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occurrence of corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a tunisian hospital.corynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. we investigated the susceptibility of 63 c. striatum isolated at the farhat-hached hospital, sousse (tunisia), during the period 2011-2014, to a panel of 16 compounds belonging to the main clinically relevant classes of antimicrobial agents. all strains were susceptible to vancomycin, linezolid, and daptomycin. amikacin and g ...201728848236
when good bugs go bad: epidemiology and antimicrobial resistance profiles of corynebacterium striatum, an emerging multidrug resistant, opportunistic pathogen.infections with corynebacterium striatum have been described in the literature over the last two decades, with the majority being bacteremia, central line infections, and occasionally endocarditis. in recent years, the frequency of c. striatum infections appears to be increasing; a likely factor contributing to this is the increased ease and accuracy of the identification of corynebacterium spp., including c. striatum, from clinical cultures. the objective of this study was to retrospectively ch ...201728848008
cutaneous corynebacterium infection presenting with disseminated skin nodules and ulceration.in the context of the european migrant crisis, more and more cases of cutaneous diphtheria are seen. a typical presentation includes painful cutaneous ulcerations with grayish-whitish pseudomembranes. here we present 2 male eritrean patients suffering from cutaneous nontoxigenic corynebacterium diphtheriae (patient 1) and corynebacterium striatum (patient 2) infection.201728611629
bacterial contaminants from frozen puff pastry production process and their growth inhibition by antimicrobial substances from lactic acid bacteria.seventy-five bacterial contaminants which still persisted to cleaning system from three puff pastry production lines (dough forming, layer and filling forming, and shock freezing) were identified using 16s rdna as seven genera of bacillus, corynebacterium, dermacoccus, enterobacter, klebsiella, pseudomonas, and staphylococcus with detection frequencies of 24.00, 2.66, 1.33, 37.33, 1.33, 2.66, and 30.66, respectively. seventeen species were discovered while only 11 species bacillus cereus, b. sub ...201728572930
the left atrial bacterial vegetative mass due to corynebacterium striatum as a presentation of myxoma: a case report.corynebacterium striatum is a member of the non-diphtherial corynebacteria, which are ubiquitous in nature and generally colonize the skin and mucous membranes of humans. rarely, it causes infective endocarditis (ie). we report a case of rare left atrial bacterial vegetative mass due to c. striatum masquerading as a myxoma identified through a tortuous diagnostic process, and present a brief review of the relevant literature.201728549450
development of high-grade daptomycin resistance in a patient being treated for corynebacterium striatum infection. 201728483949
septic arthritis in a native knee due to corynebacterium striatum.we describe a case of septic arthritis in a native knee due to corynebacterium striatum, gram-positive bacilli that are usually commensal organisms of skin and mucosal membranes, but are seldom implicated in native septic arthritis. an 84-year-old man with corynebacterium striatum septic arthritis of his native left knee and no response to conventional antibiotic therapy. thus, the patient was allowed to take dalbavancin for compassionate use, with an excellent clinical outcome. this case emphas ...201728283311
infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves.this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves.201728279319
diphtheroids-important nosocomial pathogens.diphtheroids are defined as aerobic, non-sporulating, pleomorphic gram-positive bacilli which are more uniformly stained than corynebacterium diphtheriae, lack the metachromatic granules and are arranged in a palisade manner. they are usually commensals of the skin and mucous membranes. they differ from c.diphtheriae in biochemical rea-ctions as well as in toxin production. since, they are usually found as commensals on the skin, they are often considered as mere contaminants when isolated from ...201628208859
corynebacterium striatum bacteremia associated with a catheter-related blood stream infection.a 49-year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. it progressed to disseminated intravascular coagulation and disturbance of consciousness on day 67 of admission. gram-positive bacilli were detected from two different blood culture samples on day 67 of admission. an api-coryne test and sequencing (1~615 bp) of the 16s rrna gene were performed, and the strain was identified as corynebacterium striatum. the bacteri ...201728197349
[chronic osteomyelitis due to corynebacterium striatum in a female adolescent].a case of a girl with chronic posttraumatic osteomyelitis of the right tibia with microbiological isolation of bacillus spp. by conventional methods and confirmation by mass spectrometry maldi-tof (matrix-assisted laser desorption/ionization time-of-flight mass) of corynebacterium striatum is presented. diagnostic methods, clinical manifestations, and resistance pattern of these infections are described.201628146197
rapid transmission of multidrug-resistant corynebacterium striatum among susceptible patients in a tertiary hospital in china.with increasing reports about corynebacterium striatum, its potential pathogenicity and clinical significance are drawing more attention in recent years.201628036309
clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients.we examined the clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients.201728011352
susceptibility to aminoglycosides and distribution of aph and aac(3)-xi genes among corynebacterium striatum clinical isolates.corynebacterium striatum is an opportunistic pathogen, often multidrug-resistant, which has been associated with serious infections in humans. aminoglycosides are second-line or complementary antibiotics used for the treatment of corynebacterium infections. we investigated the susceptibility to six aminoglycosides and the molecular mechanisms involved in aminoglycoside resistance in a collection of 64 corynebacterium striatum isolated in our laboratory during the period 2005-2009. antimicrobial ...201627936101
a case of fatal sepsis due to multidrug-resistant corynebacterium striatum.although non-diphtheria corynebacteria have traditionally been regarded as avirulent members of human bacterial flora, their pathogenic potential is increasingly recognized in our time. reasons for this include the prolonged survival of severely ill and immunocompromised patients, the development of more invasive diagnostic and therapeutic procedures and the sub-optimal use of antibiotics that disrupts normal microbial balance and favors superinfections.201727895446
multidrug-resistant corynebacterium striatum associated with increased use of parenteral antimicrobial drugs. 201627767926
an unusual case of corynebacterium striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease.corynebacterium striatum (c. striatum) is a ubiquitous saprophyte with a potential to cause bacteremia. we report the first case of c. striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease.201627751312
an extremely rare case of tubo-ovarian abscesses involving corynebacterium striatum as causative agent.we present an extremely rare case of tubo-ovarian abscesses involving corynebacterium striatum (c. striatum) as causative agent in a 53-year-old woman.201627686475
rare case of corynebacterium striatum septic arthritis.corynebacterium species are aerobic, gram-positive bacilli that are commensal organisms of skin and mucosal membranes. although its pathogenicity is well established, corynebacterium striatum is frequently isolated in cultures and generally regarded as a contaminant. rarely, this bacterium causes septic arthritis. we present a case of right shoulder joint septic arthritis due to c. striatum in a lung-transplant recipient with end-stage renal disease. a brief review of the literature regarding c. ...201627664229
native valve endocarditis due to corynebacterium striatum confirmed by 16s ribosomal rna sequencing: a case report and literature review.corynebacterium species are non-fermentous gram-positive bacilli that are normal flora of human skin and mucous membranes and are commonly isolated in clinical specimens. non-diphtheriae corynebacterium are regarded as contaminants when found in blood culture. currently, corynebacterium striatum is considered one of the emerging nosocomial agents implicated in endocarditis and serious infections. we report a case of native-valve infective endocarditis caused by c. striatum, which was misidentifi ...201627659439
clinical and bacteriological analyses of bacteremia due to corynebacterium striatum.corynebacterium striatum was recently recognized as a potential pathogen of various infectious diseases. however, the clinical entity of this microorganism has not been clearly identified. therefore, we analyzed c. striatum isolates from blood culture and explored their clinical determinants.201627654073
clinical significance of commensal gram-positive rods routinely isolated from patient samples.commensal bacteria from the skin and mucosal surfaces are routinely isolated from patient samples and considered contaminants. the majority of these isolates are catalase-positive gram-positive rods from multiple genera routinely classified as diphtheroids. these organisms can be seen upon gram staining of clinical specimens or can be isolated as the predominant or pure species in culture, raising a priori suspicion of a possible involvement in infection. with the development and adoption of mat ...201627629905
staphylococcus aureus shifts toward commensalism in response to corynebacterium species.staphylococcus aureus-human interactions result in a continuum of outcomes from commensalism to pathogenesis. s. aureus is a clinically important pathogen that asymptomatically colonizes ~25% of humans as a member of the nostril and skin microbiota, where it resides with other bacteria including commensal corynebacterium species. commensal corynebacterium spp. are also positively correlated with s. aureus in chronic polymicrobial diabetic foot infections, distinct from acute monomicrobial s. aur ...201627582729
[corynebacterium striatum meningitis]. 201627461372
characteristics of multidrug-resistant corynebacterium spp. isolated from blood cultures of hospitalized patients in japan.corynebacterium is a genus consisting of gram-positive, rod-shaped bacteria, that is wildly distributed in nature. we report the epidemiological characterization of corynebacterium spp. isolated from blood specimens at the kurume university hospital, between june 2008 and november 2011. twenty-two strains that were likely corynebacterium spp. were isolated from 22 hospitalized patients, of which 12 (54.5%) were identified as corynebacterium striatum. minimum inhibitory concentration tests were p ...201727357981
[native valve endocarditis due to corynebacterium striatum; report of a case].we recently encountered a case of native valve endocarditis caused by corynebacterium striatum (c. striatum) in the absence of immunosuppression and a prosthetic valve. a 49-year-old woman was urgently admitted for disturbance of consciousness and nosebleeds. careful clinical examination revealed infective endocarditis caused by c. striatum, for which replacement of aortic and mitral valves was performed. the postoperative course was favorable, and we were able to save the patient with no postop ...201627220933
cellulitis and bacteremia due to corynebacterium striatum identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry.corynebacterium striatum has been described as a pathogen in immunocompromised patients; however, correctly identifying corynebacterium spp. is often difficult, and cases of cellulitis caused by c. striatum are only rarely reported. we herein describe a case of cellulitis and bacteremia due to c. striatum identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. antimicrobial susceptibility testing was performed using the strepto-haemo supplement method, and van ...201627150881
corynebacterium striatum empyema and osteomyelitis in a patient with advanced rheumatoid arthritis.corynebacterium striatum, which is a common coloniser of human skin and mucous membranes, is increasingly being recognised as an emerging pathogen. we present a case of a 69-year-old woman with empyema and osteomyelitis caused by c. striatum. to the best of our knowledge, this is the first case where these two infections from this bacterium were identified together in the same individual.201626944378
[acute exacerbation of bronchiectasis: imputability of a corynebacterium striatum infection?]. 201626795081
relapsing bacteraemia due to corynebacterium striatum in a patient with peripheral arterial disease.we describe the first reported case of corynebacterium striatum (c. striatum) relapsing bacteraemia in a patient with peripheral arterial disease and proven corynebacterium species colonization of a chronic foot ulcer, focusing on the difficulties in the management of the patient. we conclude that the optimal duration of the antibiotic treatment for relapsing c. striatum bacteraemia from a chronic ulcer should be 6 weeks together with surgical treatment.201526638539
emergence of high-level daptomycin resistance in corynebacterium striatum in two patients with left ventricular assist device infections.we describe the clinical and microbiologic courses of two patients with ventricular assist device infections secondary to corynebacterium striatum treated with daptomycin. in both cases, the pathogen was initially susceptible to daptomycin (minimum inhibitory concentration [mic] <0.125 mg/l) but became resistant (mic >256 mg/l) during therapy.201626544621
draft genome sequence of corynebacterium striatum 1961 br-rj/09, a multidrug-susceptible strain isolated from the urine of a hospitalized 37-year-old female patient.corynebacterium striatum commonly colonizes the normal skin and nasopharyngeal tract of humans; however, this potentially pathogenic bacterium has been identified as the causative agent of several nosocomial infections. the current study describes the draft genome of strain 1961 br-rj/09, isolated from the urine of a hospitalized patient from brazil.201526251495
central venous catheter-related bloodstream infection by corynebacterium striatum identified by 16s rrna and rpob gene sequencing. 201526206696
aac(3)-xi, a new aminoglycoside 3-n-acetyltransferase from corynebacterium striatum.corynebacterium striatum bm4687 was resistant to gentamicin and tobramycin but susceptible to kanamycin a and amikacin, a phenotype distinct among gram-positive bacteria. analysis of the entire genome of this strain did not detect any genes for known aminoglycoside resistance enzymes. yet, annotation of the coding sequences identified 12 putative acetyltransferases or gcn5-related n-acetyltransferases. a total of 11 of these coding sequences were also present in the genomes of other corynebacter ...201526149994
multidrug-resistant corynebacterium striatum bacteremia: first case in korea. 201526131424
urethritis due to corynebacterium striatum: an emerging germ.corynedbacterium striatum (cs) is a gram-positive coryneform bacillus that is part of mucous and skin flora. it has been considered as a causative agent of many infections in intensive care, neurology, traumatology and urology, but was never implicated in non-gonococcal urethritis. we report the case of a nosocomial urethritis due to corynebacterium striatum following resection of an intrameatus condyloma.201525955369
biofilm production by multiresistant corynebacterium striatum associated with nosocomial outbreak.corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. however, little is known about its virulence factors that may contribute to healthcare-associated infections (hais). we investigated the biofilm production on abiotic surfaces of multidrug-resistant (mdr) and multidrug-susceptible (mds) strains of c. striatum of pulsed-field gel electrophoresis types i-mdr, ii-mdr, iii-mds and iv-mds isolated during a nosocomial outbreak in rio de janeiro, brazil ...201525946249
antimicrobial activity of chemokine cxcl10 for dermal and oral microorganisms.cxcl10 (ip-10) is a small 10 kda chemokine with antimicrobial activity. it is induced by ifn-γ, chemoattracts mononuclear cells, and promotes adhesion of t cells. recently, we detected cxcl10 on the surface of the skin and in the oral cavity. in the current study, we used broth microdilution and radial diffusion assays to show that cxcl10 inhibits the growth of escherichia coli, staphylococcus aureus, corynebacterium jeikeium, corynebacterium striatum, and candida albicans hmv4c, but not coryneb ...201425859394
management of a patient with small-area burns, severe sepsis and superficial vein thrombosis.sepsis is frequently seen in severely burned patients, however it is not common in those with small-area burns. we present a case of a 22-year-old man suffering from a hot crush injury to his left hand dorsum covering 1% of his total body surface area. the patient developed severe sepsis and superficial vein thrombosis, probably due to wound infection. culture of the wound secretion indicated corynebacterium striatum. following intensive topical and systemic treatment the severe sepsis was contr ...201525647435
[drug susceptibility and homologous analysis on corynebacterium striatum strains isolated from inpatients].to explore the molecular epidemiological features and in vitro susceptibility profile of corynebacterium striatum strains isolated from different sites of inpatients, and further provide new data and idea for clinicians to better get knowledge of the clinical significance of corynebacterium striatum.201425410920
respiratory infection by corynebacterium striatum: epidemiological and clinical determinants.the increasing prevalence of advanced chronic respiratory disease, with frequent exposure to broad-spectrum antibiotics for repeated and prolonged hospitalizations, favours the emergence of nosocomial respiratory infection by gram-positive bacteria, such as outbreaks of corynebacterium striatum. there is little evidence about patterns of respiratory infection, transmission and adaptive ability of this pathogen. seventy-two c. striatum isolates from 51 advanced respiratory patients, mainly chroni ...201425356355
corynebacterium striatum: an emerging nosocomial pathogen in a case of laryngeal carcinoma.corynebacterium striatum is an emerging nosocomial pathogen associated with wound infections, pneumonia and meningitis. it is also a multidrug-resistant pathogen causing high morbidity. this is a report of an unusual case of wound infection in a patient with laryngeal carcinoma. accurate diagnosis of the infection and prompt management helped in a favourable outcome for the patient. this case highlights the role of c. striatum as an important nosocomial pathogen in immunocompromised patients.201425008830
rapid emergence of daptomycin resistance in clinical isolates of corynebacterium striatum… a cautionary tale.the objective of this study was to investigate the observation of daptomycin resistance in corynebacterium striatum, both in vivo and in vitro. we describe a case of c. striatum bacteremia in a patient with a left ventricular assist device (lvad); the initial isolate recovered was daptomycin susceptible with a minimum inhibitory concentration (mic) of 0.125 μg/ml. two months later, and after daptomycin therapy, the individual became bacteremic with an isolate of c. striatum with a daptomycin mic ...201424973133
extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines.chronic venous ulcer (cvu) represents a dreaded complication of chronic venous disease (cvd). the onset of infection may further delay the already precarious healing process in such lesions. some evidences have shown that matrix metalloproteinases (mmps) are involved and play a central role in both cvus and infectious diseases. two groups of patients were enrolled to evaluate the expression of mmps in infected ulcers and the levels of inflammatory cytokines as well as their prevalence. group i c ...201624618232
septic arthritis of a native knee joint due to corynebacterium striatum.we report a case of septic arthritis of a native knee joint due to corynebacterium striatum, a rare and unusual cause of septic arthritis of native joints. the isolate was identified by a combination of phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resistance to most antimicrobials.201424574280
multiple pulmonary nodules caused by corynebacterium striatum in an immunocompetent patient.nondiphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, however they rarely account for clinical infection. we present the first reported case of multiple pulmonary nodules caused by corynebacterium striatum. the infection occurred in a 72-year-old immunocompetent female, and the diagnosis was obtained by gram's stain and culture of lung biopsy. c. striatum should be recognized as a potential pathogen in both immunocompromised and nor ...201724553616
quadricuspid aortic valve complicated with infective endocarditis: report of a case.congenital quadricuspid aortic valve is a rare cardiac malformation with an unknown risk of infective endocarditis. we report a case of quadricuspid aortic valve complicated with infective endocarditis. a 53-year-old japanese woman was hospitalized with leg edema and a fever of unknown origin. corynebacterium striatum was detected in the blood culture. echocardiography demonstrated a quadricuspid aortic valve with vegetation and severe functional regurgitation. the condition was diagnosed as a q ...201424496979
corynebacterium striatum: an emerging nosocomial drug-resistant endocardial pathogen.endocarditis due to corynebacterium striatum has been rarely reported. a 78-year-old patient developed pacemaker endocarditis caused by multidrug-resistant c. striatum, complicated by vertebral osteomyelitis and epidural abscess. daptomycin therapy successfully eradicated the bacteremia and metastatic infection. a review of the english literature on this emerging nosocomial, multidrug-resistant pathogen is included.201324151771
[corynebacterium striatum]. 201323940879
septic arthritis of the shoulder due to corynebacterium striatum. 201323688845
epidemiological investigation of a nosocomial outbreak of multidrug-resistant corynebacterium striatum at one belgian university hospital.during an 8-month period, 24 corynebacterium striatum isolates recovered from lower respiratory tract specimens of 10 hospitalized patients were characterized. the organisms were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) and by 16s rrna gene sequencing. the cluster of c. striatum exclusively affected patients who had been admitted to an intensive care unit and/or subsequently transferred to one medium-size respiratory care unit. pro ...201423586637
clonal multidrug-resistant corynebacterium striatum within a nosocomial environment, rio de janeiro, brazil.corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. here, we document a nosocomial outbreak caused by multidrug-resistant (mdr) c. striatum in rio de janeiro, brazil. c. striatum identification was confirmed by 16s rrna and rpob gene sequencing. fifteen c. striatum strains were isolated from adults (half of whom were 50 years of age and older). c. striatum was mostly isolated in pure culture from tracheal aspirates of ...201323440110
about a bloodstream corynebacterium striatum isolate.corynebacterium striatum is often dismissed as a contaminant when cultivated from blood samples; indeed, it is a skin saprophyte that may therefore be introduced into the clinical specimen accidentally. nevertheless, the organism can be responsible for true bacteraemias, and multidrug resistance spread among nosocomial strains is of increasing concern. specific criteria for testing have not been defined yet, but we however suggest to report clear resistances (i.e. absence of any inhibition zones ...201323397249
non-diphtheriae corynebacterium species: an emerging respiratory pathogen.the purpose of the study was to describe the microbiological and clinical features of ten cases of lower respiratory tract infection due to corynebacterium striatum, corynebacterium propinquum and corynebacterium pseudodiphtheriticum. respiratory samples were recovered from hospitalised patients who were diagnosed of pneumonia and exacerbations of chronic respiratory infections. the samples were gram-stained and seeded on conventional bacterial growing media. bacteria were identified by matrix-a ...201223271676
sonication of explanted cardiac implants improves microbial detection in cardiac device infections.the sonication technique has been shown to be a promising tool for microbiological diagnosis of device-related infections. we evaluated the usefulness of the sonication method for pathogen detection in 80 explanted cardiac components collected from 40 patients, and the results were compared with those of conventional cultures. forty subjects undergoing cardiac device removal were studied: 20 had cardiac device infection, and 20 subjects underwent elective generator replacement or revision in the ...201323196364
comparison of the staphylococcus quickfish bc test with the tube coagulase test performed on positive blood cultures for evaluation and application in a clinical routine setting.many studies demonstrate that delayed proper therapy in bloodstream infections caused by staphylococcus aureus increases the mortality rate, emphasizing the need to shorten the turnaround time for positive blood cultures. different techniques are currently available, from phenotypic methods to more complex tests such as matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof), real-time pcr (rt-pcr), and fluorescence in situ hybridization using peptide nucleic aci ...201323100336
[etiology of ventilator-associated pneumonia at the cardiovascular surgery clinic of iaşi].we want to assess the etiology of ventilator-associated pneumonia (vap) and emergence of resistant phenotypes for greater efficiency of the first-line antimicrobial treatment post-cardiac surgery. the study focuses on patients with vap post-cardiac surgery at the institute of cardiovascular surgery between april 2nd 2002 and august 27th 2008, divided in two groups, before and after june 14th, 2005.201623077867
microbiological investigation and clinical significance of corynebacterium spp. in respiratory specimens.the purpose of this retrospective study was to evaluate the pathogenic role of corynebacterium species in lower respiratory tract infections as well as their routine laboratory investigation. from april 2007 to august 2009, 27 clinical isolates were significantly recovered from respiratory specimens of 27 different patients clinically suspected of having lower respiratory tract infections. the average age of patients was 65 years, while 22 (81%) patients presented at least 1 predisposing conditi ...201222938828
multidrug-resistant corynebacterium striatum endocarditis successfully treated with daptomycin. 201222817918
[a corynebacterium striatum endocarditis on a carrier of pacemaker].we report a new case of a corynebacterium striatum endocarditis on a carrier of a pacemaker. corynebacterium striatum was isolated from blood culture, the pulse generator and the pacing lead. a literature review of corynebacterium striatum endocarditis on a carrier of pacemaker was conducted.201222565181
identification and diversity of multiresistant corynebacterium striatum clinical isolates by maldi-tof mass spectrometry and by a multigene sequencing approach.the genus corynebacterium is composed of gram-positive bacteria that are widely distributed throughout the environment; these bacteria are also part of the normal microbiota of human skin and mucous membranes. multiple studies have shown that species of this genus, including c. striatum, become pathogenic to humans under special conditions. our aim was to determine the characteristics of clinical multiresistant strains of c. striatum that were isolated in our geographical region, to determine th ...201222475029
native valve endocarditis caused by corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?we describe a patient who developed corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant staphylococcus aureus bacteremia and osteomyelitis. the organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (mic of ≤ 0.094 μg/ml) and high-level resistance to daptomycin (mic of ≥ 256 μg/ml). the selection of daptomycin-resistant gram-positive skin flora ...201222450978
Antibacterial activity of sphingoid bases and fatty acids against gram-positive bacteria and gram-negative bacteria.There is growing evidence that the role of lipids in innate immunity is more important than previously realized. How lipids interact with bacteria to achieve a level of protection, however, is still poorly understood. To begin to address mechanisms of antibacterial activity, we determined minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of lipids common to the skin and oral cavity: sphingoid bases D-sphingosine, phytosphingosine, and dihydrosphingosine, and f ...201122155833
Corynebacterium striatum bacteremia associated with central venous catheter infection.Corynebacterium striatum (C striatum) has been considered a contaminant of blood culture in past decades. Here we report the case of a patient with acute deterioration of chronic renal failure. She received hemodialysis and died from C striatum bacteremia. By using a randomly amplified polymorphic DNA (RAPD) method, we found that an association existed between C striatum from the bloodstream and that from the central venous catheter. We suggest that C striatum could be a pathogen of bloodstream ...201122154992
enteral tube feeding alters the oral indigenous microbiota in elderly adults.enteral tube feeding is widely used to maintain nutrition for elderly adults with eating difficulties, but its long-term use alters the environment of the oral ecosystem. this study characterized the tongue microbiota of tube-fed elderly adults by analyzing the 16s rrna gene. the terminal restriction fragment length polymorphism (t-rflp) profiles of 44 tube-fed subjects were compared with those of 54 subjects fed orally (average age 86.4 -¦ 6.9 years). barcoded pyrosequencing data were also obta ...201121821752
[corynebacterium striatum pneumonia in an hiv patient.] 201121477896
[recurrent corynebacterium striatum endocarditis, secondary to osteomyelitis]. 201021195570
pacemaker lead endocarditis due to multidrug-resistant corynebacterium striatum detected with sonication of the device.corynebacterium striatum is a commensal of human skin and has been recently recognized as an emerging pathogen. a case of nosocomial pacemaker lead endocarditis due to a multidrug-resistant c. striatum strain is described, highlighting the role of sonication as a diagnostic tool in cardiac device infections.201020943861
corynebacterium striatum as an emerging pathogen. 201020688419
surface bacteriology of venous leg ulcers and healing outcome.bacteria can be cultured from all venous leg ulcers (vlus) regardless of healing status, and the significance of a positive swab result in non-clinically infected ulcers is unknown. the aim of this study was to characterise the bacteriological flora of vlus by routine culture to determine whether the data generated had prognostic value.201020671048
high frequency of macrolide resistance mechanisms in clinical isolates of corynebacterium species.the genus corynebacterium includes a high number of species that are usually isolated from human skin as saprophytes. however, these microorganisms have also been reported as infectious agents in a broad group of patients and have showed broad-spectrum resistance. we studied the susceptibility profiles against macrolides, clindamycin, and streptogramins of 254 clinical strains belonging to the species corynebacterium urealyticum (120), corynebacterium amycolatum (66), corynebacterium jeikeium (1 ...201020624090
[cystitis and haematuria due to corynebacterium striatum. a case report and review].we herewith report the first case of uncomplicated urinary tract infection due to corynebacterium striatum in an ambulatory patient without any other predisponent risk factors. c. striatum is a ubiquitous saprophyte of human skin and mucous membranes, which has been occasionally associated with infection in patients hospitalized or immunocompromised patients with underlying diseases. we conclude that c. striatum should be considered an emerging pathogen in both immunocompetent and immunocompromi ...200919900386
international external quality assurance for laboratory diagnosis of diphtheria.the diphtheria surveillance network (dipnet) encompassing national diphtheria reference centers from 25 european countries is a dedicated surveillance network recognized by the european commission. a key dipnet objective is the quality assessment of microbiological procedures for diphtheria across the european union and beyond. a detailed questionnaire on the level of reference laboratory services and an external quality assessment (eqa) panel comprising six simulated throat specimens were sent ...200919828749
corynebacterium striatum--a classic pathogen eluding diagnosis.we report one case of infective endocarditis and two cases of arthritis due to corynebacterium striatum. after reviewing all previously reported cases, we illustrate the clinical features typical of infection, including nosocomial risk factors and prominent embolic phenomena in the cases of endocarditis. our cases underscore the importance of prompt diagnosis when confronted with positive blood and synovial cultures. this ubiquitous organism and common contaminant is a rare yet deadly pathogen.200919393478
corynebacterium striatum infecting a malignant cutaneous lesion: the emergence of an opportunistic pathogen.we described a case of a 27-year old male patient with skin and soft tissue infection of a neoplastic lesion caused by corynebacterium striatum, an organism which has been rarely described as a human pathogen. identification was confirmed by dna sequencing. successful treatment with penicillin was achieved. the role of the c. striatum as an emerging opportunistic pathogen is discussed.200919390742
in vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus corynebacterium.we studied the in vitro activity of tigecycline and 10 other commonly used antibiotics against 135 clinical isolates of non-diphtheria corynebacterium spp. using the etest system. tigecycline minimum inhibitory concentrations for 50% and 90% of the organisms (mic(50) and mic(90) values, respectively, in mg/l) were: corynebacterium urealyticum, 0.094 and 0.125; corynebacterium amycolatum, 0.125 and 2; corynebacterium jeikeium, 0.094 and 0.75; corynebacterium coyleae, 0.064 and 0.064; corynebacter ...200919153032
clonal multidrug-resistant corynebacterium striatum strains, italy.we assessed the clinical relevance and performed molecular characterization of 36 multidrug-resistant strains of corynebacterium striatum. pulsed-field gel electrophoresis confirmed a single clone, possessing erm(x), teta/b, cmxa/b, and apha1 genes, but few related subclones. this strain is emerging as a pathogen in italy.200919116057
nosocomial valve endocarditis due to corynebacterium striatum: a case report.abstract: staphylococcus aureus, coagulase-negative staphylococci, and enterococci sp. are the usual pathogens involved in nosocomial bacterial endocarditis. corynebacterium species isolation in blood specimens is usually considered to be a contaminant. we present an interesting case of native mitral valve endocarditis in a 73 year old african american female that was diagnosed days after she was discharged from our institution. the infection was cleared with medical therapy alone.200819077258
multicenter evaluation of the vitek 2 anaerobe and corynebacterium identification card.the new anaerobe and corynebacterium (anc) identification card for vitek 2 was compared with a 16s rrna gene sequencing (16s) reference method for accuracy in the identification of corynebacteria and anaerobic species. testing was performed on a vitek 2 xl system with modified software at three clinical trial laboratories. reproducibility was determined with nine atcc quality control strains that were tested 20 times over a minimum of 10 days at all three sites. a challenge set of 50 well-charac ...200818562580
isolation of a bacterial enzyme releasing axillary malodor and its use as a screening target for novel deodorant formulations.axillary odor is known since 50 years to be formed upon the action of corynebacteria on odorless axilla secretions, but the nature of the bacterial enzymes involved in this process remained a mystery. we identified the known axilla odor determinant 3-methyl-2-hexenoic acid in hydrolyzed axilla secretions along with a new, chemically related compound, 3-hydroxy-3-methyl-hexanoic acid. the natural, odorless precursors of both these acids were purified from non-hydrolyzed fresh axilla secretions. t ...200518492161
resistance determinant erm(x) is borne by transposon tn5432 in bifidobacterium thermophilum and bifidobacterium animalis subsp. lactis.the erm(x) gene from erythromycin- and clindamycin-resistant bifidobacterium strains was characterised by polymerase chain reaction and sequence analysis, including flanking regions. results suggest that the resistance determinant was part of transposon tn5432 that has been described in several opportunistic pathogens such as corynebacterium striatum and propionibacterium acnes.200818378122
an unusual case of corynebacterium striatum endocarditis and a review of the literature. 200818346922
activity of tigecycline against coryneform bacteria of clinical interest and listeria monocytogenes.the activities of tigecycline and eight other agents were evaluated against 220 coryneform bacteria and 42 listeria monocytogenes isolates. all strains were inhibited by tigecycline at 0.5 mug/ml, except for 11 corynebacterium striatum strains that were inhibited at 1 mug/ml. tigecycline shows good in vitro activity against coryneform bacteria and l. monocytogenes.200818227183
infections caused by coryneform bacteria in pediatric oncology patients.invasive infections caused by coryneform bacteria are uncommon but have been reported with increasing frequency in recent decades, especially in immunocompromised persons. because pediatric experience is limited, we examined the epidemiology and clinical characteristics of these infections in children undergoing cancer therapy.200818174873
outbreak of multi-resistant corynebacterium striatum infection in an italian general intensive care unit. 200717719684
arthritis caused by corynebacterium striatum: spontaneous infection? 200717548460
nosocomial outbreak of corynebacterium striatum infection in patients with chronic obstructive pulmonary disease.we describe an unusual cluster of corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (copd) admitted to a medium-size respiratory unit. eleven isolates from eight patients occurred simultaneously within a month. c. striatum is a potentially pathogenic microorganism with the ability to produce nosocomial infectious outbreaks and respiratory colonization in patients with advanced copd.200717409213
[evaluation of api coryne system, version 2.0, for diphteroid gram-positive rods identification with clinical relevance].the ability of the api coryne system, version 2.0, to identify 178 strains of gram-positive rods was evaluated. seventy eight isolates belonged to genus corynebacterium and one hundred to related genera, all strains were isolated from clinical samples at the laboratory of bacteriology, hospital de clínicas josé de san martin (uba) between 1995 and 2004. the isolates were identified according to von graevenitz and funke's scheme. one hundred and sixty two out of 178 strains (91%) were correctly i ...200617370571
molecular diagnosis of native mitral valve endocarditis due to corynebacterium striatum. 200617201210
identification of odoriferous sulfanylalkanols in human axilla secretions and their formation through cleavage of cysteine precursors by a c-s lyase isolated from axilla bacteria.human axillary odor is known to be formed upon the action of corynebacteria sp. on per se odorless axilla secretions. besides the known odoriferous acids, we report the occurrence in human axilla secretions of four odoriferous sulfanylalkanols, namely 3-sulfanylhexan-1-ol (3), 2-methyl-3-sulfanylbutan-1-ol (4), 3-sulfanylpentan-1-ol (5), and 3-methyl-3-sulfanylhexan-1-ol (6). these compounds have a pungent sweat/kitchen odor, also reminiscent of onions with some fruity connotations, and percepti ...200417191898
a spontaneous joint infection with corynebacterium striatum.corynebacterium striatum is a ubiquitous saprophyte with the potential to cause bacteremia in immunocompromised patients. until now, spontaneous infection of a natural joint has not been reported. when phenotyping failed, gene sequencing was used to identify the species. the isolate demonstrated high-level resistance to most antibiotics.200717151206
identification of the emerging skin pathogen corynebacterium amycolatum using pcr-amplification of the essential diviva gene as a target.the actinomycete corynebacterium amycolatum is a saprophytic bacterium usually associated with the human skin, but it is at present considered an emergent pathogen as it is isolated from nosocomial settings from samples of immunosuppressed patients. the conventional method to distinguish c. amycolatum from closely related species is mainly based on phenotypic or chemotaxonomic studies. we developed a molecular method to identify rapidly c. amycolatum based on the use of different primers for amp ...200617147766
emergence of multidrug-resistant corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with underlying diseases.during a 53-month period (march 1994 to august 1998), 48 corynebacterium striatum isolates recovered from clinical specimens were characterized. the organisms were identified by both phenotypic characteristics and 16s rrna gene sequence analysis. thirty-six (75%) were isolated from sputum/bronchial aspirates, 10 (21%) from wound exudates/pus, 1 (2%) from vaginal discharge, and 1 (2%) from an otorrheic specimen. all 48 patients had been hospitalized for treatment of an underlying disease and had ...200616406181
first report of prosthetic mitral valve endocarditis due to corynebacterium striatum: successful medical treatment. case report and literature review.a rare case of prosthetic mitral valve endocarditis due to corynebacterium striatum, treated medically, is reported. while this organism has been described in a few cases of native valve endocarditis, only two cases of prosthetic aortic valve endocarditis have been reported. we herewith report the first case of successful medical treatment of prosthetic mitral valve endocarditis due to c. striatum, emphasizing the complicated clinical course and reviewing the literature regarding diagnosis and t ...200616236359
successful treatment of corynebacterium striatum endocarditis with daptomycin plus rifampin.to report a case of corynebacterium striatum endocarditis that was treated successfully with daptomycin plus rifampin following an unsuccessful attempt at vancomycin desensitization and failure of linezolid therapy.200516144879
relationship between mutations in the gyra gene and quinolone resistance in clinical isolates of corynebacterium striatum and corynebacterium amycolatum.quinolone susceptibility was analyzed in 17 clinical isolates of corynebacterium striatum and 9 strains of corynebacterium amycolatum by the e-test method in mueller-hinton agar plates. the c. striatum atcc 6940 strain was used as a control strain. the amplified quinolone resistance determining regions of the gyra genes of c. amycolatum and c. striatum were characterized. four in vitro quinolone-resistant mutants of c. amycolatum were selected and analyzed. both in vivo and in vitro quinolone-re ...200515855486
corynebacterium striatum: an underappreciated community and nosocomial pathogen.corynebacterium striatum (cs) is an underappreciated human pathogen that has been associated with serious infections in both immunocompetent and immunocompromised hosts. cs infections tend to be more frequent in males and major infection sites have included blood stream, lung, and central nervous system. most are nosocomially acquired and there is a significant association with medical devices ranging from intravascular catheters to central nervous system drainage devices. empiric therapy with v ...200515845432
corynebacterium striatum endocarditis masquerading as connective tissue disorders. 200415598704
impact of manufacturing, irradiation and filtration steps to bacterial contamination of autologous fibrin sealant.preoperative production of autologous fibrin sealant has become a routine procedure during the last years. as a certain percentage of blood products is contaminated with bacteria, contamination of plasma used for the production of fibrin sealant cannot be excluded. especially in the orthopaedic setting, application of contaminated fibrin sealant can cause severe infections.200415536048
exit-site infections by non-diphtheria corynebacteria in capd.non-diphtheria corynebacteria species cause disease in risk populations such as immunocompromised patients and patients with indwelling medical devices. despite reports of exit-site infection and peritonitis caused by non-diphtheria corynebacteria, these organisms are frequently dismissed as contaminants. during a 10-year observation period, we prospectively identified 8 cases of exit-site/tunnel infections caused by 2 different species of corynebacteria (corynebacterium striatum in 5 and c. jei ...200415490985
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