Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during ndea-induced rat hepatocarcinogenesis. | dieckol (dek) is a major polyphenol of marine brown seaweed ecklonia cava which is a potential candidate for cancer therapy. however, the underlying mechanism of dek as an anticancer drug remains to be elucidated. in this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of dek in n-nitrosodiethylamine (ndea)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (xmes), apoptosis, invasion, and angiogenesis. rats administere ... | 2017 | 28397013 |
| the effect of phloroglucinol, a component of ecklonia cava extract, on hepatic glucose production. | phloroglucinol is a phenolic compound that is one of the major compounds in ecklonia cava (brown alga). it has many pharmacological activities, but its anti-diabetic effect is not yet fully explored. in this study, we investigated the effect of phloroglucinol on the control of blood glucose levels and the regulation of hepatic glucose production. phloroglucinol significantly improved glucose tolerance in male c57bl/6j mice fed a high fat diet (hfd) and inhibited glucose production in mouse prima ... | 2017 | 28379184 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28350055 |
| antimicrobial, antioxidant, and anticancer activities of biosynthesized silver nanoparticles using marine algae ecklonia cava. | green synthesis of silver nanoparticles (agnps) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. in this study, agnps were synthesized by using extracts of marine algae ecklonia cava as reducing and capping agents. the formation of agnps using aqueous extract of ecklonia cava was confirmed visually by color change and their surface plasmon resonance peak at 418 nm, measured by uv-visible spectroscopy. the size, shape, and morphology of the bios ... | 2016 | 28335363 |
| a phlorotannin constituent of ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | 2,7″-phloroglucinol-6,6'-bieckol is a type of phlorotannin isolated from brown algae, ecklonia cava kjellman (phaeophyceae; laminareaceae). 2,7″-phloroglucinol-6,6'-bieckol mediates antioxidant activities. however, there has been no research on improving postprandial hyperglycaemia using 2,7″-phloroglucinol-6,6'-bieckol. | 2017 | 28219252 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28204815 |
| protective effects of dieckol on n-nitrosodiethylamine induced hepatocarcinogenesis in rats. | dieckol (dek) is a naturally occuring phlorotannins found in marine brown algae ecklonia cava which is attributed with various pharmacological properties. this study was aimed to investigate the protective role of dek on n-nitrosdiethylamine (ndea) induced rat hepatocarcinogenesis. in this investigation 0.01% ndea in drinking water for 15 weeks to induce hepatocellular carcinoma (hcc). dek was administered orally (10, 20 and 40mg/kg body weight) for 15 weeks with 0.01% ndea through drinking wate ... | 2016 | 27825803 |
| dioxinodehydroeckol enhances the differentiation of osteoblasts by regulating the expression of phospho-smad1/5/8. | lack of bone formation-related health problems are a major problem for the aging population in the modern world. as a part of the ongoing trend of developing natural substances that attenuate osteoporotic bone loss conditions, dioxinodehydroeckol (dhe) from edible brown alga ecklonia cava was tested for its effects on osteoblastogenic differentiation in mc3t3-e1 pre-osteoblasts. dhe was observed to successfully enhance osteoblast differentiation, as indicated by elevated cell proliferation, alka ... | 2016 | 27649211 |
| enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich ecklonia cava extract seanol(®) to endow antibacterial properties and promote mineralization. | hydrogels offer several advantages as biomaterials for bone regeneration, including ease of incorporation of soluble substances such as mineralization-promoting enzymes and antibacterial agents. mineralization with calcium phosphate (cap) increases bioactivity, while antibacterial activity reduces the risk of infection. here, gellan gum (gg) hydrogels were enriched with alkaline phosphatase (alp) and/or seanol(®), a seaweed extract rich in phlorotannins (brown algae-derived polyphenols), to indu ... | 2016 | 27509486 |
| protective effect of a purified polyphenolic extract from ecklonia cava against noise-induced hearing loss: prevention of temporary threshold shift. | noise is one of the most common causes of hearing loss. approximately 16% of american teenagers (12-19 years) have hearing loss caused by loud noise. the implication of noise-induced hearing loss (nihl) in teenagers has received increasing attention. although temporary threshold shift (tts), a type of nihl, is a transient hearing loss, it can accelerate age-related hearing loss. reactive oxygen species are a primary cause of tts. as the polyphenols from ecklonia cava are known to have potent ant ... | 2016 | 27368468 |
| microrna134 mediated upregulation of jnk and downregulation of nfkb signalings are critically involved in dieckol induced antihepatic fibrosis. | though dieckol, a phlorotannin of ecklonia cava, was known to have antioxidant, anticancer, antidiabetic, and anti-inflammatory effects, the underlying antifibrotic mechanism of dieckol still remains unclear until now. thus, in the current study, the inhibitory mechanism of dieckol on liver fibrosis was elucidated mainly in hepatic stellate cells (hscs). dieckol exerted cytotoxicity in lx-2, hsc-t6, and hepg2 cells with the reduced fibrosis features of large, spread out, and flattened polygonal ... | 2016 | 27321552 |
| a prebiotic role of ecklonia cava improves the mortality of edwardsiella tarda-infected zebrafish models via regulating the growth of lactic acid bacteria and pathogen bacteria. | in this study, the beneficial prebiotic roles of ecklonia cava (e. cava, ec) were evaluated on the growth of lactic acid bacteria (lab) and pathogen bacteria and the mortality of pathogen-bacteria infected zebrafish model. the result showed that the original e. cava (ec) led to the highest growth effects on three labs (lactobacillus brevis, l. brevis; lactobacillus pentosus, l. pentosus; lactobacillus plantarum; l. plantarum) and it was dose-dependent manners. also, ec, its celluclast enzymatic ... | 2016 | 27192145 |
| effects of ecklonia cava as fucoidan-rich algae on growth performance, nutrient digestibility, intestinal morphology and caecal microflora in weanling pigs. | in the present study, role of increasing levels of ecklonia cava (seaweed) supplementation in diets was investigated on growth performance, coefficient of total tract apparent digestibility (cttad) of nutrients, serum immunoglobulins, cecal microflora and intestinal morphology of weanling pigs. | 2017 | 27165019 |
| seaweed extracts as a potential tool for the attenuation of oxidative damage in obesity-related pathologies(1). | recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. the exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity-related pathologies. the objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ros) production during the adipogenesis ... | 2011 | 27021984 |
| a molecular investigation of the genus ecklonia (phaeophyceae, laminariales) with special focus on the southern hemisphere. | brown algae of the order laminariales, commonly referred to as kelps, are the largest and most productive primary producers in the coastal inshore environment. the genus ecklonia (lessoniaceae, phaeophyceae) consists of seven species with four species in the northern hemisphere and three in the southern hemisphere. it was recently transferred to the family lessoniaceae based on phylogenetic analyses of nuclear and chloroplastic markers, though the type of the genus was not included and its relat ... | 2015 | 26986519 |
| a prebiotic effect of ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria. | olive flounder (paralichthys olivaceus), also known as the japanese flounder in japan, is one of the most important commercial marine finfish species cultured in korea and japan. the purpose of this study was to evaluate how a species of brown algae (ecklonia cava, e. cava) affects the growth rate of olive flounder and its immune response to pathogenic bacteria. first, the experimental fish were divided into four groups: the control group was fed the diet containing only 1.0% lactobacillus plant ... | 2016 | 26921543 |
| enhancement of human hair growth using ecklonia cava polyphenols. | ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. e. cava polyphenols (ecps) are known to increase fibroblast survival. the human dermal papilla cell (hdpc) has the properties of mesenchymal-origin fibroblasts. | 2016 | 26848214 |
| protective effect of brown alga phlorotannins against hyper-inflammatory responses in lipopolysaccharide-induced sepsis models. | brown algae have been recognized as a food ingredient and health food supplement in japan and korea, and phlorotannins are unique marine phenol compounds produced exclusively by brown algae. sepsis is a whole-body inflammatory condition with a mortality rate of 30-40%. here, we investigated the effects of a phlorotannin-rich extract of the edible brown alga ecklonia cava against hyper-inflammatory response in lps-induced septic shock mouse model. e. cava extract significantly increased the survi ... | 2016 | 26730445 |
| seapolynol extracted from ecklonia cava inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. | seapolynol (sn) is a polyphenol mixture derived from ecklonia cava. we evaluated the effects of sn on lipid accumulation in adipocytes, zebrafish, and mice. sn effectively inhibited lipid accumulation in three experimental models by suppressing adipogenic factors. triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (dgat1) and gpat3 were also downregulated by sn. this sn-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of sn on early adipo ... | 2015 | 26690099 |
| polyphenol-rich fraction of ecklonia cava improves nonalcoholic fatty liver disease in high fat diet-fed mice. | ecklonia cava (e. cava; ca) is an edible brown alga with beneficial effects in diabetes via regulation of various metabolic processes such as lipogenesis, lipolysis, inflammation, and the antioxidant defense system in liver and adipose tissue. we investigated the effect of the polyphenol-rich fraction of e. cava produced from gijang (g-ca) on nonalcoholic fatty liver disease (nafld) in high-fat diet (hfd)-fed mice. c57bl6 mice were fed a hfd for six weeks and then the hfd group was administered ... | 2015 | 26569269 |
| dioxinodehydroeckol protects human keratinocyte cells from uvb-induced apoptosis modulated by related genes bax/bcl-2 and caspase pathway. | although ultraviolet b (uvb) has a low level of skin penetration, it readily results in epidermal sunburn of keratinocytes that are destined to apoptosis after sun expose, and leads to dna damage. dioxinodehydroeckol (dhe), a phlorotannin from ecklonia cava has been explored for its preventive activity against uvb-induced apoptosis in human keratinocyte (hacat) cells; however, the protective effects of treatment with low doses of dhe on uvb-damaged cells post-uvb exposure and their underlying me ... | 2015 | 26529485 |
| flavobacterium jejuensis sp. nov., isolated from marine brown alga ecklonia cava. | a bacterial strain, designated ec11(t) was isolated from brown alga ecklonia cava collected from jeju island, korea. ec11(t) was identified as a gram-negative, rod-shaped and yellow-pigmented bacterial strain. the strain ec11(t) grew over a temperature range of 10 °c to 30 °c (optimally at 25 °c), and a ph range of 6.0-10.5 (optimally at ph 7.5). phylogenetic analysis based on 16s rrna gene sequences showed that strain ec11(t) belongs to the genus flavobacterium. strain ec11(t) shared close simi ... | 2015 | 26502959 |
| the cytoprotective effects of ethanol extract of ecklonia cava against oxidative stress are associated with upregulation of nrf2-mediated ho-1 and nqo-1 expression through activation of the mapk pathway. | the aim of the present study was to examine the cytoprotective effect of ecklonia cava against oxidative stress in c2c12 myoblasts. the ethanol extract of e. cava (eeec) prevented hydrogen peroxide (h₂o₂)-induced inhibition of the growth of c2c12 myoblasts and exhibited scavenging activity against intracellular reactive oxygen species (ros) induced by h₂o₂. eeec treatment attenuated h2o2-induced comet tail formation and phospho-histone γh2a.x expression. furthermore, eeec treatment enhanced the ... | 2016 | 26492067 |
| evaluation of effective mmp inhibitors from eight different brown algae in human fibrosarcoma ht1080 cells. | matrix metalloproteinases (mmps) are crucial extracellular matrices degrading enzymes that have important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. marine plants are on the rise for their potential to provide natural products that exhibit remarkable health benefits. in this context, brown algae species have been of much interest in the pharmaceutical field with reported instances of isolation of bioactive comp ... | 2015 | 26451351 |
| the anti-aging properties of a human placental hydrolysate combined with dieckol isolated from ecklonia cava. | in the present study, we aimed to examine the anti-aging properties of human placental hydrolysate (hpe) and dieckol (de) from ecklonia cava against free radical scavenging, muscle hypertrophy-related follistatin mrna expression, amelioration of cognition-related genes and proteins, inhibition of collagenase-regulating genes, and elastinase activity. | 2015 | 26438076 |
| a sulfated polysaccharide of ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. | we investigated anticancer effects of the crude polysaccharides (cps) isolated from ecklonia cava enzymatic extracts using amg, viscozyme, protamex, and alcalase enzyme against a colon cancer cell line, ct26 cells. among them, the cp of protamex extract (pcp) contained the highest fucose and sulfated group contents and showed the highest growth inhibitory effect against ct-26 cells. in addition, pcp dose-dependently increased the formation of apoptotic body and the percentage of sub-g1 dna conte ... | 2015 | 26417363 |
| 6,6'-bieckol protects insulinoma cells against high glucose-induced glucotoxicity by reducing oxidative stress and apoptosis. | pancreatic β cells are highly sensitive to oxidative stress, which might play an important role in β cell death in diabetes. the protective effect of 6,6'-bieckol, a phlorotannin polyphenol compound purified from ecklonia cava, against high glucose-induced glucotoxicity was investigated in rat insulinoma cells. high glucose (30 mm) treatment induced the death of rat insulinoma cells, but treatment with 10 or 50 μg/ml 6,6'-bieckol significantly inhibited the high glucose-induced glucotoxicity. fu ... | 2015 | 26343533 |
| phloroglucinol attenuates the cognitive deficits of the 5xfad mouse model of alzheimer's disease. | alzheimer's disease (ad) is the most common form of dementia among the elderly. neuritic plaques whose primary component is amyloid beta peptide (aβ) and neurofibrillary tangles which are composed of hyperphosphorylated tau, are known to be the neuropathological hallmarks of ad. in addition, impaired synaptic plasticity in neuronal networks is thought to be important mechanism underlying for the cognitive deficits observed in ad. although various causative factors, including excitotoxicity, mito ... | 2015 | 26284625 |
| dieckol, a phlorotannin of ecklonia cava, suppresses ige-mediated mast cell activation and passive cutaneous anaphylactic reaction. | 2015 | 26194398 | |
| ecklonia cava polyphenol has a protective effect against ethanol-induced liver injury in a cyclic amp-dependent manner. | previously, we showed that ecklonia cava polyphenol (ecp) treatment suppressed ethanol-induced increases in hepatocyte death by scavenging intracellular reactive oxygen species (ros) and maintaining intracellular glutathione levels. here, we examined the effects of ecp on the activities of alcohol-metabolizing enzymes and their regulating mechanisms in ethanol-treated hepatocytes. isolated hepatocytes were incubated with or without 100 mm ethanol. ecp was dissolved in dimethylsulfoxide. ecp was ... | 2015 | 26096275 |
| dieckol, a component of ecklonia cava, suppresses the production of mdc/ccl22 via down-regulating stat1 pathway in interferon-γ stimulated hacat human keratinocytes. | macrophage-derived chemokine, c-c motif chemokine 22 (mdc/ccl22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. serum and skin mdc/ccl22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. a major signaling pathway in the interferon-γ (ifn-γ)-stimulated inflammation response involves ... | 2015 | 25995822 |
| winogradskyella eckloniae sp. nov., a marine bacterium isolated from the brown alga ecklonia cava. | a novel bacterial strain, designated ec29(t), was isolated from the brown alga ecklonia cava collected on jeju island, republic of korea. cells of strain ec29(t) were gram-stain-negative, aerobic, rod-shaped and motile by gliding. growth was observed at 10-30 °c (optimum, 20-25 °c), at ph 6.0-9.5 (optimum, ph 7.5) and in the presence of 1-5% (w/v) nacl. phylogenetic analyses based on the 16s rrna gene sequence revealed that the strain belonged to the genus winogradskyella. strain ec29(t) exhibit ... | 2015 | 25979633 |
| dieckol attenuates microglia-mediated neuronal cell death via erk, akt and nadph oxidase-mediated pathways. | excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. thus, the regulation of microglial activation has been evaluated as effective therapeutic strategies. although dieckol (dek), one of the phlorotannins isolated from marine brown alga ecklonia cava, has been previously reported to inhibit microglial activation, the molecu ... | 2015 | 25954126 |
| dieckol, a major phlorotannin in ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: inhibition of early adipogenesis via cell-cycle arrest and ampkα activation. | dieckol is a major polyphenol of ecklonia cava. this study demonstrates a mechanistic role for dieckol in the suppression of lipid accumulation using three models. | 2015 | 25944759 |
| first evidence that ecklonia cava-derived dieckol attenuates mcf-7 human breast carcinoma cell migration. | we investigated the effect of ecklonia cava (e. cava)-derived dieckol on movement behavior and the expression of migration-related genes in mcf-7 human breast cancer cell. phlorotannins (e.g., dieckol, 6,6'-biecko, and 2,7″-phloroglucinol-6,6'-bieckol) were purified from e. cava by using centrifugal partition chromatography. among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. radius™-well was used to assess cell migration, and ... | 2015 | 25830682 |
| phlorofucofuroeckol a isolated from ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | this study was designed to investigate whether phlorofucofuroeckol a inhibited α-glucosidase and α-amylase activities and alleviated postprandial hyperglycemia in diabetic mice. phlorofucofuroeckol a that was isolated from ecklonia cava (brown algae) demonstrated prominent inhibitory effects against α-glucosidase and α-amylase activities. the ic50 values of phlorofucofuroeckol a against α-glucosidase and α-amylase were 19.52 and 6.34μm, respectively. these inhibitory activities of phlorofucofuro ... | 2015 | 25680946 |
| multifunctional activity of polyphenolic compounds associated with a potential for alzheimer's disease therapy from ecklonia cava. | five polyphenols were isolated and purified from a brown alga ecklonia cava. these compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. this led us to investigate the potential of these compounds as alzheimer's disease drugs. all of the compounds showed moderate acetylcholinesterase inhibitory activity in a micromolar range (ic50 from 16.0 to 96.3 μm). for butyrylcholinesterase, a new target for the treatment of alzheimer's dis ... | 2015 | 25640212 |
| projecting the impacts of rising seawater temperatures on the distribution of seaweeds around japan under multiple climate change scenarios. | seaweed beds play a key role in providing essential habitats and energy to coastal areas, with enhancements in productivity and biodiversity and benefits to human societies. however, the spatial extent of seaweed beds around japan has decreased due to coastal reclamation, water quality changes, rising water temperatures, and heavy grazing by herbivores. using monthly mean sea surface temperature (sst) data from 1960 to 2099 and sst-based indices, we quantitatively evaluated the effects of warmin ... | 2015 | 25628878 |
| efficacy and safety of a dieckol-rich extract (ag-dieckol) of brown algae, ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. | the effects of 12 weeks of supplementation with a dieckol-rich extract (ag-dieckol) from brown algae, ecklonia cava, on glycemic parameters, serum biochemistry, and hematology were investigated in this study. eighty pre-diabetic male and female adults were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. subjects were randomly allocated into two groups designated as placebo and ag-dieckol (1500 mg per day). compared with the placebo group, the ag-dieck ... | 2015 | 25608849 |
| dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation. | in the current study it was found that dieckol isolated from edible brown algae, ecklonia cava (ec), as potent anti-proliferative and anti-angiogenic agent. vascular endothelial growth factor (vegf) induced ea.hy926 cell proliferation was suppressed by dieckol treatment. further, it showed a significant inhibition of cell migration via inhibiting the protein and gene expression levels of matrix metalloproteinases, mmp-2 and -9. the signaling cascade underlying these responses was found as the di ... | 2015 | 25531264 |
| brown alga ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of ampk and sirt1 in high-fat diet-induced obese mice. | obesity is considered to be a metaflammatory condition. ecklonia cava, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. this study investigated the effect of e. cava polyphenol extract (ecpe) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. after obesity was induced by a high-fat diet (hfd), the mice were administered ecpe by gavage for 5 days/12 weeks. ecpe supplementation reduced body weig ... | 2015 | 25479240 |
| brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity. | the clinical application of cisplatin is limited due to its drug resistance and side effects. we investigated the effect of a phlorotannin-rich extract from the edible brown alga ecklonia cava (prec) and its major phlorotannin (dieckol) on cisplatin responsiveness and side effects. | 2015 | 25462204 |
| triphlorethol-a from ecklonia cava up-regulates the oxidant sensitive 8-oxoguanine dna glycosylase 1. | this study investigated the protective mechanisms of triphlorethol-a, isolated from ecklonia cava, against oxidative stress-induced dna base damage, especially 8-oxoguanine (8-oxog), in chinese hamster lung fibroblast v79-4 cells. 8-oxoguanine dna glycosylase-1 (ogg1) plays an important role in the removal of 8-oxog during the cellular response to dna base damage. triphlorethol-a significantly decreased the levels of 8-oxog induced by h2o2, and this correlated with increases in ogg1 mrna and ogg ... | 2014 | 25353254 |
| effect of baechu kimchi added ecklonia cava extracts on high glucose-induced oxidative stress in human umbilical vein endothelial cells. | endothelial cell dysfunction is considered to be a major cause of vascular complications in diabetes. in the present study, we investigated the protective effect of a baechu kimchi added ecklonia cava extract (bke) against high glucose induced oxidative damage in human umbilical vein endothelial cells (huvecs). treatment with a high concentration of glucose (30 mm) induced cytotoxicity, whereas treatment with bke protected huvecs from high glucose induced damage; by restoring cell viability. in ... | 2014 | 25320714 |
| 8,8'-bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of nf-κb signaling and ros production in lps-stimulated macrophages. | ecklonia cava (e. cava) is an abundant brown alga that contains high levels of phlorotannins, which are unique marine polyphenolic compounds. it has been suggested that e. cava phlorotannins exert anti-inflammatory effects. however, the anti-inflammatory effects and underlying molecular mechanism exerted by 8,8'-bieckol isolated from e. cava have not been reported. thus, in this study, we examined the anti-inflammatory effects of 8,8'-bieckol on lipopolysaccharide (lps)-stimulated primary macrop ... | 2014 | 25261704 |
| anti-hiv-1 activity of phlorotannin derivative 8,4‴-dieckol from korean brown alga ecklonia cava. | 8,4‴-dieckol is a natural product which has been isolated from brown alga, ecklonia cava. this polyphenolic compound is a phlorotannin derivative with a broad range of bioactivities. its inhibitory activity on human immunodeficiency virus type-1 (hiv-1) was tested and the results indicated that 8,4‴-dieckol inhibited hiv-1 induced syncytia formation, lytic effects, and viral p24 antigen production at noncytotoxic concentrations. furthermore, it was found that 8,4‴-dieckol selectively inhibited t ... | 2014 | 25229850 |
| dieckol, isolated from the edible brown algae ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth. | ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. however, the anticancer effects of dieckol, a major active compound in e. cava, are poorly understood. in the present study, we investigated the anti-tumor activity of dieckol and its molecular mechanism in ovarian cancer cells and in a xenograft mouse model . | 2015 | 25216701 |
| antimetastatic activity of polyphenol-rich extract of ecklonia cava through the inhibition of the akt pathway in a549 human lung cancer cells. | an ethyl acetate extract (ece) of a brown alga, ecklonia cava, was examined for its anti-metastatic effect, using a549 human lung carcinoma cells. ece treatment significantly suppressed the migration and invasion of a549 cells in a concentration-dependent manner. it also strongly down-regulated the matrix metalloproteinase (mmp)-2 activity of the cancer cells by gelatin zymography assay. for elucidating its mechanism of action in cancer cell metastasis, ece was further investigated for various c ... | 2011 | 25214119 |
| fucodiphlorethol g purified from ecklonia cava suppresses ultraviolet b radiation-induced oxidative stress and cellular damage. | fucodiphlorethol g (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from ecklonia cava, a brown alga that is widely distributed offshore of jeju island. this study investigated the protective effects of fucodiphlorethol g against oxidative damage-mediated apoptosis induced by ultraviolet b (uvb) irradiation. fucodiphlorethol g attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in ... | 2014 | 25143808 |
| 6,6'-bieckol isolated from ecklonia cava protects oxidative stress through inhibiting expression of ros and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells. | hyperglycemia-induced oxidative stress accelerates endothelial cell dysfunctions, which cause various complications of diabetes. the protective effects of 6,6'-bieckol (bek), one of phlorotannin compound purified from ecklonia cava against high-glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (huvecs), which is susceptible to oxidative stress. high glucose (30 mm) treatment induced huvecs' cell death, but bek, at concentration 10 or 50 μg/ml, signifi ... | 2014 | 25086922 |
| comparison of ecklonia cava, ecklonia stolonifera and eisenia bicyclis for phlorotannin extraction. | phlorotannins are polyphenols of marine algae, particularly brown seaweed, having multiple biological activities. a reverse phase-high performance liquid chromatography method was developed for rapid and routine quantification of two major phlorotannins, dieckol and phlorofucofuroeckol-a (pfe-a), from boiling water- and organic solvent-extracts of brown seaweeds ecklonia cava, e. stolonifera and eisenia bicyclis. the regression equations for dieckol and pfe-a were as follows: the concentration ( ... | 2014 | 25004758 |
| the edible brown seaweed ecklonia cava reduces hypersensitivity in postoperative and neuropathic pain models in rats. | the current study was designed to investigate whether edible brown seaweed ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (sni) rats. to evaluate pain-related behavior, we performed the mechanical withdrawal threshold (mwt) and thermal hypersensitivity tests measured by von frey filaments and a hot/cold plate analgesia meter. pain-related behavior was also determined through analysis of ultrasonic vocalization. the results of experiments showed mwt ... | 2014 | 24918539 |
| enrichment and purification of marine polyphenol phlorotannins using macroporous adsorption resins. | phlorotannins are one of the most important bioactive polyphenols; however, their purification using chromatographic methods has not been explored. here, we studied purification of phlorotannins from the crude phlorotannin extract (cphe) of the brown seaweed ecklonia cava using macroporous adsorption resins. for purification of phlorotannins, four resins (hp-20, sp-850, xad-7hp, and xad-2) were screened. among them, hp-20 resin showed the highest adsorption and desorption capacities. in static a ... | 2014 | 24874368 |
| antioxidant marine algae phlorotannins and radioprotection: a review of experimental evidence. | radiation has been widely used for cancer therapy in human medicine. however, the side effects of radiation are problematic and can limit its application. radiation generates reactive oxygen species, leading to cell death via multiple signaling pathways. the blocking of certain signaling cascades using antioxidants represents a compensatory therapy of radiation-induced tissue injury. although synthetic chemicals have been investigated in recent decades, anti-oxidants from natural resources have ... | 2014 | 24751171 |
| electrospun pcl/phlorotannin nanofibres for tissue engineering: physical properties and cellular activities. | micro/nanofibrous substrates have been widely used for tissue regeneration because of their similarities to extracellular matrix components and their high surface area, which facilitates attachment and proliferation of cells. phlorotannin, the main component of the brown alga ecklonia cava, contains various growth factors that promote the regeneration of various tissues, including bone, by stimulating alkaline phosphatase (alp) activity and inducing calcium deposition. despite the benefits of ph ... | 2012 | 24751081 |
| molecular characteristics and anti-inflammatory activity of the fucoidan extracted from ecklonia cava. | enzymatic extraction has been successfully used for extracting numerous biologically active compounds from a wide variety of seaweeds. in this study, we found that enzymatic extraction of the fucoidan from ecklonia cava may be more advantageous than water extraction. therefore, we studied the e. cava fucoidans extracted by the enzymatic extraction technique and used ion-exchange chromatography to determine their molecular characteristics and anti-inflammatory activities. the crude and fractionat ... | 2012 | 24750764 |
| suppression of nf-κb by dieckol extracted from ecklonia cava negatively regulates lps induction of inducible nitric oxide synthase gene. | dieckol, extracted from brown algae, ecklonia cava, is suggested to elicit anti-inflammatory or anti-tumorigenic activities. however, dieckol-mediated regulatory mechanism for inflammatory response still remains elusive. here, we show that dieckol suppressed lipopolysaccharide (lps)-induced inducible nitric oxide synthase (inos) expression in mouse leukemic macrophage raw264.7 cells. also, dieckol decreased lps-induced both nitric oxide (no) production and inos promoter-driven transcriptional ac ... | 2014 | 24744158 |
| preparative isolation and purification of phlorotannins from ecklonia cava using centrifugal partition chromatography by one-step. | various bioactive phlorotannins of ecklonia cava (e.g., dieckol, eckol, 6,6-bieckol, phloroglucinol, phloroeckol, and phlorofucofuroeckol-a) are reported. however, their isolation and purification are not easy. centrifugal partition chromatography (cpc) can be used to efficiently purify the various bioactive-compounds efficiently from e. cava. phlorotannins are successfully isolated from the ethyl acetate (etoac) fraction of e. cava by cpc with a two-phase solvent system comprising n-hexane:etoa ... | 2014 | 24731366 |
| cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: involvement of the foxo3a/ampk pathway. | this study investigated the cytoprotective effect of ecklonia cava-derived eckol against h2o2-induced mitochondrial dysfunction in chang liver cells. while h2o2 augmented levels of mitochondrial reactive oxygen species (ros), eckol decreased it. eckol also attenuated high intracellular ca(2+) levels stimulated by h2o2 and recovered h2o2-diminished atp levels and succinate dehydrogenase activity. eckol time-dependently increased the expression of manganese superoxide dismutase (mn sod), a mitocho ... | 2014 | 24700636 |
| water soluble sulfated-fucans with immune-enhancing properties from ecklonia cava. | water-soluble sulfated fucans isolated from ecklonia cava were fractionated using an anion-exchange chromatography to investigate their molecular characteristics and immunomodulating activities. the crude fucoidan extract and purified fractions (ef1, ef2, and ef3) consisted mostly of different ratios of neutral sugars, proteins, sulfates, uronic acids, and their monosaccharide compositions were also significantly different. the backbone of the most immunoenhancing fraction, ef2, was mainly linke ... | 2014 | 24661888 |
| protective effect of the edible brown alga ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | as part of our efforts to isolate anti-hepatotoxic agents from marine natural products, we screened the ability of 14 edible varieties of korean seaweed to protect against doxorubicin-induced hepatotoxicity in primary rat hepatocytes. | 2014 | 24628384 |
| effects of the addition of ecklonia cava powder on the selected physicochemical and sensory quality of white pan bread. | physicochemical properties and consumer perception of white pan bread as influenced by the addition of ecklonia cava powder (ecp) were investigated. freeze-dried ecklonia cava were ground, sieved through a laboratory sieve and a fraction with particles less than 250 μm was used. amount of ecp added (0~3%) to the bread was found to affect the bread quality significantly (p<0.05). ph, bread height, and volume of the control was significantly higher than others (p<0.05) and decreased significantly ... | 2013 | 24551832 |
| marine algae-mediated synthesis of gold nanoparticles using a novel ecklonia cava. | in the present study, we report rapid biological synthesis of gold nanoparticles (au nps) using a novel marine brown alga ecklonia cava (family: lessoniaceae) by the reduction of chloroauric acid. the formation of au nps reaction was complete within 1 min at 80 °c and physiochemically characterized with different analytical techniques. ftir spectroscopy revealed that au nps were functionalized with biomolecules that have primary amine group, hydroxyl group and other stabilizing functional groups ... | 2014 | 24525832 |
| protective effect of fucoidan against aaph-induced oxidative stress in zebrafish model. | fucoidan, extracted from ecklonia cava, has been extensively studied because of its wide biological activities. however, antioxidative activities have not been yet examined. therefore we evaluated in vitro and in vivo studies on antioxidative activities of e. cava fucoidan (ecf). ecf exhibited more prominent effects in peroxyl radical scavenging activity, compared to the other scavenging activities. thus, ecf was further evaluated for its protective ability against 2,2'-azobis dihydrochloride in ... | 2014 | 24507271 |
| alleviating effects of baechu kimchi added ecklonia cava on postprandial hyperglycemia in diabetic mice. | in this study, we investigated the inhibitory effects of baechu kimchi added ecklonia cava on the activities of α-glucosidase and α-amylase and its alleviating effect on the postprandial hyperglycemia in stz-induced diabetic mice. baechu kimchi added ecklonia cava (bke, 15%) was fermented at 5°c for 28 days. optimum ripened bke was used in this study as it showed the strongest inhibitory activities on α-glucosidase and α-amylase by fermentation time among the bkes in our previous study. the bke ... | 2013 | 24471127 |
| anti-hyperlipidemic effect of polyphenol extract (seapolynol(™)) and dieckol isolated from ecklonia cava in in vivo and in vitro models. | the inhibitory effect of polyphenol extracts (seapolynol(™), spn) of the marine brown algae ecklonia cava and dieckol, a major component of spn, on hyperlipidemia was investigated in icr mice fed a high-fat diet (hfd) for five weeks. for analysis of the anti-hyperlipidemic effects of spn and dieckol, these two agents were given orally on a daily basis to hfd-fed mice for four weeks, starting one week after the beginning of hfd feeding. groups administered with spn as well as dieckol showed lower ... | 2012 | 24471056 |
| inhibitory effects of brown algae extracts on histamine production in mackerel muscle via inhibition of growth and histidine decarboxylase activity of morganella morganii. | this study was performed to investigate the inhibitory effects of brown algae extracts on histamine production in mackerel muscle. first, antimicrobial activities of brown algae extracts against morganella morganii were investigated using a disk diffusion method. an ethanol extract of ecklonia cava (ecee) exhibited strong antimicrobial activity. the minimum inhibitory concentration (mic) of ecee was 2 mg/ml. furthermore, the brown algae extracts were examined for their ability to inhibit crude h ... | 2014 | 24394193 |
| ecklonia cava promotes hair growth. | previous studies have reported the protective effects on skin elasticity of the edible marine seaweed ecklonia cava, which acts through regulation of both antioxidative and anti-inflammatory responses. | 2013 | 24252083 |
| dieckol, a phlorotannin isolated from a brown seaweed, ecklonia cava, inhibits adipogenesis through amp-activated protein kinase (ampk) activation in 3t3-l1 preadipocytes. | in this study, we assessed the potential inhibitory effect of 5 species of brown seaweeds on adipogenesis the differentiation of 3t3-l1 preadipocytes into mature adipocytes by measuring oil-red o staining. the ecklonia cava extract tested herein evidenced profound adipogenesis inhibitory effect, compared to that exhibited by the other four brown seaweed extracts. thus, e. cava was selected for isolation of active compounds and finally the three polyphenol compounds of phlorotannins were obtained ... | 2013 | 24211593 |
| protective effect of dieckol isolated from ecklonia cava against ethanol caused damage in vitro and in zebrafish model. | in the present study, the protective effects of phlorotannins isolated from ecklonia cava against ethanol-induced cell damage and apoptosis were investigated both in vitro and in vivo. three phlorotannin compounds, namely phloroglucinol, eckol and dieckol, were successively isolated and identified from the extract. dieckol showed the strongest protective effect against ethanol-induced cell apoptosis in chang liver cells, with the lowest cytotoxicity. it was observed that dieckol reduced cell apo ... | 2013 | 24189014 |
| evaluation of inhibitory effect of phlorotannins from ecklonia cava on triglyceride accumulation in adipocyte. | in the present study, a methanolic extract of ecklonia cava and its solvent-partitioned fractions were evaluated for their antiadipogenic effect in 3t3-l1 adipocytes. one of them, the n-buoh fraction, effectively reduced lipid accumulation and glucose consumption. in addition, the presence of the n-buoh fraction in adipocytes suppressed the regulations of adipogenic transcription factors, pparγ and srebp1c, and adipogenic specific genes, fabp4, fabp1, fas, lpl, hsl, and acs1. further purificatio ... | 2013 | 23957842 |
| in vitro antiviral activity of phlorotannins isolated from ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination. | despite the prepdominat agent causing severe entero-pathogenic diarrhea in swine, there are no effective therapeutical treatment of porcine epidemic diarrhea virus (pedv). in this study, we evaluated the antiviral activity of five phlorotannins isolated from ecklonia cava (e. cava) against pedv. in vitro antiviral activity was tested using two different assay strategies: (1) blockage of the binding of virus to cells (simultaneous-treatment assay) and (2) inhibition of viral replication (post-tre ... | 2013 | 23746631 |
| studies on technology for seaweed forest construction and transplanted ecklonia cava growth for an artificial seaweed reef. | we installed seaweed reef for restoration of barron ground coast. we hollowed out a u-shaped groove in a cross-shaped artificial seaweed reef and covered it with a zinc sheet (u-bar) to transplant ecklonia cava growing on dellenia wood by hand, installing the u-bar on the artificial seaweed reef, fixing it with concrete. thus seaweed can be attached easily, with pre-installed stainless bolts and nuts. the length of ecklonia cava leaf transplanted to the cross-shaped reef was 7.2 cm in february 2 ... | 2012 | 23734467 |
| dieckol, a sars-cov 3cl(pro) inhibitor, isolated from the edible brown algae ecklonia cava. | sars-cov 3cl(pro) plays an important role in viral replication. in this study, we performed a biological evaluation on nine phlorotannins isolated from the edible brown algae ecklonia cava. the nine isolated phlorotannins (1-9), except phloroglucinol (1), possessed sars-cov 3cl(pro) inhibitory activities in a dose-dependently and competitive manner. of these phlorotannins (1-9), two eckol groups with a diphenyl ether linked dieckol (8) showed the most potent sars-cov 3cl(pro) trans/cis-cleavage ... | 2013 | 23647823 |
| cytoprotective effect of dieckol on human endothelial progenitor cells (hepcs) from oxidative stress-induced apoptosis. | although endothelial progenitor cells (epcs) have been used to promote revascularization after peripheral or myocardial ischemia, excess amounts of reactive oxygen species (ros) are often involved in senescence and apoptosis of epcs, thereby causing defective neovascularization and reduced or failed recovery. here, we examined the cytoprotective effect of ecklonia cava-derived antioxidant dieckol (dk) on oxidative stress-induced apoptosis in epcs to improve epc bioactivity for vessel repair. alt ... | 2013 | 23607503 |
| protective effect of marine algae phlorotannins against aaph-induced oxidative stress in zebrafish embryo. | in this study the protective effect of phlorotannins, including phloroglucinol, eckol, dieckol, eckstolonol and triphloroethol a, isolated from brown algae ecklonia cava was investigated against aaph-induced oxidative stress toxicity in zebrafish embryos. zebrafish embryos were exposed to aaph and compared with other groups that were co-exposed with phlorotannins until 2-days post-fertilisation. all phlorotannins scavenged intracellular ros and prevented lipid peroxidation and reduced aaph-induc ... | 2013 | 23411200 |
| the jnk/nfkappab pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from ecklonia cava. | the proven immunomodulatory and immune system activating properties of ecklonia cava (e. cava) have been attributed to its plentiful polysaccharide content. therefore, we investigated whether the sulfated polysaccharide (sp) of e. cava specifically activates the protein kinases (mapks) and nuclear factor-kappab (nfkappab) to incite immune responses. | 2013 | 23262141 |
| dieckol isolated from brown seaweed ecklonia cava attenuates type іі diabetes in db/db mouse model. | in the present study, the attenuation of type іі diabetes by dieckol, a phlorotannin derivative isolated from brown seaweed, ecklonia cava was investigated in c57bl/ksj-db/db, a type іі diabetes mouse model. dieckol was administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight diabetes mice for 14 days. the blood glucose level, serum insulin level and body weight were significantly reduced in the dieckol administered group, compared to that of the saline administered group. ... | 2013 | 23261675 |
| anti-inflammatory effect of fucoidan extracted from ecklonia cava in zebrafish model. | fucoidan extracted from ecklonia cava had strong anti-inflammatory activities. however, the direct effects of fucoidan of e. cava on anti-inflammatory activities in vivo model remained to be determined. therefore, the present study was designed to assess in vivo anti-inflammatory effect of fucoidan extracted from e. cava (ecf) using tail-cutting-induced and lipopolysaccharide (lps)-stimulated zebrafish model. treating zebrafish model with tail-cutting and lps-treatment significantly increased th ... | 2013 | 23218269 |
| effects of ecklonia cava polyphenol in individuals with hypercholesterolemia: a pilot study. | we evaluated the efficacy and safety of ecklonia cava polyphenol (seapolynol™, a polyphenol antioxidant and anti-inflammatory agent purified from e. cava) during a 12-week treatment period (400 mg orally once daily) in individuals with hypercholesterolemia and performed subgroup analysis for metabolic syndrome (mets). as a noncomparative study, forty-six individuals (m:f=22:24, mean age=54±11 years) with fasting total cholesterol concentration >240 mg/dl or low-density lipoprotein cholesterol (l ... | 2012 | 23126663 |
| phloroglucinol protects small intestines of mice from ionizing radiation by regulating apoptosis-related molecules: a comparative immunohistochemical study. | phloroglucinol (pg) is a phenolic compound isolated from ecklonia cava, a brown algae abundant on jeju island, korea. previous reports have suggested that pg exerts antioxidative and cytoprotective effects against oxidative stress. in this study, we confirmed that pg protected against small intestinal damage caused by ionizing radiation, and we investigated its protective mechanism in detail. regeneration of intestinal crypts in the pg-treated irradiated group was significantly promoted compared ... | 2013 | 23117934 |
| radio-protective effect of polysaccharides isolated from lactobacillus brevis-fermented ecklonia cava. | we investigated the radioprotective effects of a polysaccharide isolated from enzymatic extracts of ecklonia cava (e. cava) fermented by fungi and bacteria. we identified that the aqueous extract of the lactobacillus brevis-fermented e. cava especially showed the highest proliferation effect. in addition, the enzymatic extract prepared by enzyme-assisted extraction using viscozyme (vlfe) significantly increased cell proliferation. further study indicated that the polysaccharides isolated from th ... | 2013 | 23068138 |
| phlorotannin-rich ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity. | beta-amyloid (aβ) is a major pathogenic peptide in alzheimer's disease (ad) and is generated by the processing of amyloid precursor protein (app). we have previously reported that the brown algae ecklonia cava, which has anti-oxidant and anti-inflammatory functions, decreased aβ production and further aggregation in hek293 cells expressing the app swedish mutation. here, we show the reduction mechanism of aβ production using the butanol extract of ecklonia cava through the examination of express ... | 2013 | 23041113 |
| photo-oxidative stress by ultraviolet-b radiation and antioxidative defense of eckstolonol in human keratinocytes. | ultraviolet-b (uv-b) irradiation has been known to generate oxidative stress by increasing reactive oxygen species (ros) in skin cells. several naturally occurring antioxidant compounds isolated from marine algae are believed to protect against ros. in this study, we assessed the antioxidative effect of eckstolonol isolated from ecklonia cava against uv-b-induced ros in human keratinocytes (hacats). we investigated the effects of photo-oxidative stress by uv-b (50 mj/cm(2)) and the antioxidative ... | 2012 | 22999063 |
| dieckol isolated from ecklonia cava protects against high-glucose induced damage to rat insulinoma cells by reducing oxidative stress and apoptosis. | pancreatic β cells are very sensitive to oxidative stress and this might play an important role in β cell death with diabetes. the protective effect of dieckol, one of the phlorotannin polyphenol compounds purified from ecklonia cava (e. cava), against high glucose-induced oxidative stress was investigated by using rat insulinoma cells. a high-glucose (30 mm) treatment induced the death of rat insulinoma cells, but dieckol, at a concentration 17.5 or 70 µm, significantly inhibited the high-gluco ... | 2012 | 22878185 |
| polyphenol-rich fraction of brown alga ecklonia cava collected from gijang, korea, reduces obesity and glucose levels in high-fat diet-induced obese mice. | ecklonia cava (e. cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes. however, the effects of e. cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined. we investigated the effects of e. cava on body weight, fat content, and hyperglycemia in high-fat diet- (hfd) induced obese mice and sought the mechanisms involved. c57bl/6 male mice were fed a hfd (60% fat) diet or normal chow. after 3 weeks, the hfd diet group was gi ... | 2012 | 22844333 |
| protective efficacy of an ecklonia cava extract used to treat transient focal ischemia of the rat brain. | phlorotannins (marine algal polyphenols) have been reported to exhibit beneficial biological activities, serving as both antioxidants and anti-inflammatory agents. among marine algae, ecklonia cava, a member of the laminariaceae, is a very popular food regarded as healthy in korea and japan. recently, benefits afforded by phlorotannins in the treatment of various clinical conditions have been reported, but any therapeutic effects of such materials in the treatment of neurodegenerative diseases s ... | 2012 | 22822465 |
| effect of dieckol, a component of ecklonia cava, on the promotion of hair growth. | this study was conducted to evaluate the effect of ecklonia cava, a marine alga native to jeju island in korea, on the promotion of hair growth. when vibrissa follicles were cultured in the presence of e. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, e. cava enzymatic extract increased hair-fiber length. in addition, after topical application of the 0.5% e. cava enzymatic extract onto the back of c57bl/6 mice, anagen progression of the hair-shaft was induced. the ... | 2012 | 22754373 |
| eckol inhibits ultraviolet b-induced cell damage in human keratinocytes via a decrease in oxidative stress. | in previous reports, the antioxidant effects of eckol were shown to protect cells against hydrogen peroxide- and gamma ray-induced oxidative stress. in this study, the role of eckol in protecting human skin keratinocytes (hacat) against uvb-induced oxidative cell damage was investigated. also, triphlorethol-a, one of the chemical components in ecklonia cava, and quercetin a well known antioxidant, were compared with eckol in terms of antioxidant activity based on chemical structure. eckol decrea ... | 2012 | 22687478 |
| ecklonia cava inhibits glucose absorption and stimulates insulin secretion in streptozotocin-induced diabetic mice. | aims of study. present study investigated the effect of ecklonia cava (ec) on intestinal glucose uptake and insulin secretion. materials and methods. intestinal na(+)-dependent glucose uptake (sgu) and na(+)-dependent glucose transporter 1 (sglt1) protein expression was determined using brush border membrane vesicles (bbmvs). glucose-induced insulin secretion was examined in pancreatic β-islet cells. the antihyperglycemic effects of ec, sgu, and sglt1 expression were determined in streptozotocin ... | 2012 | 22645628 |
| bioactive compounds extracted from ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in ins-1 pancreatic β-cells. | pancreatic β-cells are very sensitive to oxidative stress and this might play an important role in β-cell death in diabetes. in the present study, we investigated whether the brown alga ecklonia cava has protective effects against high glucose-induced damage in ins-1 pancreatic β-cells. for that purpose, we prepared an enzymatic hydrolysate from e. cava (ehe) by using the carbohydrase, celluclast. high-glucose (30 mm) treatment induced glucotoxicity, whereas ehe prevented cells from high glucose ... | 2012 | 22644639 |
| insulinotrophic and hypolipidemic effects of ecklonia cava in streptozotocin-induced diabetic mice. | to explore the anti-diabetic activity of ecklonia cava (ec) in streptozotocin (stz)-induced diabetic mice. | 2012 | 22546654 |
| hepatoprotective effects of dieckol-rich phlorotannins from ecklonia cava, a brown seaweed, against ethanol induced liver damage in balb/c mice. | alcoholic liver disease, which is one of the most serious liver disorders, has been known to cause by ethanol intake. in the present study, in vivo hepatoprotective effects of dieckol-rich phlorotannins (drp) from ecklonia cava, a brown seaweed, on ethanol induced hepatic damage in balb/c mice liver were investigated. after administration of 5 and 25mg/kg mouse of drp and 4 g/kg mice ethanol, the body weights and survival rates were increased as compared to the control, which is ethanol-treated ... | 2012 | 22504843 |
| phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in llc-tumor-bearing mice. | there is increasing evidence that phloroglucinol, a compound from ecklonia cava, induces the apoptosis of cancer cells, eventually suppressing tumor angiogenesis. | 2012 | 22496756 |
| neuroprotective effects of phlorotannins isolated from a brown alga, ecklonia cava, against h2o2-induced oxidative stress in murine hippocampal ht22 cells. | exposure of neurons to hydrogen peroxide (h(2)o(2)) results in oxidative stress and the activation of a cascade of intracellular toxic events resulting in oxidation, lipid peroxidation, and ca(2+) elevation, ultimately resulting in cell death. in this study, we attempted to characterize the neuroprotective effects of phlorotannins isolated from ecklonia cava, including phloroglucinol, eckol, triphloroethol a, eckstolonol, and dieckol, against h(2)o(2)-induced cell damage in murine hippocampus ne ... | 2012 | 22465981 |
| antioxidant dieckol downregulates the rac1/ros signaling pathway and inhibits wiskott-aldrich syndrome protein (wasp)-family verprolin-homologous protein 2 (wave2)-mediated invasive migration of b16 mouse melanoma cells. | reactive oxygen species (ros) generation is linked to dynamic actin cytoskeleton reorganization, which is involved in tumor cell motility and metastasis. thus, inhibition of ros generation and actin polymerization in tumor cells may represent an effective anticancer strategy. however, the molecular basis of this signaling pathway is currently unknown. here, we show that the ecklonia cava-derived antioxidant dieckol downregulates the rac1/ros signaling pathway and inhibits wiskott-aldrich syndrom ... | 2012 | 22441674 |
| ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats. | the development of alcoholic liver disease is a complex process that involves both the parenchymal and non-parenchymal cells of the liver. we examined the effect of an ecklonia cava extract on ethanol-induced liver injury. | 2012 | 22387226 |
| inhibitory effects of ecklonia cava extract on high glucose-induced hepatic stellate cell activation. | nonalcoholic steatohepatitis (nash) is a disease closely associated with obesity and diabetes. a prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. here, we examined the effects of an extract of ecklonia cava, a brown algae, on the activation of high glucose-induced hepatic stellate cells (hscs), key players in hepatic fibrosis. isolated hscs were incubated with or without a high glucose concentration. ecklonia cava extrac ... | 2011 | 22363250 |
| 6,6'-bieckol, isolated from marine alga ecklonia cava, suppressed lps-induced nitric oxide and pge₂ production and inflammatory cytokine expression in macrophages: the inhibition of nfκb. | ecklonia cava is an edible brown alga that contains high levels of phlorotannins, which are unique marine polyphenolic compounds. in the present study, we investigated the anti-inflammatory effects and the underlying molecular mechanism of phlorotannin 6,6'-bieckol, which is an active component isolated from e. cava, on lipopolysaccharide (lps)-stimulated primary macrophages and raw 264.7 macrophage cells. 6,6'-bieckol was found to inhibit nitric oxide (no) and prostaglandin e₂ (pge₂) production ... | 2012 | 22289571 |
| dieckol from ecklonia cava suppresses the migration and invasion of ht1080 cells by inhibiting the focal adhesion kinase pathway downstream of rac1-ros signaling. | we have previously isolated dieckol, a nutrient polyphenol compound, from the brown alga, ecklonia cava (lee et al.,2010a). dieckol shows both antitumor and antioxidant activity and thus is of special interest for the development of chemopreventive and chemotherapeutic agents against cancer. however, the mechanism by which dieckol exerts its antitumor activity is poorly understood. here, we show that dieckol, derived from e. cava, inhibits migration and invasion of ht1080 cells by scavenging int ... | 2012 | 22286230 |