Publications

interaction of host cellular factor anp32b with matrix proteins of different paramyxoviruses.	although most non-segmented negative-strand rna viruses (nnsvs) replicate in the cytoplasm, nnsv proteins often exert host manipulatory functions in the nucleus. matrix (m) proteins of henipaviruses and other paramyxoviruses shuttle through the nucleus, where host factors may bind for m modification or host-cell manipulation. acidic leucine-rich nuclear phosphoprotein 32 family member b (anp32b) is an interactor of hendra and nipah virus m. both accumulate in the nucleus in an anp32b-dependent m ...	2020	31793855
identifying potential entry inhibitors for emerging nipah virus by molecular docking and chemical-protein interaction network.	nipah virus (niv) is a newly emergent paramyxovirus that has caused various outbreaks in asian countries. despite its acute pathogenicity and lack of approved therapeutics for human use, there is an urgent need to determine inhibitors against niv. hence, this work includes prospection of potential entry inhibitors by implementing an integrative structure- and network-based drug discovery approach. fda-approved drugs were screened against attachment glycoprotein (niv-g, pdb: 2vsm), one of the pri ...	2020	31771426
structural insight into paramyxovirus and pneumovirus entry inhibition.	paramyxoviruses and pneumoviruses infect cells through fusion (f) protein-mediated merger of the viral envelope with target membranes. members of these families include a range of major human and animal pathogens, such as respiratory syncytial virus (rsv), measles virus (mev), human parainfluenza viruses (hpivs), and highly pathogenic nipah virus (niv). high-resolution f protein structures in both the metastable pre- and the postfusion conformation have been solved for several members of the fam ...	2020	32245118
correction for satterfield et al., "nipah virus c and w proteins contribute to respiratory disease in ferrets".		2020	32234799
nipah@20: lessons learned from another virus with pandemic potential.	nipah disease is listed as one of the who priority diseases that pose the greatest public health risk due to their epidemic potential. more than 200 experts from around the world convened in singapore last year to mark the 20th anniversary of the first nipah virus outbreaks in malaysia and singapore. most of these experts are now involved in responding to the coronavirus disease 2019 (covid-19) pandemic. here, members of the organizing committee of the 2019 nipah virus international conference r ...	2020	32641430
changing contact patterns over disease progression: nipah virus as a case study.	contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. we used surveys among 1642 contacts of 94 nipah virus case patients in bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. the number of contacts increased with severity and, for case patients who died, peaked on the day of ...	2020	32115627
potential novel inhibitors against emerging zoonotic pathogen nipah virus: a virtual screening and molecular dynamics approach.	nipah virus is a pathogen considered highly infectious, and its lethality can cause between 40% and 70% of deaths in those infected. at present, no effective treatment is available which results in an imperative need to explore new approaches to the search for drugs. through virtual screening techniques, docking and molecular dynamics, 183 ligands were evaluated against the nipah virus glycoprotein (niv-g), involved throughout the process of virus entry to the host cell, resulting in a good targ ...	2020	31411538
nipah virus: a review on epidemiological characteristics and outbreaks to inform public health decision making.	the objectives of this review were to understand the epidemiology and outbreak of niv infection and to discuss the preventive and control measures across different regions. we searched pubmed and scopus for relevant articles from january 1999 to july 2018 and identified 927 articles which were screened for titles, abstracts and full texts by two review authors independently. the screening process resulted in 44 articles which were used to extract relevant information. information on epidemiology ...	2020	30808593