Publications

detection of rickettsia spp. and host and habitat associations of fleas (siphonaptera) in eastern taiwan.	rickettsia typhi and rickettsia felis (rickettsiales: rickettsiaceae) are two rickettsiae principally transmitted by fleas, but the detection of either pathogen has rarely been attempted in taiwan. of 2048 small mammals trapped in eastern taiwan, apodemus agrarius pallas (24.5%) and mus caroli bonhote (24.4%) (both: rodentia: muridae) were the most abundant, and m. caroli hosted the highest proportion of fleas (63.9% of 330 fleas). two flea species were identified: stivalius aporus jordan and ro ...	2012	22390200
murine typhus and leptospirosis presenting with undifferentiated symptoms of an acute febrile illness to waikato hospital, new zealand, 2009-2010.	this prospective observational study aimed to identify what proportion of patients presenting to waikato hospital with undifferentiated symptoms of an acute febrile illness (usfi) have leptospirosis or murine typhus infection, and to identify factors at presentation predictive of each infection. it also aimed to identify infecting rickettsial organism(s) causing murine typhus in the region.	2013	23799383
serological evidence for exposure of dogs to rickettsia conorii, rickettsia typhi, and orientia tsutsugamushi in sri lanka.	vector-borne rickettsial infection is a major cause of febrile illnesses throughout the world. although vertebrates hosting the vectors play a vital role in the natural cycle of rickettsiae, studies have not been conducted on them in sri lanka. therefore, the present study was designed to determine the exposure of dog population in rajawatta, thambavita, and areas of the western slopes and unawatuna of sri lanka to rickettsial pathogens. a total of 123 dog blood samples were collected from those ...	2013	23930973
rickettsioses in the central hills of sri lanka: serological evidence of increasing burden of spotted fever group.	to study the epidemiology, clinical features, and changing pattern of rickettsial infections on the western slopes of the hilly central province of sri lanka over 6 years.	2013	23871280
molecular detection of rickettsia typhi in cats and fleas.	rickettsiatyphi is the etiological agent of murine typhus (mt), a disease transmitted by two cycles: rat-flea-rat, and peridomestic cycle. murine typhus is often misdiagnosed and underreported. a correct diagnosis is important because mt can cause severe illness and death. our previous seroprevalence results pointed to presence of human r. typhi infection in our region; however, no clinical case has been reported. although cats have been related to mt, no naturally infected cat has been describe ...	2013	23940746
murine typhus in humans, yucatan, mexico.		2013	23735173
murine typhus in tunisia: a neglected cause of fever as a single symptom.	we had for aim to describe the epidemiologic and clinic characteristics of murine typhus in a series of 43 serologically confirmed cases, in our region.	2013	23619288
flea-borne rickettsioses in the north of caldas province, colombia.	rickettsia typhi and r. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. in 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of caldas, colombia. we now report the specific seroprevalence against r. typhi and r. felis, and associated risk ...	2013	23473218
rats, cities, people, and pathogens: a systematic review and narrative synthesis of literature regarding the ecology of rat-associated zoonoses in urban centers.	urban norway and black rats (rattus norvegicus and rattus rattus) are the source of a number of pathogens responsible for significant human morbidity and mortality in cities around the world. these pathogens include zoonotic bacteria (leptospira interrogans, yersina pestis, rickettsia typhi, bartonella spp., streptobacillus moniliformis), viruses (seoul hantavirus), and parasites (angiostrongylus cantonensis). a more complete understanding of the ecology of these pathogens in people and rats is ...	2013	23590323
molecular detection of rickettsia felis and candidatus rickettsia asemboensis in fleas from human habitats, asembo, kenya.	the flea-borne rickettsioses murine typhus (rickettsia typhi) and flea-borne spotted fever (fbsf) (rickettsia felis) are febrile diseases distributed among humans worldwide. murine typhus has been known to be endemic to kenya since the 1950s, but fbsf was only recently documented in northeastern (2010) and western (2012) kenya. to characterize the potential exposure of humans in kenya to flea-borne rickettsioses, a total of 330 fleas (134 pools) including 5 species (xenopsylla cheopis, ctenoceph ...	2013	23675818
multispacer typing of rickettsia isolates from humans and ticks in tunisia revealing new genotypes.	rickettsioses are important remerging vector born infections. in tunisia, many species have been described in humans and vectors. genotyping is important for tracking pathogen movement between hosts and vectors. in this study, we characterized rickettsia species detected in patients and vectors using multispacer typing (mst), proposed by founier et al. and based on three intergenic spacers (dksa-xerc, rmpe- trna(fmet), mppa-pruc) sequencing.	2013	24380581
rickettsia typhi possesses phospholipase a2 enzymes that are involved in infection of host cells.	the long-standing proposal that phospholipase a2 (pla2) enzymes are involved in rickettsial infection of host cells has been given support by the recent characterization of a patatin phospholipase (pat2) with pla2 activity from the pathogens rickettsia prowazekii and r. typhi. however, pat2 is not encoded in all rickettsia genomes; yet another uncharacterized patatin (pat1) is indeed ubiquitous. here, evolutionary analysis of both patatins across 46 rickettsia genomes revealed 1) pat1 and pat2 l ...	2013	23818842
whole-proteome analysis of twelve species of alphaproteobacteria links four pathogens.	thousands of whole-genome and whole-proteome sequences have been made available through advances in sequencing technology, and sequences of millions more organisms will become available in the coming years. this wealth of genetic information will provide numerous opportunities to enhance our understanding of these organisms including a greater understanding of relationships among species. researchers have used 16s rrna and other gene sequences to study the evolutionary origins of bacteria, but t ...	2013	25437336
[management of alcoholism, drug intoxication, and attempted suicide].		2013	3845138
isograft and allograft control studies for murine cardiac transplantation.		2013	3547848
[cardiovascular disorder syndrome in sepsis].	the authors have observed 126 patients with sepsis and made a conclusion that all of them had cardio-vascular insufficiency. the use of hyperbaric oxygenation resulted in better activity of the cardio-vascular system.	2013	3798658
preferences, attitudes and personality as determinants of salt intake.	thirty-six female subjects took part in a study involving using pre-weighed table and cooking salt pots, along with complete urine collections for 7 days. urinary sodium excretion was determined, and was used as an estimate of sodium (salt) intake. other measures taken were, most preferred concentration of salt in soup, blood pressure, body weight and height, along with questionnaires on general food preferences, attitudes to adding table salt to foods, and the eysenck personality inventory (epi ...	2013	3771282
a glance through time.		2013	3822374
meperidine disposition in burn patients.	limited information is available describing the pharmacokinetics of hepatically-cleared drugs in burn patients. based on the hypothesis that after burn injury, plasma meperidine clearance should increase in response to the postburn increase in hepatic blood flow, we examined the kinetics of intravenous meperidine in eleven patients about one week after burn injury (acute study) and in five of these patients about six weeks postburn (convalescent study). the meperidine steady-state distribution v ...	2013	3797808
orchidectomy alone for clinical stage i non-seminomas.		2013	3832104
[saturnism caused by skin absorption of a drug].	a case of chronic lead poisoning is described in a woman presenting with abdominal pain due to cutaneous absorption of a lead soap. we have found no other case of intoxication by this route in the literature.	2013	3738459
modulation of fluoropyrimidine metabolism by chlorpromazine.	chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into rna of several fluoropyrimidine drugs. using s-180 murine sarcoma cells, the accumulation of the base fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as measured by hplc. in contrast, the accumulation and metabolism of the nucleoside fluorouridine was suppressed by chlorpromazine. cytotoxicity studies revealed that non-toxic concentrati ...	2013	3741420
[regulation of blood coagulation by heparin and related proteins].		2013	3694818
[aseptic meningitis after treatment with ibuprofen].		2013	3669815
lung cancer: is fluoride in cigarette smoke an etiological factor?		2013	3636579
medial impingement lesions of the tibial plafond.	this paper presents a newly recognized post-traumatic lesion of the ankle resulting from the impingement of the medial aspect of the talar dome against the adjacent area of the tibial plafond secondary to dorsiflexory and plantarflexory inversion injuries. subsequently, a transchondral fracture is produced, resulting in a medial impingement lesion. this lesion is usually associated with ankle trauma, such as lateral ankle sprains, ruptures of the fibular collateral ligaments, and transchondral f ...	2013	3559041
[the function of the bronchi draining healed caverns].		2013	3960845
ultrastructure of the squid axon membrane as revealed by freeze-fracture electron microscopy.	the structure of the axolemma of the squid giant axon was studied by freeze-fracture electron microscopy. three types of preparations were examined: intact axons, axons with their schwann cell sheaths stripped off prior to freezing, and axons with their schwann cell sheaths chemically detached but not mechanically removed. because of a problem of cross-fracturing, the first two types of preparations revealed very few membrane faces of the axolemma. this cross-fracturing problem, however, was eli ...	2013	3719619
[inoculability and threshold effects in transplantation of experimental tumors].	inoculability of various experimental tumors (spontaneous, chemically-induced, solid, ascitic and leukemic) versus the amount of inoculated tumor cells (10(0)-10(7)) was studied. with small amounts of cells (10(2)-10(3)), inoculability of some tumors appeared to be nil, while in certain long-passaged neoplasms, particularly, leukemia, as few as 5-10 cells were enough. the data obtained pointed to a threshold in experimental tumor transplantation. however, quantitative analysis failed to establis ...	2013	3630035
"evaluable" vs "evaluatable": a postscript.		2013	3597684
one hundred fifty cases of cardiac arrhythmias treated with acta practolol (i.c.i. 50.172).		2013	4147612
one hundred fifty cases of cardiac arrhythmias treated with acta practolol (i.c.i. 50.172).		2013	4147612
management team assessment: a learning style inventory.		2013	3634254
ophthalmic manifestations of pulmonary diseases.	patients suffering from pulmonary diseases often have ophthalmic manifestations, some of which may be critical and disabling. the purpose of this article is to discuss the ophthalmologic manifestations of pulmonary diseases. this is achieved by describing a typical ophthalmologic examination, starting with the external structures and ocular adnexae and proceeding through the structures of the eye, including the retina, optic nerve, and orbit.	2013	3621876
[development and improvement of hospital records. a program of the panamerican health organization].		2013	4235700
the hp, gc, gm, km and beta 2-glycoprotein i genetic variants in hairy cell leukemia: no apparent association.	no significant differences could be observed when hp, gc, gm, km and beta 2-glycoprotein i phenotypes of 50 patients with hairy cell leukemia were compared with healthy unrelated adults.	2013	3923375
[indirect estimation of the maximal aerobic power of a male and female population from brussels aged 6 to 23 years. comparison with a direct technic for measuring maximal oxygen consumption].	validation of the maximal multistage 20 m shuttle run test with 1 min steps has been compared with a stepwise load increase on a bicycle ergometer among 201 male and female subjects ranging from 14 to 30 years. a slight underestimation of vo2 max (5.2%) amounting to 2.71 ml . min-1 . kg-1 was observed for the multistage shuttle test as compared to the bicycle test (r = 0.72). the analysis of the biological values collected after exercise does not show major differences between the two tests (pla ...	2013	3795116
the effects of general anesthesia on upper respiratory tract infections in children.	a prospective cohort study of 489 pediatric patients was performed to investigate the prevalence of perioperative respiratory complications and symptomatology in children presenting for myringotomy with upper respiratory tract infections (uris). all children undergoing myringotomy received halothane n2o/o2 anesthesia administered via face mask. information on complications and respiratory symptoms was obtained from the anesthesia and recovery room records, and by standardized questionnaire. ther ...	2013	3688537
perceived continuity of gliding and steady-state tones through interrupting noise.		2013	3696942
reaction of helenalin with hydrogen chloride.		2013	4712638
reaction of helenalin with hydrogen chloride.		2013	4712638
[early prognosis of intracranial hemorrhage in premature infants].	between july 1979 and june 1984 an intracerebral haemorrhage developed in 87 premature infants (mean gestational age 29.5 weeks, mean birth weight 1156g). 46 of these died, 41 infants survived. their psychomotoric development was followed up to a mean age of 19 months. in 63% of the patients the haemorrhage occurred during the first four days of life. its frequency was highest in premature infants of 27 to 30 weeks of gestation. the survival rate was influenced by the gestational age and by the ...	2013	3748036
[volvulus caused by massive intestinal ascariasis].		2013	3986032
staging of malignant lymphoma by laparotomy and splenectomy: review of the literature.		2014	4624308
interactions of endotoxin with cortisol and acute phase proteins in septic shock neonates.	crp, alpha 1-acid glycoprotein and haptoglobin were studied in 13 septic shock neonates. endotoxin was recovered from eight infants. serum cortisol concentration from infants with endotoxemia (917 +/- 596 ng/ml) was significantly higher than that from infants without endotoxemia (398 +/- 239 ng/ml). serum cortisol correlated well with immature neutrophil counts defined as the unit "band/neutrophil". increased cortisol level and immature neutrophil counts preceded the elevation of crp, alpha 1-ac ...	2014	3953280
cerebral infarct after an overdose of anti-cold medicines.		2014	3952585
verbal recall in schizophrenia: differential effect of retroactive interference in nonparanoid patients.		2014	3987245
copper and inflammation--a possible rationale for the pharmacological manipulation of inflammatory disorders.	acute and chronic inflammations are characterized, among other features, by changes in the metabolism of copper and by a widespread responsiveness to the therapy with copper-containing molecules. the exact map of inflammation-induced copper movements as well as the role played by the metal in the pathogenesis of inflammatory disorders are, however, far from being clear, and this is especially true in the case of chronic processes. nevertheless the present knowledge suggests that the "copper appr ...	2014	3907313
restoration of missing or misplaced canines.	restorative treatments for canines were discussed to correct three clinical abnormalities: (1) fully erupted permanent canine in the lateral incisor position, (2) missing permanent canines, and (3) partially exposed canines in normal arch position. the primary concerns are the development of esthetics, anterior guidance, and adequate support for fixed restorations.	2014	3891977
[ultrasonic angiography in the diagnosis of lesions of the brachiocephalic branches of the aorta].	a review of combined ultrasonic data in a group of normal subjects and in 20 patients with occlusive brachiocephalic aortic lesions has demonstrated that combined use of highly-informative ultrasonic techniques, including ultrasonic dopplerography, ultrasonic angiography and spectrum analysis of the doppler echo expands considerably possibilities of the diagnosis of occlusive lesions and enables quantitative assessment of regional hemodynamic disorders.	2014	3910909
the mechanism of a steroidal aromatization reaction.		2014	4251998
major groove or minor groove?		2014	3960114
intraoperative autologous transfusion.	intraoperative autologous transfusion is a technique that was first used almost 2 centuries ago but that has realized its potential only in the past 5 years. a growing national awareness of transfusion-related morbidity, of the need for alternative blood sources, and of improved methods for red blood cell recovery has led to an increased frequency of use of autologous transfusion. most hospital programs use semicontinuous flow centrifugation or canister technology for the intraoperative salvage ...	2014	3919219
ultrastructure of als transformed lymphocytes.		2014	4238995
a simplified procedure for serum butanol-extractable iodine.		2014	4169373
[possible and actual trends in the evolution of invertebrates].		2014	4155564
[preventive health care policy. opening contribution in the panel discussion on the physicians' meeting in odense, september 13th, 1974].		2014	4155544
suturing for nurses.		2014	4111177
evaluation of thyroid function.		2014	4111176
instructional material centers for handicapped children.		2014	4111165
[prostatic adenoms. instrumental and surgical therapy].		2014	4138832
131-i treatment for thyrotoxicosis.		2014	4098074
determination of adriamycin and its fluorescent metabolites in biological fluids of inpatients with lung cancer by high performance liquid chromatography.		2014	4092285
the baseball strike and plastic surgery.		2014	3945691
[bone marrow transplantation in children. iii. infection and infection-specific immunity].		2014	3937409
low molecular weight heparin in hemodialysis and hemofiltration patients.	low molecular weight (lmw)-heparin was used as the sole anticoagulant during hemodialysis and hemofiltration in a pilot study on 32 patients. a lmw-heparin dose corresponding to 50% of the patients usual unfractionated, standard (uf)-heparin dose was found to produce comparable plasma heparin levels (anti-fxa-activity). no thrombosis of the extracorporal system and no bleeding complications occurred at this lmw-heparin dose. in contrast to uf-heparin, lmw-heparin produced only slight increases i ...	2014	3936965
[abnormalities of the hypothalamo-pituitary axis in addison's disease--a case report].		2014	3923154
preoperative assessment of high-risk surgical patients.	from the foregoing accounts of preoperative assessment of myocardial performance, as well as preload and afterload status it is clear that the proper anesthesia techniques and agents can be selected. physiologically optimal adjustments of preload, afterload, and myocardial function can be attained by the appropriate, harmonious selection of anesthesia technique and vasoactive drugs made on the basis of close hemodynamic monitoring preoperatively, intraoperatively, and in the immediate postoperat ...	2014	3901344
effect of colchicine on atherosclerosis. iii. study of dermal elastic fibers by quantitative histochemistry, automated image analysis.	computerized automatic-image analytical procedure was applied on dermal biopsies stained for elastin by a new procedure giving a completely white background and staining only the elastic fiber system. in arteriosclerotic hypertensive patients, a 3-4 months' treatment with 1 mg colchicine per day resulted in a significant (60-80%, p less than 0.01) increase of the dermal elastic fiber density both in the superficial papillary dermis and in the deep dermis. this result shows that the age-dependent ...	2014	3902321
children in the extremes of physical and psychological measurements.		2014	4186946
thyroid carcinoma metastatic to pituitary.		2014	4032051
[continuous measurement of oxygen consumption and carbon dioxide production during abdominal aortic surgery].		2014	3938818
injury to the glenoid fossa.	an illustrated case of fracture through the confines of the glenoid fossa by the mandibular condyle is presented. the mechanism of injury and postinjury sequelae of this rarely reported but frequently suspected occurrence are discussed and a treatment rationale proposed. the key to the diagnosis of this entity is an awareness of vector forces directed to the region of the glenoid fossa with or without evidence of subcondylar fracture.	2014	3945692
[a caries index of therapeutic value].		2014	4155565
[interactions between pregnancy and diabetes].		2014	3911462
myositis in a child with murine typhus.	a 12-year-old boy presented with fever, lower extremity pain and weakness. examination revealed paraparesis, thigh and calf tenderness. labs showed high creatinine phosphokinase and rickettsia typhi titers. this case illustrates endemic typhus should be considered in the differential diagnosis of myositis especially in areas with high prevalence of the disease. to our knowledge, this is the first reported case of myositis and paraparesis associated with a case of murine typhus.	2014	24757508
loop-mediated isothermal amplification for rickettsia typhi (the causal agent of murine typhus): problems with diagnosis at the limit of detection.	murine typhus is a flea-borne disease of worldwide distribution caused by rickettsia typhi. although treatment with tetracycline antibiotics is effective, treatment is often misguided or delayed due to diagnostic difficulties. as the gold standard immunofluorescence assay is imperfect, we aimed to develop and evaluate a loop-mediated isothermal amplification (lamp) assay. lamp assays have the potential to fulfill the who assured criteria (affordable, sensitive, specific, user friendly, robust an ...	2014	24371248
rickettsial infections in southeast asia: implications for local populace and febrile returned travelers.	rickettsial infections represent a major cause of non-malarial febrile illnesses among the residents of southeast asia and returned travelers from that region. there are several challenges in recognition, diagnosis, and management of rickettsioses endemic to southeast asia. this review focuses on the prevalent rickettsial infections, namely, murine typhus (rickettsia typhi), scrub typhus (orientia tsutsugamushi), and members of spotted fever group rickettsiae. information on epidemiology and reg ...	2014	24957537
high prevalence of rickettsia typhi and bartonella species in rats and fleas, kisangani, democratic republic of the congo.	the prevalence and identity of rickettsia and bartonella in urban rat and flea populations were evaluated in kisangani, democratic republic of the congo (drc) by molecular tools. an overall prevalence of 17% bartonella species and 13% rickettsia typhi, the agent of murine typhus, was found in the cosmopolitan rat species, rattus rattus and rattus norvegicus that were infested by a majority of xenopsylla cheopis fleas. bartonella queenslandensis, bartonella elizabethae, and three bartonella genot ...	2014	24445202
murine typhus associated with parinaud's oculoglandular syndrome in 2 children.	an 11-year-old-girl and a 13-year-old-boy presented with characteristic findings of parinaud's oculoglandular syndrome. the girl was initially suspected of having bartonella henselae infection and the boy was initially diagnosed as francisella tularensis infection. both children had laboratory-confirmed infection with rickettsia typhi.	2014	24853542
molecular detection of rickettsia felis and bartonella henselae in dog and cat fleas in central oromia, ethiopia.	fleas are important vectors of several rickettsia and bartonella spp. that cause emerging zoonotic diseases worldwide. in this study, 303 fleas collected from domestic dogs and cats in ethiopia and identified morphologically as ctenocephalides felis felis, c. canis, pulex irritans, and echidnophaga gallinacea were tested for rickettsia and bartonella dna by using molecular methods. rickettsia felis was detected in 21% of fleas, primarily c. felis, with a similar prevalence in fleas from dogs and ...	2014	24445204
murine typhus in elderly patients: a prospective study of 49 patients.	the characteristics of rickettsia typhi infection in elderly patients have not been extensively described in the literature.	2014	25119441
spotted fever from rickettsia typhi in an older woman: a case report from a geographic area where it would not be expected.	we describe the case of a 75-year-old woman presenting with spotted fever followed by acute renal failure and septic shock. the infection was caused by rickettsia typhi, not reported in calabria district (southern italy) since world war ii. the diagnosis of murine typhus was made 3 days after admission and was based solely on clinical criteria when her worsening condition required a prompt move to the intensive care unit. therapy with tigecycline was then started immediately and the patient impr ...	2014	25111740
isolation of rickettsia typhi from human, mexico.		2014	25076014
severe murine typhus with pulmonary system involvement.	we encountered a case of severe murine typhus complicated by acute respiratory distress syndrome. to determine worldwide prevalence of such cases, we reviewed the literature and found that respiratory symptoms occur in ≈30% of murine typhus patients. in disease-endemic areas, murine typhus should be considered for patients with respiratory symptoms and fever.	2014	25062435
phenotype of the anti-rickettsia cd8(+) t cell response suggests cellular correlates of protection for the assessment of novel antigens.	the obligately intracellular bacteria rickettsia infect endothelial cells and cause systemic febrile diseases that are potentially lethal. no vaccines are currently available and current knowledge of the effective immune response is limited. natural and experimental rickettsial infections provide strong and cross-protective cellular immunity if the infected individual survives the acute infection. although resistance to rickettsial infections is attributed to the induction of antigen-specific t ...	2014	25043277
three new species of fleas belonging to the genus macrostylophora from the three-striped ground squirrel, lariscus insignis, in java.	three new species of fleas belonging to the genus macrostylophora (siphonaptera, ceratophyllidae) are described from the three-striped ground squirrel, lariscus insignis, from tjibodas, west java (jawa barat), indonesia at an elevation of 1500 m. macrostylophora larisci sp. n. is described from three male specimens, macrostylophora debilitata sp. n. is described from one male and macrostylophora wilsoni sp. n. is described from one female. non-genital morphological characters of the female speci ...	2014	24810381
[murine typhus in a japanese traveler returning from indonesia: a case report].	we report herein on a 20-year-old japanese man who was referred to our hospital for fever and diarrhea after returning from indonesia. on admission, his blood test was essentially normal, besides a slight elevation in inflammatory markers. after excluding malaria and dengue fever, empiric use of ceftriaxone was initiated for suspected enteric fever, which was unsuccessful. however, drastic clinical improvement was observed after initiation of minocycline. the polymerase chain reaction test for r ...	2014	24783459
murine typhus as a cause of cognitive impairment: case report and a review of the literature.	murine typhus is a systemic febrile illness caused by rickettsia typhi, a gram-negative, obligate intracellular bacterium. it is found worldwide, including in the united states, where cases are concentrated in suburban areas of texas and california. the disease manifests with fever, headache, and rash. central nervous system involvement is rare in both adults and children. aseptic meningitis and meningoencephalitis are the most common neurological presentations, occurring in 2% to 5% of cases. n ...	2014	24321542
serosurvey of rickettsia typhi and rickettsia felis in hiv-infected patients.	consistent with the effects of hiv on cell-mediated immunity, an increased susceptibility to intracellular microorganisms has been observed. rickettsiae are obligate intracellular microorganisms. the aim of this study was to examine rickettsia typhi and rickettsia felis infections in hiv+ population. sera of 341 hiv+ patients were evaluated by indirect immunofluorescent assay. age, sex, residential locality, risk behavior, stage according to criteria of the center for disease control and prevent ...	2014	24467705
pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a fever cohort and a case series analysis.	there is a paucity of published reports on pregnancy outcome following scrub and murine typhus despite these infections being leading causes of undifferentiated fever in asia. this study aimed to relate pregnancy outcome with treatment of typhus.	2014	25412503
serosurveillance of orientia tsutsugamushi and rickettsia typhi in bangladesh.	scrub and murine typhus infections are under-diagnosed causes of febrile illness across the tropics, and it is not known how common they are in bangladesh. we conducted a prospective seroepidemiologic survey across six major teaching hospitals in bangladesh by using an igm enzyme-linked immunosorbent assay. results indicated recent exposure (287 of 1,209, 23.7% seropositive for orientia tsutsugamushi and 805 of 1,209, 66.6% seropositive for rickettsia typhi). seropositive rates were different in ...	2014	25092819
dual exposure of rickettsia typhi and orientia tsutsugamushi in the field-collected rattus rodents from thailand.	field-collected rodents and fleas from ten provinces covering four regions of thailand were investigated for possible rickettsial pathogen infections. the 257 trapped-rodents belonged to 12 species. five species of genus rattus accounted for 93% of the total capture, of which rattus exulans and rattus norvegicus were the two major species caught. all flea specimens, removed from trapped rodents, were identified as xenopsylla cheopis. the pcr technique was performed on ectoparasite specimens to d ...	2014	24820571
detection of rickettsia felis, rickettsia typhi, bartonella species and yersinia pestis in fleas (siphonaptera) from africa.	little is known about the presence/absence and prevalence of rickettsia spp, bartonella spp. and yersinia pestis in domestic and urban flea populations in tropical and subtropical african countries.	2014	25299702
discovery of novel cross-protective rickettsia prowazekii t-cell antigens using a combined reverse vaccinology and in vivo screening approach.	rickettsial agents are some of the most lethal pathogens known to man. among them, rickettsia prowazekii is a select agent with potential use for bioterrorism; yet, there is no anti-rickettsia vaccine commercially available. owing to the obligate intracellular lifestyle of rickettsiae, cd8(+) t cells are indispensable for protective cellular immunity. furthermore, t cells can mediate cross-protective immunity between different pathogenic rickettsia, a finding consistent with the remarkable simil ...	2014	25010827
multimethylation of rickettsia ompb catalyzed by lysine methyltransferases.	methylation of rickettsial ompb (outer membrane protein b) has been implicated in bacterial virulence. rickettsial methyltransferases rp789 and rp027-028 are the first biochemically characterized methyltransferases to catalyze methylation of outer membrane protein (omp). methylation in omp remains poorly understood. using semiquantitative integrated liquid chromatography-tandem mass spectroscopy, we characterize methylation of (i) recombinantly expressed fragments of rickettsia typhi ompb expose ...	2014	24497633
rickettsia infection could be the missing piece of the buerger's disease puzzle.	rickettsia was suggested as a possible etiology of buerger's disease (bd) in the 1980s but this suggestion was never ruled out or proven. recently, we found evidence of rickettsia by polymerase chain reaction in 3 out of 25 biopsy samples from the amputated limb of a young man diagnosed with bd.	2015	26344511
disrupting protein expression with peptide nucleic acids reduces infection by obligate intracellular rickettsia.	peptide nucleic acids (pnas) are single-stranded synthetic nucleic acids with a pseudopeptide backbone in lieu of the phosphodiester linked sugar and phosphate found in traditional oligos. pna designed complementary to the bacterial shine-dalgarno or start codon regions of mrna disrupts translation resulting in the transient reduction in protein expression. this study examines the use of pna technology to interrupt protein expression in obligate intracellular rickettsia sp. their historically in ...	2015	25781160
shell-vial culture and real-time pcr applied to rickettsia typhi and rickettsia felis detection.	murine typhus is a zoonosis transmitted by fleas, whose etiological agent is rickettsia typhi. rickettsia felis infection can produces similar symptoms. both are intracellular microorganisms. therefore, their diagnosis is difficult and their infections can be misdiagnosed. early diagnosis prevents severity and inappropriate treatment regimens. serology can't be applied during the early stages of infection because it requires seroconversion. shell-vial (sv) culture assay is a powerful tool to det ...	2015	26289162
rickettsia and bartonella species in fleas from reunion island.	rickettsia felis, rickettsia typhi, and bartonella dna was detected by molecular tools in 12% of rattus rattus fleas (xenopsylla species) collected from reunion island. one-third of the infested commensal rodents captured during 1 year carried at least one infected flea. as clinical signs of these zoonoses are non-specific, they are often misdiagnosed.	2015	25646263