Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| toll-like receptor 2 (tlr) -196 to 174del polymorphism in gastro-duodenal diseases in japanese population. | toll-like receptors (tlrs) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. -196 to -174del polymorphism affects the tlr2 gene and alters its promoter activity. we investigated the influence of tlr2 -196 to -174del polymorphism on the risk of gastro-duodenal diseases, on the severity of helicobacter pylori-induced gastritis in a japanese population. the study was performed on 309 patients with abdominal discomfort ... | 2008 | 17934843 |
| periodontitis may increase the risk of peripheral arterial disease. | the aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (pad). | 2008 | 17964192 |
| dynamic colonization of helicobacter pylori in human gastric mucosa. | to investigate the dynamic behaviour of helicobacter pylori in the colonization of the human gastric mucosa in patients previously treated for h. pylori infection. | 2008 | 17918004 |
| altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine helicobacter infection. | matrix metalloproteinases (mmps) have roles in inflammation and other processes relevant to the architectural disturbances seen in the gastric mucosa in response to helicobacter pylori infection. upregulation of mmps has been reported in h pylori infection, but there are no detailed reports regarding altered production of their inhibitors, the tissue inhibitors of metalloproteinases (timps). | 2008 | 17412866 |
| association of helicobacter pylori and epstein-barr virus with gastric cancer and peptic ulcer disease. | helicobacter pylori and epstein-barr virus (ebv) infections are common world-wide. though h. pylori infection is a major factor in gastroduodenal diseases, its role in association with ebv infection is unknown. we prospectively studied the association of h. pylori and ebv in patients with gastric cancer (gc) and peptic ulcer disease (pud). | 2008 | 18569983 |
| the role of infectious agents in the etiology of ocular adnexal neoplasia. | given the fact that infectious agents contribute to around 18% of human cancers worldwide, it would seem prudent to explore their role in neoplasms of the ocular adnexa: primary malignancies of the conjunctiva, lacrimal glands, eyelids, and orbit. by elucidating the mechanisms by which infectious agents contribute to oncogenesis, the management, treatment, and prevention of these neoplasms may one day parallel what is already in place for cancers such as cervical cancer, hepatocellular carcinoma ... | 2008 | 18572051 |
| effects of different helicobacter pylori culture filtrates on growth of gastric epithelial cells. | to study the effects of different helicobacter pylori (h pylori) culture filtrates on growth of gastric epithelial cells. | 2008 | 18595143 |
| cross-reactivity between immune responses to helicobacter bilis and helicobacter pylori in a population in thailand at high risk of developing cholangiocarcinoma. | helicobacter bilis dna has been detected in human tissue and is a candidate for etiologic investigations on the causes of hepatic and biliary tract diseases, but reliable serologic tests need to be developed in order to pursue such investigations. the scope of this study was to assess the specificity of two assays for h. bilis immune response allowing for h. pylori, and their cross-reactivity in a population in thailand at high risk for cholangiocarcinoma. plasma samples from 92 thai volunteers ... | 2008 | 18596203 |
| loss of imprinting of igf2 and h19, loss of heterozygosity of igf2r and ctcf, and helicobacter pylori infection in laryngeal squamous cell carcinoma. | imprinting analyses of igf2 and h19, loss of heterozygosity (loh) analyses of igf2r and ctcf and helicobacter pylori detection, were performed on 35 human laryngeal squamous cell carcinomas (lscc). forty-six percent of the tumors were heterozygous for igf2, and 54% were informative for the h19. biallelic expression of igf2 was observed in 33% (5 out of 15) of the tumors and in 27% (4 out of 15) of adjacent non-tumorous laryngeal tissues. h19 loss of imprinting (loi) was observed in 24% (4 out of ... | 2008 | 18604514 |
| gg genotype of cyclin d1 g870a polymorphism is associated with non-cardiac gastric cancer in a high-risk region of china. | cyclin d1 (ccnd1) is a regulatory protein involved in the cell cycle of both normal and neoplastic cells. polymorphism of this gene at codon 242 in exon 4 (a870g) has an impact on the risk of several human cancers. the purpose of this study was to study the relation between the ccnd1 a870g gene polymorphism and the risk of non-cardiac gastric cancer in a chinese population. | 2008 | 18609126 |
| [decrease of the prevalence of helicobacter pylori infection in the czech republic]. | helicobacter pylori (hp) is the most common chronic bacterial infection in humans. hp has been demonstrated worldwide and in individuals of all ages. the overall prevalence of hp infection has fallen dramatically in the czech republic over recent 15 years (from 70% in 1993 to 35% in 2006). this decrease can be explained mostly by the relatively favourable and improving socioeconomic conditions after the fall of communist regime. however, it is necessary to consider also the fundamental determina ... | 2008 | 18630179 |
| helicobacter pylori produces unique filaments upon host contact in vitro. | helicobacter pylori exists in 2 distinct morphological states, helicoid and coccoid. both have been observed in in vitro culture and in gastric biopsies. we visualized h. pylori during ags cell infections using immunofluorescence microscopy. anti-h. pylori mouse serum as well as human serum from h. pylori-positive patients recognized long, thin bacterial filaments, which formed on helicoids and more frequently on coccoids. these filaments reached lengths of 59 microm and often connected bacteria ... | 2008 | 18641700 |
| transgenic expression of helicobacter pylori caga induces gastrointestinal and hematopoietic neoplasms in mouse. | infection with caga-positive helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (malt) lymphoma of b cell origin. the caga-encoded caga protein is delivered into gastric epithelial cells via the bacterial type iv secretion system and, upon tyrosine phosphorylation by src family kinases, specifically binds to and aberrantly activates shp-2 tyrosine phosphatase, a bona fide oncoprotein in human malignancies. caga also elicits junctional and ... | 2008 | 18192401 |
| helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2. | recently, it has been shown that serine proteases derived from microorganisms stimulate epithelial cells to produce inflammatory mediators through protease-activated receptor (par). we investigated the involvement of par2 in the interleukin (il)-8 production by helicobacter pylori-infected gastric epithelial cells. | 2008 | 18196899 |
| helicobacter pylori protein response to human bile stress. | the ability of helicobacter pylori to tolerate bile is likely to be important for its colonization and survival in the gastrointestinal tract of humans. as bile can be acidified after reflux into the low ph of the human stomach, the inhibitory effect of fresh human bile with normal appearance on h. pylori before and after acidification was tested first. the results showed that acidification of bile attenuated its inhibitory activity towards h. pylori. next, the protein profiles of h. pylori unde ... | 2008 | 18201979 |
| discovering differential protein expression caused by caga-induced erk pathway activation in ags cells using the seldi-proteinchip platform. | to identify the protein expression differences related to the caga-induced erk pathway activation in ags cells. | 2008 | 18203287 |
| long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment. | gastric mucosa-associated lymphoid tissue (malt) lymphoma is characterized by multifocality of the tumors, which often scatter over the mucosa of the stomach and adjacent upper gastrointestinal tract, and is therefore theoretically not curable by surgical resection. | 2008 | 18216531 |
| chronic active gastritis in x-linked lymphoproliferative disease. | gastric lesions in primary constitutive immune deficiencies include multifocal atrophic gastritis, erosive pangastritis, and a pattern of gastric lesions reminiscent of graft-versus-host disease. we describe the genetic anomalies in 2 monozygotic twins with an x-linked lymphoproliferative disease (xlp; mim 308240), a rare familial setting of high susceptibility to epstein-barr virus (ebv). since early childhood, both twin brothers exhibited a severe chronic active atrophic pangastritis. a germli ... | 2008 | 18223336 |
| chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ hybridization study using a tissue microarray approach. | extranodal marginal zone b-cell lymphomas (mucosa-associated lymphoid tissue [malt] lymphomas) of the gastrointestinal tract have been known to have characteristic chromosomal aberrations including trisomies of chromosomes 3, 12, and 18. however, knowledge of the clinical significance of cytogenetic changes in malt lymphomas is still limited. in the present study, the frequency of the numeric and structural aberrations of the chromosomes 1, 3, 12, 18 and x and of the malt1 gene as well as their ... | 2008 | 18234275 |
| h pylori (caga) and epstein-barr virus infection in gastric carcinomas: correlation with p53 mutation and c-myc, bcl-2 and bax expression. | to investigate the interrelationship between h pylori and epstein-barr virus (ebv) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-myc, bcl-2 and bax expression. | 2008 | 18240345 |
| effects of helicobacter pylori infection on gastric mucin expression. | this study was performed to determine the gastric distributions of muc5ac and muc6 depending on helicobacter pylori (h. pylori) infection, and to evaluate whether the expressions of muc5 and muc6 change in h. pylori-associated gastroduodenal diseases. in addition, muc5ac and muc6 expressional changes were investigated before and after h. pylori eradication. | 2008 | 18097286 |
| role of toll-like receptors in gastrointestinal malignancies. | mounting evidence supports the tenet that innate immune responses to luminal microbes participate in the development of gastrointestinal malignancies. the gastrointestinal tract is relatively unique in that it has evolved in the presence of diverse enteric microflora. intestinal flora is required to develop a normal adaptive immune response in the periphery. with the characterization of the innate immune system, we have begun to understand the adaptations the intestine has made to the microbiota ... | 2008 | 18176605 |
| polymorphisms in toll-like receptor genes and risk of cancer. | host genetic factors are emerging as key determinants of disease risk for many cancers. identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. the toll-like receptors are important members of the host's innate immune response and their genes have been found to be polymorphic. this genetic variation allows for a more intricate repertoire that enables the host to withstand microbial challenges. while this may be advant ... | 2008 | 18176606 |
| il-4 -588c>t polymorphism and il-4 receptor alpha [ex5+14a>g; ex11+828a>g] haplotype concur in selecting h. pylori caga subtype infections. | the th2 cytokine il-4 might limit h. pylori associated gastric inflammation and favour h. pylori clearance. the aim of the study was to verify whether il-4 -588c>t snp, or two snps of the gene coding the alpha chain of il-4 receptor (il-4ra ex5+14a>g, il-4ra ex11+828a>g) considered singly or as haplotypes, are correlated with h. pylori virulence genes or h. pylori associated diseases. | 2008 | 18179773 |
| [gastric lymphoma. morphological and immunohistochemical study]. | most of extranodal lymphomas are localized in gastrointestinal tract, gastric lymphoma representing more than 50% of them. the role that helicobacter pylori (h. pylori) plays in pathogenesis of gastric lymphoma has changed the therapeutic approach. | 2008 | 18677925 |
| expression, purification, crystallization and preliminary x-ray analysis of an nad-dependent glyceraldehyde-3-phosphate dehydrogenase from helicobacter pylori. | helicobacter pylori is a dangerous human pathogen that resides in the upper gastrointestinal tract. little is known about its metabolism and with the onset of antibiotic resistance new treatments are required. in this study, the expression, purification, crystallization and preliminary x-ray diffraction of an nad-dependent glyceraldehyde-3-phosphate dehydrogenase from h. pylori are reported. | 2008 | 18678942 |
| targeting focal adhesions:helicobacter pylori-host communication in cell migration. | abstract: highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. the human pathogen helicobacter pylori (h. pylori) directly targets integrins with drastic consequences on the epithelial cell morphology and migration, which might contribute to the disruption of the gastric epithelium in vivo. in this review, we summarize the recent findings concerning the complex mechanism through ... | 2008 | 18684322 |
| cyp2c19 genotypes and helicobacter pylori eradication. | 2008 | 18699976 | |
| multiple early gastric cancer with gastritis cystica profunda showing various histological types. | we report a case of multiple early gastric cancer showing varied histological types associated with gastritis cystica profunda (gcp). a 61-year-old man who had early gastric cancer associated with gcp underwent a distal gastrectomy with lymphadenectomy. histological examination showed various histological types of cancer -well differentiated, moderately differentiated, poorly differentiated adenocarcinoma, mucinous adenocarcinoma and signet ring cell carcinoma- that had developed independently i ... | 2008 | 18705349 |
| molecular expression of gastrokine 1 in normal mucosa and in helicobacter pylori-related preneoplastic and neoplastic gastric lesions. | we have analyzed the expression of gastrokine 1 (gkn1), one of the most abundant protein of gastric mucosa, in helicobacter pylori-related preneoplastic and neoplastic gastric lesions. the gkn1 expression was downregulated in 36 h. pylori-positive patients with respect to 29 h. pylori-negative subjects as evaluated by western blot, reverse transcriptase polymerase chain reaction (rt-pcr) and immunohistochemistry, showing a progressive decrease from chronic gastritis to atrophy and intestinal met ... | 2008 | 18927498 |
| effective prevention and treatment of helicobacter pylori infection using a combination of catechins and sialic acid in ags cells and balb/c mice. | the increasing emergence of helicobacter pylori strains resistant to antibiotics may cause unsuccessful treatment. an alternative agent or mixture with anti-h. pylori effect is urgently required to reduce h. pylori infection. we explored the preventive and therapeutic potential of a combination of catechins and sialic acid on h. pylori-infected human gastric cells in vitro and in mice in vivo. we evaluated the anti-h. pylori activity of catechins and/or sialic acid using the agar dilution and ch ... | 2008 | 18936202 |
| a case of cronkhite-canada syndrome: remission after treatment with anti-helicobacter pylori regimen. | a 67-year-old man with nausea, appetite loss, frequent diarrhea and severe weight loss presented with alopecia, skin hyperpigmentation and onychodystrophy. laboratory investigations showed mild anemia, hypoproteinemia and hypoalbuminemia. colonoscopy identified the numerous, hyperemic and sessile polyps with mucous exudation of various sizes throughout the colorectum. the ileocecal valve was substantially swollen. magnified chromoendoscopy revealed sparsely distributed crypt openings with wideni ... | 2008 | 18948692 |
| [establishment of mongolian gerbil model of long-term helicobacter pylori infection]. | to establish a model of long-term infection with helicobacter pylori (hp) in mongolian gerbil (meriones unguiculatus), and to investigate if hp combined with n-methyl-n'-nitro-n-nitrosoguanidine (mnng) has a synergistic effect to induce gastric mucosa injury. to investigate pathological changes of gastric mucosa during long-term hp infection in mongolian gerbil model. | 2008 | 18956630 |
| [effects of tumor necrosis factor-alpha inducing protein-alpha secreted by helicobacter pylori on human gastric epithelial cells]. | to investigate the effects of tumor necrosis factor-alpha-inducing protein-alpha (tipalpha) released from helicobacter pylori (hp) on human gastric epithelial cells. | 2008 | 18956632 |
| aetiology of cancer in asia. | cancer has become the leading cause of death in many asian countries. there is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. in this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in asian populations. infectious agents such ... | 2008 | 18990005 |
| infectious agents and colorectal cancer: a review of helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus. | based on the high volume of bacteria and viruses that the intestine is exposed to and the importance of infectious agents in some gastrointestinal and anogenital cancers, it is not surprising the many studies have evaluated the association between colorectal cancer and infectious agents. this review highlights investigations of four agents in relation to colorectal cancer. helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus have all been evaluated as possible etiologic a ... | 2008 | 18990738 |
| helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. | the human pathogen helicobacter pylori influences cell adhesion, proliferation, and apoptosis and is involved in gastric adenocarcinoma formation. in our study we analyzed the impact of h. pylori infection on the regulation of beta-catenin, which plays a central role in both cell adhesion and tumorigenesis. infection of madin-darby canine kidney cells with h. pylori led to suppression of ser/thr phosphorylation and ubiquitin-dependent degradation of beta-catenin and to up-regulation of lymphoid ... | 2008 | 18772141 |
| recombination-based in vivo expression technology identifies helicobacter pylori genes important for host colonization. | here we undertook to identify colonization and gastric disease-promoting factors of the human gastric pathogen helicobacter pylori as genes that were induced in response to the stomach environment. using recombination-based in vivo expression technology (rivet), we identified six promoters induced in the host compared to laboratory conditions. three of these promoters, designated pivi10, pivi66, and pivi77, regulate genes that h. pylori may use to interact with other microbes or the host. pivi10 ... | 2008 | 18794279 |
| helicobacter pylori protein hp0175 transactivates epidermal growth factor receptor through tlr4 in gastric epithelial cells. | the pathophysiology of helicobacter pylori-associated gastroduodenal diseases, ulcerogenesis, and carcinogenesis is intimately linked to activation of epidermal growth factor receptor (egfr) and production of vascular endothelial growth factor (vegf). extracellular virulence factors, such as caga and vaca, have been proposed to regulate egfr activation and vegf production in gastric epithelial cells. we demonstrate that the h. pylori secretory protein, hp0175, by virtue of its ability to bind tl ... | 2008 | 18806258 |
| evaluation of the clinical significance of homb, a novel candidate marker of helicobacter pylori strains associated with peptic ulcer disease. | homb codes for a putative helicobacter pylori outer membrane protein and has previously been associated with peptic ulcer disease (pud) in children. | 2008 | 18811585 |
| hancornia speciosa: indications of gastroprotective, healing and anti-helicobacter pylori actions. | mangaba (hancornia speciosa gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomach ache. | 2008 | 18761076 |
| causality and gastrointestinal infections: koch, hill, and crohn's. | the gastrointestinal tract contains a complex mix of microorganisms. therefore, the finding of a particular microbe in the gastrointestinal tract or stools of a patient with intestinal disease does not necessarily indicate that the clinical state resulted from the presence of this organism. for this reason, extending from epidemiological association to causality is particularly challenging for gastrointestinal diseases. most established agents of acute bacterial gastroenteritis (eg, escherichia ... | 2008 | 18992408 |
| role of the gastrin-gastrin receptor system in the expansive growth of human gastric neoplasms. | gastrin is one of the most important gut hormones. however, the role of the gastrin-gastrin receptor (gr) system in the growth of gastric tumors is still unclear. | 2008 | 19065055 |
| [the change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of helicobacter pylori]. | the cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase (inos), the proteins that have the role in the gastric carcinogenesis, are stimulated by h. pylori infection in the gastric mucosa. the aim of this study was to evaluate the expression of cox-2 and inos proteins one year after the eradication of h. pylori. | 2008 | 19077474 |
| novel single nucleotide polymorphism of the vegf gene as a risk predictor for gastroduodenal ulcers. | the gastroduodenal ulcer (gdu) mostly develops on the lesser curvature side of stomach and the anterior wall of duodenal bulb, irrespective of the etiologies including helicobacter pylori infection, non-steroidal anti-inflammatory drugs, alcohol, etc. however, a clear explanation as to why ulcers are prevalent in these areas has still not been given. the current study was designed to evaluate whether the vascular endothelial growth factor (vegf) polymorphism could predict susceptibility to gdu t ... | 2008 | 19120886 |
| expression of inducible nitric oxide synthase and nitric oxide-modified proteins in helicobacter pylori-associated atrophic gastric mucosa. | induction of inducible nitric oxide synthase (inos) may be involved in carcinogenesis of the stomach, because nitric oxide (no) derived from inos can exert dna damage and post-transcriptional modification of target proteins. in the present study, we investigated the correlation between endoscopic findings and inos mrna expression/no-modified proteins in the gastric mucosa. | 2008 | 19120907 |
| the influence of the eradication of helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease. | helicobacter pylori (h. pylori) infection has been known to influence the gastric leptin and ghrelin secretion, for which the exact pathogenic role has not been documented yet. this study was designed to investigate the influence of h. pylori eradication on plasma or gastric levels of ghrelin, body mass index (bmi), and resultant levels of appetite in patients with peptic ulcer disease. | 2008 | 19120912 |
| mosaic dna imports with interspersions of recipient sequence after natural transformation of helicobacter pylori. | helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. h. pylori is naturally competent for transformation by exogenous dna, and recombination during mixed infections of one stomach with multiple h. pylori strains generates extensive allelic diversity. we developed an in vitro transformation protocol to study genomic imports after natural transformation of h. pylori. the mean length of imported fragments was dependent on the combi ... | 2008 | 19030104 |
| interaction between cd14-159c>t polymorphism and helicobacter pylori is associated with serum total immunoglobulin e. | total serum ige is regulated by both environmental and genetic factors. association and linkage studies have suggested a role of cd14-159c>t polymorphism in the regulation of serum total ige, but the results have been contradictory. it seems that gene-environment interactions are involved in this regulation. | 2008 | 19037967 |
| h. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. | our previous study of helicobacter pylori-induced apoptosis showed the involvement of bcl-2 family proteins and cytochrome c release from mitochondria. here, we examine the release of other factors from mitochondria, such as apoptosis-inducing factor (aif), and upstream events involving caspase-8 and bid. | 2008 | 19166416 |
| [correlation of helicobacter pylori infection with the expression of cox-2 and egfr and vegf in human gastric carcinoma]. | to investigate the correlation of helicobactor pylori (hp) infection with the expression of cox-2, egfr and vegf in human gastric carcinoma. | 2008 | 19173907 |
| [assessment of rate of hydroxyl anions production by helicobacter pylori in stomach]. | production of hydroxyl anions by tissue samples of pylorus mucous membrane obtained from 45 patients with gastric or duodenal ulcers was investigated. the production was estimated using the recently developed method based on measurement of rate of ph change in urea-containing reaction mixture. the rate of [oh-] generation as a result of h. pylori metabolism accounted on pylorus square varied from 0.4 to 1318.9 mcmol [oh-]/min, and in 90.2% of cases it did not exceed 128.1 mcmol [oh-]/min. this r ... | 2008 | 19004294 |
| effect of helicobacter pylori eradication on oncogenes and cell proliferation. | helicobacter pylori , the main cause of chronic gastritis, is a class 1 gastric carcinogen. however, it remains unclear whether h. pylori affects molecular alterations in chronic gastritis. thus, this study was designed to investigate the effect of h. pylori eradication on the expression of human telomerase rna (htr), human telomerase reverse transcriptase (htert), c-myc and proliferation nuclear cell antigen (pcna) in h. pylori associated chronic gastritis. | 2008 | 18837738 |
| relevance of helicobacter pylori virulence factors for vaccine development. | helicobacter pylori infection increases the risk for a wide spectrum of clinical outcomes, ranging from peptic ulcer disease to gastric cancer. however, the infection induces gastric and duodenal ulceration or gastric cancer in only a minority of infected subjects because h. pylori strains are genetically diverse and express different virulence factors. individuals infected with strains that express these virulence factors probably develop severe diseases such as gastric cancer. nevertheless, th ... | 2009 | 20464218 |
| [carcinogenic mechanisms of helicobacter pylori]. | 2009 | 21089532 | |
| helicobacter pylori: pathological mechanism involved in gastric colonization. | since 1982, when marshall and warren highlighted the presence of h. pylori at the apical pole of the epithelial gastric cells, the medical literature has registered a cascade of subsequent researches concerning this amazing bacterium, its action on the human body and the body response. the apogee of these studies and conclusions about the pathogenic role of hp was touched with its certain recognition as class one carcinogenic agent (peura 1997, who), becoming the first bacteria with such an acti ... | 2009 | 21179915 |
| h. pylori selectively blocks egfr endocytosis via the non-receptor kinase c-abl and caga. | helicobacter pylori infection is a primary cause of peptic ulcers and is associated with gastric carcinogenesis. the h. pylori-induced pathophysiology may be linked to the deregulation of egfr signalling. elevated mucosal levels of egf and the egfr have been found in antral gastric biopsies of h. pylori-infected patients. a critical mechanism for regulating egfr signalling is ligand-induced endocytosis. the internalized receptor recycles back to the plasma membrane for continued signalling or is ... | 2009 | 19016792 |
| a genetic variant of the p22phox component of nadph oxidase c242t is associated with reduced risk of functional dyspepsia in helicobacter pylori-infected japanese individuals. | although inflammatory changes in the gastric mucosa are commonly observed in japanese patients with functional dyspepsia (fd), detailed data regarding the relationship between the genetic regulatory factors of inflammation and fd are not available. superoxide has been implicated in the pathogenesis of helicobacter pylori-related diseases through inflammation. nicotinamide adenine dinucleotide phosphate oxidase, a major source of superoxide generation plays a critical role in h. pylori-related ga ... | 2009 | 19531958 |
| cross-talk between inducible nitric oxide synthase and cyclooxygenase in helicobacter-pylori-induced gastritis. | the present study examined the cross-talk between prostanoids and nitric oxide (no) in human gastric biopsies during helicobacter pylori infection. | 2009 | 19797925 |
| muc1 limits helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. | the bacterium helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and malt lymphoma. the cell-surface mucin muc1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of h. pylori in a murine infection model. we now demonstrate that by using the baba and saba adhesins, h. pylori bind muc1 isolated from human gastric cells and muc1 shed into gastric juice. both h. pylori carrying these adhesins, and beads coated with muc1 antibodies ... | 2009 | 19816567 |
| genetic factors associated with intestinal metaplasia in a high risk singapore-chinese population: a cohort study. | intestinal metaplasia (im) is an important precursor lesion in the development of gastric cancer (gc). the aim of this study was to investigate genetic factors previously linked to gc risk for their possible association with im. a total of 18 polymorphisms in 14 candidate genes were evaluated in a singapore-chinese population at high risk of developing gc. | 2009 | 19822020 |
| helicobacter pylori hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo. | helicobacter pylori-derived peptide rpl1 aa 2-20 (hp(2-20)) in addition to its antimicrobial action exerts several immunomodulatory effects in eukaryotic cells by interacting with formyl peptide receptors (fprs). it has recently been shown that activation of fprs facilitates intestinal epithelial cell restitution. we investigated whether hp(2-20) induces healing of injured gastric mucosa and assessed the mechanisms underlying any such effect. we investigated the expression of fprs in two gastric ... | 2009 | 19692643 |
| promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions. | promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. to date, several reports on methylation of various genes in gastric cancer have been published. however, most of these studies have focused on cancer tissues or only a single gene. in this study, we determined the methylation frequency of 5 genes, including p16, runx3, mgmt, dapk, and rassf1a, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin- ... | 2009 | 19695681 |
| helicobacter pylori sequences reflect past human migrations. | the long association between the stomach bacterium helicobacter pylori and humans, in combination with its predominantly within-family transmission route and its exceptionally high dna sequence diversity, make this bacterium a reliable marker for discerning both recent and ancient human population movements. as much of the diversity in h. pylori sequences is generated by recombination and mutation on a local scale, the partitioning of h. pylori sequences from a large globally distributed data se ... | 2009 | 19696494 |
| helicobacter pylori typing as a tool for tracking human migration. | helicobacter pylori strains from different geographic areas exhibit clear phylogeographical differentiation; therefore, the genotypes of h. pylori strains can serve as markers for the migration of human populations. currently, the genotypes of two virulence factors of h. pylori, caga and vaca, and multilocus sequence typing (mlst) are widely used markers for genomic diversity within h. pylori populations. there are two types of caga: the east asian type and the western type. in addition, the rig ... | 2009 | 19702588 |
| effect of helicobacter pylori eradication on incidence of gastric cancer in human and animal models: underlying biochemical and molecular events. | gastric cancer remains one of the most common cancers worldwide. a strong association exists between helicobacter pylori infection and the risk of developing noncardia gastric cancer. h. pylori eradication by antibiotic treatment is regarded as a primary chemoprevention strategy to reduce gastric cancer incidence. | 2009 | 19702845 |
| evidence for transepithelial dendritic cells in human h. pylori active gastritis. | despite extensive experimental investigation stressing the importance of bacterial interaction with dendritic cells (dcs), evidence regarding direct interaction of helicobacter pylori or its virulence products with dcs in the human gastric mucosa is lacking. | 2009 | 19702851 |
| helicobacter pylori moves through mucus by reducing mucin viscoelasticity. | the ulcer-causing gastric pathogen helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. h. pylori survives in acidic conditions by producing urease, which catalyzes hydrolysis of urea to yield ammonia thus elevating the ph of its environment. however, the manner in which h. pylori is able to swim through the viscoelastic mucus gel that coats the stomach wall remains poorly understood. previous rheology studies on gastric mucin, the key vi ... | 2009 | 19706518 |
| neutrophil gelatinase-associated lipocalin (ngal/lcn2) is upregulated in gastric mucosa infected with helicobacter pylori. | helicobacter pylori infection is one of the most significant risk factors for gastric cancer. the infection is established early in life and persists lifelong leading to a sustained chronic inflammation. iron is essential for most living organisms. bacteria use several mechanisms to acquire iron from their hosts, including the synthesis of the potent iron chelators known as siderophores. hosts cells may express the siderophore-binding protein neutrophil gelatinase-associated lipocalin (ngal/lipo ... | 2009 | 19727808 |
| geographic distribution of methyltransferases of helicobacter pylori: evidence of human host population isolation and migration. | helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. this ubiquitous association between h. pylori and humans is thought to be present since the origin of modern humans. the h. pylori genome encodes for an exceptional number of restriction and modifications (r-m) systems. to evaluate if r-m systems are an adequate tool to determine the geographic distribution of h. pylori strains, we typed 221 strains from africa, america, asia, and ... | 2009 | 19737407 |
| efficacy of passive immunization with igy antibodies to a 58-kda h. pylori antigen on severe gastritis in balb/c mouse model. | consecutive triple doses of 1 x 10(8) cfu/ml of a pathogenic h. pylori strain isolated from stomach of egyptian patients with severe gastritis were used to establish infection in balb/c mice model. white leghorn hens were immunized with h. pylori whole cell lysate (hplysate) antigen and with a highly reactive 58-kda h. pylori (hp58) antigen. two months later, igy antibodies (igy-hplysate & igy-hp58) were purified from egg yolk and its efficacy was evaluated in the adopted model. microbiological ... | 2009 | 19739011 |
| interaction of helicobacter pylori with genetic variants in the mdm2 promoter, is associated with gastric cancer susceptibility in chinese patients. | mdm2 is a major negative regulator of p53, and a single nucleotide polymorphism (snp) in the mdm2 promoter region snp309 (rs2279744) has been shown to increase the affinity of the transcriptional activator sp1, resulting in elevated mdm2 transcription and expression in some cancers. the aim of this study was to determine whether snp309 is associated with susceptibility to gastric cancer in chinese patients. | 2009 | 19751436 |
| methylation of p16ink4a and mitotic arrest defective protein 2 (mad2) genes in gastric marginal-zone b-cell lymphomas. | products of cyclin-dependent kinase inhibitor p16(ink4a)and mitotic arrest defective protein 2 (mad2) genesare key regulator proteins at the g1 restriction point and mitotic checkpoint of the cell cycle. the objective of this study was to investigate the role of promoter methylation of p16(ink4a) and mad2 genes in gastric marginal-zone b-cell lymphoma (mzbcl). | 2009 | 19174606 |
| cross-reaction of antibody against helicobacter pylori urease b with platelet glycoprotein iiia and its significance in the pathogenesis of immune thrombocytopenic purpura. | many clinical investigations have suggested that helicobacter pylori (h. pylori) infection might be associated with immune thrombocytopenic purpura (itp), but its role in the pathogenesis of itp is unsettled. in this study, we cultured h. pylori, produced recombinant h. pylori urease (ure) b, and then prepared monoclonal antibody (moab) against ureb, 1f11, both 1f11 and moab against human platelet glycoprotein (gp) iiia, sz21, could bind to the band of gp iiia of normal platelet lysate, but not ... | 2009 | 19184277 |
| importance of egf receptor, her2/neu and erk1/2 kinase signalling for host cell elongation and scattering induced by the helicobacter pylori caga protein: antagonistic effects of the vacuolating cytotoxin vaca. | helicobacter pylori is the causative agent of gastric pathologies ranging from chronic gastritis to peptic ulcers and even cancer. virulent strains carrying both the cag pathogenicity island (cagpai) and the vacuolating cytotoxin vaca are key players in disease development. the cagpai encodes a type iv secretion system (t4ss) which forms a pilus for injection of the caga protein into gastric epithelial cells. injected caga undergoes tyrosine phosphorylation and induces actin-cytoskeletal rearran ... | 2009 | 19046339 |
| does the expression of cyclin e, prb, and p21 correlate with prognosis in gastric adenocarcinoma? | cyclin e is a protein that plays a key role in the g1 --> s transition of the normal cell cycle. the product of retinoblastoma gene (prb) is the master regulator of entry into the cell cycle and p21 protein is a cyclin-dependent kinase inhibitor that disturbs the progression through the cell cycle. the expression of these proteins, among many others, is being deregulated in tumorogenesis. the aim of this study was to investigate whether cyclin e, prb, and p21 can be used as prognostic indicators ... | 2009 | 19058005 |
| ulcers and gastritis. | 2009 | 19058127 | |
| tight junctions as targets of infectious agents. | the epithelial barrier is a critical border that segregates luminal material from entering tissues. essential components of this epithelial fence are physical intercellular structures termed tight junctions. these junctions use a variety of transmembrane proteins coupled with cytoplasmic adaptors, and the actin cytoskeleton, to attach adjacent cells together thereby forming intercellular seals. breaching of this barrier has profound effects on human health and disease, as barrier deficiencies ha ... | 2009 | 19059200 |
| associations of a ptpn11 g/a polymorphism at intron 3 with helicobactor pylori seropositivity, gastric atrophy and gastric cancer in japanese. | previous studies have revealed the significance of helicobacter pylori (h. pylori) infection as a risk factor of gastric cancer. cytotoxin-associated gene a (caga) positivity has been demonstrated to determine the clinical outcome of h. pylori infection in the presence of shp-2 (src homology 2 domain-containing protein tyrosine phosphatase-2). this study aimed to examine the formerly reported association of g/a ptpn11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) w ... | 2009 | 19589142 |
| lansoprazole, a proton pump inhibitor, suppresses production of tumor necrosis factor-alpha and interleukin-1beta induced by lipopolysaccharide and helicobacter pylori bacterial components in human monocytic cells via inhibition of activation of nuclear factor-kappab and extracellular signal-regulated kinase. | pathogenic bacterial components play critical roles in initiation of gastrointestinal inflammation via activation of intracellular signaling pathways which induce proinflammatory cytokines such as tumor necrosis factor (tnf)-alpha and interleukin (il)-1beta. lansoprazole (lanso), a proton pump inhibitor, has been widely used for the treatment of peptic ulcers and reflux esophagitis due to its potent acid-suppressive effect. it has also been reported to have anti-inflammatory effects. in this stu ... | 2009 | 19590712 |
| influences of cyp2c19 polymorphism on recurrence of reflux esophagitis during proton pump inhibitor maintenance therapy. | patients with erosive gastroesophageal reflux disease (gerd) have rapid recurrence after treatment withdrawal. the aim is to study the influences of cyp2c19 polymorphism on recurrence of gerd during proton pump inhibitor maintenance therapy. | 2009 | 19621685 |
| diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates. | gastric cancer results from a combination of helicobacter pylori (h pylori) infection, exposure to dietary carcinogens, and predisposing genetic make-up. because the role of these factors in gastric carcinogenesis cannot be determined readily in human beings, the present study examined the role of an oral carcinogen and h pylori infection in rhesus monkeys. | 2009 | 19622359 |
| a comparison of glycan expression and adhesion of mouse-adapted strains and clinical isolates of helicobacter pylori. | adherence to the mucosal surface, essential for successful colonization of the gastric mucosa by the human pathogen helicobacter pylori, is predominantly mediated by lectin-like molecules on the helicobacter binding carbohydrates expressed by host epithelial cells. while clinical isolates of h. pylori do not normally infect mice, some strains have been adapted to colonize this host. we hypothesized that adaptation of h. pylori for colonization of mice may involve alterations in either bacterial ... | 2009 | 19624738 |
| helicobacter pylori infection, host genetics and gastric cancer. | helicobacter pylori infects half the world's population and is responsible for a considerable global health burden, including peptic ulcer disease and gastric cancer. the infection causes a chronic gastritis, the severity and distribution of which determine the clinical outcome. bacterial, environmental and host genetic factors combine to define the degree of gastric damage. most patients have a limited mild pan-gastritis with no significant clinical consequences. antral-predominant gastritis is ... | 2009 | 19659782 |
| the bb genotype of heat-shock protein (hsp) 70-2 gene is associated with gastric pre-malignant condition in h. pylori-infected older patients. | heat-shock protein (hsp) 70 plays essential roles in cellular response to a variety of environmental stresses or unfavorable conditions. a to g transition at the 1267 position of the hsp70-2 gene confers different levels of hsp70 mrna expression. we aimed to clarify the effect of hsp70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach. | 2009 | 19661373 |
| role for alpha-l-fucosidase in the control of helicobacter pylori-infected gastric cancer cells. | infecting about one-half of the global human population, helicobacter pylori is well established as the primary cause of gastritis, duodenal ulcer, and gastric cancer. currently there is no clear information regarding if and how host cells interact with h. pylori, and if such interactions are dependent on the type of gastric disease. using fluorescently labeled fucose-containing glycoconjugates, we provide evidence observing both the uptake of l-fucose from gastric cancer cells to h. pylori and ... | 2009 | 19666478 |
| metabolic profiling of helicobacter pylori glycosylation. | metabolic oligosaccharide engineering was used to profile glycoproteins of the human pathogen helicobacter pylori. | 2009 | 19668851 |
| human gastrin: a true growth factor for helicobacter pylori? | 2009 | 19674135 | |
| inhibition of heat shock protein expression by helicobacter pylori. | heat shock proteins (hsps) are primarily known as molecular chaperones that are induced by cell stress and prevent protein aggregation and facilitate folding. recent evidence suggests that exposure of cells to microbial pathogens can also induce hsps, which then modulate both innate and adaptive immune responses. paradoxically, helicobacter pylori has been found to decrease expression of hsps. we sought to investigate this phenomenon further and to examine the role of different h. pylori strains ... | 2009 | 19683049 |
| infectious serologies and autoantibodies in wegener's granulomatosis and other vasculitides: novel associations disclosed using the rad bioplex 2200. | in this study we assess the presence of antibodies against infectious agents as well as for a variety of autoantibodies in an attempt to establish associations between various vasculitides and infections in order to shed light on the etiopathogenesis of these diseases and perhaps implicate a potential cure. sera from patients with wegener's granulomatosis (wg), polyarteritis nodosa, microscopic polyangiitis, churg strauss, and giant cell arteritis were compared to healthy control sera. serum sam ... | 2009 | 19758211 |
| increased expression and cellular localization of lipocalin-type prostaglandin d synthase in helicobacter pylori-induced gastritis. | immunological responses in the host can result in different disease outcomes of helicobacter pylori-induced gastritis. prostaglandin e2 derived from cyclooxygenase (cox) and prostaglandin e synthase contribute to gastric protection. recently, prostaglandin d2 was shown to be involved in host immunity by chemotactic activity through chemoattractant receptor-homologous molecule expressed on th2 cells (crth2), but its role in h. pylori-induced gastritis has not been clarified. we determined the exp ... | 2009 | 19768745 |
| activation of the abundant nuclear factor poly(adp-ribose) polymerase-1 by helicobacter pylori. | modification of eukaryotic proteins is a powerful strategy used by pathogenic bacteria to modulate host cells during infection. previously, we demonstrated that helicobacter pylori modify an unidentified protein within mammalian cell lysates in a manner consistent with the action of a bacterial adp-ribosylating toxin. here, we identified the modified eukaryotic factor as the abundant nuclear factor poly(adp-ribose) polymerase-1 (parp-1), which is important in the pathologies of several disease s ... | 2009 | 19897724 |
| helicobacter urease: niche construction at the single molecule level. | the urease of the human pathogen, helicobacter pylori, is essential for pathogenesis. the ammonia produced by the enzyme neutralizes stomach acid; thereby modifying its environment. the dodecameric enzyme complex has high affinity for its substrate, urea. we compared urease sequences and derivative 3d homology model structures from all published helicobacter genomes and an equal number of genomes belonging to strains of another enteric bacterium, escherichia coli. we found that the enzyme's arch ... | 2009 | 19920336 |
| [study of gene polymorphism responsible for metabolism of proton pump inhibitors in children with h. pylori infection: is there a correlation with efficacy of eradication treatment?]. | the aim of this study was to determine the effects of cyp2c19 polymorphism on h. pylori eradication in pediatric population in the republic of bashkortostan. | 2009 | 19928008 |
| infectious causes of chronic immune thrombocytopenia. | persistent thrombocytopenia may be the consequence of chronic infections with hepatitis c virus (hcv), human immunodeficiency virus (hiv), and helicobacter pylori, and should be considered in the differential diagnosis of primary immune thrombocytopenia (itp). studies have shown that on diagnosis of infections, treatment of the primary disease often results in substantial improvement or complete recovery of the thrombocytopenia. in patients with thrombocytopenia due to hcv-related chronic liver ... | 2009 | 19932434 |
| [association between promoter methylation of cyclooxygenase-2 and expression, and precancerous gastric lesions in a high-risk population]. | to evaluate the relationship between cyclooxygenase-2 (cox-2) methylation and expression, and precancerous gastric lesions. | 2009 | 19954066 |
| [effect of cyp2c19 gene polymorphism on eradication treatment efficacy of helicobacter pylori infection]. | 2009 | 19961004 | |
| clinicopathological characteristics of primary gastric t-cell lymphoma. | to investigate the clinicopathological characteristics of 20 primary gastric t-cell lymphoma (gtcl) cases without human t-lymphotropic virus type i infection in japan, a non-endemic area for coeliac disease. | 2009 | 20002766 |
| host-dependent lewis (le) antigen expression in helicobacter pylori cells recovered from leb-transgenic mice. | variation of surface antigen expression is a mechanism used by microbes to adapt to and persist within their host habitats. helicobacter pylori, a persistent bacterial colonizer of the human stomach, can alter its surface lewis (le) antigen expression. we examined h. pylori colonization in mice to test the hypothesis that host phenotype selects for h. pylori (le) phenotypes. when wild-type and le(b)-expressing transgenic fvb/n mice were challenged with h. pylori strain hp1, expressing le(x) and ... | 2009 | 20008521 |
| a case of hypereosinophilic syndrome presenting with intractable gastric ulcers. | we report a rare case of hypereosinophilic syndrome (hes) presenting with intractable gastric ulcers. a 71-year-old man was admitted with epigastric pain. initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. he underwent helicobacter pylori (h pylori) eradication therapy followed by proton pump inhibitor (ppi) therapy. however, follow-up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. the proporti ... | 2009 | 20027690 |