Publications

in situ activation of syngeneic tumour-specific cytotoxic t lymphocytes: intra-pinna immunization followed by restimulation in the peritoneal cavity.	tumour-specific cytotoxic t lymphocytes (ctl) are usually obtained after immunization in vivo and restimulation of immune cells in vitro. we here describe the generation of syngeneic tumour-specific ctl within no more than 9 days by priming and restimulation in vivo. this is achieved only if the correct sites are used both for primary immunization (ear pinna) and for restimulation (peritoneal cavity). the kinetics of immune t cell induction and of the secondary response in vivo will be reported. ...	2006	1868488
[why do physicians and patients ever more often resort to practitioners of alternative medicine: the healer and the quack?].		2006	1563606
serologic survey of eptesicus fuscus from georgia, u.s.a. for rickettsia and borrelia and laboratory transmission of a rickettsia by bat ticks.	bats and their ectoparasites are associated with bacterial agents of unknown pathogenicity. we tested sera from 56 eptesicus fuscus from georgia against borrelia hermsii, orientia tsutsugamushi, rickettsia conorii, and rickettsia rickettsii. we detected antibodies reactive against a relapsing fever borrelia and spotted fever group rickettsia in 3/56 and 1/56 bats, respectively. we attempted to culture bartonella from the blood of these bats but were unsuccessful. in addition, we fed bat ticks, c ...	2006	17249357
serologic evidence for exposure to rickettsia rickettsii in eastern arizona and recent emergence of rocky mountain spotted fever in this region.	during 2002 through 2004, 15 patients with rocky mountain spotted fever (rmsf) were identified in a rural community in arizona where the disease had not been previously reported. the outbreak was associated with rickettsia rickettsii in an unexpected tick vector, the brown dog tick (rhipicephalus sanguineus), which had not been previously associated with rmsf transmission in the united states. we investigated the extent of exposure to r. rickettsii in the local area through serologic evaluations ...	2006	17187578
rocky mountain spotted fever.		2006	17200577
the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec.	infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ...	2006	17217089
child abuse: does prosecution serve any useful purpose?		2006	1635513
nutrition and head start.		2006	1458961
dopamine agonists and pituitary tumor shrinkage.	the primary aim of this review has been to clarify the tumor shrinking effects of dopamine agonists on pituitary macroadenomas of different cell types. shrinkage is most dramatic for macroprolactinomas and is due to cell size reduction. seventy-nine percent of 271 definite macroprolactinomas were reduced in size by at least 25%, and 89% shrank to some degree. most shrinkage occurs during the first 3 months of treatment, although in a minority shrinkage is delayed. dopamine agonist resistance dur ...	2006	1352243
[false acute abdomen in spontaneous rupture of the rectus abdominis muscle].		2006	1831872
[false acute abdomen in spontaneous rupture of the rectus abdominis muscle].		2006	1831872
[perverse interactions].		2006	1594856
health status of the temporarily homeless population and residents of north west thames region.	to survey the health status of the temporarily homeless population of north west thames region and make comparisons with regional residents.	2006	1392918
epidemiology of respiratory hazards: recent advances.	a bibliographical review of epidemiological studies published over the last five years has led us to individualize the themes that have been the subject of most recent publications (table i). these research themes are not new, which shows a certain continuity in epidemiological research on the respiratory risks of occupational origin. few studies are devoted to the identification of unrecognized respiratory risks; nevertheless, the methodology used, the indicators of effects studies contribute t ...	2006	1626104
the role of an adhesive (histoacryl) in tendon repair.	two in vitro experiments have been done comparing various techniques of tendon repair. these include repairs using an adhesive, 2-butyl cyanoacrylate (histoacryl), and repairs by the modified kessler technique, using 4/0 braided polyester and 4/0 stainless steel. mechanical analysis has shown that by replacing the circumferential suture of a modified kessler tendon repair with histoacryl, the tensile strength of the repair and the force needed to produce a gap can be increased by 30% to 40%. thi ...	2006	1479248
[torsion of the colonic epiploic appendages].	operations were carried out on 21 patients with torsion of epiploic appendages of the colon (sigmoid 19, ascending 1, hepatic flexure 1). this pathologic condition has no specific manifestations and occurs under the mask of other emergencies. the suggested symptom of "pain displacement" in combination with other signs allowed the correct diagnosis to be established before the operation in two thirds of patients. patients with torsion of epiploic appendages must be subjected to an emergency opera ...	2006	1388218
surveyor attachment for milling guiding planes.		2006	1800744
surveyor attachment for milling guiding planes.		2006	1800744
maternal plasma fibronectin and neonatal birth weight.	similar plasma fibrinoectin levels were found in nonpregnant volunteers and first or third trimester normal pregnant women, while in preeclamptics it was two times higher. the close relationship observed between maternal plasma fibronectin content and corrected fetal birth weight suggests that the state of microcirculation has a profound influence on neonatal birth weight.	2006	1559625
traumatic endophthalmitis.		2006	3294703
pharmaceutical promotions.		2006	1435909
percutaneous mitral balloon valvotomy.		2006	1538723
[surgical reperfusion and myocardial revascularization in patients with cardiogenic shock].		2006	1800823
intradermal vaccination against hepatitis b.		2007	2878212
long-term enteral feeding: a retrospective comparison of delivery via percutaneous endoscopic gastrostomy and nasoenteric tubes.	the use of percutaneous endoscopic gastrostomy (peg) tubes for enteral feeding is widespread, although their superiority to other feeding devices, such as nasoenteric tubes (net), has not been substantiated. we retrospectively compared clinical outcomes in patients who received enteral feeding via peg (n = 80) or net (n = 29) from 1984 to 1988. mean follow-up was 192 days in the peg group and 141 days in the net group. changes in nutritional and performance status were similar in both groups. as ...	2007	1951237
pyogenic meningitis and cerebral abscesses after endoscopic injection sclerotherapy.	infectious complications of endoscopic injection sclerotherapy (eis) are rare. we report here a case in which pyogenic meningitis and multiple cerebral abscesses developed after a session of eis. the patient was successfully treated with a combination of parenteral antibiotics and repeated bedside pus aspirations. prophylactic antibiotics may be considered in such situations for subsequent sessions of eis.	2007	1951249
shoulder surgery.		2007	2223442
shoulder surgery.		2007	2223442
contracts for rmos in obstetrics and gynaecology.		2007	1852332
amino acid sequence of crustacean hyperglycemic hormone (chh) from the crayfish, orconectes limosus: emergence of a novel neuropeptide family.	the primary structure of the major form of chh from sinus glands of the crayfish, orconectes limosus, was determined by manual edman microsequencing. it is a 72-residue peptide with a calculated mr of 8400 da. in the number of residues, it is identical to the chh of carcinus maenas and very similar to mih (moult inhibiting hormone) of homarus americanus. all three peptides have pglu as n-terminus in common, and val-nh2 is the c-terminal residue in orconectes and carcinus chh. six cys residues oc ...	2007	1800954
measuring cholesterol. a handbook for out-patient clinics and laboratory personnel.		2007	2100407
intrathoracic lymphadenopathy. a rare manifestation of rheumatoid pulmonary disease.	this is the first antemortem report of a patient with long-standing ra and interstitial lung disease who developed reactive mediastinal adenopathy coincident with increases in the activity of his interstitial process. mediastinal adenopathy was discovered by means of ct of the chest as part of an evaluation of interstitial lung disease. the increasing use of better imaging techniques for this purpose will undoubtedly reveal more patients with this finding. mediastinal lymphadenopathy complicatin ...	2007	2323235
granulocytic sarcoma of the submandibular lymph node preceding overt leukemia: significance of strict evaluation of bone marrow.		2007	1951190
hospital outbreak of scabies stemming from two aids patients with norwegian scabies.		2007	1971073
clinical and laboratory features, hospital course, and outcome of rocky mountain spotted fever in children.	to describe the clinical characteristics and course of children with laboratory-diagnosed rocky mountain spotted fever (rmsf) and to identify clinical findings independently associated with adverse outcomes of death or discharge with neurologic deficits.	2007	17236897
rocky mountain spotted fever.	rocky mountain spotted fever (rmsf) is a life-threatening disease caused by rickettsia rickettsii, an obligately intracellular bacterium that is spread to human beings by ticks. more than a century after its first clinical description, this disease is still among the most virulent human infections identified, being potentially fatal even in previously healthy young people. the diagnosis of rmsf is based on the patient's history and a physical examination, and often presents a dilemma for clinici ...	2007	17961858
surveillance for zoonotic vector-borne infections using sick dogs from southeastern brazil.	for many vector-borne organisms, dogs can be used as sentinels to estimate the risk of human infection. the objective of this study was to use dogs as sentinels for multiple vector-borne organisms in order to evaluate the potential for human infection with these agents in southeastern brazil. blood from 198 sick dogs with clinicopathological abnormalities consistent with tick-borne infections were selected at the são paulo state university veterinary teaching hospital in botucatu and tested for ...	2007	18021025
[fever that should not kill].		2007	18320097
rickettsial infection in capybaras (hydrochoerus hydrochaeris) from são paulo, brazil: serological evidence for infection by rickettsia bellii and rickettsia parkeri.	in brazil, capybaras (hydrochoerus hydrochaeris) are important hosts for amblyomma ticks, which in turn can transmit rickettsiae to humans and animals. therefore, capybaras are potential sentinels for rickettsial infection.	2007	18320102
association between polyarthritis and thrombocytopenia and increased prevalence of vectorborne pathogens in californian dogs.		2007	17277299
detection of rickettsia rickettsii and bartonella henselae in rhipicephalus sanguineus ticks from california.	sixty-two questing adult rhipicephalus sanguineus (latreille) ticks were collected by direct removal from blades of turfgrass and adjacent concrete walkways at a suburban home in riverside county, ca, and tested for the presence of rickettsia, bartonella, and ehrlichia dna. polymerase chain reaction (pcr) was used to amplify fragments of the 17-kda antigen gene and the rompa gene of the spotted fever group rickettsiae. one male tick contained r. rickettsii dna; its genotype differed from r. rick ...	2007	17294935
the ticks (acari: ixodida: argasidae, ixodidae) of paraguay.	the ticks reported in paraguay, which are here reviewed, can be categorized as 'endemic or established' (argas persicus or a sibling species, ornithodoros hasei, o. rostratus, o. rudis, o. talaje/o. puertoricensis, amblyomma aureolatum, am. auricularium, am. brasiliense, am. cajennense, am. calcaratum, am. coelebs, am. dissimile, am. dubitatum, am. incisum, am. longirostre, am. nodosum, am. ovale, am. pacae, am. parvum, am. pseudoconcolor, am. rotundatum, am. scutatum, am. tigrinum, am. triste, ...	2007	17362600
a case of rocky mountain spotted fever.	rocky mountain spotted fever is a serious, generalized infection that is spread to humans through the bite of infected ticks. it can be lethal but it is curable. the disease gets its name from the rocky mountain region where it was first identified in 1896. the fever is caused by the bacterium rickettsia rickettsii and is maintained in nature in a complex life cycle involving ticks and mammals. humans are considered to be accidental hosts and are not involved in the natural transmission cycle of ...	2007	17511369
murine typhus in children, south texas.	children from south texas were evaluated for immunoglobulin g to rickettsia typhi, the causative agent of murine typhus. of 513 children, 8.6% of those 1-5 years of age, 13.3% of those 6-11 years of age, and 13.8% of those 12-17 years of age had positive results.	2007	17553239
molecular typing of isolates of rickettsia rickettsii by use of dna sequencing of variable intergenic regions.	rickettsia rickettsii, the causative agent of rocky mountain spotted fever, is found throughout the americas, where it is associated with different animal reservoirs and tick vectors. no molecular typing system currently exists to allow for the robust differentiation of isolates of r. rickettsii. analysis of eight completed genome sequences of rickettsial species revealed a high degree of sequence conservation within the coding regions of chromosomes in the genus. intergenic regions between codi ...	2007	17553977
prevalence of rickettsia infection in dogs from the urban and rural areas of monte negro municipality, western amazon, brazil.	the present study evaluated the rickettsial infection among dogs living in the rural and urban areas of monte negro, state of rondônia, western brazilian amazon. canine sera were tested by the indirect immunofluorescence assay (ifa) using six rickettsial antigens: rickettsia bellii, rickettsia amblyommii, rickettsia rhipicephali, rickettsia rickettsii, rickettsia parkeri, and rickettsia felis. while the first three rickettsia species are known to occur in the study site, the latter three species ...	2007	17627445
prevalence of antibodies against spotted fever group rickettsiae in a rural area of colombia.	we recently rediscovered rocky mountain spotted fever in villeta, colombia, near the same locality (tobia) where it was first recognized in 1937. to have a better idea of the magnitude of this problem, sera from 392 randomly recruited healthy adults from villeta were analyzed by indirect immunofluorescent antibody assay to detect igg against rickettsia rickettsii as antigen. the seropositivity rate for spotted fever group rickettsiae was 40.3%. we did not find any association between the presenc ...	2007	17690417
tick-borne zoonotic bacteria in wild and domestic small mammals in northern spain.	the prevalence and diversity of tick-borne zoonotic bacteria (borrelia spp., anaplasma phagocytophilum, coxiella burnetii, and spotted fever group rickettsiae) infecting 253 small mammals captured in the basque country (spain) were assessed using pcr and reverse line blot hybridization. trapping sites were selected around sheep farms (study 1, 2000 to 2002) and recreational parks (study 2, 2003 to 2005). the majority of the studied mammals (162) were wood mice (apodemus sylvaticus), but six othe ...	2007	17693556
rocky mountain spotted fever, colombia.	we investigated 2 fatal cases of rocky mountain spotted fever that occurred in 2003 and 2004 near the same locality in colombia where the disease was first reported in the 1930s. a retrospective serosurvey of febrile patients showed that > 21% of the serum samples had antibodies aaainst spotted fever group rickettsiae.	2007	18214179
rocky mountain spotted fever, panama.	we describe a fatal pediatric case of rocky mountain spotted fever in panama, the first, to our knowledge, since the 1950s. diagnosis was established by immunohistochemistry, pcr, and isolation of rickettsia rickettsii from postmortem tissues. molecular typing demonstrated strong relatedness of the isolate to strains of r. rickettsii from central and south america.	2007	18217566
an autonomous polymerization motor powered by dna hybridization.	we present a synthetic molecular motor capable of autonomous nanoscale transport in solution. inspired by bacterial pathogens such as rickettsia rickettsii, which locomote by inducing the polymerization of the protein actin at their surfaces to form 'comet tails', the motor operates by polymerizing a double-helical dna tail2. dna strands are propelled processively at the living end of the growing polymers, demonstrating autonomous locomotion powered by the free energy of dna hybridization.	2007	18654346
[sudden death syndrome in infants in their first year of life; biological maturity and borderline conditions].		2007	2075054
aging and rationing.		2007	1932999
rickettsia rickettsii infection causes apoptotic death of cultured cerebellar granule neurons.		2007	17172530
[the respiratory tract and air pollution].		2008	3053144
long-term results of prosthetic therapy in adult cleft lip alveolus and palate patients.	in the framework of the complex rehabilitation of cleft lip and palate patients the final phase of the dental therapy is attained with the definitive prosthetic treatment. this study comprises 148 prosthetically treated patients in the period 1973 to 1986. the results show that there are good preconditions for an undisturbed professional and social development of the cleft lip and palate patients through intensive dental care.	2008	2691535
the effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependent diabetes mellitus.	insulin-dependent diabetes mellitus (iddm) is associated with an increased risk of coronary artery disease (cad). there is some evidence that polyunsaturated fatty acids of the marine n-3 type (n-3 pufa's) may offer protection against cad. we have studied the effect of short-term dietary supplementation with n-3 pufas on lipids, haemostasis, neutrophil and monocyte chemotaxis in 10 patients with iddm. the patients were given 4 g daily of n-3 pufas (fish oil) for 6 weeks and were investigated bef ...	2008	2706043
infection prevention by selective decontamination in intensive care.		2008	2600283
[flexible arrangement of working time in the field of nursing--a contribution to optimal care].		2008	2329782
use of the megasoft bandage lens for treatment of complications after trabeculectomy.	shallow anterior chambers and leaking filtration blebs are possible complications after trabeculectomy that can be treated with therapeutic contact lenses. in most cases, however, treatment fails because these lenses are not large enough to cover the filtering bleb. we evaluated the use of a newly developed large diameter (20.5 mm) therapeutic soft contact lens. five patients with shallow anterior chambers and ten patients with leaking filtering blebs after trabeculectomy were fitted with this n ...	2008	2396651
evidence of multiple zoonotic agents in a wild rodent community in the eastern sierra nevada.	this study aimed to describe the occurrence of yersinia pestis, rickettsia rickettsii, anaplasma phagocytophilum, and ectoparasites in a wild rodent community in the eastern sierra nevada. from may to september 2006, rodents were live-trapped, examined for ectoparasites, and blood was collected. all rodents were serologically tested for antibodies to y. pestis, r. rickettsii, and a. phagocytophilum; in addition, blood samples and ectoparasites were tested by pcr to detect the presence of these z ...	2008	18689664
molecular detection of spotted fever group rickettsia in dermacentor silvarum from a forest area of northeastern china.	in total, 676 dermacentor silvarum olenev (acari: ixodidae) from a forest area of jilin province in northeastern china were examined by polymerase chain reaction for the presence of spotted fever group (sfg) rickettsia. the overall positive rate was 10.7%, with a 95% confidence interval from 8.3 to 13.0%. the sfg rickettsia infection was more prevalent in adults than in nymphs, and in fed ticks obtained from domestic animals than in those collected on vegetation. sequence analysis of the partial ...	2008	18714877
detection of a spotted fever group rickettsia in the tick ixodes tasmani collected from koalas in port macquarie, australia.	four species of rickettsia are recognized as endemic to australia. this study reports the detection of a new spotted fever group rickettsia in the common marsupial tick ixodes tasmani neumann collected from koalas (phascolarctos cinereus) in port macquarie, nsw, australia. based on the results of polymerase chain reaction (pcr) amplification of extracted tick dna with primers targeting the citrate synthase gene (glta) and the outer membrane proteins a and b (ompa. ompb), rickettsiae were detecte ...	2008	18714878
activation of p38 mitogen-activated protein kinase module facilitates in vitro host cell invasion by rickettsia rickettsii.		2008	18719192
what's new in rocky mountain spotted fever?	rocky mountain spotted fever (rmsf) remains an important illness despite an effective therapy because it is difficult to diagnose and is capable of producing a fatal outcome. the pathogenesis of rmsf remains, in large part, an enigma. however, recent research has helped shed light on this mystery. importantly, the diagnosis of rmsf must be considered in all febrile patients who have known or possible exposure to ticks, especially if they live in or have traveled to endemic regions during warmer ...	2008	18755382
evaluation of conventional and real-time pcr assays for detection and differentiation of spotted fever group rickettsia in dog blood.	spotted fever group rickettsia is important cause of emerging and re-emerging infectious disease in people and dogs. importantly, dogs can serve as sentinels for disease in people. sensitive and specific diagnostic tests that differentiate among species of infecting rickettsia are needed. the objective of this study was to develop a sensitive and specific pcr that differentiates sfg rickettsia infecting dog blood. conventional and real-time pcr assays were developed using primers that targeted a ...	2008	18226476
expressed sequence tags (ests) from the salivary glands of the tick amblyomma cajennense (acari: ixodidae).	the neotropical tick amblyomma cajennense is a significant pest to domestic animals, the most frequently human-biting tick in south america and the main vector of brazilian spotted fever (caused by rickettsia rickettsii), a deadly human disease. the purpose of this study is to characterize the adult a. cajennense salivary gland transcriptome by expressed sequence tags (ests). we report the analysis of 1754 clones obtained from a cdna library, which reveal mainly transcripts related to proteins i ...	2008	18243270
experimental infection of opossums didelphis aurita by rickettsia rickettsii and evaluation of the transmission of the infection to ticks amblyomma cajennense.	the present study evaluated the infection of opossums (didelphis aurita) by rickettsia rickettsii and their role as amplifier hosts for horizontal transmission of r. rickettsii to amblyomma cajennense ticks. three groups of opossums were evaluated: on day 0, group 1 (g1) was inoculated intraperitoneally with r. rickettsii; group 2 (g2) was infested by r. rickettsii-infected ticks; and group 3 (g3) was the uninfected control group. opossum rectal temperature was measured daily. blood samples were ...	2008	18945194
retrospective clinical and molecular analysis of conditioned laboratory dogs (canis familiaris) with serologic reactions to ehrlichia canis, borrelia burgdorferi, and rickettsia rickettsii.	dogs are susceptible to different tickborne infections, including members of the anaplasmataceae (ehrlichia canis, e. ewingii, e. chaffeensis, anaplasma phagocytophilum, a. platys), borrelia burgdorferi, and rickettsia rickettsii. these diseases can manifest with clinical signs including fever, anorexia, malaise, lameness, rash, and bleeding episodes; however, these signs are nonpathognomonic, and infections can occur in the absence of clinical signs. hematologic abnormalities can include leukop ...	2008	18947166
rickettsial spotted fever in capoeirão village, itabira, minas gerais, brazil.	the present study investigated the infection by spotted fever rickettsia in an endemic area for brazilian spotted fever (bsf; caused by rickettsia rickettsii) in minas gerais state, brazil. human, canine and equine sera samples, and amblyomma cajennense adult ticks collected in a rural area of itabira city, minas gerais state were tested for rickettsial infection. through immunofluorescence assay (ifa) we demonstrated the presence of antibodies anti-r. rickettsii in 8.2%, 81.3% and 100% of the h ...	2008	18949349
warmer weather linked to tick attack and emergence of severe rickettsioses.	the impact of climate on the vector behaviour of the worldwide dog tick rhipicephalus sanguineus is a cause of concern. this tick is a vector for life-threatening organisms including rickettsia rickettsii, the agent of rocky mountain spotted fever, r. conorii, the agent of mediterranean spotted fever, and the ubiquitous emerging pathogen r. massiliae. a focus of spotted fever was investigated in france in may 2007. blood and tissue samples from two patients were tested. an entomological survey w ...	2008	19015724
laboratory maintenance of rickettsia rickettsii.	this unit includes protocols for the laboratory maintenance of the obligate intracellular bacterium rickettsia rickettsii, including propagation in mammalian cell cultures, as well as isolation, counting, and storage procedures. regulations for working with r. rickettsii in biosafety level 3 containment are also discussed.	2008	19016440
molecular characterization of rickettsia rickettsii isolated from human clinical samples and from the rabbit tick haemaphysalis leporispalustris collected at different geographic zones in costa rica.	five strains of spotted fever group (sfg) rickettsiae previously isolated from human clinical cases and from the tick haemaphysalis leporispalustris were used for molecular characterization in this study to establish their genetic relationship compared with the prototype rickettsia rickettsii strain sheila smith. samples were tested by polymerase chain reaction (pcr) targeting the rickettsial genes gtla, ompa, and ompb. pcr products of the latter two genes were dna sequenced and compared with av ...	2008	19052300
experimental infection of dogs with a brazilian strain of rickettsia rickettsii: clinical and laboratory findings.	the bacterium rickettsia rickettsii is the etiological agent of an acute, severe disease called rocky mountain spotted fever in the united states or brazilian spotted fever (bsf) in brazil. in addition to these two countries, the disease has also been reported to affect humans in mexico, costa rica, panama, colombia and argentina. like humans, dogs are also susceptible to r. rickettsii infection. however, despite the wide distribution of r. rickettsii in the western hemisphere, reports of r. ric ...	2008	19057821
comparative susceptibility of larval stages of amblyomma aureolatum, amblyomma cajennense, and rhipicephalus sanguineus to infection by rickettsia rickettsii.	the current study compared the susceptibility of larval stages of amblyomma cajennense (f.), amblyomma aureolatum (pallas), and rhipicephalus sanguineus (latreille) to infection by a brazilian strain of rickettsia rickettsii. guinea pigs experimentally infected by r. rickettsii were simultaneously infested by larvae of the three tick species. recovered engorged larvae were allowed to molt to nymphs and held in an incubator at 23 degrees c and 85-90% rh. subsequent flat nymphs were tested for ric ...	2008	19058642
host defenses to rickettsia rickettsii infection contribute to increased microvascular permeability in human cerebral endothelial cells.	rickettsiae are arthropod-borne intracellular bacterial pathogens that primarily infect the microvascular endothelium leading to systemic spread of the organisms and the major pathophysiological effect, increased microvascular permeability, and edema in vital organs such as the lung and brain. much work has been done on mechanisms of immunity to rickettsiae, as well as the responses of endothelial cells to rickettsial invasion. however, to date, no one has described the mechanisms of increased m ...	2008	17957455
rocky mountain spotted fever in argentina.	we describe the first molecular confirmation of rickettsia rickettsii, the cause of rocky mountain spotted fever (rmsf), from a tick vector, amblyomma cajennense, and from a cluster of fatal spotted fever cases in argentina. questing a. cajennense ticks were collected at or near sites of presumed or confirmed cases of spotted fever rickettsiosis in jujuy province and evaluated by polymerase chain reaction assays for spotted fever group rickettsiae. dna of r. rickettsii was amplified from a pool ...	2008	18385370
molecular identification of rickettsia felis in ticks and fleas from an endemic area for brazilian spotted fever.	rickettsioses are arthropod-borne diseases caused by parasites from the order rickettsiales. the most prevalent rickettsial disease in brazil is brazilian spotted fever (bsf). this work intends the molecular detection of those agents in ectoparasites from an endemic area of bsf in the state of espírito santo. a total of 502 ectoparasites, among them amblyomma cajennense, amblyomma dubitatum (a. cooperi), riphicephalus sanguineus, anocentor nitens and ctenocephalides felis, was collected from dom ...	2008	18425272
tick-borne diseases in north carolina: is "rickettsia amblyommii" a possible cause of rickettsiosis reported as rocky mountain spotted fever?	cases of rocky mountain spotted fever (rmsf) in north carolina have escalated markedly since 2000. in 2005, we identified a county in the piedmont region with high case numbers of rmsf. we collected ticks and examined them for bacterial pathogens using molecular methods to determine if a novel tick vector or spotted fever group rickettsiae (sfgr) might be emerging. amblyomma americanum, the lone star tick, comprised 99.6% of 6,502 specimens collected in suburban landscapes. in contrast, dermacen ...	2008	18447622
adrenal gland hemorrhage in patients with fatal bacterial infections.	a wide spectrum of adrenal gland pathology is seen during bacterial infections. hemorrhage is particularly associated with meningococcemia, while abscesses have been described with several neonatal infections. we studied adrenal gland histopathology of 65 patients with bacterial infections documented in a variety of tissues by using immunohistochemistry. the infections diagnosed included neisseria meningitidies, group a streptococcus, rickettsia rickettsii, streptococcus pneumoniae, staphylococc ...	2008	18500257
detection and identification of spotted fever group rickettsiae in dermacentor species from southern california.	dermacentor occidentalis marx and dermacentor variabilis (say) commonly bite humans in california. these dermacentor species may play a role in transmitting spotted fever group (sfg) rickettsiae to humans in many parts of the state where dermacentor andersoni stiles, a known vector for the etiologic agent of rocky mountain spotted fever, rickettsia rickettsii, is absent. however, the specific rickettsial agents present in these ticks and their current prevalence are poorly understood. in total, ...	2008	18533446
a case of murine typhus associated with large vessel infarct of the spleen.	we present a case of rickettsia typhi infection (the causative agent of endemic typhus) associated with an isolated splenic infarction. large vessel infarction is a rare complication of murine typhus, unlike infections caused by rickettsia rickettsii and rickettsia conorii (the spotted fever group rickettsias) which are known to cause hemostatic changes that lead to coagulopathies and thrombotic events. this case adds to the scarce data in the literature on the association between large vessels ...	2008	18552585
curvature and torsion in growing actin networks.	intracellular pathogens such as listeria monocytogenes and rickettsia rickettsii move within a host cell by polymerizing a comet-tail of actin fibers that ultimately pushes the cell forward. this dense network of cross-linked actin polymers typically exhibits a striking curvature that causes bacteria to move in gently looping paths. theoretically, tail curvature has been linked to details of motility by considering force and torque balances from a finite number of polymerizing filaments. here we ...	2008	18560043
canine infection by rickettsiae and ehrlichiae in southern brazil.	this study evaluated the infection caused by rickettsia and ehrlichia agents among dogs in southern brazil. a total of 389 dogs were tested by the indirect immunofluorescence assay (ifa) for rickettsia rickettsii, rickettsia parkeri, rickettsia amblyommii, rickettsia rhipicephali, rickettsia bellii, and ehrlichia canis. overall, 42.4% (165/389) of the dogs were seroreactive to at least one rickettsia species, but only 11 canine sera reacted with another rickettsia species without reacting with r ...	2008	18606772
characterization of rickettsia rickettsii in a case of fatal brazilian spotted fever in the city of rio de janeiro, brazil.	a lethal case of brazilian spotted fever (bsf) is presented. clinical features were initially of gastrointestinal involvement and evolved with progression to septic shock, meningoencephalitis and death on the 6th day of illness. indirect immunofluorescence assay (ifa) for spotted fever group rickettsia (sfgr) was non-reactive. diagnosis was confirmed by the polymerase chain reaction (pcr) and the nucleotide sequencing of a fragment of the ompa gene showed 100% homology to rickettsia rickettsii. ...	2008	18641853
genomic comparison of virulent rickettsia rickettsii sheila smith and avirulent rickettsia rickettsii iowa.	rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of rocky mountain spotted fever. to identify genes involved in the virulence of r. rickettsii, the genome of an avirulent strain, r. rickettsii iowa, was sequenced and compared to the genome of the virulent strain r. rickettsii sheila smith. r. rickettsii iowa is avirulent in a guinea pig model of infection and displays altered plaque morphology with decreased lysis of infected host cells. comparison of the t ...	2008	18025092
prevalence of seropositivity to spotted fever group rickettsiae and anaplasma phagocytophilum in a large, demographically diverse us sample.	most epidemiologic studies of tick-borne rickettsial diseases in the united states are small and have limited demographic scope, making broader risk assessment difficult.	2008	18171216
bites and stings. part 2. bees and vespids.		2008	2519523
[measurement of orthodontic appliance force using prototype sensors].	in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ...	2008	2635572
results of pharmacokinetic studies with de-noltab.		2008	2518856
patton's utilization-focused evaluation as the basis of the quality assurance process.		2008	3403687
[present state of conservative breast therapy in canada].		2008	2746948
[ki-1 large cell lymphoma with secondary xanthomatous infiltration of the lesions by chemotherapy].		2008	2575882
prognostic indicators in head and neck cancer patients receiving combined therapy.	in 1983 we initiated a prospective nonrandomized study of the value of preoperative chemotherapy in previously untreated patients with stages iii and iv squamous cell carcinoma of the head and neck. in 1983 and 1984, 50 patients were entered in the study. prior to therapy all patients were evaluated by a representative from the medical oncology, radiation therapy, and head and neck surgery divisions, university of utah school of medicine, salt lake city. in addition to the standard preoperative ...	2008	2573381
hip surgery in adults.		2008	2223439
copper(i)-bleomycin: structurally unique complex that mediates oxidative dna strand scission.	copper(i)-bleomycin [cu(i) x blm] was characterized in detail by 13c and 1h nmr. unequivocal chemical shift assignments for cu(i) x blm and cu(i) x blm x co were made by two-dimensional 1h-13c correlated spectroscopy and by utilizing the observation that cu(i) x blm was in rapid equilibrium with cu(i) and metal-free bleomycin, such that individual resonances in the spectra of blm and cu(i) x blm could be correlated. the binding of cu(i) by bleomycin involves the beta-aminoalaninamide and pyrimid ...	2008	2581602
[space-occupying lesions in the gallbladder in cholecystolithiasis. freiburg gastroenterology consultation].		2008	2725428
[psychological stress at work and health status of medical personnel].		2008	2267842
a reappraisal of the terverticillate penicillia using biochemical, physiological and morphological features. i. numerical taxonomy.	three-hundred-and-forty-eight strains representing the major species of terverticillate penicillia, and including representatives of other closely and distantly related species, were included in a numerical taxonomic study. one-hundred characters were derived from morphological features, physiological and biochemical activities and sem micrographs. strains were compared by both gower's coefficient and pattern difference, and clustered using the average linkage algorithm. thirty-seven species or ...	2008	2614375
surgical treatment of the iliotibial band friction syndrome.	a selected group of 23 patients underwent surgery for iliotibial band friction syndrome. among the patients presenting with this exertional pain syndrome were runners, football players, and cyclists. diagnosis was clinical since radiographs were negative and an ultrasound examination was positive in only one case, showing an aberrant picture around the lateral femoral epicondyle. although conservative treatment is effective in most cases, an alternative is needed for patients with complaints tha ...	2008	2610280