Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [trench fever]. | 1999 | 10201203 | |
| expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. | inducible nitric oxide synthase (inos) is required in immune response against infections and is involved in granuloma formation in animals; in murine macrophages, inos is induced by lipopolysaccharide and interferon-gamma. in contrast, the role of inos in human immune response against infections is still questioned, and its expression in granulomas is poorly investigated. using western blotting and immunohistochemistry, we investigated inos expression in human lymph nodes with nonspecific reacti ... | 1999 | 9916929 |
| cat-scratch disease. | 1999 | 9917765 | |
| management of b. henselae neuroretinitis in cat-scratch disease. | 1999 | 9917766 | |
| bartonella henselae infection associated with peripapillary angioma, branch retinal artery occlusion, and severe vision loss. | to report atypical clinical features of bartonella henselae neuroretinitis treated with combination antibiotics. | 1999 | 10030575 |
| culture-positive bartonella quintana endocarditis. | a 50-year-old alcoholic man with a 1-year history of pyrexia of unknown origin was admitted with symptoms of endocarditis. large vegetations on his mitral and aortic valve were found on echocardiography. using the bactec 9240 system. bartonella quintana could be grown from two culture sets of blood collected before the start of antimicrobial therapy. this is the first case report of culture-proven bartonella infection in the uk. and is noteworthy because bartonella quintana was detected in conve ... | 1999 | 10219581 |
| [cat-scratch disease: series of 14 cases. the diagnostic usefulness of serology]. | disease by cat scratch (csd) is a syndrome characterized by regional adenopathies following cat scratch or bite. despite knowing the etiologic agent of the same, there is still controversy in the diagnosis of the syndrome in daily clinical practice. | 1999 | 10069107 |
| [three children with systemic cat scratch disease]. | three girls with systemic cat scratch disease, aged 10, 13 and 9 years, were reported. they presented a prolonged fever and back pain in the early stage of the disease, and had no regional lymphadenopathy. two of them had hepatosplenic granulomas, one with multiple 5 mm hypoechoic lesions in the liver and spleen, and the other with a single 2.5 cm hypodense lesion in the left hepatic lobe. the latter patient underwent a partial left hepatic lobectomy. all patients had elevated titers of antibodi ... | 1999 | 10222672 |
| disseminated bartonella infection with granulomatous hepatitis in a liver transplant recipient. | disseminated infection with bartonella spp with granulomatous hepatitis was diagnosed in a liver transplant recipient presenting with fever of unknown origin. pathological findings on liver biopsy were atypical, with scant granulomas seen only after a second biopsy. the patient responded promptly to antibiotic therapy. infections caused by bartonella spp should be considered in transplant recipients with fever of unknown origin. | 1999 | 10226118 |
| cat-scratch disease encephalopathy: a cause of status epilepticus in school-aged children. | we describe 6 school-aged patients who presented with status epilepticus (se) secondary to cat-scratch disease (csd) encephalopathy to alert clinicians to this distinctive clinical entity. the hospital database for admissions during 1 year was reviewed for patients presenting with se; 4 of 5 previously healthy school-aged children with se had csd encephalopathy based on elevated indirect fluorescent antibody titers to bartonella henselae. csd encephalopathy should be included in the differential ... | 1999 | 10228301 |
| serologic response to bartonella henselae in patients with cat scratch disease and in sick and healthy children. | indirect fluorescent antibody assay (ifa) is the most reliable test for detecting antibody to bartonella henselae in the diagnosis of cat scratch disease (csd). recently, an elisa test has been proposed, but conflicting results are reported. we compared igg-ifa and igg-igm elisa methods in csd patients and in healthy children. we also tested elisa specificity in a large group of healthy controls and in children with lymphoma-associated lymphadenopathy and with pyogenic lymphadenitis. the elisa p ... | 1999 | 10229038 |
| experimental infection of cotton rats with three naturally occurring bartonella species. | the kinetics of infection and humoral immune response of laboratory-bred cotton rats (sigmodon hispidus) challenged with three bartonella spp. recovered from the blood of naturally infected cotton rats captured in georgia (usa) are described. bartonella spp. infection, as determined by bacteremia, occurred in all 18 cotton rats inoculated with live bartonella of each species at either a low dose, 10(3) colony-forming units (cfu's), or high dose, 10(7) cfu. cotton rats inoculated with lower doses ... | 1999 | 10231754 |
| detection and identification of ehrlichia, borrelia burgdorferi sensu lato, and bartonella species in dutch ixodes ricinus ticks. | a sensitive and specific pcr hybridization assay was developed for the simultaneous detection and identification of ehrlichia and borrelia burgdorferi sensu lato. in separate assays the 16s rrna gene of ehrlichia species and the 23s-5s rrna spacer region of b. burgdorferi sensu lato were amplified and labeled by pcr. these pcr products were used in a reverse line blot hybridization assay in which oligonucleotide probes are covalently linked to a membrane in parallel lines. hybridization of the s ... | 1999 | 10364588 |
| culture of bartonella quintana and bartonella henselae from human samples: a 5-year experience (1993 to 1998). | bartonella quintana and bartonella henselae are fastidious gram-negative bacteria responsible for bacillary angiomatosis, trench fever, cat scratch disease, and endocarditis. during a 5-year period, we received 2,043 samples for culture of bartonella sp. we found bartonella sp. to be the etiologic agent in 38 cases of endocarditis, 78 cases of cat scratch disease, 16 cases of bacteremia in homeless people, and 7 cases of bacillary angiomatosis. we correlated the results of positive cultures with ... | 1999 | 10325344 |
| cat-scratch disease simulating a malignant process of the chest wall. | cat-scratch disease is a well-known cause of regional adenopathy in immunocompetent children. rarely, patients may present with symptoms simulating a neoplastic disease. the case of a 12-year-old boy with fever, swelling of the chest wall and hepatosplenic nodules is reported. histological analysis of biopsy specimen obtained from the chest wall lesion and the liver revealed granulomatous reaction without malignant cells. serological investigations were positive for bartonella species. the sympt ... | 1999 | 10333124 |
| acute clinical disease in cats following infection with a pathogenic strain of bartonella henselae (lsu16). | bartonella henselae is the causative agent of human cat scratch disease as well as several serious sequelae of infections, including bacillary angiomatosis and bacillary peliosis. conflicting reports describe the pathogenesis of b. henselae in the cat. in this study, we characterized a strain of b. henselae termed lsu16. this strain was isolated on rabbit blood agar from a naturally infected 10-month-old female cat during a recurrent episode of bacteremia. the bacterial species was confirmed by ... | 1999 | 10338522 |
| presumed ocular bartonellosis. | the spectrum of diseases caused by bartonella henselae continues to expand and ocular involvement during this infection is being diagnosed with increasing frequency. | 1999 | 10365031 |
| an outbreak of acute bartonellosis (oroya fever) in the urubamba region of peru, 1998. | during may 1998, we conducted a case-control study of 357 participants from 60 households during an outbreak of acute bartonellosis in the urubamba valley, peru, a region not previously considered endemic for this disease. blood and insect specimens were collected and environmental assessments were done. case-patients (n = 22) were defined by fever, anemia, and intra-erythrocytic coccobacilli seen in thin smears. most case-patients were children (median age = 6.5 years). case-patients more frequ ... | 1999 | 10463692 |
| the mutt motif family of nucleotide phosphohydrolases in man and human pathogens (review). | human cells express at least eight members of the mutt motif protein (or nudix hydrolase) family. these enzymes are believed to eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signalling nucleotides and their metabolites. six have been fully or partially characterized: i) hmth1 is a nucleoside triphosphatase which restricts at-->cg transversions by specifically degrading the oxidized nucleotide 8-oxo-dgtp; ii) hapah1 preferentially degrades the signallin ... | 1999 | 10373642 |
| conservative management of documented neuroretinitis in cat scratch disease associated with bartonella henselae infection. | bartonella henselae has been identified as the causative agent of the neuroretinitis associated with cat scratch disease (csd). immunofluorescent antibody tests with good sensitivity and specificity are available to aid in diagnosis. despite diagnostic advances, optimal management remains controversial. we present a case of documented b. henselae macular neuroretinitis managed without antibiotics and discuss antibiotic use in this condition. | 1999 | 10379716 |
| diagnosis of rickettsial diseases using samples dried on blotting paper. | the use of filter paper is an inexpensive and convenient method for collecting, storing, and transporting blood samples for serological studies. in addition, samples occupy little space and can be readily transported without refrigeration. rickettsial diseases often evolve according to an epidemic mode and are now considered reemerging diseases, especially in developing countries, under conditions where fieldwork could be difficult. the suitability of collecting whole-blood specimens on filter p ... | 1999 | 10391847 |
| a case of cat scratch disease masquerading as lymphogranuloma venereum. | 1999 | 10361925 | |
| identification of bartonella-specific immunodominant antigens recognized by the feline humoral immune system. | the seroreactivities of both naturally and experimentally infected cats to bartonella henselae was examined. serum samples collected weekly from nine cats experimentally infected with b. henselae lsu16 were tested by enzyme-linked immunosorbent assay (elisa) and western blot analysis. the magnitude and isotype of the antibody response were investigated by elisa. western blot analysis allowed the identification of at least 24 bartonella-specific antigens recognized by the cats during infection. a ... | 1999 | 10391863 |
| infected dog and cat bites. | 1999 | 10366326 | |
| [infection and angiomatous cutaneous lesions]. | the occurrence of angiomatous cutaneous lesions in the presence of an infective process is not a frequent phenomenon. most infectious diseases are associated with an exanthematous reaction. the combination of an infective illness and angiomatous lesions is seen essentially in the bartonelloses and in kaposi's disease. bartonelloses: group of infections due to alpha-proteobacteria such as bartonella. bartonella bacilliformis (bb), is the causal agent of carrion's disease, the chronic cutaneous fo ... | 1999 | 10399647 |
| systemic bartonella henselae infection with hepatosplenic involvement. | systemic manifestations of bartonella henselae infection are rare in the immunocompetent host. the infection generally has initial symptoms of prolonged fever and multiple granulomatous lesions in liver and spleen. | 1999 | 10400104 |
| radiological case of the month. atypical cat-scratch disease. | 1999 | 10401812 | |
| bone pain after lymphadenitis. bartonella henselae granulomatous osteitis. | 1999 | 10048617 | |
| use of polymerase chain reaction for citrate synthase gene to diagnose bartonella quintana endocarditis. | we describe aortic valve endocarditis caused by bartonella quintana in a 31-year-old man. the diagnosis was made on the basis of polymerase chain reaction amplification of the b quintana citrate synthase gene from cardiac valve tissue, the compatibility of histochemical stains of cardiac valve tissue, and serologic studies. | 1999 | 10396283 |
| changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. | over the past 3 decades, considerable changes have occurred in the types of bacteria causing infection in febrile patients with neutropenia and cancer. twenty years ago, gram-negative bacteria caused approximately 70% of bloodstream infections. as a probable consequence of long-dwelling intravascular devices, fluoroquinolone prophylaxis, and high-dose chemotherapy-induced mucositis, there has been a shift toward gram-positive coccal bacteremia. in most centers today, approximately 70% of bactere ... | 1999 | 10530434 |
| microbes and sequestered substances as mechanisms for disease: bartonella and l-forms as common global etiological agents. | the pathogenicity of microbes may be determined by substances sequestered from blood and bound to their constituent lipid. the brain may not perceive substances sequestered by microbes, to interfere with control to maintain normal levels. pathological conditions can be induced as organisms exposed to antimicrobial substances/conditions and/or deprived of nutrients essential to cell wall synthesis, disintegrate to free lipid-bound compounds and produce l-forms that can deplete nutrients as they r ... | 1999 | 10465665 |
| isolation of a new subspecies, bartonella vinsonii subsp. arupensis, from a cattle rancher: identity with isolates found in conjunction with borrelia burgdorferi and babesia microti among naturally infected mice. | bacteremia with fever due to a novel subspecies of bartonella vinsonii was found in a cattle rancher. the subspecies shared major characteristics of the genus bartonella in terms of most biochemical features and cellular fatty acid profile, but it was distinguishable from other subspecies of b. vinsonii by good growth on heart infusion agar supplemented with x factor and by its pattern of enzymatic hydrolysis of peptide substrates. dna relatedness studies verified that the isolate belonged to th ... | 1999 | 10405408 |
| [two cases of suspected bartonella henselae infection from a dog]. | a 55-year-old male was admitted to our hospital because of fever and left submaxillary, right axillary, and left inguinal lymphadenopathy. a presumptive diagnosis of rickettsiosis was made and treatment with oral doxycycline was started. lymphadenopathy was partialy resolved after antibiotics treatment. ablation of the left inguinal node was done and histopathological examination showed non-hodgkin's lymphoma. lymphadenopathy was resolved by chemotherapy. the second patient, a 40-year-old male, ... | 1999 | 10535269 |
| evaluation of intraspecies genetic variation within the 60 kda heat-shock protein gene (groel) of bartonella species. | a phylogenetic investigation was done on the members of the genus bartonella, based on the dna sequence analysis of the groel gene, which encodes the 60 kda heat-shock protein groel. nucleotide sequence data were determined for a near full-length fragment (1368 bp) of the groel gene of the established bartonella species and used to infer intraspecies phylogenetic relationships. phylogenetic trees were inferred from multiple sequence alignments by using both distance and parsimony methods, which ... | 1999 | 10425758 |
| demonstration of bartonella grahamii dna in ocular fluids of a patient with neuroretinitis. | we describe the clinical and laboratory features of a 55-year-old human immunodeficiency virus-negative female patient who presented with bilateral intraocular inflammatory disease (neuroretinitis type) and behavioral changes caused by a bartonella grahamii infection. diagnosis was based on the pcr analysis of dna extracted from the intraocular fluids. dna analysis of the pcr product revealed a 100% identity with the 16s rrna gene sequence of b. grahamii. the patient was successfully treated wit ... | 1999 | 10565926 |
| development of a system for genetic manipulation of bartonella bacilliformis. | lack of a system for site-specific genetic manipulation has severely hindered studies on the molecular biology of all bartonella species. we report the first site-specific mutagenesis and complementation for a bartonella species. a highly transformable strain of b. bacilliformis, termed jb584, was isolated and found to exhibit a significant increase in transformation efficiency with the broad-host-range plasmid pbbr1mcs-2, relative to wild-type strains. restriction analyses of genomic preparatio ... | 1999 | 10427032 |
| [hepatic and splenic micro-abscess in cat scratch disease. report of a case]. | cat-scratch disease (csd) is an infection caused by a gram-negative bacillus known as bartonella henselae. hepatosplenic disease occurs in only 0.3-0.7% of patients. in this report we describe a 7-year-old male presented with a 4-week history of fever, after diagnosis of csd with regional lymphoadenitis. ultrasonography and tomography identified hepatic and splenic abscesses. antibiotic treatment for three months was associated with resolution of lesions. in patients affected by csd, ultrasonogr ... | 1999 | 10570789 |
| in vitro susceptibilities of four bartonella bacilliformis strains to 30 antibiotic compounds. | we have evaluated for the first time in vitro antibiotic susceptibilities of four human strains of bartonella bacilliformis, the agent of carrion's disease. our results show that b. bacilliformis, like other bartonella species, is highly susceptible to antibiotics, including most beta-lactams, aminoglycosides, chloramphenicol, rifampin, macrolides, tetracyclines, cotrimoxazole, and fluoroquinolones. | 1999 | 10428946 |
| atypical mass lesion associated with cat-scratch disease. | 1999 | 10433602 | |
| seroprevalence of bartonella henselae in cats in germany. | bartonella henselae and b. quintana infections in man are associated with various clinical manifestations including cat-scratch disease, bacillary angiomatosis and bacteraemia. while cats are the natural reservoir for b. henselae, the source of b. quintana is unclear. in this study, the sera of 713 cats from germany were examined for the presence of antibodies against b. henselae, b. quintana or afipia felis by an indirect immunofluorescence assay (ifa). bartonella-specific antibody titres of > ... | 1999 | 10482296 |
| cat scratch disease: posterior segment manifestations. | to evaluate the posterior segment findings seen in ocular cat scratch disease. | 1999 | 10442903 |
| characterization of bartonella henselae-specific immunity in balb/c mice. | balb/c mice were inoculated with bartonella henselae by both systemic and mucosal routes. culture analysis of tissues from mice infected intraperitoneally with a high dose of b. henselae yielded positive results 24 hr after infection. however, culture analysis of blood taken between 6 hr and 7 days after infection from groups receiving live b. henselae were negative. following intraperitoneal infection, b. henselae was detected by polymerase chain reaction in liver and mesenteric lymph nodes by ... | 1999 | 10447753 |
| bartonella henselae associated with parinaud's oculoglandular syndrome. | bartonella henselae was recovered from the conjunctival scraping of a 38-year-old woman who presented with a 2-week history of tender preauricular lymphadenopathy and a 1-day history of a red left eye. dry adherent colonies were observed on agar plates at 21 days of incubation, and the isolate was identified through conventional and molecular tests. polymerase chain reaction (pcr) amplification of a specific region of the 16s rrna gene and confirmation by a separate pcr reaction with hybridizati ... | 1999 | 10452652 |
| an ulcerated nodule associated with lymphadenopathy. | 1999 | 10456353 | |
| bilateral bartonella-associated neuroretinitis. | 1999 | 10458308 | |
| cat scratch encephalopathy. | cat scratch disease is usually a self-limited illness associated with tender lymph nodes, fever, malaise, and fatigue. lymphadenopathy usually resolves spontaneously within three to four months. cat scratch disease can be atypical as indicated by the presentation of our patient. | 1999 | 10461442 |
| shared vector-borne zoonoses of the old world and new world: home grown or translocated? | humans inhabiting the old world and new world share a wide variety of pathogens. processes that result in the disjunct biogeographic distribution of pathogens with common vertebrate reservoirs or vectors are more difficult to unravel than those influencing the distribution of infections spread only through human-to-human transmission. the origins of species and complexes of tick-borne bacteria are unclear. the agent of lyme borreliosis may have speciated in the new world following geographical i ... | 1999 | 10476548 |
| survey of three bacterial louse-associated diseases among rural andean communities in peru: prevalence of epidemic typhus, trench fever, and relapsing fever. | typhus and other louse-transmitted bacterial infections in peruvian sierra communities are known to occur but have not recently been assessed. in this study, 194 of 1,280 inhabitants of four villages in calca province in the urubamba valley were included. thirty-nine (20%) of the 194 volunteers had antibodies to rickettsia prowazekii, whereas 24 (12%) had antibodies to bartonella quintana and 2 against borrelia recurrentis. there was a significant correlation between the presence of infesting ec ... | 1999 | 10476755 |
| coinfection with multiple tick-borne pathogens in a walker hound kennel in north carolina. | both dogs and humans can be coinfected with various ehrlichia, bartonella, rickettsia, and babesia species. we investigated a kennel of sick walker hounds and their owners in southeastern north carolina for evidence of tick-borne infections and associated risk factors. a high degree of coinfection was documented in the dog population. of the 27 dogs, 26 were seroreactive to an ehrlichia sp., 16 to babesia canis, and 25 to bartonella vinsonii, and 22 seroconverted to rickettsia rickettsii antigen ... | 1999 | 10405413 |
| [cat scratch disease]. | 1999 | 10635816 | |
| prevalence of antibodies to bartonella henselae in patients with suspected cat scratch disease (csd) in italy. | cat scratch disease (csd) is a relatively new diagnosed illness with clinical signs of self-limiting regional lymphadenopathy accompanied by symptoms of fever and malaise, to encephalopathy and neuropathy, occurring after a cat scratch or flea bite. bartonella henselae is now accepted as the etiologic agent of csd. from january 1994 to september 1998, 412 patients were evaluated for suspect csd in italy. sera were tested for antibodies to b. henselae by a commercially available indirect immunofl ... | 1999 | 10485354 |
| sequence variation in the ftsz gene of bartonella henselae isolates and clinical samples. | in a search for methods for subtyping of bartonella henselae in clinical samples, we amplified and sequenced a 701-bp region in the 3' end of the ftsz gene in 15 b. henselae isolates derived from cats and humans in the united states and europe. the ftsz sequence variants that were discovered were designated variants bh ftsz 1, 2, and 3 and were compared with 16s rrna genotypes i and ii of the same isolates. there was no ftsz gene variation in the strains of 16s rrna type i, all of which were bh ... | 2000 | 10655367 |
| cloning, sequencing, and expression of three bartonella henselae genes homologous to the agrobacterium tumefaciens virb region. | a 17-kda, immunodominant antigen of bartonella henselae houston-1 has previously been cloned, sequenced, and characterized. this clone (h13) contains the 17-kda antigen gene plus a partial open reading frame, designated orf1, which is 459 nucleotides long and is directly upstream of the 17-kda gene. comparison of the deduced partial amino acid sequence of orf1 with that of other known genes in genbank revealed significant identity with several other bacterial virulence genes, including virb4 of ... | 2000 | 10749166 |
| are bartonella emerging and re-emerging pathogens in southern africa? | 2000 | 10721382 | |
| a bacteriophage-like particle from bartonella bacilliformis. | bartonella bacilliformis and bartonella henselae, the respective agents of oroya fever and cat-scratch disease in humans, are known to produce bacteriophage-like particles (blps) that package 14 kbp segments of the host chromosome. data from this study suggest that other bartonella species including bartonella quintana, bartonella doshiae and bartonella grahamii also contain similar blps, as evidenced by the presence of a 14 kbp extrachromosomal dna element in their genomes, whereas bartonella e ... | 2000 | 10746763 |
| identification of escherichia coli k1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction. | most cases of escherichia coli k1 meningitis arise as a result of haematogenous spread, however there is a limited understanding of the mechanisms by which circulating e. coli k1 cross the blood-brain barrier. we have previously shown that environmental growth conditions both positively and negatively influence the capabilities of e. coli k1 to invade brain microvascular endothelial cells (bmec), for example growth in media supplemented with 50% newborn bovine serum (nbs) increased bmec invasion ... | 2000 | 10760174 |
| prevalence of bartonella henselae, bartonella clarridgeiae and the 16s rrna gene types of bartonella henselae among pet cats in japan. | the authors investigated bacteriologically the prevalence of bartonella infection among 690 pet cats derived from 10 private animal hospitals in six cities (sapporo, hokkaido prefecture; sendai, miyagi prefecture; joetsu, niigata prefecture; fujisawa, kanagawa prefecutre; kyoto, kyoto prefecture; sanda, hyogo prefecutre) and 4 counties (mishima, osaka prefecture; hikawa, shimane prefecture; aira, kagoshima prefecture; shimajiri, okinawa prefecture) located from the north to the south of japan. b ... | 2000 | 10770599 |
| in vitro activities of telithromycin (hmr 3647) against rickettsia rickettsii, rickettsia conorii, rickettsia africae, rickettsia typhi, rickettsia prowazekii, coxiella burnetii, bartonella henselae, bartonella quintana, bartonella bacilliformis, and ehrlichia chaffeensis. | in vitro activities of telithromycin compared to those of erythromycin against rickettsia spp., bartonella spp., coxiella burnetii, and ehrlichia chaffeensis were determined. telithromycin was more active than erythromycin against rickettsia, bartonella, and coxiella burnetii, with mics of 0.5 microg/ml, 0.003 to 0.015 microg/ml, and 1 microg/ml, respectively, but was inactive against ehrlichia chaffeensis. | 2000 | 10770788 |
| visceral manifestation of cat scratch disease in children. a consequence of altered immunological state? | a 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. ultrasound and ct scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. screening for zoonosis revealed high positive titers to bartonella henselae. t-cell deficiency was demonstrated and remained almost unchanged during a follow-up of 11 months. a review of the literature shows that disseminated visceral affection is a rare presentation of cat scratch disease (csd) in child ... | 2000 | 10782400 |
| rapid identification and differentiation of bartonella species using a single-step pcr assay. | five species of bartonella have been reported to infect humans and cause a variety of diseases that can be difficult to diagnose. four species of bartonella have been reported to infect cats and dogs, and two of these species are considered to be zoonotic pathogens. diagnosis of bartonella infections is hampered by the slow, fastidious growth characteristics of bartonella species. we report on the development of a single-step pcr-based assay for the detection and differentiation of medically rel ... | 2000 | 10790087 |
| [a "diagnosis of goldsmith"]. | 2000 | 10916845 | |
| bartonella henselae infection as a cause of fever of unknown origin. | fourteen of 41 patients (34%) with a serological diagnosis of bartonella henselae infection were found to have prolonged fever or fever of unknown origin, suggesting that generalized systemic b. henselae infection is not rare in immunocompetent healthy individuals. | 2000 | 10790137 |
| subtyping of uncultured bartonellae using sequence comparison of 16 s/23 s rrna intergenic spacer regions amplified directly from infected blood. | this study aimed to assess the usefulness of a pcr-based approach to the detection and differentiation of bartonella strains in infected blood. the conservation of potential genus-specific pcr primer hybridisation sites within the 16 s/23 s rrna gene intragenic spacer regions of bartonella species was confirmed following sequence analysis of the intragenic spacer regions of four previously untested species. the extent of intra-species variation within the specific amplicons was assessed by compa ... | 2000 | 10799268 |
| bartonella spp. isolated from wild and domestic ruminants in north america. | bartonella species were isolated from 49% of 128 cattle from california and oklahoma, 90% of 42 mule deer from california, and 15% of 100 elk from california and oregon. isolates from all 63 cattle, 14 deer, and 1 elk had the same polymerase chain reaction/restriction fragment length polymorphism profiles. our findings indicate potential for inter- and intraspecies transmission among ruminants, as well as risk that these bartonella spp. could act as zoonotic agents. | 2000 | 10827123 |
| isolation in endothelial cell cultures of chlamydia trachomatis lgv (serovar l2) from a lymph node of a patient with suspected cat scratch disease. | an inguinal lymph node, removed from a 21-year-old romanian man suspected of having cat scratch disease, was sent to our laboratory for bartonella culture. lymph node specimens were inoculated on blood-enriched agar and in an endothelial cell culture system using the centrifugation shell vial technique. bacteria were grown in cell monolayers and detected as positive with an anti-bartonella henselae rabbit serum. however, such bacteria were identified as chlamydia trachomatis biovar lgv serovar l ... | 2000 | 10834954 |
| endotoxin and nanobacteria in polycystic kidney disease. | microbes have been suspected as provocateurs of polycystic kidney disease (pkd), but attempts to isolate viable organisms have failed. bacterial endotoxin is the most often reported microbial product found in pkd fluids. we assessed potential microbial origins of endotoxin in cyst fluids from 13 pkd patients and urines of pkd and control individuals. | 2000 | 10844606 |
| [clinical evaluation of commercial serological test for bartonella infection]. | we evaluated the usefulness of a serological diagnostic kit (bartonella ifa igg, igm; mrl diagnostics) for bartonella henselae infection. of the 110 healthy individuals, 107 (97.3%) were with titers being less than 1:64 for igg antibody to b. henselae, 2 were with titers being 1:64 and 1 with 1:128, igm antibody to b. henselae was negative in all individuals. serological diagnosis of cat scratch disease (csd) using indirect fluorescence antibody (ifa) methods (in-house and diagnostic kit) was ma ... | 2000 | 10835846 |
| clinical disease in kittens inoculated with a pathogenic strain of bartonella henselae. | to evaluate disease in kittens inoculated with bartonella henselae strain lsu16. | 2000 | 10772100 |
| bartonella interactions with host cells. | 2000 | 10804853 | |
| cat scratch disease: posterior segment manifestations. | 2000 | 10811065 | |
| prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis. | to determine the prevalence of bartonella henselae seropositivity in patients with a clinical diagnosis of neuroretinitis. | 2000 | 10811077 |
| conservation of the 17-kilodalton antigen gene within the genus bartonella. | the 17-kda antigen of bartonella henselae has previously been shown to elicit a strong humoral immune response in patients with cat scratch disease (csd) and to be useful in screening human serum samples for csd. in this study, pcr amplification of genes homologous to the 17-kda antigen gene of b. henselae was performed using genomic dnas from several species of bartonella, including the currently recognized human pathogens. amplicons of similar size were demonstrated using the following chromos ... | 2000 | 10702501 |
| in vitro susceptibilities of rickettsia and bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected vero cell monolayers. | the in vitro susceptibilities of rickettsia akari, rickettsia conorii, rickettsia prowazekii, rickettsia rickettsii, bartonella elizabethae, bartonella henselae and bartonella quintana to different concentrations of clarithromycin, 14-hydroxy-clarithromycin (the primary metabolite of clarithromycin) and tetracycline in vero cell cultures, were determined by enumeration of immunofluorescently-stained bacilli. the extent of antibiotic-induced inhibition of foci was recorded for each dilution of an ... | 2000 | 10702548 |
| patterns of infection of haemoparasites in the fat sand rat, psammomys obesus, in tunisia, and effect on the host. | two bacterial and one protozoan blood parasite, belonging to the genera bartonella, borrelia and babesia, were studied in a tunisian population of psammomys obesus. seasonal changes in the abundance of the parasites and host were monitored in a longitudinal field survey lasting 17 months. blood samples collected during eight rodent-trapping sessions, between september 1995 and january 1997, were examined microscopically. bartonella sp. showed a seasonal pattern, with most transmission occurring ... | 2000 | 10723524 |
| bartonellosis. new and old. | the number of species that comprise the family of bartonellaceae, genus bartonella, has recently increased from one to 11 species, five of which have been associated with different diseases and syndromes in humans. the rapidly growing number of human pathogens has led several investigators to regard bartonellosis and other associated syndromes as important emerging infectious diseases. this article presents the history and epidemiology, clinical features, diagnosis, and treatment of bartonellosi ... | 2000 | 10738670 |
| bacillary angiomatosis by bartonella quintana in an hiv-infected patient. | bacillary angiomatosis and bacillary peliosis are opportunistic infections caused by bartonella henselae and bartonella quintana, which occur in patients with late-stage infection. we report a case of bacillary angiomatosis in an hiv-infected patient with skin, bone, and probably liver involvement, the identification of the agent (b quintana ) was done by polymerase chain reaction in the skin specimen. the patient had complete regression of all lesions after a 6-month regimen of oral erythromyci ... | 2000 | 10642694 |
| sonicated diagnostic immunoblot for bartonellosis. | two simple bartonella bacilliformis immunoblot preparation methods were developed. antigen was prepared by two different methods: sonication of whole organisms or glycine extraction. both methods were then tested for sensitivity and specificity. well-defined control sera were utilized in the development of these diagnostic immunoblots, and possible cross-reactions were thoroughly examined. sera investigated for cross-reaction with these diagnostic antigens were drawn from patients with brucellos ... | 2000 | 10618267 |
| species-specific monoclonal antibodies for rapid identification of bartonella quintana. | seven species-specific monoclonal antibodies (mabs) to bartonella quintana were produced and characterized. the mabs were of the immunoglobulin g class and reacted only with 13 b. quintana strains in indirect microimmunofluorescence and western immunoblotting assays. they did not react with eight other bartonella spp., including bartonella henselae, the most closely related species, and a selected mab did also not react with nine other strains of gram-negative bacteria. the mabs reacted mainly w ... | 2000 | 10618271 |
| contact-dependent hemolytic activity distinct from deforming activity of bartonella bacilliformis. | although bartonella bacilliformis causes a severe anemia in humans, this study presents the first report of hemolytic activity by b. bacilliformis. the activity was not apparent in culture supernatants but was reliably detected when b. bacilliformis cells were centrifuged onto erythrocytes prior to incubation. abrogation of hemolytic activity by proteinase k treatment suggested the hemolysin was a bartonella protein. even though hemolysis required relatively long incubation times, de novo protei ... | 2000 | 10612742 |
| bartonella infection: a significant cause of native valve endocarditis necessitating surgical management. | 2000 | 10612779 | |
| prevalence of bartonella henselae antibody in florida panthers. | serum samples from 28 free-ranging florida panthers (puma concolor coryi) and seven mountain lions from texas (p. concolor stanleyana) living in south florida (usa) between 1997 to 1998 were tested for antibodies to bartonella henselae. twenty percent (7/35) of the samples were reactive to b. henselae antisera with a subspecies prevalence of 18% (5/ 28) for florida panthers and 28% (2/7) for cougars from texas (usa). there was not a significant sex related difference in infection rates among the ... | 2000 | 10682759 |
| granulomatous disease associated with bartonella infection in 2 dogs. | shortly after removal of an engorged tick from the left ear, a 4-year-old greyhound was referred for evaluation of fever and a rapidly enlarging mass in the region of the left submandibular lymph node. histopathologic evaluation of the lymph node resulted in a diagnosis of severe granulomatous lymphadenitis. an 11-year-old mixed-breed dog was referred for evaluation of a 6-week history of serous nasal discharge. histologic examination of a surgical biopsy from a nasal mass indicated multifocal g ... | 2000 | 10668815 |
| bartonella vinsonii subsp. berkhoffii as an agent of afebrile blood culture-negative endocarditis in a human. | we report a case of endocarditis in a human infected with bartonella vinsonii subsp. berkhoffii, which causes bacteremia and endocarditis in dogs. bacterial identification was established by pcr amplification and sequencing of an intergenic spacer region (its1), 16s ribosomal dna, and a gene encoding citrate synthase (glta). bartonella antibodies were detected by immunofluorescence. | 2000 | 10747175 |
| peliosis hepatis in a dog infected with bartonella henselae. | a 6-year-old spayed female golden retriever was examined because of generalized weakness and abdominal distention. abdominal ultrasonography revealed a large quantity of peritoneal fluid. in addition, the liver appeared larger than normal and contained multiple, small, nodular masses and cyst-like structures. abdominal exploratory surgery was performed, and 5 l of serosanguineous peritoneal fluid was removed. gross lesions were not found in the stomach, kidneys, intestines, adrenal glands, or ur ... | 2000 | 10687006 |
| metal requirements of a diadenosine pyrophosphatase from bartonella bacilliformis: magnetic resonance and kinetic studies of the role of mn2+. | recombinant iala protein from bartonella bacilliformis is a monomeric adenosine 5'-tetraphospho-5'-adenosine (ap4a) pyrophosphatase of 170 amino acids that catalyzes the hydrolysis of ap4a, ap5a, and ap6a by attack at the delta-phosphorus, with the departure of atp as the leaving group [cartwright et al. (1999) biochem. biophys. res. commun. 256, 474-479]. when various divalent cations were tested over a 300-fold concentration range, mg2+, mn2+, and zn2+ ions were found to activate the enzyme, w ... | 2000 | 10694402 |
| parapharyngeal abscess due to cat-scratch disease. | the spectrum of illness attributed to cat-scratch disease (csd) continues to expand. although a common cause of cervical adenitis in children, csd has not been associated as a cause of deep fascial space infections of the head and neck. we describe a child with extensive parapharyngeal adenitis and abscesses due to csd confirmed by histological and serological evaluations. | 2000 | 10722453 |
| detection of selected fastidious bacteria. | the intent of this article is to describe the optimal methods for culture recovery of 7 fastidious bacteria: legionella species, brucella species, francisella tularensis, leptospira species, borrelia burgdorferi, bartonella species, and bordetella species. these organisms share much in common beyond the fact that their genus names all end in the letter "a." culture recovery of these organisms, even from adequate clinical specimens, is logistically demanding, often costly, and lacking in both tim ... | 2000 | 10619747 |
| hemin-dependent growth and hemin binding of bartonella henselae. | bartonella henselae causes cat-scratch disease and bacillary angiomatosis peliosis. the bacteria reside in erythrocytes of asymptomatic cats, which represent the natural reservoir for this pathogen. b. henselae is usually grown on blood-enriched media. growth experiments on brucella medium without blood demonstrated that heme compounds are essential for the growth of b. henselae and can completely substitute the addition of blood components. the heme precursor protoporphyrin ix alone, or in comb ... | 2000 | 10913865 |
| are bartonella emerging and re-emerging pathogens in southern africa? | 2000 | 10918880 | |
| characterization of bartonella clarridgeiae flagellin (flaa) and detection of antiflagellin antibodies in patients with lymphadenopathy. | cat scratch disease (csd) is a frequent clinical outcome of bartonella henselae infection in humans. recently, two case reports indicated bartonella clarridgeiae as an additional causative agent of csd. both pathogens have been isolated from domestic cats, which are considered to be their natural reservoir. b. clarridgeiae and b. henselae can be distinguished phenotypically by the presence or absence of flagella, respectively. separation of the protein content of purified flagella of b. clarridg ... | 2000 | 10921956 |
| differentiation of pathogenic bartonella species by infrequent restriction site pcr. | infrequent restriction site pcr (irs-pcr) is a recently described dna fingerprinting technique based on selective amplification of restriction endonuclease-cleaved fragments. bartonella isolates associated with human disease and related nonhuman isolates were analyzed by irs-pcr genomic fingerprinting. preparation of dna templates began with double digestion using three different restriction endonuclease combinations. combinations included the frequently cutting endonuclease hhai in conjunction ... | 2000 | 10921969 |
| natural history of infection with bartonella bacilliformis in a nonendemic population. | an investigation was performed after an outbreak of bartonellosis in a region of peru nonendemic for this disorder. symptoms of acute and chronic bartonellosis were recorded. serological analysis was performed on 55% of the affected population (554 individuals), 77.5% of whom demonstrated previous infection with bartonella bacilliformis. the attack rate of oroya fever was 13.8% (123 cases); the case-fatality rate was 0.7%. the attack rate of verruga peruana was 17.6%. a new specific immunostain ... | 2000 | 10950782 |
| [evaluation of serological response to bartonella henselae by enzyme immunoassay in cat scratch disease]. | the igg and igm titers to bartonella henselae were determined by an enzyme immunoassay (eia). the eia test for detection of igg and igm antibodies to b. henselae concerning csd showed that 8 (40%) of 20 patients with csd had a serum igg antibody titer of 12 eia unit or more and that 5 (25%) patients had a serum igm titer of 12 eia unit or more. totally 12 (60%) of the 20 patients with csd were seropositive for b. henselae. the mean age of igg positive patients were higher than igm positive patie ... | 2000 | 10965658 |
| neuroretinitis associated with cat scratch disease in a child. | 2000 | 10933777 | |
| [cat-scratch disease caused by bartonella quintana in an infant: an unusual presentation]. | this case study reports a typical clinical course of cat-scratch disease (csd) in an infant without epidemiological data and presenting bilateral submandibular lymphadenopathy. the authors describe clinical course, ultrasound images, diagnosis and prognosis. polymerase chain reaction (pcr) detected and identified b. quintana in lymph node samples. b. henselae currently thought to be the causative agent of csd was not detected. the pcr assays for b. quintana and b. henselae should be available fo ... | 2000 | 10967601 |
| interaction of bartonella bacilliformis with human erythrocyte membrane proteins. | intracellular invasion is an important aspect of carrión's disease caused by bartonella bacilliformis. both the hematic and tissue phases of the disease involve the initial attachment of the organism to erythrocytes and endothelial cells, respectively. using two different approaches, preliminary evidence is provided that b. bacilliformis interacts with multiple surface-exposed proteins on human erythrocytes. utilizing western blot analysis, it was demonstrated that the organism binds several bio ... | 2000 | 10968948 |
| ocular bartonellosis. | to review recent advances in the basic and clinical biology of bartonella-related eye disease. | 2000 | 11020414 |
| infection of human endothelial cells with bartonella bacilliformis is dependent on rho and results in activation of rho. | bartonella bacilliformis was continuously internalized into human endothelial cells beginning shortly after addition of the bacteria and continuing for at least 24 h after infection in vitro, with a major increase in uptake occurring between 16 and 24 h. preincubation of endothelial cells with c3 exoenzyme, which inactivated intracellular rho-gtpase, blocked internalization of the bacteria. addition of c3 exoenzyme at any time after addition of the bacteria blocked further internalization of bac ... | 2000 | 10992508 |
| transcriptional activation of the htra (high-temperature requirement a) gene from bartonella henselae. | bacterial htra genes are typically activated as part of the periplasmic stress response and are dependent on the extracytoplasmic sigma factor rpoe. a putative promoter region, p1, of the sigma(e)-type heat-inducible promoters has previously been identified upstream of the htra gene of bartonella henselae. further analysis of the htra mrna by primer extension demonstrated that transcription initiates from p1 and a second region downstream of p1. this second promoter region, termed p2, had no seq ... | 2000 | 10992509 |
| bartonella henselae, b. quintana, and b. bacilliformis: historical pathogens of emerging significance. | bartonella species were virtually unrecognized as modern pathogens of humans until the last decade. however, identification of bartonella species as the agents of cat-scratch disease, bacillary angiomatosis, urban trench fever, and possible novel presentations of carrion's disease has left little doubt of the emerging medical importance of this genus of organisms. the three primary human pathogenic bartonellae, bartonella bacilliformis (carrion's disease), b. henselae (cat-scratch disease), and ... | 2000 | 11008109 |