Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| astragaloside iv inhibits pma-induced epcr shedding through mapks and pkc pathway. | astragaloside iv (as-iv), a main active substance isolated from astragalus membranaceus bunge, has been shown to have multiple pharmacological effects. endothelial cell protein c receptor (epcr) is a marker of inflammation, and is also a major member of protein c (pc) anti-coagulation system. epcr can be cut off from the cell surface by tumor necrosis factor-α converting enzyme (tace), which is controlled through mitogen-activated protein kinase (mapk) and protein kinase c (pkc) pathways. to dev ... | 2017 | 28367652 |
| pg2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study. | pg2 is an infusible polysaccharide extracted from astragalus membranaceus, which is a chinese herb traditionally used for stroke treatment. we investigated the effect of pg2 on patients with spontaneous acute intracerebral hemorrhage (ich). a total of 61 patients with acute spontaneous ich were randomized to either the treatment group (tg, 30 patients), which received 3 doses of pg2 (500 mg, iv) per week for 2 weeks, or the control group (cg, 31 patients), which received pg2 placebo. at 84 days ... | 2017 | 28361971 |
| effect of chinese herbal medicine treatment on plasma lipid profile and hepatic lipid metabolism in hetian broiler. | the purpose of this study was to investigate whether adding a chinese herbal hedicine (chm, including astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, fructus crataegi, folium epimedii, radix saposhnikoviae, and pericarpium citri reticulatae) diet has effects on lipid metabolism in the liver of the broiler. six-hundred-thirty hetian broilers were divided into 3 groups including base diet (control), 0.3%, or 1% chm diets, for 130 days. the results showed th ... | 2017 | 28339712 |
| effects and mechanisms of compound chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion. | microcirculation dysfunction and organ injury after ischemia and reperfusion (i/r) result from a complex pathologic process consisting of multiple links, with metabolism impairment in the ischemia phase and oxidative stress in the reperfusion phase as initiators, and any treatment targeting a single link is insufficient to cope with this. compound chinese medicine (ccm) has been applied in clinics in china and some asian nations for more than 2000 years. studies over the past decades revealed th ... | 2017 | 28322971 |
| astragaloside iv inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis. | cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. astragaloside iv (asiv) is a major active ingredient in astragalus membranaceus. in a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotective effects via preventing cardiomyocyte hypertrophy and apoptosis. the present study aimed to investigate the effects of asiv on β‑adrenergic receptor (β‑ar)‑mediated cardiac fibr ... | 2017 | 28260010 |
| antibacterial evaluation of sliver nanoparticles synthesized by polysaccharides from astragalus membranaceus roots. | this work introduced an eco-friendly approach for the synthesis of sliver nanoparticles (agnps) with a water-soluble fraction of polysaccharides extracted from the roots of astragalus membranaceus (amwp). amwp mediated agnps (amwp-agnps) were successfully synthesized using 1.0mm agno3 and 1.25mg/ml amwp, reacting in aqueous environment at 25°c for 6h. the synthesized amwp-agnps exhibited a broad surface plasmon resonance peak (spr) at 445nm in ultraviolet-visible (uv-vis) spectrum, which was cha ... | 2017 | 28242544 |
| ensifer shofinae sp. nov., a novel rhizobial species isolated from root nodules of soybean (glycine max). | two bacterial strains isolated from root nodules of soybean were characterized phylogenetically as members of a distinct group in the genus ensifer based on 16s rrna gene comparisons. they were also verified as a separated group by the concatenated sequence analyses of reca, atpd and glnii (with similarities ≤93.9% to the type strains for defined species), and by the average nucleotide identities (ani) between the whole genome sequence of the representative strain ccbau 251167(t) and those of th ... | 2017 | 28209394 |
| astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting nf-κв activation. | astragalus polysaccharide (aps) is a bioactive extract of astragalus membranaceus (am), which possess a wide range of medicinal benefits, including anti-inflammatory, anti-oxidative, anti-tumor and anti-diabetic effects. the present work evaluated the therapeutic effect of aps and its potential mechanisms in a mouse model of dextran sulfate sodium (dss)-induced colitis. the aps treatment led to significant improvements in colitis disease activity index (dai) and histological scores, as well as s ... | 2017 | 28188801 |
| formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of mir-21 and pten. | the isoflavone formononetin is the main active component of astragalus membranaceus and possesses anti-tumorigenic properties. however, the role of formononetin in human bladder cancer (bca) has not been fully elucidated. the aim of the present study was to investigate the anti-tumor effects of formononetin on bca cells and its potential molecular mechanism. t24 cells were treated with different concentrations of formononetin, and then the cell proliferation was assessed by mtt assay, cell apopt ... | 2017 | 28139790 |
| chinese herbal drugs for the treatment of diabetic retinopathy. | to explore the various pharmacological actions and the molecular mechanisms behind them by which chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression. | 2017 | 28124440 |
| therapeutic effects of qian-yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats. | qian-yu decoction (qyd) is a traditional chinese medicinal recipe composed of radix astragali (astragalus membranaceus (fisch.) bunge var. mongholicus (bunge) p.k. hsiao, fabaceae ), herba epimedii (epimedium brevicornum maxim., berberidaceae), herba leonuri (leonurus japonicus houtt., lamiaceae), cortex phellodendri (phellodendron chinense schneid., rutaceae) and radix achyranthis bidentatae (achyranthes bidentata bl., amaranthaceae). this study aimed to evaluate the therapeutic activity of qyd ... | 2017 | 28122556 |
| luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/jak2/stat3 pathway in cardiomyocytes. | luhong formula (lhf)-a traditional chinese medicine containing cervus nippon temminck, carthamus tinctorius l., cinnamomum cassia presl, codonopisis pilosula( franch.) nannf., astragalus membranaceus ( fisch.) bge. var. mongholicus ( bge.) hsiao, lepidium apetalum willd-is used in the treatment of heart failure. | 2017 | 28115285 |
| protective effects of total flavonoids of astragalus against adjuvant-induced arthritis in rats by regulating opg/rankl/nf-κb pathway. | astragalus membranaceus bunge is one of the oldest and most frequently used crude herbs in traditional chinese medicine. the total flavonoids of astragalus (tfa) are the main active components isolated from astragalus membranaceus bunge. our recent study has shown its potential immunomodulatory and anti-inflammatory effects in vivo and in vitro. however, its anti-arthritic effects and mechanisms of action involved have not been elucidated. the aim of this study was to evaluate the protective eff ... | 2017 | 28092862 |
| low-cost magnetic herbal biochar: characterization and application for antibiotic removal. | magnetic biochar (m-bc) was derived from herbal medicine waste, astragalus membranaceus residue, and was used as an adsorbent for ciprofloxacin removal from aqueous solutions. the m-bc was characterized by brunauer-emmett-teller surface area analyses, fourier transform infrared spectrometry, x-ray diffraction analysis, hysteresis loops, scanning electron microscopy energy-dispersive spectrometry, and x-ray photoelectron spectroscopy. the bet surface area increased from 4.40 to 203.70 m(2)/g afte ... | 2017 | 28083746 |
| astragaloside iv attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. | astragaloside iv (as-iv) is the main active component isolated from the traditional chinese medicinal herb astragalus membranaceus. studies have demonstrated that as-iv has neuroprotective effects in cerebral ischemic models. in this study, we aimed to investigate the effects of as-iv on memory impairment induced by transient cerebral ischemia and reperfusion in mice, as well as the associated signaling mechanisms. severe memory deficits were induced by bilateral common carotid artery occlusion ... | 2017 | 28011393 |
| astragaloside iv enhances cisplatin chemosensitivity in non-small cell lung cancer cells through inhibition of b7-h3. | chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (nsclc). astragaloside iv, the component of astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and immunoregulatory properties. in the present study, we investigated the role of astragaloside iv in the chemoresistance to cisplatin in nsclc cells. | 2016 | 27960166 |
| sh003 induces apoptosis of du145 prostate cancer cells by inhibiting erk-involved pathway. | herbal medicines have been used in cancer treatment, with many exhibiting favorable side effect and toxicity profiles compared with conventional chemotherapeutic agents. sh003 is a novel extract from astragalus membranaceus, angelica gigas, and trichosanthes kirilowii maximowicz combined at a 1:1:1 ratio that impairs the growth of breast cancer cells. this study investigates anti-cancer effects of sh003 in prostate cancer cells. | 2016 | 27927199 |
| astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity. | doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. previous studies demonstrated that astragalus polysaccharide (aps), the extracts of astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. however, whether aps could mitigate chemotherapy-induced cardiotoxicity is unclear ... | 2017 | 27902477 |
| ameliorating effect of erxian decoction combined with fructus schisandrae chinensis (wu wei zi) on menopausal sweating and serum hormone profiles in a rat model. | modified erxian decoction (mexd), i.e., erxian decoction (exd) with fructus schisandrae chinensis (wu wei zi) added, has been used to alleviate menopausal symptoms. this study aimed to investigate the effects of mexd on menopausal sweating and serum hormone levels in a rat model of menopause after oral administration of mexd. | 2016 | 27895702 |
| astragalus polysaccharide suppresses 6-hydroxydopamine-induced neurotoxicity in caenorhabditis elegans. | astragalus membranaceus is a medicinal plant traditionally used in china for a variety of conditions, including inflammatory and neural diseases. astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat parkinson's disease (pd). however, the neuroprotective effect of astragalus polysaccharides per se in pd is lacking. using caenorhabditis elegans models, we investigated the protective effect of astragalan, an acidic polysaccharide isolated from a. memb ... | 2016 | 27885333 |
| effects of astragalus membranaceus, codonopsis pilosula and allicin mixture on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. | a 12-week trial with 120 [(landrace×yorkshire)×duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of astragalus membranaceus, codonopsis pilosula and allicin mixture (hm) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. pigs were allocated to one of three treatments with 0, 0.025% (hm1) and 0.05% (hm2) hm supplementation in a randomized complete block design according to sex and bw. each ... | 2016 | 27868250 |
| astragaloside iv from astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via tlr4/nf-кb in vivo and in vitro. | renal fibrosis is characterized by infiltration of inflammatory cells, activation and proliferation of fibroblasts, and accumulation of extracellular matrix (ecm). astragalus membranaceus (am) is traditional chinese medicine and has a range of pharmacological effects. astragaloside iv (as iv) is the main compound of am and has anti-inflammation activities. whether as iv ameliorates renal interstitial fibrosis by inhibiting inflammation remains unknown. accordingly, this study investigated the am ... | 2017 | 27855303 |
| neuroprotective effect of a novel chinese herbal decoction on cultured neurons and cerebral ischemic rats. | historically, traditional chinese medicine has been widely used to treat stroke. based on the theory of chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called post-stroke rehabilitation (psr), comprising seven herbs - astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, paeonia lactiflora pall., cassia obtusifolia l., ligusticum chuanxiong hort., angelica sinensis (oliv.) diels, and glycyrrhiza uralensis fisc ... | 2016 | 27814708 |
| effects of the traditional chinese herb astragalus membranaceus in patients with poststroke fatigue: a double-blind, randomized, controlled preliminary study. | astragalus membranaceus (am) is the first-choice herb for fatigue treatment in traditional chinese medicine and the main herb used for stroke treatment in china and taiwan. the purpose of this study was to evaluate the effect of am on poststroke fatigue (psf). | 2016 | 27773802 |
| formononetin, an active compound of astragalus membranaceus (fisch) bunge, inhibits hypoxia-induced retinal neovascularization via the hif-1α/vegf signaling pathway. | it has been reported that formononetin (fmn), one of the main ingredients from famous traditional chinese medicine "huang-qi" (astragalus membranaceus [fisch] bunge) for qi-tonifying, exhibits the effects of immunomodulation and tumor growth inhibition via antiangiogenesis. furthermore, a. membranaceus may alleviate the retinal neovascularization (nv) of diabetic retinopathy. however, the information of fmn on retinal nv is limited so far. in the present study, we investigated the effects of fmn ... | 2016 | 27729769 |
| comparison of the anti-duck hepatitis a virus activities of phosphorylated and sulfated astragalus polysaccharides. | duck hepatitis a virus (dhav) (picornaviridae) causes an infectious disease in ducks which results in severe losses in duck industry. however, the proper antiviral supportive drugs for this disease have not been discovered. polysaccharide is the main ingredient of astragalus that has been demonstrated to directly and indirectly inhibit rna of viruses replication. in this study, the antiviral activities of astragalus polysaccharide (aps) and its derivatives against dhav were evaluated and compare ... | 2017 | 27703041 |
| astragaloside iv ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin d3-upregulated protein 1/nf-κb signaling pathway. | astragaloside iv (as-iv) is a flavonoid from the plant astragalus membranaceus (fisch) bge that has a wide range of therapeutic effects. the aim of the present study was to examine the effect of as-iv on rats with necrotizing enterocolitis (nec) under oxidative stress and inflammation. newborn sprague-dawley rats were induced with nec by asphyxia and hypothermia applied on 3 consecutive days. the rats were orally administered as-iv at 25, 50 and 75 mg/kg for 4 days. the results revealed that as- ... | 2016 | 27698775 |
| comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells. | polysaccharides from different types of natural herbs have not been compared with each other to determine their differential potencies on innate immune response, such as maturation of dendritic cells (dc). in addition, the role of endocytosis of polysaccharides in dc maturation has not been explored previously. polysaccharides isolated from astragalus membranaceus (aps), ganoderma lucidum (glp) and radix ophiopogonis (ogp) were characterized and applied in bone marrow derived dc. compared to imm ... | 2016 | 27659001 |
| astragalus polysaccharide modulates er stress response in an ova-lps induced murine model of severe asthma. | endoplasmic reticulum (er) stress has been recently revealed to play a pivotal role in the pathogenesis of severe asthma. astragalus polysaccharide (aps), a major bioactive component from astragalus membranaceus, exerts immunomodulatory and anti-inflammatory effects and has been shown to suppress er stress in chronic diseases such as type-2 diabetes. however, the pharmaceutical application of aps in the treatment of severe asthma is unknown. the results obtained here indicate that aps significan ... | 2016 | 27645929 |
| post-hematopoietic stem cell transplantation in patients with hematologic disorders: chinese herbal medicine for an unmet need. | while much progress has been made in the field of hematopoietic stem cell transplantation (hsct), headway in the promotion of recovery following this procedure has been limited. data regarding the potential of chinese herbal medicine (chm) for patients with hematologic disorders who received hsct are gradually increasing; however, these data are mostly in chinese. therefore, we set out to summarize the existing data. we searched pubmed, the cochrane library and the china national knowledge infra ... | 2016 | 27641605 |
| astragalus polysaccharide attenuated iron overload-induced dysfunction of mesenchymal stem cells via suppressing mitochondrial ros. | bone marrow-derived mesenchymal stem cells (bmscs) have the ability to differentiate into multilineage cells such as osteoblasts, chondrocytes, and cardiomyocytes. dysfunction of bmscs in response to pathological stimuli participates in the development of diseases such as osteoporosis. astragalus polysaccharide (aps) is a major active ingredient of astragalus membranaceus, a commonly used anti-aging herb in traditional chinese medicine. the aim of this study was to investigate whether aps protec ... | 2016 | 27607448 |
| suppressive effect of formononetin on platelet-derived growth factor-bb-stimulated proliferation and migration of vascular smooth muscle cells. | abnormal proliferation and migration of vascular smooth muscle cells (vsmcs) has been implicated in intimal hyperplasia, atherosclerosis and restenosis following percutaneous coronary intervention. formononetin, a phytoestrogen extracted from the root of astragalus membranaceus, has been widely used in chinese tradition medicine due to its protective effects against certain symptoms of cancer, hypertension, inflammation, hypoxia-induced cytotoxicity and ovariectomy-induced bone loss. however, th ... | 2016 | 27588108 |
| research review on the pharmacological effects of astragaloside iv. | astragalus membranaceus bunge has been used to treat numerous diseases for thousands of years. as the main active substance of astragalus membranaceus bunge, astragaloside iv (as-iv) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. based on studies published during the past several decades, the current state of as-iv research and the pharmacological effects are detailed, elu ... | 2017 | 27567103 |
| astragaloside iv attenuates inflammatory reaction via activating immune function of regulatory t-cells inhibited by hmgb1 in mice. | high-mobility group box 1 (hmgb1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. some experiments have demonstrated a vital role for hmgb1 to modulate the immune function of regulatory t-cells (tregs). astragaloside iv (ast iv), an extract from astragalus membranaceus moench (leguminosae), has been shown to exert potent cardioprotective and anti-inflammatory effects. it is still unclear whether ast iv has a latent effect on the proinflammatory ability of ... | 2016 | 27564970 |
| hepatoprotective activity of an herbal composition, map, a standardized blend comprising myristica fragrans, astragalus membranaceus, and poria cocos. | historically, botanicals have been reported to possess good antioxidative activities as demonstrated by their free radical scavenging property rendering their usage in liver protection. in this study, we describe the potential use of map, a standardized blend comprising three extracts from myristica fragrans, astragalus membranaceus, and poria cocos, in ameliorating chemically induced acute liver toxicities. acetaminophen (apap) and carbon tetrachloride (ccl4)-induced acute liver toxicity models ... | 2016 | 27564381 |
| sh003 suppresses breast cancer growth by accumulating p62 in autolysosomes. | drug markets revisits herbal medicines, as historical usages address their therapeutic efficacies with less adverse effects. moreover, herbal medicines save both cost and time in development. sh003, a modified version of traditional herbal medicine extracted from astragalus membranaceus (am), angelica gigas (ag), and trichosanthes kirilowii maximowicz (tk) with 1:1:1 ratio (w/w) has been revealed to inhibit tumor growth and metastasis on highly metastatic breast cancer cells, both in vivo and in ... | 2016 | 27556358 |
| preparation and characterization of a novel astragalus membranaceus polysaccharide-iron (iii) complex. | astragalus membranaceus polysaccharide-iron (iii) complex (aps-iron) was synthesized and characterized. based on single factor and response surface optimization experiments of aps-iron (iii) complex synthesis, the optimum conditions of aps-iron (iii) complex were obtained as follows: the reaction temperature 89.46°c, ph 8.16, reaction time 46.04min and ratio of catalyst to aps 0.75, respectively. the reaction temperature was the most significant factor, followed by ph, reaction time and the rati ... | 2016 | 27544435 |
| improved survival with integration of chinese herbal medicine therapy in patients with acute myeloid leukemia: a nationwide population-based cohort study. | purpose acute myeloid leukemia (aml) is the most deadly subtype of leukemia, and many patients with this disease seek other complementary therapies, one of which is chinese medicine. we set out to provide reliable data regarding the benefit of chinese herbal medicine (chm) for aml patients, using mortality as the main outcome measure. we also characterized the herbal prescriptions of patients. methods using the taiwanese national health insurance research database, we performed a nationwide popu ... | 2016 | 27531548 |
| deacetylation biocatalysis and elicitation by immobilized penicillium canescens in astragalus membranaceus hairy root cultures: towards the enhanced and sustainable production of astragaloside iv. | a novel biotechnology approach by combining deacetylation biocatalysis with elicitation of immobilized penicillium canescens (ipc) in astragalus membranaceus hairy root cultures (amhrcs) was proposed for the elevated production of astragaloside iv (ag iv). the highest ag iv accumulation was achieved in 36-day-old amhrcs co-cultured with ipc for 60 h, which resulted in the enhanced production of ag iv by 14.59-fold in comparison with that in control (0.193 ± 0.007 mg/g dw). meanwhile, ag iv precu ... | 2017 | 27518481 |
| comparison of critical methods developed for fatty acid analysis: a review. | fatty acids are important nutritional substances and metabolites in living organisms. these acids are abundant in chinese herbs, such as brucea javanica, notopterygium forbesii, isatis tinctoria, astragalus membranaceus, and aconitum szechenyianum. this review illustrates the types of fatty acids and their significant roles in the human body. many analytical methods are used for the qualitative and quantitative evaluation of fatty acids. some of the methods used to analyze fatty acids in more th ... | 2017 | 27471181 |
| effects of astragalus polysaccharides on memory impairment in a diabetic rat model. | astragalus polysaccharides (aps) are active constituents of astragalus membranaceus. in this study, we aimed to investigate the effects of aps on memory impairment in a diabetic rat model and their mechanisms. | 2016 | 27445477 |
| astragalus membranaceus augment sperm parameters in male mice associated with camp-responsive element modulator and activator of crem in testis. | astragalus membranaceus bunge (am; huáng qí) has been widely used as a medicinal herb for different kinds of diseases. am treatment in vitro enhance sperm motility and ameliorates testicular toxicity, it has demonstrated the ability as a potential treatment for male infertility. in order to gain further insights on the molecular understanding of how am enhances spermatogenesis, this study investigated whether am has an affect on sperm parameters associated with camp response element modulator (c ... | 2016 | 27419096 |
| astragaloside i stimulates osteoblast differentiation through the wnt/β-catenin signaling pathway. | astragaloside i (as-i), one of the main active ingredients in astragalus membranaceus, is believed to have osteogenic properties, but this hypothesis has not been investigated in detail. in the present work, the as-i-induced osteogenic effects and its underlying mechanism were studied in mc3t3-e1 cells. the results indicated that the cellular levels of alp and extracellular matrix calcium increased in a dose-dependent manner by as-i. to clarify the mechanisms involved in this process, the effect ... | 2016 | 27397144 |
| simultaneous determination of six active metabolites in astragalus mongholicus (fisch.) bge. under salt stress by ultra-pressure liquid chromatography with tandem mass spectrometry. | astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus, family leguminosae) is one of the most important traditional chinese herbs because it contains lots of bioactive metabolites, which have beneficial and pharmacological effects on health. simultaneously, it has been proved to be a salt-tolerant plant-one of the potential species to control the soil salinization. therefore, a sensitive and specific ultra-pressure liquid chromatography coupled with tandem mass spectrometric ... | 2016 | 27386371 |
| a standardized composition from extracts of myristica fragrans, astragalus membranaceus, and poria cocos protects liver from acute ethanol insult. | despite the promising advances in therapeutic discovery, there still is a major challenge in the development of a safe, effective, and economical intervention for managing alcohol-related liver disorders. in this study, we describe the potential use of "map," a standardized composition comprising three extracts from myristica fragrans, astragalus membranaceus, and poria cocos, in ameliorating alcohol-induced acute liver toxicity. ethanol-induced acute hepatotoxicity as an animal model of binge d ... | 2016 | 27355692 |
| [investigation on main cultivation of astragalus membranaceus var. mongholicus and commercial specifications grades]. | to investigate the main cultivation areas of astragalus membranaceus var. mongholicus, and to clarify its present cultivation status and commercial specification grades. | 2015 | 27352529 |
| protective effects of astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol. | astragalus polysaccharide (aps) is an important bioactive component extracted from chinese herb astragalus membranaceus. it has been widely used in treatment of cardiovascular diseases. we have previously reported that aps could inhibit isoproterenol-induced cardiac hypertrophy. the present study was designed to evaluate the protective effect of aps on vascular endothelia in cardiac hypertrophy rats induced by isoproterenol (iso). iso (10mg×kg(-1)) was intraperitoneally injected once daily for 2 ... | 2016 | 27344039 |
| integrative traditional chinese medicine therapy reduces the risk of diabetic ketoacidosis in patients with type 1 diabetes mellitus. | life-long insulin is the standard treatment for type 1 diabetes mellitus (t1dm). the role of traditional chinese medicine (tcm) in t1dm is still not clear. the aim of this study is to explore the prescription pattern of tcm and its impact on the risk of diabetic ketoacidosis (dka) in patients with t1dm. | 2016 | 27340102 |
| astagalus polysaccharide attenuates murine colitis through inhibiton of the nlrp3 inflammasome. | astragalus polysaccharide is an important bioactive component of astragalus membranaceus, an herb used in traditional chinese medicine for treating inflammatory bowel disease. the nod-like receptor protein 3 inflammasome plays an important role in the pathogenesis of inflammatory bowel disease. however, little is known about the role of nod-like receptor protein 3 inflammasome in astragalus polysaccharide-treated mice with experimental colitis. for this study, we investigated the molecular mecha ... | 2017 | 27280937 |
| astragalus polysaccharide induces the apoptosis of human hepatocellular carcinoma cells by decreasing the expression of notch1. | hepatocellular carcinoma (hcc) is the third most frequent cause of cancer death worldwide. astragalus polysaccharide (aps), the primary active component extracted from a traditional chinese medicinal herb astragalus membranaceus, has been proved to exert a marked inhibitory effect on a number of types of human solid tumors. in the present study, we aimed to examine the effects of aps on the survival of the hcc cell line h22 and to elucidate the underlying regulatory mechanisms responsible for th ... | 2016 | 27279598 |
| enhancing growth and non-specific immunity of grass carp and nile tilapia by incorporating chinese herbs (astragalus membranaceus and lycium barbarum) into food waste based pellets. | the effects of astragalus membranaceus and lycium barbarum on the growth performance and non-specific immunity of grass carp and nile tilapia were studied. herb extracts of chinese medicinal herbs (2 g kg(-1) or 20 g kg(-1)) were incorporated into food waste based fish feed pellets. fish growth and selected non-specific immune parameters of grass carp and nile tilapia were studied in two separate feeding trials. both grass carp and nile tilapia fed diets of feed pellets containing 2 g kg(-1)lyci ... | 2016 | 27241744 |
| the effects of astragalus membranaceus on oxygen consumption in the intestine. | to investigate the effects of astragalus membranaceus (am) on intestinal oxygen consumption both in vivo and in vitro. | 1997 | 27239146 |
| characterization of the physiological response following in vivo administration of astragalus membranaceus. | the botanical, astragalus membranaceus, is a therapeutic in traditional chinese medicine. limited literature exists on the overall in vivo effects of a. membranaceus on the human body. this study evaluates the physiological responses to a. membranaceus by measuring leukocyte, platelet, and cytokine responses as well as body temperature and blood pressure in healthy individuals after the in vivo administration of a. membranaceus. a dose-dependent increase in monocytes, neutrophils, and lymphocyte ... | 2016 | 27190535 |
| [comparison between astragalus membranaceus var. mongholicus and hedysarum polybotrys based on its sequences and metabolomics]. | astragalus membranaceus var. mongholicus and hedysarum polybotrys belong to different genera, but have similar drug efficacy in traditional chinese medicine theory, and h. polybotrys was used as the legal a. membranaceus var. mongholicus previously. in this study, similarities and differences between them were analyzed via their its/its2 fragments information. the its (internal transcribed spacer) regions were amplified using polymerase chain reaction and then sequenced in two-way. the alignment ... | 2015 | 27169287 |
| astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro. | epithelial-mesenchymal transition (emt) induces the progression of renal tubulointerstitial fibrosis. astragalus membranaceus (am) is a traditional chinese herbal medicine that has been demonstrated to exert anti-inflammatory and anti-cancer effects, in addition to protecting and supporting the immune system. the present study investigated the effects of am on renal fibrosis. a mouse model of unilateral ureteral obstruction (uuo) was established and treated with various concentrations of am (100 ... | 2016 | 27168780 |
| feeding glycyrrhiza glabra (liquorice) and astragalus membranaceus (am) alters innate immune and physiological responses in yellow perch (perca flavescens). | the current work assessed the potential immunomodulatory and growth-promoting effects of astragalus membranaceus (am) and glycyrrhiza glabra (liquorice) in yellow perch (perca flavescens). in this regard, fish with an average weight of 31 ± 1.0 g were divided into five groups, and fed daily with an additive-free basal diet (control); 1, 2, and 3% (w/w) glycyrrhiza glabra, and the fifth diet was incorporated with a combination of 1% g. glabra-am for a four-week period. immunological, biochemical ... | 2016 | 27129627 |
| astragaloside iv prevents high glucose-induced podocyte apoptosis via downregulation of trpc6. | diabetic nephropathy (dn) is one of the most important causes of end‑stage renal disease. astragaloside iv (as-iv) is a saponin isolated from astragalus membranaceus, which possesses various pharmacological activities. as‑iv prevents podocyte apoptosis and ameliorates renal injury in dn; however, few studies have focused on its effects on ion channels. the transient receptor potential channel 6 (trpc6) is an important ca2+‑permeable ion channel in podocytes, which is involved in high glucose (hg ... | 2016 | 27109610 |
| astragalus saponins inhibits lipopolysaccharide-induced inflammation in mouse macrophages. | excessive nitric oxide (no) and pro-inflammatory cytokines are produced during the pathogenesis of inflammatory diseases and cancer. it has been demonstrated that anti-inflammation contributes astragalus membranaceus saponins (ast)'s beneficial effects in combination of conventional anticancer drugs. however, the immunomodulating property of ast has not been well characterized. in this study, we found that ast suppressed lipopolysaccharide (lps)-induced generation of no without causing cytotoxic ... | 2016 | 27109155 |
| structural characterization of low molecular weight polysaccharide from astragalus membranaceus and its immunologic enhancement in recombinant protein vaccine against systemic candidiasis. | structure and immunologic enhancement of low molecular weight polysaccharide (lmw-asp) isolated from the root of astragalus membranaceus (fisch) bge. were detected in recombinant protein vaccine. structure analysis of lmw-asp revealed that lmw-asp (mw=5.6kda) was an acid heteropolysaccharide, which consisted of glc, gal, ara, xyl and gala in ratio of 10.0：1.3：1.7：1.0：0.9. recombinant protein (rp-hsp90c) contained epitope c (lkvirk) from heat shock protein 90 (hsp90) of candida albicans was used ... | 2016 | 27106150 |
| sh003 represses tumor angiogenesis by blocking vegf binding to vegfr2. | tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. here, we demonstrate that sh003, a mixed herbal extract containing astragalus membranaceus (am), angelica gigas (ag) and trichosanthes kirilowii maximowicz (tk), represses vegf-induced tumor angiogenesis both in vitro and in vivo. sh003 inhibited vegf-induced migration, invasion and tube formation in human umbilical vein endothelial cells (huvec) with no effect on the prolif ... | 2016 | 27105528 |
| an aptamer based lateral flow strip for on-site rapid detection of ochratoxin a in astragalus membranaceus. | an aptamer based lateral flow strip based on competitive format was developed for on-site rapid detection of ochratoxin a (ota) in astragalus membranaceus. some crucial parameters that might influence the sensitive detection, such as the characterization of the colloidal gold, size and shape of gold nanoparticles (aunps), amount of aunps-aptamer conjugate, migration rate and the addition amount of methanol, were investigated to provide the optimum assay performance. to perform the test, 1g sampl ... | 2016 | 27085019 |
| astragaloside iv facilitates glucose transport in c2c12 myotubes through the irs1/akt pathway and suppresses the palmitate-induced activation of the ikk/iκbα pathway. | astragaloside iv is a monomer isolated from astragalus membranaceus (fisch.) bunge, which is one of the most widely used plant-derived drugs in traditional chinese medicine for diabetes therapy. in the present study, we aimed to examine the effects of astragaloside iv on glucose in c2c12 myotubes and the underlying molecular mechanisms responsible for these effects. four-day differentiated c2c12 myotubes were exposed to palmitate for 16 h in order to establish a model of insulin resistance and 3 ... | 2016 | 27082050 |
| distinguishing astragalus mongholicus and its planting soil samples from different regions by icp-aes. | "daodi herb" enjoys a good reputation for its quality and clinical effects. as one of the most popular daodi herbs, astragalus membranaceus (fisch.) bge var. mongholicus (bge.) hsiao (a. membranaceus) is popularly used for its anti-oxidant, anti-inflammatory and immune-enhancing properties. in this study, we used inductively coupled plasma atomic emission spectrometry (icp-aes) technique to investigate the inorganic elements contents in a. mongholicu and its soil samples from daodi area (shanxi) ... | 2016 | 27077837 |
| astragaloside iv protects cardiomyocytes from anoxia/reoxygenation injury by upregulating the expression of hes1 protein. | astragaloside iv (asi), a traditional chinese medicine, is a main active ingredient of astragalus membranaceus. many clinical studies have found that asi protects cardiomyocytes in cardiovascular diseases, but the underlying mechanisms remain obscure. the aim of this study was to investigate the molecular mechanisms responsible for the protective effects of asi in cardiomyocytes from anoxia/reoxygenation (a/r) injury. according to the previous studies, we hypothesized that the cardioprotective e ... | 2016 | 27070866 |
| effect of dangguibohyul-tang, a mixed extract of astragalus membranaceus and angelica sinensis, on allergic and inflammatory skin reaction compared with single extracts of astragalus membranaceus or angelica sinensis. | dangguibohyul-tang (dbt), herbal formula composed of astragalus membranaceus (am) and angelica sinensis (as) at a ratio of 5 : 1, has been used for the treatment of various skin diseases in traditional medicine. we investigated the effect of dbt on allergic and inflammatory skin reaction in atopic dermatitis-like model compared to the single extract of am or as. dbt treatment showed the remission of clinical symptoms, including decreased skin thickness and scratching behavior, the total serum ig ... | 2016 | 27051450 |
| aromatic constituents from the stems of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. | four new aromatic constituents, astraflavonoids a (1), b (2), c (3), and astramemoside a (4), along with sixteen known ones 5-20 were obtained from the stems of a. membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. their structures were elucidated by chemical and spectroscopic methods. among the known isolates, 14 was obtained from the astragalus genus for the first time, while 7-12, 18-20 were isolated from the species for the first time. the effects of the compounds obtained from the pl ... | 2016 | 26999087 |
| an evaluation of root phytochemicals derived from althea officinalis (marshmallow) and astragalus membranaceus as potential natural components of uv protecting dermatological formulations. | as lifetime exposure to ultraviolet (uv) radiation has risen, the deleterious effects have also become more apparent. numerous sunscreen and skincare products have therefore been developed to help reduce the occurrence of sunburn, photoageing, and skin carcinogenesis. this has stimulated research into identifying new natural sources of effective skin protecting compounds. alkaline single-cell gel electrophoresis (comet assay) was employed to assess aqueous extracts derived from soil or hydroponi ... | 2016 | 26953144 |
| integrating transcriptomics and metabolomics to characterise the response of astragalus membranaceus bge. var. mongolicus (bge.) to progressive drought stress. | astragalus membranaceus bge. var. mongolicus (bge.) hsiao (a. mongolicus) is an important traditional chinese herb that is cultivated on a large scale in northwestern china. understanding plant responses to drought has important effects on ecological environment recovery and local economic development. here, we combined transcriptomics (illumina hiseq 2000) and metabolomics ((1)h-nmr) to investigate how the roots of two-year-old a. mongolicus responded to 14 days of progressive drought stress. | 2016 | 26944555 |
| astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. | astragalus membranaceus is a major medicinal herb commonly used in many herbal formulations in the practice of traditional chinese medicine (tcm) to treat a wide variety of diseases and body disorders. among its diversified clinical applications, the potential use of this herb and its chemical constituents in treatments of inflammatory diseases and cancers has been actively investigated in recent years. astragalus-based treatments have demonstrated significant amelioration of the toxicity induce ... | 2016 | 26916911 |
| genetic diversity and distribution of rhizobia associated with the medicinal legumes astragalus spp. and hedysarum polybotrys in agricultural soils. | with the increasing cultivation of medicinal legumes in agricultural fields, the rhizobia associated with these plants are facing new stresses, mainly from fertilization and irrigation. in this study, investigations on the nodulation of three cultivated medicinal legumes, astragalus mongholicus, astragalus membranaceus and hedysarum polybotrys were performed. bacterial isolates from root nodules of these legumes were subjected to genetic diversity and multilocus sequence analyses. in addition, t ... | 2016 | 26915496 |
| integrative medicine for relief of nausea and vomiting in the treatment of colorectal cancer using oxaliplatin-based chemotherapy: a systematic review and meta-analysis. | the management of chemotherapy-induced nausea and vomiting (cinv) remains an issue in the treatment of colorectal cancer using oxaliplatin-based regimens. certain traditional plant-based medicines (tms) have histories of use for nausea and vomiting and have been integrated with conventional therapies for cinv. to assess the effectiveness of integrative management of cinv, meta-analysis was conducted of 27 randomised controlled studies (1843 participants) published from 2005 to 2013. the oxalipla ... | 2016 | 26912094 |
| intraspecific and heteroplasmic variations, gene losses and inversions in the chloroplast genome of astragalus membranaceus. | astragalus membranaceus is an important medicinal plant in asia. several of its varieties have been used interchangeably as raw materials for commercial production. high resolution genetic markers are in urgent need to distinguish these varieties. here, we sequenced and analyzed the chloroplast genome of a. membranaceus (fisch.) bunge var. mongholicus (bunge) p.k. hsiao using the next generation dna sequencing technology. the genome was assembled using abyss and then subjected to gene prediction ... | 2016 | 26899134 |
| bioactive cyclolanstane-type saponins from the stems of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. | twelve cyclolanstane-type saponins including six new ones, astrolanosaponins a1 (1), a2 (2), b (3), c (4), d (5), and e (6) were obtained from the stem of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, and their structures were elucidated by chemical and spectroscopic methods. of the known ones, cycloastragenol-3-o-β-d-glucopyranoside (7), astraverrucin ii (8), cycloaraloside e (9), huangqiyenin a (10), and huangqiyenin b (11) were isolated from the species first. meanwhile ... | 2016 | 26800699 |
| comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system. | in this study, polysaccharides were isolated from astragalus membranaceus, ganoderma lucidum and radix ophiopogonis and named apsii, glpii and ogpii for comparison of their immunoactivities. mtt assay indicated that these polysaccharides increased the metabolic activity of raw264.7 macrophages and induced cell differentiation to dendritic like cells. high content screening and mathematical modeling were used to quantify the cell irregularity, a hallmark of cell differentiation by polysaccharides ... | 2016 | 26783639 |
| [effects of couplet medicines (astragalus membranaceus and jiaozhen) on intestinal barrier in postoperative colorectal cancer patients]. | to observe the effect of the couplet medicines (astragalus membranaceus and jiaozhen) on intestinal barrier functions of postoperative colorectal cancer patients. | 2015 | 26775475 |
| tlr-4 may mediate signaling pathways of astragalus polysaccharide rap induced cytokine expression of raw264.7 cells. | polysaccharides of radix astragali (astragalus membranaceus (fisch) bge.; huangqi) are able to induce cytokine production of macrophages and are considered the main active ingredient for the immune-enhancing effect of this commonly used medicinal herb. | 2016 | 26743224 |
| astragalus membranaceus (am) enhances growth performance and antioxidant stress profiles in bluegill sunfish (lepomis macrochirus). | this study was designed to assess the potential effects of astragalus membranaceus (am) on the growth performance and antioxidative stress response in bluegill sunfish (lepomis macrochirus) exposed to challenging cold water temperature conditions. in this regard, fish with an average weight of 43 ± 1 g were divided into four groups and fed daily with an am-free diet (control), and 1.5, 3, and 4.5 % (w/w) am-incorporated diets for an 8-week period. oxidative stress response, biochemical, and grow ... | 2016 | 26729192 |
| protection against oxidative stress-induced apoptosis in kidney epithelium by angelica and astragalus. | astragalus membranaceus either alone or in combination with angelica sinensis has been used traditionally for kidney disease in east asia and china for thousands of years. previous studies using in vivo animal models have shown the benefits of these medicinal herbs in kidney diseases that involve oxidative stress. however, the mechanisms by which these medicinal herbs protect kidney cells remain largely unknown. | 2016 | 26719285 |
| an in vivo molecular response analysis of colorectal cancer treated with astragalus membranaceus extract. | the fact that many chemotherapeutic drugs cause chemoresistance and side effects during the course of colorectal cancer treatment necessitates development of novel cytotoxic agents aiming to attenuate new molecular targets. here, we show that astragalus membranaceus (fischer) bge. var. mongolicus (bge.) hsiao (am), a traditional chinese medicine, can inhibit tumor growth in vivo and elucidate the underlying molecular mechanisms. the antitumor effect of am was assessed on the subcutaneous tumors ... | 2016 | 26719057 |
| a combination of the main constituents of fufang xueshuantong capsules shows protective effects against streptozotocin-induced retinal lesions in rats. | fufang xueshuantong capsule, an herbal formula licensed for clinical use in china, which is composed of panax notoginseng (burkill) f.h. chen, salvia miltiorrhiza bunge, astragalus membranaceus (fisch.) bunge, and scrophularia ningpoensis hemsl, has proven effective for the treatment of diabetic retinopathy. however, its bioactive constituents are still ambiguous. in this study, the therapeutic effects of a combination of the main constituents of fufang xueshuantong capsule (cfxt) were evaluated ... | 2016 | 26692279 |
| oleanane type saponins from the stems of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. | astragalus membranaceus is a traditional chinese medicine (tcm) belonging to the leguminosae family. it has been used as antidiabetic, cardioprotective, and hepatoprotective in the tcm clinic. from the stems of a. membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins a (1), b (2), c1 (3), c2 (4), d (5), e1 (6), e2 (7), and f (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods ... | 2016 | 26687558 |
| [formula optimization in renshen jianxin capsule based on uniform design and anti-myocardial ischemia effect]. | to realize quadratic formula optimization of renshen jianxin capsule (rjc) by screening chinese herbs with major anti-myocardial ischemia effect in rjc and optimize their optimal dosages. | 2015 | 26591367 |
| qishenyiqi dropping pill attenuates myocardial fibrosis in rats by inhibiting raas-mediated arachidonic acid inflammation. | in china, qishenyiqi dropping pill (qsdp), a chinese medicine formula containing astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, panax notoginseng (burkill) f.h.chen and dalbergia odorifera t.c.chen, has been used frequently in traditional folk medicine for treatment of coronary heart diseases (chd) and heart failure (hf). | 2015 | 26590099 |
| calycosin-7-o-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the bmp/wnt signaling pathways. | the isoflavone calycosin-7-o-β-d-glucopyranoside (cg) is a principal constituent of astragalus membranaceus (ar) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. the aim of this study was to investigate the osteogenic effects of cg and its underlying mechanism in st2 cells. the results show that exposure of cells to cg in osteogenic differentiation medium increases alp activity, osteocalcin (ocal) mrna expression and the osteoblastic mineralization process. ... | 2015 | 26579475 |
| structural characterization of an intestinal immune system-modulating arabino-3,6-galactan-like polysaccharide from the above-ground part of astragalus membranaceus (bunge). | arabino-3,6-galactan (ama-1-b-ps2), an intestinal immunomodulatory compound, was purified from the above-ground portion of astragalus membranaceus (bunge). its structure was characterized using sequential enzymatic digestion with exo-α-l-arabinofuranosidase (afase) and exo-β-d-(1 → 3)-galactanase (gnase), producing small amounts of intermediate-sized and shorter oligosaccharide (af-ps2-g2 and af-ps2-g3) fractions, and a large gnase-resistant fraction (af-ps2-g1). simultaneous afase and gnase dig ... | 2016 | 26572470 |
| advances on bioactive polysaccharides from medicinal plants. | in recent decades, the polysaccharides from the medicinal plants have attracted a lot of attention due to their significant bioactivities, such as anti-tumor activity, antioxidant activity, anticoagulant activity, antidiabetic activity, radioprotection effect, anti-viral activity, hypolipidemic and immunomodulatory activities, which make them suitable for medicinal applications. previous studies have also shown that medicinal plant polysaccharides are non-toxic and show no side effects. based on ... | 2016 | 26463231 |
| triterpenoids and flavonoids from the leaves of astragalus membranaceus and their inhibitory effects on nitric oxide production. | four new cycloartane triterpenes, named huangqiyegenins v and vi and huangqiyenins k and l (1-4, resp.), together with nine known triterpenoids, 5-13, and eight flavonoids, 14-21, were isolated from a 70%-etoh extract of astragalus membranaceus leaves. the structures of the new compounds were elucidated by detailed spectroscopic analyses, and the compounds were identified as (9β,11α,16β,20r,24s)-11,16,25-trihydroxy-20,24-epoxy-9,19-cyclolanostane-3,6-dione (1), (9β,16β,24s)-16,24,25-trihydroxy-9 ... | 2015 | 26460562 |
| effects of astragalus membranaceus-based chinese medicine formulae on residual renal function in patients on peritoneal dialysis. | 2015 | 26450483 | |
| characterization and comparison of polysaccharides from lycium barbarum in china using saccharide mapping based on pace and hptlc. | water-soluble polysaccharides from 51 batches of fruits of l. barbarum (wolfberry) in china were investigated and compared using saccharide mapping, partial acid hydrolysis, single and composite enzymatic digestion, followed by polysaccharide analysis by using carbohydrate gel electrophoresis (pace) analysis and high performance thin layer chromatography (hptlc) analysis, respectively. results showed that multiple pace and hptlc fingerprints of partial acid and enzymatic hydrolysates of polysacc ... | 2015 | 26428094 |
| triterpene and flavonoid biosynthesis and metabolic profiling of hairy roots, adventitious roots, and seedling roots of astragalus membranaceus. | astragalus membranaceus is an important traditional chinese herb with various medical applications. astragalosides (asts), calycosin, and calycosin-7-o-β-d-glucoside (cg) are the primary metabolic components in a. membranaceus roots. the dried roots of a. membranaceus have various medicinal properties. the present study aimed to investigate the expression levels of genes related to the biosynthetic pathways of asts, calycosin, and cg to investigate the differences between seedling roots (srs), a ... | 2015 | 26402168 |
| beneficial effects of astragaloside iv against angiotensin ii-induced mitochondrial dysfunction in rat vascular smooth muscle cells. | angiotensin ii (ang ii)-induced mitochondrial dysfunction is a prominent characteristic of the majority of cardiovascular diseases. astragaloside iv (as-iv), the major active ingredient of astragalus membranaceus (fisch.) bge. (a traditional chinese herbal medicine), possesses antioxidant properties. the present study was carried out to examine whether as-iv can reverse ang ii-induced mitochondrial dysfunction in vascular smooth muscle cells (vsmcs) and to elucidate the underlying molecular mech ... | 2015 | 26398547 |
| protective effect of astragaloside iv on lipopolysaccharide-induced cardiac dysfunction via downregulation of inflammatory signaling in mice. | astragaloside iv (asi) is a major and active saponin derivative of astragalus membranaceus (fisch) bge. the anti-inflammatory properties of asi are important for its cardioprotective effects. however, the molecular mechanisms of the protective effect of asi on lipopolysaccharide (lps)-induced cardiac dysfunction is yet to be elucidated. | 2015 | 26376109 |
| ultraviolet radiation-elicited enhancement of isoflavonoid accumulation, biosynthetic gene expression, and antioxidant activity in astragalus membranaceus hairy root cultures. | in this work, astragalus membranaceus hairy root cultures (amhrcs) were exposed to ultraviolet radiation (uv-a, uv-b, and uv-c) for promoting isoflavonoid accumulation. the optimum enhancement for isoflavonoid production was achieved in 34-day-old amhrcs elicited by 86.4 kj/m(2) of uv-b. the resulting isoflavonoid yield was 533.54 ± 13.61 μg/g dry weight (dw), which was 2.29-fold higher relative to control (232.93 ± 3.08 μg/g dw). uv-b up-regulated the transcriptional expressions of all investig ... | 2015 | 26370303 |
| structural characterization and evaluation of the antioxidant activity of phenolic compounds from astragalus taipaishanensis and their structure-activity relationship. | eight phenolic compounds were isolated using bio-guided isolation and purified from the roots of astragalus taipaishanensis y. c. ho et s. b. ho (a. taipaishanensis) for the first time. their structures were elucidated by esi-ms, hr-esi-ms, 1d-nmr and 2d-nmr as 7,2'-dihydroxy-3',4'-dimethoxy isoflavan (1), formononetin (2), isoliquiritigenin (3), quercetin (4), kaempferol (5), ononin (6), p-hydroxybenzoic acid (7) and vanillic acid (8). six flavonoids (compounds 1-6) exhibited stronger antioxida ... | 2015 | 26350974 |
| calycosin-7-o-β-d-glucoside promotes oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells. | dysfunction of vascular endothelium is implicated in many pathological situations. cytoskeleton plays an importance role in vascular endothelial permeability barrier and inflammatory response. many chinese herbs have the endothelial protective effect, of which, "astragalus membranaceus" is a highly valued herb for treatment of cardiovascular and renal diseases in traditional chinese medicine, in this study, we tested whether calycosin-7-o-β-d-glucoside (calycosin), a main effective monomer compo ... | 2015 | 26346982 |
| the antioxidant effects of radix astragali (astragalus membranaceus and related species) in protecting tissues from injury and disease. | oxidative stress plays a key role in the pathogenesis of various diseases. antioxidants protect the cells and tissues from oxidative stress by scavenging free radicals and reactive oxygen species. these antioxidants may be endogenous or exogenous. plants are considered as potential and powerful exogenous source of antioxidants. astragalus species (spp.), especially astragalus membranaceus, have a long history of medicinal use in traditional chinese medicine. specifically, constituents of the dri ... | 2016 | 26343107 |
| formononetin sensitizes glioma cells to doxorubicin through preventing emt via inhibition of histone deacetylase 5. | chemoresistance is a major obstacle to successful chemotherapy for glioma. formononetin is a novel herbal isoflavonoid isolated from astragalus membranaceus and possesses antitumorigenic properties. in the present study, we investigated the anti-proliferative effects of formononetin on human glioma cells, and further elucidated the molecular mechanism underlying the anti-tumor property. we found that formononetin enhanced doxorubicin cytotoxicity in glioma cells. combined treatment with formonon ... | 2015 | 26261519 |
| effects of treatment with astragalus membranaceus on function of rat leydig cells. | astragalus membranaceus (am) is a chinese traditional herb which has been reported to have broad positive effects on many diseases, including hepatitis, heart disease, diabetes and skin disease. am can promote cell proliferation, increase the activities of superoxide dismutase (sod) and glutathione peroxidase (gpx), and inhibit apoptosis by regulating the transcription of proto-oncogenes controlling cell death. while am is included in some commercially available "testosterone boosting supplement ... | 2015 | 26231491 |
| astragaloside iv suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the mapk and nf-κb signaling pathways. | renal fibrosis, a progressive process characterized by the accumulation of extracellular matrix (ecm) leading to organ dysfunction, is a characteristic of chronic kidney diseases. among fibrogenic factors known to regulate the renal fibrotic process, transforming growth factor-β (tgf-β) plays a central role. in the present study, we examined the effect of astragaloside iv (as-iv), a component of the traditional chinese medicinal plant astragalus membranaceus, on the processes associated with ren ... | 2015 | 26220342 |
| the antithrombotic effect of rsnk in blood-stasis model rats. | reduction of sheng-nao-kang decoction (rsnk), composed of salvia miltiorrhiza bge., ligusticum chuanxiong hort., astragalus membranaceus (fisch.) bunge., pueraria lobata (willd.) ohwi., paeonia lactiflora pall. and panax notoginseng (burk.) f. h. chen., is a modified traditional chinese medicinal formula of sheng-nao-kang pill preparation, which has been investigated its protective effect on focal cerebral ischemia-reperfusion injury in rat in our previous report. | 2015 | 26216512 |