Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| lyme borreliosis in romania. | 1988 | 3202685 | |
| lyme disease in italy: isolation of borrelia burgdorferi from a patient. | a strain of borrelia burgdorferi was isolated from a 48-year-old female patient suffering from a chronic form of polyarthritis. significant titers of specific anti-borrelia antibodies were not found. this is the first report of isolation of borrelia burgdorferi from a patient in italy. | 1988 | 3203735 |
| seroconversion to borrelia burgdorferi in a patient with juvenile arthritis in ontario, canada. | a seroconversion to borrelia burgdorferi, the etiological agent of lyme disease, was documented in a 5 year old girl from central ontario. our patient developed juvenile arthritis in january, 1984 when she was 14 months old. it was relatively well controlled with aspirin. her arthritis flared in april, 1986 at which time seroconversion to b. burgdorferi was demonstrated by indirect immunofluorescence and by enzyme linked immunosorbent assay. she was treated with phenoxymethyl penicillin and has ... | 1988 | 3204603 |
| [antibody activity of csf oligoclonal igg in infectious neurological diseases. detection using immunoblotting]. | the authors describe various applications of an immunoblot technique which allows the qualitative determination of the specific antibody activity of oligoclonal igg intrathecally synthesized in infectious diseases of the nervous system. after dilution of sera to the same igg concentration as the paired csf samples, 10 microliters of both fluids are applied side by side on agarose gel plates and isoelectrically focused. precipitated igg or specific igg antibodies are then blotted onto a nitrocell ... | 1988 | 3206996 |
| the significance of eperythrozoon ovis in ill-thrift in sheep in the eastern cape coastal areas of south africa. | ill-thrift in sheep in the coastal region of the eastern cape is described. it is shown to be a complex problem attributable to many causes, most of which can be eliminated by supplementary feeding, drenching, vaccination, dipping and management. however, studies on the aetiology of ill-thrift in young sheep indicate that arthropod-borne anaemia-producing pathogens are an important contributing factor, which cannot readily be diagnosed and controlled. experiments were conducted on various farms ... | 1988 | 3210217 |
| first isolation of borrelia burgdorferi, the agent of lyme borreliosis, from ixodes ricinus (acari: ixodidae) in berlin (west). | in 1984, two human cases of tick-borne lyme borreliosis with considerable neurologic involvement were reported in berlin (west). the diagnosis of lyme borreliosis was serologically confirmed. the ticks which had transmitted the borrelia were from berlin (west). in the autumn of 1985, 156 ticks were collected in forests of berlin (west) for the cultural detection of spirochetes by using bsk ii medium. three strains of spirochetes were isolated (from a pooled sample of two nymphs, and samples of o ... | 1988 | 3213319 |
| infections following tickbites. tick-borne encephalitis and lyme borreliosis--a prospective epidemiological study from tyrol. | we present here a prospective study on infections following tickbites in military recruits in the province of tyrol (austria). 84 recruits experienced tickbites and underwent clinical and serological examination twice at four-week intervals for signs of tick borne encephalitis (tbe)-virus or borrelia burgdorferi infections. 56 and 50 recruits could be evaluated for tbe-virus and borrelia infection, respectively. whereas no recruit was found with clinical or laboratory evidence of tbe-virus infec ... | 1988 | 3215687 |
| [the effectiveness of ciprofloxacin in bacterial skin infections]. | ciprofloxacin in a low dosage of 250 mg twice a day was applied in the treatment of bacterial infections of the skin. all cultured staphylococci, streptococci, and pseudomonas proved to be highly sensitive to ciprofloxacin. the cases of pyoderma showed quick healing, but there were relapses of lyme borrelia within 6 weeks. as the titers of igm and igg steadily increased during the following months, additional therapy was necessary. the tolerance of ciprofloxacin was generally very good. | 1988 | 3218288 |
| lyme disease meningopolyneuritis simulating malignant lymphoma. | lyme disease is a multisystem disorder resulting from infection by the tick-borne spirochete, borrelia burgdorferi. fever, chills, malaise and headaches; a characteristic rash; and subsequent polyarthritis typically herald the onset of this condition. neurologic involvement may occur with skin and joint manifestations or present alone as meningitis, cranial neuritis, and radiculopathy known as bannwarth's syndrome. we report the cerebrospinal fluid (csf) cytomorphologic and immunocytochemical fe ... | 1988 | 3222255 |
| [neuroborreliosis]. | the principles of certain clinical symptoms first described at the beginning of the century are rediscovered again: erythema chronicum migrans after tick-bite followed by numerous neurological manifestations. meningopolyneuritis garin-bujadoux-bannwarth is recognized to be a central nervous system-manifestation of borrelian infection transmitted by tick-bites. in a period of 2 years we evaluated 15 patients with diagnosis neuroborreliosis. there is a good improvement after treatment with penicil ... | 1988 | 3222964 |
| borrelia burgdorferi antibodies in patients with relapsing/remitting form and chronic progressive form of multiple sclerosis. | sera of 106 multiple sclerosis patients and 103 closely matched controls were examined for borrelia burgdorferi antibodies. the prevalence rate in multiple sclerosis patients was 14.2%, in controls 25.2%. overall prevalence was 20.1%. mean igg antibody level was insignificantly higher in controls than in multiple sclerosis patients. patients with a chronic progressive course of multiple sclerosis had an insignificantly higher mean borrelia antibody level, when compared with those suffering from ... | 1988 | 3225603 |
| complete heart block in a dog seropositive for borrelia burgdorferi. similarity to human lyme carditis. | lyme disease has been recognized in humans since 1975 when it was associated with an outbreak of oligoarthritis in children in lyme, connecticut. erythema chronicum migrans (ecm) is a clinical marker for the human disease, which usually appears within 3 to 32 days after an infected tick bite. lyme disease is caused by spirochete, borrelia burgdorferi, which is vectored by the hard ticks ixodes dammini or ixodes pacificus in the united states. in humans, lyme disease has been found to cause a var ... | 1988 | 3225808 |
| borrelia infection in patients with vertigo and sensorineural hearing loss. | tick-borne borrelia infection gives rise to symptoms from different organs. neurologic manifestations are common. the aim of this study was to evaluate to what extent the cochleovestibular functions are involved in this disease. a total of 73 patients with vertigo were studied. the patients had meniere-like conditions, positional vertigo or unilateral loss of the vestibular function. antibodies in serum to the borrelia spirochete were determined in the acute and convalescent periods. ten patient ... | 1988 | 3227270 |
| cns-borreliosis selectively affecting central motor neurons. | a patient is described having borrelia burgdorferi spirochetal infection clinically affecting central motor neurons selectively and without any sensory impairment. diagnosis was based on elevated b. burgdorferi igg antibody titers in cerebrospinal fluid (csf) and titer normalization at clinical recovery. this occurred promptly and was complete after penicillin treatment despite 14 months of progressive central nervous system (cns) dysfunction, favouring the hypothesis of the presence of the orga ... | 1988 | 3227803 |
| [transmission of borrelia burgdorferi from nymphs to imago in the tick ixodes persulcatus schulze]. | 1988 | 3229314 | |
| borrelia burgdorferi infection surrounding la crosse, wis. | this investigation defined the extent of borrelia burgdorferi infection surrounding la crosse, wis. white-footed mice, peromyscus leucopus or p. maniculatis, were captured from sites in wisconsin, minnesota, and iowa and cultured for b. burgdorferi to define the local boundaries of the midwestern lyme disease area. all foci of b. burgdorferi infection (n1, n2, n3, and n4) were located north of interstate highway 90 except focus s2, which was south of the highway near fort mccoy, wis. the interst ... | 1988 | 3230137 |
| imported case of bannwarth's syndrome (chronic lymphocytic meningoradiculitis or lyme meningitis). | 1988 | 3233679 | |
| [acrodermatitis chronic atrophicans and sclerodermiform skin changes in borrelia infection]. | a female patient with acrodermatitis chronica atrophicans and widespread sclerodermiform skin lesions with a high igg antibody titer against borrelia burgdorferi is presented. the rapid improvement after high-dose penicillin g therapy and the course of the borrelia antibody titer suggest a persistence of the causative organism. | 1988 | 3235338 |
| heterogeneity in immunoblot patterns obtained by using four strains of borrelia burgdorferi and sera from naturally exposed dogs. | this study evaluated the differences in immunoblot patterns when serum specimens from seropositive dogs were reacted against four strains of borrelia burgdorferi. intense bands were consistently detected for the 83-, 66-, 61- to 60-, 41-, and 31-kilodalton regions for all four strains. most variations were observed in the regions of 45 to 34 and 26 to 15 kilodaltons. adsorption studies suggested that one reason for the observed variability was a difference in proteins among the organisms, rather ... | 1988 | 3235655 |
| acquired transient autoimmune reactions in lyme arthritis: correlation between rheumatoid factor and disease activity. | lyme spirochaetal disease (lsd) is a complex multisystem disorder which has been recognized as a separate entity due to its close geographic clustering of affected patients. the study aimed at evaluating the clinical and immunological features of lsd with chronic symptoms of meningoradiculitis, carditis and pauciarticular arthritis. six patients with lsd and erosive arthritis who developed an increase of serum igm rheumatoid factor (rf) which correlated with the inflammatory activity of the dise ... | 1988 | 3238365 |
| [determination of serum antibody to burgdorferi spirrila and its clinical application in lyme disease]. | 1988 | 3242760 | |
| [cerebrospinal fluid cytologic findings in children with borrelia infections (neuroborreliosis)]. | the infection of the central nervous system by borrelia burgdorferi induces usually a mononuclear (lympho-mono-plasmocellular) cytogram of the cerebrospinal fluid in humans. the initial granulocytosis of the liquor cerebrospinalis typical for bacterial infections is transistory only. such cytologic findings may be misleading to a diagnosis as virus infection. in case of clinical signs (bannwarth syndrome), typical anamnesis or chronic lymphocytic meningitis the estimation of specific igg/igm bor ... | 1988 | 3244809 |
| [the clinical and serologic investigation in 15 cases of lyme disease]. | 1988 | 3246194 | |
| segmented arrangement of borrelia duttonii dna and location of variant surface antigen genes. | the dna of an isolate of borrelia duttonii, an agent of relapsing fever is present as seven major species ranging in size from 10 kb to greater than 150 kb. additionally, this isolate contains low copy number species, both smaller and larger than these seven major elements. no one of these individual dna species obviously corresponds to the bacterial chromosome, unlike the situation in borrelia hermsii, another relapsing fever borrelia. thus it appears that b. duttonii has a unique segmented arr ... | 1988 | 3246585 |
| [etiologic diagnosis of cases of autochthonous borrelia burgdorferi infection (lyme disease)]. | 1988 | 3249895 | |
| [spirochetes isolated from the blood of three cases of lyme disease with neurologic abnormalities]. | 1988 | 3250099 | |
| [erythema chronicum migrans caused by borrelia burgdorferi]. | 1988 | 3251480 | |
| lyme borrelia positive serology associated with spontaneous abortion in an endemic italian area. | lyme borreliosis acquired during pregnancy may be associated with stillbirth and fetal malformations. this paper reports preliminary results of a study intended to evaluate the frequency of borrelia burgdorferi infection associated with spontaneous abortion in an endemic italian area. | 1988 | 3252658 |
| clinical presentation of louse-borne relapsing fever among ethiopian refugees in northern somalia. | louse-borne relapsing fever (lbrf) is still endemic among ethiopian populations. in order to assess the clinical presentation of lbrf in an ethiopian refugee camp in northern somalia, a referral system was organized for all pyrexias of unknown origin. among the 134 patients referred, 37 showed borrelia in fresh and stained blood smears. common clinical features were: high fever (above 39 degrees c in 73% of the cases), headache and general body pain (88%), liver tenderness (62%), petechia (54%), ... | 1988 | 3257078 |
| experimental lyme arthritis in rats infected with borrelia burgdorferi. | 1988 | 3258003 | |
| spirochetal antigens and lymphoid cell surface markers in lyme synovitis. comparison with rheumatoid synovium and tonsillar lymphoid tissue. | using monoclonal antibodies to spirochetal antigenes and lymphoid cell surface markers, we examined the synovial lesions of 12 patients with lyme disease, and compared them with rheumatoid synovium and tonsillar lymphoid tissue. the synovial lesions of lyme disease patients and rheumatoid arthritis patients were similar and often consisted of the elements found in normal organized lymphoid tissue. in both diseases, t cells, predominantly of the helper/inducer subset, were distributed diffusely i ... | 1988 | 3258751 |
| in vivo and in vitro evidence of b cell hyperactivity during lyme disease. | in vitro igm production by cells from patients with lyme disease rose during the illness in those studied soon after onset, but fell from elevated levels in those initially studied later than 1 week after onset. borrelia burgdorferi stimulated normal and patients' cells produced igm, with cells from acutely ill patients producing the most; production fell during convalescence. patients with active lyme disease and those destined for later manifestations often had serum agglutinins for heterologo ... | 1988 | 3260952 |
| immunoglobulin g subclasses specific to borrelia burgdorferi in patients with lyme disease. | 1988 | 3263825 | |
| lyme borreliosis in california. acarological, clinical, and epidemiological studies. | the relative abundance of, and spirochetal-infection rates in, adult ixodid ticks from eight lyme borreliosis clinical-case areas and two comparison areas were investigated in northern california from late fall to early spring, 1984-87. the western black-legged tick (ixodes pacificus) was the most abundant species at seven of nine sites yielding specimens as determined with a tick drag method. the pacific coast tick (dermacentor occidentalis) was the most abundant species at two sites, and lesse ... | 1988 | 3263826 |
| an animal model for lyme arthritis. | a model of lyme arthritis has been developed in laboratory rats. intraperitoneal inoculation of a low-passage tick isolate of b. burgdorferi into neonatal and weanling lew/n rats resulted in multisystemic infection and arthritis. spirochetes were isolated from blood, liver, kidney, spleen, brain, and joints of inoculated rats. arthritis, associated with the presence of spirochetes, developed in multiple joints by day 14 and persisted through day 90 after inoculation. arthritic lesions resembled ... | 1988 | 3263827 |
| the role of interleukin-1 in the pathogenesis of lyme disease. | 1988 | 3263828 | |
| specific immune responses in lyme borreliosis. characterization of t cell and b cell responses to borrelia burgdorferi. | 1988 | 3263829 | |
| association of hla-dr2 antigen with serum igg antibodies against borrelia burgdorferi in bannwarth's syndrome. | the frequency of the hla-dr2 antigen in 33 patients with clinical symptoms and signs of bannwarth's syndrome was 33%, which was not significantly different from the 29% occurrence in 505 control subjects. however, all 11 hla-dr2-positive patients had elevated serum levels of igg antibodies against borrelia burgdorferi, and these were present in 45% of 22 hla-dr2-negative patients (p = 0.004). in the 21 patients with anti-b. burgdorferi antibodies the frequency of hla-dr2 was 52%, which is signif ... | 1988 | 3265432 |
| borrelia burgdorferi--specific and autoreactive t-cell lines from cerebrospinal fluid in lyme radiculomyelitis. | in 3 patients with lyme radiculomyelitis, cellular immune reactions of cerebrospinal fluid (csf) lymphocytes were analyzed. phenotypic analysis of csf cells demonstrated that the majority were t cells (cd3+) of the helper/inducer subset (cd4+). these t cells were directly expanded from the csf by limiting dilution. a total of 505 t-cell lines were tested for borrelia burgdorferi (bb)-specific proliferation and also partly tested for reactivity to a panel of central and peripheral nervous system ... | 1988 | 3266455 |
| immunoperoxidase slide test for detecting antibodies to borrelia burgdorferi. | 1988 | 3275724 | |
| lyme disease and its neurologic complications. | lyme disease is recognized as a cause of illness involving multiple organ systems. the transmission of the borrelia burgdorferi spirochete depends on a complicated vector life cycle, involving multiple mammalian and avian hosts. although the illness is reported worldwide, variable clinical presentations on different continents raise questions about disease mechanisms. multiple neurologic syndromes can occur alone or in combination, producing peripheral neuropathies, radiculopathies, myelopathies ... | 1988 | 3276302 |
| role of immunoglobulin g in killing of borrelia burgdorferi by the classical complement pathway. | the antibody and complement requirements for killing of borrelia burgdorferi 297 by normal human serum (nhs) and nhs plus immunoglobulin g (igg) were examined. b. burgdorferi activated both the alternative and classical complement pathways in nhs. in nhs chelated with 10 mm ethylene glycol-bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid plus 4 mm mgcl2 (mg-egta) to block classical pathway activation, consumption (activation) of total hemolytic complement, complement component 3 (c3), and c ... | 1988 | 3276623 |
| comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparations for diagnosing early lyme disease. | we compared immunoblotting and indirect enzyme-linked immunosorbent assay (elisa) using different antigen preparations to test for antibody to borrelia burgdorferi in patients with early lyme disease. with immunoblotting, 16 (53%) of 30 patients had positive tests in acute-phase sera and 25 (83%) had them in convalescent-phase sera. among 64 controls, false-positive results were obtained in only three individuals with syphilis and in one hospitalized patient with renal allograft rejection. among ... | 1988 | 3279140 |
| spirochetes in mammals and ticks (acari: ixodidae) from a focus of lyme borreliosis in california. | in northern california, antibodies to borrelia burgdorferi were detected in 58 of 73 (79%), and spirochetemias in one of 26 (4%) black-tailed jackrabbits (lepus californicus californicus), by indirect and direct immunofluorescence, respectively. five species of ticks (dermacentor occidentalis, d. parumapertus, ixodes neotomae, i. pacificus, and haemaphysalis leporispalustris) were collected from rabbits. two of these species of ticks were found to contain spirochetes; two of 10 (20%) i. neotomae ... | 1988 | 3280837 |
| borreliosis in equids in northeastern united states. | during 1982 and 1985, blood samples from 705 equids were examined for antibodies to borrelia burgdorferi. by indirect immunofluorescence staining, igm and total immunoglobulin (igm and igg) antibodies were detected in 37 (5.3%) and 90 (12.8%) serum specimens, respectively. the geometric mean titer for igm antibody (140.4) was highest during july, whereas total immunoglobulin ranged from 94.1 in october to 338 in may. eighty-six equids with total immunoglobulin to b burgdorferi lived in areas of ... | 1988 | 3282461 |
| borrelia burgdorferi borreliosis. | 1988 | 3284861 | |
| [early summer meningoencephalitis, rickettsial diseases, borrelia infections: diseases carried by ticks]. | 1988 | 3287111 | |
| antibodies to borrelia burgdorferi in dogs in north carolina. | an indirect immunofluorescence assay was used to detect antibodies against borrelia burgdorferi in sera from 600 dogs in 1983 and 402 dogs in 1985. in 1983, the overall prevalence rate of dogs with b burgdorferi titers greater than or equal to 1:64 was 3.6%, whereas in 1985, the prevalence rate was 2.7%. an unexplainable higher seroprevalence was detected in 1 group of dogs tested in 1983. these dogs were from the southern coastal plains of north carolina. in the dogs tested in 1985, this region ... | 1988 | 3288020 |
| [the spectrum of lyme borreliosis from the dermatologic viewpoint]. | erythema chronicum migrans, lymphadenosis benigna cutis and acrodermatitis chronica atrophicans represent the dermatological manifestations of the multi-organ disease lyme borreliosis. koch's requirements of evidence for an infectious disease, demonstration of the bacterium, transfer, and culture have proven borrelia burgdorferi to be the causative agent of the above mentioned skin diseases. this justifies a penicillin therapy, that has been administered in europe empirically for the last 30 yea ... | 1988 | 3289873 |
| the urinary bladder, a consistent source of borrelia burgdorferi in experimentally infected white-footed mice (peromyscus leucopus). | white-footed mice, peromyscus leucopus, were experimentally infected in the laboratory with borrelia burgdorferi, the causative agent of lyme disease. after mice were infected by intraperitoneal or subcutaneous inoculation or by tick bite, attempts were made to culture spirochetes from the urinary bladder, spleen, kidney, blood, and urine. spirochetes were most frequently isolated from the bladder (94%), followed by the kidney (75%), spleen (61%), and blood (13%). no spirochetes were isolated fr ... | 1988 | 3290239 |
| use of an autologous antigen in the serologic testing of patients with erythema migrans of lyme disease. | we attempted to detect an early rise in antibody titers to borrelia burgdorferi in the serum of patients with erythema migrans of lyme disease by utilizing b. burgdorferi isolates obtained from patients' own skin lesions instead of the b31 reference strain. b. burgdorferi was isolated from nine of 23 skin biopsy specimens submitted for culture. elevated antibody titers were not detected in any of the 23 acute serum samples by immunofluorescence assay. the antigens derived from patient isolates w ... | 1988 | 3290287 |
| [tick-borne borrelia burgdorferi--frequent causative agent of peripheral facial paralysis]. | 1988 | 3290791 | |
| lyme disease: the latest great imitator. | lyme disease is caused by the spirochete b. burgdorferi. like its counterpart syphilis, it causes multisystem disease particularly affecting the skin, nervous system, heart and musculoskeletal system. it is endemic in several areas of the united states as well as in europe. the prompt recognition of this disease and its diverse manifestations should lead to early treatment and resolution. prevention is aimed at avoidance of the tick vector. | 1988 | 3292999 |
| a murine igm monoclonal antibody binds an antigenic determinant in outer surface protein a, an immunodominant basic protein of the lyme disease spirochete. | a hybridoma cell line formed by the fusion of the p3x63-ag8.653 myeloma cell line with splenocytes from balb/c mice immunized with borrelia burgdorferi produced an igm monoclonal antibody (mab-11g1) with kappa-light chains which detected an antigenic determinant in a major spirochetal protein of m.w. approximately 31,000, also known as outer surface protein a (osp-a). apparent saturation was reached in approximately 35 min with 34 ng of mab-11g1 binding to 5 x 10(7) spirochetes giving an estimat ... | 1988 | 2447170 |
| [primary lymphoma of the nervous system following radiculoneuritis caused by borrelia burgdorferi: study of a case]. | a 50-year-old man had a primary lymphoma of the central nervous system one year after a tick bite and a radiculoneuritis secondary to borrelia burgdorferi infection. determination of antibodies against borrelia burgdorferi revealed increasing igm and igg titers, and the autopsy showed a primary b-cell immunoblastic lymphoma of the brain without evidence of extraneural lymphoproliferative disorder. lymphoma of the brain is a rare type of central nervous system cancer, and sporadic cases appear wi ... | 1988 | 2451279 |
| biological activity of borrelia burgdorferi antigens. | osp-a (approximately 31 kda) and flagellins (approximately 41 kda) are prominent antigens of borrelia burgdorferi. both osp-a and flagellins are immunogenic in patients and in experimentally infected mice and hamsters, but the kinetics of antibody formation to each vary considerably between the species. the role of eluted osp-a and flagellins in the cellular immune response, chemotaxigenesis, and cytoadherence was measured. eluted osp-a and flagellins stimulated the proliferation of normal and i ... | 1988 | 2461134 |
| antigenic variability of borrelia burgdorferi. | borrelia burgdorferi strains (six isolates from north america and 28 isolates from europe) were analyzed by physicochemical and immunological methods. by sds-page, all borrelia burgdorferi strains tested had two major proteins with constant molecular weights of 60 and 41 kda and one, two, or three variable low molecular weight proteins (ospa = 30-32 kda, ospb = 34-36 kda, pc = 21-22 kda). all combinations--except ospb alone or ospb/pc--were observed. borrelia burgdorferi strains were different f ... | 1988 | 2461135 |
| [lyme disease--a new infection from natural foci]. | 1988 | 2965619 | |
| [guillain-barré syndrome with favorable outcome in a case of recent human immunodeficiency virus infection]. | an acute polyradiculoneuropathy occurred in a 30 years homosexual male. e.l.i.s.a. test and western blot showed recent infection by h.i.v. besides, endogenous reinfestation by cytomegalovirus was found: high concentrations of specific igg antibodies and presence of the virus in the blood. t4 helper cells were severely reduced, without any other sign of cellular immunity failure. none of the two viruses was found in the nervous biopsy. this guillain-barre syndrome with a subsequent cellular react ... | 1988 | 2831607 |
| immunochemical characterization of and isolation of the gene for a borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of bacteria. | by crossed immunoelectrophoresis and western blotting (immunoblotting), it was shown that borrelia burgdorferi expresses the 60-kilodalton common antigen (ca) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. b. burgdorferi ca is strongly immunogenic. a b. burgdorferi genomic library was constructed by using a plasmid cloning system. escherichia coli recombinants were screened for expression of immunodominant b. burgdorferi antigens. one of the recom ... | 1988 | 2840400 |
| [report of a rare flat hemangioma]. | 1988 | 2841699 | |
| borrelia burgdorferi infection: a neurologist's perspective. | 1988 | 2847620 | |
| [identification and initial results of the study of lyme disease in northwestern ussr]. | 1988 | 2966893 | |
| [serologic examination of convalescents and members of their families in tick-borne central asian borreliosis]. | 1988 | 2973554 | |
| [current epidemiology of central asiatic tick-borne borreliasis (based on the example of the fergana region)]. | 1988 | 2976473 | |
| [comparative evaluation of 2 methods for demonstrating borrelia in ticks--the vectors of lyme disease]. | 1988 | 2978047 | |
| demonstration of antigen-specific t cells and histopathological alterations in mice experimentally inoculated with borrelia burgdorferi. | antigen-specific t-cell responses and histopathological changes were studied in mice experimentally inoculated with borrelia burgdorferi b31. inbred mice with different h-2 haplotypes and/or different genetic backgrounds were inoculated with b. burgdorferi organisms and tested for antigen-specific t-cell responses in vivo (delayed-type hypersensitivity [dth]) and in vitro (t-cell proliferation). comparable dth responses were found after inoculation with either inactivated (in the presence of adj ... | 1989 | 2462540 |
| lyme disease. | lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. as more arthropod hosts throughout the world are infected with the causative organism, borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible animals is increasing. the neurological manifestations include acute and chronic forms, and it has become clear that b. burgdorferi has joined treponema pallidum, herpes simplex virus ... | 1989 | 2472690 |
| shared flagellar epitopes of borrelia burgdorferi and borrelia anserina. | antigenic cross-reactivity between borrelia burgdorferi and borrelia anserina was studied using mouse immune sera and monoclonal antibodies. with immune sera, significant cross-reactivity between b. burgdorferi and b. anserina was demonstrated by indirect immunofluorescent assay. in immunoblots, most of the cross-reactivity was shown to be associated with the periplasmic flagella. using monoclonal antibodies in immunoblots, it was shown that b. burgdorferi and b. anserina shared at least two fla ... | 1989 | 2473569 |
| immune responses to borrelia burgdorferi in patients with reactive arthritis. | in reactive arthritis (rea), including reiter's syndrome, a close relationship between chronic enteric and genitourinary infections and the clinical features of enthesitis has been described. in contrast, in lyme arthritis, a distinct clinical entity, chronic infection with the tick-transmitted spirochete borrelia burgdorferi has been associated with the disease. in a prospective study, 51 patients with rea were tested for evidence of chlamydial and spirochetal infection. the presence of chlamyd ... | 1989 | 2476133 |
| [effect of borrelia--the causative agent of tick-borne relapsing fever--on the vector]. | direct or indirect evidence of pathogenic effect of borrelia sogdiana, a tick-borne recurrent fever causative agent, on ornithodoros papillipes is obtained, pointing to a parasitic character of their relations. differences between infected and uninfected ticks are revealed both under normal life conditions (lower survival, more intensive process of moult), as well as under the effect of poison. higher sensitivity of infected ticks to ddt was established experimentally; hcch effect was determined ... | 1989 | 2476652 |
| temporary pacing in complete heart block due to lyme disease: a case report. | the authors present the case of a 44-year-old man who was admitted with complete heart block and signs of severe bradycardia. after steroid administration and temporary pacemaker treatment the complete heart block resolved. during this therapy transient st segment and t wave abnormalities occurred. the positive borrelia burgdorferi antibody titer arrived only after therapy had been completed. this is regarded as the first case of lyme carditis with complete heart block diagnosed in eastern europ ... | 1989 | 2476769 |
| evidence for spirochetal origin of sudeck's atrophy (algodystrophy, reflex sympathetic dystrophy). | four female patients with sudeck's atrophy (sa) were evaluated at our department. sera of all patients were investigated for antibodies against borrelia burgdorferi. in all patients elevated igg antibody titers and in one patient also elevated igm titer were found. in one patient structures identical with b. burgdorferi could be detected on histological sections from the skin of the affected limb. our data and those of other authors suggest that a spirochetal infection can be regarded as an impo ... | 1989 | 2476974 |
| bilateral keratitis in lyme disease. | lyme disease, caused by the spirochete borrelia burgdorferi, has ophthalmic manifestations. the authors describe two cases of lyme keratitis characterized by multiple focal, nebular opacities at varying levels of the stroma which may progress to edema, neovascularization, and scarring. close observation, in addition to systemic antibiotic therapy, may be sufficient if the visual axis is not involved, and the patient is asymptomatic. | 1989 | 2477779 |
| molecular mimicry and lyme borreliosis: a shared antigenic determinant between borrelia burgdorferi and human tissue. | the pathogenesis of chronic manifestations in lyme borreliosis, a disease induced by borrelia burgdorferi, is at present unresolved. by testing monoclonal antibodies directed against various borrelia antigens, we found an antigenic determinant shared by the 41 kda flagella protein and human tissue, especially prominent on myelinated fibers of human peripheral nerve, on nerve cells and axons of the central nervous system, as well as on certain epithelial cells (including joint synovia) and on hea ... | 1989 | 2481425 |
| structural features of borrelia burgdorferi--the lyme disease spirochete: silver staining for nucleic acids. | borrelia burgdorferi--the lyme disease spirochete--was grown in modified kelly medium and characterized by transmission and by scanning electron microscopy. using silver staining procedures which preferentially bind to nuclear components of eukaryotic cells, signal could be detected by backscattered electron imaging throughout the length of the prokaryotic spirochete. interestingly, however, the highest levels of backscattered signal were observed in naturally elaborated membrane blebs that were ... | 1989 | 2482525 |
| [lymphocytic meningoradiculitis (bannwarth's syndrome). neurologic involvement of lyme disease]. | we describe a patient with lyme's disease who showed neurologic symptoms of meningoradiculitis (bannwarth's syndrome) and had no previous history of exposure to tick bite or chronic erythema migrans. he had longterm fever and bilateral facial paralysis. antibody titres for borrelia burgdorferi in serum and cerebrospinal fluid (csf) were increased. the csf changes showed an intrathecal production of immunoglobulins (presence of plasmatic cells and immunoblasts; igg-csf: igg-serum ratio much highe ... | 1989 | 2490177 |
| [prevalence of antibodies against borrelia burgdorferi among the population of seville]. | in order to determine the prevalence of antibodies against borrelia burgdorferi in the area of sevilla, we have studied 300 healthy subjects of different age and sex groups by means of iif. of the 300 studied sera, only 4% had antibodies at titers greater than or equal to 1:16, a fact that shows the low prevalence of antibodies against this microorganism in the area. such titers were mainly found among subjects over 40 years (p less than 0.001). | 1989 | 2490479 |
| [new advances in rheumatology]. | (1) molecular pharmacology which is a starting to reach the market place, what is expected to be the next big step in the biotechnology revolution: the creation of complex compounds that are custom-designed to meet human needs. the new technology known as protein engineering promises to take us one step further by modifying natural proteins or by creating new ones especially by using somatic gene transfer and germ gene transfer and its influence on progeny. by doing this we hope to control some ... | 1989 | 2491405 |
| autoimmunity in lyme disease: molecular cloning of antigens recognized by antibodies in the cerebrospinal fluid. | in inflammatory disease of the central nervous system (cns), oligoclonal bands of immunoglobulin with restricted heterogeneity can often be observed in cerebrospinal fluid (csf) samples. these antibodies can be directed against the disease inducing pathogen or might be autoreactive and involved in the process of brain inflammation and demyelination. we used a molecular biology approach to characterize these antibody responses in patients with lyme disease. this disorder is caused by infections w ... | 1989 | 2491615 |
| another swedish family with complete properdin deficiency: association with fulminant meningococcal disease in one male family member. | inherited deficiency of the complement component properdin is described in a swedish family without any previous history of meningococcal infections. the properdin-deficient index patient died from a fulminant infection caused by neisseria meningitidis serogroup y. family investigation revealed properdin deficiency in the patient's half-brother and in the maternal grandfather. the half-brother had a history of pneumococcal pneumonia and meningitis probably caused by borrelia burgdorferi. opsonic ... | 1989 | 2502833 |
| comparison of culture, indirect immunofluorescence and dark-field microscopy for detection of spirochetes from ixodes ricinus ticks. | 1989 | 2504604 | |
| infected ticks feeding on persons in areas endemic for lyme disease and rocky mountain spotted fever. | 1989 | 2507649 | |
| prevalence of antibody indicating lyme disease in farmers in wigtownshire. | 1989 | 2510849 | |
| clinical and microbiologic findings in six patients with erythema migrans of lyme disease. | the clinical course of six patients with erythema migrans of lyme disease was viewed in the context of antibiotic susceptibility studies of their own borrelia burgdorferi isolates. an initial poor response by two patients to antibiotic therapy suggested the possibility of b. burgdorferi resistance to these agents. minimum bactericidal concentration determinations of eight antimicrobial agents against these isolates did not support this suggestion. | 1989 | 2511231 |
| comparison of western blot and enzyme-linked immunosorbent assay for diagnosis of lyme borreliosis. | the usefulness of western blot in the serological diagnosis of lyme borreliosis was evaluated compared with an elisa using a whole cell sonicate antigen. fifty-three of 68 (78%) patients with neuroborreliosis had positive igm and/or igg immunoblots and 40 of 68 (59%) had positive igm and/or igg elisa titers in serum. eight of 44 (18%) controls with meningitis/encephalitis of non-borrelia etiology had positive igm and/or igg immunoblots and 4 of 44 (9%) had positive igm and/or igg elisa titers in ... | 1989 | 2512131 |
| prevalence of antibody indicating lyme disease in farmers in wigtownshire. | 1989 | 2513072 | |
| prevalence of antibodies to borrelia burgdorferi in forestry workers and blood donors from the same region in switzerland. | sera from 259 forestry workers and 100 blood donors in the canton of solothurn, switzerland, were tested for igg antibodies to borrelia burgdorferi in two eias using as antigen either sonic extract of whole organisms or purified flagella. applying a 95% specific cut-off value based on results in the sera of 100 blood donors, 86 (33%) and 91 (35%) of the forestry workers respectively showed an elevated specific igg level in the two eias. none of the 259 forestry workers had clinical signs of acti ... | 1989 | 2513202 |
| a serological survey of ehrlichia canis, ehrlichia equi, rickettsia rickettsii, and borrelia burgdorferi in dogs in oklahoma. | serum samples from 259 dogs were tested for antibodies to ehrlichia canis, ehrlichia equi, rickettsia rickettsii, and borrelia burgdorferi using the indirect fluorescent antibody test. the sera were obtained from submissions to the oklahoma animal disease diagnostic laboratory during a 14-month period from june 1986 through july 1987. the rate for positive antibody titers to e. canis was 53%, to e. equi was 33%, to r. rickettsii was 38%, and to b. burgdorferi was 18%. higher percentages of sera ... | 1989 | 2518693 |
| temporal arteritis associated with borrelia infection. a case report. | a 71-year-old man had sudden vision loss associated with headache. a temporal artery biopsy revealed a typical picture of giant cell arteritis. subsequent steroid therapy failed to restore sight. a later blood culture contained spirochetes compatible with borrelia species, and a silver stain of the temporal artery biopsy specimen demonstrated a similar spirochete. treatment with i.v. ceftriaxone sodium led to some limited return of sight. to our knowledge, this is the first case report of a spir ... | 1989 | 2522942 |
| [isolation of borrelia burgdorferi in the cerebrospinal fluid in a patient treated with penicillin]. | 1989 | 2524738 | |
| ocular disease in caribbean patients with serologic evidence of lyme borreliosis. | four patients from caribbean and central american countries with ocular disease and serologic evidence of lyme borreliosis are discussed. to our knowledge this is the first report of lyme disease from this geographic area. two patients exhibited ocular inflammatory disease, and two patients developed optic neuropathy. a brief discussion of lyme borreliosis, its serologic diagnosis, and its treatment is presented. | 1989 | 2526160 |
| reversible horner's syndrome and lyme disease. | neurologic manifestations of lyme disease are common, often debilitating, and potentially treatable. we document a case of borrelia infection of the nervous system manifesting as a reversible horner's syndrome. the search for lyme disease should be part of the evaluation of an isolated central or preganglionic horner's syndrome or any unexplained pupillary abnormality. | 1989 | 2531158 |
| lyme neuroborreliosis: central nervous system manifestations. | we evaluated 85 patients with serologic evidence of borrelia burgdorferi infection. manifestations included encephalopathy (41), neuropathy (27), meningitis (2), multiple sclerosis (ms) (6), and psychiatric disorders (3). we performed lumbar punctures in 53, brain mri in 33, and evoked potentials (eps) in 33. only patients with an ms-like illness had abnormal eps, elevated igg index, and oligoclonal bands in the cerebrospinal fluid. twelve of 18 patients with encephalopathy, meningitis, or focal ... | 1989 | 2542840 |
| comparative antimicrobial activity of the new macrolides against borrelia burgdorferi. | the in vitro and in vivo activity of the new macrolides azithromycin, clarithromycin and roxythromycin was compared with that of erythromycin against borrelia burgdorferi. in in vitro tests using ten clinical isolates all macrolides were highly active against borrelia burgdorferi (mic90 0.015-0.06 micrograms/ml). azithromycin was more potent than the other macrolides in experimental animal infection, eradicating the organism in all animals tested at a dosage of 8 mg/kg. | 1989 | 2550233 |
| treatment of lyme borreliosis. | the infectious process of lyme disease can appear as chronic dermatologic, rheumatologic, or neurologic. to rationally select a treatment regimen, the physician must have an appreciation of the clinical manifestations of the illness and of the systemic nature of the infection. the authors discuss the proper treatment protocols for each stage in the progression of lyme disease. | 1989 | 2555849 |
| restriction endonuclease analysis of four borrelia burgdorferi strains. | a restriction endonuclease analysis was performed on four strains of borrelia burgdorferi: one isolated from man (sf), one from ixodes dammini (b31) and two from i. ricinus (bits in italy and b45 in germany). digestion by taq i and hae iii gave the best resolution of the dna fragments. three different restriction patterns were obtained: bits and b45 showed only one band difference. these results correlate with the reactivity of the four strains with monoclonal antibodies. | 1989 | 2560664 |
| hearing impairment in patients with antibody production against borrelia burgdorferi antigen. | this study aimed to evaluate the extent to which hearing disorders may be a result of tick-borne borrelia burgdorferi infection. 98 patients with different patterns of hearing dysfunction were studied. the patients had a history of sudden hearing loss, disorders similar to menière's disease, or hearing loss in combination with acute facial palsy or with vertigo. serum antibodies against the b burgdorferi antigen were determined during the acute and convalescent periods. 17 patients (17%) showed ... | 1989 | 2563002 |
| seronegative neuroborreliosis. | 1989 | 2563818 | |
| lyme disease: prevalence and clinical importance of borrelia burgdorferi specific igg in forestry workers. | 41 forestry workers, who had a high occupational risk of tick-bites, were screened for antibodies to borrelia burgdorferi by elisa and western blotting techniques, and questioned about possible symptoms of lyme disease. antibodies were detected in 10 of the 40 men who had been bitten by ticks. definite symptoms of lyme disease, in the form of erythema migrans, were reported by only 2 workers and none had a history of neurological illness. | 1989 | 2563850 |