Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the effect of rowson-parr virus on the severity of malaria in mice. | 1974 | 4375171 | |
| inhibition of the immune response to pertussis vaccine during plasmodium berghei yoelii infection in mice. | mice infected with plasmodium berghei yoelii responded poorly to pertussis vaccine when administered at peak parasitemia. this was shown by serum agglutinin titers and lack of protection against intracerebral challenge with virulent bordetella pertussis. | 1974 | 4375413 |
| optical isomers of aryl-2-piperidylmethanol antimalarial agents. preparation, optical purity, and absolute stereochemistry. | 1974 | 4588275 | |
| 4(1h)-quinolones. 2. antimalarial effect of some 2-methyl-3-(1'-alkenyl)-or-3-alkyl-4(1h)-quinolones. | 1974 | 4588278 | |
| a comparative account of the effects of betamethasone on mice infected with plasmodium vinckei chabaudi and plasmodium berghei yoelii. | 1974 | 4592839 | |
| synthesis of 2,4-diamino-5-(4-arylthiophenyl)-and 5-(4-arylsulfonylphenyl)pyrimidines as antimalarials. | 1974 | 4590245 | |
| sulfide, disulfide, and sulfone derivatives of 2-phenylcinchoninic acid as antimalarial congeners. | 1974 | 4590249 | |
| proceedings: hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. | 1974 | 4150466 | |
| 8-(omega-aminoalkylamino)quinolines as potential prophylactic antimalarials. | 1974 | 4151456 | |
| observations on the sporogonic cycle of plasmodium berghei in two australasian anophelines. | 1974 | 4152304 | |
| assessment of causal prophylactic activity in plasmodium berghei yoelii and its value for the development of new antimalarial drugs. | the causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced infections of nmri mice with plasmodium berghei yoelii (strain 17x). the animals were inoculated with 10 000 sporozoites per mouse and treated once 2-4 hours later. the test system has proved to be very suitable in experiments involving more than 3 000 mice. the infection rate in 448 untreated controls was 97.3%. lowering the sporozoite content of the inoculum to 1 000 ... | 1974 | 4155355 |
| surface properties of extracellular malaria parasites: morphological and cytochemical study. | morphological and cytochemical surface characteristics of isolated malaria parasites (plasmodium berghei) and host erythrocytes were compared by electron microscopy by using thin section and carbon replica techniques. erythrocytes were uniform in shape and had fine, granular surfaces. in contrast, free parasites exhibited a variety of sizes, shapes, and surface textures. fine surface stippling was a common topographical feature of isolated parasites. small, infective forms often had patterned su ... | 1974 | 4132619 |
| studies on the motility of plasmodium sporozoites. | 1974 | 4138523 | |
| synthesis of potential antimalarial agents. preparation of some 6-amino-5,8-dimethoxyquinolines and the corresponding 6-amino-5,8-quinolinediones. | 1974 | 4598023 | |
| naphthothiophenes. 4. preparation of multisubstituted 4-naphtho(2,1-b)thiophenemathanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho(2,1-b)thiophenemethanols. | 1974 | 4598132 | |
| antimalarials. 6. synthesis, antimalarial activity, and configurations of racemic alpha-(2-piperidyl)-4-pyridinemethanols. | 1974 | 4598133 | |
| synthesis and antimalarial activity of anthracene amino alcohols. | 1974 | 4598134 | |
| antimalarials. 2. alpha-di-n-butylaminomethyl-2-(p-chlorophenyl)-5-quinazolinemethanol. | 1974 | 4598262 | |
| effective recovery and immunity to virulent malaria following red cell transfusion at crisis. | 1974 | 4599485 | |
| potential antimalarials. 8. some 10-substituted 9-phenanthrenemethanols. | 1974 | 4599520 | |
| antimalarial, antiamoebic and toxicity tests on gentianine. | 1974 | 4599567 | |
| high-affinity accumulation of chloroquine by mouse erythrocytes infected with plasmodium berghei. | washed erythrocytes infected with chloroquine-susceptible (cs) or with chloroquine-resistant (cr) p. berghei were used in model systems in vitro to study the accumulation of chloroquine with high affinity. the cs model could achieve distribution ratios (chloroquine in cells: chloroquine in medium) of 100 in the absence of substrate. 200-300 in the presence of 10 mm pyruvate or lactate, and over 600 in the presence of 1 mm glucose or glycerol. in comparable studies of the cr model, the distributi ... | 1974 | 4600044 |
| the mitochondria of pre-erythrocytic plasmodium berghei. | 1974 | 4600125 | |
| ultrastructural analysis of plasmodium berghei sporozoite antigens prepared by freeze thawing and heat inactivation. | 1974 | 4600225 | |
| synthesis of analogs of 6-arylthio-, 6-arylsulfinyl-, and 6-arylsulfonyl-2, 4-diaminoquinazolines as potential antimalarial agents. | 1974 | 4600305 | |
| the chemotherapy of rodent malaria, xix. the action of a tetracycline derivative, minocycline, on drug-resistant plasmodium berghei. | 1974 | 4602012 | |
| fluorescent-antibody cross reactions between four blood parasites. | 1974 | 4602679 | |
| dihydropteroate synthetase from plasmodium berghei: isolation, properties, and inhibition by dapsone and sulfadiazine. | 1974 | 4602912 | |
| the surface of the malaria parasite. i. scanning electron microscopy of the oocyst. | 1974 | 4602986 | |
| synthesis and screening of potential antimalarial agent alpha-(2-piperidyl)-2-(1-adamantyl)-6,8-dichloro-4-quinolinemethanol hydrochloride. | 1974 | 4605197 | |
| a structural modification study of the antimalarial 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran. | 1974 | 4606154 | |
| amodiaquine analogs. synthesis of 6-((3-(n,n-diethylamino)methyl-4-hydroxy)anilino)5,8-dimethoxy-2,4-dimethylquinoline and related compounds. | 1974 | 4606204 | |
| antimalarials. 4. tetrahydroquinolinemethanols. | 1974 | 4606233 | |
| chemotherapy of rodent malaria: transfer of resistance vs mutation. | 1974 | 4606333 | |
| plasmodium berghei berghei: ectopic development of the anka strain in anopheles stephensi. | 1974 | 4606913 | |
| plasmodium berghei: possible role of thyroxine in growth and metabolism. | 1974 | 4606914 | |
| quinazolines. 12. 1,3-diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. synthesis and biological evaluation as candidate antifolate and antimalarial agents. | 1974 | 4606974 | |
| scanning electron microscope observations of plasmodium berghei ookinetes in primary mosquito cell cultures. | 1974 | 4607047 | |
| slow maturing primary exo-erythrocytic schizonts of plasmodium berghei in an experimentally infected tree-rat (thamnomys surdaster). | 1974 | 4607414 | |
| variation in glutamate dehydrogenase in subspecies of plasmodium berghei. | 1974 | 4607629 | |
| selections of anopheles gambiae species a for susceptibility and refractoriness to malaria parasites. | 1974 | 4607768 | |
| proceedings: the effect of mouse haemoglobins of plasmodium berghei and babesia rodhaini infections. | 1974 | 4607933 | |
| proceedings: the interaction between an ascites tumour and rodent malarias in mice. | 1974 | 4607934 | |
| letter: relation between plasmodium berghei and hepatosplenic and blood rates of paba and folates in mice. | 1974 | 4608060 | |
| synthesis and antimalarial evaluation of 9,10-dihydrophenanthrene amino alcohols. | 1974 | 4608227 | |
| an experimental approach to the demonstration of a single generation of exo-erythrocytic schizonts in plasmodium berghei. | 1974 | 4609378 | |
| erythropoietin production in virulent malaria. | erythropoietin, the hormone responsible for stimulating erythrocyte production, was shown to increase significantly in the serum of mice during virulent malaria infection. although erythropoiesis was enhanced, it did not keep pace with the rate of erythocyte destruction; hence all plasmodium berghei-infected mice quickly succumbed to the deleterious consequences of severe uncompensated hemolytic anemia. since this apparently inadequate rate of erythropoiesis is not attributed to impaired erythro ... | 1974 | 4609912 |
| in vitro ookinete development of the rodent malarial parasite, plasmodium berghei. | 1974 | 4610107 | |
| babesia microti and plasmodium berghei yoelii infections in nude mice. | 1974 | 4610411 | |
| host-cell specific proteolytic enzymes in plasmodium berghei infected erythrocytes. | 1974 | 4610782 | |
| influence of allopurinol on the multiplication of rodent malaria parasites. | 1974 | 4610931 | |
| comparison of the effects of neonatal thymectomy on plasmodium berghei, trypanosoma lewisi and trypanosoma cruzi infection in the albino rat. | 1974 | 4611081 | |
| immunity to plasmodium berghei in rats: passive serum transfer and role of the spleen. | pools of rat antiserum to plasmodium berghei had different levels of protective activity as assessed by a passive transfer test. preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. removal of the antiserum from preincubated parasite inocula abolished the bulk of protective activity. similarly, antiserum effective in intact animals was largely ineffective in splenectomized recipients. these experiments suggest a minimal role ... | 1974 | 4611920 |
| plasmodium berghei ookinete formation in a nonvector cell line. | 1974 | 4612127 | |
| malaria and the permeability of the host erythrocyte. | 1974 | 4612377 | |
| [treatment of drug-resistant malaria: animal experiments]. | 1974 | 4613506 | |
| ultrastructural studies on the early ookinete stage of plasmodium berghei nigeriensis and its transformation into an oocyst. | 1974 | 4614723 | |
| acid hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. | 1974 | 4614726 | |
| the effect of plasmodium berghei and trypanosoma brucei infections on the immune expulsion of the nematode trichuris muris from mice. | 1974 | 4615070 | |
| the uptake and incorporation of nucleosides into normal erythrocytes and erythrocytes containing plasmodium berghei. | 1974 | 4615289 | |
| suppression of schistosome granuloma formation by malaria in mice. | plasmodium berghei yeolii infection in mice suppressed granuloma formation around schistosoma mansoni eggs in the lungs. this suppressive effect was observed as early as 4 days after schistosome eggs were injected into malaria-infected mice and the maximum suppressive effect was seen by the 16th day. at this time granulomas in control mice than in mice infected with malaria. these data suggest that malaria has a direct influence on an immunologic reaction of the delayed hypersensitivity type. th ... | 1974 | 4615597 |
| the selection of arylamidinourea antimalarials by their predicted physicochemical properties. | 1 a small group of arylamidinoureas for which the predicted physicochemical properties were widely spaced and uncorrelated was selected for study.2 the antimalarial activity of each compound was measured against three species of plasmodium. three corresponding regression equations were calculated relating the potency of each compound to its predicted physicochemical properties.3 the potency of further test compounds was forecast for each species, by using the corresponding regression equation. t ... | 1974 | 4615765 |
| erythrocyte atp levels in mice infected with plasmodium berghei malaria. | 1974 | 4617309 | |
| effect of hypothyroidism on parasitemia and survival in rodent malaria. | 1974 | 4617503 | |
| development and decline of antiplasmodial indirect fluorescent antibodies in mice infected with plasmodium berghei (nk65) and treated with drugs. | malaria parasites in mice present a simplified rodent model for the immunological study of malaria. experiments have been performed to determine the pattern and persistence of malaria antibody as detected by the indirect fluorescent antibody (ifa) test utilizing specific antimouse igm and igg conjugates. the antibody levels in mice inoculated with plasmodium berghei and treated with antimalarial drugs were traced after complete elimination of the parasites from the host. within 1-2 weeks after i ... | 1974 | 4617640 |
| [immunological aspects of plasmodium berghei infections (action of cortisone in therapeutic doses)]. | 1974 | 4618434 | |
| [evaluation of anti-plasmodium antibodies in idiopathic african splenomegaly]. | 1974 | 4618790 | |
| modification by a latent contaminant of glomerular pathology in mice infected with plasmodium berghei. | this study was designed to determine, by means of electron microscopy, the effect of latent contaminants-which are associated with the syringe passage of the parasite-on the findings in the glomeruli of p. berghei-infected mice. a rapid alteration of the glomerular basement membrane was observed in mice infected with the syringe-transmitted n strain, but not in those infected with the cyclically passaged nig strain. glomerular changes were also seen in mice inoculated with nonparasitized blood f ... | 1974 | 4619058 |
| prevention of drug resistance in rodent malaria by the use of drug mixtures. | development of resistance to chloroquine in rodent malaria is inhibited by giving this compound together with a potentiating mixture of pyrimethamine and sulfadoxine but this does not prevent the development of resistance to the last two compounds. the use of drug mixtures should be explored as a means of "protecting" chloroquine or new blood schizontocides intended for mass chemotherapy against human malaria. however, no general rule can be laid down without testing specific drug mixtures in lo ... | 1974 | 4619060 |
| [research on congenital plasmodium berghei berghei malaria in mice. transplacental passage of the parasite and its evolution]. | 1974 | 4619061 | |
| [characterization of the antigen produced by solubilization of cell membranes of plasmodium berghei]. | 1974 | 4620172 | |
| labeling of sporozoites of plasmodium berghei with tritiated purines. | 1974 | 4595208 | |
| plasmodium berghei: experimental rodent model for malarial renal immunopathology. | 1974 | 4595293 | |
| brain capillary blockage produced by a virulent strain of rodent malaria. | a sudden enhancement in virulence of a mild plasmodium berghei yoelii 17 x strain resulted in fulminating and fatal infections in cf1 and a/j mice. the virulent strain has maintained its characteristics after ten cyclical transmissions through anopheles stephensi. the visible expression of virulence of the mutated strain is its ability to cross the blood-brain barrier and cause intravascular sequestration of injected erythrocytes and blockage of brain capillaries. we, therfore, believe that the ... | 1974 | 4595458 |
| antimalarial quinones for prophylaxis based on a rationale of inhibition of electron transfer in plasmodium. | knowledge of the biochemistry of plasmodium is emerging as a new field. previous studies showed that the parasite apparently requires electron transfer for energy, and techniques to study such energy mechanisms are available. the discovery of the existence of coenzyme q(8) in plasmodium implies an indispensable functionality for this redox entity in the electron transfer of the parasite, as coenzyme q(n) similarily functions in other forms of life. effective antimalarial activity in prophylaxis ... | 1974 | 4595578 |
| proceedings: ultrastructural changes following treatment of plasmodium berghei with quinine, and with a 9-phenanthrenemethanol, wr 122, 455. | 1974 | 4594465 | |
| proceedings: ultrastructural studies of the oökinete of p. b. nigeriensis. | 1974 | 4594466 | |
| cross immunofluorescent reactions between human and rodent malaria. | 1974 | 4594072 | |
| amodiaquin accumulation by mouse erythrocytes infected with plasmodium berghei. | 14camodiaquin accumulation by washed erythrocyte preparations was characterized to permit comparisons with chloroquine accumulation. erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible) accumulate amodiaquin by a saturable process that has an apparent dissociation constant for amodiaquin of 7.6 x 10(-8) m and is competitively inhibited by chloroquine, quinine and quinacrine, as is the process of chloroquine accumulation. within experimental error, the k1 of 8 x 10(-7) m est ... | 1975 | 488 |
| refeeding-malaria and hyperferraemia. | during the central african (sahelian) drought, attacks of falciparum malaria were common in patients and their relatives shortly after their arrival in a hospital in eastern niger. a prospective study of 72 adult patients not admitted for malaria and 109 accompanying relatives was undertaken to investigate this observation. 23 attacks occurred in patients and 51 in relatives, with a peak frequency five days after arrival. on arrival, parasitaemia was low but reached a maximum by five days. s ... | 1975 | 47080 |
| enhanced cytotoxicity in mice of combinations of concanavalin a and selected antitumor drugs. | concanavalin a (con a) injected intraperitoneally at a dose of 50 mg per kg was not lethal for male balb/c mice. six hours after administration of 5 mg con a/kg, the proportioy 24 hr, the proportion of granulocytes had decreased to 56%. adiministration of 5 mg con a/kg 24 hr before 200 mg of 5[3,3-bis(2-chloroethyl)-triazeno]-imidazole-4-carboxamide per kg, or 100 mg of 5-fluorouracil per kg resulted in a significant enhancement of lethality. simulatenous administration of 5 mg con a/gm and 10 m ... | 1975 | 168746 |
| malaria studies in vitro. iv: chloroquine resistance and the intracellular ph of erythrocytes parasitised with plasmodium berghei. | the erythrocytic stages of strains of plasmodia sensitive to chloroquine (cq) concentrate some three to six times more drug than cq-resistant strains. a simple, but so far untested hypothesis is that the intracellular ph of drug resistant strains is higher than that for sensitive strains. this would result in a reduced accumulation of any weakly basic drug molecule (e.g. cq) which is capable of passive diffusion through the cellular membran. the mean intracellular ph of erythrocytes parasitised ... | 1975 | 239645 |
| proceedings: changes in pha and lps responsiveness in murine malaria. | 1975 | 766318 | |
| proceedings: the passive transfer of immunity to plasmodium berghei yoelii. | 1975 | 766319 | |
| proceedings: the t-cell response in murine malaria. | 1975 | 766320 | |
| proceedings: pharmacology of plasmodium berghei. | 1975 | 766321 | |
| the plasmodium berghei-infection in isogenic f1 (c57bl x dba)-mice. i. the course of the infection and immunization experiments. | the malarial infection caused by plasmodium berghei (strain k 173) was observed in the isogenic mouse strains c3h, c57bl, dba, and the f1 (c57bl x dba)-hybrids. in addition immunization experiments were carried out by intermittent suppression of the parasite multiplication through maintaining the infected animals on a milk diet for various length of time. the f1-hybrids were the most resistant mice and immunization was most effective in these animals, too. but if the course of the infection was ... | 1975 | 766337 |
| dynamics of thymidine incorporation by spleen cells from rats infected with plasmodium berghei. | the in vitro incorporation of thymidine by spleen cells of rat infected with plasmodium berghei was higher than that of normal rat spleen cells. the incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. at the same time, the response of the malarious spleen cells to phytohaemagglutinin (pha) was only on ... | 1975 | 765025 |
| proceedings: the chemotherapeutic action of pam-780 against plasmodium berghei malaria in mice. | 1975 | 775791 | |
| spleen reactivity in experimental malaria of rodents. | 1975 | 776124 | |
| chronic malarial infection in balb/c mice. effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen. | chronic malarial infection was established in balb/c mice by following plasmodium berghei yoelii with p.b. berghei infection. it was found that the igg plaque-forming cell response to sheep erythrocytes was depressed for at least six months. a preliminary investigation of the histological changes in the spleen and liver is described. the possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed. | 1975 | 779156 |
| [behavior of a strain of p.berghei after low temperature preservation during more than 10 years]. | 1975 | 782384 | |
| [preparation and biological trials of antimalarial sulfa embonates]. | with the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. six of the seven embonates prepared showed activity against plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine). | 1975 | 788077 |
| pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in plasmodium berghei. | 1975 | 1108883 | |
| inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes. | 1975 | 1089545 | |
| motility of plasmodium berghei ookinetes in vitro. | 1975 | 1089734 | |
| plasmodium berghei: thyroid hyperplasia and thyroid hyperactivity in mice. | 1975 | 1090441 | |
| regional immunosuppression induced by plasmodium berghei yoelii infection in mice. | plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes. | 1975 | 1090525 |
| the in vitro culture of the blood stages of plasmodium berghei. | 1975 | 1090550 | |
| humoral immunity in rodent malaria. iii: studies on the site of antibody action. | serum which protects rats against plasmodium berghei infections fails to sensitize parasitized erythrocytes in vitro for in vivo destruction. further, the efflux of 86rb from parasitized erythrocytes in the presence of complement is not accelerated. on administration to animals with preexisting malaria, it does, however, produce a relatively slow decline in parasitemia, a phenomenon interpreted in terms of the gradual production and/or release of reactive antigenic determinants associated with m ... | 1975 | 1090670 |