Publications

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genetic and physical map of the chromosome of hemophilus influenzae. 19695308523
selective culture medium to survey the incidence of haemophilus species.a culture medium for the selective isolation of haemophilus species is described. bacitracin and nutritional supplements were incorporated in a rich basal agar medium to which rabbit blood was added to distinguish hemolytic species. colony counts of seven typed strains of h. influenzae on this medium were within practical limits of counts on other media tested for clinical use. the bacitracin medium was as reliable as hemoglobin-agar for detecting h. influenzae and more sensitive for detecting o ...19695308660
haemophilus influenzae type b septicaemia.in the period november 1967 to september 1968 haemophilus influenzae type b was isolated from the blood of 11 young children. only three of these presented with meningitis; others had septic arthritis, oesteomyelitis, subcutaneous abscesses, cellulitis, respiratory infections, and undifferentiated pyrexia. during the preceding five years h. influenzae type b was isolated from the blood cultures of 15 patients, and all but two of these were cases of meningitis. blood culture has proved of value i ...19695303988
effects of antibiotics on induction, viability, and reversion potential of l-forms of haemophilus influenzae.l-form variants of haemophilus influenzae were found to be more susceptible than their parent bacilli to streptomycin, kanamycin, tetracycline, erythromycin, and chloramphenicol if l-form inducer, penicillin, was present. this greater susceptibility was defined as the bactericidal effect for the variant forms of a concentration of antibiotic that is lower than but approximates the level bacteriostatic for the parents. in the absence of penicillin, reversion to and growth as bacilli occurred, alt ...19695305776
incomplete bacteriophage-like particles in ultraviolet-irradiated haemophilus.incomplete phagelike particles were found in competent and incompetent cells of haemophilus influenzae rd (transformable) lysed after exposure to ultraviolet radiation.19695305777
haemophili from eyes.the identity of haemophili isolated in our laboratories from eye swabs was investigated. ten out of 114 strains belonged to capsulated types of h. influenzae. seventy-six strains were submitted to tests for the identification of h. aegyptius (the koch-weeks bacillus), but none was proved to belong to this species. an unexpectedly high proportion of the haemophilus strains, including most of those with capsules, came from patients with lachrymal duct obstruction.19695305825
serine biosynthesis and regulation in haemophilus influenzae.nutritional mutants of haemophilus influenzae requiring l-serine for growth were shown to be deficient in their capacity to synthesize serine-phosphate from 3-phosphoglycerate. on the basis of the correlation between this block and the requirement for an exogenous supply of the amino acid, it was concluded that the "phosphorylated" pathway is the only pathway used by h. influenzae for serine biosynthesis. serine inhibits serine-phosphate production, thereby regulating its own synthesis in a mann ...19695305003
ultraviolet inactivation and photoproducts of transforming dna irradiated at low temperatures.solutions of haemophilus influenzae transforming dna were irradiated at temperatures ranging from 25 degrees c to - 196 degrees c. temperature dependence of the formation of thymine-containing dimers was closely correlated with inactivation of transforming activity; in general, both dimerization and inactivation decreased with decreasing temperature. the fraction of nonphotoreactivable damage increased with increasing dose at low temperatures. the nonphotoreactivable spore-type photoproduct was ...19695305089
bacteriologic relapse during ampicillin treatment of hemophilus influenzae meningitis. 19695305115
relapse of hemophilus influenzae type b meningitis during intravenous therapy with ampicillin. 19695305116
chromatography of nucleic acids on hydroxyapatite. ii. chromatography of denatured dna. 19695304984
failure of response to ampicillin in hemophilus influenzae meningitis. 19695304512
haemophilus influenzae: growth stimulation by atmospheric pollutants. 19695304739
acute infectious epiglottitis in adults. 19695304385
cephaloridine in the treatment of acute exacerbations of chronic bronchitis. 19695314680
pilot study of factors associated with exacerbations in chronic bronchitis.the factors associated with exacerbations of chronic bronchitis were investigated in a pilot study of 23 male patients over a period of 29 months. there were 63 exacerbations-56 were fully investigated and in seven only serological studies were possible. evidence of the presence of an infective agent was sought in the early stages of the exacerbations and during relative quiescence. significantly more potential pathogens, both bacterial (pneumococci and haemophilus influenzae) and viral and myco ...19695349300
[on a case of waterhouse-friderichsen syndrome caused by haemophilus influenzae]. 19695314393
phagocytic and bactericidal activities of peritoneal and alveolar macrophages from mice. 19695314333
dependence of vegetative recombination among haemophilus influenzae bacteriophage on the host cell.vegetative recombination of temperature-sensitive mutants of haemophilus influenzae phage hp1 cl was measured in wild-type h. influenzae strain rd and in strain db117, an ultraviolet-sensitive, transformation-defective mutant of the rd strain. recombinants are formed with low frequency in wild-type cells, but no recombination was detectable in db117. it is concluded that these phage make use of the host cell enzymes for vegetative recombination. lysogenization readily takes place in both strains ...196916789099
urinary incontinence among patients with arthritis--a neglected disability.urinary tract pathology may be no more common in patients with arthritis than among the general population, but its impact may be enhanced by disability. in this survey of 247 patients, as many as 38% of patients with rheumatoid arthritis (ra), 47% of patients with osteoarthritis (oa) and even 34% of patients with soft tissue rheumatism (str) reported difficulty controlling their urine, confirming that incontinence is a widespread and often under-reported problem. more detailed enquiry in a samp ...19691629846
[late results of conservative-surgical treatment of chronic diseases of the periapical tissue]. 1969284889
attitudes concerning water fluoridation among graduating swedish dentists.the purpose of the investigation was to assess the attitudes concerning water fluoridation among swedish dentists just having completed their dental education. all senior dental students (168) at the four swedish dental schools were handed a questionnaire during the last week of november 1974. by the end of february 1975, 98% of the respondents, now dentists, had returned their questionnaires. water fluoridation was considered by the average respondent to be quite economical and effective but on ...1969284881
implications of the primary prevention trials against coronary heart disease.the bulk of the mortality (60%) in hypertension occurs in those with mild to moderate elevations of blood pressure, and the chief hazard is coronary disease. although progression in the severity of hypertension has been slowed with drug therapy, the benefits for coronary outcome and all-cause mortality have been equivocal. only a 10% reduction in coronary heart disease morbidity and mortality has been shown, an improvement that is not only small, but is statistically insignificant. only vascular ...19691982770
[methods in nursing surveys. 6. methods in the case studies]. 1969249855
on the universality of nuclear pore complex structure. 19704097097
a cannula of variable depth for chemical stimulation of the brain. 19704097443
studies on equine immunoglobulins. i. the antigenic structure of horse igg, its fragments and subunits. 19704097705
structure and innervation of the ciliary processes of the albino rabbit eye. 19704097733
antibody response to plasmodium falciparum malaria. comparisons of immunoglobulin concentrations, antibody titres and the antigenicity of different asexual forms of the parasite. 19704097746
influence of a bacillus on the reversion of hemophilus influenzae l forms to the bacterial form. 19704098095
artificial cryptorchidism and fertility in the rabbit. 19704099419
rifampicin, myambutol, isoxyl, and capreomycin as combination partners in animal experiments. 19704108897
observations on the use of diazo-i-h-tetrazole and phenylglyoxal in protein histochemistry as applied to human gingiva. 19704112987
studies of absorption, excretion, antibacterial and clinical effect of cephalexin. 19704398634
influence of pyridoxine on tyrosine transaminase activity in maternal and fetal rat liver. 19704392301
[is there a place for rifampicin in the treatment of bacterial bronchopulmonary infections?]. 19704393036
the mechanism of genetic recombination. 19704393688
[meningitis. 6,957 cases confined at the "emilio ribas" hospital (são paulo) during the 1958-1967 decade. occurrence, etiology and mortality]. 19704393708
the effect of magnesium ions and tris buffer on the uptake of cetyl trimethyl ammonium bromide by escherichia coli. 19704394783
inhibition of rna synthesis by alpha-amanitin in vivo. 19704394866
response of dog's femoral artery strips to vasoactive substances. 19704395622
[the side-effects of the therapy of chronic lung diseases with antibiotics]. 19704396624
[mechanism of action of oxyfedrin]. 19704397500
preparation of glutamate dehydrogenase from micrococcus aerogenes. 19704397848
susceptibility of diplococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis to 23 antibiotics. 19704398824
[chemotherapy of purulent meningitis]. 19704398442
[effect of glucocorticoids on the eye tissue mucopolysaccharides in rabbits and the state of ophthalmotonus regulation]. 19704248797
changes in enzymic activity, chemical composition and histology of the mammary glands and metabolites in the blood of lactating rabbits after hypophysectomy and replacement therapy with sheep prolactin, human growth hormone or bovine growth hormone. 19704249303
[histocytochemistry of the periodontium of white rats in experimental and spontaneous parodontopathy]. 19704249422
the neuromuscular blocking action of pancuronium in man during anaesthesia. 19704249574
studies on the structure of the mitochondrial membranes. 19704245917
studies of cellular proliferation in human leukemia. 3. behavior of leukemic cells in three adults with acute leukemia given continuous infusions of 3h-thymidine for 8 or 10 days. 19704246416
effect of crosslinking on glycerinated muscle fibres by formaldehyde & glutaraldehyde. 19704248653
[hypersomnia and increase of cerebral 5-hydroxyindoleacetic acid due to isthmic lesions in the cat]. 19704257361
[effect of an antihistamic preparation (dimedrol) on the morphology and function of connective tissue cellular elements under conditions of aseptic inflammation]. 19704255085
haemophilus influenzae meningitis in an adult. a study of bactericidal antibodies and immunoglobulins. 19704188313
[immunohistologic studies of experimental nephritis. i. masugi nephritis]. 19704188559
effect of antilymphocyte antibody on humoral antibody formation. 19704189494
partial characterization of antigenic streptococcal plasma membrane components in acute glomerulonephritis.fluorescein-labeled immunoglobulin g (igg) fractions of serum from patients with acute poststreptococcal glomerulonephritis stained parts of the glomerular basement membrane and mesangium of kidney tissue obtained from the same patients during the early phase of the disease. renal tissue obtained from normal individuals and from patients with other kidney diseases failed to stain with these igg fractions. preabsorption of the serum fractions with various freezethawed bacteria demonstrated that o ...19704191907
emetine myopathy. 19704195358
[a rapid method for the preparation of highly purified transforming dna]. 19704323692
[renin substrate reaction and renin release by the isolated rabbit kidney]. 19704326418
[unitary responses in hypothalamus anterior and median areas associated with variations in arterial pressure and volemia]. 19704313945
late 19s rabbit antibody neutralization test for differentiating herpes simplex virus types 1 and 2. 19704314178
endonuclease from micrococcus luteus which has activity toward ultraviolet-irradiated deoxyribonucleic acid: its action on transforming deoxyribonucleic acid.an endonuclease purified from micrococcus luteus makes single-strand breaks in ultraviolet (uv)-irradiated, native deoxyribonucleic acid (dna). the purified endonuclease is able to reactivate uv-inactivated transforming dna of haemophilus influenzae, especially when the dna is assayed on a uv-sensitive mutant of h. influenzae. after extensive endonuclease action, there is a loss of transforming dna when assayed on both uv-sensitive and -resistant cells. the endonuclease does not affect unirradia ...19704314478
[ribonucleic acid of parainfluenza vius type 3]. 19704315821
synergistic effect in viral-bacterial infection. 2. influence of viral infection on the phagocytic ability of alveolar macrophages. 19704316170
on the mechanism of action of adrenocorticotropic hormone. stimulation of deoxyribonucleic acid polymerase and thymidine kinase activities in adrenal glands. 19704316775
poultry: principles of disease control. 3. vaccination. 19704317297
ampicillin levels in sputum, serum, and saliva. 19704318047
an exonuclease specific for double stranded deoxyribonucleic acid. 19704319239
[effect of clostridium histolyticum collagenase on hexa- and polypeptides]. 19704319428
electron spin resonance of malignant human tissue. 19704319520
[formation of toxins by clostridium perfringens types c and d]. 19704320342
arthritis associated with known infectious agents. 19704321236
studies on inhibition of viral oncogenesis. ii. inhibitory effect of l-asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation. 19704322843
[biochemical, morphological and functional disorders of the higher nerve centers in rabbits with experimental periodontosis, induced by irritation of the dental pulp with tricresol-formalin and eugenol]. 19704322957
reactivatability of soman-inhibited end plate cholinesterase and neuromuscular transmission. 19704313633
the distribution of the mouse mammary tumor agent and its antigenicity in milk. 19704313229
hospital-acquired herpes zoster following exposure to chickenpox. 19704313291
variability of herpes simplex virus: isolation of two variants from simultaneous eruptions at different sites. 19704313188
effects of antilymphocytic serum on host responses to infectious agents. 19704312737
effect of nitrate, fumarate, and oxygen on the formation of the membrane-bound electron transport system of haemophilus parainfluenzae.the composition of the membrane-bound electron transport system of haemophilus parainfluenzae underwent modification in response to the terminal electron acceptor in the growth medium. h. parainfluenzae was able to grow with o(2), nitrate, fumarate, pyruvate, and substrate amounts of nicotinamide adenine dinucleotide (nad) as electron acceptors. when o(2) served as the electron acceptor and its concentration was lowered below 20 mum, the bacteria formed more cytochromes b, c, a(1), a(2), and o t ...19704313051
radiation inhibition of peritoneal adhesions: an experimental study. 19704313143
immunogenicity of rhinoviruses. 19704313149
the association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. 19704341456
cyclic amp and adenyl cyclase in the developing rat brain. 19704353393
[cortico-adrenal disturbances in chronic respiratory insufficiency patients]. 19704330336
[cortico-adrenal disturbances in chronic respiratory insufficiency patients]. 19704330336
antibody responses to bacterial antigens during exacerbations of chronic bronchitis. 19704391477
reversal of penicillin-induced l-phase growth of haemophilus influenzae by spermine and its effects on antibiotic susceptibility.spermine at a concentration of 0.001 m initiated the reversion of penicillin-induced l-phase growth of haemophilus influenzae to bacillary growth on penicillin l-phase medium. reversion of l-phase colonies to bacillary colonies required 3 to 5 days. this spermine reversal of variant growth also occurred on penicillin induction medium in the presence of concentrations of tetracycline, erythromycin, and chloramphenicol that were not bactericidal for l-phase or bacillary inocula until 48 or more hr ...197016557761
analysis of photoenzymatic repair of uv lesions in dna by single light flashes. vi. rate constants for enzyme-substrate binding in vitro between yeast photoreactivating enzyme and ultraviolet lesions in haemophilus transforming dna. 19705314612
analysis of photoenzymatic repair of uv lesions in dna by single light flashes. vii. photolysis of enzyme-substrate complexes in vitro. 19705314613
an electron microscopic study of the relation between length and transforming activity of h. influenzae dna. 19705315288
[clinical observations with rifampicin, a new bactericidal antibiotic]. 19705315020
ultraviolet-induced decrease in integration of haemophilus influenzae transforming deoxyribonucleic acid in sensitive and resistant cells.the decrease in integration of transforming deoxyribonucleic acid (dna) caused by ultraviolet irradiation of the dna was found to be independent of the presence or absence of excision repair in the recipient cell. much of the ultraviolet-induced inhibition of integration resulted from the presence in the transforming dna of pyrimidine dimers, as judged by the photoreactivability of the inhibition with yeast photoreactivating enzyme. the inhibition of integration made only a small contribution to ...19705308769
defined medium for growth of haemophilus influenzae.a chemically defined medium (mi(c)) is described in which cells of haemophilus influenzae rd grow rapidly (generation time, 35 +/- 5 min) and reach a stationary level of 10(10) cells/ml. our strain of cells grown in this medium developed high levels of competence when transferred to another medium designed for that purpose. conditions governing the total development of competence in this organism have now been defined.19705308770
defined nongrowth media for stage ii development of competence in haemophilus influenzae.the composition of a defined nongrowth medium used in stage ii development of competence of haemophilus influenzae affects the course of this development. the development of competence in two nongrowth media, m-iv and m-v, is rapid, logarithmic, and independent of the cell concentration. this last property indicates that there is probably no transfer of a competence factor from competent to noncompetent cells, in contrast to results reported for other organisms. levels of competence reached in t ...19705308771
thymine and thymidine uptake by haemophilus influenzae and the labeling of deoxyribonucleic acid.the influence of ribo- and deoxyribonucleosides and ribo- and deoxyribonucleotides on the uptake of radiolabeled thymidine and thymine by haemophilus influenzae during growth was investigated. a nucleoside-degrading enzyme similar to that reported in escherichia coli was found to break down thymidine unless other nucleosides were present to divert its action. the presence of other nucleosides permitted a nearly quantitative uptake of even low levels of thymidine. this quantitative uptake of thym ...19705308772
[diminished immunological defense. i. basic aspects and clinical picture]. 19705308820
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