |
| the nasal excretion of leprosy bacilli. | 1978 | 368474 | |
| a day in the life yeeranna--a cautionary tale. | 1978 | 368475 | |
| evaluation of the activity of streptomycin on mycobacterium leprae in mice. | 1978 | 368476 | |
| the clayton memorial lecture, 1978: "is immunoprophylaxis in leprosy feasible?". | 1978 | 368477 | |
| circulating complexes in leprosy studied by the platelet aggregation test. the platelet aggregation test and its relation to the rubino test and other sero-immunological parameters in 135 patients with leprosy. | 1978 | 369750 | |
| [problems concerning mycobacterium leprae and mycobacterium lepraemurium cultures]. | 1978 | 361997 | |
| immunological aspects of leprosy--present status. | 1978 | 362429 | |
| a statistical analysis of two chemotherapy trials in lepromatous leprosy. i. the response to therapy as measured by inoculation of mice. | 1978 | 362950 | |
| a statistical analysis of two chemotherapy trials in lepromatous leprosy. ii. interactions among patient variables. | interrelationships among six patient characteristics recorded upon entry into the trial were analyzed for 67 patients with lepromatous and near-lepromatous leprosy admitted into two chemotherapy trials. sex was found to be significantly associated with age and with the histopathologic classification; disproportionately large numbers of older patients and of patients classified as borderline-lepromatous (bl) were males. classifications of the disease process by clinical and histopathologic criter ... | 1978 | 362951 |
| electron microscopy of peroxidase and acid phosphatase in leprous and uninfected armadillo macrophages: a macrophage subpopulation contains peroxisomes and lacks bacilli. | lepromatous tissue from armadillos inoculated 24--36 months earlier with mycobacterium leprae was obtained for electron microscopic studies. cytochemically stained lepromas revealed a subpopulation of macrophages containing peroxisomes. these peroxidase reactive macrophages were not infected with bacilli. acid phosphatase was present in macrophages and many of these were infected with bacilli and contained vacuoles and lipid globules. within the membrane-bound vacuoles, acid phosphatase surround ... | 1978 | 362952 |
| formation of antibody against mycobacterium leprae antigen 7 in armadillos. | a radioimmunoassay developed to measure antibody against mycobacterium leprae antigen 7 in man was applied to the nine-banded armadillo (dasypus novemcinctus). normal armadillo sera had low but significant antibody activity in the test. fourteen of 17 armadillos with systemic mycobacterial infection after inoculation with m. leprae showed increased antibody activity in the assay, and in some instances the activity was higher than in a pool of sera from patients with lepromatous leprosy. crossed ... | 1978 | 364069 |
| heat stability of mycobacterium leprae immunogenicity. | the protection provided to mice by vaccines administered intradermally was measured after footpad challenge with mycobacterium leprae. the protection offered by m. leprae suspensions was not decreased when the vaccines were killed by 60 degrees c heat or at the higher temperatures tested, which included 215 degrees c (autoclave). even highly purified suspensions retained their immunogenicity. in contrast, the vaccine protection provided by intradermal m. bovis (strain bcg) was markedly reduced w ... | 1978 | 365752 |
| gerhard henrik armauer hansen 1841-1912. the discoverer of the leprosy bacillus. his life and his work. | 1978 | 365786 | |
| effect of specific vaccine on cell-mediated immunity of armadillos against m. leprae. | 1978 | 365788 | |
| electron microscopic observations of intracytoplasmic membranous structures in mycobacterium leprae by means of serial ultrathin sectioning. | the fine structures and interconnections between the cytoplasmic membrane and mesosomes of mycobacterium leprae in human skin were studied in ultrathin sections. these intracellular membranous organelles were seen as laminated structures and as clusters of vesicles, which were trilaminar consisting of two electron-dense layers separated by an electron-transparent zone. the formation of mesosomes seems to be initiated by invagination and/or folding of the cytoplasmic membrane. | 1978 | 365790 |
| culture of hansen's bacilli in vitro in a case of lepromatous leprosy. | 1978 | 347183 | |
| antibody activity against mycobacterium leprae antigen 7 during the first year of dds treatment in lepromatous (bl-ll) leprosy. | 1978 | 347205 |