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edwardsiella tarda sepsis in a live-stranded sperm whale (physeter macrocephalus).whale strandings remain poorly understood, although bacterial infections have been suggested to contribute. we isolated edwardsiella tarda from the blood of a stranded sperm whale. the pathogen was identified with maldi-tof ms, confirmed by 16s rrna gene sequencing and quantified in blood by qpcr. we report the first case of sepsis in a sperm whale. the zoonotic potential of e. tarda and the possible role of bacterial infections in the enigmatic strandings of cetaceans are discussed.201323827352
the major fimbrial subunit protein of edwardsiella tarda: vaccine potential, adjuvant effect, and involvement in host infection.edwardsiella tarda is a gram-negative bacterium that is reckoned one of the most severe fish pathogens. in this study, we analyzed the biological properties of the e. tarda major fimbrial subunit protein, fima. we found that mutation of fima resulted in defective biofilm growth, attenuated infectivity against host cells, and impaired ability to disseminate into and colonize host tissues following experimental infection. when used as a subunit vaccine, recombinant fima (rfima) elicited a high lev ...201323811351
akirin2 homologues from rock bream, oplegnathus fasciatus: genomic and molecular characterization and transcriptional expression analysis.akirins are conserved nuclear resident nf-κb signaling pathway molecules. isoforms of akirins found in various organisms are known to play diverse roles. in this study, we have characterized two akirin2 homologues from rock bream, ofak2(1) and ofak2(2). the proteins derived from ofak2(1) and ofak2(2) revealed the presence of nuclear localization signal. multiple sequence alignment and pairwise alignment of ofak2(1) and ofak2(2) with the akirin homologues, revealed high conservation and identity. ...201323770624
molecular characterisation and expression analysis of the cathepsin h gene from rock bream (oplegnathus fasciatus).cathepsins are lysosomal cysteine proteases belonging to the papain family, whose members play important roles in normal metabolism for the maintenance of cellular homeostasis. rock bream (oplegnathus fasciatus) cathepsin h (rbctsh) cdnas were identified by expressed sequence tag analysis of a lipopolysaccharide-stimulated rock bream liver cdna library. the full-length rbctsh cdna (1326 bp) contained an open reading frame of 978 bp encoding 325 amino acids. the presence of an erfnin-like motif w ...201323629026
structure of the o-polysaccharide of edwardsiella tarda pcm 1156.mild acid degradation of the lipopolysaccharide of edwardsiella tarda pcm 1156 afforded an o-polysaccharide, which was isolated by gel-permeation chromatography on sephadex g-50 and studied by sugar and methylation analyses along with (1)h nmr and (13)c nmr spectroscopy, including 2d (1)h,(1)h cosy, tocsy, roesy, (1)h,(13)c hsqc, and hmbc experiments. the following structure of the linear tetrasaccharide repeating unit of the o-polysaccharide was established: [structure: see text].201323623959
comparative analysis of edwardsiella isolates from fish in the eastern united states identifies two distinct genetic taxa amongst organisms phenotypically classified as e. tarda.edwardsiella tarda, a gram-negative member of the family enterobacteriaceae, has been implicated in significant losses in aquaculture facilities worldwide. here, we assessed the intra-specific variability of e. tarda isolates from 4 different fish species in the eastern united states. repetitive sequence mediated pcr (rep-pcr) using 4 different primer sets (eric i & ii, eric ii, box, and gtg5) and multi-locus sequence analysis of 16s ssu rdna, groel, gyra, gyrb, pho, pgi, pgm, and rpoa gene frag ...201323623688
genomic characterization and transcriptional evidence for the involvement of complement component 7 in immune response of rock bream (oplegnathus fasciatus).the complement component 7 (c7) is the central mediator of pathogenic attack at the membrane surface and its binding to the c5b-7 complex triggers cytolytic signaling. in this study, c7 of rock bream (oplegnathus fasciatus) was identified (rb-c7) and characterized at the genomic level. the rb-c7 gene contains 18 exons and 17 introns and is composed of a 2490 bp complete open reading frame (orf). the encoded polypeptide (830 amino acids) contains a number of well-conserved c7 signature domains. i ...201323603298
invasin of edwardsiella tarda is essential for its haemolytic activity, biofilm formation and virulence towards fish.the aim of this study was to investigate the role of invasin in a bacterial fish pathogen edwardsiella tarda.201323600645
in vitro immunopathogenesis of edwardsiella tarda in catla catla catla (hamilton).immunopathogenesis of edwardsiella tarda in catla (catla catla) was evaluated by in vitro interaction of catla head kidney (hk) phagocytes with the bacterium. interactions of e. tarda with catla hk phagocytes were studied by light microscopy as well as by phagocytosis, intracellular replication, superoxide anion and nitric oxide production assays. both opsonised and non-opsonized bacteria could adhere to, survive and replicate within phagocytes. furthermore, there was no significant alteration i ...201323587681
proteomic analysis of a twin-arginine translocation-deficient mutant unravel its functions involved in stress adaptation and virulence in fish pathogen edwardsiella tarda.edwardsiella tarda is a gram-negative, facultative aerobic pathogen which infects multifarious hosts including fish, amphibians and human beings. a twin-arginine translocation (tat) gene cluster important for high-salt tolerance in e. tarda was identified previously. here the genetic structure and pleiotropic roles of the tat system in physiological adaptation of the bacterium were further characterized. functional analysis indicated that tatd was not required for tat export process and tate mig ...201323551118
complete genome sequence of a novel myovirus which infects atypical strains of edwardsiella tarda.we present the genome sequence of a novel edwardsiella tarda-lytic bacteriophage, msw-3, which specifically infects atypical e. tarda strains. the morphological and genomic features of msw-3 suggest that this phage is a new member of the dwarf myoviruses, which have been much less studied than other groups of myoviruses.201323469359
gene expression profiling in live attenuated edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish.despite the importance and success of vaccine immunization against bacterial diseases in fish, little is known about the molecular mechanisms of vaccine-induced immune protection in teleost fish. in this study, the live attenuated edwardsiella tarda vaccine strain wed, which has been shown to evoke efficacious protection against edwardsiellosis and ascites diseases in fish, was extensively evaluated for multiple parameters in a 5-week immunization and challenge experiment in zebrafish. the param ...201323434462
effects of dietary supplementation of citrus by-products fermented with a probiotic microbe on growth performance, innate immunity and disease resistance against edwardsiella tarda in juvenile olive flounder, paralichthys olivaceus (temminck & schlegel).two consecutive studies were conducted to evaluate the dietary supplementation of citrus by-products (cb) fermented with probiotic bacteria on growth performance, feed utilization, innate immune responses and disease resistance of juvenile olive flounder. in experiment i, five diets were formulated to contain 0% (control) or 3% four different cb fermented with bacillus subtilis (bs), enterococcus faecium (ef), lactobacillus rhamnosus (lr) and l. plantarum (lp) (designated as con, cbf-bs, cbf-ef, ...201323311661
presenting a foreign antigen on live attenuated edwardsiella tarda using twin-arginine translocation signal peptide as a multivalent vaccine.the twin-arginine translocation (tat) system is a major pathway for transmembrane translocation of fully folded proteins. in this study, a multivalent vaccine to present foreign antigens on live attenuated vaccine edwardsiella tarda wed using screened tat signal peptide was constructed. because the tat system increases the yields of folded antigens in periplasmic space or extracellular milieu, it is expected to contribute to the production of conformational epitope-derived specific antibodies. e ...201323994481
immune effects of a bivalent expressed outer membrane protein to american eels (anguilla rostrota).the specific and non-specific immune parameters and protection of american eels (anguilla rostrata) were evaluated after immunized eels with a bivalent expressed out membrane protein (omp) of porin ⅱ of aeromonas hydrophila and omps2 of edwardsiella tarda. one hundred eighty eels were distributed into 3 equal groups and intraperitoneal (i.p) injection with phosphate-buffered saline (pbs group), formalin-killed-whole-cell (fkc) of a. hydrophila and e. tarda (fkc group) or the bivalent omp (omp gr ...201323643876
asd-based balanced-lethal system in attenuated edwardsiella tarda to express a heterologous antigen for a multivalent bacterial vaccine.edwardsiella tarda is an enteric gram-negative invasive intracellular pathogen, which causes enteric septicemia in fish. it could be potentially used to develop a recombinant attenuated e. tarda vaccine for the aquaculture industry. because live vaccine strains can potentially be released into the environment upon vaccination, medical and environmental safety issues must be considered. deletion of the asdb gene in e. tarda resulted in a diaminopimelic acid (dap)-dependent mutant. the wild type a ...201323454428
[medical and technologic aspects of the manifestation of silicosis in workers in the prvomajska foundry, zagreb]. 20133842066
"what is," and "what should be?". 20133870712
the official opening of the s.a. nurses memorial centre. 20134498805
the official opening of the s.a. nurses memorial centre. 20134498805
edwardsiella tarda ivy, a lysozyme inhibitor that blocks the lytic effect of lysozyme and facilitates host infection in a manner that is dependent on the conserved cysteine residue.edwardsiella tarda is a gram-negative bacterial pathogen with a broad host range that includes fish and humans. in this study, we examined the activity and function of the lysozyme inhibitor ivy (named ivyet) identified in the pathogenic e. tarda strain tx01. ivyet possesses the ivy signature motif ckphdc in the form of (82)cqphnc(87) and contains several highly conserved residues, including a tryptophan (w55). for the purpose of virulence analysis, an isogenic tx01 mutant, txivy, was created. t ...201323817616
sialic acid utilization by cronobacter sakazakii.the cronobacter genus is composed of seven species, and can cause infections in all age groups. of particular concern is c. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and meningitis in neonates and infants. whole genome sequencing has revealed that the nanakt gene cluster required for the utilisation of exogenous sialic acid is unique to the c. sakazakii species (esa_03609-13).sialic acid is found in breast milk, infant formul ...201323706082
comparative genomics reveals that a fish pathogenic bacterium edwardsiella tarda has acquired the locus of enterocyte effacement (lee) through horizontal gene transfer.edwardsiella tarda is an enterobacterium which causes edwardsiellosis, a fatal disease of cultured fishes such as red sea bream, eel, and flounder. preventing the occurrence of e. tarda infection has thus been an important issue in aquaculture. e. tarda has been isolated from other animals and from many environments; however, the relationship between the genotype and evolutionary process of this pathogen is not fully understood. to clarify this relationship, we sequenced and compared the genomes ...201324053667
[the erythrocyte as a potential container for directed transport of drugs to damaged parts of the circulatory bed]. 20133707723
[research--the source of medical progress]. 20133842698
the in vivo extracellular life of facultative intracellular bacterial parasites: role in pathogenesis.classically labeled facultative intracellular pathogens are characterized by the ability to have an intracellular phase in the host, which is required for pathogenicity, while capable of extracellular growth in vitro. the ability of these bacteria to replicate in cell-free conditions is usually assessed by culture in artificial bacteriological media. however, the extracellular growth ability of these pathogens may also be expressed by a phase of extracellular infection in the natural setting of ...201322795971
theory on thermal probe arrays for the distinction between the convective and the perfusive modalities of heat transfer in living tissues.recent suggestions for an improved model of heat transfer in living tissues emphasize the existence of a convective mode due to flowing blood in addition to, or even instead of, the perfusive mode, as proposed in pennes' "classic" bioheat equation. in view of these suggestions, it might be beneficial to develop a technique that will enable one to distinguish between these two modes of bioheat transfer. to this end, a concept that utilizes a multiprobe array of thermistors in conjunction with a r ...20133695437
[choice of a calcium antagonist in chronic stable angina]. 20134093052
[medical care problems of patients with delayed consolidation]. 20133587953
attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin.in an attempt to develop attenuated bacteria as potential live vaccines, four chemicals (gossypol, proflavine hemisulfate, novobiocin, and ciprofloxacin) were used to modify the following four genera of bacteria through chemical-resistance strategy: (1) aeromonas hydrophila (9 isolates); (2) edwardsiella tarda (9 isolates); (3) streptococcus iniae (9 isolates); and (4) s. agalactiae (11 isolates). all bacteria used in this study were able to develop high resistance to gossypol. however, only som ...201323499519
antimicrobial and herbal drug resistance in enteric bacteria isolated from faecal droppings of common house lizard/gecko (hemidactylus frenatus).from 194 faecal dropping samples of common house geckos collected from offices (60), houses (88), integrated farm units (ifs,18) and hostels, guest houses, and dining rooms of different canteen/mess (hgm, 28), 326 bacterial isolates of enteric bacteria belonging to 17 genera and 34 species were detected. escherichia coli were the most frequently (39) isolated followed by citrobacter freundii (33), klebsiella pneumonia (27), salmonella indica (12), enterobacter gergoviae (12), and ent. agglomeran ...201324223595
dna vaccines: roles against diseases.vaccination is the most successful application of immunological principles to human health. vaccine efficacy needs to be reviewed from time to time and its safety is an overriding consideration. dna vaccines offer simple yet effective means of inducing broad-based immunity. these vaccines work by allowing the expression of the microbial antigen inside host cells that take up the plasmid. these vaccines function by generating the desired antigen inside the cells, with the advantage that this may ...201324432284
bacterial infections from aquatic species: potential for and prevention of contact zoonoses.as aquaculture production and the consumption of aquaculture products increase, the possibility of contracting zoonotic infections from either handling or ingesting these products also increases. the principal pathogens acquired topically from fish or shellfish through spine/pincer puncture or open wounds are aeromonas hydrophila, edwardsiella tarda, mycobacterium marinum, streptococcus iniae, vibrio vulnificus and v. damsela. these pathogens, which are all indigenous to the aquatic environment, ...201324547653
effects of potential probiotic bacillus amyloliquefaciens [corrected] fptb16 on systemic and cutaneous mucosal immune responses and disease resistance of catla (catla catla).effects of dietary administration of bacillus amyloliquefaciens fptb16 on systemic and mucosal immunity and disease resistance of catla (catla catla) against edwardsiella tarda infection were evaluated in the present study. the laboratory maintained b. amyloliquefaciens was used to study antagonistic activity against fish pathogenic bacteria by agar well diffusion assay. healthy catla were challenged by this bacterium for determination of its safety. for preparation of probiotic supplemented die ...201324012512
the temporomandibular joint from the viewpoint of the anatomist. 20133862765
[anomaly of clot formation in a case of igg myeloma. influence of the isolated paraprotein on coagulation and ultrastructural study of the clot]. 20134229320
[anomaly of clot formation in a case of igg myeloma. influence of the isolated paraprotein on coagulation and ultrastructural study of the clot]. 20134229320
quantitative analysis of tissue distribution of ly10-like murine alloantigen(s) with antisera and monoclonal antibodies.tissue distribution of non-lyt1.1 ("ly10-like") antigen or antigens encoded by short chromosomal segment differentiating b6-ly-1a congenic strain from b6 strain of mice was studied by quantitative absorption of (balb/c x b6)f1 anti b6-ly-1a antiserum and by direct cytotoxicity of ly-10-132-12-26 monoclonal antibody on lymphoid cell populations. identical strain but not tissue distribution pattern does not allow to conclude whether antiserum and monoclonal antibody detect the same or closely link ...20133800600
observer variability in the pulmonary examination.observer variability in the pulmonary examination was assessed by having four blindfolded observers (two medical students and two pulmonary physicians) twice examine 31 patients with abnormal pulmonary findings. examiners were consistent in the repetitive detection of pulmonary abnormalities in 74-89% of the examinations; conversely, 11-26% of the time they disagreed with themselves. although pulmonary specialists recorded fewer (55% of observations) abnormal findings than did medical students ( ...20133794835
[a case of idiopathic isolated tricuspid valve prolapse associated with tricuspid regurgitation]. 20134059682
[annual meeting 1984 of the society for hospital hygiene. the effectiveness of hospital hygiene measures]. 20133844553
identification and surveillance of individuals at high risk.inherent in any cancer detection program strategy is the identification and surveillance of groups at especially high risk, in that success can be expected to be highest and costs for positive case finding lowest. the epidemiologic concepts of sensitivity and specificity are of importance in such programs. among occupational groups, directed programs have started to demonstrate usefulness in altering outcome. for other types of exposure, some results have been disappointing, such as x-ray screen ...20133779704
adolescent versus adult thyroid carcinoma.several significant differences exist between adolescent and adult thyroid carcinoma. the incidence of malignancy in nodular goiter is higher in children than it is in adults. thyroid cancer in childhood and adolescence has a slightly lower predilection for female than for male subjects, as compared to adult patients. the younger patients have a predominance of well-differentiated carcinomas which are more likely to be papillary. the lesions in the young age group tend to be more advanced locall ...20133702570
transitional mucosa of the large intestine. 20134085987
[the role of a hospital, polyclinic and a specialized sanatorium in the rehabilitation of children with glomerulonephritis]. 20133696851
thymic involvement in acute disseminated histiocytosis x. 20133628861
[in vitro characterization of a group of aplastic anemias]. 20134023319
computer-aided diagnosis of dermatologic disorders.in conclusion, several computer programs have been developed to aid diagnosis in dermatology. these have used various methods to reach a diagnosis, with some earlier programs using probabilistic techniques and later programs using cognitive models. several current trends, if they continue, would indicate that computer-assisted diagnosis may play a greater role. the growing number of physicians who own the prerequisite computing resources will probably want diagnostic software to accompany their ...20133536227
[multivariate analysis of risk factors for low birth weight in live births in the municipality of são paulo, sp (brazil)]. 20133832376
computer system support. part ii. 20133846051
effects of increased cell mass and altered gene dosage on the timing of initiation of macronuclear dna synthesis in paramecium tetraurelia. implications for cell cycle regulation.in paramecium, cell mass and macronuclear dna content can vary substantially, and both variables affect the timing of initiation of macronuclear dna synthesis. cells normally begin macronuclear dna synthesis at 0.25 in the cell cycle when the mean cell mass is about 119% of the initial value. gene mutations were used to alter cell size by temporarily blocking cell cycle progression and to change dna content by altering the segregation pattern of macronuclear material to daughter nuclei at fissio ...20133709689
the role of the clinical environment in the translation of research into practice. 20133636224
[congress 86. there is nothing too small to be discussed]. 20133638012
successful pregnancy in primary glomerular disease.the course of 66 pregnancies was studied in 48 women with primary glomerular diseases. in all cases diagnoses were established by biopsy before pregnancy. they were: membranoproliferative glomerulonephritis in 16 patients, focal glomeruloesclerosis in 13, iga nephropathy in 10, membranous nephropathy in seven and focal glomerulonephritis in two women. the clinical status of the nephropathy before conception was that 43 had only mild renal dysfunction, five had moderate renal insufficiency, serum ...20133820941
[liver diseases and glycoregulation]. 20133811778
refinement of the solution structure of the dna hexamer 5'd(gcatgc)2: combined use of nuclear magnetic resonance and restrained molecular dynamics.the solution structure of the self-complementary dna hexamer 5'd(gcatgc)2 comprising the specific target site for the restriction endonuclease sph 1 is investigated by using nuclear magnetic resonance spectroscopy and restrained molecular dynamics. all the nonexchangeable proton resonances are assigned sequentially, and from time-dependent nuclear overhauser enhancement measurements a set of 158 approximate interproton distances are determined. these distances are used as the basis of a structur ...20133651407
laryngeal trauma vs length of intubation.the frequency histograms of six patients' laryngographs were studied pre- and post-endotracheal intubation. the changes were correlated with the length of intubation. the post-operative hoarse voice was seen as an increase in the spread of the lower frequencies, and an increase in the fundamental frequency. the latter change was thought to be a subconscious compensation for the hoarseness. the increased lower frequency spread as measured by standard deviation was directly proportional to the len ...20133694032
the medical devices adverse experience reporting project. 20133948035
the medical devices adverse experience reporting project. 20133948035
[cerebral hemorrhage in the premature neonate. report of 80 cases]. 20133792879
association-dissociation equilibria of octopus hemocyanin.the equilibria between the native (decameric) octopus hemocyanin and its subunits were studied by analytical sedimentation. equilibrium is obtained slowly, but the reaction is thermodynamically reversible. the mass action law for a monomer-decamer reaction is obeyed. the reassociated hemocyanin is virtually identical in its sedimentation behavior and oxygen binding with the native protein. the association-dissociation equilibria are mediated by cations; mg2+, ca2+, na+, and h+ are all effective ...20134063339
[effect of patient markers and interview procedures on admission to therapy--a catamnestic study of the initial psychotherapeutic interview].this investigation concerns the individual and institutional factors which play a role in the stratification of therapy and in the selection of patients. to this end, six to eight years after the initial interviews, a catamnestic investigation on one hundred patients was carried out at the giessen centre for psychosomatic medicine. identified as variables with a potential for influencing the further career of the patient were individual attributes of the patient and characteristic features of th ...20133716653
variations in the preservation of bank blood due to processing. 20134642160
variations in the preservation of bank blood due to processing. 20134642160
the value of stimulus detection for long periods in the diagnosis of spasmophilia. 20134188498
the value of stimulus detection for long periods in the diagnosis of spasmophilia. 20134188498
the cutting diathermy and drain tracts. 20133810377
the john scott memorial lecture 1985. space invaders. 20133749489
[dieulafoy disease. a rare cause of upper gastrointestinal hemorrhage]. 20133871983
[dieulafoy disease. a rare cause of upper gastrointestinal hemorrhage]. 20133871983
[multifocal hydatid cysts in children].from 1981 to 1983, 112 children have been operated on for hydatidosis, 26 of them presented multifocal hydatid cysts. in half cases the lung was affected, in association with an abdominal affect. in 6 cases it was a bilateral pulmonary localisation. the check-up is essentially with two exams: thoracal radiology, front and side view; and abdominal echography. the hydatic serology confirms the parasitic origin. 40 surgical operations have been necessary for 21 children carried 171 hydatid cysts. t ...20133719886
ruptured abdominal aortic aneurysms: experience with 70 cases.during the period 1965-1983, 270 patients underwent resection of abdominal aortic aneurysm. in 70 patients (26%) the aneurysm was ruptured. overall hospital mortality of patients with ruptures was 34%. five patients died before the graft could be completed. common denominators associated with mortality were hypotension, renal failure, cardiac arrest, and postoperative hemorrhage. the average age over the first 10 years was 68, but subsequently, has risen gradually, with a corresponding increase ...20134028537
ruptured abdominal aortic aneurysms: experience with 70 cases.during the period 1965-1983, 270 patients underwent resection of abdominal aortic aneurysm. in 70 patients (26%) the aneurysm was ruptured. overall hospital mortality of patients with ruptures was 34%. five patients died before the graft could be completed. common denominators associated with mortality were hypotension, renal failure, cardiac arrest, and postoperative hemorrhage. the average age over the first 10 years was 68, but subsequently, has risen gradually, with a corresponding increase ...20134028537
development of a multiplex pcr for the identification of pathogenic edwardsiella tarda and application to edwardsiellosis diagnostics. 201323126448
identification of antigenic edwardsiella tarda surface proteins and their role in pathogenesis.edwardsiella tarda causes an infectious fish disease called edwardsiellosis. several outer membrane proteins (omps) are associated with virulence factors and are attractive as vaccine candidates. in this study, 4 immuno-reactive omps of e. tarda were detected using anti-sera from flounder infected with e. tarda. using matrix-assisted laser desorption/ionization mass spectrometry analyses, 2 of the 4 omps were identified as ompa and murein lipoprotein (lpp), which are highly conserved surface pro ...201323231854
triple arthrodesis. a critical long-term review.the results of triple arthrodesis performed in 80 feet and followed for an average of 13 years are reviewed. although the majority of patients were very pleased, the results of objective assessment were less favourable. there was a high incidence of degenerative joint changes in the ankle and midfoot and also of pseudarthrosis, avascular necrosis of the talus and residual deformity. pre-operative rigid equinovarus deformity produced the majority of the poor results. it is suggested that bony res ...20143958012
prof. frits grewel, 1898-1973. 20144601331
typology of male-to-female transsexualism.this study tested a prediction derived from the hypothesis that asexual and bisexual transsexualism are actually subtypes of heterosexual transsexualism. two questionnaire scales measuring erotic attraction to males and females were administered to 163 male-to-female transsexuals. a cluster analysis of their scores divided the subjects into four groups: heterosexual, homosexual, bisexual, and asexual. fisher exact tests were used to compare the frequency with which subjects in the four clusters ...20144004548
tissue immunity and organ transplantation. 20144172388
automatic external defibrillation: bringing it home. 20144063027
activities of the modified polyene n-d-ornithyl amphotericin methyl ester and the azoles ici 153066, bay n 7133, and bay l 9139 compared with those of amphotericin b and ketoconazole in the therapy of experimental blastomycosis.we studied the efficacy of new experimental antifungal drugs, which represent molecular modifications of present active agents, in a murine model of blastomycosis. ketoconazole, previously the best azole drug studied and which is protective when administered orally, was superior to a new oral imidazole, bay l 9139, and a new oral triazole, bay n 7133. a new oral triazole, ici 153066, was markedly more effective than ketoconazole and is the only oral drug studied which came close to producing com ...20143994350
toxicokinetics of lithium intoxication treated by hemodialysis.a 66-year old female on long-term lithium therapy, developed neurologic toxicity with coma and convulsions. the treatment consisted artificial ventilation, fluid and electrolyte infusions and a six hour hemodialysis (hd) on days 2, 3 and 4. the convulsions disappeared on day 4; the patient regained consciousness on day l2 and recovered with slight sequelae. toxicokinetic studies were conducted for a period of 12 days. the lithium (li) serum concentration fell from 4.4 mmol/l on admission to 2.16 ...20143938485
[medical education in the 18th century. on the 325th anniversary of the birth of friedrich hoffmann (1660-1742)].the 325th anniversary of friedrich hoffmann's birthday gave rise to remind of the early high period of the faculty of medicine of halle university. several significant scientific achievements are connected with hoffmann's name, but at the same time also the organisation of studies and examinations in halle. the educational practices of his time were demonstrated with the help of preserved documentations.20143904240
effects of hydralazine on pressure-volume and stress-volume relations in congestive heart failure secondary to idiopathic dilated cardiomyopathy.the mechanism by which hydralazine improves cardiac function in patients with heart failure is not well characterized. hydralazine may improve left ventricular (lv) function by decreasing afterloading wall stress or by increasing myocardial contractility. the effect of intravenous hydralazine was assessed in 8 patients with severe idiopathic dilated cardiomyopathy. hydralazine increased stroke volume index (from 24 +/- 8 to 40 +/- 9 ml/m2, p less than 0.01) and decreased systemic vascular resist ...20144050708
prison-psychiatry: medical or correctional discipline? 20144010493
[a case of primary adenocarcinoma of the cervix of probable origin from an area of endometriosis].a case of primary adenocarcinoma of the cervix of probable endometrial origin is described in a 37 year-old woman.20143974935
low doses of progestogen as an approach to fertility control. 20144158852
what is visual training: a patient education handout. 20143968385
receptive-field symmetry probed using converging gratings.contrast-sensitivity functions (csf's) for converging and diverging gratings were obtained under voluntary fixation at several field widths and under retinal stabilization at one field width. in general, these types of gratings had similar csf's at all temporal frequencies tested, a result that can be explained by plausible spatiotemporal receptive-field models possessing spatial antisymmetry but not by models possessing pure (even) spatial symmetry. phase condition at the central line in conver ...20143973760
[mechanisms of adaptation to physical exertion in patients with an expiratory obstructive syndrome]. 20144096445
hypertrophy of heart with outflow tract obstruction and myocardial necrosis in an infant with multiple congenital malformations. 20144252909
identification of the bicarbonate secretory cell of the turtle bladder.the turtle bladder consists primarily of two mucosal cell types, mitochondrial rich (mr) and granular (g) cells. the mr cells secrete h+. in addition, the bladder secretes hco3-, an energy-requiring cl(-)-dependent transport system. these studies were designed to identify the cell type responsible for hco3- secretion. specific hco3- and h+ secretory inhibitors were added to alter o2 consumption of mr and g cells. cells were separated by ficoll density centrifugation. ouabain (10(-4) m) was used ...20144073269
relationship of eeg background rhythms to photic evoked responses. 20144157834
[carpal tunnel syndrome in dialysis patients]. 20144022204
[rare tumors of the iris and ciliary body. i]. 20144187762
[metabolism of malignant melanomas. biochemical studies]. 20144346243
cretinism with muscular hypertrophy (kocher-debré-sémélaigne syndrome). histochemical and ultrastructural study of skeletal muscle. 20144097646
[paget's disease of the nipple and mammary epithelioma. importance of mammography in diagnosis]. 20144294240
[paget's disease of the nipple and mammary epithelioma. importance of mammography in diagnosis]. 20144294240
selective surgical management of neural tube malformations.the physical characteristics of 49 children with spina bifida cystica, survivors of a group subjected to selection for early surgery are compared with 39 children alive from an earlier unselected series, born in the 1960s, and reviewed retrospectively. sixteen children were also studied in whom the initial decision not to operate had been followed by survival and subsequent treatment. children selected for initial surgery have a significantly lower mortality than those not selected and their mob ...20144015145
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