Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| bacterial cell-envelope glycoconjugates. | prokaryotic glycosylation fulfills an important role in maintaining and protecting the structural integrity and function of the bacterial cell wall, as well as serving as a flexible adaption mechanism to evade environmental and host-induced pressure. the scope of bacterial and archaeal protein glycosylation has considerably expanded over the past decade(s), with numerous examples covering the glycosylation of flagella, pili, glycosylated enzymes, as well as surface-layer proteins. this article a ... | 2013 | 24274370 |
| suppuration-associated bacteria in patients with chronic and aggressive periodontitis. | suppuration (sup) on probing may be an indication of active periodontal breakdown. the aim of the present study is to analyze which subgingival species are associated with sup in patients with chronic (cp) and aggressive (agp) periodontitis. | 2013 | 23327648 |
| porphyromonas gingivalis and treponema denticola synergistic polymicrobial biofilm development. | chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. porphyromonas gingivalis, treponema denticola and tannerella forsythia have all been implicated as playing roles in disease progression. p. gingivalis cell-surface-located protease/adhesins, the gingipains, have been suggested to be involved in its interactions with several other bacterial species. the aims of this study were t ... | 2013 | 23990979 |
| interleukin-8 responses of multi-layer gingival epithelia to subgingival biofilms: role of the "red complex" species. | periodontitis is an infectious inflammatory disease that results in the destruction of the tooth-supporting (periodontal) tissues. the gram-negative anaerobic species porphyromonas gingivalis, tannerella forsythia and treponema denticola, (also known as the "red complex" species) are highly associated with subgingival biofilms at periodontitis-affected sites. a major chemokine produced by the gingival epithelium in response to biofilm challenge, is interleukin (il)-8. the aim of this in vitro st ... | 2013 | 24339946 |
| impact of early colonizers on in vitro subgingival biofilm formation. | the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ... | 2013 | 24340084 |
| characterizing the s-layer structure and anti-s-layer antibody recognition on intact tannerella forsythia cells by scanning probe microscopy and small angle x-ray scattering. | tannerella forsythia is among the most potent triggers of periodontal diseases, and approaches to understand underlying mechanisms are currently intensively pursued. a ~22-nm-thick, 2d crystalline surface (s-) layer that completely covers tannerella forsythia cells is crucially involved in the bacterium-host cross-talk. the s-layer is composed of two intercalating glycoproteins (tfsa-gp, tfsb-gp) that are aligned into a periodic lattice. to characterize this unique s-layer structure at the nanom ... | 2013 | 24089361 |
| prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery. | the objective of the present study was to detect the presence of specific periodontopathogenic bacteria in the coronary plaque of patients with coronary artery disease and to find out the significant association between the periodontal status and the presence of pathogenic bacteria in the coronary plaque. | 2013 | 24554879 |
| protein-linked glycans in periodontal bacteria: prevalence and role at the immune interface. | protein modification with complex glycans is increasingly being recognized in many pathogenic and non-pathogenic bacteria, and is now thought to be central to the successful life-style of those species in their respective hosts. this review aims to convey current knowledge on the extent of protein glycosylation in periodontal pathogenic bacteria and its role in the modulation of the host immune responses. the available data show that surface glycans of periodontal bacteria orchestrate dendritic ... | 2013 | 24146665 |
| determination of periodontopathogens in patients with cri du chat syndrome. | cri du chat syndrome is a genetic alteration associated with some oral pathologies. however, it has not been described previously any clinical relationship between the periodontal disease and the syndrome. the purpose of this comparative study was to compare periodontopathogenic flora in a group with cri du chat syndrome and another without the síndrome, to assess a potential microbiological predisposition to suffer a periodontitis. | 2013 | 24121919 |
| microbial changes in subgingival plaque and polymicrobial intracellular flora in buccal cells after fixed orthodontic appliance therapy: a preliminary study. | the oral ecosystem is strictly related to a balance maintained by specific niches recognized as sites, where oral bacteria can metabolize avoiding the immune system response. the oral bacteria species that colonize the ecological niches vary during fixed orthodontic treatment, with a prevalence of periodontal bacterial species. qualitative analysis of five periodontal pathogens was used to investigate the microbial colonization rate in the crevice and buccal epithelial cells. the presence of ina ... | 2013 | 24223591 |
| quantitative analysis of periodontal pathogens present in the saliva of geriatric subjects. | at present, information regarding periodontal disease in geriatric patients is scarce. the purpose of this study was to quantify the periodontal pathogens present in the saliva of korean geriatric patients and assess the relationship between the bacterial levels and the periodontal condition. | 2013 | 24040571 |
| multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. | to follow changes (over 2 years) in subgingival bacterial counts of five microbial complexes including health-related actinomyces spp. in deeper pockets (≥5 mm) after periodontal treatments. | 2013 | 23853701 |
| association between periodontal disease and plasma levels of cholesterol and triglycerides. | untreated periodontal disease seems to cause low grade systemic inflammation and blood lipid alteration leading to increased cardiovascular disease risk. to start testing this hypothesis in colombian patients, a multicentre study was conducted including the three main state capitals: bogota, medellin and cali. | 2013 | 24892452 |
| oral microflora and periodontal disease: new technology for diagnosis in dentistry. | periodontitis is a disease that affects and destroys the tissues that support teeth. tissues damage results from a prolonged inflammatory response to an ecological shift in the composition of subgingival biofilms. three bacterial species that constitute the red complex group, porphyromonas gingivalis, tannerella forsythia, and treponema denticola, are considered the main pathogens involved in periodontitis. in the present study a real-time pcr based assay was designed to detect and quantify red ... | 2013 | 23991267 |
| periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis. | oral lichen planus (olp) is a chronic inflammatory disease that is frequently detected in oral tissues. the aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia and treponema denticola in olp patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-olp patients. our study included 27 (18 chronic ... | 2013 | 23743616 |
| structure and immunogenicity of the rough-type lipopolysaccharide from the periodontal pathogen tannerella forsythia. | tannerella forsythia is a gram-negative anaerobic organism that inhabits subgingival plaque biofilms and is covered with a so far unique surface layer composed of two glycoproteins. it belongs to the so-called "red complex" of bacteria comprising species that are associated with periodontal disease. while the surface layer glycoprotein glycan structure had been elucidated recently and found to be a virulence factor, no structural data on the lipopolysaccharide (lps) of this organism were availab ... | 2013 | 23616409 |
| gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen porphyromonas gingivalis during invasion. | porphyromonas gingivalis and tannerella forsythia are gram-negative pathogens strongly associated with periodontitis. their abilities to interact, invade and persist within host cells are considered crucial to their pathogenicity, but the mechanisms by which they subvert host defences are not well understood. in this study, we set out to investigate whether p. gingivalis and t. forsythia directly target key signalling molecules that may modulate the host cell phenotype to favour invasion and per ... | 2013 | 23714361 |
| effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. i. overall effect and kinetics of change. | to examine the 2-year post-therapy kinetics of change in the composition of subgingival biofilms. | 2013 | 23710672 |
| structure of the catalytic domain of the tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor. | karilysin is the only metallopeptidase identified as a virulence factor in the odontopathogen tannerella forsythia owing to its deleterious effect on the host immune response during bacterial infection. the very close structural and sequence-based similarity of its catalytic domain (kly18) to matrix metalloproteinases suggests that karilysin was acquired by horizontal gene transfer from an animal host. previous studies by phage display identified peptides with the consensus sequence xwfpxxxggg ( ... | 2013 | 23695557 |
| the surface layer of tannerella forsythia contributes to serum resistance and oral bacterial coaggregation. | tannerella forsythia is an anaerobic, gram-negative bacterium involved in the so-called "red complex," which is associated with severe and chronic periodontitis. the surface layer (s-layer) of t. forsythia is composed of cell surface glycoproteins, such as tfsa and tfsb, and is known to play a role in adhesion/invasion and suppression of proinflammatory cytokine expression. here we investigated the association of this s-layer with serum resistance and coaggregation with other oral bacteria. the ... | 2013 | 23357386 |
| mixed red-complex bacterial infection in periodontitis. | the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia (formerly bacteroides forsythus), are recognized as the most important pathogens in adult periodontal disease. these bacteria are usually found together in periodontal pockets, suggesting that they may cause destruction of the periodontal tissue in a cooperative manner. this article discusses the interspecies pathogenic interactions within the red complex. | 2013 | 23533413 |
| polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic apoe(null) mice. | periodontal disease (pd) and atherosclerosis are both polymicrobial and multifactorial and although observational studies supported the association, the causative relationship between these two diseases is not yet established. polymicrobial infection-induced periodontal disease is postulated to accelerate atherosclerotic plaque growth by enhancing atherosclerotic risk factors of orally infected apolipoprotein e deficient (apoe(null)) mice. at 16 weeks of infection, samples of blood, mandible, ma ... | 2013 | 23451182 |
| molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis. | the human palatine tonsils, which belong to the central antigen handling sites of the mucosal immune system, are frequently affected by acute and recurrent infections. this study compared the microbiota of the tonsillar crypts in children and adults affected by recurrent tonsillitis with that of healthy adults and children with tonsillar hyperplasia. an in-depth 16s rrna gene based pyrosequencing approach combined with a novel strategy that included phylogenetic analysis and detection of species ... | 2013 | 23437130 |
| association between selected oral pathogens and gastric precancerous lesions. | we examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. a total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. an oral examination was performed to measure periodontal indices. plaque and saliva samples were tested with real-time quantitative pcr for dna levels of pathogens related to periodontal disease (porphyromonas gingivalis, tannerel ... | 2013 | 23308100 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| association between immunoglobulin g1 against tannerella forsythia and reduction in the loss of attachment tissue. | to evaluate whether the levels of immunoglobulin g (igg) antibody to tanerella forsythia are associated with periodontal status. | 2014 | 25568807 |
| serum igg antibody levels to periodontal microbiota are associated with incident alzheimer disease. | periodontitis and alzheimer disease (ad) are associated with systemic inflammation. this research studied serum igg to periodontal microbiota as possible predictors of incident ad. | 2014 | 25522313 |
| shifts in campylobacter species abundance may reflect general microbial community shifts in periodontitis progression. | oral campylobacter species have been found to be associated with periodontitis progression. while the etiological significance of campylobacter rectus is quite established, the association of c. gracilis, c. concisus, and c. curvus with health or disease remains contradictory. | 2014 | 25412608 |
| miropin, a novel bacterial serpin from the periodontopathogen tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. | all prokaryotic genes encoding putative serpins identified to date are found in environmental and commensal microorganisms, and only very few prokaryotic serpins have been investigated from a mechanistic standpoint. herein, we characterized a novel serpin (miropin) from the human pathogen tannerella forsythia, a bacterium implicated in initiation and progression of human periodontitis. in contrast to other serpins, miropin efficiently inhibited a broad range of proteases (neutrophil and pancreat ... | 2014 | 25389290 |
| investigate the correlation between clinical sign and symptoms and the presence of p. gingivalis, t. denticola, and t. forsythia individually or as a "red complex" by a multiplex pcr method. | the aim of this study was to investigate the correlation between endodontic clinical signs and symptoms and the presence of porphyromonas gingivalis, treponema denticola, and tannerella forsythia or their association by multiplex polymerase chain reaction assay. | 2014 | 25506144 |
| a pathogenic trace of tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin. | tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. however, its virulence factors, including numerous putative proteases, are mostly uncharacterized. karilysin is a newly described matrix metalloprotease-like enzyme of t. forsythia. since pathogen-derived proteases may affect the host defense system via modulation of the cytokine network, the aim of this study was to determine the influence of karilysin on tumor necrosis factor-α (tnf-α). the results s ... | 2014 | 25175980 |
| role of porphyromonas gingivalis gingipains in multi-species biofilm formation. | periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic inflammatory reactions by the affected tissue. the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola are commonly found as part of the microbiota of subgingival biofilms, and they are associated with the occurren ... | 2014 | 25270662 |
| lack of a surface layer in tannerella forsythia mutants deficient in the type ix secretion system. | tannerella forsythia, a gram-negative anaerobic bacterium, is an important pathogen in periodontal disease. this bacterium possesses genes encoding all known components of the type ix secretion system (t9ss). t. forsythia mutants deficient in genes orthologous to the t9ss-encoding genes pork, port and sov were constructed. all pork, port and sov single mutants lacked the surface layer (s-layer) and expressed less-glycosylated versions of the s-layer glycoproteins tfsa and tfsb. in addition, thes ... | 2014 | 25023245 |
| microbial signature profiles of periodontally healthy and diseased patients. | to determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. | 2014 | 25139407 |
| association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. | polycystic ovary syndrome (pcos) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. this study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevated in pcos, compared to systemic health. a total of 125 women were included in four groups; 45 women with pcos and healthy periodontium, 35 women with pcos and gingivitis, 25 syste ... | 2014 | 25232962 |
| expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. | periodontitis is an inflammatory infectious disease that destroys the tooth-supporting tissues. it is caused by multi-species subgingival biofilms that colonize the tooth surface. porphyromonas gingivalis, treponema denticola and tannerella forsythia (i.e. 'red complex' bacteria) are characteristic subgingival biofilm species. the triggering receptor expressed on myeloid cells 1 (trem-1) is a cell surface receptor of the immunoglobulin superfamily, with a role in the amplification of proinflamma ... | 2014 | 24924298 |
| the presence of cariogenic and periodontal pathogens in the oral cavity of one-year-old infants delivered pre-term with very low birthweights: a case control study. | recently, the dental literature has focused mainly on the microbial colonization of healthy full-term infants and their mothers or caretakers. however, oral microbial acquisition by premature infants has not been adequately investigated, and the correlation between pre-term birth and the presence of cariogenic and periodontal pathogens has not been determined. the aim of this study was to identify the presence and quantities of representative cariogenic and periodontal pathogens in the oral cavi ... | 2014 | 25178742 |
| life in a diverse oral community - strategies for oxidative stress survival. | while the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. bacterial species including porphyromonas gingivalis, treponema denticola and tannerella forsythia, a consortium previously designated as the "red complex" is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. | 2014 | 26744578 |
| identification of microbial pathogens in periodontal disease and diabetic patients of south indian population. | periodontitis have been referred to as the sixth complication of diabetes found in high prevalence among diabetic patients than among healthy controls. the aim of the present study was to examine the periodontal disease status among collected dental plaque samples. chromosomal dna was isolated and amplified by universal primers. the dna was sequenced for bacterial confirmation and phylogenetic analysis performed for the evolutionary relationship with other known pathogens. no amplification produ ... | 2014 | 24966528 |
| porphyromonas gingivalis: major periodontopathic pathogen overview. | porphyromonas gingivalis is a gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. this anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. the purpose of this review is to provide an overview ... | 2014 | 24741603 |
| bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis. | periodontal diseases are multifactorial, caused by polymicrobial subgingival pathogens, including porphyromonas gingivalis, treponema denticola, and tannerella forsythia. chronic periodontal infection results in inflammation, destruction of connective tissues, periodontal ligament, and alveolar bone resorption, and ultimately tooth loss. enoxacin and a bisphosphonate derivative of enoxacin (bis-enoxacin) inhibit osteoclast formation and bone resorption and also contain antibiotic properties. our ... | 2014 | 24638087 |
| the influence of orthodontic fixed appliances on the oral microbiota: a systematic review. | to investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. | 2014 | 24945514 |
| pathogens and host immunity in the ancient human oral cavity. | calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. we report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. we characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ... | 2014 | 24562188 |
| single cell genomics of uncultured, health-associated tannerella bu063 (oral taxon 286) and comparison to the closely related pathogen tannerella forsythia. | the uncultivated bacterium tannerella bu063 (oral taxon 286) is the closest relative to the periodontal pathogen tannerella forsythia, but is not disease-associated itself. using a single cell genomics approach, we isolated 12 individual bu063 cells by flow cytometry, and we amplified and sequenced their genomes. comparative analyses of the assembled genomic scaffolds and their gene contents allowed us to study the diversity of this taxon within the oral community of a single human donor that pr ... | 2014 | 24551246 |
| transcriptional responses of treponema denticola to other oral bacterial species. | the classic organization by socransky and coworkers categorized the oral bacteria of the subgingival plaque into different complexes. treponema denticola, porphyromonas gingivalis and tannerella forsythia are grouped into the red complex that is highly correlated with periodontal disease. socransky's work closely associates red with orange complex species such as fusobacterium nucleatum and prevotella intermedia but not with members of the other complexes. while the relationship between species ... | 2014 | 24505483 |
| in vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts. | findings from animal and human studies have indicated that an oily calcium hydroxide suspension (ochs) may improve early wound healing in the treatment of periodontitis. calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of ochs on the influence of periodontal wound healing/regeneration is still very limited. the purpose of this in vitro study was to investigate the effect of ochs on periodontopathogenic bacteria as well as on the ... | 2014 | 24475753 |
| clinical evaluation of salivary periodontal pathogen levels by real-time polymerase chain reaction in patients before dental implant treatment. | periodontal pathogens in dental plaque are the main causative agents of periodontitis and peri-implantitis. detection of the presence of such periodontal pathogens early would serve as a useful tool in the diagnosis and treatment of this disease. therefore, the purpose of this study was to investigate whether the periodontal pathogen levels in saliva were correlated with the periodontal status of patients receiving implant treatment. | 2014 | 23745964 |
| oxantel disrupts polymicrobial biofilm development of periodontal pathogens. | bacterial pathogens commonly associated with chronic periodontitis are the spirochete treponema denticola and the gram-negative, proteolytic species porphyromonas gingivalis and tannerella forsythia. these species rely on complex anaerobic respiration of amino acids, and the anthelmintic drug oxantel has been shown to inhibit fumarate reductase (frd) activity in some pathogenic bacteria and inhibit p. gingivalis homotypic biofilm formation. here, we demonstrate that oxantel inhibited p. gingival ... | 2014 | 24165189 |
| neutrophil mobilization by surface-glycan altered th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss. | alveolar bone (tooth-supporting bone) erosion is a hallmark of periodontitis, an inflammatory disease that often leads to tooth loss. periodontitis is caused by a select group of pathogens that form biofilms in subgingival crevices between the gums and teeth. it is well-recognized that the periodontal pathogen porphyromonas gingivalis in these biofilms is responsible for modeling a microbial dysbiotic state, which then initiates an inflammatory response destructive to the periodontal tissues and ... | 2014 | 25225799 |
| 16s rdna-based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are leading causes of mortality in hospital intensive care units. we sought to determine whether dental plaque biofilms might harbor pathogenic bacteria that can eventually cause lung infections in patients with severe ae-copd. | 2014 | 24484531 |
| the association between detectable plasmatic human immunodeficiency virus (hiv) viral load and different subgingival microorganisms in brazilian adults with hiv: a multilevel analysis. | this study investigates the association between detectable plasmatic human immunodeficiency virus (hiv) viral load (hvl) and high levels of periodontal- and non-periodontal-related microorganisms in the subgingival microbiota of individuals with hiv. | 2014 | 23952074 |
| the effects of different orthodontic appliances upon microbial communities. | orthodontic appliances can promote accumulation of dental plaque, with associated enamel decalcification or gingival inflammation. the aim of this study was to examine longer-term microbiological changes during orthodontic treatment with fixed appliances. | 2014 | 24345204 |
| colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria. | biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola). | 2014 | 24949828 |
| microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. | the detection of special bacterial species in patients with periodontitis is considered to be useful for clinical diagnosis and treatment. the collection of subgingival plaque samples is the common way for the determination of periodontopathic bacteria. however, recently, salivary analysis has been discussed as an advantageous future diagnostic method for periodontitis because it offers simple quantitative sampling and the possibility to assess various bacteria. the aim of this cross-sectional s ... | 2014 | 24144271 |
| comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease. | polymicrobial diseases are caused by combinations of multiple bacteria, which can lead to not only mild but also life-threatening illnesses. periodontitis represents a polymicrobial disease; porphyromonas gingivalis, treponema denticola and tannerella forsythia, called 'the red complex', have been recognized as the causative agents of periodontitis. although molecular interactions among the three species could be responsible for progression of periodontitis, the relevant genetic mechanisms are u ... | 2014 | 25171331 |
| the effect of il-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls. | chronic periodontitis (cp) is an inflammatory disease of the teeth-supporting tissues in which genetic predisposition, dental plaque bacteria, and immune mechanisms all play important roles. the aim of this study was to evaluate the occurrence of il-4 gene polymorphisms in chronic periodontitis and to investigate the association between polymorphisms and cytokines production after bacterial stimulation. sixty-two subjects (47 cp patients and 15 healthy controls) with detected two polymorphisms i ... | 2014 | 25530681 |
| microbiological effects of periodontal therapy plus azithromycin in patients with diabetes: results from a randomized clinical trial. | current evidence suggests that periodontal infection may aggravate diabetes control. the aim of this study was to determine the changes in the frequency with which porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans were detected in patients with diabetes with the use of non-surgical therapy plus azithromycin in a randomized clinical trial. one hundred and five (105) patients with diabetes and chronic periodontitis were randomly assigned ... | 2014 | 25523961 |
| detection of periodontal pathogens in the patients with aortic aneurysm. | the occurrence and development of aortic aneurysm (aa) are associated with infection. some researchers have detected the dna of periodontal pathogens in aa samples in certain populations. however, it has not been done in chinese population. the objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of aa patients. | 2014 | 25430459 |
| prevalence of six periodontal pathogens in subgingival samples of italian patients with chronic periodontitis. | the aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 italian patients with chronic periodontitis. possible correlations with clinical parameters, age, gender and smoking status were also investigated. at first visit a pooled subgingival plaque sample was obtained for each subject by using the paper-point method. the samples were processed and analysed according to a commercially available quantitative real time polymerase chain reaction assay (m ... | 2014 | 25387289 |
| evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients. | to evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. | 2014 | 25316464 |
| antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden. | previous studies have suggested positive associations between periodontal infection and cardiovascular disease. we aimed to investigate the associations of circulating antibodies against periodontal pathogens with 1-year cardiovascular outcome, as well as the extent of coronary atherosclerosis, plaque vulnerability and lesion remodeling on intravascular ultrasound (ivus) imaging. | 2014 | 25233105 |
| igg sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites. | to evaluate the association among serum immunoglobulin g (igg) responses to aggregatibacter actinomycetemcomitans (aa) serotypes a, b and c, porphyromonas gingivalis (pg), tannerella forsythia (tf) and clinical parameters in aggressive periodontitis (ap) subjects. associations between periodontal pathogens and clinical and immunological parameters were also evaluated. | 2014 | 25070874 |
| antibacterial activities of extracts from ugandan medicinal plants used for oral care. | medicinal plants are widely used for treatment of oral/dental diseases in uganda. | 2014 | 24945400 |
| periodontal pathogens in atheromatous plaque. | there has been increasing attention paid in recent years to the possibility that oral bacterial infection, particularly periodontal disease may influence the initiation and or progression of systemic diseases. these studies confirm the observation that heart disease is the most commonly found systemic condition in patients with periodontal disease. moreover, the literature has also highlighted substantial evidence indicating the presence of gram-negative periodontal pathogens in atheromatous pla ... | 2014 | 24943760 |
| clinical and microbiological characterization of localized aggressive periodontitis: a cohort study. | localized aggressive periodontitis (lagp) is an infectious periodontal disease which generally affects young people. recent data suggest the involvement of different bacterial species in different populations. the causative bacterial species in israel has never been identified despite a high prevalence of lagp in this population. the objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an israeli lagp population who were also clinically assessed. | 2014 | 24861390 |
| evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time pcr. | the aim of this study was to investigate the mandibular third molar pericoronitis flora by using real-time polymerase chain reaction (pcr). | 2014 | 24835305 |
| periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy. | to assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (agp) after active periodontal therapy (apt) and further influencing factors. | 2014 | 24708362 |
| [clinical and microbiological effects of the initial periodontal therapy]. | periodontitis is a destructive inflammatory disease of the tooth-supporting tissues, primarily caused by gram-negative microorganisms. thus, the primary objective of cause-related initial periodontal therapy is disruption and removal of the subgingival biofilm. | 2014 | 24684025 |
| isolation of treponema and tannerella spp. from equine odontoclastic tooth resorption and hypercementosis related periodontal disease. | red complex bacteria, i.e. porphyromonas gingivalis, treponema denticola and tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. periodontal disease is also encountered in horses, with equine odontoclastic tooth resorption and hypercementosis (eotrh) constituting a particular form of disease. however, only little is known about the oral microbiome of healthy and periodontitis-affected equids. | 2014 | 23742079 |
| oral inflammation, tooth loss, risk factors, and association with progression of alzheimer's disease. | periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals. periodontal pathogens porphyromonas gingivalis, tannerella forsythia, and treponema denticola are implicated in the development of a number of inflammatory pathologies at remote organ sites, including alzheimer's disease (ad). the initial inflammatory hypothesis proposed that ad hallmark proteins were the ... | 2014 | 24946875 |
| periodontal disease associated with red complex bacteria in dogs. | red complex bacteria (treponema denticola, tannerella forsythia and porphyromonas gingivalis) play a major role in the aetiology of periodontal disease in humans. this study was designed to evaluate the association of such bacteria with periodontal disease in dogs. | 2014 | 24450418 |
| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25507669 |
| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25434071 |
| [comparison of the effects of ginkgo biloba extract and minocycline hydrochlovide on periodontitis]. | to compare the clinical effect of ginkgo biloba extract gel (ginkgo biloba extract,egb) and minocycline hydrochloride (periocline) on periodontitis and their inhibition on putative periodontal pathogens. | 2014 | 25199931 |
| periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation. | epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. several human studies have detected bacterial dna corresponding to periodontal pathogens in cardiovascular samples. intraplaque hemorrhage has been associated with a higher risk of atherosclerotic plaque rupture, potentially mediated by neutrophil activation. in this study, we hypothesized that plaque composition may be related to periodontal pathogens. | 2014 | 25173070 |
| dentilisin involvement in coaggregation between treponema denticola and tannerella forsythia. | periodontitis arises from a biofilm consisting of gram-negative anaerobic rods and spirochetes. porphyromonas gingivalis, treponema denticola, and tannerella forsythia, termed the red complex, have been co-isolated with high frequency from chronic periodontitis lesions, and these microorganisms are thought to be major pathogens of the disease. coaggregation is an important strategy in the colonization of dental plaque biofilm by these bacteria. in the present study, we investigated the coaggrega ... | 2014 | 25152229 |
| progression of periodontal inflammation in adolescents is associated with increased number of porphyromonas gingivalis, prevotella intermedia, tannerella forsythensis, and fusobacterium nucleatum. | the study aims to evaluate the change of related subgingival periodontopathogens among different stage of gingivitis in adolescent and assess the relationship between periodontopathogens and the progression of periodontal inflammation. | 2014 | 24025042 |
| bacteria community study of combined periodontal-endodontic lesions using denaturing gradient gel electrophoresis and sequencing analysis. | the entire microbial population and predominant microflora of root canals (rcs) and adjacent periodontal pockets (pps) from teeth with combined periodontal-endodontic lesions were determined and compared. | 2014 | 24579762 |
| biology and pathogenesis of cytomegalovirus in periodontal disease. | human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. porphyromonas gingivalis, tannerella forsythia, aggregatibacter actinomycetemcomitans, treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features of the disease. cytomegalovirus infects periodontal macrophages an ... | 2014 | 24320955 |
| reducing the bioactivity of tannerella forsythia lipopolysaccharide by porphyromonas gingivalis. | tannerella forsythia is considered a pathogen of periodontitis and forms a biofilm with multi-species bacteria in oral cavity. lipopolysaccharide is a powerful immunostimulator and induces inflammation and shock. the purpose of this study was to investigate the characteristics of t. forsythia lps in its co-cultivation with fusobacterium nucleatum or porphyromonas gingivalis. t. forsythia was co-cultured in the presence and absence of f. nucleatum and p. gingivalis and then t. forsythia lps was e ... | 2014 | 25098564 |
| structural and functional characterization of nanu, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling bacteroidetes species. | many human-dwelling bacteria acquire sialic acid for growth or surface display. we identified previously a sialic acid utilization operon in tannerella forsythia that includes a novel outer membrane sialic acid-transport system (nanou), where nano (neuraminate outer membrane permease) is a putative tonb-dependent receptor and nanu (extracellular neuraminate uptake protein) is a predicted susd family protein. using heterologous complementation of nanou genes into an escherichia coli strain devoid ... | 2014 | 24351045 |
| inter-bacterial correlations in subgingival biofilms: a large-scale survey. | although the complexity of the oral ecology and the ecological differences between health and disease are well accepted, a clear view on the dynamics in relation to disease is lacking. in this study, the prevalence and abundance of 20 key oral bacteria was assessed in health and disease and more importantly a closer look was given to the inter-bacterial relationships. | 2014 | 24102517 |
| cluster of bacteria associated with peri-implantitis. | information on the microbiota in peri-implantitis is limited. we hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. | 2014 | 23527870 |
| soluble triggering receptor expressed on myeloid cells 1 (strem-1) in gingival crevicular fluid: association with clinical and microbiologic parameters. | soluble triggering receptor expressed on myeloid cells 1 (strem-1) belongs to the immunoglobulin superfamily and is involved in amplification of the inflammatory response to bacterial infection. this cross-sectional study aims to investigate the levels of strem-1 in gingival crevicular fluid (gcf) of individuals without periodontitis and with chronic periodontitis (cp) or generalized aggressive periodontitis (gagp) and their association with the levels of key periodontal pathogens in subgingival ... | 2014 | 23659423 |
| salivary carriage of periodontal pathogens in generalized aggressive periodontitis families. | generalized aggressive periodontitis (gap) is a multifactorial disease that shows a specific microbial profile and a familial aggregation. | 2014 | 23647376 |
| detection of eight periodontal microorganisms and distribution of porphyromonas gingivalis fima genotypes in chinese patients with aggressive periodontitis. | the microbiologic feature of aggressive periodontitis (agp) in chinese patients has not yet been determined. this study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the porphyromonas gingivalis fima genotype in a cohort of chinese patients with agp. | 2014 | 23646850 |
| molecular microbiological evaluation of subgingival biofilm sampling by paper point and curette. | the present clinical study aimed to investigate if there are differences in microbiological outcomes dependent on the subgingival biofilm collection method. subgingival biofilm samples were collected from the four deepest pockets (>5 mm) of 17 patients with aggressive periodontitis (agp) and 33 patients with chronic periodontitis (cp), first by paper point and thereafter by curette. samples obtained with the same method were pooled together from each patient and forwarded for molecular microbiol ... | 2014 | 23879704 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| in vivo effectiveness of silicone gel sheets as barriers at the inner microgap between a prosthetic abutment and an external-hexagon implant platform. | bacterial penetration and colonization of the microgap at the implant-abutment interface have been reported in several studies. the aim of this study was to evaluate the effectiveness of placing a silicone membrane between the abutment and the implant platform in an attempt to seal the interface. | 2014 | 24451862 |
| detection and quantification of periodontal pathogens in smokers and never-smokers with chronic periodontitis by real-time polymerase chain reaction. | the purpose of the present investigation is to compare the presence and number of periodontal pathogens in the subgingival microbiota of smokers versus never-smokers with chronic periodontitis and matched probing depths (pds) using real-time polymerase chain reaction (rt-pcr). | 2014 | 24794687 |
| genetic characteristics and pathogenic mechanisms of periodontal pathogens. | periodontal disease is caused by a group of bacteria that utilize a variety of strategies and molecular mechanisms to evade or overcome host defenses. recent research has uncovered new evidence illuminating interesting aspects of the virulence of these bacteria and their genomic variability. this paper summarizes some of the strategies utilized by the major species - aggregatibacter actinomycetemcomitans, tannerella forsythia, treponema denticola, and porphyromonas gingivalis - implicated in the ... | 2014 | 24736700 |
| genetic analysis of porphyromonas gingivalis (fima), aggregatibacter actinomycetemcomitans, and red complex in coronary plaque. | the objective of the present study was to detect the presence of porphyromonas gingivalis (fima), aggregatibacter actinomycetemcomitans, and red complex in the coronary plaque of patients with coronary artery disease. | 2014 | 23447375 |
| oral hygiene reinforcement in the simplified periodontal treatment of 1 hour. | to compare the clinical and microbiological outcome of the 1-h ultrasonic debridement of chronic periodontitis patients (cpp) with and without frequent sessions of oral hygiene reinforcement. | 2014 | 24255993 |
| anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. | the objective of the study is to compare the clinical, microbiological and host-derived effects in the non-surgical treatment of initial peri-implantitis with either adjunctive local drug delivery (ldd) or adjunctive photodynamic therapy (pdt) after 12 months. | 2014 | 23560645 |
| [effect of er:yag laser on the dynamic changes in subgingival flora in type 2 diabetic patients with periodontitis]. | to observe the changes in subgingival microflora before and after er:yag laser treatment on diabetic patients with periodontitis, and to compare with the subgingival microflora of chronic periodontitis. | 2014 | 24881214 |
| oral status in patients with early rheumatoid arthritis: a prospective, case-control study. | patients with ra suffer from a higher risk of periodontal attachment loss and increased oral inflammation. we hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced ra. the primary objective of the present study was to determine whether a loss of alveolar bone can be detected in ra patients during the early course of the disease. | 2014 | 24273047 |
| the s-layer proteins of tannerella forsythia are secreted via a type ix secretion system that is decoupled from protein o-glycosylation. | conserved c-terminal domains (ctd) have been shown to act as a signal for the translocation of certain proteins across the outer membrane of bacteroidetes via a type ix secretion system (t9ss). the genome sequence of the periodontal pathogen tannerella forsythia predicts the presence of the components for a t9ss in conjunction with a suite of ctd proteins. t. forsythia is covered with a two-dimensional crystalline surface (s-) layer composed of the glycosylated ctd proteins tfsa and tfsb. to inv ... | 2014 | 24943676 |
| comparison of culture and polymerase chain reaction techniques in the identification of tannerella forsythia in periodontal health and disease, an in vitro study. | various bacterial species from subgingival biofilm have demonstrated aetiological relevance in the initiation and progression of periodontitis. the aim of this study was to detect the presence of tannerella forsythia (tf) in subgingival plaque of periodontally healthy subjects and chronic periodontitis patients by using both culture and pcr technique and compare the two techniques. | 2014 | 24872621 |
| ancient human oral plaque preserves a wealth of biological data. | a new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. the authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins. | 2014 | 24675519 |
| tannerella forsythia bspa increases the risk factors for atherosclerosis in apoe(-/-) mice. | the aim of this study was to evaluate the effects of tannerella forsythia and its major surface virulence factor, bspa, on the progression of atherosclerosis in apoe(-/-) mice and the expression of lipid metabolism-related genes. | 2014 | 24372897 |