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bovine papillomavirus e2 protein activates a complex growth-inhibitory program in p53-negative ht-3 cervical carcinoma cells that includes repression of cyclin a and cdc25a phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein.the bovine papillomavirus e2 protein can inhibit the proliferation of ht-3 cells, a p53-negative cervical carcinoma cell line containing integrated human papillomavirus type 30 dna. here, we analyzed ht-3 cells to explore the mechanism of p53-independent e2-mediated growth inhibition. expression of the e2 protein repressed expression of the endogenous human papillomavirus type 30 e6/e7 genes. this was accompanied by hypophosphorylation and increased accumulation of p105rb and repression of e2f1 ...199910392903
human papillomavirus type 53.the cloning and partial characterization of the genome of human papillomavirus type 53 is presented. the virus is a distinct type and is most closely related to human papillomavirus type 30.19892552169
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