Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| continuous positive airway pressure with helmet versus mask in infants with bronchiolitis: an rct. | noninvasive continuous positive airway pressure (cpap) is usually applied with a nasal or facial mask to treat mild acute respiratory failure (arf) in infants. a pediatric helmet has now been introduced in clinical practice to deliver cpap. this study compared treatment failure rates during cpap delivered by helmet or facial mask in infants with respiratory syncytial virus-induced arf. | 2015 | 25780074 |
| leukotriene inhibitors for bronchiolitis in infants and young children. | bronchiolitis is an acute inflammatory illness of the bronchioles common among infants and young children. it is often caused by the respiratory syncytial virus (rsv). management of bronchiolitis varies between clinicians, reflecting the lack of evidence for a specific treatment approach. the leukotriene pathway has been reported to be involved in the pathogenesis of bronchiolitis. leukotriene inhibitors such as montelukast have been used in infants and young children with bronchiolitis. however ... | 2015 | 25773054 |
| rsv vaccine-enhanced disease is orchestrated by the combined actions of distinct cd4 t cell subsets. | there is no currently licensed vaccine for respiratory syncytial virus (rsv) despite being the leading cause of lower respiratory tract infections in children. children previously immunized with a formalin-inactivated rsv (fi-rsv) vaccine exhibited enhanced respiratory disease following natural rsv infection. subsequent studies in animal models have implicated roles for cd4 t cells, eosinophils and non-neutralizing antibodies in mediating enhanced respiratory disease. however, the underlying imm ... | 2015 | 25769044 |
| safety and pharmacokinetics of extended use of palivizumab in saudi arabian infants and children. | the peak season of respiratory syncytial virus (rsv) infections in warmer climates may extend beyond the typical five-month rsv season of temperate regions. additional monthly doses of palivizumab may be necessary in warmer regions to protect children at high risk for serious infection by the rsv. | 2015 | 25767550 |
| head-to-head comparison of the diagnostic accuracies of bd veritor™ system rsv and quidel® sofia® rsv fia systems for respiratory syncytial virus (rsv) diagnosis. | respiratory syncytial virus (rsv) is one of the most common causes of severe lower respiratory tract disease among infants and young children. bd veritor™ system rsv (bd) and quidel(®) sofia(®) rsv fia (qd) are the new generation lateral flow digital immunoassay (dia) tests with an instrumented read for the qualitative detection of rsv viral antigens. | 2015 | 25766995 |
| molecular characterization of respiratory syncytial viruses infecting children reported to have received palivizumab immunoprophylaxis. | respiratory syncytial virus (rsv) is a major cause of respiratory infections in children. palivizumab (pz) is the only rsv-specific immunoprophylaxis approved by the u.s. food and drug administration. mutations leading to amino acid substitutions in the pz binding site of the rsv f protein have been associated with breakthrough rsv infections in patients receiving pz. | 2015 | 25766983 |
| [acute conjunctivitis caused by respiratory syncytial virus a group]. | 2015 | 25764947 | |
| history of passive antibody administration for prevention and treatment of infectious diseases. | we describe the history of passive immunization to provide context for the series of articles to follow. the history of passive immunization with antibodies to prevent or treat infectious diseases is a story of different eras. there was an extraordinary era of discovery and clinical implementation before the chemical nature of antibodies was even known. this empirical process provided the resources and reagents used to describe and characterize humoral immunity, better define the chemical proper ... | 2015 | 25760933 |
| oral ribavirin for respiratory syncytial virus infection after lung transplantation: efficacy and cost-efficiency. | respiratory syncytial virus (rsv) causes serious respiratory tract infections in lung transplant (ltx) recipients, is associated with development of bronchiolitis obliterans syndrome, and has no proven effective therapy. we evaluated the efficacy, safety, and cost-effectiveness of oral ribavirin for the treatment of rsv infection after ltx. | 2015 | 25753833 |
| palivizumab epitope-displaying virus-like particles protect rodents from rsv challenge. | respiratory syncytial virus (rsv) is the most common cause of serious viral bronchiolitis in infants, young children, and the elderly. currently, there is not an fda-approved vaccine available for rsv, though the mab palivizumab is licensed to reduce the incidence of rsv disease in premature or at-risk infants. the palivizumab epitope is a well-characterized, approximately 24-aa helix-loop-helix structure on the rsv fusion (f) protein (f254-277). here, we genetically inserted this epitope and mu ... | 2015 | 25751145 |
| intensive care unit admission rates for respiratory syncytial virus infection as a function of age in preterm infants born at 32-35-week gestation and not receiving immunoprophylaxis. | 2015 | 25742086 | |
| cesarean section and hospitalization for respiratory syncytial virus infection. | 2015 | 25741978 | |
| effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines. | in several reports, the respiratory syncytial virus (rsv) was identified as an oncolytic virus in cancer cells (e.g., lung and prostate cancer). however, the effects of rsv in hepatocellular carcinoma (hcc) cells have not yet been investigated. here, we observed the inhibitory effects of rsv infection in hcc cell-lines. cell growth was significantly decreased by rsv infection in bnl-hcc, hep3b, huh-7 and snu-739 cells. after rsv infection, plaque formation and syncytial formation were observed i ... | 2015 | 25739391 |
| impaired antibody-mediated protection and defective iga b-cell memory in experimental infection of adults with respiratory syncytial virus. | despite relative antigenic stability, respiratory syncytial virus (rsv) reinfects throughout life. after more than 40 years of research, no effective human vaccine exists and correlates of protection remain poorly defined. most current vaccine candidates seek to induce high levels of rsv-specific serum neutralizing antibodies, which are associated with reduced rsv-related hospitalization rates in observational studies but may not actually prevent infection. | 2015 | 25730467 |
| quantifying maternally derived respiratory syncytial virus specific neutralising antibodies in a birth cohort from coastal kenya. | severe respiratory syncytial virus (rsv) disease occurs predominantly in children under 6 months of age. there is no licensed rsv vaccine. protection of young infants could be achieved by a maternal vaccine to boost titres of passively transferred protective antibodies. data on the level and kinetics of functional rsv-specific antibody at birth and over the early infant period would inform vaccine product design. | 2015 | 25725445 |
| il-33 receptor (st2) signalling is important for regulation of th2-mediated airway inflammation in a murine model of acute respiratory syncytial virus infection. | t1/st2, an orphan receptor with homology with the interleukin (il)-1 receptor family, is the ligand-binding component of the receptor for the cytokine il-33, a newly identified cytokine known to amplify the th2 cell-dominant immune responses. the function of il-33/st2 signalling during respiratory syncytial virus (rsv) infection is not fully known. in this study, following intranasal infection with rsv, balb/c mice showed a marked increase in the production of il-33, with an elevated expression ... | 2015 | 25721734 |
| understanding the association of human rhinovirus with asthma. | human rhinoviruses are ubiquitous seasonal pathogens. they have known associations with first onset of wheezing illnesses in children and with asthma exacerbations in patients of all ages. it is not yet certain whether human rhinoviruses play a direct role in the pathogenesis of asthma by activating deleterious inflammatory responses or if they only serve as a catalyst to accelerate the disease in genetically predisposed individuals. there have been previously demonstrated reductions in the deve ... | 2015 | 26376925 |
| clinical and laboratory characteristics of viral lower respiratory tract infections in preschool children. | viral lower respiratory tract infections are the leading cause of hospitalizations in preschool children. clinical pictures of different viral causes are not well characterized. the aim of this study was to establish the differences in clinical and laboratory characteristics between the different viral causes of lower respiratory tract infections in preschool children. | 2015 | 26373742 |
| antibodies enhance cxcl10 production during rsv infection of infant and adult immune cells. | respiratory syncytial virus (rsv) bronchiolitis is a major burden in infants below three months of age, when the primary immune response is mainly dependent on innate immunity and maternal antibodies. we investigated the influence of antibodies on innate immunity during rsv infection. pbmcs from infants and adults were stimulated with live rsv and inactivated rsv in combination with antibody-containing and antibody-depleted serum. the immune response was determined by transcriptome analysis and ... | 2015 | 26253531 |
| alcohol during pregnancy worsens acute respiratory infections in children. | this study explored whether alcohol consumption during pregnancy increased the risk of life-threatening respiratory infections in children. | 2015 | 26249835 |
| the changing landscape of respiratory syncytial virus. | recognition of the acute and chronic burden of respiratory syncytial virus (rsv) lower respiratory tract infections (lrti) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. rsv is a leading cause of hospitalization in infants in industrialized and developing countries, has been causally linked to recurrent wheezing during childhood, associated with pediatric asthma, and is an important cause of mortality in the first months of life ... | 2015 | 26247900 |
| serious adverse events in the canadian registry of children receiving palivizumab (caress) for respiratory syncytial virus prevention. | to evaluate the safety and tolerability of palivizumab for rsv prophylaxis in high-risk children in everyday practice. | 2015 | 26237402 |
| epidemiological features of bronchiolitis in the pediatric clinic of clinical center of sarajevo university. | to present the epidemiological features of bronchiolitis in a one-year period in patients of pediatric clinic, clinical centre of sarajevo university. | 2015 | 26236159 |
| a metabolomics approach to studying the effects of jinxin oral liquid on rsv-infected mice using uplc/ltq-orbitrap mass spectrometry. | jinxin oral liquid (jol) is a traditional chinese medicine (tcm) formula modified from ma-xing-shi-gan-tang, an ancient formula widely used in the treatment of respiratory diseases such as bronchitis, pneumonia, and asthma. in our previous studies, jol was shown to safely and effectively treat viral pneumonia, especially that involving respiratory syncytial virus (rsv). | 2015 | 26234176 |
| association of respiratory picornaviruses with high acuity and severe illness in a pediatric health care system. | we aimed to determine the illness severity associated with respiratory picornaviruses (rhinovirus/enterovirus). | 2015 | 26231633 |
| morphogenesis of respiratory syncytial virus in human primary nasal ciliated epithelial cells occurs at surface membrane microdomains that are distinct from cilia. | the distribution of cilia and the respiratory syncytial virus (rsv) nucleocapsid (n) protein, fusion (f) protein, attachment (g) protein, and m2-1 protein in human ciliated nasal epithelial cells was examined at between 1 and 5 days post-infection (dpi). all virus structural proteins were localized at cell surface projections that were distinct from cilia. the f protein was also trafficked into the cilia, and while its presence increased as the infection proceeded, the n protein was not detected ... | 2015 | 26231613 |
| building a better neonatal mouse model to understand infant respiratory syncytial virus disease. | respiratory syncytial virus (rsv) is the number one cause of lower respiratory tract infection in infants; and severe rsv infection in infants is associated with asthma development. today, there are still no vaccines or specific antiviral therapies against rsv. the mechanisms of rsv pathogenesis in infants remain elusive. this is partly due to the fact that the largely-used mouse model is semi-permissive for rsv. the present study sought to determine if a better neonatal mouse model of rsv infec ... | 2015 | 26231396 |
| hubs to spread technology and save lives. | the patent on an expensive preventive treatment for respiratory syncytial virus infections expires this year. a who technology transfer hub in the netherlands aims to help developing countries make the drug themselves. gary humphreys reports. | 2015 | 26229198 |
| respiratory syncytial virus infection inhibits tlr4 signaling via up-regulation of mir-26b. | respiratory syncytial virus (rsv) is the leading cause of lower respiratory tract illnesses in infants worldwide. tlr4 signal pathway plays a critical role in regulating immune response against rsv infection. however, the activation of tlr4 in rsv infection is still unclear. in present study, the expression levels of mir-26b and tlr4 mrna were detected in peripheral blood mononuclear cells (pbmcs) of children with or without rsv infected bronchiolitis. the expression levels of tlr4 and its downs ... | 2015 | 26222045 |
| does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis? | 2015 | 26215052 | |
| enhanced immunogenicity of a respiratory syncytial virus (rsv) f subunit vaccine formulated with the adjuvant gla-se in cynomolgus macaques. | respiratory syncytial virus (rsv) causes significant disease in elderly adults, but an effective vaccine is not yet available. we have previously reported that vaccines consisting of engineered respiratory syncytial virus soluble fusion protein (rsv sf) adjuvanted with glucopyranosyl lipid a (gla) in an oil-in-water emulsion (stable emulsion [se]) induce rsv f-specific t and b cell responses in mice and rats that protect from viral challenge. here, we evaluated the immunogenicity of gla-se adjuv ... | 2015 | 26206269 |
| respiratory syncytial virus-like nanoparticle vaccination induces long-term protection without pulmonary disease by modulating cytokines and t-cells partially through alveolar macrophages. | the mechanisms of protection against respiratory syncytial virus (rsv) are poorly understood. virus-like nanoparticles expressing rsv glycoproteins (eg, a combination of fusion and glycoprotein virus-like nanoparticles [fg vlps]) have been suggested to be a promising rsv vaccine candidate. to understand the roles of alveolar macrophages (ams) in inducing long-term protection, mice that were 12 months earlier vaccinated with formalin-inactivated rsv (fi-rsv) or fg vlps were treated with clodronat ... | 2015 | 26203246 |
| [detection of respiratory syncytial virus in the conjunctiva of a child with bronchiolitis caused by this virus]. | 2015 | 26200035 | |
| innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection. | respiratory syncytial virus (rsv) is the major leading cause of infantile viral bronchiolitis. however, cellular phenotypes contributing to the rsv protection and vaccine-enhanced disease remain largely unknown. upon rsv challenge, we analyzed phenotypes and cellularity in the lung of mice that were naïve, immunized with formalin inactivated rsv (fi-rsv), or re-infected with rsv. in comparison with naïve and live rsv re-infected mice, the high levels of eosinophils, neutrophils, plasmacytoid and ... | 2015 | 26196232 |
| healthy late-preterm infants born 33-36+6 weeks gestational age have higher risk for respiratory syncytial virus hospitalization. | respiratory syncytial virus (rsv) is a leading cause of hospitalization for children <1year old and is more severe in premature infants. | 2015 | 26186560 |
| low eosinophils during bronchiolitis in infancy are associated with lower risk of adulthood asthma. | infant bronchiolitis may be the first manifestation of asthma. | 2015 | 26186154 |
| leptin is oversecreted by respiratory syncytial virus-infected bronchial epithelial cells and regulates th2 and th17 cell differentiation. | infection of human bronchial epithelial cells (hbecs) with respiratory syncytial virus (rsv) has been shown to induce a th lymphocyte subset drift, e.g. enhanced differentiation of th2 and th17 subsets, which is a classic characteristic of asthma. however, the molecules responsible for the drift in th subsets remain unknown. this study aims to determine the expression of leptin in rsv-infected hbecs, and its role in th2 and th17 cell differentiation and extracellular regulated kinase (erk) 1/2 p ... | 2015 | 26184438 |
| 2'-5'-oligoadenylate synthetase-like protein inhibits respiratory syncytial virus replication and is targeted by the viral nonstructural protein 1. | 2'-5'-oligoadenylate synthetase-like protein (oasl) is an interferon-inducible antiviral protein. here we describe differential inhibitory activities of human oasl and the two mouse oasl homologs against respiratory syncytial virus (rsv) replication. interestingly, nonstructural protein 1 (ns1) of rsv promoted proteasome-dependent degradation of specific oasl isoforms. we conclude that oasl acts as a cellular antiviral protein and that rsv ns1 suppresses this function to evade cellular innate im ... | 2015 | 26178980 |
| mammalian cell-derived respiratory syncytial virus-like particles protect the lower as well as the upper respiratory tract. | globally, respiratory syncytial virus (rsv) is a leading cause of bronchiolitis and pneumonia in children less than one year of age and in usa alone, between 85,000 and 144,000 infants are hospitalized every year. to date, there is no licensed vaccine. we have evaluated vaccine potential of mammalian cell-derived native rsv virus-like particles (rsv vlps) composed of the two surface glycoproteins g and f, and the matrix protein m. results of in vitro testing showed that the vlps were functionall ... | 2015 | 26172453 |
| influence of respiratory viruses on the evaluation of the 13-valent pneumococcal conjugate vaccine effectiveness in children under 5 years old: a time-series study for the 2001-2013 period. | s treptococcus pneumoniae is the main agent in bacterial consolidated pneumonias. in 2012, the 13-valent pneumococcal conjugate vaccine was introduced in the argentine national immunization schedule for immunocompetent children as of two months old with a two-dose schedule plus a booster. | 2015 | 26172005 |
| [research progress in the f gene and protein of the respiratory syncytial virus]. | the respiratory syncytial virus (rsv) belongs to the family paramyxoviridae and subfamily pneumovirinae. the rsv can cause acute infections of the lower respiratory tract in infants. the f gene of the rsv is a conservative gene and varies only slightly in its expression. few studies focusing on the variability of the f gene have been carried out. f protein (fusion glycoprotein) is a transmembrane glycoprotein that mediates fusion and penetration between the virus and host cells. neutralizing ant ... | 2015 | 26164949 |
| olfactomedin 4 serves as a marker for disease severity in pediatric respiratory syncytial virus (rsv) infection. | respiratory viral infections follow an unpredictable clinical course in young children ranging from a common cold to respiratory failure. the transition from mild to severe disease occurs rapidly and is difficult to predict. the pathophysiology underlying disease severity has remained elusive. there is an urgent need to better understand the immune response in this disease to come up with biomarkers that may aid clinical decision making. | 2015 | 26162090 |
| sirtuin 1 regulates dendritic cell activation and autophagy during respiratory syncytial virus-induced immune responses. | respiratory syncytial virus (rsv) is the major cause of lower respiratory tract infection in children worldwide. sirtuin 1 (sirt1), an nad(+)-dependent deacetylase, has been associated with the induction of autophagy and the regulation of inflammatory mediators. we found that sirt1 was upregulated in mouse lung after rsv infection. infected animals that received ex-527, a selective sirt1 inhibitor, displayed exacerbated lung pathology, with increased mucus production, elevated viral load, and en ... | 2015 | 26157176 |
| respiratory syncytial virus utilizes a trna fragment to suppress antiviral responses through a novel targeting mechanism. | target identification is highly instructive in defining the biological roles of micrornas. however, little is known about other small noncoding rnas; for example, trna-derived rna fragments (trfs). some trfs exhibit a gene-silencing mechanism distinctly different from that of typical micrornas. we recently demonstrated that a respiratory syncytial virus (rsv)-induced trf, called trf5-gluctc, promotes rsv replication. rsv is the single most important cause of lower respiratory tract infection in ... | 2015 | 26156244 |
| cell-contact dependent inhibition of monocytes by airway epithelial cells and reversion by infection with respiratory syncytial virus. | airway epithelial cells (aec) are the first line of defense against airborne infectious microbes and play an important role in regulating the local immune response. however, the interplay of epithelial cells and professional immune cells during both homeostasis and infection has only been partially studied. the present study was performed to determine how bronchial epithelial cells affect the activation of monocytes. under healthy conditions, aecs were shown to inhibit reactivity of monocytes. w ... | 2015 | 26153873 |
| respiratory syncytial virus infections in pediatric transplant recipients: a canadian paediatric surveillance program study. | the incidence and spectrum of severity of rsv infections in sot or hsct recipients is not known. from september 2010 through august 2013, pediatricians were surveyed monthly by the cpsp for sot or hsct recipients with rsv infection within two yr post-transplant. there were 24 completed case report forms that fit the inclusion criteria (10 hsct and 14 sot recipients). six of 24 cases (25%) remained outpatients, and 11 (46%) were managed on an inpatient ward, while seven (29%) required intensive c ... | 2015 | 26152857 |
| biomarkers of respiratory syncytial virus (rsv) infection: specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity. | despite fundamental advances in the research on respiratory syncytial virus (rsv) since its initial identification almost 60 years ago, recurring failures in developing vaccines and pharmacologic strategies effective in controlling the infection have allowed rsv to become a leading cause of global infant morbidity and mortality. indeed, the burden of this infection on families and health care organizations worldwide continues to escalate and its financial costs are growing. furthermore, strong e ... | 2015 | 26074450 |
| ige anti-respiratory syncytial virus antibodies detected in serum of pediatric patients with asthma. | respiratory syncytial virus (rsv) causes lower respiratory tract disease in infants and young children, and is a public health concern, as is the increase in pediatric asthma. respiratory viral infections may trigger asthma exacerbations. however, it remains unknown whether rsv infection may have a specific association with asthma. total serum ige, and ige- and igg-anti-rsv ab responses were studied in older asthmatic compared with non-asthmatic children (m/f, mean age: 14) (n=30, n=43, respecti ... | 2015 | 26074414 |
| infants born before 32 weeks of gestation or with respiratory disease are most likely to receive palivizumab in the netherlands. | palivizumab is reported to be effective in reducing respiratory syncytial virus hospitalisation. its licensed uses include infants younger than six months of age, born before 35 weeks of gestation or under two years old with congenital heart disease or bronchopulmonary dysplasia. we redressed lack of research in the netherlands by studying whether infants who met the licensed indications received the drug. | 2015 | 26073782 |
| respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of nrf2. | respiratory syncytial virus (rsv) is the most important cause of viral acute respiratory tract infections and hospitalizations in children, for which no vaccine or treatment is available. rsv infection in cells, mice, and children leads to rapid generation of reactive oxygen species, which are associated with oxidative stress and lung damage, due to a significant decrease in the expression of airway antioxidant enzymes (aoes). oxidative stress plays an important role in the pathogenesis of rsv-i ... | 2015 | 26073125 |
| respiratory syncytial virus infection increases chlorine-induced airway hyperresponsiveness. | exposure to chlorine (cl2) damages airway and alveolar epithelia resulting in acute lung injury and reactive airway hyperresponsiveness (ahr) to methacholine. however, little is known about the effect of preexisting respiratory disease on cl2-induced lung injury. by using a murine respiratory syncytial virus (rsv) infection model, we found that preexisting rsv infection increases cl2 (187 ppm for 30 min)-induced lung inflammation and airway ahr at 24 h after exposure (5 days after infection). rs ... | 2015 | 26071553 |
| hypertonic saline for bronchiolitis in infants. | recently, a 1-year-old patient returned from admission in the hospital for bronchiolitis, and the report i received indicated that he was treated with inhaled hypertonic saline, among other treatments. is this therapy recommended for children in the acute care setting? | 2015 | 26071156 |
| novel antigens for rsv vaccines. | respiratory syncytial virus (rsv) remains a leading global cause of infant mortality and adult morbidity. infection, which recurs throughout life, elicits only short-lived immunity. the development of a safe and efficacious vaccine has, thus far, been elusive. recent technological advances, however, have yielded promising rsv vaccine candidates that are based on solving atomic-level structures of surface glycoproteins interacting with neutralizing antibodies. the class i fusion glycoprotein, f, ... | 2015 | 26070108 |
| respiratory syncytial virus in hematopoietic stem cell transplantation and solid-organ transplantation. | respiratory syncytial virus (rsv), one of the most common causes of respiratory infections in immunocompetent individuals, can cause significant pulmonary morbidity and mortality in hematopoietic stem cell (hsct) and less often in solid-organ transplant recipients. early diagnosis and medical intervention prior to the progression from upper to lower respiratory tract viral involvement is essential to positively affect the clinical course. the greatest risk of disease progression from upper to lo ... | 2015 | 26068871 |
| eighteen years of respiratory syncytial virus surveillance: changes in seasonality and hospitalization rates in southwestern alaska native children. | alaska native infants from the yukon-kuskokwim delta (ykd) experienced respiratory syncytial virus (rsv) hospitalization rates 5 times higher and an rsv season twice as long as the general us infant population. we describe trends in hospitalization rates and seasonality during 18 years of continuous rsv surveillance in this population and explore contributions of climate and sociodemographic factors. | 2015 | 26065863 |
| immunological, viral, environmental, and individual factors modulating lung immune response to respiratory syncytial virus. | respiratory syncytial virus is a worldwide pathogen agent responsible for frequent respiratory tract infections that may become severe and potentially lethal in high risk infants and adults. several studies have been performed to investigate the immune response that determines the clinical course of the infection. in the present paper, we review the literature on viral, environmental, and host factors influencing virus response; the mechanisms of the immune response; and the action of nonimmunol ... | 2015 | 26064963 |
| trends of respiratory syncytial virus infections in children under 2 years of age in puerto rico. | the respiratory syncytial virus (rsv) is the most significant viral pathogen causing bronchiolitis and pneumonia in infants, today. in tropical climates the rsv infection may occur throughout the year. the purpose of this study was to asses rsv infections during the 2009‒2010 rsv season in children under 2 years of age and to evaluate the trend of positive rsv tests in the period of 2007 to 2009. | 2015 | 26061061 |
| adult patients with respiratory syncytial virus infection: impact of solid organ and hematopoietic stem cell transplantation on outcomes. | respiratory syncytial virus (rsv) is a common community-acquired pathogen responsible for a substantial disease burden in adults. we investigated the outcomes after rsv infection in hospitalized adults over a 3-year period. | 2015 | 26059180 |
| the danish national prescription registry in studies of a biological pharmaceutical: palivizumab - validation against two external data sources. | national prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. | 2015 | 26056490 |
| characteristics and their clinical relevance of respiratory syncytial virus types and genotypes circulating in northern italy in five consecutive winter seasons. | in order to investigate the genetic diversity and patterns of the co-circulating genotypes of respiratory syncytial virus (rsv) and their possible relationships with the severity of rsv infection, we studied all of the rsv-positive nasopharyngeal samples collected from children during five consecutive winters (2009-2010, 2010-2011, 2011-2012, 2012-2013 and 2013-2014). the rsvs were detected using the respiratory virus panel fast assay and single-tube rt-pcr, their nucleotides were sequenced, and ... | 2015 | 26047100 |
| natural helper cells contribute to pulmonary eosinophilia by producing il-13 via il-33/st2 pathway in a murine model of respiratory syncytial virus infection. | it has been reported that natural helper cells, which are a non-t, non-b innate lymphoid cell type expressing c-kit and st2, mediate influenza-induced airway hyper-reactivity by producing substantial il-13. however, little is known about natural helper cells for the development of rsv-induced airway inflammation, particularly eosinophilic infiltration. by using balb/c mice that were infected intranasally with rsv, it became clear that infection with rsv can induce an increase in the absolute num ... | 2015 | 26044350 |
| resveratrol suppresses persistent airway inflammation and hyperresponsivess might partially via nerve growth factor in respiratory syncytial virus-infected mice. | respiratory syncytial virus (rsv) infection is involved in persistent and recurrent wheezing. there are no effective and safe drugs for the sequelae of persistent wheezing after early bronchiolitis. in this study, we investigated the effect of resveratrol on persistent airway inflammation and airway hyperresponsiveness (ahr) induced by rsv infection. rsv-infected mice were sacrificed at serial time points after infection to collect samples and measure the number of inflammatory cells and levels ... | 2015 | 26044349 |
| incidence, risk factors and hospital burden in children under five years of age hospitalised with respiratory syncytial virus infections. | respiratory syncytial virus (rsv) infections are among the most common lower respiratory tract infections in infants, but few studies have determined the age-specific incidence of hospitalisation in defined populations. this study gathered swedish data on rsv in gothenburg and its 10 surrounding municipalities from 2004 to 2011. | 2015 | 26036725 |
| objectives, design and enrollment results from the infant susceptibility to pulmonary infections and asthma following rsv exposure study (inspire). | respiratory syncytial virus (rsv) lower respiratory tract infection (lri) during infancy has been consistently associated with an increased risk of childhood asthma. in addition, evidence supports that this relationship is causal. however, the mechanisms through which rsv contributes to asthma development are not understood. the inspire (infant susceptibility to pulmonary infections and asthma following rsv exposure) study objectives are to: 1) characterize the host phenotypic response to rsv in ... | 2015 | 26021723 |
| respiratory syncytial virus bronchiolitis in children up to 5 years of age in spain: epidemiology and comorbidities: an observational study. | this epidemiological survey in spain estimates the burden of respiratory syncytial virus (rsv) infection in children up to 5 year of age during a 15-year period (1997-2011). observational retrospective survey was conducted by reviewing data of the national surveillance system for hospital data, including >98% of spanish hospitals. all hospitalizations related to rsv infection for children up to 5 years, reported during 1997-2011 period, were analyzed. codes were selected by using the internation ... | 2015 | 26020386 |
| functional analysis of the 60-nucleotide duplication in the respiratory syncytial virus buenos aires strain attachment glycoprotein. | there are two subgroups of respiratory syncytial virus (rsv), a and b, and within each subgroup, isolates are further divided into clades. several years ago, multiple subgroup b isolates which contained a duplication of 60 nucleotides in the glycoprotein (g) gene were described. these isolates were given a new clade designation of ba based on the site of isolation, buenos aires, argentina. ba rsv strains have since become the predominant circulating clade of rsv b viruses. we hypothesized that t ... | 2015 | 26018171 |
| [prevalence of respiratory syncytial virus infection in hospitalized children at a children's hospital and effects of climate change on the prevalence in suzhou, china]. | to investigate the prevalence of respiratory syncytial virus (rsv) infection in hospitalized children and the relationship between the prevalence and the climate change in suzhou, china. | 2015 | 26014700 |
| antiviral activity of tmc353121, a respiratory syncytial virus (rsv) fusion inhibitor, in a non-human primate model. | the study assessed the antiviral activity of tmc353121, a respiratory syncytial virus (rsv) fusion inhibitor, in a preclinical non-human primate challenge model with a viral shedding pattern similar to that seen in humans, following continuous infusion (ci). | 2015 | 26010881 |
| risk factors for bronchiolitis hospitalization during the first year of life in a multicenter italian birth cohort. | respiratory syncytial virus (rsv) is one of the main causes of respiratory infections during the first year of life. very premature infants may contract more severe diseases and 'late preterm infants' may also be more susceptible to the infection. the aim of this study is to evaluate the risk factors for hospitalization during the first year of life in children born at different gestational ages in italy. | 2015 | 26006025 |
| respiratory syncytial virus inhibitor az-27 differentially inhibits different polymerase activities at the promoter. | respiratory syncytial virus (rsv) is the leading cause of pediatric respiratory disease. rsv has an rna-dependent rna polymerase that transcribes and replicates the viral negative-sense rna genome. the large polymerase subunit (l) has multiple enzymatic activities, having the capability to synthesize rna and add and methylate a cap on each of the viral mrnas. previous studies (h. xiong et al., bioorg med chem lett, 23:6789-6793, 2013, http://dx.doi.org/10.1016/j.bmcl.2013.10.018; c. l. tiong-yip ... | 2015 | 25995255 |
| nk cell immunophenotypic and genotypic analysis of infants with severe respiratory syncytial virus infection. | respiratory syncytial virus (rsv) is the leading cause of severe lower respiratory tract infection in infants. reduced numbers of nk cells have been reported in infants with severe rsv infection; however, the precise role of nk cells during acute rsv infection is unclear. in this study the nk and t cell phenotypes, lilrb1 gene polymorphisms and kir genotypes of infants hospitalized with rsv infection were analyzed. compared to controls, infants with acute rsv infection showed a higher proportion ... | 2015 | 25988502 |
| estimating the hospitalization burden associated with influenza and respiratory syncytial virus in new york city, 2003-2011. | hospitalization burden associated with influenza and respiratory syncytial virus (rsv) is uncertain due to ambiguity in the inference methodologies employed for its estimation. | 2015 | 25980600 |
| discovery of β-d-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial rna and dna polymerases. | novel 4'-substituted β-d-2'-deoxy-2'-α-fluoro (2'd2'f) nucleoside inhibitors of respiratory syncytial virus (rsv) are reported. the introduction of 4'-substitution onto 2'd2'f nucleoside analogs resulted in compounds demonstrating potent cell based rsv inhibition, improved inhibition of the rsv polymerase by the nucleoside triphosphate metabolites, and enhanced selectivity over incorporation by mitochondrial rna and dna polymerases. selectivity over the mitochondrial polymerases was found to be ... | 2015 | 25978965 |
| effect of preexisting serum and mucosal antibody on experimental respiratory syncytial virus (rsv) challenge and infection of adults. | we studied preexisting respiratory syncytial virus (rsv)-specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (ig) a predicted lower infectivity and lower measures of viral replication. however, once individuals were infected, no significant protective effect of preexisting antibodies was seen. lack of correlation b ... | 2015 | 25977264 |
| population-based incidence and etiology of community-acquired neonatal viral infections in bangladesh: a community-based and hospital-based surveillance study. | the etiology of >90% of cases of suspected neonatal infection remains unknown. we conducted community-based surveillance in conjunction with hospital-based surveillance in a rural region in bangladesh from june 2006 to september 2007 to assess the incidence and etiology of community-acquired viral infections among neonates. | 2015 | 25961894 |
| blocking respiratory syncytial virus entry: a story with twists. | respiratory syncytial virus (rsv) is responsible for majority of infant hospitalizations due to viral infections. despite its clinical importance, no vaccine against rsv or effective antiviral therapy is available. several structural classes of small-molecule rsv entry inhibitor have been described and one compound has advanced to clinical testing. mutations in either one of two resistance hot spots in the f protein mediate unusual pan-resistance to all of these inhibitor classes. based on the b ... | 2015 | 25961744 |
| respiratory syncytial virus as a cause of acute respiratory infections in adults. an emerging disease? | 2015 | 25956018 | |
| long-term burden and respiratory effects of respiratory syncytial virus hospitalization in preterm infants-the spring study. | the health status of premature infants born 321-350 weeks' gestational age (wga) hospitalized for rsv infection in the first year of life (cases; n = 125) was compared to that of premature infants not hospitalized for rsv (controls; n = 362) through 6 years. the primary endpoints were the percentage of children with wheezing between 2-6 years and lung function at 6 years of age. secondary endpoints included quality of life, healthcare resource use, and allergic sensitization. a significantly hig ... | 2015 | 25955487 |
| three-weekly doses of azithromycin for indigenous infants hospitalized with bronchiolitis: a multicentre, randomized, placebo-controlled trial. | bronchiolitis is a major health burden in infants globally, particularly among indigenous populations. it is unknown if 3 weeks of azithromycin improve clinical outcomes beyond the hospitalization period. in an international, double-blind randomized controlled trial, we determined if 3 weeks of azithromycin improved clinical outcomes in indigenous infants hospitalized with bronchiolitis. | 2015 | 25954737 |
| discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors. | a series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. the imidazopyridine derivatives were found to have good potency and physical-chemical properties. several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. the most potent compound 8jm showed an ic50 of 3 nm, lower microsome clearance and no cyp inhibition. the profile of 8jm appeared to be superior to bms433771, and supported fur ... | 2015 | 25941547 |
| frequent asymptomatic respiratory syncytial virus infections during an epidemic in a rural kenyan household cohort. | the characteristics, determinants, and potential contribution to transmission of asymptomatic cases of respiratory syncytial virus (rsv) infection have not been well described. | 2015 | 25941331 |
| inhibition of respiratory syncytial virus replication and virus-induced p38 kinase activity by berberine. | respiratory syncytial virus (rsv) causes severe lower respiratory tract infection and poses a major public health threat worldwide. no effective vaccines or therapeutics are currently available; berberine, an isoquinoline alkaloid from various medicinal plants, has been shown to exert antiviral and several other biological effects. recent studies have shown that p38 mitogen-activated protein kinase (mapk) activity is implicated in infection by and replication of viruses such as rsv and the influ ... | 2015 | 25939536 |
| rsv p-protein impairs extrinsic apoptosis pathway in a macrophage-like cell line persistently infected with respiratory syncytial virus. | disabling apoptosis is practically a mandatory step for establishing and maintaining viral persistence in host cells. thus, persisting viruses have evolved strategies to impair apoptosis mechanisms. apoptosis can be induced through either the intrinsic or the extrinsic pathway. previously, we reported that staurosporine-induced intrinsic apoptotic pathway was down-regulated in a macrophage cell line persistently infected with respiratory syncytial virus (rsv, mφp). in the present study, our resu ... | 2015 | 25937519 |
| detection of adenovirus and respiratory syncytial virus in patients with chronic obstructive pulmonary disease: exacerbation versus stable condition. | latent infection with adenovirus and respiratory syncytial virus (rsv) is associated with chronic obstructive pulmonary disease (copd). the role of respiratory viral infections are emerging in copd exacerbations. the present study aimed to investigate the prevalence of adenovirus and rsv serotypes a and b in individuals with acute exacerbations of copd (copd-ae) and stable copd. twenty seven patients with copd-ae were evaluated using a prospective longitudinal study design. induced sputum, sera ... | 2015 | 25936369 |
| addressing a challenge with a challenge. investigating respiratory syncytial virus immunity with the human challenge model. | 2015 | 25932761 | |
| respiratory syncytial virus in children with influenza-like illness. | 2015 | 25929636 | |
| caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection. | respiratory syncytial virus (rsv) infection is recognized by the innate immune system through toll like receptors (tlrs) and retinoic acid inducible gene i. these pathways lead to the activation of type i interferons and resistance to infection. in contrast to tlrs, very few studies have examined the role of nod-like receptors in viral recognition and induction of adaptive immune responses to rsv. caspase-1 plays an essential role in the immune response via the maturation of the proinflammatory ... | 2015 | 25922596 |
| computerized assessment of wheezing in children with respiratory syncytial virus bronchiolitis before and after hypertonic saline nebulization. | studies suggest an effect of nebulized hypertonic saline solution on air-flow limitation in subjects with respiratory syncytial virus (rsv) bronchiolitis, but results are based on subjective scores of clinical severity and are not clear. in this observational study, we used a noninvasive computerized tool to quantify wheezing before and after nebulization with hypertonic saline in children admitted for rsv infection. | 2015 | 25922547 |
| new options in the treatment of respiratory syncytial virus disease. | respiratory syncytial virus (rsv) remains a significant cause of morbidity and mortality in infants, immunocompromised patients and the elderly. despite the high disease burden, an effective vaccine or specific therapy are lacking which is largely due to our limited understanding of the immune response to rsv and how it relates to clinical disease severity. current treatment for rsv remains largely supportive and rsv-specific options for prophylaxis and/or treatment are limited to palivizumab an ... | 2015 | 25922289 |
| respiratory syncytial virus in infants: is maternal vaccination a realistic strategy? | respiratory syncytial virus (rsv) remains an important cause of serious and sometimes fatal acute lower respiratory tract disease in infants, yet no effective antiviral treatment or vaccine for the prevention of rsv in early life is available. vaccination of women during pregnancy is considered to be the most plausible strategy to provide direct rsv antibody protection to young infants during a period of greatest vulnerability. | 2015 | 25918956 |
| the impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis. | the impact of dynamic respiratory syncytial virus (rsv) load on the clinical severity of hospitalized infants with bronchiolitis has not been clarified. nasopharyngeal aspirates were obtained from 60 infants who were diagnosed with bronchiolitis within 96 hr of wheezing onset upon admission and on days 3, 5, and 7 in the hospital, and 17 respiratory viruses were detected. the rsv load was quantified by real-time qpcr for rsv subtypes a and b at different time points. scoring criteria were used t ... | 2015 | 25907780 |
| high viral load and respiratory failure in adults hospitalized for respiratory syncytial virus infections. | a prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). high viral rna concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; d ... | 2015 | 25904604 |
| editorial commentary: can a reduced-dose prophylaxis schedule provide adequate coverage against respiratory syncytial virus infection? | 2015 | 25904371 | |
| reduced-dose schedule of prophylaxis based on local data provides near-optimal protection against respiratory syncytial virus. | respiratory syncytial virus (rsv) is a major cause of respiratory infections among young children and can lead to severe disease among some infants. infants at high risk for severe rsv infection receive monthly injections of a prophylactic monoclonal antibody during the rsv season based on national guidelines. we considered whether a reduced-dose schedule tailored to the local rsv season in the continental united states would provide adequate protection. | 2015 | 25904370 |
| viral coinfection in acute respiratory infection in mexican children treated by the emergency service: a cross-sectional study. | acute respiratory infections (aris) cause illness. children under five years of age are highly vulnerable to these infections. viral coinfection or multiple viral infection is a variable that can have a significant impact on the evolution of these diseases. | 2015 | 25903455 |
| the importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. | viral infection is one of the risk factors for asthma exacerbation. however, which pathogens are related to asthma exacerbation in adults remains unclear. | 2015 | 25901797 |
| alveolar macrophage-derived type i interferons orchestrate innate immunity to rsv through recruitment of antiviral monocytes. | type i interferons (ifns) are important for host defense from viral infections, acting to restrict viral production in infected cells and to promote antiviral immune responses. however, the type i ifn system has also been associated with severe lung inflammatory disease in response to respiratory syncytial virus (rsv). which cells produce type i ifns upon rsv infection and how this directs immune responses to the virus, and potentially results in pathological inflammation, is unclear. here, we s ... | 2015 | 25897172 |
| influenza and other respiratory viruses detected by influenza-like illness surveillance in leyte island, the philippines, 2010-2013. | this study aimed to determine the role of influenza-like illness (ili) surveillance conducted on leyte island, the philippines, including involvement of other respiratory viruses, from 2010 to 2013. ili surveillance was conducted from january 2010 to march 2013 with 3 sentinel sites located in tacloban city, palo and tanauan of leyte island. ili was defined as fever ≥38°c or feverish feeling and either cough or running nose in a patient of any age. influenza virus and other 5 respiratory viruses ... | 2015 | 25893441 |
| structured performance assessment in three pediatric emergency scenarios: a validation study. | to develop and validate 3 performance evaluation checklists (pecs) for systematic performance assessment in 3 clinical scenarios: cardiopulmonary arrest, dyspnea with oxygen desaturation after intubation, and respiratory syncytial virus (rsv). | 2015 | 25890675 |
| host response to respiratory syncytial virus infection. | respiratory syncytial virus (rsv) infection is the leading cause of bronchiolitis and hospitalization in young infants and causes 100, 000-200, 000 deaths annually. there is still no licensed vaccine against rsv infection and the therapeutic options are mainly supportive. despite almost six decades of research, important knowledge gaps remain with respect to the characterization of immune mechanisms responsible for protection and pathogenesis, as well as to the identification of risk factors tha ... | 2015 | 25887611 |