Publications

human papillomavirus 6a lesions of the lower eyelid and genitalia.	a 42-year-old white man presented with a lower eyelid lesion and recurrent condylomata acuminata of his genitalia due to human papillomavirus (hpv) type 6a. polymerase chain reaction analysis of both lesions was performed. the eyelid lesion was excised and found to be a papilloma caused by hpv6a infection. an extensive literature search revealed one previous report of concurrent conjunctival papilloma and genital papilloma involving hpv6a. rare cases of solitary lesions of the eyelid secondary t ...	2006	16855513
refined physical map of the human pax2/hox11/nfkb2 cancer gene region at 10q24 and relocalization of the hpv6ai1 viral integration site to 14q13.3-q21.1.	chromosome band 10q24 is a gene-rich domain and host to a number of cancer, developmental, and neurological genes. recurring translocations, deletions and mutations involving this chromosome band have been observed in different human cancers and other disease conditions, but the precise identification of breakpoint sites, and detailed characterization of the genetic basis and mechanisms which underlie many of these rearrangements has yet to be resolved. towards this end it is vital to establish ...	2003	12697057
cell-type-specific separate regulation of the e6 and e7 promoters of human papillomavirus type 6a by the viral transcription factor e2.	gene expression of human papillomaviruses (hpv) is tightly controlled by cellular factors and by the virally encoded e2 protein through binding to distinct sites within the regulatory noncoding region. while for the high-risk genital papillomaviruses a single promoter drives the expression of all early genes, a second promoter present in the e6 open reading frame of the low-risk hpv type 6 (hpv6) would allow an independent regulation of e6 and e7 oncogene expression. in this report, we provide t ...	1997	9261424
expression of the major capsid protein of human papillomavirus type 11 in saccharomyces cerevisae.	the major capsid protein l1 of papillomaviruses expressed recombinantly or in infected cells has the intrinsic ability to form virus-like particles (vlps) which display conformational epitopes necessary to elicit high-titered, virus-neutralizing antibodies. we have shown previously that the l1 gene of human papillomavirus type 6a (hpv6) can be expressed efficiently in saccharomyces cerevisae (sc) as vlps. however, when we attempted to express the l1 gene cloned from the closely related hpv11 in ...	1996	8973339
deletion in the l1 open reading frame of human papillomavirus type 6a genomes associated with recurrent laryngeal papilloma.	human papillomavirus (hpv) type 6a genomes with a large deletion in their l1 open reading frames (orf) were found in two of five recurrent cases of laryngeal papilloma. one of these mutant hpvs had a 186 base pair (bp) deletion near the n-terminus end of the l1 orf, which encodes a major capsid protein. the other had a 454 bp deletion at the c-terminus end of l1 at which is located a nuclear localising signal (nls). no other large deletion or insertion was found in the remaining regions of all f ...	1995	8551268
integration of human papillomavirus type 6a dna in a tonsillar carcinoma: chromosomal localization and nucleotide sequence of the genomic target region.	human papillomavirus type 6a (hpv 6a) dna was detected in a tonsillar carcinoma both as integrated and episomal molecules, and one viral-cellular junction was molecularly cloned (bercovich et al., j. gen virol., 72: 2569-2572, 1991). the cellular sequence was used as a probe for the isolation of a cosmid from a normal human genomic dna library. a 2.7-kilobase subclone including the integration site was sequenced. it was shown to contain sequences with similarities to the e2 and l2 regions of hum ...	1994	8118820
sequence variation in the extreme 5' end of the human papillomavirus type 6a long control region.	a sequence analysis of human papillomavirus (hpv) type 6a isolates from 15 exophytic condylomata acuminata lesions was done to determine the prototype sequence for this region of hpv 6a, which sequences are conserved and which vary, and whether the variability might be useful in epidemiologic studies. the long control region (lcr) was amplified by the polymerase chain reaction and approximately 242 bp were directly sequenced. the data indicate that all isolates contain a 94-bp insertion relative ...	1995	7876621
sequence determination of human papillomavirus type 6a and assembly of virus-like particles in saccharomyces cerevisiae.	human papillomavirus 6a (hpv6a), the most abundant hpv6 subtype, was detected in a vulvar condyloma acuminatum. the complete genome of hpv6a was cloned, and its dna sequence was shown to be over 97% identical to the hpv6b sequence. of the eight open reading frames (orfs) of hpv6a, only the imputed amino acid sequence of the major capsid protein l1 was identical to the corresponding hpv6b sequence; all other hpv6a orfs showed amino acid changes compared to the hpv6b orfs. the hpv6a l1 or the l1 + ...	1995	7778283
human papillomavirus type 6a dna in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication.	transcriptionally active human papillomavirus type 6a (hpv-6a) dna was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. the carcinoma contained episomal hpv-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. hpv-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. a role for the mutant molecules in the pathogenesis of the malignancy is suggeste ...	1992	1311363