Publications

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[possibility of determination of the value of the ejection fraction of the left ventricle with non-invasive methods in ischemic cardiopathy]. 20144080166
prevention of physical and mental congenital defects. part b: epidemiology, early detection and therapy, and environmental factors. proceedings of an international conference of the institut de la vie. strasbourg, france, october 10-17, 1982. 20143983156
postnatal development of the telencephalon of the tammar wallaby (macropus eugenii). an accessible model of neocortical differentiation.the sequence of development of cell layers in the neocortex of the tammar has been followed from 24 days gestation to 213 days postnatal. the tammar is born at 27 days gestation and the major period of its development occurs during the subsequent 250 days, most of this time being spent within the pouch. although the pattern of differentiation of the cell layers appears to resemble that described for many eutherian mammals, the neocortex is at an embryonic 2 layered stage at birth and a cortical ...20144073534
[various problems relative to chemical aggression]. 20144235737
attention and prism adaptation. 20143995897
a new line on age pigment? 20144097957
[clinical and hemodynamic evolution of carpentier-edwards prostheses]. 20144015004
chronic pediatric tracheotomy: assessment and implications for habilitation of voice, speech and language in young children.the effect of chronic tracheotomy on the acquisition of voice, speech, and language skills was studied. children with chronological ages of 16 months to 41 months were evaluated for receptive communication age (rca) and expressive communication age (eca). results indicate a consistent deviation of (on the average) 4.8 months delay in rca and 9 months delay in eca. an habilitation program for early intervention in voice, speech and language stimulation is described, with follow-up data on 3 child ...20144030238
l-galactose metabolism in bacteroides vulgatus from the human gut microbiota.a previously unknown metabolic pathway for the utilization of l-galactose was discovered in a prevalent gut bacterium, bacteroides vulgatus. the new pathway consists of three previously uncharacterized enzymes that were found to be responsible for the conversion of l-galactose to d-tagaturonate. bvu0219 (l-galactose dehydrogenase) was determined to oxidize l-galactose to l-galactono-1,5-lactone with kcat and kcat/km values of 21 s(-1) and 2.0 × 10(5) m(-1) s(-1), respectively. the kinetic produc ...201424963813
[bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents - special references to bacteria isolated between april 2011 and march 2012].bacteria isolated from surgical infections during the period from april 2011 to march 2012 were investigated in a multicenter study in japan, and the following results were obtained. in this series, 785 strains including 31 strains of candida spp. were isolated from 204 (78.8%) of 259 patients with surgical infections. five hundred and twenty three strains were isolated from primary infections, and 231 strains were isolated from surgical site infection. from primary infections, anaerobic gram-ne ...201425796741
individually addressable arrays of replica microbial cultures enabled by splitting slipchips.isolating microbes carrying genes of interest from environmental samples is important for applications in biology and medicine. however, this involves the use of genetic assays that often require lysis of microbial cells, which is not compatible with the goal of obtaining live cells for isolation and culture. this paper describes the design, fabrication, biological validation, and underlying physics of a microfluidic slipchip device that addresses this challenge. the device is composed of two co ...201424953827
bacteroides dorei dominates gut microbiome prior to autoimmunity in finnish children at high risk for type 1 diabetes.the incidence of the autoimmune disease, type 1 diabetes (t1d), has increased dramatically over the last half century in many developed countries and is particularly high in finland and other nordic countries. along with genetic predisposition, environmental factors are thought to play a critical role in this increase. as with other autoimmune diseases, the gut microbiome is thought to play a potential role in controlling progression to t1d in children with high genetic risk, but we know little ...201425540641
senior thai fecal microbiota comparison between vegetarians and non-vegetarians using pcr-dgge and real-time pcr.the fecal microbiotas were investigated in 13 healthy thai subjects using polymerase chain reaction denaturing gradient gel electrophoresis (pcr-dgge). among the 186 dna bands detected on the polyacrylamide gel, 37 bands were identified as representing 11 species: bacteroides thetaiotaomicron, bacteroides ovatus, bacteroides uniformis, bacteroides vulgatus, clostridium colicanis, eubacterium eligenes, e. rectale, faecalibacterium prausnitzii, megamonas funiformis, prevotella copri, and roseburia ...201424743571
production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine.to examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation.201425339828
antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from pseudallescheria boydii, a beetle (coleoptera)-associated fungus.pseudallescheria boydii residing in the gut of coleopteran (holotrichia parallela) larva produces four new epipolythiodioxopiperazine (etp) boydines a-d (3-6) and two novel sesquiterpene boydenes a (7) and b (10), in addition to bisdethiobis(methylthio)-deacetylaranotin (1), bisdethiodi(methylthio)-deacetylapoaranotin (2), am6898 a (8) and ovalicin (9). the structure elucidation was accomplished by a combination of spectral methods with quantum chemical calculations of optical rotations and elec ...201425319640
bacterial sensor nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal bacteroides vulgatus.nod2 has been extensively characterized as a bacterial sensor that induces an antimicrobial and inflammatory gene expression program. therefore, it is unclear why nod2 mutations that disrupt bacterial recognition are paradoxically among the highest risk factors for crohn's disease, which involves an exaggerated immune response directed at intestinal bacteria. here, we identified several abnormalities in the small-intestinal epithelium of nod2(-/-) mice including inflammatory gene expression and ...201425088769
model-based hypothesis of gut microbe populations and gut/brain barrier permeabilities in the development of regressive autism.regressive autism is a devastating disorder affecting children between the ages of 15-30 months. the disorder is characterized by the loss of social interaction and communication ability following otherwise healthy development. in spite of rising autism prevalence, current detection methods and treatment options for this disease are lacking. therefore, this study introduces a systems-level model, which suggests that gut microbes and intestinal inflammation influence the onset of regressive autis ...201425288537
hla-b27 and human β2-microglobulin affect the gut microbiota of transgenic rats.the hla-b27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic arthritis, but its mechanism of risk enhancement is not completely understood. the gut microbiome has recently been shown to influence several hla-linked diseases. however, the role of hla-b27 in shaping the gut microbiome has not been previously investigated. in this study, we characterize the differences in the gut microbiota mediated by the ...201425140823
disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with lactobacillus gg: a randomised clinical trial.intestinal inflammation is a hallmark of cystic fibrosis (cf). administration of probiotics can reduce intestinal inflammation and the incidence of pulmonary exacerbations. we investigated the composition of intestinal microbiota in children with cf and analyzed its relationship with intestinal inflammation. we also investigated the microflora structure before and after lactobacillus gg (lgg) administration in children with cf with and without antibiotic treatment.201424586292
[laparoscopic extra- and intrahepatic angiography and pressure measurement]. 20144280624
[results of the treatment in fractures and dislocations of the cervical vertebrae. late results in 26 survivors]. 20144238935
reliability of glucose oxidase staining at the ultrastructural level for immunohistochemical studies. 20144111155
the periphery of descemet's membrane. a study by light microscopy. 20144173658
mathematical modelling of dynamics and control in metabolic networks. v. static bifurcations in single biochemical control loops.here we expand an earlier study of feedback activation in simple linear reaction sequences by searching the parameter space of biologically realistic rate laws for multiple stable steady states. the impetus for this work is to seek the origin of decision making strategies at the metabolic level, with particular emphasis on the switching between the operating conditions needed to meet changing substrate availability and organism requirements. the control loop considered herein is a linear reactio ...20143999779
monoclonal antibodies to drugs: novel diagnostic and therapeutic reagents. 20143911217
thymidine salvage pathway in normal and leukemic leukocytes with effects of atp on enzyme control. 20144305274
production of ai-2 is mediated by the s-ribosylhomocystein lyase gene luxs in bacteroides fragilis and bacteroides vulgatus.quorum sensing is a cell-cell signaling mechanism based on cell density and that involves the production of hormone-like molecules called autoinducers (ai). one of the most studied ais has been termed ai-2, and its biosynthesis requires the enzyme encoded by luxs. we have previously described for the first time that bacteroides species can produce molecules with ai-2 activity. in this study, we focus on the detection of luxs and its activity as the ai-2 synthase in bacteroides species. the strai ...201424026770
coexpression and secretion of endoglucanase and phytase genes in lactobacillus reuteri.a multifunctional transgenic lactobacillus with probiotic characteristics and an ability to degrade β-glucan and phytic acid (phytate) was engineered to improve nutrient utilization, increase production performance and decrease digestive diseases in broiler chickens. the bacillus subtilis wl001 endoglucanase gene (celw) and aspergillus fumigatus wl002 phytase gene (phyw) mature peptide (phywm) were cloned into an expression vector with the lactate dehydrogenase promoter of lactobacillus casei an ...201425050780
[therapeutic problems in acromegaly]. 20144029005
[behavior of the very difficult child in the dental office. i. the cause]. 20144274837
comparative mortality ratio--a health index. 20144077244
chromatin fibril size in salivary gland chromosomes of drosophila melanogaster. 20144202370
[late-onset damage to the supporting system of leg amputees]. 20144272554
[apparatus for electrophoresis in starch gel]. 20144139385
[long-term therapy of the chronic bronchitis syndrome using tanderil]. 20144992075
[provision for and requirement of vitamin pp in patients with glaucoma]. 20144272972
[provision for and requirement of vitamin pp in patients with glaucoma]. 20144272972
the effect of thyroxine on peripheral thyroid hormone metabolism. 20144187946
[radiologic observations on lumbalgias]. 20144221792
solute migration during granule drying. 20144156730
the co2 laser for recurrent and therapy-resistant condylomata acuminata.the medical records of 48 patients who underwent laser vaporization of therapy-resistant or recurrent condylomata acuminata were studied with regard to history of immunosuppression, location of original lesion, type and duration of therapy, and whether magnification devices were used prior to or during therapy. the genitalia of the patients' sexual partners were examined in all cases in which the condylomata recurred after initial control of the lesions with conventional methods. in 46 of the 48 ...20144020791
[scintigraphic studies of bones in hemoblastoses]. 20144111754
red cell 2,3-diphosphoglycerate in patients with hyperthyroidism before and after treatment. 20144139877
[new facts concerning the hormonal supervision of malignant trophoblastomas. differentiations of the principal pituitary or chorionic gonadotropins in castrated subjects]. 20144293151
antiviral resistance by the polyinosinic acid-poly (1-vinylcytosine) complex.the antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(i).poly(c)], which is a potent interferon inducer, have been studied. structural changes that modify the polymer backbone substantially, such as loops or 2' --> 5' phosphodiester bonds, lead to decreased antiviral activity. unexpectedly, however, the complex of polyinosinic acid and poly(1-vinylcytosine), which is only a much more distantly related analog of poly(i) . poly(c), shows h ...20144324924
[on the storage of mucopolysaccharide-like substances in the brain in generalized glycogenosis (type ii)]. 20144223251
[evolution and complications of suppurative meningitis]. 20144291410
[evolution and complications of suppurative meningitis]. 20144291410
role of pulmonary hypertension, hypoxaemia and right ventricular hypertrophy on the right heart failure in pulmonary heart diseases. 20144273123
invasion of privacy. 20143969230
[clinical picture and treatment of nocturnal enuresis in children].the article presents the results of the treatment of 275 cases of nocturnal enuresis which are subdivided by the author into 3 forms according to the nature of the pathogenesis: neurotic, organic and familial. the neurotic form of eneuresis showed the best response to a combination of hypnotherapy with tranquilizers and antidepressants, the organic form was most responsive to nootropic agents, antidepressants and anticonvulsants. antidepressants were effective for the treatment of familial enure ...20143993305
asymptomatic carotid bruit. stenosis or ulceration, a conservative approach. 20143985815
attachment of plaque and calculus to tooth surfaces. 20144255150
detectability of group-specific component (gc) in aged bloodstains.an improved method of group-specific component (gc) typing was conducted electrophoretically on agarose gel. individual bloodstains randomly collected from different individual donors over a five-year period at intervals of approximately one month were checked for gc activity. group-specific component was typed accurately in dried bloodstains stored at room temperature up to 43 months in age. from 100 different donors, bloodstains ranging in age from 38 to 43 months were tested by the methods de ...20144039746
microcomputers in clinical research: discussion paper. 20144020798
rickets from liquid paraffin. 20144164140
[management of congenital hip dislocation with the hanausek method as compared with conventional procedures]. 20144273488
short stature and growth hormone deficiency in histiocytosis x. 20144424388
short stature and growth hormone deficiency in histiocytosis x. 20144424388
symbolism in the treatment of schizophrenia. 20144195343
adverse effects secondary to baclofen withdrawal.drug therapy is now the preferred method of treatment for spasticity, and several effective agents have been developed. the safety and efficacy of these drugs has been established in short-term studies. overall, due to its low incidence of sedation and serious side effects, baclofen appears to be the drug of choice in the treatment of spinal cord-related spasticity. it is, however, not without its side effects due to both its administration and abrupt withdrawal. this case illustrates some signi ...20144006720
[diagnosis of lymphoma in abdominal lymph nodes]. 20143910869
[johann sebastian bach's eye operation and his surgeon sir john taylor]. 20143911076
[evaluation of a semiautomatic system (abac-abactor iii) for the identification of enterobacteriaceae].abac-abactor ii system has been compared with two conventional methods (enterotube ii and ms-2) for the identification of enterobacteriaceae. our findings demonstrate the validity and the reproducibility of the identification obtained with this system.20144059512
[normal fundi oculi in tumors of the posterior cranial fossa]. 20144319488
[normal fundi oculi in tumors of the posterior cranial fossa]. 20144319488
the pulmonary circulation in children with congenital heart disease: morphologic and morphometric considerations. 20143896433
[experimental data on the penetration of hexachlorane into the soil]. 20144112874
unhappiness and mental illness. 20154525690
[ovarian vein syndrome]. 20154704157
[ovarian vein syndrome]. 20154704157
fifty years of milford hospital. 20154557834
visual effects of subfusional rates of high-intensity intermittent photic stimulation. 20154517391
k.r. eissler's discourse on hamlet. a symposium. hamlet and ressentiment. 20154578625
custody of children and the law. 20154765874
[effects of dichlorvos and malathion on ascorbic acid level and the nutritional value of some vegetables]. 20154709861
[equipment and methods used in the hematologic services in czechoslovakia]. 20154653149
coronary arteriography: a review (second part). 20154614822
radiological case of the month. 20154854015
continuous elevation by spica cast in treatment of reflex sympathetic dystrophy. 20154452701
[electron microscopic study of the reversibility of sclerotic changes in the liver]. 20154615677
effect of testosterone on the lh and fsh release induced by lh-releasing factor (lrf) in normal men. 20154581339
significance and comparison of two methods for platelet aggregation. 20154642544
[a leading soviet surgeon alekseĭ petrovich krymov (on the 100th anniversary of his birth)]. 20154568208
[diabetic encephalopathy]. 20154555153
[competition of renal effects of angiotensin ii and extracellular fluid volume receptors]. 20154330959
[irreversible lesions of the trigeminal nerve caused by chlorinated acetylenes in two patients]. 20154314203
structure and sequence analyses of bacteroides proteins bvu_4064 and bf1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions.n-terminal domains of bvu_4064 and bf1687 proteins from bacteroides vulgatus and bacteroides fragilis respectively are members of the pfam family pf12985 (duf3869). proteins containing a domain from this family can be found in most bacteroides species and, in large numbers, in all human gut microbiome samples. both bvu_4064 and bf1687 proteins have a consensus lipobox motif implying they are anchored to the membrane, but their functions are otherwise unknown. the c-terminal half of bvu_4064 is a ...201525592227
[x-ray radioisotope diagnosis of tumor metastases of urogenital organs into the skeleton]. 20155063119
dialysis of poisons and drugs - annual review. 20154610970
[apparatus for automatic reinfusion of blood]. 20154720164
three hippies--a study of a late-adolescent identity formation. 20154476728
[metal chelates of a bispyridyl-tetrahydrothiazine dioxide]. 20154663589
[hand burns caused by a laundry press]. 20154552000
the use of the xenopus oocyte to prove the existence of messenger sequences in high molecular weight rna. 20154512958
[the urinary excretion of lotrimazole in various age groups of children]. 20154762903
[simultaneous acute arterial thromboembolism in the four limbs]. 20154425117
[presidential address. health is harmony]. 20154337670
sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice.rapid shifts in microbial composition frequently occur during intestinal inflammation, but the mechanisms underlying such changes remain elusive. here we demonstrate that an increased caecal sialidase activity is critical in conferring a growth advantage for some bacteria including escherichia coli (e. coli) during intestinal inflammation in mice. this sialidase activity originates among others from bacteroides vulgatus, whose intestinal levels expand after dextran sulphate sodium administration ...201526303108
functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a gpcr g2a/132 agonist.the trillions of bacteria that make up the human microbiome are believed to encode functions that are important to human health; however, little is known about the specific effectors that commensal bacteria use to interact with the human host. functional metagenomics provides a systematic means of surveying commensal dna for genes that encode effector functions. here, we examine 3,000 mb of metagenomic dna cloned from three phenotypically distinct patients for effectors that activate nf-κb, a tr ...201526283367
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