Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| antibodies to htlv-1 in saliva of seropositive individuals from japan. | secretory antibodies protect mucosal surfaces against transmission of many viruses. human t-lymphotropic virus, type i (htlv-i) is transmitted via blood products and via sexual contact across mucosal surfaces. we investigated the presence of htlv-i-specific antibodies in whole saliva samples from 10 seronegative and 28 seropositive volunteers from a hospital in southern japan. antibodies directed to htlv-i antigens were found in the salivas from 22 of 28 (79%) of the seropositive subjects. none ... | 1987 | 3509678 |
| seroprevalence of hiv infection in high risk groups in manipur. | as part of a government surveillance program aimed at tracking the incidence of human immunodeficiency virus (hiv), 635 individuals from the indian state of manipur who were considered at high risk of infection were screened in 1986-87 for antibodies to hiv. screening was accomplished through use of commercial enzyme-linked immunosorbent assay (elisa) kits supplied by the indian council of medical research and the ministry of health. the manipur sample included 248 patients from sexually trans ... | 1987 | 3509856 |
| evaluation of heterosexual partners, children, and household contacts of adults with aids. | forty-five adults with the acquired immunodeficiency syndrome (aids) and their 45 spouses, 109 children, and 29 household contacts were studied for evidence of heterosexual, perinatal, and household spread of human t-cell lymphotropic virus type iii (htlv-iii) infection. of the 45 spouses enrolled, 26 (58%) had antibody to htlv-iii, including 12 (71%) of 17 male spouses and 14 (50%) of 28 female spouses. of the 12 seropositive male spouses, nine were seropositive at enrollment and three had sero ... | 1987 | 3467077 |
| aids in sicily: prevalence of antibodies to human immunodeficiency virus (hiv) in low and high risk groups. | a seroepidemiological survey, carried out to evaluate the prevalence of antibodies to hiv in patients with arc and in healthy individuals at risk for aids, showed the infection to be widespread in the groups at risk, namely in drug abusers and hemophiliacs. however, remarkable difference existed between the prevalence of antibodies to hiv in drug abusers of the city of palermo and those of other sicilian provinces. spread of the virus among sicilian thalassemics, however, was very low and quite ... | 1987 | 3498647 |
| unresponsiveness to skin testing with bacterial antigens in patients with haemophilia a not apparently infected with human immunodeficiency virus (hiv). | unresponsiveness to skin testing with ppd and tetanus toxoid was commonly seen in patients with haemophilia a but not infected with human immunodeficiency virus but was uncommon in controls. vaccination history indicated that the unresponsive patients had not been immunised in childhood. other tests of immune competence (skin tests with other antigens, lymphocyte stimulation with mitogens and antigens, and viral serology) showed that the haemophilia a patients had an adequate response to pathoge ... | 1987 | 3498742 |
| antibody-dependent cellular cytotoxicity-inducing antibodies against human immunodeficiency virus. presence at different clinical stages. | the presence of antibodies mediating antibody-dependent cellular cytotoxicity (adcc) against human immunodeficiency virus (hiv)-infected target cells was investigated with 170 sera from patients with varying severity of hiv infection. approximately 40% of sera from individuals representing all stages of infection were adcc-positive when tested against htlv-iiib infected 0937 clone 2 target cells. the positive sera had higher hiv antibody titers as measured by enzyme-linked immunosorbent assay co ... | 1987 | 3498755 |
| paraproteinemias in homosexual men with hiv infection. lack of association with abnormal clinical or immunologic findings. | during a prospective immunologic study of 130 homosexual men, the authors looked for the presence of paraprotein bands in serum by electrophoresis. antibody to the human immunodeficiency virus (hiv) was present in 65 of the 130 men, the lymphadenopathy syndrome (las) in 26, and the acquired immune deficiency syndrome (aids) in 3. abnormal bands were detected in the serum of six men, as single paraproteins in four and as oligoclonal bands in two. all six were seropositive for anti-hiv; one has la ... | 1987 | 3498358 |
| clinical, immunologic, and serologic findings in men at risk for acquired immunodeficiency syndrome. the san francisco men's health study. | forty-nine percent of homosexual/bisexual men were positive for antibody to the human immunodeficiency virus (hiv) in a population-based probability sample of 1034 single men recruited from san francisco. all heterosexual men were negative. among seropositive men, marked lymphadenopathy was present in 29%, and 16% had at least two other symptoms or signs suggestive of hiv infection. however, lymphadenopathy alone failed to indicate severity of immune impairment. the occurrence of two or more cli ... | 1987 | 3491910 |
| effect of t4 count and cofactors on the incidence of aids in homosexual men infected with human immunodeficiency virus. | we prospectively evaluated potential markers and cofactors for the acquired immunodeficiency syndrome (aids) in 86 homosexual men who were seropositive for human immunodeficiency virus antibodies. during three years of follow-up, 19 men developed aids. risk of aids was clearly predicted by the total number of circulating okt4-positive lymphocytes (t4 count) at enrollment, while the corresponding t8 count was unrelated to subsequent aids development. subjects in manhattan had a higher risk of kap ... | 1987 | 3491911 |
| human immunodeficiency virus: the eighth gene. | human t-lymphotropic virus type iii (htlv-iii/lav) has been shown to contain at least four extra genes in addition to the three essential genes (gag, pol, env) for replication of most retroviruses. these genes are expressed by complex splicing mechanisms and utilization of overlapping reading frames. we now demonstrate that there is an eighth gene which encodes a protein which is immunogenic and recognized by sera of some htlv-iii seropositive people. the gene is highly conserved among all known ... | 1987 | 3476127 |
| monoclonal anti-idiotypic antibody mimics the cd4 receptor and binds human immunodeficiency virus. | a monoclonal anti-idiotypic (anti-id) antibody, hf1.7, was generated against anti-leu-3a, a mouse monoclonal antibody (mab) specific for the cd4 molecule on human helper/inducer t lymphocytes. the anti-id nature of hf1.7 was demonstrated by the following properties. (i) it reacted in a solid-phase immunoassay with anti-leu-3a and not with a panel of irrelevant mouse mabs. (ii) it partially inhibited the binding of anti-leu-3a to cd4+ t cells. (iii) it detected a common idiotype present on variou ... | 1987 | 3495801 |
| pathogenesis of hiv and its implications for serodiagnosis and monitoring of antiviral therapy. | human immunodeficiency virus (hiv) is lymphotropic and neurotropic. in vivo clinical and immunological abnormalities develop in a large proportion of long-term hiv antibody seropositive persons. different stages of hiv infection are marked by expression of hiv genes, production of hiv antibodies, formation of antigen/antibody complexes and clearance of such complexes. transient hiv antigenemia appearing generally 6-8 wk prior to hiv antibody (hiv-ab) seroconversion and lasting 3-4 mth is general ... | 1987 | 3478346 |
| neoplastic complications of htlv-iii infection. lymphomas and solid tumors. | neoplastic disease arose in 29 of 200 patients infected with human t lymphotropic virus type iii (htlv-iii) seen at a suburban hospital. seventeen patients had kaposi's sarcoma, one of whom also had colon carcinoma. nine patients had lymphoproliferative disorders (seven lymphomas, one t suppressor cell chronic lymphocytic leukemia, and one multiple myeloma), including three with concomitant kaposi's sarcoma and one with colon cancer. one other patient had colon cancer, one had a seminoma, and on ... | 1987 | 3493690 |
| expression of the t4 molecule (aids virus receptor) by human brain-derived cells. | three human cell lines of astrocytic origin were evaluated for expression of a human t-lymphocyte surface glycoprotein, t4, which also serves as a cellular receptor for the human immunodeficiency virus (aids virus, hiv). t4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal okt-4 antibody and flow cytometry. gene transcripts encoding the t4 molecule were detected by a ribonuclease protection assay in surface t4-positive and -negative cells. our results suggest tha ... | 1987 | 3493919 |
| serologic and immunologic studies in patients with aids in north america and africa. the potential role of infectious agents as cofactors in human immunodeficiency virus infection. | serologic and immunologic studies were performed in 38 african and 60 us patients with acquired immunodeficiency syndrome (aids), 100 african and 100 us heterosexual men and women, and 100 us homosexual men to examine the potential role of infectious agents in human immunodeficiency virus (hiv) infection. there were no significant differences in the prevalence of antibodies to cytomegalovirus, epstein-barr virus, hepatitis a and b viruses, herpes simplex virus, syphilis, and toxoplasmosis among ... | 1987 | 3494857 |
| antibodies to human immunodeficiency virus in cervical secretions from women at risk for aids. | 1987 | 3474299 | |
| human immunodeficiency virus infection in women in the san francisco bay area. | 1987 | 3474426 | |
| autoradiographic localization of t4 antigen, the hiv receptor, in human brain. | using a novel autoradiographic technique and a monoclonal antibody to t4, the entry protein for the aids virus hiv, we have determined the distribution of t4 in selected areas of the human brain. t4 was found throughout the human brain in a pattern similar to that seen in squirrel monkey and rat, thus demonstrating a conservation of both the antigen and the antigen distribution. t4 was especially abundant in emotion-mediating areas, such as the hippocampus, which are typically enriched with neur ... | 1987 | 3496314 |
| effect of mitogens on the cell cycle progression and the quantification of t-lymphocyte surface markers in acquired immune deficiency syndrome. | the cell cycle progression and viability of stimulated and intact lymphocytes from 20 subjects with acquired immune deficiency syndrome (aids) was determined by flow cytometry. as compared to controls, 62% less aids lymphocytes, cultured for 72 hr in the presence of lectins (con-a, pha, pwm), had entered the proliferative phases of the cell cycle, while the respective value for periodic-acid (h5io6)-stimulated cells was 34%. the helper-suppressor ratios and natural kill cell percentages of the u ... | 1987 | 3496412 |
| hiv-specific cytotoxic t lymphocytes in seropositive individuals. | virus-specific cytotoxic t lymphocytes (ctl) which kill virus-infected cells are thought to be a major host defence against viral infections. here we report the existence of human immunodeficiency virus (hiv)-specific ctl in persons infected with this virus, the aetiological agent of aids (acquired immunodeficiency syndrome). recombinant hiv-vaccinia viruses were used to express hiv antigens in b-cell lines established from subjects seropositive for hiv and seronegative controls. circulating lym ... | 1987 | 3496541 |
| aids virus-specific cytotoxic t lymphocytes in lung disorders. | human immunodeficiency virus (hiv) is implicated in the development of aids (acquired immune deficiency syndrome). hiv infection leads to the generation of hiv-specific thymus-derived (t) lymphocytes in humans and apes. we describe an experimental system permitting the quantitative and systematic analysis of hiv-specific cytotoxic t lymphocytes (ctl). functional, hiv-specific ctl are obtained by broncho-alveolar lavage (bal) from the lungs of seropositive patients with lymphocytic alveolitis. th ... | 1987 | 3496542 |
| nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus: implications for immunologic classification of the disease. | blood specimens from 165 intravenous drug users who were seropositive for the human immunodeficiency virus (hiv), from 158 seropositive homosexual men with lymphadenopathy, and from 77 patients with acquired immunodeficiency syndrome (aids) were assessed immunologically. immunologic parameters were analyzed by the guttman scalogram technique to determine if immunologic abnormalities occurred in a nonrandom pattern. the following four patterns emerged: (i) seropositivity for hiv with no immunolog ... | 1987 | 3496603 |
| 3'-orf and sor genes of human immunodeficiency virus: in vitro transcription-translation and immunoreactive domains. | an in vitro transcription and translation procedure was designed to translate multiple open reading frames from cloned dnas. for human immunodeficiency virus (hiv) cloned dna carrying three open reading frames (sor, tat, and 3'-orf), the approach yielded three authentic polypeptides. clearly, the internal initiation codons can be used for reinitiation of translation of the downstream open reading frames. however, the downstream open reading frames were translated with relatively lower translatio ... | 1987 | 3496604 |
| detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus. | 1987 | 3496970 | |
| sequential changes in antibody levels to the env and gag antigens in human immunodeficiency virus infected subjects. | sera from 51 htlv-iii (human immunodeficiency virus, hiv)-antibody positive subjects consisting of 21 asymptomatic individuals and 15 arc and 15 aids patients were analyzed for their serological profiles toward the viral antigens. one of the asymptomatic subjects only showed a p24 reactivity in the immunoblot, but antibodies to the env antigens were clearly identified by immunoprecipitation of viral antigens (rip) followed by sds-polyacrylamide gel electrophoresis. rip patterns of different subj ... | 1987 | 3497054 |
| the world health organization's global strategy for the prevention and control of aids. | the magnitude of the human immunodeficiency virus (hiv) pandemic and its broad impact have been seriously underestimated and underappreciated. the special programme on aids (acquired immunodeficiency syndrome) of the world health organization (who) was created on february 1, 1987, as the architect and keystone of the global aids plan. the special programme on aids has designed the global strategy, has raised sufficient funds to begin implementing the strategy and, for this effort, has marshalled ... | 1987 | 3433760 |
| in situ hybridization of human immunodeficiency virus (htlv-iii) in cryostat sections of lymph nodes of lymphadenopathy syndrome patients. | the presence of human immunodeficiency virus (hiv, or htlv-iii) genome sequence was investigated by means of in situ hybridization in cryostat sections of lymph nodes from lymphadenopathy syndrome (las) patients. the technique employed involved the modification of the dna probe by chemical insertion of an antigenic sulfone group in cytosine moieties and the visualization of dna by a double-antibody immunohistochemical reaction. the hybrid formation was revealed in five out of ten cases: in all p ... | 1987 | 3497224 |
| 3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-hiv (htlv-iii/lav) agents. | a series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (hiv). the 2',3'-unsaturated analogues of 2',3'-dideoxycytidine (ddecyd) and 2',3'-dideoxythymidine (ddethd), 3'-azido-2',3'-dideoxythymidine (azddthd), 3'-fluoro-2',3'-dideoxythymidine, 2',3'-dideoxycytidine (ddcyd), and 2',3'-dideoxyadenosine (ddado) emerged as the most potent inhibit ... | 1987 | 3497272 |
| sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. | the characterization of hiv-1 (htlv-iii/lav), the human retrovirus associated with aids (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect cd4-bearing t lymphocytes. simian t-lymphotropic virus type iii (simian immodeficiency virus) from macaques (stlv-iiimac) induces symptoms similar to those of aids in infected macaques, but isolates from african green monkeys (stlv-iiiagm) and mangabeys (stlv-iimm) appear t ... | 1987 | 3497350 |
| the sor gene of hiv-1 is required for efficient virus transmission in vitro. | the genome of the human immunodeficiency virus hiv-1 contains at least eight genes, of which three (sor, r, and 3' orf) have no known function. in this study, the role of the sor gene was examined by constructing a series of proviral genomes of hiv-1 that either lacked the coding sequences for sor or contained point mutations in sor. analysis of four such mutants revealed that although each clone could generate morphologically normal virus particles upon transfection, the mutant viruses were lim ... | 1987 | 3497453 |
| cytotoxic factors secreted by cells infected by human immunodeficiency virus type i. | conditioned media from human immunodeficiency virus type i (hiv-1) infected cells were tested for cytotoxic cell-derived factors. the assay used a murine fibroblast cell line which is sensitive to the effects of tumor necrosis factors, but nonpermissive for hiv-1 replication. cytotoxic activity was detected in cultures of peripheral blood mononuclear cells infected with hiv-1. however, no differences in activity were found in conditioned media from infected lymphoid or monocytoid cell lines comp ... | 1987 | 3497655 |
| demonstration of antibodies to the surface (anti-p41) and core proteins (anti-p24) of the human immunodeficiency virus (hiv) in individuals positive for anti-hiv. | diagnosis of infection with the human immunodeficiency virus (hiv) relies on the demonstration of antibody to this virus. occasionally, the combined analysis of sera using elisa and western blot reveals false-positive results. we have compared a newly developed test to detect antibodies to the core (anti-p24) and surface (anti-p41) proteins of hiv with the established tests described above. anti-p24 and anti-p41 were negative in three individuals positive for anti-hiv by elisa and immunoblot; th ... | 1987 | 3498088 |
| a second discriminator for biological false positive results in enzyme-linked immunosorbent assays for antibodies to human immunodeficiency virus (htlv-iii/lav). | two commercially available enzyme-linked immunosorbent assays (elisa) were compared in screening a large population of volunteer blood donors. one elisa utilized the human t-lymphotropic virus, type iii (htlv-iii) grown on national institutes of health t-lymphocyte cell line, h-9, as antigen source; the second used lymphadenopathy associated virus (lav) grown on pasteur institutes' t-lymphocyte cell line, cem-f. biological false positives (bfp) occurred at a rate of approximately 0.5 percent usi ... | 1987 | 3492793 |
| a human t-cell line resistant to cytopathic effects of the human immunodeficiency virus (hiv). | infection of human helper t lymphocytes with the human immunodeficiency virus (hiv) results in a rapid induction of cytopathic effects and cell lysis. we isolated a variant of the human t-lymphoblastoid cell line, cem, that is fully susceptible to hiv infection but resistant to virally induced cytopathic effects. exposure of the cells, designated cr-10, to hiv resulted in the expression of viral antigens in 100% of cells within 6-9 days. virus-infected cells remained fully viable and could be cu ... | 1987 | 3492810 |
| characterization of immunologic function in homosexual men with persistent, generalized lymphadenopathy and acquired immune deficiency syndrome. | a syndrome of persistent, generalized lymphadenopathy (pgl), related to the acquired immune deficiency syndrome (aids), has been described in homosexual men. to further characterize and correlate the immunologic status of patients with pgl with those in aids, we studied spontaneous and pokeweed mitogen (pwm)-induced igg synthesis by b-cells, t-cell subsets in peripheral blood (pb), natural cytotoxicity (nc), and interleukins (il)-1 and il-2 production in 39 homosexual patients (21 pgl; 13 aids; ... | 1987 | 3492262 |
| igg response to human immunodeficiency virus in experimentally infected chimpanzees mimics the igg response in humans. | 1987 | 3492573 | |
| relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing aids. | we investigated the relation of oral hairy leukoplakia (hl) to human immunodeficiency virus (hiv) infection and to the presence or development of aids. all 155 patients with hl seen in our clinic were immunosuppressed homosexual men. of 101 serum samples obtained from patients in this group who did not have aids, 100 showed antibodies to hiv. hiv was recovered from peripheral blood mononuclear cells of 22 of 28 patients tested. most serum samples examined by immunoblot assay reacted with the vir ... | 1987 | 3492574 |
| direct identification of class ii histocompatibility dr proteins in preparations of human t-cell lymphotropic virus type iii. | class ii histocompatibility dr antigen alpha and beta chains were isolated from preparations of human t-cell lymphotropic virus type iii grown in human h-9 cells. the proteins were purified by reversed-phase high-pressure liquid chromatography and identified by direct n-terminal amino acid sequence analysis of each chain. the purified dr alpha chain had an n-terminal amino acid sequence identical to the known sequence of human dr alpha chain through the first 37 residues. the n-terminal amino ac ... | 1987 | 3492611 |
| lymphocytic interstitial pneumonia in patients at risk for the acquired immune deficiency syndrome. | three patients with the acquired immune deficiency syndrome (aids) or aids-related complex and lymphocytic interstitial pneumonia are reported. all patients presented with progressive dyspnea, nonproductive cough, fever, anorexia, weight loss, and arterial hypoxemia. chest roentgenograms exhibited bilateral diffuse reticular-nodular densities. the diagnosis of lymphocytic interstitial pneumonia was made by fiberoptic bronchoscopy or open lung biopsy. two patients were treated with corticosteroid ... | 1987 | 3491742 |
| serological examinations of hiv-i in iran. | 544 human blood samples from 2 hospitals in teheran, iran, were tested for hiv-virus antibodies. 35 samples were positive in 2 different elisa tests; however, these samples were negative in the western blot test. further studies are underway. | 1987 | 3443754 |
| humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells. | the human immunodeficiency virus envelope gene was expressed in insect cells by using a baculovirus expression vector. the protein has an apparent molecular mass of 160 kda, appears on the surface of infected insect cells, and does not appear to be cleaved to glycoproteins gp120 and gp41. goats immunized with the 160-kda protein have high titers of antibody that neutralizes virus infection as measured by viral gene expression or cell cytolysis. in addition, immune sera can block fusion of human ... | 1987 | 3477816 |
| serologic characterization of human immunodeficiency virus infection by western blot and radioimmunoprecipitation assays. | the western blot and radioimmunoprecipitation assay (ripa) appear to be the most specific tests available for the detection of antibodies directed against human immunodeficiency virus (hiv). an investigation of 678 hiv-seropositive samples from 518 patients by the western blot assay indicates that the majority of patients who have been exposed to hiv exhibit antibodies directed against glycoprotein (gp) 41. the hiv-seropositive samples were categorized into four groups according to their western ... | 1987 | 3478005 |
| generalized lymphadenopathy with morphologic features of castleman's disease in an hiv-positive man. | in recent years the literature has described a highly lethal "multicentric" variant of classic castleman's disease (cd) with similar hyperplastic angio-follicular morphologic features. a 44-year-old man who was not known to be part of any established high-risk group for the acquired immune deficiency syndrome (aids) presented with clinical and laboratory features similar to "multicentric" cd. serologic testing revealed antibody to the human immunodeficiency virus (hiv) by western blot analysis. ... | 1987 | 3478119 |
| streptococcal protein g: a sensitive tool for detection of antibodies to human immunodeficiency virus proteins in western blot analysis. | protein g is a cell wall protein of group c and g streptococci which binds human igg antibodies of all four subclasses with high affinity. this property of the molecule was utilized to develop a sensitive western blot assay to detect antibodies against hiv proteins in patient sera. | 1987 | 3478192 |
| [positive hiv (human immunodeficiency virus) serology in the pregnant woman: current data on its management. apropos of a continuous series of 56 cases]. | 56 cases of pregnant women with a positive hiv serology were reported in 20 months at the maternity of the nice hospital center. in 10 cases, there were clinical signs of the disease (9 arc-syndrome, one case of aids). the predisposing factor was most of the time drug addiction, 53 cases (94.5%) and one case occurred after a blood transfusion. in the majority of the cases (52%) the pregnancy was pursued because of the late term or the patient's decision. a therapeutic abortion was performed in 1 ... | 1987 | 3478787 |
| patterns of antibodies to human immunodeficiency virus proteins in different subclasses of igg. | 1987 | 3479499 | |
| antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus. | human immunodeficiency virus (hiv) elicits the production of virus-specific antibodies in infected individuals. we investigated the ability of serum from hiv-infected individuals to mediate antibody-dependent cellular cytotoxicity in an in vitro 51cr release assay system. fresh peripheral blood mononuclear cells from healthy donors seronegative for hiv were used as cellular effectors against hiv-infected and uninfected h9 target cells in the presence of serum from hiv-infected or uninfected dono ... | 1987 | 3479500 |
| isolation of human immunodeficiency virus (hiv) from plasma during primary hiv infection. | human immunodeficiency virus (hiv) has been isolated from plasma in 6 of 7 patients showing clinical symptoms of a primary hiv infection. parallel cultures from peripheral blood mononuclear cells (pbmc) yielded virus in 5 patients. in one case, virus could only be isolated from the cerebrospinal fluid but not from peripheral blood. detectable viremia was transient and preceded the appearance of hiv specific antibodies. after cessation of acute symptoms, the frequency of hiv isolations was simila ... | 1987 | 3479517 |
| gallium scanning in lymphoid interstitial pneumonitis of children with aids. | lymphoid interstitial pneumonitis (lip) is a frequent pulmonary complication in the child with the acquired immune deficiency syndrome (aids) and human immunodeficiency virus (hiv) infection. we report the gallium scan findings in two children with aids and lip. gallium scintigraphy in both children demonstrated increased radionuclide concentration throughout the lungs, a pattern indistinguishable scintigraphically from that of pneumocystis carinii pneumonia (pcp). this should alert nuclear medi ... | 1987 | 3479536 |
| [acute lymphoblastic leukemia of the burkitt's type in a patient seropositive for the human immunodeficiency virus]. | 1987 | 3479667 | |
| infection of the retina by human immunodeficiency virus type i. | 1987 | 3479685 | |
| serological responses in chimpanzees inoculated with human immunodeficiency virus glycoprotein (gp120) subunit vaccine. | the major envelope glycoprotein of a human immunodeficiency virus (hiv) has been purified and was utilized as a prototype vaccine in chimpanzees. the 120,000-dalton glycoprotein (gp120) was purified from membranes of human t-lymphotropic virus (htlv)-iiib-infected cells and the final preparation contained low levels to no detectable htlv-iiib core antigen (p24) and low levels of endotoxin. chimpanzees inoculated with gp120 responded by developing antibodies that precipitated radiolabeled gp120 a ... | 1987 | 3479807 |
| simian models for aids. | the macaque immunodeficiency syndrome has many parallels to aids in humans. affected monkeys develop profound, prolonged t lymphocyte dysfunction and die of lymphomas or opportunistic infections. we recently isolated a virus that we call siv from four sick macaque monkeys. the morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of human aids. the pathogenicity of this newly isolated virus was tested in macaque monkeys. fiv ... | 1987 | 3480063 |
| detection and characterization of circulating immune complexes in hiv-related diseases. | using an ultracentrifugation technique human immunosuppressive virus (hiv) (gp15 and gp41), anti-hiv (anti-gp15 and anti-gp41) immune complexes were detected in the sera of 3 (1 acquired immune deficiency syndrome (aids), 1 aids related complex (arc), 1 lymphadenopathy syndrome (las] out of 6 patients studied. evidence for presence of hiv immune complexes was provided by: 1) demonstration of gp15 anti-gp15 and gp41 anti-gp41 immune complexes at neutral ph (ph 7.2); and 2) presence of free hiv an ... | 1987 | 3480082 |
| fcr-mediated clearance in thrombopenic and non-thrombopenic patients with hemophilia a and possible relation of thrombopenia to hiv seropositivity. | as morbidity of thrombopenia in hemophilia a patients is increasing, the pathogenetic influence of the reticuloendothelial system (res) was measured using autologous anti-rh0(d)-coated erythrocytes (ea) in 17 patients with or without thrombopenia. mean survival of ea in patients was reduced to 53% of healthy controls (53.2 +/- 46.1 min vs 100.5 +/- 12.2 min; patients vs controls, mean +/- s.d.). survival of ea was not significantly different either in thrombopenic vs non-thrombopenic nor anti-hi ... | 1987 | 3480239 |
| brain pathology induced by infection with the human immunodeficiency virus (hiv). a histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. | neuropathological examination of brain tissue of 100 patients with infection by the human immunodeficiency virus (hiv), including 98 with clinically manifest acquired immune deficiency syndrome (aids), revealed distinct multifocal-disseminated and diffuse brain tissue lesions, which can be regarded as hiv-induced brain lesions: multifocal giant cell encephalitis (mgce; 4) and progressive diffuse leukoencephalopathy (pdl; 25). these lesions were found in 38 brains, and in 17 in absence of infecti ... | 1987 | 3434225 |
| detection of antibodies to human immunodeficiency virus (hiv) in eluates from whole blood impregnated filter paper discs. | a method for elution of hiv antibodies from whole blood or serum impregnated filter paper discs was developed. the results from testing of 73 eluates in an enzyme linked immunosorbent assay and the immunoblotting test agreed with the results obtained by ordinary serum testing. significant loss of antibody activity was not observed, neither in the eluates after storage for 1 mth at -20 degrees c nor in the filter paper discs after storage for 3 mths at +4 degrees c. this technique may be useful i ... | 1987 | 3480292 |
| [survey of antiviral antibodies against human immunodeficiency virus in a population of 11,174 blood donors]. | 1987 | 3480407 | |
| prevention and control of acquired immunodeficiency syndrome. an interim report. | the recommendations of this interim report on the prevention and control of aids, which was approved by the house of delegates of the american medical association (ama) at its 1987 annual meeting, "have as their foundation an overriding concern for a judicious balance between the well-being of human immunodeficiency virus (hiv)-positive patients and the protection of the public health." the recommendations include (1) development of a national policy; (2) establishment of a national commission ... | 1987 | 3477655 |
| natural history of endemic type d retrovirus infection and acquired immune deficiency syndrome in group-housed rhesus monkeys. | a 2.5-year epidemiologic study of a breeding group of rhesus monkeys (macaca mulatta), which is a focus of endemic simian acquired immunodeficiency syndrome (saids), demonstrated a strong association between the occurrence of saids and infection with a type d retrovirus, saids retrovirus serotype 1 (srv-1). of 23 healthy "tracer" juvenile rhesus monkeys, 19 (83%) died with saids within 9 months of introduction into the resident saids-endemic population. in contrast, 21 healthy "sentinel" juvenil ... | 1987 | 3477665 |
| [analysis of antibodies to human t-lymphotropic type iii virus (anti-htlv iii) in a population at high risk for aids in yugoslavia]. | 1987 | 3477674 | |
| antibody to the human immunodeficiency virus in women seeking abortion in new york city. | 1987 | 3477108 | |
| compulsory premarital screening for the human immunodeficiency virus. technical and public health considerations. | the effectiveness of a mandatory premarital screening program was examined as a means of curtailing the spread of the human immunodeficiency virus (hiv) infection in the united states. the epidemiology of the hiv, the technical characteristics of tests for antibodies to hiv, and the logistic, economic, and legal implications of such a program were considered. in one year, universal premarital screening in the united states currently would detect fewer than one tenth of 1% of hiv-infected individ ... | 1987 | 3476759 |
| human immunodeficiency virus antigenemia. | 1987 | 3476761 | |
| lack of reactivity of anti-human immunodeficiency virus (hiv) p17/18 antibodies against alpha 1 thymosin and of anti-alpha 1 thymosin monoclonal antibody against p17/18 protein. | the blood rate of alpha 1 thymosin is increased during hiv infection, despite the thymus involution. anti-alpha 1 thymosin antibodies inhibit hiv replication in vitro. a homology between alpha 1 thymosin and the hiv p17/18 core protein exists and would explain a cross-antigenicity. we have studied the interaction between anti p17/18 antibodies from hiv patients and alpha 1 thymosin and between an anti-alpha 1 thymosin monoclonal antibody and the p17/18 protein. we were unable to confirm any cros ... | 1987 | 3480876 |
| lack of transmission of human immunodeficiency virus from infected to uninfected chimpanzees. | four uninfected chimpanzees were each housed in separate cages with an hiv-infected chimpanzee for six to twenty-nine months. despite close daily contact, all uninoculated chimpanzees remained seronegative for hiv, and virus was never isolated from peripheral blood mononuclear cells of the uninfected chimpanzees. these data indicate that the probability of transmission from infected animals to humans is extremely low and also provide supportive evidence for lack of transmission of hiv by casual ... | 1987 | 3480958 |
| [serum expression of human immunodeficiency virus antigen(s) in persons at risk. evidence of disappearance of hiv-ag during the developmental course of patients with acquired immunodeficiency syndrome]. | 1987 | 3481007 | |
| [prevalence of antibodies against human immunodeficiency virus (hiv) and other infectious disease markers in blood donors from the city of puebla]. | 1987 | 3481100 | |
| [antibodies against human immunodeficiency virus (hiv) in a population of prostitutes in merida, yucatan, mexico]. | 1987 | 3481101 | |
| aids and antibodies to human immunodeficiency virus (hiv) in children and their families: clinical experience at yale-new haven hospital. | as of december 1986, we have identified 23 symptomatic children with human immunodeficiency virus (hiv) infection in new haven. twelve developed aids as manifested by lymphocytic interstitial pneumonitis, pneumocystis carinii pneumonia (pcp), and/or disseminated mycobacterial infections; seven of them have died. the remainder have milder clinical syndromes, which include failure to thrive, diffuse lymphadenopathy, and parotid swelling. when compared to adults with aids, children often have hyper ... | 1987 | 3481146 |
| simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody. | a simple, rapid, quantitative syncytium-forming microassay for the detection of human immunodeficiency virus (hiv-i) isolates is described. a virus-syncytial sensitive clone of cem cells (cem-ss) was identified and made adherent to flat bottom 96-well microtiter dishes. following the addition of virus, these cells develop easily quantifiable, adherent syncytia on a background of confluent, normal cem-ss monolayer in 4 to 6 days. one-hit kinetics for syncytia formation were obtained at various mu ... | 1987 | 3481271 |
| hiv antigen, hiv antibody and serum interferon in a patient with encephalopathy. | acute encephalopathy was associated with the presence of human immunodeficiency virus type i (hiv i) antigen and seroconversion to anti-hiv i in a 27-year-old homosexual man. examination of consecutive sera from the patient revealed circulating interferon (ifn) alpha which became detectable with the appearance of hiv i antigen but before development of anti-hiv i. serum ifn was present for only a limited time and was not demonstrable after neurological symptoms resolved. it may be speculated tha ... | 1987 | 3481357 |
| interaction of viral and cellular factors with the htlv-iii ltr target sequences in vitro. | the location of cis-acting regulatory sequences within the long terminal repeat (ltr) of the human t-cell lymphotropic virus type iii was determined by eukaryotic cell transfection and chloramphenicol acetyltransferase (cat) assay or in vitro cell-free transcription. a 160 base pair (bp) region of the ltr at position - 104 to 56 is required for trans-activation (cap site 1). a 24 bp enhancer element (ehe) capable of increasing the rate of transcription, irrespective of orientation, is located be ... | 1987 | 3481758 |
| [laboratory diagnosis of aids]. | the data on the morphogenesis, biology and genetics of human immunodeficiency virus, as well as on the epidemiology of aids, are presented. different assay systems developed in the ussr for the diagnosis of aids are described. the prospects for improving diagnostic techniques with the use of gene engineering are considered. | 1987 | 3481915 |
| anti hiv-2 serological screening in portuguese populations native from or having had close contact with africa. | to gather epidemiologic information on the spread of human immunodeficiency virus (hiv)-2 in portugal, sera were collected in 1985 from 156 healthy adults currently living in portugal but natives of guinea bissau, cape verde islands, saint tome/prince, angola, and mozambique and from 321 native portuguese men and women who had close contact with local african populations. as a control, sera were collected from 102 health portuguese with no previous contact with africa or african natives. the e ... | 1987 | 3482159 |
| oral manifestations of human immunodeficiency virus (hiv) infection. | 1987 | 3482220 | |
| [infection defense antigens against pathogenic viruses to human. infection defense antigens and genetic code--trend and progress of study on biomolecular analysis. o. human immunodeficiency virus]. | 1987 | 3482287 | |
| [antibodies against the human immunodeficiency virus in patients with systemic lupus erythematosus and other collagen-vascular diseases]. | 1987 | 3482295 | |
| [prevalence of antibodies against human immunodeficiency virus in prisoners and employees of penal institutions]. | 1987 | 3482330 | |
| to test or not to test: the value of routine testing for antibodies to the human immunodeficiency virus (hiv). | 1987 | 3482343 | |
| a serological survey for human immunodeficiency virus types 1 and 2 of individuals who visited health centers in tokyo. | the serum antibodies to human immunodeficiency virus types 1 (hiv-1) and 2 (hiv-2) were examined for among individuals who visited health centers in tokyo. of 8,198 sera screened, one was true-positive and 37 false-positive for hiv-1 antibodies. these 37 false-positives and 305 sera from the population groups at risk for hiv-2 (42 sojourners in africa, 251 homo- and bisexuals, and 19 prostitutes) were further examined for hiv-2 antibodies by indirect immunofluorescence and western blotting. no a ... | 1987 | 3483029 |
| [recommendations concerning the human immunodeficiency virus]. | 1987 | 3483225 | |
| presence of htlv-iii in tears and cells from the eyes of aids patients. | tears, conjunctival epithelium, and corneoscleral tissue from aids patients were used for the isolation of htlv-iii and also for identifying cell types which support its replication. htlv-iii was isolated from tears of aids patients (66.6%) by cultivation of cells and fluid from patients' eyes with fresh human mononuclear cells. the cells from the conjunctival scrapings of these patients (33.3%) revealed htlv-iii antigens by indirect immunofluorescence (if) using anti-p24 and p15 monoclonal anti ... | 1987 | 3483881 |
| human immunodeficiency virus type 2 infection associated with aids in west africa. | we recently reported the isolation of a new retrovirus, termed human immunodeficiency virus type 2 (hiv-2), from two west african patients with the acquired immunodeficiency syndrome (aids). this virus is related to but distinct from the well-characterized aids retrovirus, human immunodeficiency virus type 1 (hiv-1). we report here evidence of infection with hiv-2 in 30 patients, almost all from west africa. seventeen of them had a clinical syndrome indistinguishable from aids (7 of these 17 die ... | 1987 | 3472076 |
| what is safe sex? suggested standards linked to testing for human immunodeficiency virus. | because of the lethality of the hiv epidemic, rational and scientifically defined standards of sex that preclude the spread of sexually transmitted diseases are required. in the context of an hiv-antibody test that has been documented to be extremely sensitive and specific, standards for truly safe sex can be defined. hiv testing can be used as a powerful tool for defining a series of standards for sexual partners that eliminates, with reasonable certainty, the further spread of hiv. such standa ... | 1987 | 3472078 |
| oral hairy leukoplakia in three hemophiliacs with human immunodeficiency virus infection. | oral manifestations in aids, in aids-related complex, and in patients with antibodies to the aids-causing virus, human immunodeficiency virus (hiv), have been described previously. one of these manifestations, oral hairy leukoplakia, is apparently specifically associated with hiv infection and has until recently been reported in homosexual men only. this article demonstrates, among european patients, the occurrence of hairy leukoplakia in three patients belonging to another risk group for aids, ... | 1987 | 3472144 |
| cohort comparison study of children whose mothers have acquired immunodeficiency syndrome and children of well inner city mothers. | the virus or viruses (human immunodeficiency virus) associated with the acquired immunodeficiency syndrome may be transmitted in utero or perinatally from an infected mother to her baby. infected adults may remain asymptomatic for months to years, during which time a mother could transmit the virus. it is not known to what degree a mother may transmit the virus perinatally or whether postnatal transmission is possible. we studied a cohort of children whose mothers had been reported to have acqui ... | 1987 | 3472157 |
| human immunodeficiency virus can productively infect cultured human glial cells. | six isolates of the human immunodeficiency virus (hiv) showed differences in their ability to productively infect glioma-derived cell lines and early-passage human brain cell cultures. susceptibility to hiv infection correlated well with the expression of the astrocyte marker glial fibrillary acidic protein. the cd4 molecule was expressed on some, but not all, of the brain-derived cells; however, no correlation was observed between cd4 protein expression and susceptibility to virus infection. th ... | 1987 | 3472222 |
| expression of human immunodeficiency virus in cerebrospinal fluid of children with progressive encephalopathy. | the retrovirus that causes acquired immune deficiency syndrome (aids) is now designated the human immunodeficiency virus (hiv). the cerebrospinal fluid (csf) of 27 children with hiv infection was assayed for intra-blood-brain barrier (ibbb) synthesis of hiv-specific antibodies and for the presence of hiv antigen. in this cohort, 11 children had a progressive encephalopathy (pe), 9 had a static encephalopathy (se), and 7 had normal neurological findings (n). ibbb synthesis of hiv-specific antibod ... | 1987 | 3472486 |
| aids in africa: evidence for heterosexual transmission of the human immunodeficiency virus. | the sex and age distribution of acquired immunodeficiency syndrome (aids) in africa (i.e., a l:l male-female ration and a concentration in the 30-39-year age group) are similar to those recorded for other sexually transmitted diseases, both in developed and developing countries. in africa, aids shows a pattern of heterosexual transmission, and prevalence rates are highest among younger, sexually active women who have sexual relations with older men. 61% of african women with aids compared with ... | 1987 | 3473334 |
| assessment of lymph node size in hemophiliac children: observer agreement and association with serologic status to human immunodeficiency virus i. | lymphadenopathy is an important component of a wide variety of different illnesses including the acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related conditions. in this study two pairs of observers independently examined the lymph nodes of hemophiliacs younger than 18 years of age to determine the level of agreement of assessments of lymph node mass (the product of the number and mean diameter of lymph nodes). spearman correlation coefficients for the first and seco ... | 1987 | 3473425 |
| absence of cytotoxic antibody to human immunodeficiency virus-infected cells in humans and its induction in animals after infection or immunization with purified envelope glycoprotein gp120. | the presence of antibody-dependent complement-mediated cytotoxicity (acc) was assessed in humans and chimpanzees, which are capable of infection with human immunodeficiency virus isolate htlv-iiib, and examined in the goat after immunization with the major viral glycoprotein (gp120) of htlv-iiib. in infected humans no antibody mediating acc was observed regardless of the status of disease. even healthy individuals with high-titer, broadly reactive, neutralizing antibodies had no acc. in contrast ... | 1987 | 3473484 |
| prematurity, hypogammaglobulinemia, and neuropathology with human immunodeficiency virus (hiv) infection. | infection with the human immunodeficiency virus (hiv) is characteristically associated with hypergammaglobulinemia in both adult and pediatric cases. we report herein four infants who had an hiv infection in association with severe hypogammaglobulinemia and did not exhibit antibodies against hiv. hiv was isolated antemortem or postmortem in all four infants from either peripheral blood, cerebrospinal fluid, or body tissues. hiv infection could be presumed to be acquired transplacentally in two i ... | 1987 | 3473485 |
| intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees. | the presence of human immunodeficiency virus (hiv) antigens in cerebrospinal fluid (csf) was associated with progressive encephalopathy in adult and pediatric patients with acquired immunodeficiency syndrome (aids). hiv antigen was detected in csf from 6 of 7 aids patients with progressive encephalopathy. by contrast, hiv antigen, whether free or complexed, was detected in csf from only 1 of 18 hiv antibody seropositive patients without progressive encephalopathy and from 0 of 8 experimentally i ... | 1987 | 3473487 |
| [stomatological lesions seen in hiv virus infection. ii. histopathological and ultrastructural studies]. | buccal lesions observed in the clinical setting of human immunodeficiency virus (hiv) infection constitute a diverse group of pathological entities. several are related to the opportunistic infections observed in association with hiv infection. "hairy leukoplakia" is a recently described benign lesion that is presumably related to infection by epstein-barr virus (e.b.v.). kaposi's sarcoma is seen somewhat frequently in the oral cavity, especially involving the palate of hiv infected patients. we ... | 1987 | 3473605 |
| neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome. | neurologic disease was the harbinger of the acquired immunodeficiency syndrome (aids) in 26 (20%) of 132 patients and ultimately developed in 83 (63%). the most common neurologic disorder heralding aids was toxoplasmic encephalitis (17 cases) followed by cryptococcal meningitis (six), retinitis (three), progressive multifocal leukoencephalopathy (two), neuropathy (one), myopathy (one), and subacute "viral" encephalitis (one). in four patients, more than one neurologic disorder coexisted at prese ... | 1987 | 3473692 |
| oral findings in 23 patients with antibodies against hiv (human immunodeficiency virus). | 1987 | 3473717 | |
| heated clotting factors and seroconversion for human immunodeficiency virus in three hemophilic patients. | 1987 | 3473956 | |
| angioimmunoblastic lymphadenopathy, immunoblastic lymphoma, and false-positive seroconversion for human immunodeficiency virus. | 1987 | 3473957 | |
| interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus. | the human immunodeficiency virus (hiv) is a human retrovirus which is the etiologic agent of the acquired immunodeficiency syndrome. to study the cellular factors involved in the transcriptional regulation of this virus, we performed dnase i footprinting of the viral ltr using partially purified hela cell extracts. five regions of the viral ltr appear critical for dna binding of cellular proteins. these include the negative regulatory, enhancer, sp1, tata and untranslated regions. deletion mutag ... | 1987 | 3428273 |