Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| carcinomas of bartholin's gland. histogenesis and the etiological role of human papillomavirus. | in this study, we examine 10 primary carcinomas of bartholin's gland, including seven squamous carcinomas, two adenoid cystic carcinomas, and one adenocarcinoma, as well as four non-neoplastic bartholin's gland. six of seven squamous cell carcinomas contained human papillomavirus (hpv) type 16 dna detectable by the polymerase chain reaction; one of these demonstrated hpv type 16 by in situ hybridization. the two adenoid cystic carcinomas, the adenocarcinoma, and the non-neoplastic bartholin's gl ... | 1993 | 8384409 |
| detection and typing of human papillomavirus dna in the uterine cervix of japanese women by nonradioactive dot blot and southern blot hybridization. | hpv infection was examined with cytobrush in exfoliated cervical cells sampled from 347 women. hpv dna analysis was conducted in two steps. the presence of hpv dna was demonstrated by dot blotting and typing of hpv dna was made by southern blotting using biotinylated probes. of 167 cases with cervical intra-epithelial neoplasia (cin) and cervical carcinoma, hpv dna was detected and typed in 25 cases (15.0%). hpv 16, 18, and 33 were found mainly, and no hpv 6 or 11 was detected. the frequency of ... | 1993 | 8384546 |
| detection of human papillomavirus 16 and 18 dna in epithelial lesions of the lower genital tract by in situ hybridization and polymerase chain reaction: cervical scrapes are not substitutes for biopsies. | human papillomavirus (hpv) types 16 and 18 in 66 women with histologically documented lesions of the genital tract and 64 control cohorts were investigated. the efficacies of in situ hybridization and polymerase chain reaction (pcr) in detecting hpv 16 and 18 dna were analyzed. in order to assess the usefulness of replacing biopsies with cervical scrapes, the two samples were compared by pcr. the prevalence rates of hpv infection by pcr were 59.1 and 10.9% in patients and controls, respectively. ... | 1993 | 8385153 |
| rapid preparation of tissue dna from paraffin-embedded blocks and analysis by polymerase chain reaction. | we have developed a new, easy, and more rapid method for dna preparation, which avoids contamination. with this method, manual surgical blade scrapings from precisely targeted areas of paraffin block surfaces, without microtome cutting, were used to obtain tissues from 10 different neoplasms. our results indicate the feasibility of dna extraction from the scraped paraffin tissue for molecular genetic analysis. we applied this technique successfully to screen for the presence of human papillomavi ... | 1993 | 8385683 |
| common warts from immunocompetent patients show the same distribution of human papillomavirus types as common warts from immunocompromised patients. | we studied the papillomaviruses (hpv) found in 131 common warts from 111 immunocompetent patients by amplification of viral dna sequences with the general-primer-mediated polymerase chain reaction (pcr). the virus types were determined by restriction-enzyme cleavage and reverse-blot analysis. results were confirmed by using the southern blot technique. forty patients harboured hpv 2a, 25 individuals showed hpv 2c and 13 yielded hpv 57. common warts from 16 patients were induced by a variant of h ... | 1993 | 8385983 |
| varied clinical morphology of hpv-1-induced warts, depending on anatomical factors. | the clinical and histological features of 49 lesions induced by human papillomavirus type 1 (hpv-1) were studied. the majority of cases showed the typical clinical features and location of such lesions. they were usually located on the ventral or lateral surfaces of the hands or feet, and were dome-shaped lesions with a central depression. however, hpv-1-induced lesions located on other body areas displayed different clinical features, such as those of common warts, a digitate wart, and a cutane ... | 1993 | 8385984 |
| expression of the different viral mrnas of human papilloma virus 6 in a squamous-cell carcinoma of the bladder and the cervix. | the prevalence of hpv6 and hpv11 in benign condylomata or mild dysplasias has led to the view of hpv6/11 as rather harmless viruses in relation to carcinogenesis. however, the detection of hpv6/11 dna in a number of individual cases of squamous-cell carcinomas of the anogenital/urinary tract could also point to a possible contribution of these viruses in the development of certain malignancies. recently we have shown that the transcription of the e6 and e7 genes of hpv6 in benign anogenital cond ... | 1993 | 8386138 |
| the discrimination of high-risk hpv types by in situ hybridization and the polymerase chain reaction. | the parameter tmt has been defined by non-isotopic in situ hybridization and describes the tissue melting temperature (tmt) of human papillomavirus (hpv) dna sequences. in this study, multiple in situ hybridization signals for hpv types 16, 31 and 33 in individual archival biopsies hybridized with genomic probes are shown by polymerase chain reactions to be due to cross-hybridization of probe sequences to a single tissue target. tmt is independent of viral type but depends on the homology betwee ... | 1993 | 8386149 |
| [correlation between chronic hyperplastic laryngitis and infection with human papillomaviruses]. | cancer of the larynx is one of the most prevalent tumors of the head and neck, with its prognosis dependent on early diagnosis. a number of authors have now reported a connection between head and neck cancers and infection with human papilloma virus (hpv). a large number of these tumors has been found to be hpv 16/18 positive, with results ranging from 10% to 75% positive. it is currently known that viral infection alone cannot realize an oncogenic potential and there have to be exogenous and/or ... | 1993 | 8386152 |
| [human papilloma virus infections in adult women in panama]. | this study shows that 10% of panamanian women are infected with vph. this incidence of premalign and malign infection is one of the highest in the world. it is necessary that panamanian women be educated to participate in the program of the early detection of the disease to control the incidence of cancer in the uterine cervix. | 1993 | 8386390 |
| analysis of prevalence of human papillomavirus in laryngeal carcinomas. study of 40 cases using polymerase chain reaction and consensus primers. | in this study we determined the frequency of association of human papillomavirus (hpv) and laryngeal carcinomas and investigated the possibility that hpv may be associated with larger or more aggressive tumors. laryngeal squamous cell carcinomas from 40 patients who did not have preexisting papillomas by clinical history were retrieved from formalin-fixed, paraffin-embedded blocks and analyzed for hpv. twenty-two cases were tumors of the true vocal folds, and 18 were supraglottic. clinical follo ... | 1993 | 8386490 |
| human papillomavirus in primary epithelial tumors of the lacrimal sac. | the lacrimal sac epithelium can give rise to benign and malignant neoplasms. human papillomavirus (hpv) infection is known to be causal in the development of epithelial neoplasias elsewhere in the body. the authors have examined primary lacrimal sac tumors for the presence of hpv. | 1993 | 8386822 |
| [in vivo identification of yb-1 protein, interacting with the enhancer of human papillomavirus (hpv) type 18, using antibodies to a synthetic peptide]. | enhancer sequences of human papilloma virus (hpv) type 18 were used for screening of hela cells cdna library in lambda gt11 using the protein binding method. clones with yb i gene homology sequences were isolated. this gene is coding the protein which binds the regulatory region of y gene of main histocompatibility complex (hla 11). the yb i transcripts were revealed in all tested samples of cervical carcinomas. to analyze the protein the rabbit antibodies were produced to synthetic peptide, whi ... | 1993 | 8387154 |
| human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. | we examined human papillomavirus (hpv) infection in biopsy specimens and cellular scrapes that were taken from respiratory papillomas and six nondiseased sites from the respiratory tract of seven patients. human papillomavirus was detected by polymerase chain reaction amplification, followed by dna hybridization with probes for specific hpv types. all papillomas (100.0%, n = 5) were positive only for hpv type 6 or 11. in the nondiseased site specimens, 61.3% (19/31) of the specimens were positiv ... | 1993 | 8387317 |
| genital types of papillomavirus in children of women with hiv-1 infection in kinshasa, zaire. | increasing evidence indicates that infection with genital types of human papillomavirus (hpv) can occur prior to the onset of sexual activity, possibly by perinatal transmission. evidence is also accumulating that women infected with the human immunodeficiency virus (hiv) more frequently express hpv. we conducted this study to measure hpv prevalence in hiv-seropositive and -seronegative women in kinshasa, zaire and in their children. we collected cervico-vaginal lavage specimens from 80 mothers ... | 1993 | 8387461 |
| prognostic significance of human papillomavirus genomes (type-16, -18) and aberrant expression of p53 protein in human esophageal cancer. | the presence and distribution of human papillomavirus (hpv) dna or of increased expression of the p53 protein were determined in 71 patients with esophageal squamous-cell carcinoma (scc) by in situ hybridization with biotinylated dna probes for hpv-16, -18, -31 and -33, and immunohistochemical techniques using antibody to p53 protein. of 71 patients from kochi prefecture, 24 (group i) were positive for hpv dna, including 10 for hpv type-16 and 14 for hpv type-18; in contrast, none were positive ... | 1993 | 8387463 |
| analysis of human papillomavirus dna in oral squamous cell carcinomas. | evidence from several laboratories suggests that hpv plays a role in the etiology of squamous cell carcinomas of the oral cavity. a multifactorial risk factor profile for the development of oral cancer may include hpv in addition to well-established risk factors such as tobacco and alcohol use. the prevalence of oral carcinomas reported to be associated with hpv has varied widely due to differences in the sensitivity of the assay used for hpv detection. the aims of this study were: (1) to ascert ... | 1993 | 8387592 |
| evolution of the antibody response to human papillomavirus type 11 (hpv-11) in patients with condyloma acuminatum according to treatment response. | to evaluate the variation over time of seroreactivity to human papillomavirus type 11 (hpv-11) according to disease outcome, we selected a sample of 42 condyloma acuminatum patients from a group of subjects enrolled in a placebo-controlled trial of three alpha-interferon preparations administered parenterally for the treatment of condyloma acuminatum. this sample included 14 subjects who were cured by the end of follow-up (cured group) and 28 subjects who were not (failed group). for each indivi ... | 1993 | 8388030 |
| repression of endogenous p53 transactivation function in hela cervical carcinoma cells by human papillomavirus type 16 e6, human mdm-2, and mutant p53. | somatic mutations in the p53 tumor suppressor gene represent the single most common genetic alteration observed in human cancers. interestingly, the great majority of malignant tumors of the cervix uteri contain wild-type p53 alleles together with the dna of specific types of human papillomaviruses (hpvs), while the small portion of hpv-negative cervical carcinomas often carry alterations in the p53 tumor suppressor gene. transcriptional activation of yet-undefined cellular regulatory genes has ... | 1993 | 8388491 |
| inhibition of growth, transformation, and expression of human papillomavirus type 16 e7 in human keratinocytes by alpha interferons. | we used a model system of normal human keratinocytes (hkc) and hkc immortalized with human papillomavirus type 16 dna (hkc/hpv16) to investigate the effects of alpha interferons (ifn-alpha) on the growth of hpv16-immortalized human epithelial cells, on hpv16-mediated immortalization of normal hkc, and on hpv16 gene expression. normal hkc and hkc/hpv16 were treated with several recombinant human ifn-alpha subtypes (ifn-alpha b, ifn-alpha d, and ifn-alpha b/d). these ifn-alpha subtypes inhibited p ... | 1993 | 8388505 |
| smoking and human papillomavirus infection. cervical epithelium vulnerable in smokers. | 1993 | 8388757 | |
| frequency of sexually transmitted diseases among university students. | to estimate the incidence rate of sexually transmitted diseases (stds) among university students and evaluate the associated sociodemographic factors. | 1993 | 8388772 |
| behavior of cervical intraepithelial neoplasia (cin) associated with various human papillomavirus (hpv) types. | 201 cervical punch biopsies which showed cin lesions and were obtained between 1967 to 1977 from falu hospital patients, with long-term follow-up data were examined histologically and by dna typing for human papillomavirus (hpv). we used in situ hybridization for hpv types 6, 11, 16, 18, 31 and 33 and related our findings to the behaviour of the lesion (103 regressed spontaneously and 98 progressed, some of them to invasive cervical carcinoma). there was evidence of hpv infection in 75.6% (152/2 ... | 1993 | 8389112 |
| is human papillomavirus-related disease an independent risk factor for human immunodeficiency virus infection? | we sought to determine the prevalence of human immunodeficiency virus (hiv) infection in a population of women with human papillomavirus (hpv)-related diseases attending a colposcopy clinic who had no other cdc-defined risk factors for hiv. study patients included all new patients attending our colposcopy clinic who were found to have histologic evidence of condyloma or cervical intraepithelial neoplasia. those patients not already known to be hiv-positive were offered testing for hiv. demograph ... | 1993 | 8389313 |
| possible non-sexual transmission of genital human papillomavirus infections in young women. | human papillomaviruses were detected by an in vitro enzymatic dna amplification method in cells obtained from vulvar swabs of 9 of 61 (14.8%) young women without prior experience of sexual intercourse and in 7 of 57 (12.3%) young women with prior experience. the prevalence of human papillomavirus dna in these two groups of women was not significantly different (x2 = 0.16, p > 0.5; 95% confidence interval -0.165 to 0.215). these results suggest that genital human papillomavirus is not sexually tr ... | 1993 | 8389707 |
| gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines. | using immunocytochemical and western blotting techniques we have demonstrated the presence of abnormally high levels of p53 protein in 8/24 (33%) of human squamous cell carcinomas (scc) and 9/18 (50%) of scc cell lines. there was a correlation between the immunocytochemical results obtained with eight scc samples and their corresponding cell lines. direct sequencing of pcr-amplified, reverse transcribed, p53 mrna confirmed the expression of point mutations in six of the positive cell lines and d ... | 1993 | 8390283 |
| hairy leukoplakia after bone marrow transplantation. | hairy leukoplakia in 10 patients after bone marrow transplantation was identified clinically and assessed histologically. in situ hybridization for epstein-barr virus and human papilloma virus confirmed epstein-barr virus in hairy leukoplakia in two cases, and human papillomavirus in three cases. all cases with clinical follow-up resolved without treatment. these findings suggest that severe immunosuppression after a bone marrow transplantation may result in the development of hairy leukoplakia, ... | 1993 | 8390632 |
| papillomavirus infection and its pathologic correlate in sexually active adolescents. | we investigated the prevalence of human papillomavirus (hpv) and its pathologic correlation in an adolescent clinic population (13-20 years, mean 16 years) over a 2-year period. 413 cervical specimens were obtained and analyzed cytologically and by a southern blot (sb) method for hpv dna. 277 specimens from 210 patients could be fully analyzed. 23 patients (10.9%) were positive for hpv dna by sb. cytologic findings in these 23 patients demonstrated changes compatible with low-grade squamous intr ... | 1993 | 8390646 |
| hpv, hiv infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers. | the relation between human immunodeficiency virus (hiv), human papilloma virus (hpv) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (cin) has been analyzed in a cross-sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the colposcopic unit of the ospedale luigi sacco of milan and women consecutively admitted to the community for past drug abusers, s. patrignano, rimini. a total of 434 su ... | 1993 | 8390961 |
| [expression of human papillomavirus (hpv) gene in hpv-positive laryngeal tumors and activity of the hpv long control region in cultured normal laryngeal epithelial cells]. | expression of the human papillomavirus (hpv) gene was examined in hpv-positive laryngeal tumors. moreover, the activity of the hpv long control region (lcr) was tested in cultured laryngeal epithelial cells. hpv-11 early genes were heterogeneously expressed in adult laryngeal papillomas. we found one laryngeal carcinoma case in whom the hpv-16 transforming genes, e6 and e7, were expressed. both hpv-11 and -16 lcrs were active in cultured laryngeal epithelial cells from vocal cords. these results ... | 1993 | 8391073 |
| [human papilloma virus infection in the case of larynx carcinoma]. | the case of 59 year old man treated for larynx carcinoma was presented. the potentially oncogenic human papillomavirus type 16/18 was detected in the tissue surrounding the tumor. | 1993 | 8391130 |
| construction of site-specific mutants of e5a protein of hpv-11 using the polymerase chain reaction and a single mutant primer. | the method of perrin and gilliland (1990) was modified to create site-specific mutants. the polymerase chain reaction and a single mutant primer are needed to carry out site-specific mutagenesis. using this method, removal of the excess primers and nucleotides from the initial amplification is not necessary. this method provides a simpler way to generate site-specific mutants. | 1993 | 8391542 |
| human papillomavirus dna in the urogenital tracts of men with genital dermatoses: evidence for multifocal infection. | in an attempt to assess the multifocal nature of anogenital hpv infection in men, skin biopsies, urethral swabs and urine specimens were obtained from 100 men with genital dermatoses. the specimens were examined for the presence of human papillomavirus (hpv) types 6, 11, 16, 18, 31 and 33 using the polymerase chain reaction and southern blotting techniques. hpv dna was detected in one or more specimens from 39 patients, that is 29 of 100 biopsy specimens, 21 (25%) of 85 urethral swab specimens a ... | 1993 | 8391854 |
| demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. | this report describes one case of verrucous carcinoma of the foot containing human papillomavirus type 2 dna which was detected by the polymerase chain reaction dna amplification method. our findings suggest that human papillomavirus type 2, which was classically associated with palmoplantar warts, may also play a role in the pathogenesis of peripheral verrucous carcinoma. | 1993 | 8391880 |
| immunohistochemical analysis of p53 expression in anal squamous neoplasia. | to determine the pattern of expression of the p53 tumour suppressor gene product in anal squamous neoplasia, and to determine if this could be used as a marker of disease progression. the association between p53 expression and human papillomavirus (hpv) 16 dna status of the anal lesions was also investigated. | 1993 | 8392521 |
| high- and low-power co2 lasers. comparison of results for three clinical indications. | in this prospective study, three groups of patients were enrolled: group 1, patients with high grade squamous intraepithelial lesions (cin 2 and 3) and carcinoma in situ (n = 56); group 2, patients with benign vulvar and perineal human papillomavirus lesions (n = 83); and group 3, patients with disseminated foci of penile shaft condylomatous lesions (n = 65). each of the groups was randomly equally divided into two subgroups. one subgroup was treated with a laser beam with an output of 60 w and ... | 1993 | 8392581 |
| nuclear factor i and epithelial cell-specific transcription of human papillomavirus type 16. | the transcription of human papillomavirus type 16 (hpv-16) is mediated by the viral enhancer. epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors. one of them, nuclear factor i (nfi), binds seven sites within the hpv-16 enhancer. point mutations on enhancer fragments, which retain epithelial cell specificity, verify the functional contribution of nfi. in band shift experiments, the epithelial cell-derived nfi proteins ct ... | 1993 | 8392590 |
| biology and colposcopic features of human papillomavirus-associated cervical disease. | target biopsy and transformation zone ablation on excision is the mainstay of management for cervical lesions that can be adequately visualized. for the physician who does not progress beyond whimsical estimates of lesion prominence (which cannot differentiate minor- from major-grade lesions), the colposcope will never be more than a simple aid to the collection of directed biopsy specimens. unfortunately, in situations in which the clinician's only option is passive response to the histopatholo ... | 1993 | 8392673 |
| colposcopy of vaginal and vulvar human papillomavirus and adjacent sites. | human papillomaviral infections can affect the entire lower female genital tract as multifocal or multicentric disease as well as the surrounding anatomic and adjacent sites. the traditional colposcopic methods are necessary to assist in the diagnosis and help differentiate these infections from other disease mimics. | 1993 | 8392676 |
| pathogenesis of genital hpv infection. | clinical, subclinical, and latent human papillomavirus (hpv) infections are distinguished from hpv-associated neoplasia. besides hpv additional cofactors are necessary to transform hpv infected tissue to intraepithelial or invasive neoplasia. risk factors for the presence of hpv are high number of sexual partners, early cohabitarche, young age at first delivery, suppression and alteration of immune status, young age and hormonal influences. while the fact of a high number of sexual partners excl ... | 1993 | 8392965 |
| high rate of concurrent genital infections with human cytomegalovirus and human papillomaviruses in cervical cancer patients. | a case-control study evaluated a possible association between infection with human papillomavirus (hpv) or cytomegalovirus (cmv) and cervical cancer. seventy-eight patients with cervical cancer (cases) were compared with 55 age-compatible patients with uterine leiomyoma (controls). genital cmv and hpv infections were diagnosed by polymerase chain reaction amplification of viral dna in cervical tissues. smoking, first coitus or pregnancy before age 20, multiple sex partners, history of multiple p ... | 1993 | 8393059 |
| human papilloma virus: implications for medical directors. | 1993 | 8393222 | |
| mutations of p53 and human papillomavirus infection in cervical carcinoma. | oncogenic human papillomavirus (hpv) infection has been implicated in the pathogenesis of cervical carcinoma. the hpv oncoproteins e6 and e7 are though to play a crucial role in this process by their interactions with the p53 protein and the retinoblastoma susceptibility gene product, respectively. the e6 protein binds to and stimulates the degradation of the p53 protein. mutations involving evolutionary conserved regions of the p53 gene also can alter p53 function. point mutations of p53 freque ... | 1993 | 8393371 |
| interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. | human papillomaviruses (hpvs) contribute to the development of almost all cervical cancers, a common and often fatal human disease. the mechanisms by which the hpvs function in malignant progression appear to be related to the activity of the two viral oncoproteins, e6 and e7, which form complexes with several cell proteins normally involved in controlling cell growth. of particular interest has been the association of e6 with p53 and e7 with rb, both products of tumor suppressor genes. expressi ... | 1993 | 8393818 |
| viral gene detection in oral neoplasms using the polymerase chain reaction. | eighty-four squamous cell proliferative lesions of the oral cavity and six examples of normal oral squamous mucosa were investigated for the presence of human papillomavirus (hpv) by the polymerase chain reaction (pcr) using universal primers and type specific probes. human papillomavirus was identified in 1 of 6 histologically normal biopsy specimens, 2 of 4 hyperplasias, 2 of 5 inflammatory lesions, 9 of 36 cases of dysplasia or carcinoma in situ, and 7 of 39 carcinomas. all of the specimens f ... | 1993 | 8394047 |
| multiple human papillomavirus type 16 glucocorticoid response elements functional for transformation, transient expression, and dna-protein interactions. | we have previously shown that human papillomavirus type 16 (hpv-16) can efficiently transform primary baby rat kidney cells in the presence of the steroid hormones progesterone and the glucocorticoid dexamethasone. to study this effect of hormone, different combinations of the previously identified glucocorticoid response element (gre) at nucleotide 7640 of hpv-16 and the other two gres that we have recently identified, at nucleotides 7385 and 7474, were mutated. the previously described gre and ... | 1993 | 8394465 |
| [a new method, based on in situ dna hybridization, for the detection of papillomavirus in condyloma patients and their partners]. | the detection and typing analysis of human papillomavirus (hpv) were carried out by means of biohit in situ hpv dna hybridization screening and typing kits in condyloma tissues of patients with genital condyloma acuminatum, in cytological smears of their asymptomatic female consorts, and in female patients with vulval condyloma acuminatum. "low"-risk hpv 6 and hpv 11 were demonstrated most frequently in the condyloma tissues of the male patients. it is noteworthy that all but one female consorts ... | 1993 | 8394562 |
| flat wart of the urethra caused by human papillomavirus type 16. | a rare case of urethral flat wart caused by human papillomavirus (hpv) type 16 was reported. a 34-year-old male consulted our department with a complaint of urethral bleeding. a pair of symmetrical white flat warts combined with ulcer at the urethral meatus were found. microscopic examination of the specimen demonstrated koilocytosis of the epithelium. in immunohistochemical study it was positive for hpv and hpv type 16 was detected by polymerase chain reaction. | 1993 | 8394608 |
| sequence variation in the noncoding region of human papillomavirus type 16 detected by single-strand conformation polymorphism analysis. | human papillomavirus (hpv) type 16 variants were found by single-strand conformation polymorphism (sscp) analysis of the noncoding region of the viral genome. two sets of primers were used to analyze a 1018 bp region spanning nucleotides 7109-222. twelve sscp patterns were demonstrated among hpv 16 dnas purified from 48 anal specimens from 24 homosexual men. seven patterns were detected among 10 hpv 16 isolates from cervical carcinomas. in two pairs of sex partners, identical variants were recog ... | 1993 | 8394860 |
| langerhans cells and human papillomaviruses in oesophageal and laryngeal carcinomas. | human papillomavirus (hpv) infection is implicated in squamous cell carcinogenesis. oesophageal carcinoma has a high incidence in certain geographical regions and, using different methods of detection, hpvs have been found in these tumours. hpv 6 and 11 are frequently detected in laryngeal papillomas, benign lesions which rarely become malignant. hpvs have been detected in squamous carcinoma of the larynx but more frequently, especially hpv 16, in verrucous carcinomas a distinct variant of squam ... | 1993 | 8395235 |
| [cloning and characterization of the genome of human papilloma virus type 16 in china]. | the cloning and characterization of a whole genome of human papillomavirus type 16(7.9kb) and a 5.4kb subgenomic fragment were studied. they were cloned after insertion in plasmid pat153, using its unique bamh1 site. the full-length genome and subgenomic fragment were designated hpv16z and hpv16f respectively. after analysis by 16 endonucleases, no new restriction site was found in hpv16z in comparison with the standard strain. a new bamh1 site was observed at the 750 bp position in hpv16f. usin ... | 1993 | 8395318 |
| biological and biochemical activity of e7 genes of the cutaneous human papillomavirus type 5 and 8. | in contrast to the observed activity of the e7 genes of the genital high-risk human papillomavirus (hpv)16 and hpv18, e7s of the cutaneous high-risk hpv5 and hpv8 show no in vitro transforming activity in established rodent cells. we recently reported that the hpv8 e7 driven by the sv40 enhancer/promoter oncogenically transforms primary rat embryo fibroblast (ref) cells collaboratively with the ejras oncogene (jpn. j. cancer res., 82, 1340-1343, 1991). to study the functional differences between ... | 1993 | 8395681 |
| analysis of the growth properties and physical state of the human papillomavirus type 16 genome in cell lines derived from primary cervical tumors. | we have established three cell lines from keratinizing and nonkeratinizing cervical carcinomas with distinct growth properties in vitro and in vivo. each cell line contained human papillomavirus type 16 dna sequences, but the lines differed in the physical state of the viral genome present in the cells. a high copy number of episomal human papillomavirus type 16 dna sequences was detected in the tc-140 line derived from a keratinizing cervical cancer. this cell line had an aneuploid karyotype, d ... | 1993 | 8395773 |
| human papillomavirus-induced verrucous carcinoma of the mouth. case report of an aggressive tumor. | 1993 | 8396162 | |
| hpv dna in oropharyngeal squamous cell cancers: comparison of results from four dna detection methods. | oropharyngeal squamous cell cancers (sccs) were examined for human papillomavirus (hpv) related dna sequences. the techniques employed were southern blotting under stringent and non stringent conditions, dot blotting, primer directed gene amplification using the polymerase chain reaction (pcr), and in-situ hybridization. hpv 16 dna was found in 4 of 30 tumor samples using pcr. hpv 16 dna was found in 2 further tumors using in-situ hybridization. no hpv dna could be found by southern blot or dot ... | 1993 | 8396231 |
| in vitro hpv-11 infection of human foreskin. | study of the infectious process of human papillomavirus type 11 (hpv-11) has been facilitated by the discovery that hpv-11-infected neonatal human foreskin epithelium can proliferate as xenografts into condyloma-like growths within athymic nude mice. here we describe detection of hpv-11 infection of neonatal human foreskin-derived keratinocytes, infected and cultured entirely in vitro, by use of the polymerase chain reaction and primers straddling the splice donor/acceptor site of the most preva ... | 1993 | 8396606 |
| benign leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of leser-trélat. | we present a case of a benign testicular leydig cell tumor and eruptive seborrheic keratosis associated with human papillomavirus type 33 infection. to our knowledge this is the first occurrence of a leydig cell tumor in a patient with tuberous sclerosis and the second documented case of eruptive seborrheic keratoses (sign of leser-trélat) associated with a benign neoplasm. | 1993 | 8396689 |
| human papillomavirus type 18 dna in so-called hep-2, kb and fl cells--further evidence that these cells are hela cell derivatives. | the contamination of hela cells into many culture cells has been suspected. we detected hpv type 18 dna in two hela cell sublines, hep-2 laryngeal cancer and kb oral cancer cell lines as well as fl cell line derived from normal amniotic membrane which have been extensively used so far in experimental virology. on the other hand, we detected hpv type 18 dna neither in other epithelial cell lines nor in fibroblastic human embryonic cells. the digestion analysis with several restriction enzymes of ... | 1993 | 8397027 |
| [a case of verrucous carcinoma of the penis with detection of human papillomavirus using the in situ hybridization method]. | a case of penile verrucous carcinoma is reported. the patient had a previous history of condyloma acuminatum of the penis. no signs of squamous cell carcinomas were observed in the histopathological findings. we also detected the histologic evidence of human papilloma virus (hpv) infection in the result of the study by in situ hybridization. the local positive reaction of hpv infection for type 6/11 was seen, and was related to the koliocytosis. however other types of hpv (16/18, 31/33, 51) were ... | 1993 | 8397482 |
| sexually transmitted diseases in adult, non-pregnant women. | most of the publications reviewed focus on human papillomavirus (hpv), and a small proportion on herpes simplex virus (hsv), chlamydia trachomatis, as well as the syndromes of pelvic inflammatory disease and bacterial vaginosis. the present hypothesis associates cervical intraepithelial neoplasia (cin)-1 with high oncogenic risk hpv types in less than 30% of cases; whereby cin-2 and cin-3 are associated with a 90% risk. however, on the basis of hpv types, four categories ['low risk' (hpv 6/11, 4 ... | 1993 | 8400052 |
| screening for human papillomavirus infections in esophageal squamous cell carcinomas by in situ hybridization. | infections with specific types of human papillomavirus (hpv) have been closely linked with human squamous cell carcinomas, those of the anogenital tract in particular. increasing number of reports also suggest that hpv infection could be a risk factor for esophageal cancer. however, most of the previous studies on hpv involvement in esophageal carcinomas have included only small numbers of biopsy specimens, thus necessitating additional studies based on extensive series of esophageal samples. | 1993 | 8402471 |
| [the treatment of cervical human papillomavirus (hpv) infection with trichloroacetic acid]. | ever since the alterations caused by the hpv on the cervix were discovered, countless treatments have been employed but the ideal method still remains unknown. the objective of the experiment was to assess the efficiency of handling the cervical infection caused by the hpv, by means of trichloroacetic acid, 85% rate. during the period comprised between april 1989 and march 1990, 60 patients were subject to close analysis. the general diagnosis drawn cytology, colposcopy, and histopathology was c ... | 1993 | 8406118 |
| study of the partners of women with human papillomavirus infection. | genital human papillomavirus (hpv) infection is one of the most common sexually transmitted diseases, and it has been identified as a significant risk factor for the development of dysplasia and cancer of the uterine cervix. the possible influence of male hpv lesions on female cervix oncogenesis has not been elucidated so far. in the present study we evaluate the male partners of women with clinical or subclinical hpv infection with particular interest in the clinical features of this infection ... | 1993 | 8407094 |
| human papillomavirus and cutaneous warts in meat handlers. | the association of papillomavirus and hand warts in meat handlers was examined. human papillomavirus (hpv) dna was found in 23 (88%) of 26 cutaneous warts, with hpv 7 (27%) and a yet unidentified hpv (hpv x) (42%) being the predominant types. hpv 2 was found in two (7.5%) patients, and hpv 4 was found in three (11.5%) patients. no bovine papillomavirus sequences were detected. in most patients, the warts developed in less than 2 years after they started working with meat. a possible hpv transmis ... | 1993 | 8408588 |
| an evaluation of oral ulcers in patients with aids and aids-related complex. | patients with hiv infection can have recurrent and persistent oral ulcers, not attributable to known infectious agents. | 1993 | 8408791 |
| evolution of human papillomavirus type 18: an ancient phylogenetic root in africa and intratype diversity reflect coevolution with human ethnic groups. | papillomaviruses are an ideal model system for the study of dna virus evolution. on several levels, phylogenetic trees of papillomaviruses reflect the relationship of their hosts. papillomaviruses isolated from remotely related vertebrates form major branches. one branch of human papillomaviruses (hpvs) includes an ape and two monkey papillomaviruses, possibly because the diversification of the viruses predated the separation of the infected-primate taxa. this hypothesis predicts that the root o ... | 1993 | 8411344 |
| mhc class i expression in hpv 16 positive cervical carcinomas is post-transcriptionally controlled and independent from c-myc overexpression. | squamous cell carcinomas of the uterine cervix (n = 23) were selected for the presence of human papillomavirus type 16 (hpv 16) using the polymerase chain reaction (pcr). localization of transcripts coding for the e7 protein was demonstrated in neoplastic cells with rna in situ hybridization. consecutive tissue sections were investigated for expression of the major histocompatibility complex class i (mhc-i) and c-myc using immunohistochemical double staining procedures, since a role has been sug ... | 1993 | 8414499 |
| low prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma in situ, invasive adenocarcinoma, and glandular dysplasia by polymerase chain reaction. | using the polymerase chain reaction on paraffin blocks for human papillomavirus (hpv) types 16 and 18, a positive result was seen in three of 20 cases of invasive adenocarcinoma, 15 of 36 cases of adenocarcinoma in-situ, and one of five cases of glandular dysplasia of the uterine cervix. types 16 and 18 were found with equal frequency. in adenocarcinoma in situ there was no age difference between hpv-positive and or hpv-negative cases. concomitant squamous dysplasia was slightly more frequent in ... | 1993 | 8415587 |
| transmission of human genital papillomavirus disease: comparison of data from adults and children. | a substantial body of evidence has demonstrated that the primary means of transmission of genital warts in sexually active adults is through sexual contact. however, the epidemiology and social significance of anal-genital warts in prepubertal children is controversial. debate continues regarding the frequency with which these lesions have resulted from sexual abuse or transmission by other means. an accurate understanding of the dominant means of transmission of anal-genital warts in children i ... | 1993 | 8416503 |
| an epidemiologic perspective on biomarkers. | the authors discuss biological markers from an epidemiologic perspective, emphasizing the importance of integrating biomarkers into large-scale observational and intervention studies. whereas any biologic phenomenon can be considered a biomarker, an intermediate end-point is defined as being on the causal pathway between exposure and disease. an intermediate end-point is a valid surrogate for a disease in relation to a given exposure if, and only if, that exposure causes a similar change in the ... | 1993 | 8429292 |
| bowenoid changes in kaposi's sarcoma. | previous reports have documented the coexistence of multiple infectious organisms or kaposi's sarcoma within the same biopsy specimens of mucocutaneous lesions in human immunodeficiency virus- (hiv) infected patients. | 1993 | 8454785 |
| electron microscopy visualization of oligonucleotide binding to duplex dna via triplex formation. | using biotinylated oligonucleotides and streptavidin as a marker, we have visualized, with the help of electron microscopy, the triplex formation. we used the natural homopurine-homopyrimidine sequence from human papillomavirus 16 cloned within a plasmid. under conditions favouring the formation of pyrimidine-purine-pyrimidine triplex the corresponding pyrimidine oligonucleotide formed a complex with the insert and this complex was detected by electron microscopy. similarly, under conditions fav ... | 1993 | 8464052 |
| verrucous carcinoma of the genital tract: is it a distinct entity? | between 1974 and 1985, 16 patients (7 men, 9 women) with a diagnosis of genital verrucous carcinoma were identified from the cancer registry of the tom baker cancer centre in calgary. all the men had lesions on the penis. in the women, five lesions were on the vulva, four were on the cervix and two were on the vagina (two women each had two involved sites). the histologic slides from the surgically excised specimens were reviewed, and, by applying strict criteria, all cases could be reclassified ... | 1993 | 8472225 |
| is hiv infection associated with an increase in the prevalence of cervical neoplasia? | to test the hypotheses: (1) that hiv infection predisposes to cervical intraepithelial neoplasia (cin); (2) that this cin is a result of hiv related immunosuppression; and (3) that this cin is a result of immunosuppression causing increased expression of the potentially oncogenic viruses, human papilloma virus (hpv), epstein barr virus (ebv) and herpes simplex virus (hsv). | 1993 | 8476807 |
| determinants of the geographic variation of invasive cervical cancer in costa rica. | the incidence of cervical cancer in costa rica is about twice as high in the coastal regions as in the interior. to study these regional variations, we used data from a 1986-1987 case-control study of 192 costa rican women with invasive cervical cancer and 372 controls. risk factors identified included the following: the study participant's (1) number of sexual partners, (2) age at first sexual intercourse, (3) number of live births, (4) presence of type 16/18 human papillomavirus (hpv) dna, (5) ... | 1993 | 8490673 |
| biological activities of p53 mutants in burkitt's lymphoma cells. | wild-type human p53 and a series of p53 point mutants isolated from burkitt's lymphoma (bl) cell lines were tested for their ability to inhibit dna synthesis in a p53-negative bl cell line and to bind and be degraded by the human papillomavirus type 16 e6 protein. all the mutants lost the wild-type ability to inhibit dna synthesis, demonstrating that they are all functionally altered. binding to e6 and consequent degradation of the p53 mutants frequently correlated with changed suppressor proper ... | 1993 | 8492087 |
| kaposiform hemangioendothelioma of infancy and childhood. an aggressive neoplasm associated with kasabach-merritt syndrome and lymphangiomatosis. | we report the clinical and pathological features of nine distinctive, but relatively unknown, vascular tumors of infancy and childhood presenting as soft tissue masses often associated with locally aggressive disease, lymphangiomatosis and kasabach-merritt syndrome. the patients, four males and five females, were all in their first decade of life except for two (median, 2 years; range, 5 months to 19 years). these tumors involved deep soft tissues of the upper extremity (four cases), retroperito ... | 1993 | 8494101 |
| the aetiology and risk factors for warts among poultry processing workers. | we conducted an investigation at a poultry processing plant in new zealand to estimate the prevalence of warts among workers and the risk of developing warts associated with specific work areas or individual work practices. we obtained information on demographic characteristics and self-reported medical and occupational histories from 88 (83%) of 106 permanent employees at the plant; almost half (39 people or 44%) had developed wart-like lesions on their arms or hands after they began working at ... | 1993 | 8505187 |
| the other epidemics. sexually transmitted diseases. | around 70% of female infertility in developing countries is caused by sexually transmitted diseases (stds) that can be traced back to husbands or partners. stds and reproductive tract infections cause 750,000 deaths and 75 million illnesses among women each year worldwide, and these deaths may more than double by the year 2000. death rates are rising fastest in africa, followed by asia and latin america. about 450,000 cases of potentially fatal reproductive tract cancers are diagnosed annuall ... | 1993 | 12159277 |
| a population-based seroepidemiological study of cervical cancer. | the epidemiology of cervical cancer indicates the presence of a sexually transmitted risk factor, attributable at least in part to infection with human papillomavirus (hpv) type 16 or 18. we performed a seroepidemiological study of hpv and cervical cancer in the counties of västerbotten and norrbotten in northern sweden, a low-risk area for cervical cancer. sera from 94 cases of incident cervical cancer were matched against 188 age- and sex-matched controls derived from a population-based blood ... | 1994 | 8261434 |
| prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients. | a study was performed to test the hypothesis that renal allograft recipients are at high risk of developing anal human papillomavirus (hpv) infection and anal intraepithelial neoplasia (ain). a total of 133 renal allograft recipients and 145 control patients underwent anoscopy and biopsy. a polymerase chain reaction was used to detect hpv16 dna in biopsy samples. a histological diagnosis of anal hpv infection or ain was made in 32 allograft recipients (hpv infection, five; ain i, 20; ain ii, thr ... | 1994 | 8173899 |
| interferon and retinoic acid suppress the growth of human papillomavirus type 16 immortalized cervical epithelial cells, but only interferon suppresses the level of the human papillomavirus transforming oncogenes. | in the present study, we examine the effects of all-trans-retinoic acid (ra) and interferons-alpha and -gamma (ifn-alpha and ifn-gamma) on the growth of hpv16-immortalized cell lines, ece16-1 and caski. treating proliferating ece16-1 cells with ra causes a concentration-dependent decrease in cell number. at 1 microm ra, cell growth is suppressed by 65% and the level of mrna encoding cytokeratin k5, a biochemical marker of retinoid action, is also suppressed. in contrast, the level of transcript ... | 1994 | 8174114 |
| analysis of hpv-positive and -negative vulvar carcinomas for alterations in c-myc, ha-, ki-, and n-ras genes. | mutation or overexpression of certain host genes, including c-myc, ha-ras, and ki-ras, have been associated with genital squamous neoplasia, specifically in the cervix, and have been implicated in the natural history of these tumors. the relationship of these host gene alterations to vulvar squamous cell carcinomas has not been previously studied. we analyzed archival material from 13 human papillomavirus-positive and -negative vulvar squamous cell carcinomas for mutations in ha-, ki-, and n-ras ... | 1994 | 8175026 |
| fast solid support detection of human papillomavirus in in vitro amplified dna using a dnp-anti dnp monoclonal antibody couple. | in some anogenital lesions the detection of certain types of human papilloma virus, especially oncogenic types, is of interest. in a first step during a prospective study, we compared two methods for the detection of human papillomavirus (hpv) dna in clinical samples: southern blotting followed by hybridization with a cloned radioactive genomic probe and a classical polymerase chain reaction (pcr) followed by hybridization with a 32p-labelled oligonucleotide probe. 118 biopsies and swabs were ex ... | 1994 | 8175945 |
| stomach cancer in transgenic mice expressing human papillomavirus type 16 early region genes from a keratin promoter. | certain human papillomaviruses (hpvs) have been implicated as important contributory factors in the development of cervical carcinoma and other epithelial malignancies. in order to investigate the role of papillomavirus early gene expression in epithelial oncogenesis in vivo, we produced transgenic mice expressing hpv-16 early region genes from the promoter of the bovine keratin 6 gene. spliced transcripts were detected in the tongue, forestomach, glandular stomach, female reproductive tract and ... | 1994 | 8176373 |
| development of a broad spectrum pcr assay for papillomaviruses and its application in screening lung cancer biopsies. | a pcr assay was developed to detect known and as yet unidentified papillomaviruses (pvs). for this purpose we analysed the conserved amino acid sequences in the l1 and e1 open reading frames of 45 human and nine animal pvs. candidate regions for the design of a primer were identified as those having the least number of amino acid and nucleotide sequence variants among the different pvs. these regions in the l1 orf have been described previously. we modified the sequences of the backward and the ... | 1994 | 8176375 |
| assembly of the major and the minor capsid protein of human papillomavirus type 33 into virus-like particles and tubular structures in insect cells. | native virions of human papillomaviruses (hpv) can be isolated from genital lesions only in very limited amounts. recent studies have shown that virus-like particles can be obtained by expression of the capsid proteins using vaccinia virus recombinants or the baculovirus system. we now present the first detailed characterization of virus-like particles of a human papillomavirus associated with malignant genital lesions, hpv-33, produced in high yield using the baculovirus expression system. asse ... | 1994 | 8178438 |
| cervical neoplasia in the patient with hiv infection. | with heterosexual transmission of hiv becoming the primary mode of transmission to women in the usa, and a high rate of human papillomavirus (hpv) and cervical neoplasia in hiv-infected women, obstetrician-gynecologists have become primary care providers for hiv-infected women. reports of a high rate of recurrence and progression of cervical neoplasia in this population suggest that gynecologists must strive to identify those women with cervical neoplasia who are hiv infected. alterations in loc ... | 1994 | 8180357 |
| association between hla-dqb1 alleles and risk for cervical cancer in african-american women. | squamous-cell carcinoma of the cervix and its precursor lesions are associated with human papillomavirus (hpv) infection. epidemiological studies indicate that hpv infection in itself is not sufficient for cervical-cancer induction, suggesting that other factors contribute to carcinogenesis. we have investigated the potential role of host genetic background as one such factor. we screened a series of squamous-cell carcinomas of the cervix for hla-class-ii dqb1* alleles by the polymerase chain re ... | 1994 | 8181853 |
| cationic liposomes mediated delivery of antisense oligonucleotides targeted to hpv 16 e7 mrna in caski cells. | the "high risk" types 16 and 18 of human papillomavirus (hpv) are involved in the etiology of genital squamous cell carcinoma. the early genes 6 and 7 (e6-e7) of these viruses code for the major transforming proteins, capable of inducing cell transformation alone or acting synergistically with other oncogenes. antisense oligonucleotides, recently applied to inhibit the functions of a number of cellular and viral proteins, might provide the basis for a new therapeutic strategy against hpv-induced ... | 1994 | 8147581 |
| sequence variation in the capsid protein genes of human papillomavirus type 16. | we have cloned and sequenced the l1 and l2 genes from human papillomavirus type 16 (hpv16) dna-containing cervical cytology samples collected from the u.k. and trinidad. samples containing high copy numbers of hpv16 dna were selected as being likely to contain fully functional virus dna molecules in an episomal state, rather than in an integrated and possibly altered state. in comparison with the previously published sequence of hpv16 isolated from an invasive cancer a variety of differences wer ... | 1994 | 8151305 |
| [analysis of p53 gene in gynecologic tumors]. | the inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. herein, we performed a p53 gene analysis of human gynecologic tumor cell lines and tumor tissues. in the sk-ov-3 cell line, southern analysis suggested the presence of sequence deletions/rearrangements in at least one allele of p53 gene. transcripts were not detectable by either northern or pcr analysis. sequencing analysis of the entire coding region revealed mutations changing the p53 amino ac ... | 1994 | 8152158 |
| local epidermal viral infections: comparative aspects of vaccinia virus, herpes simplex virus and human papillomavirus in man and orf virus in sheep. | 1994 | 8156048 | |
| human cytotoxic t lymphocytes stimulated by endogenously processed human papillomavirus type 11 e7 recognize a peptide containing a hla-a2 (a*0201) motif. | cytotoxic t lymphocytes (ctl) may play an important role in the control of human papillomavirus (hpv)-induced anogenital neoplasias, but have been difficult to study owing to the difficulty in obtaining sufficient quantities of infectious virus. to address this we have stimulated human hpv-specific ctl in vitro using low-density cells (ldc) from peripheral blood mononuclear cells (pbmc). low-density cells were used to present synthetic peptides, or endogenously processed peptides expressed from ... | 1994 | 8157270 |
| detection of human papillomaviruses in paraffin-embedded biopsies of cervical intraepithelial lesions: analysis by immunohistochemistry, in situ hybridization, and the polymerase chain reaction. | one hundred and forty biopsies with an initial diagnosis of cervical intraepithelial lesion (cil) were tested for the presence of human papillomavirus (hpv) by immunohistochemistry and in situ hybridization using commercial biotinylated probes (vira-type in situ assay; digene diagnostics, silver spring, md) or probes labeled with digoxigenin by the random primer technique. immunohistochemistry was more inferior to the in situ hybridization method, with a detection rate of 14% (20/140) compared t ... | 1994 | 8159640 |
| absence of human papilloma virus dna in oropharyngeal spindle-cell squamous carcinomas. | the presence of human papilloma virus (hpv) dna in verrucous carcinomas and some squamous-cell carcinomas (scc) of the oropharynx suggests a role for the virus in their pathogenesis. spindle-cell squamous carcinoma is an uncommon variant of oropharyngeal scc. its association with the hpv has not been reported. in situ and dot blot hybridization, using biotinylated probes to hpv 6, 11, 16, 18, 31, 33, and 35, failed to detect hpv dna in nine studied cases of spindle-cell squamous carcinoma, as di ... | 1994 | 8160645 |
| the prevalence of cervical infection with human papillomaviruses and cervical dysplasia in alaska native women. | alaska native women historically have high rates of sexually transmitted diseases (stds) and invasive cervical cancer. their prevalence of cervical infections with human papillomavirus (hpv) in relation to cervical dysplasia was determined with a commercial dot hybridization test for seven hpv genotypes. type-specific hpv dna, similarly distributed between genotype groups 16/18 and 31/33/35, was detected in 234 cervical specimens (21%) from 1126 alaska native women seeking routine care and colpo ... | 1994 | 8133094 |
| a virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. | previous studies have demonstrated that genital infection with high-risk types of human papillomavirus (hpv), most often hpv16, is the most significant risk factor for the development of cervical cancer. however, serologic assays that have been developed to identify high-risk hpv infection have either failed to associate serum reactivity with other indicators of hpv infection or have identified only a minority of hpv-infected individuals. | 1994 | 8133532 |
| transitional cell carcinoma of fossa navicularis in a man with three other synchronous malignancies. | transitional cell carcinoma arising from the anterior portion of the male urethra is rare, with less than 10 cases reported in the literature. our patient had a high-grade, highly invasive transitional cell carcinoma originating in the fossa navicularis and extending proximally along the corpus spongiosum, the corpora cavernosa, and blood and lymphatic vessels. in addition, the patient had a concurrent low-grade prostatic adenocarcinoma, a large basal cell carcinoma of the nose, and a squamous c ... | 1994 | 8116126 |
| genital herpes simplex virus and human papillomavirus infection. | 1994 | 8123227 |