Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [new acquisitions in the therapy of trichomonas vaginalis vaginitis]. | 1975 | 1166170 | |
| a method for the diagnosis of trichomonas vaginalis using acridine orange. | 1975 | 1185441 | |
| [intravaginal infection of the rat with trichomonas vaginalis and candida albicans. an experimental model for chemotherapy (author's transl)]. | ovariectomised and oestrogen premedicated rats were infected intravaginally, with first c. albicans and then with t. vaginalis. under these conditions infections with t. vaginalis could be established with more reliability than when using axenically-cultivated t. vaginalis alone. this mode of infection is easily reproduced, and it allows the performance of chemotherapeutic tests on small groups of laboratory animals. such tests were carried out with metronidazole, tinidazole and nifuratel. | 1975 | 1216328 |
| single dose treatment of trichomonas vaginalis with tinidazole (fasigyn). | 1975 | 1224628 | |
| treatment of trichomonas vaginitis with a single dose of tinidazole. | trichomonas vaginalis is a flagellate protozoon which in women commonly causes vaginal itching; burning, and a frothy, offensive and seropurulent yellowish discharge. incidence of infection in women varies from 13 to 60%, and is highest during pregnancy because of excess estrogens and in women with poor hygiene or with vaginitis. in men, the incidence ranges from 9 to 37% of persons with urethral discharge. this study presents the results of the use of a single dose treatment of trichomonas va ... | 1975 | 1236491 |
| [early identification of cancer through vaginal cytology in a venereal disease clinic]. | 100 women, routinely and regularly examined in a venereal disease clinic, have been investigated using papanicolaou smears of the uterine cervix for. 1. papanicolaou group, 2. trichomonas infection, 3. assessment of vaginal microbiology. a group iii was determined in 11, a group iv/v in 2 women. trichomonas vaginalis was present in 60% of the cases. only 9% of the smears showed normal döderlein bacteria; 91% contained mixed bacteria. the findings are compared with a control group and are discuss ... | 1975 | 1243854 |
| [study of the effect of the enzyme hyaluronidase on the pathomorphological changes in certain internal organs in white mice infected intraperitoneally with tr. vaginalis]. | the authors injected daily a dose of 5 l hyaluronidase diluted in 0,5 ml of saline, in 25 out of 50 white mice, contaminated with tr. vaginalis intraperitonealy. the remaining 25 mice formed the control group and were injected only with saline. the administration was made intraperitonealy. an equal number of mice from both groups were killed on the 30th and 40th day of contamination and the macroscopic changes in the abdominal cavity were examined. histological examinations of liver, spleen and ... | 1975 | 1083339 |
| [cytochemical study on lipase and nucleic acid in trichomonas vaginalis] | cytochemical demonstrations of lipase and nucleic acid in trichomonas vaginalis were attempted. modified gomori tween method for lipase and acridine orange method for nucleic acid was applied. trichomonas vaginalis incubated in the isolation mediurn (c.p.l.m.) were pooled and fixed using 0.1 n mcilvaine buffer saline and cold acetone for lipase and walpole acetate buffer saline and acetic alcohol for nucleic acid. the results were obtained as follows: activity of lipase and nucleic acid were rec ... | 1975 | 12913466 |
| uptake of metronidazole and its effect on viability in trichomonads and entamoeba invadens under anaerobic and aerobic conditions. | [(14)c]metronidazole used at the chemotherapeutic concentration of 10 mug/ml is taken up rapidly by the anaerobic protozoa tritrichomonas foetus, trichomonas vaginalis, and entamoeba invadens kept under anaerobic conditions. it can be calculated that within 30 to 60 min the intracellular concentration of the label is 50 to 100 times higher than in the medium. the presence of air markedly suppresses the uptake in the trichomonads and abolishes it in e. invadens. the suppression disappears after a ... | 1976 | 1083712 |
| the size, density, and relative area of chromatic granules ("hydrogenosomes") in trichomonas vaginalis donne from cultures in logarithmic and stationary growth. | electron micrographs of trichomonas vaginalis cells were examined morphometrically by means of an electronic image analyser. cells from cultures in logarithmic growth contained smaller chromatic granules ("hydrogenosomes") and a higher proportion of sausage- or dumb-bell-shaped granules than did cells in stationary growth. these findings support the view that chromatic granules replicate by division of pre-existing granules and that this involves elongation and attenuation of their mid-region. t ... | 1976 | 1083767 |
| [trichomoniasis in girls]. | 1976 | 1083971 | |
| in vitro effect of metronidazole on the ultrastructure of trichomonas vaginalis donné. | the effect of metronidazole on the growth and fine structure of exponeentially growing cells of trichomonas vaginalis was examined. cell division stopped about one hour after the addition of 1-4 mug/ml of metronidazole, and the cells were apparently arrested in the interphase. one to two hours after the addition of metronidazole, the movement of flagella and of the undulating membrane had decreased, but cell death had not occurred until 7-8 hours later. the fine structure of the cytoplasm was ch ... | 1976 | 1084098 |
| [in vitro sensitivity of trichomonas vaginalis to canestan (clotrimazole)]. | 1976 | 1087423 | |
| sensitivity of trichomonas vaginalis to metronidazole, tinidazole, and nifuratel in vitro. | prompted by the sensitivity of trichomonads to metronidazole and nifuratel in clinical practice, a study was conducted in 1971-1972 of 63 consecutive strains of trichomonas vaginalis isolated from women with clinically refractory vaginal discharge. their susceptibility to metronidazole, tinidazole, and nifuratel was tested, using a serial tube dilution technique. the minimum concentrations which in 48 hrs caused immobilization and lysis of trichomonads cultured in diamond's medium was assessed. ... | 1976 | 1087577 |
| the effect of chlorine and its compounds used for disinfection of water on trichomonas vaginalis. | 1976 | 1087786 | |
| [vaginal flora in women from gevgelija]. | the author gives data on the vaginal flora of women aged 20--64 in the commune of gevgelia obtained in the course of an early mass detection of the carcinoma of the uterine cervix in this area. the action covered 70.5% of women from urban areas and 85.3% of women from rural areas. the microbiological analysis of vaginal flora was made in two ways: first, by taking smears and by vital staining and classifying them after jirovec, peter, and malik; another preparation was sent to the cytologist and ... | 1976 | 1087944 |
| [immobile and circular forms of trichomonas vaginalis]. | 1976 | 1088186 | |
| [quantitative study on the "in-vitro" trichomonicide effect of tinidazole (beta-1-ethyl-sulfonyl-ethyl 2 methyl-5-nitroimidazole) on recently isolated strains of trichomonas vaginalis]. | 1976 | 1088519 | |
| [the influence of antimetabolites on trichomonas vaginalis as an experimental model]. | the present study was concerned with the relationship between antimetabolites and trichomonas vaginalis. in all of the strains (with p-nitrobenzylether of n-acetyldiiodtryrosine) tested, the growth of trichomonas vaginalis was identical to that of the control series at concentrations up to 2 mg/ml. at higher concentrations a decrease in multiplication was noted. in the experimental series with antitrypsin, from 1 mg/ml produced an inhibiting effect upon the trichomonas population. further invest ... | 1976 | 1088559 |
| [value of the modified roiron medium for the simultaneous detection of urogenital tract infection by trichomonas vaginalis and yeast-like fungi in humans]. | 1976 | 1088589 | |
| [role of exogenous factors in the development of intraepithelial lesions of the uterine cervix (author's transl)]. | 1976 | 1084730 | |
| [the action of prostatic secretion on trichomonas vaginalis (author's transl)]. | 1976 | 1085197 | |
| [pathogenic action and sero-immunologic phenomena of trichomonas vaginalis]. | trichomonas vaginalis is a frequent parasite of the urogenital system of the human been. the pathological manifestations are different with each strain. these variations of the pathogenic action of the parasite are found in the study of the experimental pathogenic action of the animal and in vitro on cell culture. the sero-immunological phenomens which lead to the presence of the parasite are not completely known. some technics was proposed for the diagnosis. their practical utilisation is not c ... | 1976 | 1085306 |
| new data on the mechanism and speed of action of nitroimidazoles on prokaryota and eukaryota with and without mitochondria. | the spectrum of action of nitroimidazoles ranges from anaerobic bacteria to aerobic bacteria which are also capable of growth, although sometimes with difficulty, in anaerobic atmosphere and to protozoa without and with mitochondria; in the latter case the anti-protozoal activity depends on the importance of the extramitochondrial enzymes which respond to nitroimidazoles. the more anaerobic the organisms, the greater their sensitivity. in the most sensitive protozoa, the trichomonads, most of th ... | 1976 | 1085631 |
| [frequency of trichomonas vaginalis infection in apparently healthy chilean women (1975) (author's transl)]. | 1976 | 1085634 | |
| [prevalence of trichomonas vaginalis infection in men from the city of santiago (chile, 1975) (author's transl)]. | 1976 | 1085635 | |
| application of wish cell cultures to produce large populations of vaginal trichomonads. | 1976 | 1085652 | |
| [pathology and clinical aspects of human trichomonas vaginalis infections]. | 1976 | 1085769 | |
| colonial morphology of trichomonas vaginalis in agar. | 1976 | 1086354 | |
| may trichomonas vaginalis provoke conjunctivitis? | in the world literature we have found descriptions of five cases of trichomonas vaginalis in the conjunctiva. conjunctival swabs taken from 122 patients with conjunctivitis or keratitis revealed no flagellate micro-organisms on phase-contrast microscopy and culture. neither did conjunctival swabs from 272 newborn infants, in spite of the fact that 3.7 per cent of their mothers had trichomonas in the vagina. trichomonas vaginalis is hardly likely to be responsible for conjunctivitis. | 1976 | 1086574 |
| study of female babies of women entering confinement with vaginal trichomoniasis. | a series of 868 women in the last 4 weeks of pregnancy were examined for the presence of t. vaginalis by direct microscopy of freshly prepared wet films and by three culture methods; 32 (3-7 per cent.) were found to give positive results. fourteen of the mothers with trichomoniasis at confinement had female babies, and these, together with a matching fourteen controls, were examined on three occasions by identical methods and within 21 days of birth. no baby gave positive results. on statistical ... | 1976 | 1083275 |
| [the etiopathogenesis of infectious vaginal inflammations]. | 1976 | 828248 | |
| [280 patients with urethritis]. | a study of 280 male patients with urethritis is presented. the frequency of infections caused by neisseria gonorrhoeae, trichomonas vaginalis, candida albicans and mycoplasma "t" is reported. some clinical characteristics of patients regarding the type of urethritis are described. literature on non-gonoccal urethritis is reviewed. | 1976 | 830050 |
| tinidazole: a review of its antiprotozoal activity and therapeutic efficacy. | tinidazole, a synthetic imidazole derivative, has been used in the oral treatment of several protozoal infections - trichomoniasis, giardiasis and amoebiasis. among the protozoal organisms inhibited by tinidazole are trichomonas vaginalis, trichomonas foetus, and entamoeba histolytica. in vitro, tinidazole has been shown to possess antiprotozoal activity at least comparable to, and in some cases greater than, metronidazole. tinidazole also has activity against some gram-negative anaerobic bacill ... | 1976 | 954609 |
| [short-term treatment of trichomonas vaginalis infection with metronidazole (flagyl forte)]. | 1976 | 968874 | |
| corynebacterium vaginale (haemophilus vaginalis) in women with leukorrhea. | corynebacterium vaginale was recovered from vaginal-cervical swab specimens in 164 of 288 women with leukorrhea and in four of 30 women without signs or symptoms of lower genital tract infection. the amount and character of the leukorrhea observed in association with c. vaginale infection were variable; in typical cases the discharge had the appearance of a thin paste. in a series of 100 patients studied to determine the apparent causes of leukorrhea, noninfectious causes were inferred in seven ... | 1976 | 984128 |
| tinidazole (fasigyn)--single-dose therapy for trichomonas vaginalis. | in this open evaluation trial, tinidazole in a single dose of 2 g proved highly effective in the treatment of trichomonal vaginitis in 25 women. there were minimal side effects and patient acceptance was good. | 1976 | 994982 |
| [single oral administration of fasigyn in the treatment of genitourinary trichomoniasis]. | in 35 women and 30 men with trichomoniasis one day therapy with fasigyn was applied. 8-th day after treatment trichomonas vaginalis was found in only three women and two men, but they were also curred by the repeated treatment. side effects were not observed. authors opinion is that this kind of therapy is specially acceptable in women with metrorhagia and those in preoperative care. | 1976 | 1018507 |
| single dose therapy of trichomoniasis with tinidazole. | tinidazole was used in a single dose of 2.1g for 52 patients found to have trichomonas vaginalis infection. husbands of 28 patients were also treated. the cure rate in 35 cases followed for 4 weeks or more was 100%. the drug was well tolerated. | 1976 | 817044 |
| group b streptococci in the female genital tract. | vaginal carriage rates of group b streptococci among 250 women attending a clinic for sexually transmitted diseases, 123 attending family planning clinics, and 110 in labour wages were 36.0%, 17-1% and 6.4% respectively. the presence of group b streptococci was not associated with a vaginal discharge or the use of oral contraceptives in the non-pregnant women, or with the isolation of neisseria gonorrhoeae or trichomonas vaginalis from the women attending the clinic for sexually transmitted dise ... | 1976 | 817770 |
| quantitation of neisseria gonorrhoeae from women with gonorrhea. | the number of infecting organisms has been shown to be an important variable in animal models of infection with neisseria gonorrhoeae. this variable may also be important in the natural transmission of gonorrhea in humans. the number of gonococci in the cervicovaginal area of women with gonorrhea is unknown, as are the effects of certain physiologic or therapeutic variables on the number of gonococci. in this study a semiquantitative technique for the enumeration of n. gonorrhoeae was used; 10 m ... | 1976 | 819594 |
| [etiology and pathogenesis of ascending gonorrhea in women]. | 1976 | 822627 | |
| [therapeutic trial of trichomonas vaginalis in male by using a single dose of tinidazole (author's transl)]. | 1976 | 786326 | |
| cervical bacterial flora in women fitted with a copper-releasing intra-uterine contraceptive device (iud). | a bacterial culture was taken from the cervix in 85 sexually active women before, and 3 and 6 months after, insertion of either a copper-releasing or an inert intra-uterine contraceptive device (iud). sixty had a copper-t (tcu-200) and 25 a lippes loop d. although in more than a quarter of the patients the bacterial flora increased slightly in diversity and abundance after iud insertion, there was no difference in effect between the tcu-200 and lippes loop d. | 1976 | 788452 |
| antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles. | twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on tritrichomonas foetus (kv(1)) and trichomonas vaginalis (atcc 30001) for mutagenicity on a nitroreductase-positive (ta 100) and a nitroreductase-deficient (ta 100-fr(1)) strain of salmonella typhimurium, as well as for the reducibility of the nitro group by t. foetus homogenates. compounds with activity <1% of that of ... | 1976 | 791102 |
| comparison of four techniques for the routine diagnosis of trichomonas vaginalis infection. | specimens from 495 patients attending johannesburg hospitals and family planning clinics were examined for trichomonas vaginalis by microscopy of giemsa (gs), papanicolaou (pap), and acridine-orange (ao) stained smears, and by culture in feinberg-whittington medium. culture, pap and gs stained smears from vaginal swabs yielded fewer positives than ao stained smears. although pap-stained cytological smears gave the highest number of positives, in 30% of these cases the presence of t.vaginalis cou ... | 1976 | 58872 |
| the fine structure of cells of trichomonas vaginalis donné obtained from the exponential phase of growth and from stationary cultures. | in cells of trichomonas vaginalis in logarithmic phase of growth (log. t. vaginalis) the number of free cytoplasmic ribosomes was higher than that in cells from stationary cultures (stat. t. vaginalis). polyribosomes closely surrounding the chromatic granules were present in equal amounts in both categories fo cells, which indicates that they have specific functions and are not directly involved in the protein synthesis of the growing cell. the volume of the golgi region and of the food vacules ... | 1976 | 60874 |
| [imidazoles in the treatment of infections due to parasitic protozoa "lumenals". (t. vaginalis, giardia intestinalis, e. histolytica--general principles)]. | 1976 | 196967 | |
| [infections transmitted in swimming pools]. | public swimmingpools can be the source of infections due to micro-organism such as mycobacterium balnei, adeno and enteroviruses, the virus of plantar warts and molluscum contagiosum, the tric-agent of swimmingpool-conjonctivitis and pathogenic fungi. the transmission of trichomonas vaginalis is considered unlikely-water of pools, supposed to present satisfactory qualities by standard controls, was found to contain pathogenic staphylococci and pseudomonas aeruginosa. effective preventive measure ... | 1976 | 186978 |
| [pharmacologic study of the amebicidal and trichomonicidal activity of ornidazole (1-(2-hydroxy-3-chloropropyl)-2-methyl-5-nitroimidazole]. | 1976 | 188370 | |
| [study of the antiprotozoal activity of compounds of the series of diphenyl ethers and certain nitrostyrols]. | 1976 | 192989 | |
| microbiology of the female genital tract during pregnancy and parturition. | 1976 | 10196 | |
| synthesis and biological activity of some vinyl-substituted 2-nitroimidazoles. | in previous studies 1-methyl-2-nitro-1h-imidazole-5-carboxaldehyde and 1-methyl-2-nitro-5-vinyl-1h-imidazole were found to posses interesting antimicrobial activities. we have now prepared some 2-nitro-1h-imidazoles in which the 5-vinyl chain bears selected functional groups (cho, coch3, no2) as well as nitrogen-condensation derivatives of the carbonyl functions. furthermore, 5-methyl-2-nitro-1-vinyl-1h-imidazole has been synthesized. all the compounds, and some intermediates, have been assayed ... | 1977 | 16132 |
| a study of the possible value of acridine orange-o strain in the diagnosis of trichomonas vaginalis infection. | 1977 | 66993 | |
| [pictures of t. vaginalis obtained by a modified method of staining cytological preparations]. | 1977 | 75611 | |
| 1,4-bis-[1-methyl-5-nitroimidazolyl-(2-methyleneimino)]-piperazine, a new drug with marked activity against entamoeba histolytica. short communication. | 1,4-bis-[1-methyl-5-nitroimidazolyl-(2-methyleneimino)]-piperazine (hoe 316) administered orally produces an effect which is clearly superior to that of metronidazole against entamoeba histolytica in the golden hamster and slightly inferior against trichomonas fetus and t. vaginalis in the mouse. the acute tolerance of the compound is very good (ld 50% greater than 10 g/kg body weight). it is assumed that the possible main metabolite of hoe 316 is a monohydrazone: 1-methyl-2-(4-amino-piperazino- ... | 1977 | 195590 |
| microbiology of the female reproductive tract. v. changing patterns within one decade in a french canadian population. | 1977 | 299891 | |
| additional uses of polyvinyl alcohol (pva) in the fixation and staining of parasitic protozoa. | 1977 | 300520 | |
| [trichomoniasis. physiopathology and therapy]. | based on many years' experience with trichomonas vaginalis the author comes to the conclusion that trichomonads are much more common than expected. therefore the possibility of trichomoniasis shoudl be taken into account not only when discharge is found in females or persistent urethritis in males, but also in other affections. remote reactions may occur in either sex, e.g. prostatis or adnexitis. sterility is sometimes due to trichomonas vaginalis. apart from classical pictures in either sex ar ... | 1977 | 300704 |
| comparisons between direct microscopic and cultural methods for recognition of corynebacterium vaginale in women with vaginitis. | the frequency with which clue cells could be detected in gram-stained vaginal smears and/or cervical papanicolaou (pap) smears was compared with the frequency of corynebacterium vaginale (haemophilus vaginalis) isolation in a group of 236 female patients, of whom 221 had vaginitis. vaginal clue cells were found most often in women from whom c. vaginale was isolated (p = 0.00006) whereas, conversely, clue cells in cervical pap smears were reported more frequently in women with negative cultures f ... | 1977 | 300740 |
| [trichomonas vaginalis in patients with non-gonorrheal inflammation of the urogenital tract and in healthy subjects]. | 1977 | 300889 | |
| [presence of trichomonas vaginalis in the urethra and bladder of women with colpitis trichomonalis]. | 1977 | 300992 | |
| comparative studies on the trichomonacidal activity of 5-nitroimidazole-derivatives in mice infected s.c. or intravaginally with t. vaginalis. | the trichomonacidal efficacy of metronidazole, tinidazole, nimorazole and ornidazole was studied in mice infected s.c., or for comparison purposes intravaginally. in both test systems, the drugs revealed nearly the same order of efficacy, whereby the compounds showed a marked decrease of activity when analyzed in s.c. infected mice. | 1977 | 302218 |
| [diagnosis of asymptomatic trichomonas vaginalis in men]. | 1977 | 302456 | |
| biological properties and clinical application of propolis. ii. studies on the antiprotozoan activity of ethanol extract of propolis. | solutions of the ethanol extract of propolis (eep) have shown a lethal effect on trichomonas vaginalis in vitro. similar lethal action was exhibited by eep after a 24-h contact with toxoplasma gondii. | 1977 | 302709 |
| [study of trichomonas vaginalis resistance to metronidazol spofa (author's transl)]. | 1977 | 302730 | |
| [trichomonas vaginalis incidence in the material of the hygiene centre of bratislava city (1970-1975) (author's transl)]. | 1977 | 302731 | |
| [isolation of trichomonas vaginalis]. | 1977 | 303171 | |
| interference of human spermatozoal motility by trichomonas vaginalis. | human spermatozoa were exposed to concentrations of live trichomonas vaginalis varying from 10(4) to 10(7) organisms per ml. a striking decrease in spermatozoal motility ensued. the possible role of trichomoniasis in human reproductive failure is considered. | 1977 | 303705 |
| [bacteriostatic, antimycotic and antitrichomonal effects in vitro of a new antineoplastic drug, ledakrin, polfa]. | 1977 | 303764 | |
| [trichomonas vaginalis and cytological findings (author's transl)]. | the detection of trichomonas vaginalis by the method of the papanicolaou smear has proven as suitable. alterations of surface cells in the presence of trichomonas vaginalis are described, and causal relations between atypic cells and trichomonas vaginalis are discussed. from a total of 13000 in investigations of cancer screening in 1975, an infection with trichomonas vaginalis was found in 850 cases = 6,69 p.c. in contrast to this result 28 p.c. of the 116 patients with cancer of precancer of th ... | 1977 | 303893 |
| [some questions on the relationship between vaginal biocenosis and the course of pregnancy (proceedings)]. | 1977 | 304384 | |
| trichomonas vaginalis: effect of tinidazole on ultrastructure in vitro. | 1977 | 304415 | |
| [morphological variability of t. vaginalis in vivo and in vitro]. | 1977 | 305158 | |
| [t. vaginalis donné variability in axenic cultures evaluated in scanning electron microscope]. | 1977 | 305159 | |
| [rosette and vegetative form of trichomonas vaginitis in women of the wrocław district and the wrocław district management of state railroads examined in the years 1973-1975]. | 1977 | 305160 | |
| [reproduction of vaginal trichomonas depending on the conditions of their habitat]. | 1977 | 305161 | |
| [penetration by t. vaginalis of female uterine cavity]. | 1977 | 305162 | |
| [effect on t. vaginalis of vaginal contents following electrocoagulation of the uterine neck]. | 1977 | 305163 | |
| [comparison of the population density of t. vaginalis donné in cultures with fungi strains isolated from cases of trichomonadosis or trichomonadosomycosis]. | 1977 | 305164 | |
| [behavior of the common part of the uterus in guinea pigs following infection with t. vaginalis. i. mast cells]. | 1977 | 305165 | |
| [diagnosis of trichomonas vaginitis by means of the carbonate agglutination reaction]. | 1977 | 305166 | |
| [effect of vaginal microorganisms on the epithelium of the vaginal part of the uterus]. | 1977 | 305167 | |
| [antitrichomonal action of new beta-diethylaminethyl acetophenone, isoxazole and chromanone ethers]. | 1977 | 305168 | |
| [in vitro effects of tinidazole on selected microorganisms of vaginal ontocenosis in trichomonas vaginitis]. | 1977 | 305169 | |
| microbes associated with leucorrhoea. | 1977 | 305453 | |
| synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 h-imidazole, an antiprotozoal agent. | 5-(-hydroxyl-1-methylethyl-)-1-methyl-2-nitro-1 h-imidazole (6) and 5-(1,2-dihydroxyl-1-methylethyl)-1-methyl-2-nitro-1 h-imidazole (9) are the principal metabolites found in urines of animals (mice, rats, and dogs) treated with 1-methyl-5-(1-methylethyl)-2-nitro-1 h-imidazole (1), an effective antitrichomonas agent. these two metabolites have been synthesized. compound 6 was found to be less toxic than the parent compound 1 and to possess essentially the same activity against trichomonas vagina ... | 1977 | 199729 |
| immune response and degree of protection in mice immunized with trichomonas vaginalis antigen. | the immune response and degree of protection of mice immunized with t. vaginalis sonicated antigen injected by intraperitoneal route, intraperitoneal and intravaginal only has been studied. humoral response has been evaluated by indirect immunofluorescence and agglutination techniques; moreover, cytotoxicity of vaginal secreta has been investigated. cellular response has been evaluated by stimulation of peripheral lymph-node cells and spleen lymphocytes with t. vaginalis antigen. it has been obs ... | 1977 | 306940 |
| ornidazole: a new antiprotozoal compound for treatment of trichomonas vaginalis infection. | a new anti-protozoal compound, ornidazole, a derivative of nitroimidazole, was given in a single 2 g dose to 20 women with trichomonas vaginalis infection. all the women were cured, but they suffered some side-effects. plasma levels of ornidazole reached a peak five to eight times higher than minimum inhibitory concentrations and exceeded this level for at least 36 hours. it is therefore possible that a smaller dose might have had an adequate trichomonicidal effect and fewer side-effects. furthe ... | 1977 | 321095 |
| single dose of two grams of metronidazole for trichomonas vaginalis infection. | in this study, 243 women with symptomatic trichomonal vaginitis were treated with eight 250 mg. tablets of metronidazole for themselves, and eight tablets were given to each of their male consorts. they were given instructions to ingest "all eight in a row" and "avoid alcohol for 48 hours." ninety-five per cent of 203 women that returned for re-examination were cured. this single-dose treatment is effective, well tolerated, and less expensive than current recommended dosages. | 1977 | 324287 |
| [in vitro action of mepartricin in combination with chlortetracycline]. | the microbiological activity of a mepartricin + chlortetracycline hydrochloride association was evaluated on the principal agents causing cervico-vaginal infections. beside confirming the antimycotic and antiprotozoal efficacy of mepartricin, is was possible to demonstrate an absence of antagonism with chlortetracycline. on the other hand, in some cases this antibiotic could potentiate the antitrichomonas effect of mepartricin. | 1977 | 324437 |
| antibiotics produced by streptomyces olivaceus 142. ii. isolation, purification and activity spectrum of antibiotic wr 142-fpg. | a method of isolating antibiotic wr 142-fpg from the fermentation broth and mycelium of mutant fpg of the strain streptomyces olivaceus 142 has been developed. the method of purification of the active substance and activity spectrum agains microorganisms are described. some of the basic properties of two preparations are given: a) the preparation designed i, partly purified, containing a peptide moetye and b) the preparation designed ii, which is a homogeneous chromatographically preparation wit ... | 1977 | 326221 |
| comparison of ornidazole and tinidazole in single-dose treatment of trichomoniasis in women. | a comparison is made between oral ornidazole in a single 1-5 g dose and tinidazole given in a 2 g dose using a double-blind technique. all the 45 women with trichomonas vaginalis infection who were treated with ornidazole were cured. in the tinidazole-treated group 41 out of 43 women had negative cultures after treatment. tolerance was good in both groups. | 1977 | 326349 |
| [diagnosis of trichomonas vaginalis infestation in a fresh slide by the phase contrast microscopy (author's transl)]. | 1977 | 333419 | |
| n-substituted derivatives of em 49 structure-activity relationships. | 1977 | 336594 | |
| characteristics of some pathogenic fungi and trichomonas vaginalis donne in the scanning electron microscope. | 1977 | 345751 | |
| observations on trichomonas vaginalis infections in zambia. | microscopy and culture of high vaginal swabs from an ante-natal clinic showed that 38.5% of the women harboured trichomonas vaginalis; the corresponding figure from a gynaecology clinic was 31.4%. the incorporation of the culture method together with direct microscopy as a diagnostic technique in a routine laboratory is emphasized. urine microscopy in out-patients, in-patients and medical examinees indicates that t. vaginalis in both males and females is not a rare infestation but the prevalence ... | 1977 | 562376 |
| [the efficacy of established, systemically active trichomonacidal agents in the infection model tri-chomonas vaginalis/rat (author's transl)]. | experimental chemotherapeutical studies were carried out with metronidazole, tinidazole, nitrimidazine and ornidazole in rats infected with trichomonas vaginalis intravaginally. all compounds tested showed a systemic trichomonacidal activity within rather a narrow dosage range after three oral doses and also after a single dose, i.e., 1.4-3.0 mg/kg and 7.7-15.9 mg/kg body weight (dc50), respectively. | 1977 | 577434 |
| interrelationship of chlamydia trachomatis and other pathogens in the female genital tract. | the isolation of neisseria gonorrhoeae, chlamydia trachomatis, trichomonas vaginalis, and candida albicans in the female genital tract was studied in 1323 patients attending a venereal disease clinic. disruption of the cell monolayers use for the isolation of c. trachomatis was significantly associated with the presence of t. vaginalis; this effect was markedly reduced by the addition of vancomycin to gentamicin and amphotericin b in the transport and growth media. the only significant positive ... | 1977 | 412875 |
| [effect of t. vaginalis on the physiological vaginal flora]. | 1977 | 415437 |