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anti-ischemic effect of curcumin in rat brain.turmeric has been in use since ancient times as a condiment and due to its medicinal properties. curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant property. in view of the novel combination of properties, neuroprotective efficacy of curcumin was studied in rat middle cerebral artery occlusion (mcao) model. rats were subjected to 2 h ...200818204970
inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by artemisia capillaris.anticarcinogenic activity of medicinal herbs (artemisia capillaris, taxus cuspidata, anthriscus sylveatris, and curcuma longa) was examined for 7,12-dimethylbenz[a]anthracene (dmba)-induced mouse skin carcinogenesis. four types of solvent fractions (hexane, chloroform, ethyl acetate, and butanol) were prepared from the methanolic extract of medicinal herbs. the cytotoxicity and anticarcinogenic activities of solvent fractions were examined for mouse leukemia l1210 cancer cells and for female icr ...200818211378
curcumin inhibits glucose production in isolated mice hepatocytes.curcumin is a compound derived from the spice turmeric, and is a potent anti-oxidant, anti-carcinogenic, and anti-hepatotoxic agent. we have investigated the acute effects of curcumin on hepatic glucose production. gluconeogenesis and glycogenolysis in isolated hepatocytes, and gluconeogenetic enzyme activity after 120 min exposure to curcumin were measured. hepatic gluconeogenesis from 1 mm pyruvate was inhibited in a concentration-dependent manner, with a maximal decrease of 45% at the concent ...200818221818
curcumin sensitizes trail-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis.we have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of trail in prostate cancer pc-3 cells, and sensitizes trail-resistant lncap cells in vitro through multiple mechanisms. the objectives of this study were to investigate the molecular mechanisms by which curcumin sensitized trail-resistant lncap xenografts in vivo.200818226269
the chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway.cervical cancer is the second most common malignancy among women worldwide and is highly radioresistant, often resulting in local treatment failure. for locally advanced disease, radiation is combined with low-dose chemotherapy; however, this modality often leads to severe toxicity. curcumin, a polyphenol extracted from rhizomes of the plant curcuma longa, is a widely studied chemopreventive agent that was shown to have a low toxicity profile in three human clinical trials. here, we show that pr ...200818252805
curcumin, a known phenolic from curcuma longa, attenuates the virulence of pseudomonas aeruginosa pao1 in whole plant and animal pathogenicity models.the effect of curcumin on the virulence of pseudomonas aeruginosa (pao1) using whole plant and animal pathogenicity models was investigated. the effect of curcumin on pao1 virulence was studied by employing in vitro assays for virulence factor production, arabidopsis thaliana/caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. it is shown that the curcumin inhibits pao1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, ...200818284200
mycotoxins in botanicals and dried fruits: a review.botanicals are used in many countries for medicinal and general health-promoting purposes. numerous natural occurrences of mycotoxins in botanicals and dried fruits have been reported. aflatoxins or ochratoxin a (ota) have been found in botanicals such as ginseng, ginger, liquorice, turmeric, and kava-kava in the usa, spain, argentina, india, and some other countries, while fumonisins have been found in medicinal wild plants in south africa and in herbal tea and medicinal plants in turkey. zeara ...200818286408
protective effect of curcumin, the active principle of turmeric (curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain.tardive dyskinesia (td) is a motor disorder of the orofacial region resulting from chronic neuroleptic treatment. a high incidence and irreversibility of this hyperkinetic disorder has been considered a major clinical issue in the treatment of schizophrenia. the molecular mechanism related to the pathophysiology of tardive dyskinesia is not completely known. various animal studies have demonstrated an enhanced oxidative stress and increased glutamatergic transmission as well as inhibition in the ...200818022680
effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on wt1 gene expression in leukemic cell lines.leukemias are groups of hematological malignancies with high incidence and mortality rates in patients worldwide. there have been shown in many studies that wilms' tumor1 (wt1) gene were highly expressed in leukemic blast cells. curcuminoids, major active components of the spice turmeric, are well known for its anticancer. curcuminoids consist of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin. in this study, the effect of each curcuminoids'components on wt1 gene expression in leukemi ...200818034345
curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative dna damage in a rat lung epithelial cell line.chronic inhalation of high concentrations of respirable quartz particles has been implicated in various lung diseases including lung fibrosis and cancer. generation of reactive oxygen species (ros) and oxidative stress is considered a major mechanism of quartz toxicity. curcumin, a yellow pigment from curcuma longa, has been considered as nutraceutical because of its strong anti-inflammatory, antitumour and antioxidant properties. the aim of our present study was to investigate whether curcumin ...200818001810
curcumin attenuates dimethylnitrosamine-induced liver injury in rats through nrf2-mediated induction of heme oxygenase-1.curcumin (diferuloymethane), a yellow colouring agent present in the rhizome of curcuma longa linn (zingiberaceae), has been reported to possess anti-inflammatory, antioxidant, antimutagenic and anticarcinogenic activities. curcumin exerts its chemoprotective and chemopreventive effects via multiple mechanisms. it has been reported to induce expression of the antioxidant enzymes in various cell lines. heme oxygenase-1 (ho-1) is an important antioxidant enzyme that plays a pivotal role in cytopro ...200818006204
curcumin protects the rat liver from ccl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.we previously demonstrated that curcumin, a polyphenolic antioxidant purified from turmeric, up-regulated peroxisome proliferator-activated receptor (ppar)-gamma gene expression and stimulated its signaling, leading to the inhibition of activation of hepatic stellate cells (hsc) in vitro. the current study evaluates the in vivo role of curcumin in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (ccl(4)) in rats and further explores the underlying mechanisms. w ...200818006644
curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain.turmeric is a source of numerous aromatic compounds isolated from powdered rhizomes of curcuma longa linn. the constituents are present as volatile oil, the curcuma oil (c.oil), semi-solid oleoresins and non-volatile compounds such as curcumin. a rapidly expanding body of data provides evidence of the anti-cancer action of curcumin, and most importantly in the present context, its neuroprotective activity. almost nothing is known about such activity of c.oil. we report that c.oil (500 mg kg(-1) ...200817955367
curcumin prevents and reverses murine cardiac hypertrophy.chromatin remodeling, particularly histone acetylation, plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. we hypothesized that curcumin, a natural polyphenolic compound abundant in the spice turmeric and a known suppressor of histone acetylation, would suppress cardiac hypertrophy through the disruption of p300 histone acetyltransferase-dependent (p300-hat-dependent) transcriptional activation. we tested this hypothesis using primary cultured rat car ...200818292803
the dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.hemodynamic overload in the heart can trigger maladaptive hypertrophy of cardiomyocytes. a key signaling event in this process is nuclear acetylation by histone deacetylases and p300, an intrinsic histone acetyltransferase (hat). it has been previously shown that curcumin, a polyphenol responsible for the yellow color of the spice turmeric, possesses hat inhibitory activity with specificity for the p300/creb-binding protein. we found that curcumin inhibited the hypertrophy-induced acetylation an ...200818292809
traditional indian spices and their health significance.india has been recognized all over the world for spices and medicinal plants. both exhibit a wide range of physiological and pharmacological properties. current biomedical efforts are focused on their scientific merits, to provide science-based evidence for the traditional uses and to develop either functional foods or nutraceuticals. the indian traditional medical systems use turmeric for wound healing, rheumatic disorders, gastrointestinal symptoms, deworming, rhinitis and as a cosmetic. studi ...200818296352
early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets.curcumin (diferuloyl), from the indian spice turmeric, reduces oxidative damage and induces apoptosis. utilizing dna microarrays, we have demonstrated that a low (5 microm) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (c6 rat glioma cells) in culture for 24 and 48 h significantly modulates gene expression in four primary pathways: oxidative stress, cell cycle control, and dna transcription and metabolism. contribution of the pentose phosphate pathway to the pool of nadh ...200818299980
curcumin: from ancient medicine to current clinical trials.curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (curcuma longa). curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. the pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by nf-kappab, akt, and growth factors; cytopr ...200818324353
cyto-protective and immunomodulating effect of curcuma longa in wistar rats subjected to carbon tetrachloride-induced oxidative stress.a comparison of crude curcuminoid extract and purified curcumin was made to evaluate hepato- and immunoprotective effect of curcuma longa (turmeric) zingiberaceae. carbon tetrachloride (ccl4) induced cellular hepatic damage was evaluated by transmission electron microscopy, hepatic enzymes and thiobarbituric acid reactive species (tbar) values. a selective cytolytic effect of ccl4 was observed among immature (pna+) thymocytes and peripheral helper (cd4+) t lymphocytes in spleen and was parallele ...200818340409
effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.curcumin, a well-known dietary pigment derived from curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the g2/m phase. the anti-apoptotic bcl-2 and survivin ...200818342436
curcumin (diferuloylmethane) alters the expression profiles of micrornas in human pancreatic cancer cells.a major challenge in cancer chemotherapy has been developing safe and clinically efficacious chemotherapeutic agents. with its low toxicity profile, curcumin (diferuloylmethane), a naturally occurring flavinoid derived from the rhizome of curcuma longa, has great promise. in vitro and in vivo preclinical studies have shown its inhibitory anticancer, antioxidant, anti-inflammatory, antiproliferative, and proapoptotic activities. the multiple mechanisms of the antitumor effect of curcumin putative ...200818347134
curcumin: preventive and therapeutic properties in laboratory studies and clinical trials.curcumin is a natural polyphenol used in ancient asian medicine. since the first article referring to the use of curcumin to treat human disease was published in the lancet in 1937, >2,600 research studies using curcumin or turmeric have been published in english language journals. the mechanisms implicated in the inhibition of tumorigenesis by curcumin are diverse and appear to involve a combination of antiinflammatory, antioxidant, immunomodulatory, proapoptotic, and antiangiogenic properties ...200818370854
effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes.curcumin is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. tetrahydrocurcumin (thc) is one of the major metabolites of curcumin, and exhibits many of the same physiological and pharmacological activities as curcumin and, in some systems, may exert greater antioxidant activity than curcumin. using circulating erythrocytes as the cellular mode, the insulin-binding effect of thc and curcumin was investigated. streptozotocin ( ...200818376071
curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappab-regulated gene products.how colorectal cancer develops resistance to gamma-radiation is not fully understood, but the transcription factor nuclear factor-kappab (nf-kappab) and nf-kappab-regulated gene products have been proposed as mediators. because curcumin, a component of turmeric (curcuma longa), has been shown to suppress nf-kappab activation, whether it can sensitize the colorectal cancer to gamma-radiation was investigated in colorectal cancer xenografts in nude mice.200818381954
multi-targeted therapy by curcumin: how spicy is it?although traditional medicines have been used for thousands of years, for most such medicines neither the active component nor their molecular targets have been very well identified. curcumin, a yellow component of turmeric or curry powder, however, is an exception. although inhibitors of cyclooxygenase-2, her2, tumor necrosis factor, egfr, bcr-abl, proteosome, and vascular endothelial cell growth factor have been approved for human use by the united states food and drug administration (fda), cu ...200818384098
effects of spice constituents on p-glycoprotein-mediated transport and cyp3a4-mediated metabolism in vitro.the effects of eight components from six commonly consumed spices on p-glycoprotein (p-gp) transport and cyp3a4 metabolism were evaluated in vitro. p-gp-mediated [(3)h]digoxin fluxes across the l-mdr1 (llc-pk1 cells transfected with human mdr1 gene) and caco-2 (human colon carcinoma) cell monolayers showed a marked asymmetry compared with that in the llc-pk1 (porcine kidney epithelial cells) cell monolayers. curcumin (from turmeric) at 30 to 60 microm and 6-gingerol (from ginger) at 100 to 500 m ...200818385293
plant crude extracts could be the solution: extracts showing in vivo antitumorigenic activity.screening active compounds from plants lead to discover new medicinal drugs which have efficient protection and treatment roles against various diseases including cancer. in our study, extracts from different plants represent seeds of: gossypium barbadense, ricinus communis, sesamum indicum, nigella sativa, vinca rosea and melia azedarah; fruits of: xanthium occidental; flowers of: atriplex nummularia; barks of: cinnamomum zeylanicum; latex of: ficus carica and rhizomes of: curcuma longa and zin ...200818390447
inhibition of nod2 signaling and target gene expression by curcumin.nod2 is an intracellular pattern recognition receptor that detects a conserved moiety of bacterial peptidoglycan and subsequently activates proinflammatory signaling pathways. mutations in nod2 have been implicated to be linked to inflammatory granulomatous disorders, such as crohn's disease and blau syndrome. many phytochemicals possess anti-inflammatory properties. however, it is not known whether any of these phytochemicals might modulate nod2-mediated immune responses and thus might be of th ...200818413660
curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating trkb.curcumin is a major active component isolated from curcuma longa. previously, we have reported its significant antidepressant effect. however, the mechanisms underlying the antidepressant effects are still obscure. in the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of brain-derived neurotrophic factor (bdnf), which is deeply involved in the etiology and treatment of depression. ex ...200818420184
the anti-inflammatory effects of curcuma longa and berberis aristata in endotoxin-induced uveitis in rabbits.to investigate the anti-inflammatory effect of topical application of curcuma longa (c. longa) and berberis aristata (b. aristata) aqueous extracts on experimental uveitis in the rabbit.200818421073
antioxidant and iron-binding properties of curcumin, capsaicin, and s-allylcysteine reduce oxidative stress in rat brain homogenate.research demonstrates that antioxidants and metal chelators may be of beneficial use in the treatment of neurodegenerative diseases, such as alzheimer's disease (ad). this study investigated the antioxidant and metal-binding properties of curcumin, capsaicin, and s-allylcysteine, which are major components found in commonly used dietary spice ingredients turmeric, chilli, and garlic, respectively. the dpph assay demonstrates that these compounds readily scavenge free radicals. these compounds si ...200818422331
[effect of zedoary turmeric oil on proliferation, apoptosis and extracellular matrix secretion of hepatic stellate cells]. 200818423156
curcumin induces apoptosis in hct-116 human colon cancer cells in a p21-independent manner.several micronutrients present in fruits and vegetables exhibit anticancer activity as a result of their actions on molecular targets involved in carcinogenesis and tumor progression. curcumin, a phenolic phytochemical derived from the rhizome of curcuma longa, exhibits both cancer-preventative activity and growth inhibitory effects on neoplastic cells. several studies report that curcumin inhibits cancer cell proliferation and induces apoptosis in cancer cells through p21-mediated cell cycle ar ...200818423603
mosquito larvicidal activity of botanical-based mosquito repellents.the larvicidal activity of 4 plant essential oils--innamon oil, lemon eucalyptus oil, sandalwood oil, and turmeric oil--previously reported as insect repellents was evaluated in the laboratory against 4th instars of aedes albopictus, ae. aegypti, and culex pipiens. sandalwood oil appeared to be the most effective of the larvicides, killing larvae of all 3 mosquito species in relatively short times. the values of lt50 and lt90 at the application dosage (0.2 mg/ml) were 1.06 +/- 0.11 and 3.24 +/- ...200818437833
preparation and characterization of herbal creams for improvement of skin viscoelastic properties.the aim of this study was to formulate and evaluate herbal cosmetic creams for their improvement of skin viscoelastic and hydration properties. the cosmetic cream formulations were designed by using ethanolic extracts of glycyrriza glabra, curcuma longa (roots), seeds of psorolea corlifolia, cassia tora, areca catechu, punica granatum, fruits of embelica officinale, leaves of centella asiatica, dried bark of cinnamon zeylanicum and fresh gel of aloe vera in varied concentrations (0.12-0.9%w/w) a ...200818452435
effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects.high oxalate intake resulting from consuming supplemental doses of cinnamon and turmeric may increase risk of hyperoxaluria, a significant risk factor for urolithiasis.200818469248
curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.because most cancers are caused by dysregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their expression and activity. these include inflammatory cytokines and enzymes, transcription factors, and gene products linked with cell survival, proliferation, invasion, and angiogenesis. curcumin has b ...200818479807
curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury.the antioxidant activity of c.oil in cerebral stroke has been reported earlier. we have attempted here to clarify the mechanisms underlying the neuroprotection against experimental cerebral ischemia by curcuma oil (c.oil), isolated from the rhizomes of curcuma longa. c.oil (250 mg/kg i.p.) was given 30 min before focal ischemia in rats caused by occlusion of the middle cerebral artery (1h of occlusion, 24h of reflow). ischemia, leads to elevation in [ca(2+)] this sets into motion a cascades of i ...200818485279
curcumin inhibits wehi-3 leukemia cells in balb/c mice in vivo.curcumin (1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5- dione), a natural polyphenol product of the plant curcuma longa, exhibited potent inhibitory activities against proliferation, induced cell cycle arrest and exhibited the induction of apoptosis in several tumor cell lines. in our previous studies, we have shown that curcumin induced cell cycle arrest and apoptosis on human leukemia hl-60 and mouse leukemia wehi-3 cells; there are no reports regarding whether or not it affects leuk ...200818396784
curcumin inhibits btrek-1 k+ channels and stimulates cortisol secretion from adrenocortical cells.bovine adrenal zona fasciculata (azf) cells express btrek-1 k(+) channels that set the resting membrane potential. inhibition of these channels by adrenocorticotropic hormone (acth) is coupled to membrane depolarization and cortisol secretion. curcumin, a phytochemical with medicinal properties extracted from the spice turmeric, was found to modulate both btrek-1 k(+) currents and cortisol secretion from azf cells. in whole-cell patch clamp experiments, curcumin inhibited btrek-1 with an ic(50) ...200818406348
new mechanisms and therapeutic potential of curcumin for colorectal cancer.curcumin is a polyphenol derived from curcuma longa. over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. more recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. in fact, preclinical studies have shown its ability ...200818655004
curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.epilepsy is one of the most common serious disorders of the brain. several experimental studies have reported neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. the present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200 mg/kg, orally (p.o.) and its chronic (x 21 days) administration in 100 mg/kg, p.o. on increasing current electroshock (ices) test, elevated plus maze and acto ...200818661468
potential of resveratrol in anticancer and anti-inflammatory therapy.phytochemicals present in food have shown significant prospects in the treatment and management of a vast array of human diseases. resveratrol is a stilbene-type aromatic phytoalexin predominantly found in grapes, peanuts, berries, turmeric, and other food products. resveratrol has been reported to exhibit several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans. anticancer activity of this compound is ...200818667005
ef24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits hif-1.curcumin, the yellow pigment of the spice turmeric, has emerged as a promising anticancer agent due to its antiproliferative and antiangiogenic properties. however, the molecular mechanism of action of this compound remains a subject of debate. in addition, curcumin's low bioavailability and efficacy profile in vivo further hinders its clinical development. this study focuses on the mechanism of action of ef24, a novel curcumin analog with greater than curcumin biological activity and bioavailab ...200818682687
[effect of zedoary turmeric oil-eluting stents for post-stenting restenosis prevention and treatment].to investigate the effect and safety of zedoary turmeric oil (zto)-eluting stents for post-coronary stenting restenosis prevention and treatment in the experimental dogs.200818543486
pharmacokinetics of curcumin conjugate metabolites in healthy human subjects.curcumin is a polyphenol, found in the spice turmeric, that has promising anticancer properties, but previous studies suggest that absorption of curcumin may be limited.200818559556
curcumin protected pc12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.one of the pathological hallmarks of alzheimer's disease is the progressive accumulation of beta-amyloid (abeta) in the form of senile plaques, and abeta insult to neuronal cells has been identified as one of the major causes of the onset of the disease. curcumin, the major and most active antioxidant of curcuma longa, protects neuronal cells against abeta-induced toxicity. therefore, in this study, we investigated the neuroprotective mechanisms by which curcumin acts against abeta (25-35)-induc ...200818573304
possible nitric oxide modulation in protective effect of (curcuma longa, zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice.sleep is essential for the physical and mental health of a human being. problems of sleep deprivation are increasing in modern society nowadays. recently, various antioxidants have been implicated as neuroprotectants in the treatment of stress and stress related problems. the present study was designed to explore the possible role of nitric oxide in the protective effect of curcumin (curcuma longa, zingiberaceae) against 72-h sleep deprivation-induced behavioral alterations and oxidative damage ...200818586477
curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against ccl4-induced liver injury in rats.curcumin and saikosaponin a, the bioactive phytochemicals of turmeric and bupleurum, act as antioxidants. this study investigated the effects of supplementation with curcumin and/or saikosaponin a on hepatic lipids and antioxidant status in rats with ccl(4)-induced liver injury. male sprague-dawley rats were randomly divided into control, ccl(4), ccl(4) + curcumin (0.005%; cu), ccl(4) + saikosaponin a (0.004%; ss), and ccl(4) + curcumin + saikosaponin a (0.005% + 0.004%; cu+ss) groups. ccl(4) (4 ...200818598162
bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of vcam-1 expression.bisacurone, one of the active compounds of the traditionally used indigenous herb curcuma longa linne (zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities. we studied how the level of vascular cell adhesion molecule-1 (vcam-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (tnf-alpha)-activated human umbilical vein endothelial cells (huvecs). b ...200818602074
dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.curcumin (diferuloylmethane), an active ingredient of turmeric, obtained from the powdered rhizomes of curcuma longa linn., has been traditionally recognized for treatment of several diseases. to evaluate the potential clinical use of curcumin, we determined the dose dependence of its effects in the therapeutic window and of the neuroprotective efficacy in a cerebral thromboembolic model of the rat. rats were subjected to occlusion of the middle cerebral artery (mcao) by a thrombus and treated w ...200818611416
calebin-a induces apoptosis and modulates mapk family activity in drug resistant human gastric cancer cells.this study is the first to investigate calebin-a, a natural compound present in curcuma longa, which inhibits cell growth and induce apoptosis in sgc7901/vincristine cells, a multidrug resistant (mdr) human gastric adenocarcinoma cell line. our data suggest the drug efflux function of p-glycoprotein was inhibited by calebin-a treatment, while the expression level of p-glycoprotein was not affected. additionally, co-treatment of calebin-a and vincristine resulted in a remarkable reduction in s ph ...200818619958
[analytical method for carbamate pesticides in processed foods by lc/ms/ms].a rapid analytical method for the simultaneous determination of carbamate pesticides in processed foods was established by liquid chromatography coupled with tandem mass spectrometry (lc/ms/ms). the pesticides were extracted from samples with acetonitrile using accelerated solvent extract equipment, except for the fine powder type spices, which were extracted in an ultrasonic bath. the crude extract was cleaned up with a multi-solvent gpc column (shodex asahipak gf-310 hq) using acetonitrile as ...200818633196
curcumin prevents human dendritic cell response to immune stimulants.curcumin, a compound found in the indian spice turmeric, has anti-inflammatory and immunomodulatory properties, though the mechanism remains unclear. dendritic cells (dcs) are important to generating an immune response and the effect of curcumin on human dcs has not been explored. the role curcumin in the dc response to bacterial and viral infection was investigated in vitro using lps and poly i:c as models of infection. cd14(+) monocytes, isolated from human peripheral blood, were cultured in g ...200818639521
evaluation of widely consumed botanicals as immunological adjuvants.many widely used botanical medicines are claimed to be immune enhancers. clear evidence of augmentation of immune responses in vivo is lacking in most cases. to select botanicals for further study based on immune enhancing activity, we study them here mixed with antigen and injected subcutaneously (s.c.). globo h and gd3 are cell surface carbohydrates expressed on glycolipids or glycoproteins on the cell surface of many cancers. when conjugated to keyhole limpet hemocyanin (klh), mixed with an i ...200818640165
a poly-herbal formulation accelerates normal and impaired diabetic wound healing.in the present study, a poly-herbal formulation (phf) was prepared by combining the aqueous lyophilized leaf extracts of hippophae rhamnoides l. and aloe vera l. and the ethanol rhizome extract of curcuma longa l., in an optimized ratio (1 : 7 : 1). the efficacy of phf treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. topical phf treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced ...200819128249
[comparison and correlative analysis of trace elements in five kinds of radix curcumae].traditional chinese medicine materials (tcm) contained abundant trace elements needed in human body. mixed acid (hno3:hclo4) was added into samples treated by microwave digestion, and a systematic study was carried out by selection of the most appropriate working conditions and optimization of the sample mass. some inorganic elements in 5 kinds of radix curcumae (curcuma wenyujin y. h. chen et c. ling, curcuma longa l., curcuma kwangsiensis s. g. lee et c. f. liang, curcuma phaeocaulis val. and ...200819093592
curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by stat-3 signaling.curcumin (from the rhizome of curcuma longa) is well documented for its medicinal properties in indian and chinese systems of medicine where it is widely used for the treatment of several diseases. epidemiological observations are suggestive that curcumin consumption may reduce the risk of some form of cancers and provide other protective biological effects in humans. these biological properties have been attributed to curcuminoids that have been widely studied for their anti-inflammatory, anti- ...200819116450
involvement of na(+)-ca (2+) exchanger in the endothelium-independent vasorelaxation induced by curcuma longa l. in isolated rat superior mesenteric arteries.previous studies confirmed that the methanolic extract from curcuma longa l. (clme) lowers arterial blood pressure and heart rate in rats due to the blockade of extracellular ca(2+) influx. the aim of this study was to investigate the involvement of na(+)-ca (2+) exchanger in the vasorelaxant effects elicited by clme in isolated rat superior mesenteric arteries. clme (1-1,000 microg/ml) concentration-dependently relaxed phenylephrine (phe) (10 microm) pre-contracted arterial rings with intact-en ...200819122379
epidemiology of animal bites and rabies cases in india. a multicentric study.rabies, a disease of antiquity continues to be a major public health problem in india. multiple factors contribute to high mortality and morbidity due to animal bites. an effective strategy for control of rabies takes into account the epidemiology of animal bites, rabies and factors influencing post exposure treatment. the study was carried out as a part of agreement for performance of work (apw) from world health organization (who) during the period april 2001 to september 2002. two sets of pro ...200819127666
curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells.hepatic stellate cells (hscs) undergo activation and transdifferentiation to myofibroblast like cells in liver injury, leading to liver fibrosis. during recovery from injury, activated hscs may either revert back to quiescent state or undergo apoptosis or both. in the present study, we have examined whether recovery from hepatic injury involves apoptosis of activated hscs and tested whether curcumin (the yellow pigment from curcuma longa linn.) promotes recovery from hepatic injury by inducing a ...200819069843
curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.diabetes exacerbates neuronal injury induced by hyperglycemia mediated oxidative damage and mitochondrial dysfunction. the aim of the present study is to investigate the effects of curcuminoids, polyphenols of curcuma longa (l.) on oxidative stress and mitochondrial impairment in the brain of streptozotocin (stz)-induced diabetic rats. a marked increase in lipid peroxidation and nitrite levels with simultaneous decrease in endogenous antioxidant marker enzymes was observed in the diabetic rat br ...200819031318
biological activities of curcumin and its analogues (congeners) made by man and mother nature.curcumin, a yellow pigment present in the indian spice turmeric (associated with curry powder), has been linked with suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and neurological systems, of skin, and of liver; loss of bone and muscle; depression; chronic fatigue; and neuropathic pain. the utility of curcumin is limited by its color, lack of water solubility, and relatively low in vivo bioavailability. because of the multiple ther ...200818775680
in vivo effects of pain relieving plaster on closed soft tissue injury in rabbit ears.soft tissue injury imposes major public health burdens worldwide. the positive effect of china's tibetan medicine and the lamiophlomis rotata-based herbal pain relieving plaster (prp) on healing closed soft tissue injury (csti) has been reported. the herbs contained in plaster are also referred as 'blood-activating and stasis-dispelling' in herbal medicine. the formula of the plaster contains four china's tibetan medical herbs, including lamiophlomis rotata, oxytropis falcate bunge, curcuma long ...200818793392
curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.curcumin (diferuloylmethane) is the major active ingredient of turmeric (curcuma longa) used in south asian cuisine for centuries. curcumin has been shown to inhibit the growth of transformed cells and to have a number of potential molecular targets. however, the essential molecular targets of curcumin under physiologic conditions have not been completely defined. herein, we report that the tumor cellular proteasome is most likely an important target of curcumin. nucleophilic susceptibility and ...200818794115
curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor hlj1.curcumin (diferuloylmethane) is an active component of the spice turmeric and has a diversity of antitumor activities. in this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor dnaj-like heat shock protein 40 (hlj1). human lung adenocarcinoma cells (cl1-5) treated with curcumin (1-20 mumol/l) showed a concentration-dependent reduction in cell migration, invasion, and metastatic ability, and this was associated with increased ...200818794131
the effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats.in the present study, the effect of chronic oral administration of curcumin in the presence or absence of morphine and noloxone was investigated on the visceral nociception induced by acetic acid in rats. intraperitoneal injection of acetic acid (1 ml, 2%) produced contractions in the abdominal musculature (writhes). the latency time to the beginning of the first writhe was measured and the total number of writhes in the 1 h after acetic acid injection was counted. the latency time to the beginn ...200818817212
neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model.among the naturally occurring compounds, turmeric from the dried rhizome of the plant curcuma longa has long been used extensively as a condiment and a household remedy all over southeast asia. turmeric contains essential oil, yellow pigments (curcuminoids), starch and oleoresin. the present study was designed for investigating the neuroprotective efficacy and the time window for effective therapeutic use of curcuma oil (c. oil).200818826584
comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide.microglia are the resident innate immune cells in the central nervous system. evidence supports that the unregulated activation of microglia results in the production of pro-inflammatory cytokines and chemokines that propagate neuronal injury and finally cause neurodegenerative diseases. curcuminn (cur), demethoxycurcumin (dmc), and bisdemethoxycurcumin (bdmc) are curcuminoid pigments extracted from turmeric (curcuma longa l.). cur has been reported to suppress the activation of microglia by red ...200818838107
anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from porphyromonas gingivalis.porphyromonas gingivalis, a major periodontopathic bacterium, is necessary for periodontitis to take place. the lipopolysaccharide (lps) of p. gingivalis stimulates cytokine secretion in immune cells, and thereby initiates the inflammation related to periodontitis. macrophages are the important ones of the immune cells that are prominent at inflammatory periodontal sites. curcumin, a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory properties. the aim of this study was t ...200818849645
screening of korean medicinal plants for possible osteoclastogenesis effects in vitro.bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. bone resorption and loss are generally attributed to osteoclasts. differentiation of osteoclasts is regulated by receptor activator of nuclear factor nf-kb ligand (rankl), a member of tumor necrosis factor family. when the balance is disturbed, pathological bone abnormality ensues. through the screening of traditional korean medicinal plants, the effective molecules for ...200818850234
histological evaluation of curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog.the experimental finding of asian traditional medicine revealed the pharmacological effect of the local application of ghee which was taken from cow butterfat and the rhizomes of curcuma longa. these materials significantly improved the healing process of the wound. in addition, ancient physicians of middle east discovered that the powdered rhizomes of curcuma longa (common turmeric) also had impressive medicinal qualities. over the centuries, this spice has been used as a pain relieving, anti-i ...200818929638
differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes.curcumin (cur) is a major component of a dietary spice derived from the roots of curcuma longa. it has strong antioxidant activities and hepatoprotective properties. primary human hepatocytes are clinically used in transplantation or in bioartificial liver devices for the treatment of patients with liver failure. fresh and cryopreserved hepatocytes are also used in vitro for the study of drugs in pharmacotoxicology. we aimed to assess whether cur could improve human liver cell viability and prev ...200818697189
influence of food acidulants and antioxidant spices on the bioaccessibility of beta-carotene from selected vegetables.four common food acidulants--amchur, lime, tamarind, and kokum--and two antioxidant spices--turmeric and onion--were examined for their influence on the bioaccessibility of beta-carotene from two fleshy and two leafy vegetables. amchur and lime generally enhanced the bioaccessibility of beta-carotene from these test vegetables in many instances. such an improved bioaccessibility was evident in both raw and heat-processed vegetables. the effect of lime juice was generally more pronounced than tha ...200818729454
antidepressant activity of curcumin: involvement of serotonin and dopamine system.curcumin is a major active principle of curcuma longa, one of the widely used preparations in the indian system of medicine. it is known for its diverse biological actions.200818766332
efficacy of turmeric (curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks.a 3-wk feeding study was conducted to evaluate the efficacy of turmeric (curcuma longa) powder (tmp), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate (hscas; improved milbond-tx, imtx, an adsorbent, milwhite inc., houston, tx) to ameliorate the adverse effects of aflatoxin b(1) (afb(1)) in broiler chicks. four pen replicates of 5 chicks each were assigned to each of 7 dietary treatments, which included the basal diet not containing tmp, hscas, or afb(1) (contr ...200818493001
in vitro and in vivo studies of the use of some medicinal herbals against the pathogen aeromonas hydrophila in goldfish.aeromonas hydrophila is a ubiquitous and opportunistic bacterial pathogen that produces ulcerative dermatitis under stress conditions and inflicts severe losses on global fisheries and fish culture. this study evaluates the antimicrobial potency of aqueous and ethanolic decoction (individual extract) and concoction (mixed extract) of three common medicinal herbs, turmeric curcuma longa, tulsi plant ocimum sanctum, and neem azadirachta indica, against the in vitro growth of a. hydrophila. among t ...200818942593
demethoxycurcumin and its semisynthetic analogues as antitubercular agents.demethoxycurcumin, isolated from the rhizomes of curcuma longa, was found to possess antitubercular activity against mycobacterium tuberculosis h (37)rv strain at 200 microg/ml. derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (mic) value of 7.8 microg/ml. h (37)rv:mycobacterium tuberculosis h (37)rv strain mic:minimum inhibitory concentration.200818991209
comparative assessment of total phenolic content in selected medicinal plants.this study was to compare the total phenolic (tp) content in extracts from eleven plant materials collected at different geographical locations in kenya, nigeria, and usa. these plants have been selected because the majority of them are highly pigmented, from yellow to purple, and would therefore have economic value in industries for producing antioxidants and surfactants. two of them were collected from the industrial and domestic waste outlets. each analysis was achieved using the folin-ciocal ...200820119491
anti-tumor activity of four ayurvedic herbs in dalton lymphoma ascites bearing mice and their short-term in vitro cytotoxicity on dla-cell-line.the anti-tumor activity and chemopreventive potential of four ayurvedic herbs viz. curcuma longa l., ocimum sanctum l., tinospora cordifolia (wild) miers ex hook.f & thomas and zizyphus mauritiana lam. were evaluated using dalton lymphoma ascites (dla) tumor model in swiss albino mice. the outcome was assessed using survival time, peritoneal ascitic fluid (tumor volume) and hematological indices as parameters. animals were divided into five groups (n = 6) viz. one dla control and four herb + dla ...200820161965
a pilot cross-over study to evaluate human oral bioavailability of bcm-95cg (biocurcumax), a novel bioenhanced preparation of curcumin.curcumin, the bioactive component of turmeric, curcuma longa has an exceptionally wide spectrum of activities including antioxidant, anti-inflammatory and anti-cancer properties, and is currently under different phases of clinical trials for various types of soft tissue cancers. however, although in vitro and animal studies have shown anticancer activities of curcumin for virtually all types of human cancers, its poor bioavailability in the human body has severely limited its application to thes ...200820046768
potential effect of curcuma longa extract on infectivity and pathogenicity of schistosoma mansoni cercariae.batch of freshly shed cercariae from infected laboratory bred biomphalaria alexandrina were exposed to different sub-lethal concentrations of turmeric extract for an hour and divided into two groups. the first one was to study the ultrastructural changes induced in them using scanning electron microscopy (sem). the second group was to study infectivity and pathogenicity of the exposed cercariae. one hundred and fifty mice were divided into 5 groups: gi: infected by normal cercariae and served as ...200819143127
effects of curcumin on n-bis(2-hydroxypropyl) nitrosamine (dhpn)-induced lung and liver tumorigenesis in balb/c mice in vivo.curcumin (diferuloylmethane), a phenolic compound from the plant curcuma longa (linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. in this study, curcumin was evaluated in balb/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with n-bis(2-hydroxypropyl)nitrosamine (dhpn). animals were treated with dhpn in water for approximately 14 days before m ...200819181006
two methods for attenuating toxoplasma gondii tachyzoites rh strain by using ethanol extract of curcuma longa.the ethanol extract of curcuma longa proved to be an attenuated agent against toxoplasma gondii (rh strain) tachyzoites in the mice peritoneal fluid by two incubation methods. groups of female mice were injected by attenuated tachyzoites as 200 tachyzoites / ml, which treated with the ethanol extract of curcuma longa was previously treated. the result was observed after one week, as no tachyzoites were found in the peritoneal fluid of the experimental infected mice.200819209778
tea polyphenols and their roles in cancer prevention and chemotherapy.many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. the more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these "natural gifts" for the prevention and treatment of huma ...200819325799
curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma u266 cells.growth of multiple myeloma cells is controlled by various factors derived from host bone marrow microenvironments. interaction between multiple myeloma cells and bone marrow stromal cells (bmscs) plays an important role in the expression of adhesive molecules and secretion of growth factors involved in multiple myeloma (mm) cell growth, survival, and resistance to anticancer drugs. recently, the possibility of developing novel anti-cancer therapeutic strategies targeting both mm cells and mm cel ...200819383353
a simple 2-directional high-performance thin-layer chromatographic method for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and curry powders.a method using simple extraction and 2-directional high-performance thin-layer chromatography (hptlc) was developed for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and various mixed curry powder formulations. the method offers resolution (rf) of turmeric pigments, namely, curcumin (0.77), demethoxycurcumin (0.69), bis(demethoxy)curcumin (0.61), and the synthetic dye metanil yellow (0.05) by the first-directional mobile phase, chloroform-methanol ...200819202799
anti-inflammatory ingredients.there is a growing public awareness and concern among individuals regarding the condition of their skin, with a concomitant desire to use natural products to treat skin conditions. the increased interest in these products has spurred scientific and clinical studies evaluating the composition and clinical usefulness of natural products in the treatment of inflammatory skin dermatoses. there are numerous natural ingredients that have been demonstrated to possess anti-inflammatory properties that m ...200818681154
novel artemisinin and curcumin micellar formulations: drug solubility studies by nmr spectroscopy.artemisinin, a potent antimalarial drug derived from artemisia annua l., and curcumin, a polyphenol extracted from the roots of curcuma longa l., are reported to exert a synergistic antimalarial action, albeit manifesting a low bioavailability. in fact, both these molecules are poorly soluble in aqueous environments. in this study, we report a dosy investigation of the solubilisation capacity of micelles of sodium dodecyl sulphate (sds) for artemisinin and curcumin, individually and in combinati ...200919199296
in vivo effect of some home spices extracts on the toxoplasma gondii tachyzoites.toxoplasmosis drugs have the longest history and are still the first choice for most conditions. alternative drugs such as co-trimoxazole and tetracycline have been tried and acclaimed successful. the lack of general acceptance, however, is an indication that the results are not very convincing. a wide range of antibiotics is urgently needed for patients with drug reaction or resistance problems. the anti-toxoplasmic activity of water and ethanol extracts as well as the oil of some home spices ( ...200923012192
indigenous drugs in ischemic heart disease in patients with diabetes.india is currently facing the silent epidemic of ischemic heart disease, type 2 diabetes mellitus (t2dm), hypertension, and stroke. both diabetes and ischemic heart disease appear in indian people a decade earlier compared to whites. the recent evidence that certain medicinal plants possess hypoglycemic, lipid-lowering, and immunomodulating properties on account of their rich flavonoid and/or other glucose-lowering active constituents merits scientific scrutiny in this regard.200919922253
formulation development and in vitro antioxidant studies of churnas containing natural sweetener and nutraceutical.gymnema sylvestre, curcuma longa, azadiracta indica, aegle marmelos, salacia chinensis, emblica officinalis were used as active components and stevia rebaudiana as natural sweetener with nutraceuticalfor development of churnas. the free radical scavengingpotential of churnas was studied by using different antioxidant models of screening. the hydroalcoholic extract of sweet and bitter churnas at 500μg/ ml showed maximum scavenging of the riboflavin net system, dpph and total antioxidant capacity. ...200922557329
an ulcer negative for helicobacter pylori and nonsteroidal anti-inflammatory drugs? consider herbal treatment as the culprit!the cause of peptic ulcers that are negative for helicobacter pylori or nonsteroidal anti-inflammatory drug/aspirin use is an area of immense interest. we report here, for the first time, a case report of a young female who developed reflux-like symptoms and multiple ulcers as a result of herbal treatment with turmeric for osteoarthritis. with the current marked increase in usage of herbal products as part of a complementary medicine approach, gastroenterologists must be vigilant when evaluating ...200926192422
apoptotic effects of curcumin on human osteosarcoma u2os cells.curcumin, an active ingredient derived from the rhizome of the plant, curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. the aims of this study were to examine whether curcumin can induce apoptosis in an osteosarcoma cell line.200922009832
antimicrobial activity of curcumin against helicobacter pylori isolates from india and during infections in mice.treatment failure is a major cause of concern for the helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. curcumin, diferuloylmethane from turmeric, has recently been shown to arrest h. pylori growth. the antibacterial activity of curcumin against 65 clinical isolates of h. pylori in vitro and during protection against h. pylori infection in vivo was examined. the mic of curcumin ranges from 5 microg/ml to 50 microg/ml, showing its effectiveness ...200919204190
antioxidant efficacy of curcuminoids from turmeric ( curcuma longa l.) powder in broiler chickens fed diets containing aflatoxin b1.a 3-week-feeding study (1-21 d post-hatch) was conducted to evaluate the efficacy of total curcuminoids (tcmn), as an antioxidant, to ameliorate the adverse effects of aflatoxin b1 (afb1) in broiler chickens. turmeric powder (curcuma longa l.) that contained 2.55 % tcmn was used as a source of tcmn. six cage replicates of five chicks each were assigned to each of six dietary treatments, which included: basal diet; basal diet supplemented with 444 mg/kg tcmn; basal diet supplemented with 1.0 mg/k ...200919682401
turmeric reduces inflammatory cells in hamster opisthorchiasis.the curcumin compound from turmeric is effective in the treatment of many inflammatory diseases. the aim of our present study was to evaluate the efficacy of turmeric on reducing the histopathological changes of hamster opisthorchiasis. hamsters were infected with opisthorchis viverrini and then administered turmeric. using light microscopic observation, liver function tests for alanine transaminase (alt), alkaline phosphatase, and direct bilirubin were investigated. the resulting histopathologi ...200919633869
curcumin inhibits acth- and angiotensin ii-stimulated cortisol secretion and ca(v)3.2 current.adrenocorticotropic hormone and angiotensin ii stimulate cortisol secretion from bovine adrenal zona fasciculata cells by the activation of adenylate cyclase and phospholipase c-coupled receptors. curcumin (1- 20 mum), a compound found in the spice turmeric, inhibited cortisol secretion stimulated by acth, angii, and 8cpt-camp. curcumin also suppressed acth-stimulated increases in mrnas coding for steroid acute regulatory protein and cyp11a1 steroid hydroxylase. in whole cell patch clamp recordi ...200919653644
curcumin enhances paraquat-induced apoptosis of n27 mesencephalic cells via the generation of reactive oxygen species.curcumin, the active compound of the rhizome of curcuma longa has anti-inflammatory, antioxidant and antiproliferative activities. this agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. while curcumin has been identified as an activator of apoptosis in several cell lines, the mechanism by which it initiates apoptosis, however, remains poorly understood. we considered cur ...200919660496
curcumin inhibits proliferation of colorectal carcinoma by modulating akt/mtor signaling.curcumin, a natural polyphenol product of the plant curcuma longa, has been shown to inhibit the growth and progression of colorectal cancer; however, the anticancer mechanism of curcumin remains to be elucidated.200919661333
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