Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| prodigiosin-like pigments from actinomadura (nocardia) pelletieri and actinomadura madurae. | thirteen red strains of actinomadura (nocardia) pelletieri and three of a. madurae were shown to produce prodigiosin-like pigments. both of the two major pigments which were observed on thin-layer chromatograms had r(f) values significantly greater than prodigiosin. the main pigment from a. madurae 953 was shown by mass and nuclear magnetic resonance spectroscopies to be nonylprodigiosin. the major pigment from a. pellitieri had a c(11)h(22) side chain in a ring form, but it was distinctly diffe ... | 1969 | 5803627 |
| a novel, cyclic, tripyrrole pigment from actinomadura (nocardia) madurae. | 1970 | 5436614 | |
| prodigiosin-like pigments from actinomadura (nocardia) pelletieri. | 1971 | 5132249 | |
| [production of antineoplastic antibiotic carminomycin by actinomadura carminata sp.nov]. | 1973 | 4776400 | |
| antibiotic ab-64, a new indicator-pigment antibiotic from actinomadura roseoviolacea var. rubescens. | 1973 | 4792063 | |
| properties of actinomadura madurae isolated from actinomycetoma with a note on taxonomy. | 1973 | 4807201 | |
| mycetoma caused by actinomadura (streptomyces) madurae. the first south african case and the results of chemotherapy. | 1974 | 4818623 | |
| [new species of the genus actinomadura]. | 1974 | 4444560 | |
| spore formation in actinomadura dassonvillei (brocq-rousseu) lechevalier and lechevalier. | 1974 | 4448985 | |
| [micromonospora rubra sveshnikova et al. equals actinomadura rubra comb. nov]. | 1974 | 4601020 | |
| [new genus of actinomycetes: excellospora gen. nov]. | morphological, cultural and physiological properties of two strains of soil thermophilic actinomycetes were studied. these strains were compared to the actinomycetes of related genera and were found to be close to micropolyspora and actinomadura. however, they differed from both genera by the structure of the sporiferous apparatus, from micropolyspora by the type of the cell wall, and from actinomadura by the fatty acid composition of lipids of the mycelium. a new genus of actinomycetes, excello ... | 1975 | 125848 |
| [isolation of new species of the genus actinomadura on selective media with rubomycin]. | in the screening programme of organisms producing new antibiotics on selective media with rubomycin (5, 10, 20 gamma/ml) 4 unusual actinomyceteus cultures forming short, straight, hook-like and monospiral spore chains on the aerial mycelium were isolated. the study of the composition of the cell walls showed that they contained meso-diaminopimelic acid and madurose, a differentiating sugar. on the basis of the morphological structure and composition of the cell walls the isolates were classified ... | 1975 | 773288 |
| mycetoma in iran. | the subject of mycetoma is reviewed and 7 cases are reported for the first time from southern iran. four were causes by actinomyces israelii and one each by nocardia asteroides, actinomadura madurae and allescheria boydii. | 1975 | 1092627 |
| a novel actinomycete from sugar-cane bagasse: saccharopolyspora hirsuta gen. et. sp. nov. | a new species of nocardioform actinomycete isolated from spontaneously heated sugar-cane bagasse is described as saccharopolyspora hirsuta gen. et sp. nov. it has affinities with species of both nocardia and actinomadura but can be distinguished from both genera by its morphology, sporulation, wall and lipid analyses, antibiotic resistance, degradation and carbon utilzation tests. | 1975 | 1097584 |
| [the application of chorioallantois membranes of chicken embryos for the virulence determination of nocardia asteroides (author's transl)]. | the pathogenicity of nocardia asteroides and other strains of different nocardia species against chicken embryos was investigated. the strains were inoculated on the chorioallantois membrane of embryonated eggs and the resulting lesions were judged. 55 nocardia asteroides strains and some strains of the species n. brasiliensis, n. leishmanii, n. caviae, n. (actinomadura) madurae, n. caprae, n. rubra, n. pellegrini, n. corallina and n. polychromogenes were studied. 47 strains of the species n. as ... | 1975 | 1101585 |
| [systematic position of streptomyces luteofluorescens]. | on the basis of the cell wall composition (the presence of meso-diaminopimelic acid and madurose sugar) and according to the morphological structure, streptomyces luteofluorescens (type culture 719, isp 5398) is transferred to actinomadura genus. the organism is considered to be a new species of the actinomadura genus -- actinomadura luteofluorescens (shinobu, 1962) preobrazhenskaya et lavrova, 1974, comb. nov. | 1975 | 1160657 |
| production of carminomycin by auxotrophic mutants of actinomadura carminata. | 1975 | 1189475 | |
| [ultrastructure of the mycelium and spores of actinomadura fastidiosa sp. nov]. | a new species of the actinomadura genus, a. fastidiosa sp. nov., is described. the ultrastructure of the vegetative mycelium and spores of this organism was studied. the vegetative cells have a multilayered cell wall, often consisting of five layers with different thickness and electron density. the spores are similar to the vegetative cells by their inner structure but have a thicker wall. | 1975 | 1207505 |
| [actinomadura cremea var. rifamycini, a producer of rifamycin o]. | 1975 | 1225170 | |
| [optimization of the nutrient medium makeup for the biosynthesis of carminomycin using mathematical methods of experimental design]. | the nutrient medium for biosynthesis of carminomycin by actinomadura carminata, strain 4281 was optimized with the methods of mathematical planning of the experiment. the starting variant of the medium, production of carminomycin on which was assumed equal to 100 per cent was enriched during the experiments carried out according to the patterns of the orthogonal latin squares. the production levels of carminomycin on the above medium was more than 3 times higher than those on the starting medium ... | 1975 | 1225180 |
| [isolation of new species of the genus actinomadura on selective media with streptomycin and bruneomycin]. | in the screening programme using selective media with streptomycin (25, 50 and 100 gamma/ml) and bruneomycin (0.5, 1 and 2 gamma/ml) 3 unusual actinomycetous cultures forming short, rarely long chains of straight, hook-like or spiral spores with 1 or rarely 2 turns were isolated. the study of the cell wall composition of the isolates showed that the walls contained meso-diaminopimelic acid and a sugar madurose. on the basis of the morphological structure and the cell wall composition the isolate ... | 1975 | 1225188 |
| [heterogeneity of the genus actinomadura lechevalier a. lechevalier]. | studies of the morphology of actinomadura spp. have shown that the genus comprises several morphological types of actinomycetes which differ by the presence and structure of the sporophores on the aerial and substrate mycelium. the actinomycetes differ also by the fatty acid composition of lipids in the mycelium, and can be subdivided into three groups: (1) fatty acids with a straight chain prevail; (2) fatty acids with branched chains of the iso- and anteiso structure predominate; and (3) fatty ... | 1975 | 1226138 |
| a study of 3891 cases of mycoses in the tropics. | 4103 cases suspected of mycoses were analysed as to sex, age and site of disease and 3891 were proved cases. this group formed 50% of total mycoses or 13-93% of all dermatoses recorded in the government general hospital, madras, during the period of study. there were 66-26% adult female, 27-6% adult male and 6-14% were below 13 years. dermatophytoses were found in 73-5%; the other common diseases were tinea versicolor (17-68%) and candidiasis (12-43%). multiple sites of involvement or more than ... | 1976 | 134458 |
| [new species of actinomadura coeruleoviolacea sp. nov. and its antagonistic properties]. | eight strains of actinomycetes isolated from soil samples were described as representatives of actinomadura coeruleoviolacea sp.nov. the species was characterized by straight and sometimes branching short chains of spores, smooth spores, blue aerial mycellium and violet soluble pigment. all the strains showed antibacterial activity when cultivated in liquid media. the pigment differed from all known pigments. it is probably a new natural compound. | 1976 | 999259 |
| [subsequent mutagenesis under the action of uv rays in a culture of actinomadura carminata, a producer of carminomycin]. | the succession of some markers on the chromosomes of actinomadura carminata was shown with the method of successive mutagenesis based on the preferable effect of the mutagen on dna in the site of replication. the spore germination was synchronized by selection of the spores of the definite size and maintenance at a temperature of 0 degrees. the periods of formation of the highest numbers of morphological and auxotrophic mutants were compared with the time of dna replication. | 1976 | 999262 |
| [effect of aeration conditions on the biosynthesis of carminomycin by an actinomadura carminata culture]. | the effect of the aeration rate on biosynthesis of carminomycin by actinomadura carminata and biochemical changes in the fermentation broth on the use of 3 complex media of different composition was studied. the carminomycin-producing organism can grow and produce the antibiotic within the ranges of the aeration changes from 0.98 to 18.56 mgo2/1-min. a decrease in the maximum rate of oxygen dissolution up to 0.98 mgo2/1-min resulted in some decrease in the activity level. intensive aeration, i.e ... | 1976 | 1020937 |
| relationship between the quality of the inoculum material and carminomycin biosynthesis by a culture of actinomadura carminata. | the effect of the inoculum mycelium quality on carminomycin biosynthesis by actinomadura carminata was studied. the time of the organism growth on the culture medium containing cornsteep liquor continued for 6 hours without losing by the inoculum of its seeding qualities during that period. the mycelium growth in the inoculum was more intensive under conditions of moderate aeration, i.e. 0.98-2.64 mg o2h1-min. anincrease in the aeration rate up to 18.56 mg o2/1-min resulted in the growth suppres ... | 1977 | 18979 |
| mycetoma in somalia - results of a survey done from 1959 to 1964. | the pasteur institute studied 103 mycetoma patients in somalia between 1959 and 1964. grains were seen in 94 of them and this, added to cultural features, allowed the diagnosis of 60 pathogens as follows: 44 madurella mycetomi, 1 leptosphaeria senegalensis, 7 pyrenochaeta romeroi (or madurella grisea), 3 allescheria boydii, 1 fusarium sp., 3 neotestudina (zopfia) rosatii, and 1 unidentified; 34 were actinomycetes: 24 streptomyces somaliensis, 4 actinomadura madurae, 3 a. pelletieri and 3 nocardi ... | 1977 | 23657 |
| mycetomas in madras. | in 90 of 150 cases clinically diagnosed as mycetoma in the department of pathology, madras medical college, from january 1964 to june 1975, histopathological study revealed granules. besides special staining procedures, cultural methods were undertaken in recent cases. the age and sex incidence, site of lesion and the species of fungi identified on the basis of histological morphology of the granules are analysed. the disease was predominatly seen in the age group 21-40. men were more frequently ... | 1977 | 558655 |
| a method for determining in-vitro drug susceptibilities of some nocardiae and actinomadurae: results with 17 antimicrobial agents. | a simple timesaving method for determining drug susceptibilities in vitro of isolates of nocardia and actinomadura is reported. an isolate is considered "susceptible" when the quantity of drug required for inhibition of growth is that concentration which might be obtained in serum by conventional therapy. sulfonamides remain the drugs of choice for treating disease due to nocardia species. although doxycycline and minocycline appear to be very effective against nocardia species, susceptibility t ... | 1977 | 327792 |
| distribution of menaquinones in actinomycetes and corynebacteria. | menaquinones were the only isoprenoid quinones found in 48 corynebacteria and actinomycete strains examined. dihydromenaquinones having nine isoprene units were the main components isolated from gordona, mycobacterium, corynebacterium bovis, corynebacterium glutamicum and a strain labelled nocardia farcinica, but dihydromenaquinones having eight isoprene units were characteristic of other corynebacterium species and representatives of the 'rhodochrous' complex. tetrahydromenaquinones having six ... | 1977 | 894261 |
| [foot mycetoma of double etiology]. | a patient coming from an area of dry tropical forest was studied. this patient had in his right foot two tumor-like growths localized, one in the anterior and superior part of the foot, the other near the malleoli. from the first tumor, light-colored grains were obtained, and actinomadura madurae was cultured. from the tumor near the malleoli only black grains were isolated from which a pyrenochaeta sp. was cultured. | 1977 | 905922 |
| [electron microscopic study of spore formation in actinomadura verrucosospora]. | the formation of spores was studied with a morphologic type of the actinomadura genus, acd. verrucosospora (nonomura a. ohara, 1971. spore formation begins with the division of a hypha by cross-partitions which, as a rule, appear as monolayered on cross-sections, thus differing from sporulation septae found in other actinomycetes. the structure and shape of septae change in the course of spore formation: first, they consist of one layer and have the same thickness as the cell wall; later, they c ... | 1977 | 909469 |
| [selection of active strains of actinomadura carminata, the producer of carminomycin]. | the method of selecting active strains among a definite group of analogue-resistant mutants was used on the basis of studying the dependence of the carminomycin-producing organism growth and the antibiotic synthesis level on some metabolites. as a result, gamma-ray induced mutants 4 times more active than the parent strains were obtained. | 1978 | 623444 |
| [the role of histopathology in the diagnosis of mycetomas. two cases of maduromycosis. actinomadura pelletieri and leptosphaeria tompkinsii (author's transl)]. | 1978 | 686856 | |
| red grain mycetoma of the scalp (actinomadura pelletieri). a case report from india. | a case of red grain mycetoma on the scalp is described. the disease, caused by actinomadura pelletieri, is extremely rare in this part of the world, and from india this is perhaps the first case with scalp involvement. the lesion showed satisfactory response to partial excision followed by chemotherapy with streptomycin. | 1978 | 692630 |
| mycetomas in goats. | naturally occurring mycetomas were found in 3 goats. two had mycetomas on their hind legs and the third on its left scapula. in 2 goats the causative agents were identified by culture, histopathology and serology as actinomadura madurae. in the remaining goat diagnosis was based only on histopathology and the causative agent was considered to be a. pelletierii. despite minor differences between goat and human strains of a. madurae, it would seem that goats could be useful experimental models. | 1978 | 705558 |
| [antibiotic activity of cultures of the species of the genus actinomadura]. | sixty five cultures of actinomadura were isolated from samples of different soils. the study of their antibiotic activity on liquid nutrient media showed that 49 of them were active against gram-postive bacteria. the antibiotics isolated fromsome cultures of am. carminata, am. rubra, am. coerulea and am. luteofluorescens had antitumor effect in experiments on animals. | 1978 | 727753 |
| the exocellular dd-carboxypeptidase-endopeptidase from streptomyces albus g. purification and chemical properties. | the exocellular dd-carboxypeptidase-endopeptidase of streptomyces albus g was purified to protein homogeneity and compared with the exocellular dd-carboxypeptidases-transpeptidases of streptomyces r61 and actinomadura r39. the s. albus g enzyme, as it is isolated, occurs in two forms. enzyme i (30% of the total amount) and enzyme ii (70% of the total amount) are identical in all respects, except that, by polyacrylamide-gel electrophoresis in the presence of sodium dodecyl sulphate, enzyme i has ... | 1978 | 743235 |
| preliminary investigation of the use of the enzyme linked immunosorbent assay (elisa) in the serodiagnosis of mycetoma. | antibody levels in a small group of sudanese patients with clinically diagnosed mycetoma, and control groups were measured by countercurrent immunoelectrophoresis (cie) and enzyme linked immunosorbent assay (elisa). antigens were prepared from the following organisms: streptomyces somaliensis, actinomadura madurae, a. pelletieri, nocardia brasiliensis and madurella mycetomi. positive reactions were obtained in clinical cases against the homologous antigens in both cie and elisa; all heterologous ... | 1978 | 360443 |
| fermentation, isolation, and biological activity of maduramycin: a new antibiotic from actinomadura rubra. | in a continuing search for new antibiotics, the species actinomadura rubra (sveshnikova et al.) j. meyer et m. sveshnikova 1974 (strain imet 13001) was found to produce a red pigment with indicator properties, designated maduramycin. the pigment (c28h22o10; m.w. 518 m/e-; m.p. 305--310 degrees c (dec.); uvmax 225.307 nm) possesses a strong antimicrobial activity against gram-positive bacteria, including strains which produce inactivating enzymes for some commercial antibiotics. maduramycin forms ... | 1978 | 362738 |
| the exocellular dd-carboxypeptidase-endopeptidase of streptomyces albus g. interaction with beta-lactam antibiotics. | kinetically, the three-step model proposed for the interaction between beta-lactam antibiotics and the exocellular dd-carboxypeptidases-transpeptidases of streptomyces r61 and actinomadura r39 [frère, ghuysen & iwatsubo (1975) eur. j. biochem. 57, 343--357; fuad, frère, ghuysen, duez & iwatsubo (1976) biochem. j. 155, 623--629] applies to the interaction between the much less penicillin-sensitive exocellular dd-carboxypeptidase-endopeptidase of streptomyces albus g and at least phenoxymethylpeni ... | 1978 | 105727 |
| [isolation of actinomadura from soils on selective media with kanamycin and rifampicin]. | 1978 | 146454 | |
| 2'-amino-2'-deoxyadenosine produced by a strain of actinomadura. | 1979 | 317287 | |
| mycetomas in north india. | of 60 clinically suspected cases of mycetoma, 20 were confirmed by cultural and histopathological methods. the feet were found to be affected in 70% of the cases. the age group most affected by the disease was 20-40 years. men were involved in 18 while females were affected in 2 cases only. actinomycetomas (70%) were found more often than eumycetomas (30%). nocardia species were identified in 35% of cases and madurella mycetomi in 25%. there were four cases (20%) where the etiological agents cou ... | 1979 | 575236 |
| [new elementary structures of actinomycete spores of the genera actinomadura and streptomyces]. | the structure of spore surfaces was studied by electron microscopy in five species of actinomycetes, and two new types of elementary surface structures were discovered. the surface of spores in streptomyces regensis consists of long flexible, closely interwoven, band-like structures 25 a wide. ring-like structures 140--150 a in diameter can be observed on spores of actinomadura verrucosospora; their clusters resemble grapes and the spore silhouette looks like a cone. rod-like structures of spore ... | 1979 | 423813 |
| new species of the genus actinomadura. | 1979 | 442701 | |
| [agents of mycetomas: a bacteriological and parasitological study (author's transl)]. | microscopic agents responsible of mycetomas are reviewed. they may be bacteria belonging to the actinomycetalae order (nocardia, actinomadura, streptomyces) or very various fungi belonging to the classes of adelomycetes or ascomycetes (madurella, leptosphaeria, neotestudina, etc.). though the procedures for collecting and transporting samples are the same, direct microscopic examination gives possibility to choose among the selective culture media the most appropriate ones to isolate either fung ... | 1979 | 459790 |
| numerical taxonomy of actinomadura and related actinomycetes. | one hundred and fifty-six actinomadura strains, marker strains of related taxa, and related isolates from bagasse and fodder were the subject of numerical phenetic analyses using 90 unit characters. the data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using both single and average linkage algorithms. cluster composition was not markedly affected either by the coefficient or clustering algorithms used or by test error, esti ... | 1979 | 479835 |
| in vitro activity of cefoxitin against nocardia spp. and actinomadura spp. | 1979 | 500519 | |
| [mycetomas originated from south-east bulgaria (author's transl)]. | according to investigations by the author, bulgaria occupies a major position by the number of mycomas in european countries with temperate climate and small area. from 18 cases of mycomas, 10 cases, whom 7 were maduromycetomas or eumycetomas, originated from south-east bulgaria, near black sea and asia minor, with warm and dry climate. this confirms that the climate has a definite influence on the disease. 6 maduromycetomas with black granules were caused by madurella mycetomi and the only whit ... | 1980 | 7194618 |
| bbm-928, a new antitumor antibiotic complex. ii. taxonomic studies on the producing organism. | an actinomycete strain no. g455-101 isolated from a soil sample collected in luzon island, philippines produced a new antitumor antibiotic complex bbm-928. the organism was determined to be a new species of the genus actinomadura and designated actinomadura luzonensis nov. sp. the type strain, no. g455-101, has been deposited under the number atcc 31491. | 1980 | 7451358 |
| survey of human pathogenic actinomycetes and fungi in soil from rome and other italian areas. | as part of a study sponsored by the ministry of health of italy, a research program on pathogenic actinomycetes, keratinophilic and pathogenic fungi in soil was carried out. two hundred soil samples, collected from different areas of the city of rome, calabria, emilia romagna, latium, apulia, sardinia, sicily, tuscany and umbria, were examined by several techniques to detect the widest possible variety of pathogenic actinomycetes and fungi. seven isolates of nocardia asteroides, four of actinoma ... | 1981 | 7012635 |
| studies on the primary structures of the exocellular d-alanyl-d-alanine peptidases of streptomyces strain r61 and actinomadura strain r39. | the mr 37 000 d-alanyl-d-alanine peptidase excreted by streptomyces r61 and the mr 53 000 d-alanyl-d-alanine peptidase excreted by actinomadura r39 are both characterized by a very uneven distribution of the basic (arg + lys) amino acid residues. trypsin degradation of the heat-denatured enzymes generates (1) thirteen soluble peptides which contain from 2 to 28 residues in the case of the r61 enzyme and nineteen soluble peptides which contain 2 to 39 residues in the case of the r39 enzyme; and ( ... | 1981 | 7034781 |
| baumycin analogs isolated from actinomadura sp. | 1981 | 7053087 | |
| synthetic peptide inhibitors of transpeptidation by the exocellular dd-carboxypeptidase-transpeptidase from actinomadura r39. | 1981 | 7202735 | |
| [sensitivity of actinomycetes of the genus actinomadura to antibiotics]. | sensitivity of 46 strains of actinomadura representing 27 species was studied with respect to 7 antibiotics. the minimum inhibitory concentrations of the antibiotics with respect to various species of actinomadura varied within wide ranges, i. e. from 0.1 to 100 micrograms/ml, except levorin, and antifungal antibiotic which did not inhibit the growth of any of the strains even in the highest concentration (100 micrograms/ml). the cultures of the "dassonvillei" type proved to be the most sensitiv ... | 1981 | 7259138 |
| porcine abortions associated with fungi, actinomycetes, and rhodococcus sp. | history, lesions, and results of microbiologic examinations are given for four porcine abortions associated with fungi and one each associated with actinomadura madurae, an aerobic actinomycete, and rhodococcus sp. the fungi were gliomastix sp., petriellidium boydii, aspergillus fumigatus, and exophiala jeanselmei. parvovirus, isolated from one fetus, was the only other infectious agent identified. the presence of fungi, actinomadura madurae, and rhodococcus sp. in fetal and placental lesions in ... | 1981 | 7281459 |
| the penicillin-binding site in the exocellular dd-carboxypeptidase-transpeptidase of actinomadura r39. | heat denaturation and pronase degradation of the complex previously formed between benzylpenicillin and the exocellular dd-carboxypeptidase-transpeptidase of actinomadura r39 yields a heptapeptide h-leu-pro-ala-ser-asn-gly-val-oh, where the benzylpenicilloyl group is ester-linked to the serine residue. this linkage is very labile and its hydrolysis causes the release of benzylpenicilloate. in contrast, the native benzylpenicilloyl-enzyme complex is very stable (half-life 70 h at 37 degrees c) an ... | 1981 | 7305936 |
| cationomycin, a new polyether ionophore antibiotic produced by actinomadura nov. sp. | 1981 | 7319913 | |
| rubeomycin, a new anthracycline antibiotic complex. i. taxonomy of producing organism, isolation, characterization and biological activities of rubeomycin a, a1, b and b1. | a new antibiotic complex has been obtained from the cultures of an actinomycete, strain fa-1180, isolated from a soil sample collected at lake side of biwa in japan. on the basis of taxonomic studies the producing microorganism is designated as actinomadura roseoviolacea var. biwakoensis nov. var. the antibiotic complex belongs to the class of anthracycline glycoside antibiotics. all components form deep red fine needles on crystallization; components are named rubeomycin a, a1, b and b1. these ... | 1981 | 7319927 |
| kijanimicin (sch 25663), a novel antibiotic produced by actinomadura kijaniata scc 1256. fermentation, isolation, characterization and biological properties. | a novel antibiotic complex has been isolated form the fermentation broth of a new species of actinomadura, a. kijaniata scc 1256. the complex was separated form the broth by a solvent extraction procedure and consists of 1 major component, designated kijanimicin, and 3 minor components. kijanimicin was isolated form the complex by column chromatography and/or preparative high pressure liquid chromatography. structurally the compound is a unique, large acid enol antibiotic and possesses an unusua ... | 1981 | 7328052 |
| [spontaneous l-transformation in actinomycetes]. | spontaneous l-transformation was described in actinomadura and nocardiopsis. cultures growing for two days were found to contain polymorphous cells (0.5 to 1.5 mum) lacking a cell wall. a considerable portion of the cell is occupied with a nucleoid while the cytoplasm is forced toward the periphery of the cell. membranous structures formed by five-layer membranes can be seen in the cytoplasm. budding has been observed. the above features are typical of bacterial l-forms and has not been found in ... | 1981 | 7329357 |
| interaction between non-classical beta-lactam compounds and the zn2+-containing g and serine r61 and r39 d-alanyl-d-alanine peptidases. | streptomyces albus g secretes a zn2+-containing d-alanyl-d-alanine peptidase. streptomyces r61 and actinomadura r39 secrete d-alanyl-d-alanine-cleaving serine peptidases. the effect of non-classical beta-lactam antibiotics on these three model enzymes has been studied. mecillinam, cefoxitin, quinacillin, quinacillin sulphone, clavulanate and n-formimidoylthienamycin have no effect on the zn2+-containing enzyme. 6-amino-penicillanic acid slowly inactivates this enzyme and 7-aminocephalosporanic a ... | 1981 | 6279094 |
| immunodiffusion studies of some nocardia strains. | forty-three strains of nocardia, one of actinomadura and two of nocardiopsis were studied using the comparative immunodiffusion technique. three reference precipitation systems were employed: one represented nocardia asteroides n10, one n. asteroides atcc 19247, and one n. otitidis-caviarum atcc 14629. one tight cluster was formed by the n. otitidis-caviarum strains and another tight cluster was formed by some of the n. asteroides strains studied. however, other strains of n. asteroides were dis ... | 1981 | 6798166 |
| interactions between non-classical beta-lactam compounds and the beta-lactamases of actinomadura r39 and streptomyces albus g. | 6-aminopenicillanic acid, 7-aminocephalosporanic acid, mecillinam and quinacillin have varying substrate activities for both the r39 beta-lactamase (excreted by actinomadura r39) and the g beta-lactamase (excreted by streptomyces albus g). cefoxitin and quinacillin sulphone are not recognized by the g beta-lactamase and are weak inactivators of the r39 beta-lactamase. n-formimidoylthienamycin is a poor substrate for the g beta-lactamase and a potent inactivator of the r39 beta-lactamase. the hig ... | 1981 | 6978132 |
| actinomycetoma in the united states. | actinomycetoma (madura foot) caused by actinomadura madurae occurred in an indiana factory worker. previous cases of culture-proven actinomycetoma from the united states and reports of drug therapy were reviewed. treatment with sulfonamides, streptomycin, dapsone, and other antimicrobial agents has been effective. trimethoprim-sulfamethoxazole (tmp-smz) therapy was effective in our case, but sulfadiazine was not. in vitro, smz was 16 times more active against the infecting strain of a. madurae t ... | 1981 | 6979082 |
| [incidence of actinomycetes of the genus actinomadura in the soils of kazakhstan]. | 1981 | 6455088 | |
| [actinomadura of the sierozem soils of turkmenia and their antagonistic properties]. | occurrence of actinomycetes of the genus actinomadura in the grey earth soils of turkmenistan was studied. the gause organic medium no. 2 with rubomycin proved to be most favourable for isolation of actinomadura from the soil samples. the number of actinomadura in 1 g of the soil varied from 3 to 686 000 depending on the sample which constituted 0.2-11 per cent of the total number of the actinomycetes. it was shown that actinomadura are rather widely distributed in the grey earth soils of turkme ... | 1981 | 6458232 |
| [new species of actinomadura isolated from soils in turkmenia and their antagonistic properties]. | new species, i.e. actinomadura polychroma and actinomadura umbrina are described. the cell wall of the cultures contains meso-diaminopimelic acid galactose, glucose and madurose. the former species is characterized by short spore chains in the form of spirals or pseudosporangia, smooth spore surface, white aerial mycelium and colourless, yellowish-brown or blue-green substrate mycelium. the cultures of this species have no antagonistic activity with respect to various test-microbes. the type cul ... | 1981 | 6459758 |
| [new species, actinomadura fulvescens sp. nov. and actinomadura turkmeniaca sp. nov. and their antagonistic properties]. | two new species of actinomadura isolated from soil samples of the turkmen ssr, i.e. actinomadura fulvescens sp. nov. and actinomadura turkmeniaca sp. nov. are described. the first species is characterized by formation of short (1-2 turns) spiral spore chains, smooth spores, scanty white aerial mycelium, colourless or yellowish substrate mycelium on synthetic media and brownish-yellow substrate mycelium and soluble pigment of the same colour on organic media. no melanoid pigment is secreted. the ... | 1982 | 6461291 |
| [mutagenesis in streptomycete cultures exposed to bleomycin]. | mutagenic properties of bleomycin, an antitumor antibiotic were studied with respect to 2 species of streptomycetes producing practically important antibiotics. a multifold increase in the frequency of prototrophic revertants among the survivors of strains his- and met- of actinomadura carminata exposed to bleomycin was observed. bleomycin was effective in induction of various morphological mutants, and auxotrophs at a high survival rate of the spores of str. cremeus var. tobramycini, a tobramyc ... | 1982 | 6175272 |
| delta 2- and delta 3-cephalosporins, penicillinate and 6-unsubstituted penems. intrinsic reactivity and interaction with beta-lactamases and d-alanyl-d-alanine-cleaving serine peptidases. | the intrinsic reactivity of delta 2- and delta 3-deacetoxy-7-phenylacetamidocephalosporanates, penicillanate, unsubstituted, 2-methyl- and 2-phenyl-penems and other beta-lactam antibiotics has been expressed in terms of the second-order rate constant (m-1.s-1(oh-)) for the hydrolysis of the beta-lactam amide bond by oh- at 37 degrees c. the values thus obtained have been compared with the second-order rate constants (m-1.s-1(enzyme) for the opening of the same beta-lactam amide bond during inter ... | 1982 | 6980645 |
| interaction of clavulanate with the beta-lactamases of streptomyces albus g and actinomadura r39. | the reactions of beta-lactamases of actinomadura r39 and streptomyces albus g with clavulanate proceed along branched pathways. both enzymes perform the hydrolysis of this beta-lactam with rather high efficiencies (kcat. = 18s-1 and 52s-1 respectively). if large clavulanate/enzyme ratios are used, complete inactivation of the enzymes is observed. at lower ratios, inactivation is only partial. irreversible inactivation occurs after 400 and 20000 turnovers for the a. r39 and s. albus g enzymes res ... | 1982 | 6984651 |
| interaction of beta-iodopenicillanate with the beta-lactamases of streptomyces albus g and actinomadura r39. | the beta-lactamases of streptomyces albus g and actinomadura r39 are inactivated by beta-iodopenicillanate. however, in contrast with the beta-lactamase i from bacillus cereus, they also efficiently catalyse the hydrolysis of the inactivator; with the s. albus g enzyme, kcat. is larger than 25s-1 and the number of turnovers before inactivation is 515. with the a. r39 enzyme, kcat. is larger than 50s-1 and the number of turnovers before inactivation is 80. after hydrolysis of the beta-lactam amid ... | 1982 | 6299270 |
| [transfer of species of the genus actinomadura lechevalier et lechevalier 1970 to the genus nocardiopsis meyer 1976]. | the type cultures of four actinomadura species (a. africana, a. coeruleofusca, a. flava, a. longispora) were studied and compared with the type culture belonging to the genus nocardiopsis. in their morphological properties and in the composition of the cell wall, these cultures were shown to be closer to the genus nocardiopsis meyer 1976 rather than to the genus actinomadura lechevalier et lechevalier 1970. basing on these data, the species have been transferred to the genus nocardiopsis. | 1982 | 7070303 |
| numerical classification of sporoactinomycetes containing meso-diaminopimelic acid in the cell wall. | one hundred and thirty actinomycetes representing 19 genera and 50 species were compared in a numerical phenetic survey using 108 unit characters. data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using both the single and unweighted pair group average algorithms. cluster composition was barely affected by the statistics used or by test error, estimated at 2.1%. over 80% of the strains were assigned to 2 clusters containing ... | 1982 | 7077300 |
| sporotrichosis-like mycetoma caused by actinomadura madurae. | 1982 | 7133047 | |
| [number, species composition and antagonistic properties of actinomadura from soddy-podzolic soils and from soils in the tundra zone]. | occurrence of actinomadura in the turf-podzol soils of the moscow region and in the tundra soils of taimir was studied. it was found that there were practically no actinomadura in the tundra soils, while their occurrence in the turf-podzol soils was rather high and amounted to 5 per cent of the actinomycetous flora. the occurrence of actinomadura in cultured soils was higher and their species composition was more diverse as compared to those in virgin lands. the isolates represented 10 species a ... | 1982 | 7149690 |
| [distribution of actinomycetes of the genus actinomadura in the light chestnut soils of volgograd province and their antagonistic properties]. | prevalence of the actinomycetes of the actinomadura genus in the virgin and cultivated light chestnut soils of the volgograd region was studied. it was shown that actinomadura were one of the constituents of the actinomycetous flora of these soils. no significant changes in the number of the actinomadura and the total number of the actinomycetes were observed in the cultivated and virgin soils. the cultures of actinomadura isolated from the virgin and cultivated soils belonged to 17 and 18 known ... | 1982 | 6217783 |
| purification and properties of the exocellular beta-lactamase of actinomadura strain r39. | the exocellular beta-lactamase (penicillin amido-beta-lactamhydrolase, ec 3.5.2.6) of actinomadura r39 consists of one single polypeptide chain of molecular weight about 15 200. it exhibits a highly asymmetrical shape, has a low isoelectric point (at ph 5.0) and contains about 9.3% (w/w) of a polydeoxyribonucleotide with which it forms a rather stable complex. removal of a substantial amount of this deoxyribonucleotide by treatment with dnaase i has no effect on the enzyme activity. the beta-lac ... | 1982 | 6976797 |
| madura foot by actinomadura madurae. a further report on an autochthonous italian case. | 1983 | 6888420 | |
| molecular-genetic and chemotaxonomic studies on actinomadura and nocardiopsis. | the relationships of 24 strains of 13 species of actinomadura and 4 strains of nocardiopsis dassonvillei were determined by nucleic acid hybridization studies. dna-rrna cistron similarity and dna homology values reveal that actinomadura is genetically heterogeneous. one cluster contained the type species actinomadura madurae, actinomadura pelletieri, actinomadura verrucosospora, actinomadura malachitica, actinomadura citrea and 'actinomadura kijaniata'. a second cluster embraced actinomadura pus ... | 1983 | 6198437 |
| numerical classification of streptomyces and related genera. | four hundred and seventy-five strains, which included 394 type cultures of streptomyces and representatives of 14 other actinomycete genera, were studied. overall similarities of these strains for 139 unit characters were determined by the ssm and sj coefficients and clustering by the upgma algorithm. test error and overlap between the phena defined were within acceptable limits. cluster-groups were defined by the ssm coefficient at the 70.1% similarity (s) level and by the sj coefficient at the ... | 1983 | 6631406 |
| sugar-containing lipids in the classification of representative actinomadura and nocardiopsis species. | the major sugar-containing lipids of some actinomadura and nocardiopis strains--recognized as an important agent of actinomycetoma -- were analyzed by thin-layer and gas-liquid chromatography. it was demonstrated that nocardiopsis dassonvillei strains contained two characteristic glycolipids identified as monomannosyl diglyceride and monoacylated glucose. none of them was found in the representatives of actinomadura madurae and actinomadura pelletieri strains, which possessed phosphatidylinosito ... | 1983 | 6651478 |
| a new species of actinomadura producing a polyether antibiotic, cationomycin. | taxonomic studies on the new species, actinomadura azurea are presented. a significant property of this species is the production of a new polyether antibiotic, cationomycin. | 1983 | 6654756 |
| a serological survey of antibodies to streptomyces somaliensis and actinomadura madurae in the sudan enzyme linked immunosorbent assay (elisa). | sera from 160 individuals resident in the gezira, and 40 living in khartoum, sudan, were screened for antibodies to streptomyces somaliensis and actinomadura madurae using enzyme linked immunosorbent assay (elisa). antibodies were detected in 11.2% of those from the gezira (6.8% to s. somaliensis, 4.3% to a. madurae, and 0.6% to both) compared to 2.5% of those resident in khartoum. the ratio of men with antibodies compared to women was about 2:1 in those from gezira. the results encouraged furth ... | 1983 | 6679364 |
| [new species of actinomadura recticatena sp. nov. and its antibiotic properties]. | actinomadura cultures were isolated from soil samples collected in turkmenistan, the moscow, kursk and volgograd regions. the cultures were described as representatives of a new species (actinomadura recticatena, preobrazhenskaya et galatenko, sp. nov). the hydrolysates of intact cells of the cultures contain mesodiaminopumelic acid, galactose and madurose. the species is characterized by straight spore chains, wrinkled spore surface, cream-colored aerial mycelium and brown substrate mycelium wi ... | 1984 | 6696399 |
| oxanthromicin, a novel antibiotic from actinomadura. | 1984 | 6725146 | |
| a new antiviral antibiotic sf-2140 produced by actinomadura. | 1984 | 6090375 | |
| isolation and characterization of i5b2, a new phosphorus containing inhibitor of angiotensin i converting enzyme produced by actinomadura sp. | a new inhibitor of angiotensin i converting enzyme, i5b2, was isolated from the culture broth of actinomadura sp. no. 937ze-1. this compound contains n-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. the microorganism also produced another inhibitor, i5b1, which is identical with k-4 isolated from actinomadura sp. as an antihypertensive agent. | 1984 | 6094415 |
| cl 259,971: a potent new polyether anticoccidial. 1. battery efficacy and safety. | the anticoccidial activity of cl 259,971, a new polyether ionophore produced by actinomadura yumaense sp. nov, has been demonstrated against six species of poultry eimeria, tested individually or in mixed species infections. statistically significant activity was obtained against some species with as little as 2.5 ppm of drug. the optimal treatment level, however, was determined to be 5 ppm. at this level, performance was comparable to 100 or 120 ppm of monensin. cl 259,971 is coccidiocidal and ... | 1984 | 6483715 |
| biosynthesis of the antibiotic maduramicin. origin of the carbon and oxygen atoms as well as the 13c nmr assignments. | the biosynthesis of maduramicin alpha and beta in a culture of actinomadura yumaensis has been studied using 13c, 14c and 18o labeled precursors. the alpha component of this recently discovered polyether antibiotic, containing forty-seven carbon atoms in a seven-ring system, is derived from eight acetate, seven propionate and four methionine molecules. the beta component which is missing one methoxy group incorporates three methionine methyl groups. the carbohydrate moiety was enriched by methio ... | 1984 | 6526733 |
| a new indole n-glycoside antibiotic sf-2140 from an actinomadura. i. taxonomy and fermentation of producing microorganism. | a new indole n-glycoside antibiotic sf-2140 which shows antiviral and weak antibacterial activity has been obtained from the cultured broth of an actinomycete strain. strain sf-2140, designated actinomadura albolutea sp. nov., was isolated from a soil sample collected in hyogo prefecture, japan. | 1984 | 6548734 |
| des-, syn- and anti-oxyimino-delta 3-cephalosporins. intrinsic reactivity and reaction with rtem-2 serine beta-lactamase and d-alanyl-d-alanine-cleaving serine and zn2+-containing peptidases. | the presence and configuration (syn or anti) of an oxyimino group in the 7 (beta)-acyl side chain of 3-cephems do not modify the intrinsic reactivity of the beta-lactam ring, but have highly enzyme-specific effects. when compared with the corresponding desoxyimino beta-lactam compound: (i) with the plasmid-mediated escherichia coli rtem-2 serine beta-lactamase, the substrate activity of the anti isomer is increased and that of the syn isomer is decreased; (ii) with the streptomyces r61 serine d- ... | 1984 | 6609701 |
| enzymatic preparation of an immunostimulant, the disaccharide-dipeptide, n-acetyl-beta-d-glucosaminyl-(1----4)-n-acetylmuramyl-l-alanyl-d-is ogl utamine, from a bacterial peptidoglycan. | the disaccharide-dipeptide n-acetyl-beta-d-glucosaminyl-(1----4)-n-acetylmuramyl-l-alanyl-d-isog lut amine has been obtained by an enzymatic degradation of the peptidoglycan of actinomadura r39. the peptidoglycan was hydrolyzed successively by the three following enzymes: lysozyme, dd-carboxypeptidase from streptomyces albus g and gamma-d-glutamyl-meso-diaminopimelate endopeptidase i from bacillus sphaericus 9602. the by-products of the last reaction were eliminated by successive ion-exchange an ... | 1984 | 6381058 |
| adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties. | adechlorin exhibiting a potent inhibitory activity against calf intestinal adenosine deaminase was isolated from the cultured broth of actinomadura sp. omr-37. the molecular formula was c11h15n4o4cl. the aglycone of adechlorin was identical with that of the known adenosine deaminase inhibitors coformycin and 2'-deoxycoformycin. adechlorin did not exhibit inhibitory activity against various bacteria and fungi at 1.0 mg/ml. the ki values for adechlorin, coformycin and 2'-deoxycoformycin against ad ... | 1985 | 3840153 |
| potent antitumor antibiotic complex: pd 114,759, pd 115,028, pd 119,707, and pd 119,193. | four novel antitumor antibiotics (pd 114,759, pd 115,028, pd 119,707 and pd 119,193) are produced as a complex by a new species of actinomadura. the proposed name for the culture is actinomadura verrucosospora subsp. veractimyces atcc 39363. the antibiotics are extremely bioactive, with mic values of less than 0.006 ng/ml against several bacteria and id50 values of 0.003 approximately 0.107 ng/ml against l1210 leukemia cells in vitro. antitumor activities vs. p388 leukemia in vivo were observed ... | 1985 | 3840793 |
| [enzyme inhibitors from actinomycetes. ii. acid protease inhibitors]. | in the course of a screening program directed toward the isolation and evaluation of inhibitors of carboxyl (acid) proteinases, we have found 0.39% of the investigated strains of microorganisms as producers of pepsin inhibitors. in more than 1543 strains which were isolated from various geographical areas and deposited with the imet culture collection, jena-gdr, and which belong to different genera of actinomycetes such as streptomyces, actinomadura, actinoplanes, micromonospora and non-identifi ... | 1985 | 3930695 |
| 2'-chloropentostatin: discovery, fermentation and biological activity. | 2'-chloropentostatin (2-cp) is a new nucleoside antibiotic produced by actinomadura sp. atcc 39365. a selectively sensitive assay organism, enterococcus faecalis pd 05045 (mic 0.005 micrograms/ml) was instrumental in the discovery of this compound. 2-cp is a tight-binding inhibitor of adenosine deaminase (ki = 1.1 x 10(-10) m). | 1985 | 3934118 |