Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| hereditary fleck dystrophy associated with decreased corneal sensitivity. | 2015 | 4537353 | |
| [treatment of diseases of permanent teeth with unformed roots. 2. treatment of diseases of the pulp]. | 2015 | 4508803 | |
| [activity of leucocyte alkaline phosphatase in girls aged 7-15 years]. | 2015 | 4641007 | |
| [2 misleading forms of acute perforated appendicitis in young infants: association with acute intestinal invagination: presentation simulating an acute orchitis syndrome]. | 2015 | 4543651 | |
| [prognosis in leprosy]. | 2015 | 4480378 | |
| [radioimmunological determination of parathormone in chronic renal failure]. | 2015 | 4820156 | |
| "and then there were none". | 2015 | 4485126 | |
| [experimental study on postexodontic wound healing with special reference to the use of dental cones of a combination of neomyson and lysozyme]. | 2015 | 4549827 | |
| 2,3-diphosphoglycerate concentrations and the dissociation of oxyhaemoglobin in ventilatory failure. | 2015 | 4448040 | |
| association between hypokaliaemic alkalosis and development of arrhythmia in early postoperative period. | 2015 | 4447254 | |
| [immunoglobulins in the cervico-vaginal content of clinically normal women and of women with trichomonas, candida or bacterial infections]. | 2015 | 4425180 | |
| development of temporomandibular joint innervation. | 2015 | 4529279 | |
| the toxicity of 2,3,7,8-tetrachlorodilbenzo-p-dioxin (tcdd) in guppies (poecilia reticulatus peters). | 2015 | 4433855 | |
| a transplantable pregnancy-dependent mammary tumor line (tpdmt-4) in strain ddd mice. | 2015 | 4426477 | |
| [drug permeation through synthetic lipid membranes. permeability of lecithin-collodium membranes for drugs and metabolites]. | 2015 | 4420510 | |
| proceedings: effect of synthetic corticotrophin analogues on plasma delta4-androstenedione, testosterone and gonadotrophins in normal men. | 2015 | 4364188 | |
| an internal auditing system for improving the quality of medical care. | 2015 | 4363405 | |
| [therapy of bronchial asthma]. | 2015 | 4372025 | |
| [reflection of the establishment of soviet public health in the graphic arts]. | 2015 | 4885213 | |
| prolongation of a pancuronium-induced neuronmuscular blockade by polymyxin b. | 2015 | 4359101 | |
| characterization of soluble, fsf-stabilized fibrin complexes with special reference to the role of fibrinogen. | 2015 | 4428469 | |
| in memoriam arthur kallet. | 2015 | 4551865 | |
| [selectivity of action of propericiazine in behavior disorders]. | 2015 | 4384082 | |
| stereochemical aspects of antihistamine action. 4. absolute configuration of carbinoxamine antipodes. | 2015 | 4400865 | |
| [urgency in the repair of retinal detachment (author's transl)]. | 2015 | 4437016 | |
| [inter-individual differences in pharmacokinetics in humans: clinical importance]. | 2015 | 4703858 | |
| the spleen in chronic renal failure and renal transplantation. | 2015 | 4619670 | |
| treating incontinence electrically. | 2015 | 4537748 | |
| [abortion experiment in the polyclinic]. | 2015 | 4482385 | |
| clinical studies with naloxone/methadone in a ratio of 1:20. | 2015 | 4612372 | |
| genetic activity of sex chromosomes in somatic cells of mammals. | 2015 | 4399067 | |
| participation of monocytes in transient glomerular hypercellularity in poststreptococcal glomerulonephritis. | 2015 | 4350411 | |
| nursing education: "the clarnnda plan". | 2015 | 4322725 | |
| [cerebral circulatory insufficiency in aged persons]. | 2015 | 4656193 | |
| raymond sabouraud (1864-1938) french dermatologist. | 2015 | 4918246 | |
| sickle cell disease and transitional cell carcinoma of the renal pelvis: a case report. | 2015 | 4695088 | |
| letter: the "territorial domain" of hemoptysis. | 2015 | 4832279 | |
| letter: the "territorial domain" of hemoptysis. | 2015 | 4832279 | |
| association of nonhomologous chromosomes in drosophila virilis at different stages of development. | 2015 | 4428218 | |
| 'metabolic' neuropathies and myopathies in infancy and childhood. | 2015 | 4398416 | |
| letter: re: senate bills s. 3588 (1972) and s2724 (1973) to establish a federal radiation protection agency. | 2015 | 4436070 | |
| interest sags on issue of national health care. | 2015 | 4500777 | |
| [prinzmetal's angina. coronarographic picture and surgical therapy]. | 2015 | 4539522 | |
| [bone changes in diabetics]. | 2015 | 4453288 | |
| dark recovery of erp in isolated octopus retina. | 2015 | 4648395 | |
| biochemically active substances from actinomycetes and other organisms. ii. effects of various compounds on motilometry. | 2015 | 4366190 | |
| acedapsone in leprosy treatment: trial in 68 active cases in micronesia. | 2015 | 4672994 | |
| [etiology of limitation of the opening of the mouth]. | 2015 | 4510155 | |
| [rational impression technic for precise clasp and fixed dentures. ii]. | 2015 | 4596554 | |
| distance diagnosis of acute peritonitis by means of electronic computers. | 2015 | 4551927 | |
| plasma lipoproteins and hyperlipoproteinemia. | 2015 | 4352670 | |
| [early changes in thoracic radiographs following surgical operations of the thorax]. | 2015 | 4569734 | |
| treatment of viral hepatitis. | 2015 | 4469895 | |
| a hospital riot: its determinants and implications for treatment. | 2015 | 4701950 | |
| a hospital riot: its determinants and implications for treatment. | 2015 | 4701950 | |
| a study of services and needs of teenage pregnant girls in the large cities of the united states. | 2015 | 4682630 | |
| diet and coronary heart disease: developments in 1973. | 2015 | 4527750 | |
| cancer of the gastrointestinal tract. cytology in early diagnosis. | 2015 | 4595673 | |
| editorial: topics in radiology. | 2015 | 4406740 | |
| [must one reveal to the patient his proximate death?]. | 2015 | 4313913 | |
| [mandibular resections. 6. mandibular resections followed by prosthesis]. | 2015 | 4642564 | |
| travel-related shigellosis in quebec, canada: an analysis of risk factors. | travel-related shigellosis is not well documented in canada although it is frequently acquired abroad and can cause severe disease. | 2015 | 24889090 |
| hypoxic stress, hepatocytes and caco-2 viability and susceptibility to shigella flexneri invasion. | inflammation due to shigella flexneri can cause damage to the colonic mucosa and cell death by necrosis and apoptosis. this bacteria can reach the bloodstream in this way, and the liver through portal veins. hypoxia is a condition present in many human diseases, and it may induce bacterial translocation from intestinal lumen. we studied the ability of s. flexneri to invade rat hepatocytes and caco-2 cells both in normoxic and hypoxic microenvironments, as well as morphological and physiological ... | 2015 | 24037289 |
| detection and analysis of crisprs of shigella. | the recently discovered crisprs (clustered regularly interspaced short palindromic repeats) and cas (crispr-associated) proteins are a novel genetic barrier that limits horizontal gene transfer in prokaryotes and the crispr loci provide a historical view of the exposure of prokaryotes to a variety of foreign genetic elements. the aim of study was to investigate the occurrence and distribution of the crisprs in shigella. a collection of 61 strains of shigella were screened for the existence of cr ... | 2015 | 25199561 |
| transcriptional adaptation of shigella flexneri during adherence to epithelial cells. | shigella adhesion to host cells is a transitional stage from an extracellular to an intracellular environment. however, the dynamic adaptations of shigella during adhesion are poorly understood. to address this, we performed the first transcriptome analysis of shigella flexneri 2457t during adhesion. a total of 1,757 genes were differentially regulated (>twofold). the majority of plasmid-borne ipa-mxi-spa locus genes were downregulated, indicating these virulence genes were strictly regulated af ... | 2015 | 25291620 |
| update on molecular epidemiology of shigella infection. | shigella spp. are important etiologic agents of diarrhea worldwide. this review summarizes the recent findings on the epidemiology, diagnosis, virulence genes, and pathobiology of shigella infection. | 2015 | 25394237 |
| outbreak of locally acquired azithromycin-resistant shigella flexneri infection in men who have sex with men. | 2015 | 25474524 | |
| the shigella flexneri ospb effector: an early immunomodulator. | through the action of the type three secretion system (t3ss) shigella flexneri delivers several effectors into host cells to promote cellular invasion, multiplication and to exploit host-cell signaling pathways to modulate the host innate immune response. although much progress has been made in the understanding of many type iii effectors, the molecular and cellular mechanism of the ospb effector is still poorly characterized. in this study we present new evidence that better elucidates the role ... | 2015 | 25434600 |
| mutational analysis of the major periplasmic loops of shigella flexneri wzy: identification of the residues affecting o antigen modal chain length control, and wzz-dependent polymerization activity. | the o antigen (oag) component of lps is a major shigella flexneri virulence determinant. oag is polymerized by wzysf, and its modal chain length is determined by wzzsf and wzzphs2. site-directed mutagenesis was performed on wzysf in pwaldo-wzysf-tev-gfp to alter arg residues in wzysf's two large periplasmic loops (pls) (pl3 and pl5). analysis of the lps profiles conferred by mutated wzysf proteins in the wzysf deficient (δwzy) strain identified residues that affect wzysf activity. the importance ... | 2015 | 25627441 |
| specific 13c labeling of leucine, valine and isoleucine methyl groups for unambiguous detection of long-range restraints in protein solid-state nmr studies. | here we present an isotopic labeling strategy to easily obtain unambiguous long-range distance restraints in protein solid-state nmr studies. the method is based on the inclusion of two biosynthetic precursors in the bacterial growth medium, α-ketoisovalerate and α-ketobutyrate, leading to the production of leucine, valine and isoleucine residues that are exclusively (13)c labeled on methyl groups. the resulting spectral simplification facilitates the collection of distance restraints, the verif ... | 2015 | 25625825 |
| genetic characterization of shigella flexneri isolates in guizhou province, china. | shigella flexneri is one of the major etiologic causes of shigellosis in guizhou province, china. however, the genetic characteristics of circulating isolates are unknown. phenotypic and molecular profiles of 60 s. flexneri isolates recovered in guizhou between 1972 to 1982 and 2008 to 2010 were determined. nine serotypes (1a, 2a, 3a, 1b, 2b, x, y, 4av and yv) were identified. multi-locus sequence typing differentiated the isolates into 20 sequence types (sts); 18 were novel. four sts, st 129, s ... | 2015 | 25617838 |
| overexpression, purification, crystallization and preliminary x-ray crystallographic analysis of sf173 from shigella flexneri. | shigella flexneri is a gram-negative, anaerobic bacterium in the genus shigella that can cause diarrhoea in humans. sf173, a hypothetical protein from s. flexneri 5a strain m90t, has been cloned, overexpressed, purified and crystallized as a part of laboratory-scale structural genomics project. the sf173 protein was crystallized using the sitting-drop vapour-diffusion method in the presence of 0.8 m succinic acid ph 7.0 at 293 k. preliminary x-ray diffraction analysis revealed that the crystal d ... | 2015 | 25615969 |
| tom1 is a pi5p effector involved in the regulation of endosomal maturation. | phosphoinositides represent a major class of lipids specifically involved in the organization of signaling cascades, maintenance of the identity of organelles and regulation of multiple intracellular trafficking steps. we previously reported that phosphatidylinositol 5-monophosphate (pi5p), produced by the shigella flexneri phosphatase ipgd, is implicated in the endosomal sorting of the epidermal growth factor receptor (egfr). here, we show that the adaptor protein tom1 is a new direct binding p ... | 2015 | 25588840 |
| comparison of resistance to third-generation cephalosporins in shigella between europe-america and asia-africa from 1998 to 2012. | we conducted a systematic review to compare resistance to third-generation cephalosporins (tgcs) in shigella strains between europe-america and asia-africa from 1998 to 2012 based on a literature search of computerized databases. in asia-africa, the prevalence of resistance of total and different subtypes to ceftriaxone, cefotaxime and ceftazidime increased markedly, with a total prevalence of resistance up to 14·2% [95% confidence interval (ci) 3·9-29·4], 22·6% (95% ci 4·8-48·6) and 6·2% (95% c ... | 2015 | 25553947 |
| myristoylome profiling reveals a concerted mechanism of arf gtpase deacylation by the bacterial protease ipaj. | n-myristoylation is an essential fatty acid modification that governs the localization and activity of cell signaling enzymes, architectural proteins, and immune regulatory factors. despite its importance in health and disease, there are currently no methods for reversing protein myristoylation in vivo. recently, the shigella flexneri protease ipaj was found to cleave myristoylated glycine of eukaryotic proteins, yet the discriminatory mechanisms of substrate selection required for targeted demy ... | 2015 | 25773595 |
| shigella flexneri regulation of arf6 activation during bacterial entry via an ipgd-mediated positive feedback loop. | entry into cells is critical for virulence of the human bacterial pathogens shigella spp. shigella spp. induce membrane ruffle formation and macropinocytic uptake, but the events instigating this process are incompletely understood. the host small gtpase adp-ribosylation factor 6 (arf6) functions in membrane trafficking at the plasma membrane and activates membrane ruffle formation. we demonstrate that arf6 is required for efficient shigella flexneri entry, is activated by s. flexneri dependent ... | 2015 | 25736891 |
| aa479 antiserum: new reagent for the serotype characterization of atypical variants of shigella flexneri. | shigella flexneri is divided into 13 serotypes based on the combination of antigenic determinants present in the o-antigen. a new o-antigen modification with phosphoethanolamine has been identified. the presence of this antigenic determinant (called e1037) is recognized by monoclonal antibody masf iv-1. given the increasing incidence of these new variants and the difficulty in supplying the monoclonal antibody to our country, we produced a polyclonal antiserum (aa479) through immunization with a ... | 2015 | 25735215 |
| shift in serotype distribution of shigella species in china, 2003-2013. | we identified 2912 shigella isolates from diarrhoeal patients in china during 2003-2013. the most common species was shigella flexneri (55.3%), followed by shigella sonnei (44.1%); however, s. sonnei is becoming increasingly prevalent. among the s. flexneri isolates, serotypes 2a and x variant (-:7,8, e1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. overall, s. sonnei, s. flexneri 2a and s. flexneri x variant (-:7,8, e1037) accounte ... | 2015 | 25658535 |
| shigella flexneri serotype 1 infections in men who have sex with men in vancouver, canada. | outbreaks of shigellosis have been documented in men who have sex with men (msm), associated with interpersonal transmission and underlying hiv infection. we observed a rise in shigella flexneri isolates identified in a downtown tertiary-care hospital laboratory located within the city centre community health area (cha-1) of vancouver, canada. the objectives of this study were to evaluate clinical outcomes of shigellosis cases among msm admitted to hospital and to evaluate trends in shigella cas ... | 2015 | 25656740 |
| the passenger-associated transport repeat promotes virulence factor secretion efficiency and delineates a distinct autotransporter subtype. | autotransporters are a superfamily of virulence factors secreted by gram negative bacteria. they are comprised of an n-terminal passenger domain that is translocated across the outer membrane and a c-terminal domain that inserts into the outer membrane forming a β-barrel anchor. it is still poorly understood how the passenger is efficiently translocated in the absence of external energy inputs. several mechanisms have been proposed in solution of this problem, yet due to the vast diversity of si ... | 2015 | 25869731 |
| enhanced resistance to fluoroquinolones in laboratory-grown mutants & clinical isolates of shigella due to synergism between efflux pump expression & mutations in quinolone resistance determining region. | there is a worldwide emergence of fluoroquinolone resistance in shigella species. to understand the molecular mechanisms associated with fluoroquinolone resistance, naturally occurring fluoroquinolone-resistant strains and laboratory-induced spontaneous mutants of shigella spp. were used and the relative contributions of acrab-tolc efflux pumps, gyrase and topoisomerase target gene mutations towards fluoroquinolone resistance were determined. | 2015 | 25857499 |
| myosin-x and disease. | myosin-x (myo10) is a motor protein best known for its role in filopodia formation. new research implicates myo10 in a number of disease states including cancer metastasis and pathogen infection. this review focuses on these developments with emphasis on the emerging roles of myo10 in formation of cancer cell protrusions and metastasis. a number of aggressive cancers show high levels of myo10 expression and knockdown of myo10 has been shown to dramatically limit cancer cell motility in 2d and 3d ... | 2015 | 25819274 |
| key residues of s. flexneri ompa mediate infection by bacteriophage sf6. | many viruses, including bacteriophage, have the inherent ability to utilize several types of proteinaceous receptors as an attachment mechanism to infect cells, yet the molecular mechanisms that drive receptor binding have not been elucidated. using bacteriophage sf6 and its host, shigella flexneri, we investigated how sf6 utilizes outer membrane protein a (ompa) for infection. specifically, we identified that surface loops of ompa mediate shigella infection. we further characterized which resid ... | 2015 | 25816773 |
| o-antigen modifications providing antigenic diversity of shigella flexneri and underlying genetic mechanisms. | o-antigens (o-specific polysaccharides) of shigella flexneri, a primary cause of shigellosis, are distinguished by a wide diversity of chemical modifications following the oligosaccharide o-unit assembly. the present review is devoted to structural, serological, and genetic aspects of these modifications, including o-acetylation and phosphorylation with phosphoethanolamine that have been identified recently. the modifications confer the host with specific immunodeterminants (o-factors or o-antig ... | 2015 | 26542003 |
| [analysis of the drug resistance and the integron resistance gene cassette's characteristics of shigella flexneri]. | to investigate the correlation between shigella flexneri multi-drug resistance and drug resistance gene cassette of integrons. | 2015 | 26758113 |
| comparative proteomics of shigella flexneri 2a strain 301 using a rabbit ileal loop model reveals key proteins for bacterial adaptation in host niches. | many studies focusing on changes in the host following shigella spp invasion have been reported in recent years. however, the key factors required for the adaptation of these pathogens to host niches have usually been neglected. | 2015 | 26417879 |
| identification of shigella flexneri isolates carrying the shiga toxin 1-producing gene in quebec, canada, linked to travel to haiti. | 2015 | 26401981 | |
| vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of shigella flexneri at the cell periphery. | shigella spp. are intracellular bacterial pathogens that cause diarrhoeal disease in humans. shigella utilize the host actin cytoskeleton to enter cells, move through the cytoplasm of cells and pass into adjacent cells. ena/vasp family proteins are highly conserved proteins that participate in actin-dependent dynamic cellular processes. we tested whether ena/vasp family members vasp (vasodilator-stimulated phosphoprotein), mena (mammalian-enabled) or evl (ena-vasp-like) contribute to shigella fl ... | 2015 | 26358985 |
| shigellosis outbreak in al batinah south governorate, oman: case-control study. | an outbreak of acute gastroenteritis due to shigella flexneri occurred in august 2012 in the catchment area of the wadi sahtan health center in rustaq, al batinah south governorate, oman. the aim of this study was to discover possible causes of this outbreak in the villages of fassa, rogh and amk and to measure the risk of exposure among cases and controls. | 2015 | 26357558 |
| mechanism of action and initial, in vitro sar of an inhibitor of the shigella flexneri virulence regulator virf. | shigella spp. are among the main causative agents of acute diarrheal illness and claim more than 1 million lives per year worldwide. there are multiple bacterial genes that control the pathogenesis of shigella, but the virf gene may be the most important. this gene, located on the primary pathogenicity island of shigella, encodes virf, an arac-family transcriptional activator that is responsible for initiating the pathogenesis cycle in shigella. we have previously shown that it is possible to at ... | 2015 | 26352269 |
| investigation on the synthesis of shigella flexneri specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates. | chemo-enzymatic strategies hold great potential for the development of stereo- and regioselective syntheses of structurally defined bioactive oligosaccharides. herein, we illustrate the potential of the appropriate combination of a planned chemo-enzymatic pathway and an engineered biocatalyst for the multistep synthesis of an important decasaccharide for vaccine development. we report the stepwise investigation, which led to an efficient chemical conversion of allyl α-d-glucopyranosyl-(1→4)-α-l- ... | 2015 | 26340432 |
| a small conserved motif supports polarity augmentation of shigella flexneri icsa. | the rod-shaped enteric intracellular pathogen shigella flexneri and other shigella species are the causative agents of bacillary dysentery. s. flexneri are able to spread within the epithelial lining of the gut, resulting in lesion formation, cramps and bloody stools. the outer membrane protein icsa is essential for this spreading process. icsa is the initiator of an actin-based form of motility whereby it allows the formation of a filamentous actin 'tail' at the bacterial pole. importantly, ics ... | 2015 | 26315462 |
| determinants of proteolysis and cell-binding for the shigella flexneri cytotoxin, siga. | shigella flexneri secretes an enterotoxic, spate family autotransporter (at), siga, which has cytopathic activity towards cultured epithelial cells. its cytopathic activity is due to its ability to degrade the cytoskeletal protein, α-fodrin. the mechanisms by which at toxins target cells and tissues differ and the details of how siga acts are not known. in the current study, the determinants of proteolysis and cell-targeting for siga were determined. we demonstrate that the siga passenger or α-d ... | 2015 | 26297175 |
| detection of wzy/wzz interaction in shigella flexneri. | the o antigen (oag) component of shigella flexneri lipopolysaccharide (lps) is important for virulence and a protective antigen. it is synthesized by the wzy-dependent mechanism. s. flexneri wzy has 12 transmembrane segments and two large periplasmic loops. the modal chain length of the oag is determined by wzz. experimental evidence supports multi-protein interactions in the wzy-dependent pathway. however, evidence for direct interaction of wzy with the other proteins of the wzy-dependent pathw ... | 2015 | 26296569 |
| quantification of cytosolic vs. vacuolar salmonella in primary macrophages by differential permeabilization. | intracellular bacterial pathogens can replicate in the cytosol or in specialized pathogen-containing vacuoles (pcvs). to reach the cytosol, bacteria like shigella flexneri and francisella novicida need to induce the rupture of the phagosome. in contrast, salmonella typhimurium replicates in a vacuolar compartment, known as salmonella-containing vacuole (scv). however certain mutants of salmonella fail to maintain scv integrity and are thus released into the cytosol. the percentage of cytosolic v ... | 2015 | 26274778 |
| sting signaling the energic way. | the effector proteins ipaj and vira, from the bacterium shigella flexneri, block the general secretory pathway (gsp) at different stages. in this issue of cell host & microbe, dobbs et al. (2015) use these proteins as a tool to pinpoint sting trafficking and signaling to the er-golgi intermediate compartment (ergic). | 2015 | 26269948 |
| mutations in gyra & parc genes of shigella flexneri 2a determining the fluoroquinolone resistance. | 2015 | 26205028 | |
| bacterial internalization, localization, and effectors shape the epithelial immune response during shigella flexneri infection. | intracellular pathogens are differentially sensed by the compartmentalized host immune system. nevertheless, gene expression studies of infected cells commonly average the immune responses, neglecting the precise pathogen localization. to overcome this limitation, we dissected the transcriptional immune response to shigella flexneri across different infection stages in bulk and single cells. this identified six distinct transcriptional profiles characterizing the dynamic, multilayered host respo ... | 2015 | 26123804 |
| hfq regulates acid tolerance and virulence by responding to acid stress in shigella flexneri. | shigella flexneri is an important etiological agent of bacillary dysentery in developing countries. the hfq protein is thought to play a major regulatory role in various cellular processes in this organism. however, the roles of hfq in stress tolerance and virulence in s. flexneri in response to environmental stress have not been fully studied. in this study, hfq was highly expressed when s. flexneri was exposed to low ph. growth retardation was observed in the hfq deletion mutant at ph values r ... | 2015 | 26117597 |
| clonal dissemination of a single shigella sonnei strain among iranian children during fall 2012 in tehran, i.r. iran. | shigella species are a common cause of bacterial diarrhea worldwide and the disease is characterized by seasonality. shigella has been encountered by widespread resistance to commonly used antibiotics which is a serious concern. the aim of this study was to analyze the epidemiological relatedness of shigella strains isolated from children during one year period by pfge method and to investigate antimicrobial resistance determinants and cassettes among shigella species. the occurrence of shigella ... | 2015 | 26117443 |