Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| single versus multiple human-equivalent doses of c. parvum in mice: neutralization of the anti-metastatic effect. | the murine dose of i.v. c. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. all treatments increased the antibody titre against c. parvum (cp). however, repeated doses stimulated a much higher titre than single doses. in all treated animals spleen weight peaked at 2 weeks and then fell. a single low dose caused a 3-fold increase, a single high dose or multiple low doses a 6-fold increase. liver weight changes follow ... | 1980 | 7387830 |
| harmful effects of i.v. corynebacterium parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus. | the effects are reported of a combination therapy of i.v. c. parvum and cyclophosphamide on the survival time and immune responses of patients with inoperable squamous-cell carcinoma of the bronchus. the immune status of the patients was evaluated by determining the antibody response to c. parvum, the e and eac rosettes, the pha response of blood lymphocytes, the skin-test reactivity to candida and ppd, the response to dncb and the chemotaxis and nbt-dye reduction capacity of neutrophil leucocyt ... | 1980 | 7387858 |
| facial follicular porphyrin fluorescence: correlation with age and density of propionibacterium acnes. | the incidence and distribution of facial follicular porphyrin fluorescence was studied in a large group of subjects ranging in age from 1 to 90 years. fluorescence appears first on the nose and chin, increases in incidence through adulthood and declines after the age of 50 possibly rflecting the ras population and confirmed that coproporphyrin iii is proed in vivo. | 1980 | 7387886 |
| treatment of cancer using corynebacterium parvum: similarity of two preparations in four animal tumor models. | the tumor inhibitory properties of corynebacterium parvum obtained from burroughs wellcome (cp-bw) or from institut merieux (cp-im) were compared in four animal tumor models: the cad2 mouse mammary carcinoma treated by intravenous (i.v.) or intratumoral (i.t.) injection of c. parvum; 13762a rat mammary adenocarcinoma treated by i.t. injection of c. parvum either alone or combined with excision of the primary tumor; lstra murine leukemia and line 10 cavian hepatoma, each treated with vaccines con ... | 1980 | 7397633 |
| macrophage heterogeneity in tumor resistance: cytostatic and cytotoxic activity of corynebacterium parvum-activated and proteose peptone-elicited rat macrophages against moloney sarcoma tumor cells. | 1980 | 7397781 | |
| growth and treatment of b 16 melanoma in hyperglycemic mice. | melanoma b-16 grew slowly in mice with hyperglycemia induced by alloxan, glucagon, or glucose. the mechanism of retarded tumor growth is different and depends on the origin of hyperglycemia. the concentration of immunoreactive insulin in blood of mice with melanoma and in the tumor tissue is increased in nondiabetic as well as in diabetic mice. the chemotherapy of melanoma in diabetic mice is as effective as in nondiabetic mice whereas immunotherapy in diabetic mice is not effective. combined ch ... | 1980 | 7403688 |
| aerobic and anaerobic bacteriology of cervical adenitis in children. | needle aspirates from 53 inflamed cervical lymph glands were studies for aerobic and anaerobic bacteria and mycobacteria. bacterial growth was achieved in 45 patients (85%). sixty-six bacterial isolates were recovered, averaging 1.5 isolates per specimen (0.8 aerobes and 0.7 anaerobes), with as many as 4 isolates in some specimens. aerobic organisms alone were recovered in 27 aspirates (60%) of the 45 culture-positive aspirates, anaerobic bacteria alone in 8 (18%), and mixed aerobic and anaerobi ... | 1980 | 7408372 |
| glucagon suppressed proliferation rate of mammary aplastic carcinoma in mice. | glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in corynebacterium parvum pretreated animals. it follows that the tumor-retarding effect of glucagon are mediated by mainly by maintaining high b-type reactivity a ... | 1980 | 7409736 |
| the use of immunotherapy to enhance tumor rejection immunity in leukemic (l2c) guinea pigs following remission induction with meccnu. | 1980 | 7412356 | |
| anti-t antibody in malignant melanoma patients. influence of response and survival following chemotherapy--changes in serum levels following c parvum, bcg immunization. | the level of anti-t antibodies directed towards the precursor t antigen of the mn blood group system was measured in the sera of 55 patients with disseminated melanoma, before and during chemoimmunotherapy. the anti-t titer was subnormal in patients before therapy; patients who responded to therapy had significantly higher titers than did nonresponders in sera taken before therapy, at regression/progression of disease, and during the last pulse of treatment. higher pretreatment titers were assoc ... | 1980 | 7417939 |
| purification and partial characterization of an acid phosphatase (ec 3.1.3.2) produced by propionibacterium acnes. | a strain of propionibacterium acnes (type i; marples & mcginley, 1974), isolated from a blackhead acne lesion, produced an acid phosphatase which was present in the culture supernatant in the late-exponential and early-stationary phases of growth. this acid phosphatase was purified more than 45 000-fold (4.5% yeild). the purified enzyme gave two protein bands on sodium dodecyl sulphate-polyacrylamide gel electrophoresis corresponding to molecular weights of 155 000 and 87 100. the enzyme had a s ... | 1980 | 7420057 |
| effect of three strains of propionibacteria (p. granulosum, p. avidum, p. acnes) and cell-wall preparations on lymphocytes and macrophages. | the effect of the strains of propionibacteria (p. granulosum, p. avidum, p. acnes) on functional and metabolic activities of mouse lymphocytes and rabbit macrophages was examined in vivo and in vitro. in some of the experiments bacterial cell walls isolated from the above bacteria were tested and compared with the activity of whole bacteria. in isolated lymph-node lymphocytes influx of 86rb and its inhibition by ouabaine, release of 86rb and 51cr from prelabelled cells, as well as spontaneous an ... | 1980 | 7424239 |
| effect of intravenous corynebacterium parvum on peripheral-blood effector cells of cancer patients. | the i.v. administration of corynebacterium parvum (cp) to patients who had recently undergone resection of colorectal tumours was found to have the following effects: 1. polymorphonuclear leucocyte counts were raised 24 h after cp administration, while both lymphocyte and monocyte counts fell during this period. polymorph and lymphocyte counts had returned to pre-infusion levels at one week, but monocyte counts were significantly increased at this time. 2. the lymphocyte mitotic response to pha ... | 1980 | 7426303 |
| characterization of serum-independent polymorphonuclear leukocyte chemotactic factors produced by propionibacterium acnes. | the size and production of polymorphonuclear leukocyte (pmn) chemotactic factors by propionibacterium acnes has been studied. all eight strains of p. acnes which were tested liberated pmn chemotactic factors in their growth culture media. the factor(s) produced by one strain, 6919, were studied in greater depth. the pmn response was proportional to the dose of culture supernatant and chemotactic activity increased with the duration of p. acnes culture. the neutrophil migration towards culture su ... | 1980 | 7429606 |
| recovery of hemopoiesis in lethally irradiated mice after treatment with propionibacteria. | three investigated strains of propionibacteria (p. acnes, p. granulosum and p. avidum) injected intraperitoneally in doses of 1.5 mg per mouse, significantly prolonged survival of lethally (8.50 r) irradiated mice. p. granulosum, being the most effective in increasing survival of irradiated mice was chosen for the studies on the activity of bone-marrow pluripotent stem cells. the number of endogenous spleen colonies was significantly increased in mice injected with p. granulosum 3 days prior to ... | 1980 | 7434382 |
| anaerobic bacteremia in children. | twenty-nine anaerobic isolates were recovered from 28 pediatric patients with anaerobic bacteremia: 14 bacteroides sp (11 in the b fragilis group); four anaerobic gram-positive cocci; four clostridium sp; four propionibacterium acnes; and three fusobacterium sp. no aerobic bacteria were isolated from these patients. the gastrointestinal tract was the possible portal of entry in 13 instances, eight of which were due to bacteroides organisms, four to clostridium sp, and one to f nucleatum. the ear ... | 1980 | 7435464 |
| an analysis of sebum excretion rate, bacterial population and the production rate of free fatty acids on human skin. | bacteria were sampled using a "scrub" technique from the skin surface of the faces of forty-nine female subjects aged 18-21 years. the sebum excretion rate was determined by a gravimetric method and the level of free fatty acids by titration. the production rate of free fatty acids was calculated from the product of the concentration of free fatty acids in the sebum and the sebum excretion rate. the date was analysed using kendall's rank correlation method. positive correlations existed between ... | 1980 | 7437304 |
| antitumor activity of corynebacterium parvum and retinyl palmitate used in combination on the lewis lung carcinoma. | the effects of corynebacterium parvum and retinyl palmitate given at various levels, schedules, and routes of administration on primary lewis lung carcinoma and its metastases have been evaluated in c57bl/6j mice given s.c. inoculations of 5 x 10(5) tumor cells. single i.v., but not i.p., s.c., or i.m., administration of c. parvum (0.35 mg/mouse given on days 0, 1, or 3) reduced growth of tumor and prolonged survival time. retinyl palmitate (3000 iu/mouse/day) given alone i.p. either before, aft ... | 1980 | 7438095 |
| effect of corynebacterium parvum stimulation on granulopoiesis. | 1980 | 7439223 | |
| structure and function of human effusion macrophages from patients with malignant and benign disease. 2. in vitro cytostatic and cytolytic effect on human tumour cell lines. | human effusion macrophages isolated from the pleural or ascitic effusions of 14 patients with malignant or benign disease usually inhibited methyl-3h-thymidine incorporation in an adherent human tumour cell line (nhik 3025) when the macrophages were challenged with target cells immediately after isolation. the cytostatic activity disappeared when the macrophages were cultured for 18 hours in vitro before target cell challenge. the presence of endotoxin (lps) or corynebacterium parvum (cp) during ... | 1980 | 7446129 |
| in vitro response to corynebacterium parvum of human effusion lymphocytes isolated from patients with malignant and benign disease. | non-adherent effusion cells (ec), mostly lymphocytes, were isolated from the pleural effusions of 8 patients with malignant and 7 patients with benign disease. corynebacterium parvum (cp) induced increased methyl-3h-thymidine (methyl-3h-tdr) incorporation in ec cultures, but the response was lower than that usually found with autologous or allogeneic normal human blood lymphocytes. experiments with highly purified effusion lymphocytes indicated that the response to cp was influenced by the prese ... | 1980 | 7446130 |
| endocarditis due to propionibacterium acnes. | a case of propionibacterium acnes endocarditis documented by blood culture and culture of the valve is presented. a brief review of the literature is summarized. | 1980 | 7446476 |
| enhancement of the antitumor-activity of corynebacterium parvum by appropriate adjustment of dosage schedules. | single and multiple doses of corynebacterium parvum ranging from 0.01 to 60 mg/kg as the total dose were tested at selected times against 10(6) p388 leukemia cells inoculated ip in bdf1 mice. the minimum dose needed for maximum protection was determined according to the ability of the treatment to produce an increase in the lifespan (ils) of mice. the ip dose required after transplant for significant ils was 40 mg/kg as the total dose. the administration of a single dose 2 days prior to implant ... | 1980 | 7448829 |
| a modified spectrophotometric test for nitroblue-tetrazolium reduction of granulocytes and monocytes and its application for testing inhibition of monocytes by serum components in tumor patients. | for evaluation of serum-factor involvement in monocyte function, we established a modified quantitative spectrophotometric-nitroblue tetrazolium (nbt) test. we investigated the stimulation of human peripheral monocytes and granulocytes by zymosan, endotoxin, and corynebacterium parvum in vitro. in addition, polymorphonuclear neutrophil (pmn) function in a patient with non-hodgkin lymphoma was studied during the course of polychemotherapy and intravenous application of corynebacterium parvum (c. ... | 1980 | 7450815 |
| optimal conditions for antitumor activity of c. parvum against the ascites form of sarcoma 180. | single and multiple doses of corynebacterium parvum (c. parvum) ranging from 0.1--60 mg/kg were tested for antitumor activity against 10(6) sarcoma 180 cells in male cd1 mice. determinations were made of the optimal dose and time of treatment needed to produce maximum suppression of the tumor using both median survival time and percent survival to day 90 as endpoints. a dose of 1 mg/kg given 3 days before sarcoma 180 transplant produced complete protection (100% survival). all other treatment re ... | 1980 | 7452006 |
| [pathology caused by anaerobic bacteria in pediatrics. our cases]. | 1980 | 7453681 | |
| anaerobic bacterial coxitis and pseudocystic tumour in rheumatoid arthritis. a case report. | when patients with rheumatoid arthritis develop rapidly growing tumours around the hip or elbow joint, the possibility should be considered that this condition could be pseudocystic with a low virulent infection. the present report describes such a case of anaerobic bacterial coxitis with rapidly growing tumour. | 1980 | 7455634 |
| regional variations in density of cutaneous propionibacteria: correlation of propionibacterium acnes populations with sebaceous secretion. | cutaneous propionibacterium acnes populations were quantitatively measured in 33 young adults and compared with the rate and composition of sebum secretion in nine skin regions. bacteriological and lipid analyses were performed on the forehead, cheek, anterior chest, abdomen, lower back, volar forearm, upper inner arm, thigh, and calf. p. acnes populations in these sites correlated significantly with the total amount of lipid produced (r = 0.77) as well as with di- and triglycerides (r = 0.68), ... | 1980 | 7276142 |
| preventive effect of propionibacterium acnes on metastasis in mice rendered tolerant to tumor-associated transplantation antigens. | the present study was carried out to investigate the preventive effect of propionibacterium acnes (p. acnes) on metastasis formation of c3h/he mice which has been rendered tolerant to tumor-associated transplantation antigen (tata) of syngeneic x5563 plasmacytoma. c3h/he mice inoculated intravenously (iv) with 10(6) 7000 r x-irradiated x5563 tumor cells 3 times at 4-day intervals. these pretreated mice could not develop immune resistance against x5563 tumor even after the appropriate immunizatio ... | 1980 | 7248045 |
| some "pharmacologic' data about corynebacterium parvum. | 1980 | 7232843 | |
| fermentation of 1,2-o-iso-propylidene-d-glucofuranose ("monoacetone glucose") by anaerobic bacteria. | various species of clostridium, bacteroides, propionibacterium and eubacterium were incubated in a 1% solution of 1,2-o-iso-propylidene-d-glucofuranose in a peptone-yeast-extract (py) medium according to the vpi-technique. the volatile and non volatile acids were investigated by gas-liquid chromatography. all microorganisms showed a pattern of vfa different from that one produced by the glucose containing medium. in most microorganisms the formation of acetic acid was suppressed while the produc ... | 1980 | 7456850 |
| [comparison of two nonspecific immune stimuli in antiblastic chemotherapy]. | antiblastic chemotherapy was combined with two aspecific immune stimuli, levamisole corynebacterium parvum, in 48 and 55 neoplastic patients respectively. c. parvum was found to be more easy to handle, particularly since levamisole, albeit compensated by absolute lymphocytosis in many cases. in addition, c. parvum proved more effective in patients with lung and oro-pharyngeal neoplasias, whereas levamisole appeared to be of greater use in breast cancer. both stimuli led to improved coenaesthesia ... | 1980 | 7458652 |
| the antitumour activity of maltose tetrapalmitate compared with other immunoadjuvants, and its effectiveness after tumour surgery. | the effectivenss of maltose tetrapalmitate (mtp) as an antitumour immune adjuvant was verified by its comparison with other known immunopotentiators, namely bcg, corynebacterium parvum, levamisole and pyran copolymer. copenhagen x fisher 344/crbl f1 hybrid male rats inoculated s.c. with the dunning r3327a prostatic adenocarcinoma were used as the test system. all animals treated with immunoadjuvants showed a delay in tumour appearance and inhibition of early tumour growth. mtp was found to be th ... | 1980 | 7459208 |
| the correlation of susceptibility of different propionibacterium strains to macrophage killing and antitumor activity. | the stimulation of the reticuloendothelial system and antitumor activity against sarcoma-l-1 of three different strains of propionibacterium was investigated. the bacteria injected intraperitoneally with a single dose of 1 mg per mouse appeared to possess different effectiveness in both assays used. the same strains were examined for their susceptibility to phagocytosis and intracellular killing by murine peritoneal macrophages. the results obtained showed correlations between propionibacterium ... | 1980 | 7464684 |
| new medium for isolating propionibacteria and its application to assay of normal flora of human facial skin. | the conditions for isolation and cultivation of propionibacterium acnes and related propionibacteria were studied in detail. triton x-100 added to the diluent inhibited the growth of propionibacteria in concentrations of 0.05 to 0.1%. however, such was not the case with tween 80; rather, growth of the bacteria was further enhanced by this agent. consequently, tween 80 was considered to be a suitable surfactant for addition to the diluent for isolation of propionibacteria. a new medium for isolat ... | 1980 | 7470244 |
| macrophage functions in beige (chédiak-higashi syndrome) mice. | beige (c57bl/6j-bgj/bgj) mice are the murine counterpart of the chédiak-higashi syndrome, exhibiting abnormal lysosomes in phagocytes. these mice, however, responded normally to corynebacterium parvum killed bacterial vaccine with splenomegaly and an increase in peritoneal macrophages. the c. parvum-elicited macrophages showed normal immunoglobulin g fc- and c3b-mediated rosettes and phagocytosis. the antitumor action of the macrophages was assessed against the lewis lung carcinoma, a tumor that ... | 1980 | 7471044 |
| comparative effects of different strains of corynebacterium parvum on natural cell-mediated cytotoxicity. | because there are conflicting reports regarding the effects of corynebacterium parvum (cp) on natural killer (nk) cell activity, several different strains of cp were compared. in replicate experiments, age- and sex-matched mice received 0.25-mg i.p. injections of one of four types of cp; formalin-killed strain 6134; heat-killed strain 6134; formalin-killed strain 5888 (actually corynebacterium granulosum); or formalin-killed cp from the pasteur institute. at various days thereafter, two to three ... | 1980 | 7471057 |
| augmentation of tumoricidal activity of human monocytes and macrophages by lymphokines. | monocytes were separated from peripheral blood mononuclear cells of normal human donors by adherence on plastic conditioned by cell lines (microexudate-coated plastic) and harvested by exposure to ethylene diamine tetra-acetic acid. cytolytic activity was tested by incubating effector cells for 48 h with the murine sv40-transformed tu5 kidney line or the human lung cancer-derived calu line prelabelled with tritiated thymidine. lymphokine-containing supernatants were obtained from in vitroculture ... | 1980 | 14768696 |
| effects of corynebacterium parvum on cellular immunity of cancer patients, assayed sequentially over 63 days. | the immunologic effects of corynebacterium parvum (2 mg/m2) infused at three-week intervals were determined by 19 sequential assays in each of nine patients with metastatic malignancy. peripheral blood immunologic profiles were followed for 63 days. no statistical significant changes (p greater than 0.05) occurred in total white cell, lymphocyte, or monocyte counts. subpopulation assays demonstrated significant increases in e rosetting cells but not in sig-bearing cells; there was a correspondin ... | 1981 | 7459817 |
| immunomodulation by corynebacterium parvum in two strains of guinea-pigs and the effect of cyclophosphamide. | an early immunosuppressive phase in the overall stimulatory effect of corynebacterium parvum on the immune response of two strains of guinea-pigs to ovalbumin (oa) is described. boosters given soon after treatment with c. parvum elicited lower secondary responses than those given later on, the peak secondary antibody titre increasing with the interval between primary immunization and the booster injection. transfer of blood leukocytes (lymphocytes) of immunized donors to virgin syngeneic recipie ... | 1981 | 7461727 |
| propionibacterium acnes central nervous system shunt infection. commercial blood culture medium-dependent isolation of the bacterium. | a 58-year-old woman had a central nervous system shunt infection and septicemia caused by propionibacterium acnes. during a two-year period, many becton-dickinson blood cultures (18 of 39) were positive for p. acnes, but all bactec blood cultures (15) were negative. parallel cultures in the two commercial media performed simultaneously on the same blood samples several times resulted in a positive becton-dickinson culture and a negative bactec culture. this case reemphasizes that some bacterial ... | 1981 | 7234759 |
| effects of the landschütz ascites carcinoma and ascitic fluid on macrophage activity in c. parvum-injected mice. | i.p. administration of 1.4 mg corynebacterium parvum (c. parvum) 24 h before inoculation of landschütz ascites carcinoma (lac) cells significantly impaired growth of the tumour in mf1 mice. the injection of tumour cells caused a transient inhibition of the activity of the mononuclear phagocyte system (mps) in both normal and c. parvum-treated hosts, as evidenced by impaired clearance of colloidal carbon from the bloodstream and reduction in hepatic phagocytosis of 51cr-labelled sheep erythrocyte ... | 1981 | 7236491 |
| coumarin or warfarin treatment of mice does not increase the microbicidal or tumoricidal capacities of macrophages. | benzopyrones have been shown to affect several functions of macrophages. we examined the effects of two benzopyrones, coumarin and warfarin, on the capacity of mouse macrophages to inhibit microorganisms and tumour target cells. mice were treated with daily i.v. doses of either drug. then the mice were challenged with lethal doses of toxoplasma gondii or peritoneal macrophages from these mice were challenged in vitro with t. gondii or tumour target cells survival of coumarin or warfarin-treated ... | 1981 | 7236495 |
| augmentation of natural killer cell activity in spleens of infant, aged, and low responder strain mice by corynebacterium parvum. | murine natural killer (nk) cell activity is both age- and strain-dependent. nk activity does not appear in murine spleen cells until three weeks after birth. activity peaks at approximately 10 weeks, decreasing thereafter with mice over one year old showing significantly reduced levels. mice showing low or no nk activity because of age (aged and infant mice, respectively) can be stimulated to show significant levels of nk lysis by i.p. injection of formalin killed corynebacterium parvum (cp). in ... | 1981 | 7238649 |
| prostaglandin-like substances in propionibacterium acnes. v. activity profiles using cascade superfusion bioassay and platelet aggregation. | 1981 | 7238744 | |
| comparison of cytotoxic and microbicidal function of bronchoalveolar and peritoneal macrophages. | studies were carried out with mice to explore in vitro the effector function(s) of macrophages from two different anatomical compartments (peritoneal cavity and lungs). the cytotoxic capacity of macrophages was measured by determining their cytostatic and cytocidal effects on el-4 tumour target cells, and the microbicidal capacity of macrophages was measured by determining their ability to kill or inhibit the intracellular protozoan, toxoplasma gondii. neither peritoneal macrophages (pm) nor bro ... | 1981 | 7239556 |
| corynebacterium parvum treatment of p388 tumor-bearing mice. i. lysosomal enzyme levels in adherent peritoneal cells and peritoneal lavage fluid. | bdf1 mice treated with corynebacterium parvum (c. parvum) 2 days before an implant of 106 p388 leukemic cells had up to an 110% increase in survival time above control; bacillus calmette-guérin (bcg) treatment was ineffective. acid phosphatase and beta-glucuronidase were measured in adherent peritoneal lavage cells and beta-glucuronidase in peritoneal lavage fluid form mice treated with c. parvum or bcg 2 days before the implant of p388 cells. in the presence of the tumor, adherent peritoneal ce ... | 1981 | 7252179 |
| corynebacterium parvum treatment of p388 tumor-bearing mice. ii. lysosomal enzyme levels associated with p388 tumor cells. | the number of tumor cells recovered form the peritoneal cavity of mice administered corynebacterium parvum (c. parvum), bacillus calmette-guérin (bcg) or saline 2 days before tumor implant was assessed on days 1, 2, 3, 5 and 7 following the intraperitoneal (ip) administration of 10(6) p388 leukemic cells. c. parvum-treated mice manifested a significant decrease in the number of tumor cells recovered from the peritoneal cavity on days 3-7, while bcg-treated mice had tumor cell yields comparable t ... | 1981 | 7252180 |
| delayed hypersensitivity reactions vs chemotherapy and immunotherapy responses in women with ovarian adenocarcinoma. | fifty-one previously untreated women with figo stages iii and iv ovarian adenocarcinoma underwent sequential monthly skin testing utilizing keyhole limpet hemocyanian, varidase, mumps, monilia, and a purified protein derivative tuberculin (ppd) prior to each course of systemic chemotherapy (with or without corynebacterium parvum). the purpose of the study was to evaluate the patients' ability to demonstrate a delayed cutaneous hypersensitivity reaction to these sensitizing antigens and response ... | 1981 | 7253658 |
| influence of the "corynebacterium parvum" vaccine and stilbostat on intratesticular development of walker 256 carcinosarcoma in hyper- or hypothyroidized wistar rats. | this work studies the effect of nonspecific antitumoral immunity produced by the "corynebacterium parvum" vaccine (c.p.) and stilbostal on the development of walker 256 carcinosarcoma intratesticularly grafted to hyper- or hypothyroidized wistar rats. the thyroid hormone level was altered by administration of thyroxin, alkiron or surgical thyroidectomy. the c.p. vaccine was given in a mixture with tumoral cells suspension and the treatment with the stilbostat drug was started 5 days from graftin ... | 1981 | 7256164 |
| correlation of propionibacterium acnes populations with the presence of triglycerides on nonhuman skin. | the skins of mice, rats, rabbits, sheep, guinea pigs, and dogs were cultured for propionibacterium acnes. only the sebaceous regions (perianal gland) of guinea pigs harbored a significant p. acnes population. analysis of the lipid from this region revealed a significant percentage of triglycerides, compounds lacking in the sebum of the other animals. | 1981 | 7259157 |
| organ distributions and clearance studies of 99mtechnetium-labeled corynebacterium parvum in patients with leukemia. | the clearance, metabolism and localization of corynebacterium parvum (c. parvum) labeled with 99mtechnetium (99mtc) given intravenously was studied in various leukemia patients to develop the method and to evaluate reticuloendothelial systems (res) function. a computer program was utilized to characterize the clearance. c. parvum 0.05 mg was labeled aseptically with 10 mci of 99mtc with a reducing agent. it was injected intravenously over 5 s and clearance was characterized over the next 60 min. ... | 1981 | 7263121 |
| use of mini-microaggregated albumin to study reticuloendothelial system (res) function in c. parvum-treated animals. | mini-microaggregated albumin colloid (particle size less than 80 a) and microaggregated albumin colloid (particle size 500-1000 a) made from human serum albumin were conjugated with 99mtechnetium and used to study reticuloendothelial system (res) function in animals treated intravenously with c. parvum. the uptake in blood, liver and spleen were studied in untreated mice and in mice at various times after treatment with 150 or 300 micrograms of c. parvum. the blood clearance of these materials w ... | 1981 | 7263122 |
| chemoimmunotherapy (dtic and corynebacterium parvum) for disseminated malignant melanoma. | 1981 | 7273032 | |
| activation of the alternative pathway of complement in human serum by propionibacterium acnes (corynebacterium parvum) cell fractions. | activation of the alternative pathway of complement is known to be initiated by bacterial structures. we have fractionated propionibacterium acnes cells, purified various cell fractions, and tested their complement-activating ability in human serum chelated with ethyleneglycol bis-(beta-aminoethylether)-n,n1-tetraacetic acid. the majority of complement-activating activity was localized in the wall fraction. this activity was resistant to lipid extraction, protease, rnase, dnase and lysozyme trea ... | 1981 | 7275277 |
| immunity to transplantable nitrosourea-induced neurogenic tumors. i. potentiation of tumor immunity with corynebacterium parvum. | various injection schedules of c. parvum and tumor cells of the nitrosourea-induced malignant neurinoma, tr-481, were used to induce tumor immunity in syngeneic cdf rats. although subcutaneous injection of the poorly immunogenic tr-481 cells alone or with c. parvum caused retardation of growth of 2 x 10(5) tr-481 cells injected 1-3 weeks later, no significant difference in tumor size or incidence was obtained, as judged by tumor growth at 8 weeks. in contrast, injection of tr-481 with c. parvum ... | 1981 | 7276992 |
| dtic and actinomycin d with and without c. parvum immunotherapy in advanced malignant melanoma. | 1981 | 7281240 | |
| adriamycin-activated macrophages as tumor growth inhibitors. | flow cytometry has been used to study the influence of adriamycin- and corynebacterium parvum-elicited cytostatic macrophages on the cell cycle of hela cells. macrophages harvested from the peritoneal cavity of mice given i.p. injections of adriamycin retain cytostatic activity for 3 to 4 days in vivo. many of these macrophages fluoresced with the red emission spectra characteristic of adriamycin. the decline in the presence of macrophages exhibiting red fluorescent cytoplasmic particles paralle ... | 1981 | 7284993 |
| morphological and functional aspects of active specific immunotherapy of established pulmonary metastases in guinea pigs. | 1981 | 7285011 | |
| metabolic host reaction in response to the proliferation of nonmalignant cells versus malignant cells in vivo. | 1981 | 7285018 | |
| inhibitory effect of propionibacterium acnes-activated macrophages on the tumor metastasis enhanced by tumor-specific immunosuppression. | the present study deals with the mechanism by which propionibacterium acnes (p. acnes) prevents metastasis formation in c3h/he mice which had been rendered tolerant to tumor-associated transplantation antigen (tata) of syngeneic x5563 plasmacytoma by intravenous (iv) inoculation of 10(6) x-irradiated tumor cells 3 times at 4-day intervals. in these tata-tolerant mice, systemic metastasis formation was enhanced after intradermal (id) implantation of viable tumor cells, even if the tumor was resec ... | 1981 | 7286546 |
| the isolation of a lectin-like molecule from corynebacterium parvum (nctc 10390). | a mannose specific lectin has been isolated by affinity chromatography from the cell wall of c. parvum. polyacrylamide gel electrophoresis indicates that the lectin molecules lie in the molecular weight range 57,000--72,000. it appears that c. parvum like e. coli and salmonellae express lectins that bind to cells expressing mannose in their membranes. this may partly account for the interaction between c. parvum and the macrophage leading to the various immunological phenomena associated with c. ... | 1981 | 7288872 |
| corynebacterium parvum stimulation of adherent and non-adherent cytotoxic cells in mice. | two naturally occurring cytotoxic cell populations have been identified in the peritoneal cavity of mice inoculated with c. parvum (cp), and are distinguishable on the basis of target-cell reactivity and intrinsic properties. the first effector cell was non-adherent to nylon wool and glass and non-phagocytic. these cells were selectively cytotoxic to the nk-sensitive target cell line k562, and present in the peritoneal cavity of mice 2 days after treatment with 700 micrograms of cp. the second c ... | 1981 | 7295509 |
| simple estimation of macrophage activity in tumour-bearing animals treated with corynebacterium parvum. | the effects of corynebacterium parvum on the reticuloendothelial system and on tumour growth have been known for many years. the causes of these effects have been the subject of many hypotheses and we here discuss a new method of evaluating macrophage activity and some of its components. these studies show that in macrophage activation the degree of enzymic activity and the cell size are more important than the number of cells present and that by giving silica concurrently it is macrophage enzym ... | 1981 | 7295527 |
| alterations of host resistance to listeria monocytogenes in tumour-bearing mice and the effect of corynebacterium parvum. | in tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to listeria monocytogenes following tumour growth were examined. non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. on the other hand, t cell-mediated immune resistance retained the control level up to day 7 or so, but was suppressed thereafter. suppression of macrophage-mediated antibacterial resistance was not observed if ... | 1981 | 7298070 |
| late anaerobic haematogenous infection of experimental total joint replacement. a study in the rabbit using propionibacterium acnes. | 1981 | 7298696 | |
| comparative study on the immunostimulatory potency of different propionibacterium strains. | 198 strains of propionibacterium acnes, p. avidum, and p. granulosum were tested for their immunostimulatory potency using splenomegaly as index of stimulation, the activity differed widely from strain to strain. the antitumor and antimetastatic properties of six strains with differing stimulation activities were carefully examined. a close correlation between spleen enlargement and antitumor effects could be observed. the simple spleen enlargement test is recommended for determination of the im ... | 1981 | 7300800 |
| [immunochemotherapeutic treatment of gastrointestinal neoplasms]. | the results obtained with a three-fold association of drugs (vcr, 5fu, meccnu) in the treatment of 68 patients suffering from advanced carcinoma of the gastroenteric system followed up over an approximately four year period at the savona oncology centre are reported. the percentage of positive responses (cr + pr) was 75% for carcinoma of the colon-rectum and 44.4% for stomach cancer. the results obtained in intestinal carcinoma proved more satisfactory than those reported in the literature. this ... | 1981 | 7301183 |
| intrasplenic abscess: two case reports and review of the literature. | the occurrence of splenic abscess, sickle cell trait, and drug addiction is described in two patients. the coincidence of sickle cell disease and drug addiction in the possible etiology of splenic abscess should be noted. the first patient had a splenic abscess in the inferior pole of the spleen with signs and symptoms of left upper quadrant peritoneal irritation. the second patient had an intrasplenic abscess in the superior pole with pleuritic type chest pain and large left pleural effusion. i ... | 1981 | 7305137 |
| evaluation of intratumoral immunostimulants in the treatment of a transplantable rat mammary carcinoma. | 1981 | 7308253 | |
| adjuvant therapy for malignant melanoma. | 1981 | 7313933 | |
| antimetastatic effect of cell-wall skeleton of propionibacterium acnes c7 on lewis lung carcinoma in c57bl/6j mice. | the effect of the cell-wall skeleton (cws) of propionibacterium acnes c7 on the metastasis of lewis lung carcinoma in c57bl/6j mice was examined. intratumoral or intravenous injection of p. acnes-cws was effective for both prolongation of the survival period and protection against pulmonary metastases, but intraperitoneal injection was ineffective in tumor-bearing mice. intratumoral injection of p. acnes-cws also inhibited lymph node metastases and produced some complete tumor regressions. these ... | 1981 | 7319198 |
| effect of intracerebral administration of corynebacterium parvum on the growth of brain tumors in mice. | the effect of intracerebral administration of corynebacterium parvum (c. parvum) on the growth of syngeneic brain tumors in c57bl/6 mice and the mechanism of its action were investigated. mice were inoculated with 10(4) malignant glioma cells intracerebrally, and treated with various doses of c parvum on day 6 after tumor inoculation. the growth of tumors was significantly inhibited in proportion ot the dose of c. parvum. the cytotoxic activity of effector cells was enhanced when c. parvum was a ... | 1981 | 7319201 |
| resistance to cutaneous leishmaniasis in genetically susceptible balb/c mice. | when injected cutaneously with promastigotes of an isolate of leishmania tropica, balb/c mice develop progressive cutaneous disease whereas lesions in balb/c.h-2k mice heal after several weeks. lesions in balb/c mice injected into deep subcutaneous tissues with promastigotes are less obvious early but much more prominent later than in mice after strict intradermal injection. balb/c mice injected with corynebacterium parvum together with a preparation of frozen and thawed infected macrophages are ... | 1981 | 7325887 |
| differential sensitivity of two murine leukaemia sublines to cytolysis by corynebacterium parvum-activated macrophages. | we observed the growth of 2 sublines of leukaemia l1210 in histocompatible dba2 mice given 10(3) cells i.p. and studied the protective effect of corynebacterium parvum (cp). the growth of subline l1210-m was unaffected by pretreatment with cp or admixture with 10(5) peritoneal cells (pc) from cp-treated mice. in contrast, the growth of subline l1210-c was inhibited; cp pretreatment increased the proportion of long-term survivors (70% vs 20%) and admixture with cp-pc prolonged the survival time ( ... | 1981 | 7326193 |
| lower relapse rates after neighbourhood injection of corynebacterium parvum in operable cervix carcinoma. | the effect of adjuvant immunotherapy with a single neighbourhood injection of 2 mg c. parvum (cp) was investigated in a randomized study involving 43 patients with carcinoma of the cervix uteri, all of whom were treated by radical surgery. all patients had carcinoma confined to the cervix, the upper part of the vagina or the parametrial region. when the malignancy had spread to the parametrial region, additional postoperative radiotherapy was given. 22 patients received immunotherapy 10 days bef ... | 1981 | 7326194 |
| prostaglandin-like substances in propionibacterium acnes. vi. characterization of the lipid fraction by gas chromatography in conjunction with mass spectrometry. | the lipid fraction of p. acnes was submitted to stepwise purification followed by bioassay in order to localize the prostaglandin-like material. gc-ms analysis revealed the occurrence of substances having a part but not a total molecule in common with the prostaglandin family, suggesting that prostaglandin-like substances represent a new group of prostaglandin compounds. | 1981 | 7327228 |
| enhanced resistance of mice to mycoplasma pulmonis-induced arthritis by administration of killed corynebacterium parvum. | inoculation of mice with corynebacterium parvum 14 days before intraperitoneal inoculation of mycoplasma pulmonis resulted in arthritis of significantly lesser magnitude than in control mice as measured both clinically and histologically. mycoplasmas were isolated from the joints of mice inoculated with c. parvum less frequently than from control mice when the arthritis was maximal. mycoplasmas were also isolated in smaller numbers from the blood and joints of mice pretreated with c. parvum with ... | 1981 | 7337973 |
| depression of hepatic biotransformations by chemical immunoadjuvants. | administration of bcg and corynebacterium parvum is known to cause depression of the hepatic microsomal enzyme system (hmes) in mice. in the present study we explored the effects on hmes of two chemical immunoadjuvants, one of which (pyran copolymer) with peculiarly long-lasting biological activities. the two synthetic immunoadjuvants proved to be potent hmes inhibitors and, for pyran copolymer, peak levels of inhibition concurred with maximal macrophage activation. the inhibition was largely do ... | 1981 | 7338632 |
| research on the production site of tumor necrosis factor (tnf). | tumor necrosis factor (tnf) is an active component of serum taken from corynebacterium parvum (c. parvum) infected mice treated with lipopolysaccharide (lps). to locate the production site of tnf, we tried to block tnf production by using the following reagents; carrageenan, hydrocortisone, and trypan blue. following the injection of a large dose of carrageenan, administered before c. parvum treatment, tnf production was completely blocked. however, when administered after c. parvum treatment bu ... | 1981 | 7339069 |
| [the mechanism of immunosuppression in tumor-bearing mice--different susceptibility of various immune responses to immunosuppression and macrophage series as targets for immunosuppression (author's transl)]. | 1981 | 7341394 | |
| effects of glucose concentration n biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | there cutaneous propionibacteria - propionibacterium acnes, p. avidum and p. granulosum - were grown in chemostats using semi-synthetic medium with various concentrations of glucose. biomass rose with increasing glucose concentration up to 0.3-0.4% (w/v) and then remained constant. propionibacterium granulosum had both a low yield and low mumax when grown in the absence of glucose suggesting that this organism is essentially 'saccharolytic' in its nutrition. in contrast, p. acnes and p. avidum h ... | 1981 | 7343643 |
| early changes in the radiosensitivity of corynebacterium parvum-stimulated cfu-s. | corynebacterium parvum injected intraperitoneally into c57bl mice induced a progression of hemopoietic cfu-s of c57bl mice from the resting state immediately after, and in the early period (approximately 8 h) after stimulation. dose-response survival curves of the stimulated endogenous spleen cfu-s after the c. parvum injection revealed changing slopes or d0 of dose-response survival curves indicative of changing sensitivity states. shortly after stimulation, the cells were sensitive to high spe ... | 1981 | 7348462 |
| improved survival in severely burned animals using intravenous corynebacterium parvum vaccine post injury. | this study was designed to determine the potential benefit or toxicity of an immunomodulator, corynebacterium parvum vaccine, when it is given after severe burn injury. forty conditioned beagles received a 33% total body surface 3-degree flame burn and were resuscitated with ringer's lactate solution (3 ml/kg/% burn). wounds were treated daily for 10 days with silver sulfadiazine cream. two days and nine days after burn, 21 of the animals received c. parvum vaccine (10 mg/kg iv) in a saline infu ... | 1981 | 7455909 |
| serum zinc levels in lung cancer patients. | serum zinc concentrations were determined in 26 extensive squamous cell lung cancer patients and were tested for correlations with survival, response to therapy, nutritional status indices, and various host defense characteristics. subnormal serum zinc levels were found in 24 of the 26 patients. the mean serum zinc concentration was 43.2/micrograms 100 ml +/- 3.6 s.e.m. (normal = 80-100 micrograms/100 ml). a significant (p = 0.007) survival advantage was demonstrated for those patients with pret ... | 1981 | 7226079 |
| potentiation of macrophage tumor cytostasis by tumor-induced ascites. | 1981 | 7229369 | |
| prostaglandin formation in bacteria : a reevaluation. | we report here that production and release of pge2 do not occur in common bacteria. the apparent production in the presence of arachidonic acid, previously reported (1) may be explained by pge2 contamination and autooxidation of the aa used. the presence of pge2 like material in some but not all isolates of propionibacterium acnes is confirmed. | 1981 | 7232767 |
| propionibacterium acnes infection following subdural tap. | the case of an infant who had subdural hematomas that became infected with propionibacterium acnes is reported. this is the second reported case of intracranial propionibacterium acnes infection resulting from diagnostic or therapeutic manipulation. | 1981 | 7211765 |
| studies on pathogenicity and persistence of propionibacterium acnes in mice. | the pathogenicity of propionibacterium acnes was studied using immunodeficient and germ-free (gf) mice. p. acnes injected i.p. to immunocompetent (ddy and balb/c-nu/+) and -deficient mice (cba/n and balb/c-nu/nu) decreased rapidly and only as small number were recovered from organs from day 7 on. the organisms injected similarly into gf-immunocompetent (gf-cf1) mice also decreased but when injected into gf-immunodeficient (gf-balb/c-nu/nu) mice a small number persisted as late as week 4. when gf ... | 1981 | 7200303 |
| specific and nonspecific immunotherapy as an adjunct to curative surgery for cancer of the lung. | attempts to improve survival following curative surgery for non-small-cell lung cancer are reviewed. most of these approaches have been designed to stimulate the resistance of lung cancer patients in a non-specific fashion. living bacteria or products of dead bacteria have been given as adjunctive treatment. various routes have been used; oral, intradermal, subdermal, or intrapleural, with either bcg or corynebacterium parvum. no reproducible benefit has been observed. levamisole has not been pr ... | 1981 | 7039148 |
| partial purification and characterization of lipase (ec 3.1.1.3) from propionibacterium acnes. | lipase from propionibacterium acnes has been purified 4800-fold from crude culture supernatant. the purified enzyme preparation had no assayable protease, hyaluronate lyase or acid phosphatase activities. the molecular weight of the lipase was 46,770 as determined by gel filtration. sodium dodecyl sulphate-polyacrylamide gel electrophoresis revealed a major protein component (mol. wt 41,190) together with two minor protein components (mol. wt 67,000 and 125,900). the lipase had a ph optimum of 6 ... | 1981 | 7035615 |
| requirements for successful immunotherapy and chemoimmunotherapy of a murine model of ovarian cancer. | a comprehensive study of nonspecific immunotherapy has been conducted in an established murine model of ovarian cancer in order to determine the relative effectiveness of commonly used bacterial immunostimulants, the importance of the route and schedule of administration of these agents, and their effects in combination with chemotherapy. implants of 10(5) or 10(6) ovarian tumor cells i.p. kill all syngeneic c3heb/fej mice within 25 days. corynebacterium parvum (700 microgram/mouse i.p. 24 hr af ... | 1981 | 7193085 |
| surgical adjuvant therapy of malignant melanoma with corynebacterium parvum. | the authors' previous surgical adjuvant trial in patients with malignant melanoma at high risk of recurrence has shown no difference in disease-free interval or survival between patients randomized to surgery + bcg or surgery alone. reported here is a subsequent nonrandomized trial in 30 similar patients who received surgery + corynebacterium parvum (cp) 4 mg i.v. daily x 5, followed by 4 mg s.c. weekly for up to three years. after i.v. c. parvum, chills, fever, headache, and hypertension were c ... | 1981 | 7016302 |
| late infection of total hip arthroplasty with propionibacterium acnes: a case and review of the literature. | a 24-year-old woman had a propionibacterium acnes infection of a total hip arthroplasty. the clinical course of an infection with this organism has been previously described in detail. the radiologic appearance of a well-circumscribed lytic defect in the femoral shaft is also an unusual if not unique presentation of late infection after total hip arthroplasty. moreover, simple excision of this infected nidus coupled with antibiotic therapy achieved a complete clinical recovery, in sharp contrast ... | 1981 | 7018779 |
| trapping and killing of candida albicans by corynebacterium parvum-activated livers. | corynebacterium parvum vaccination significantly increased the number of leukocytes adherent to hepatic vessels. perfused c. parvum-treated livers killed significantly more candida albicans than did livers not treated with c. parvum, an effect reversed by the macrophage inhibitors silica, phenylbutazone, and iodoacetate. | 1981 | 7019084 |
| [anaerobic bacteria in clinical specimens of a hospital laboratory (author's transl)]. | over a 14-month period 261 clinical specimens were cultured anaerobically, this figure representing about 3% of the total specimens submitted to the microbiological laboratory. not accepted for anaerobic culture were stools, sputa, urines, vaginal and urethral swabs and swabs from superficial skin lesions. all materials were sent to the laboratory in an anaerobic transport medium and processed according to the recommendations of the american society for microbiology and the center for disease co ... | 1981 | 7020261 |
| host defenses in murine malaria: nonspecific resistance to plasmodium berghei generated in response to mycobacterium bovis infection or corynebacterium parvum stimulation. | infection with mycobacterium bovis (bcg) or injection of killed corynebacterium parvum protected some strain b6d2 f1 (c57bl/6xdba/2) mice but did not protect strain icr or a mice from lethal challenge with plasmodium berghei strain nyu-2. b6d2 mice were not protected against challenges delivered immediately after intravenous injection of these materials, but rather protection developed by day 7 and persisted through at least day 84. infections in protected mice progressed to about 10% parasitemi ... | 1981 | 7021424 |
| endotoxin-induced serum factor kills malarial parasites in vitro. | we investigated the possibility that malarial parasites may be killed by nonspecific soluble mediators, such as those in tumor necrosis serum, that are obtained from mice given macrophage-activating agents like corynebacterium parvum or mycobacterium bovis bcg, followed by endotoxin. such sera killed parasites in vitro after overnight incubation; killing was measured directly by using an in vivo infectivity assay. parasite infectivity was not decreased by incubation in sera from mice given c. pa ... | 1981 | 7021427 |
| antitumor activity of intralesionally administered nocardia opaca preparations in rat and mouse tumors: a comparison with bcg and corynebacterium parvum. | three nocardia products: delipidated cells, lysozyme digest and nocardia water soluble mitogen (nw sm), have been assayed in regression experiments and compared with living bcg and killed c. parvum in rat and mouse fibrosarcomas transplanted intradermally. intratumor injection of these nocardia products induced regression in the bcg sensitive mcfifi2 (s) tumor. these substances were active at a dose of 1 mg, the lysozyme extract and nw sm also being active at 0.1 mg. association with mineral or ... | 1981 | 7021434 |
| phagocytosis and killing of salmonella typhimurium by peritoneal exudate cells. | normal peritoneal cells from conventional, germfree, or nu/nu mice readily killed opsonized salmonellae, an observation that suggests that this activity in the normal peritoneal cavity may not be dependent on either environmental antigenic stimulation or t-cell mediation. in contrast, peritoneal cells elicited 4 days after injection with thioglycolate medium failed to kill opsonized salmonellae but appeared to be highly phagocytic. peritoneal cells from thioglycolate-treated mice could be induce ... | 1981 | 7024128 |