Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| antiprotozoal activity of extracts of elaeodendron trichotomum (celastraceae). | chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in latin america. the drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. the present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of elaeodendron trichotomum, a celastraceus, that is used in mexico as an anti-infective in febrile-type diseases. | 2016 | 28852732 |
| risk of bacterial vaginosis, trichomonas vaginalis and candida albicans infection among new users of combined hormonal contraception vs lng-ius. | the study assessed the risk of bacterial vaginosis, trichomonas vaginalis and candida albicans infection among new users of either a combined oral contraceptive pill (coc) or the levonorgestrel-releasing intrauterine system (lng-ius). | 2017 | 28849960 |
| role of α-actinin 2 in cytoadherence and cytotoxicity of trichomonas vaginalis. | trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. t. vaginalis α-actinin 2 (tvα-actinin 2), has been used to diagnose trichomoniasis. tvα-actinin 2 was dissected into three parts, the n-terminal, central, and c-terminal portions of the protein (#1, #2, and #3, respectively). western blot of these tvα-actinin 2 proteins with pooled patients' sera indicated that tvα-actinin 2 #2 and #3, but not tvα-actinin 2 #1, reacted with those sera. immunofluorescence assays o ... | 2017 | 28838225 |
| cryo-em structures of the 80s ribosomes from human parasites trichomonas vaginalis and toxoplasma gondii. | as an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. high-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. with cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, trichomonas vaginalis ... | 2017 | 28809395 |
| parents' and teachers' views on sexual health education and screening for sexually transmitted infections among in-school adolescent girls in kenya: a qualitative study. | to successfully develop and implement school-based sexual health interventions for adolescent girls, such as screening for chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis, it is important to understand parents' and teachers' attitudes towards sexual health education and acceptability of sexually transmitted infection (sti) screening interventions. | 2017 | 28806985 |
| vaginal infections in haitian immigrant women living in miami, florida. | to characterize vulvovaginal candidiasis (vc), trichomonas vaginalis (tv), and bacterial vaginosis (bv) among haitian women living in miami to identify contributing factors to cervical cancer disparity in this population. | 2017 | 28804083 |
| the detection of microorganisms related to urethritis from the oral cavity of male patients with urethritis. | to investigate the presence of microorganisms related to urethritis in the oral cavity of male patients with urethritis and the efficacies of antimicrobials for urethritis on microorganisms in the oral cavity. | 2017 | 28803864 |
| a competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase. | the protozoan parasite trichomonas vaginalis contains two nearly identical triosephosphate isomerases (tvtims) that dissociate into stable monomers and dimerize upon substrate binding. herein, we compare the role of the "ball and socket" and loop 3 interactions in substrate assisted dimer assembly in both tvtims. we found that point mutants at the "ball" are only 39 and 29-fold less catalytically active than their corresponding wild-type counterparts, whereas loop 3 deletions are 1502 and 9400-f ... | 2017 | 28803140 |
| high prevalence of asymptomatic sexually transmitted infections among human immunodeficiency virus-infected pregnant women in a low-income south african community. | there is a lack of evidence on the burden of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) among hiv-infected pregnant women in south africa. we conducted a cross-sectional analysis of hiv-infected pregnant women in two healthcare facilities in a south african township to determine the prevalence of ct, ng and tv. hiv-infected pregnant women were recruited during the first antenatal care visit for their current pregnancy and requested to self-collect vulvo ... | 2017 | 28799824 |
| cross-sectional study to evaluate trichomonas vaginalis positivity in women tested for neisseria gonorrhoeae and chlamydia trachomatis, attending genitourinary medicine and primary care clinics in bristol, south west england. | highly sensitive, commercial nucleic acid amplification tests (naat) for trichomonas vaginalis have only recently been recommended for use in the uk. while testing for t. vaginalis is routine in symptomatic women attending genitourinary medicine (gum) clinics, it is rare in asymptomatic women or those attending primary care. the aim of this study was to evaluate the positivity of t. vaginalis using a commercial naat, in symptomatic and asymptomatic women undergoing testing for chlamydia and gono ... | 2017 | 28798195 |
| prevalence and impact of sexually transmitted infections in pregnant women in central ethiopia. | human immunodeficiency virus (hiv) continues to be a major global public health issue and omnipresent sexually transmitted infections (stis) increase the risk of hiv acquisition. moreover, stis and hiv in pregnant women can harm the unborn child. in this study, we systematically investigated the prevalence of hiv, relevant stis and vaginal group b streptococcus colonization among pregnant women presenting at asella teaching hospital in central ethiopia and their effect on perinatal mortality. a ... | 2017 | 28776463 |
| demographic and behavioural risk factors associated with trichomonas vaginalis among south african hiv-positive men with genital ulcer disease: a cross-sectional study. | demographic and risky sexual behaviours may increase the risk for trichomonas vaginalis (tv) infection and, thus, enhance hiv transmission to uninfected partners. we assessed the demographic and behavioural risk factors associated with tv among south african hiv-positive men with genital ulcer disease. | 2017 | 28765124 |
| considerable genetic diversity of trichomonas vaginalis clinical isolates in a targeted population in south of iran. | the present study aimed to characterize genetically and to compare the most frequently occurring strains of trichomonas vaginalis isolated from southern iran. | 2017 | 28761486 |
| genotyping, drug susceptibility and prevalence survey of trichomonas vaginalis among women attending gynecology clinics in hamadan, western iran, in 2014-2015. | in spite of sufficient knowledge about phenotypic variation of trichomonas vaginalis, its genetic characteristics are poorly understood. we carried out a molecular epidemiology study in which in vitro metronidazole susceptibility of t. vaginalis isolates was considered. | 2017 | 28761458 |
| therapeutic effects of iranian herbal extracts against trichomonas vaginalis | trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are fda approved drugs recommended for trichomoniasis treatment. treatment with metronidazole 5'-nitroimidazole derivatives is associated with many side effects, and drug resistance to metronidazole has been reported in some cases. rec ... | 2017 | 28755655 |
| results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria. | urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. the objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction ... | 2017 | 28735999 |
| genome-wide identification, in silico characterization and expression analysis of zip-like genes from trichomonas vaginalis in response to zinc and iron. | trace elements such as zinc and iron are essential components of metalloproteins and serve as cofactors or structural elements for enzymes involved in several important biological processes in almost all organisms. because either excess or insufficient levels of zn and fe can be harmful for the cells, the homeostatic levels of these trace minerals must be tightly regulated. the zinc regulated transporter, iron regulated transporter-like proteins (zip) comprise a diverse family, with several para ... | 2017 | 28733845 |
| sexually transmitted disease and male infertility: a systematic review. | theoretically, sexually transmitted diseases (stds) have the potential to disrupt male fertility; however, the topic remains controversial. | 2016 | 28723470 |
| antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes. | isonicotinyl and pyrazinyl ferrocenyl-derived complexes were prepared using various hydrazides and ferrocenyl aldehydes. three heterobimetallic complexes were also synthesized from the schiff base-derived isonicotinyl ferrocene complex using various platinum group metal dimers based on ruthenium, rhodium and iridium. all complexes were evaluated in vitro for antimycobacterial and antiparasitic activity. against mycobacterium tuberculosis h37rv, the platinum group metal complexes showed glycerol- ... | 2017 | 28713884 |
| urinary meatal swabbing detects more men infected with mycoplasma genitalium and four other sexually transmitted infections than first catch urine. | urinary meatal swabs compared with urine showed higher infection rates for mycoplasma genitalium (15.3% vs 12.6%, p = 0.035), chlamydia trachomatis (11.3% vs 9.3%, p = 0.039), neisseria gonorrhoeae (1.4% vs 1.1%, p = 1.00), trichomonas vaginalis (8.0% vs 1.7%, p < 0.001), and high-risk human papillomavirus (5.9% vs 3.4%, p = 0.078) respectively. | 2017 | 28703728 |
| detecting the diversity of mycoplasma and ureaplasma endosymbionts hosted by trichomonas vaginalis isolates. | objectives: the symbiosis of trichomonas vaginalis and mycoplasma hominis is the first described association between two obligate human parasites. trichomonas is the niche and the vector for the transmission of m. hominis infection. this clinically significant symbiosis may affect t. vaginalis virulence and susceptibility to treatment. the aims of this study were to investigate the intracellularly present mycoplasma and ureaplasma species in t. vaginalis strains isolated from the vaginal dischar ... | 2017 | 28702014 |
| aetiological agents of vaginitis in nigerian women. | this study focuses on the identification of aetiological agents of vaginitis in nigerian women. study subjects are drawn from patients presenting with lower abdominal pain, vaginal discharge and itching at the gynaecology clinic of lagos university teaching hospital and at the clinical centre of the nigerian institute of medical research, yaba, lagos, between january 2001 and july 2002. a total of 250 patients gave informed consent to participate in the study. the patients also had pre- and post ... | 2004 | 28696900 |
| rapid and point-of-care tests for the diagnosis of trichomonas vaginalis in women and men. | trichomonasvaginalis (tv) is a highly prevalent parasitic infection worldwide. it is associated with many adverse reproductive health outcomes. many infections are asymptomatic and syndromic management leads to underdetection of tv. traditional methods of tv detection such as wet preparation are insensitive. new rapid, point-of-care (poc) tests can enhance the diagnosis of trichomoniasis. | 2017 | 28684611 |
| very low sensitivity of wet mount microscopy compared to pcr against culture in the diagnosis of vaginal trichomoniasis in uganda: a cross sectional study. | trichomonas vaginalis (tv) causes the trichomoniasis syndrome composed of vaginitis in women, urethritis in men and tube infection in both sexes. this infection is strongly associated with premature rupture of membranes, preterm delivery, low birth weight, promoting hiv sexual transmission and infertility. prevention of these complications requires accurate early detection and effective treatment of infected individuals. in the resource limited settings, the wet mount microscopy (wmm) is often t ... | 2017 | 28683790 |
| trichomonas vaginalis is rare among women in iceland. | 2017 | 28681060 | |
| polyamine transport and synthesis in trichomonas vaginalis: potential therapeutic targets. | polyamines are essential for many biological processes in all organisms. here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. this review focused on the synthesis, interconversion and function of these molecules in trichomonas vaginalis, a common sexually transmitted parasit ... | 2017 | 28671057 |
| trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race/ethnicity in the plco trial. | results from previous sero-epidemiologic studies of trichomonas vaginalis infection and prostate cancer (pca) support a positive association between this sexually transmitted infection and aggressive pca. however, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between t. vaginalis seropositivity and pca in african-american men who are at highest risk of both infection and pca. therefore, we examined this possible relation in the pr ... | 2017 | 28669054 |
| antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. | the 7-benzylidenenaltrexone (bntx) derivatives 2a-v, 3a-c, 13a-c, and 14a were synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. the structure-activity-relationship studies found that 4-iodo-bntx (2g) showed the highest activity (ic50=10.5µm) and the affinity for the opioid receptor was less important for antitrichomonal activity against trichomonas vaginalis. the morphinan skeleton bearing both the double bond for a michael acceptor and the phenolic hydroxy group ... | 2017 | 28662966 |
| primary health clinic toilet/bathroom surface swab sampling can indicate community profile of sexually transmitted infections. | the microbiome of built environment surfaces is impacted by the presence of humans. in this study, we tested the hypothesis that analysis of surface swabs from clinic toilet/bathroom yields results correlated with sexually transmitted infection (sti) notifications from corresponding human populations. we extended a previously reported study in which surfaces in toilet/bathroom facilities in primary health clinics in the australian northern territory (nt) were swabbed then tested for nucleic acid ... | 2017 | 28652937 |
| synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-nsaid chimeras displaying broad antiprotozoal spectrum. | we designed and synthesized five new 5-nitrothiazole-nsaid chimeras as analogues of nitazoxanide, using a dcc-activated amidation. compounds 1-5 were tested in vitro against a panel of five protozoa: 2 amitochondriates (giardia intestinalis, trichomonas vaginalis) and 3 kinetoplastids (leishmania mexicana, leishmania amazonensis and trypanosoma cruzi). all chimeras showed broad spectrum and potent antiprotozoal activities, with ic50 values ranging from the low micromolar to nanomolar order. comp ... | 2017 | 28645659 |
| ureaplasma urealyticum and u. parvum in sexually active women attending public health clinics in brazil. | ureaplasma urealyticum and u. parvum have been associated with genital infections. the purpose of this study was to detect the presence of ureaplasmas and other sexually transmitted infections in sexually active women from brazil and relate these data to demographic and sexual health, and cytokines il-6 and il-1β. samples of cervical swab of 302 women were examined at the family health units in vitória da conquista. the frequency of detection by conventional pcr was 76·2% for mollicutes. in qpcr ... | 2017 | 28637523 |
| prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey. | background papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown. | 2016 | 28636866 |
| genetic indicators of drug resistance in the highly repetitive genome of trichomonas vaginalis. | trichomonas vaginalis, the most common nonviral sexually transmitted parasite, causes ∼283 million trichomoniasis infections annually and is associated with pregnancy complications and increased risk of hiv-1 acquisition. the antimicrobial drug metronidazole is used for treatment, but in a fraction of clinical cases, the parasites can become resistant to this drug. we undertook sequencing of multiple clinical isolates and lab derived lines to identify genetic markers and mechanisms of metronidaz ... | 2017 | 28633446 |
| sexually transmitted infections: a novel screening strategy for improving women's health in vulnerable populations. | migrant women are one of the most vulnerable population to health problems and well-being. this study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (stis) in undocumented migrant women in milan, italy. | 2017 | 28632191 |
| candidatus mycoplasma girerdii replicates, diversifies, and co-occurs with trichomonas vaginalis in the oral cavity of a premature infant. | genital mycoplasmas, which can be vertically transmitted, have been implicated in preterm birth, neonatal infections, and chronic lung disease of prematurity. our prior work uncovered 16s rrna genes belonging to a novel, as-yet-uncultivated mycoplasma (lineage 'mnola') in the oral cavity of a premature neonate. here, we characterize the organism's associated community, growth status, metabolic potential, and population diversity. sequencing of genomic dna from the infant's saliva yielded 1.44 gb ... | 2017 | 28630471 |
| audit of trichomonas vaginalis test requesting by community referrers after a change from culture to molecular testing, including a cost analysis. | trichomonas vaginalis (tv) prevalence varies among different communities and peoples. the availability of robust molecular platforms for the detection of tv has advanced diagnosis; however, molecular tests are more costly than phenotypic methodologies, and testing all urogenital samples is costly. we recently replaced culture methods with the aptima trichomonas vaginalis nucleic acid amplification test on specific request and as reflex testing by the laboratory, and have audited this change. | 2017 | 28617786 |
| trichomonas vaginalis is very rare among women with vaginal discharge in podlaskie province, poland. | trichomonas vaginalis is the most common curable sexually transmitted pathogen globally. however, in the european union (eu), trichomoniasis appears to be a rare condition. the aim of this study was to examine the prevalence of t. vaginalis among females attending an sti centre in bialystok, poland, using the highly sensitive and specific aptima t. vaginalis assay. consecutive females, referred by gynaecologists mainly because of abnormal vaginal discharge, were diagnosed using wet mount microsc ... | 2017 | 28612378 |
| unique trichomonas vaginalis gene sequences identified in multinational regions of northwest china. | trichomonas vaginalis (t. vaginalis) is a flagellated protozoan parasite that infects humans worldwide. this study determined the sequence of the 18s ribosomal rna gene of t. vaginalis infecting both females and males in xinjiang, china. samples from 73 females and 28 males were collected and confirmed for infection with t. vaginalis, a total of 110 sequences were identified when the t. vaginalis 18s ribosomal rna gene was sequenced. these sequences were used to prepare a phylogenetic network. t ... | 2017 | 28603223 |
| the fluorescent protein ilov outperforms egfp as a reporter gene in the microaerophilic protozoan trichomonas vaginalis. | trichomonas vaginalis is a flagellated protozoan causing a notorious urogenital infection in humans. due to its anaerobic metabolism, an alternative fluorescent protein that can be readily expressed in oxygen-deprived conditions is ideal. this study assessed the performance of ilov, which does not require oxygen to function, as compared to the conventional enhanced green fluorescent protein (egfp) in t. vaginalis. the results indicated that ilov outperforms egfp in both transient and stable expr ... | 2017 | 28602728 |
| burden and characteristics of hiv infection among female sex workers in kampala, uganda - a respondent-driven sampling survey. | sex workers in uganda are at significant risk for hiv infection. we characterized the hiv epidemic among kampala female sex workers (fsw). | 2017 | 28601086 |
| synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives: identification of new selective giardicidal and trichomonicidal compounds. | a series of twelve new 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives (1-12) were synthesized and their antiparasitic activity was tested in vitro against giardia intestinalis, trichomonas vaginalis and entamoeba histolytica. experimental evaluations showed ic50 values within the nanomolar range for all tested compounds, some showing higher activity than metronidazole and albendazole. a chemoinformatic study was used to compare the structure-activity relationship of the synthesized ca ... | 2017 | 28595066 |
| potential of synthetic endoperoxides against trichomonas vaginalis in vitro. | metronidazole is well known for medicine against trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. here, we noticed the killing effects of endoperoxide compounds, n-89 and n-251 as new antimalarial drug candidates, on t. vaginalis and searched the possibility of development of new medicine. we added each of metronidazole, artemisinin, ... | 2017 | 28571765 |
| c-reactive protein is differentially modulated by co-existing infections, vitamin deficiencies and maternal factors in pregnant and lactating indigenous panamanian women. | the usefulness of c-reactive protein (crp) as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common. | 2017 | 28571565 |
| prevalence and risk factors associated with sexually transmitted infections (stis) among women of reproductive age in swaziland. | sexually transmitted infections (stis) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. epidemiological data on stis among women of reproductive age in swaziland are limited. the availability of epidemiological data on stis and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. the study aimed to determine the prevale ... | 2017 | 28559923 |
| strategies for prevention and treatment of trichomonas vaginalis infections. | the last estimated annual incidence of trichomonas vaginalis worldwide exceeds that of chlamydia and gonorrhea combined. this critical review updates the state of the art on advances in t. vaginalis diagnostics and strategies for treatment and prevention of trichomoniasis. in particular, new data on treatment outcomes for topical administration of formulations are reviewed and discussed. | 2017 | 28539504 |
| epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in beijing, china. | the incidence of lower genital tract infections in china has been increasing in recent years. the link between high-risk human papillomavirus (hr-hpv) and other sexually transmitted diseases (stds) remains unclear. | 2017 | 28531212 |
| [common genital infections]. | vulvo-vaginal infections are frequently encountered by gynecologists and general practitioners. the diagnosis and the recurrence of these affections must lead to a discussion about sexually transmitted disease, notably when trichomonas vaginalis and herpetic infections are found. even if they do not correspond to classical sexually transmitted diseases, their prevalence is increased by sexual intercourses reports and the number of partners which should also be treated. it is necessary to documen ... | 2016 | 28525226 |
| a community based study on pelvic inflammatory disease in postmenopausal females: microbiological spectrum and socio-demographic correlates. | pelvic inflammatory disease (pid) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. very few studies have been done regarding post-menopausal pid. | 2017 | 28511414 |
| interaction between trichomonas vaginalis and the prostate epithelium. | most men infected with trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. this has been hypothesized to result in chronic persistent prostatic infection. adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for t. vaginalis infection. adhesion of t. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by t. vaginalis. th ... | 2017 | 28506046 |
| differential protein expressions in virus-infected and uninfected trichomonas vaginalis. | protozoan viruses may influence the function and pathogenicity of the protozoa. trichomonas vaginalis is a parasitic protozoan that could contain a double stranded rna (dsrna) virus, t. vaginalis virus (tvv). however, there are few reports on the properties of the virus. to further determine variations in protein expression of t. vaginalis, we detected 2 strains of t. vaginalis; the virus-infected (v(+)) and uninfected (v(-)) isolates to examine differentially expressed proteins upon tvv infecti ... | 2017 | 28506033 |
| aerobic vaginitis: no longer a stranger. | aerobic vaginitis (av) is the name given in 2002 to a vaginal infectious entity which was not recognized as such before. it is characterized by abnormal (dysbiotic) vaginal microflora containing aerobic, enteric bacteria, variable levels of vaginal inflammation and deficient epithelial maturation. although av and bacterial vaginosis (bv) share some characteristics, such as a diminished number or absence of lactobacilli, increased discharge (fishy smelling in bv, while in severe forms of av, a fo ... | 2017 | 28502874 |
| double-stranded rna viral infection of trichomonas vaginalis (tvv1) in iranian isolates. | the totiviridae family includes a number of viruses that can infect protozoan parasites such as leishmania and giardia and fungi like saccharomyces cerevisiae. some isolates of trichomonas vaginalis are also infected with one or more double-stranded rna (dsrna) viruses. in this study, the frequency of trichomonas vaginalis virus (tvv1) was evaluated in iranian isolates of t. vaginalis in tehran, iran. one thousand five hundred vaginal samples were collected from patients attending obstetrics and ... | 2017 | 28478201 |
| prevalence and risk factors associated with stis among women initiating contraceptive implants in kingston, jamaica. | there is limited information on rates of stis in jamaica due to syndromic management and limited aetiological surveillance. we examined the prevalence of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) and characteristics associated with stis among sexually active women who participated in a randomised trial of a progestin implant initiation in jamaica (the sino-implant study (sis)). | 2017 | 28476913 |
| evaluating the utility of syndromic case management for three sexually transmitted infections in women visiting hospitals in delhi, india. | utility of syndromic case management (scm) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. to understand the effectiveness and/or inadequacies of scm, 11000 women were recruited and examined by clinicians for infection by chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), bacterial vaginosis (bv) ... | 2017 | 28469158 |
| glycogen synthase from the parabasalian parasite trichomonas vaginalis: an unusual member of the starch/glycogen synthase family. | trichomonas vaginalis, a parasitic protist, is the causative agent of the common sexually-transmitted infection trichomoniasis. the organism has long been known to synthesize substantial glycogen as a storage polysaccharide, presumably mobilizing this compound during periods of carbohydrate limitation, such as might be encountered during transmission between hosts. however, little is known regarding the enzymes of glycogen metabolism in t. vaginalis. we had previously described the identificatio ... | 2017 | 28465215 |
| women with symptoms of a urinary tract infection but a negative urine culture: pcr-based quantification of escherichia coli suggests infection in most cases. | our objective was to examine whether or not women with symptoms of a urinary tract infection but with a negative culture (20%-30%) do have an infection. | 2017 | 28457846 |
| prevalence of human papillomavirus, chlamydia trachomatis, and trichomonas vaginalis infections in amazonian women with normal and abnormal cytology. | sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. we investigated the prevalence of human papillomavirus (hpv), chlamydia trachomatis (ct), and trichomonas vaginalis (tv), and accessed the diversity of hpv in women with normal and abnormal cytology in manaus, brazil. we used polymerase chain reaction and hpv genotyping by direct sequencing. the chi-square test wa ... | 2017 | 28453175 |
| proton pump inhibitors are associated with a reduced likelihood for sexually transmitted diseases in women in the emergency department. | proton pump inhibitors (ppis) have been shown in cell culture to kill trichomonas vaginalis (tv) at lower half maximal inhibitory concentration values than metronidazole (flagyl), the most common medication used to treat the infection. however, there have been no previous clinical investigations to determine if ppis are associated with reduced risk for tv. | 2017 | 28442805 |
| cervicovaginal levels of human β-defensin 1, 2, 3, and 4 of reproductive-aged women with chlamydia trachomatis infection. | this study included women attending primary health care units in botucatu, são paulo, brazil, to assess the cervicovaginal levels of human β-defensin (hbd) 1, 2, 3, and 4 during chlamydia trachomatis infection. | 2017 | 28430679 |
| profile of the triplex assay for detection of chlamydia, gonorrhea and trichomonas using the bd max™ system. | chlamydia, gonorrhea and trichomonas are the most common curable sti. improved access to testing could reduce infection rates and prevent sequelae. nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. areas covered: a description of the bd max™ system (max) and the bd max ct/gc/tv assay is provided along with data from a large us clinical trial. the capacity of the system for other tests and for lab developed assays is al ... | 2017 | 28425774 |
| immunocytochemistry improving the diagnosis of trichomonas vaginalis infections. | the aim of this study was to evaluate the immunocytochemistry (icc) to diagnose trichomoniasis, particularly asymptomatic infections. by culture serial dilutions, icc was able to detect 1 trophozoite/ml, while the culture was positive up to 100 trophozoites/ml. the icc in vivo detection capability was assessed in vaginal secretions of mice experimentally infected and in vaginal swabs from asymptomatic hiv-positive pregnant women compared with culture. all vaginal secretion samples from mice were ... | 2017 | 28424786 |
| expression of the enzymatically active legumain-like cysteine proteinase tvlegu-1 of trichomonas vaginalis in pichia pastoris. | the legumain-like cysteine proteinase tvlegu-1 from trichomonas vaginalis plays a major role in trichomonal cytoadherence. however, its structure-function characterization has been limited by the lack of a reliable recombinant expression platform to produce this protein in its native folded conformation. tvlegu-1 has been expressed in escherichia coli as inclusion bodies and all efforts to refold it have failed. here, we describe the expression of the synthetic codon-optimized tvlegu-1 (tvlegu-1 ... | 2017 | 28419821 |
| dorsal longitudinal foreskin cut is associated with reduced risk of hiv, syphilis and genital herpes in men: a cross-sectional study in papua new guinea. | various forms of penile foreskin cutting are practised in papua new guinea. in the context of an ecological association observed between hiv infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level. | 2017 | 28406272 |
| the anti-trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol b modulates extracellular nucleotides hydrolysis. | trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. phloroglucinols from southern brazilian hypericum species demonstrated anti-t. vaginalis and anti-leishmania amazonensis activities. the modulation of biochemical pathways involved in the control of inflammatory response by ectonucleotidases, ntpdase and ecto-5'-nucleotidase, represents new targets for combating ... | 2017 | 28390095 |
| a cross-sectional analysis of trichomonas vaginalis infection among heterosexual hiv-1 serodiscordant african couples. | trichomonas vaginalis is the most prevalent curable sti worldwide and has been associated with adverse health outcomes and increased hiv-1 transmission risk. we conducted a cross-sectional analysis among couples to assess how characteristics of both individuals in sexual partnerships are associated with the prevalence of male and female t. vaginalis infection. | 2017 | 28377421 |
| the costa of trichomonads: a complex macromolecular cytoskeleton structure made of uncommon proteins. | the costa is a prominent striated fiber that is found in protozoa of the trichomonadidae family that present an undulating membrane. it is composed primarily of proteins that have not yet been explored. in this study, we used cell fractionation to obtain a highly enriched costa fraction whose structure and composition was further analyzed by electron microscopy and mass spectrometry. | 2017 | 28369980 |
| prevalence of trichomonas vaginalis in women of reproductive age at a family health clinic. | trichomonas vaginalis is considered the most prevalent curable sexually transmitted infection, and its occurrence exceeds that of gonococcal and chlamydia infections. this parasite has been identified as responsible for the increased risk of transmission of hiv and has also been associated with prostate and cervical cancer. many carriers of t. vaginalis are asymptomatic and, when experiencing a health problem, they most often have nonspecific symptoms. the aim of this research was to estimate th ... | 2017 | 28368862 |
| transcriptomics indicates active and passive metronidazole resistance mechanisms in three seminal giardia lines. | giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. metronidazole (mtz) is a front-line anti-giardial, but treatment failure is common and clinical resistance has been demonstrated. mtz is thought to be activated within the parasite by oxidoreductase enzymes, and to kill by causing oxidative damage. in g. duodenalis, mtz resistance involves active and passive mechanisms. relatively low activity of iron-sulfur binding proteins, namely pyruvate: ... | 2017 | 28367140 |
| trichomonas vaginalis infection in symbiosis with trichomonasvirus and mycoplasma. | trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. this review focuses on symbiotic trichomonasvirus and mycoplasma carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. improved diagnostics and larger clinical inte ... | 2017 | 28366838 |
| high prevalence of curable sexually transmitted infections among pregnant women in a rural county hospital in kilifi, kenya. | women attending antenatal care (anc) in resource-limited countries are frequently screened for syphilis and hiv, but rarely for other sexually transmitted infections (stis). we assessed the prevalence of curable stis, defined as infection with either chlamydia trachomatis or neisseria gonorrhoeae or trichomonas vaginalis, from july to september 2015. | 2017 | 28362869 |
| trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide? | trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in the world. transmission: trichomoniasis is transmitted by sexual intercourse and transmission via fomites is rare. epidemiology, incidence and prevalence: the who estimates an incidence of 276 million new cases each year and prevalence of 187 million of infected individuals. however, the infection is not notifiable. pathology/symptomatology: the t. vaginalis infection r ... | 2016 | 28357378 |
| high hiv prevalence and incidence among women in southern mozambique: evidence from the mdp microbicide feasibility study. | the study aimed to assess the feasibility of conducting large scale hiv prevention clinical trials in mozambique by measuring hiv prevalence and incidence among women of reproductive age. this paper describes the baseline socio-demographic characteristics of the mozambique microbicides development programme (mdp) feasibility cohort, baseline prevalence of hiv and other stis, and hiv incidence. | 2017 | 28350843 |
| urinary infection due to balantioides coli: a rare accidental zoonotic disease in an addicted and diabetic young female in iran. | balantiosis, a rare zoonotic infection resulting in dysentery, is caused by the large ciliated protozoan parasite balantioides coli. humans acquire this organism via the faecal-oral route. very rarely, extraintestinal infections can occur in the urinary tract system. there are very few case reports of urinary balantiosis in humans. | 2016 | 28348744 |
| the prevalence of trichomoniasis and associated factors among women treated at a university hospital in southern brazil. | trichomoniasis is the most prevalent non-viral sexually transmitted disease (std) in the world; however, it remains a neglected parasitic disease. this study aimed to determine the prevalence of trichomoniasis and its associated epidemiological factors among women treated at a hospital in southern brazil. | 2017 | 28346531 |
| epigenome mapping highlights chromatin-mediated gene regulation in the protozoan parasite trichomonas vaginalis. | trichomonas vaginalis is an extracellular flagellated protozoan parasite that causes trichomoniasis, one of the most common non-viral sexually transmitted diseases. to survive and to maintain infection, t. vaginalis adapts to a hostile host environment by regulating gene expression. however, the mechanisms of transcriptional regulation are poorly understood for this parasite. histone modification has a marked effect on chromatin structure and directs the recruitment of transcriptional machinery, ... | 2017 | 28345651 |
| t. vaginalis exosome-like vesicles modify the cytokine profile and reduce inflammation in parasite-infected mice. | trichomonas vaginalis (tv) is a flagellated parasite commonly spread through sexual transmission. this protozoan initiates a severe inflammatory process, inducing nitric oxide, interleukin-6 (il-6), il-8, il-10, il-17, and il-22 production by host immune cells. the parasites elicit these responses by releasing surface lipophosphoglycan, small extracellular vesicles (exosomes) and other factors. tv exosomes are similar to mammalian exosomes and have been implicated in the modulation of il-8 secre ... | 2017 | 28345149 |
| routine testing of mycoplasma genitalium and trichomonas vaginalis. | mycoplasma genitalium (mg) and trichomonas vaginalis (tv) are common sexual transmitted infections (sti). however, most sti screening programmes do not include routinely detection of these pathogens. consequently, epidemiological data about mg and tv in the general population is lacking. the current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. | 2017 | 28301989 |
| potential of bisbenzimidazole-analogs toward metronidazole-resistant trichomonas vaginalis isolates. | a bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (ch2 to c10 h20 ) containing a meta (m) or para (p) benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole susceptible (c1) and refractory (085) trichomonas vaginalis isolates under aerobic and anaerobic conditions. compound 3m, 2,2'-[α,ω-propadiylbis(oxy-1,3-phenylene)]bis-1h-benzimidazole, displayed a 5.5-fold lower minimum inhibitory concentration (mic) towards t ... | 2017 | 28296056 |
| survey of sexually transmitted disease laboratory methods in u.s. army laboratories, 2012. | sexually transmitted diseases (std) affect primarily young people (17-24 years). the u.s. military, with many young people, strives to maintain effective std treatment and prevention programs using current methods. laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. std laboratory capabilities are assessed in civilian and military laboratories using surveys. an army laboratory survey was conducted in 2007 ... | 2017 | 28290950 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| simultaneous detection and identification of sti pathogens by multiplex real-time pcr in genital tract specimens in a selected area of apulia, a region of southern italy. | genital tract infections are globally a major cause of morbidity in sexually active individuals. the aim of this study was to investigate the prevalence and associations of co-infections of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis (mh), mycoplasma genitalium, ureaplasma urealyticum (uu) and ureaplasma parvum (up) in specimens collected from female (sf) and male (sm) patients. | 2017 | 28260146 |
| antiparasitic activity of 1,3-dioxolanes containing tellurium in trichomonas vaginalis. | the increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. in the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (ptedox 01, ptedox 02, and ptedox 03) against trichomonas vaginalis. six concentrations of these compounds were analyzed for in vitro activity against atcc 30236 isolate of t. vaginalis. ptedox 01 reported a cytotoxic effect against 100 ... | 2017 | 28236702 |
| can trichomoniasis cause pharyngitis? a case report. | we report on a heterosexual male with sore throat diagnosed as oral trichomoniasis vaginalis. | 2016 | 28228954 |
| syndromic diagnosis in evaluation of women with symptoms of vaginitis. | this review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. | 2017 | 28210940 |
| recombinant α-actinin subunit antigens of trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. | human trichomoniasis caused by trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. it has caused a series of health problems to patients. for prevention and control of infectious diseases, vaccines are usually considered as one of the most cost-efficient tools. however, until now, work on the development of t. vaginalis vaccines is still mainly focused on the screening of potential immunogens. alpha-actinin characterized by hi ... | 2017 | 28209207 |
| epitopes within recombinant α-actinin protein is serodiagnostic target for trichomonas vaginalis sexually transmitted infections. | to date there is no commercially-available serodiagnostic for women and men infected with trichomonas vaginalis. thirteen epitopes of the immunogenic t. vaginalis α-actinin (106.2-kda) are detected by sera of women patients, and 5 epitopes, a subset of the 13, are detected by sera of men. a truncated recombinant protein called act-p2 (63.5-kda) encoding the 5 epitopes is used for screening by elisa for antibody in sera of women and men. because act-p2 is poorly expressed in e. coli, we wanted al ... | 2017 | 28203642 |
| diagnosis of some genital-tract infections: part 1. an historical perspective. | making a prompt and accurate diagnosis of genital tract infections is the key to instituting appropriate treatment and the linchpin of sexually transmitted infection control. we present a brief history, not covering syphilis, of diagnostic events for each of six bacteria and one protozoan from the time of discovery up to the molecular revolution. the latter is touched upon but its impact will form the substance of a further presentation. here, hindsight is helpful in understanding the way in whi ... | 2017 | 28186463 |
| vaginal infections of albanian women infected with hpv and their impact in intraepithelial cervical lesions evidenced by pap test. | cervical cytology is the best single method for large screening of the population in identifying precancerous lesions of the uterine cervix. | 2017 | 28182076 |
| medicinal plants and their isolated compounds showing anti-trichomonas vaginalis- activity. | trichomonas vaginalis is a major of non-viral sexually-transmitted infection and an important cause of serious obstetrical and gynecological complications. treatment options for trichomoniasis are limited to nitroimidazole compounds. the increasing resistance and allergic reactions to nitroimidazole and recurrent trichomoniasis make it essential to identify and develop new drugs against trichomoniasis. medicinal plants are an important source for discovery of new medications. this review discuss ... | 2017 | 28178618 |
| a review of expedited partner therapy for the management of sexually transmitted infections in adolescents. | adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. partner notification and treatment are essential to preventing the spread of sexually transmitted infections. expedited partner therapy (ept) is a method of partner treatment used by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. the objective of this article is to review the current literature regarding ept effectiveness, patients' attitu ... | 2017 | 28167140 |
| partner notification and treatment for sexually transmitted infections among pregnant women in gaborone, botswana. | chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are sexually transmitted infections (stis) associated with adverse birth outcomes. untreated partners contribute to high rates of sti reinfection; thus, partner notification and treatment remain important components of sti care and control. a prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at princess marina hospital in gaborone, botswana who enrolled in an st ... | 2017 | 28166698 |
| impact of deploying multiple point-of-care tests with a 'sample first' approach on a sexual health clinical care pathway. a service evaluation. | to assess clinical service value of sti point-of-care test (poct) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (naat) for chlamydia trachomatis/neisseria gonorrhoeae (ct/ng) could be used as a poct in practice; feasibility of non-naat poct implementation for trichomonas vaginalis (tv) and bacterial vaginosis (bv); impact on p ... | 2017 | 28159916 |
| natural products as new treatment options for trichomoniasis: a molecular docking investigation. | trichomoniasis, caused by the parasitic protozoan trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. antibiotic resistance in t. vaginalis is increasing, but there are currently no alternatives treatment options. there is a need to discover and develop new chemotherapeutic alternatives. plant-derived natural products have long served as sources for new medicinal agents, as well as new leads for drug discove ... | 2017 | 28134827 |
| chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis screening and treatment of pregnant women in port-au-prince, haiti. | in haiti, routine screening for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) among pregnant women is not conducted; yet these sexually transmitted infections (stis) are associated with adverse birth and newborn health outcomes. we aimed to assess the acceptability and feasibility of screening and the prevalence of stis among pregnant women in port-au-prince, haiti. pregnant women of at least 18 years of age who attend haitian study group for kaposi's sar ... | 2017 | 28134005 |
| in vitro activity of nitazoxanide against some metronidazole-resistant and susceptible trichomonas vaginalis isolates. | trichomonas vaginalis cases refractory to metronidazole (mtz) treatment had been reported. this study aimed to the assessment of in vitro metronidazole resistance among trichomonas positive cases with treatment failure by determination of metronidazole minimal lethal concentration (mlc), and to the evaluation of the in vitro efficacy of nitazoxanide (ntz) as compared to metronidazole (mtz) in both resistant and susceptible isolates. drug testing was carried out by an aerobic tube assay where sus ... | 2017 | 28131737 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| prevalence of trichomoniasis among 18-48 year-old women in northwest of iran. | the aims of this study were to examine the prevalence of trichomoniasis among women aged 18 to 48 yr in ardabil, northwestern iran and the relationship between demographic factors and the risk of infection. | 2017 | 28127371 |
| molecular characterization of trichomonas vaginalis strains based on identifying their probable variations in asymptomatic patients. | the aim of this study was to identify the trichomonas vaginalis strains/haplotypes based on identifying their probable variations in asymptomatic patients referred to tabriz health centers, northwestern iran. | 2017 | 28127362 |
| [investigation of the prevalence of trichomonas vaginalis among female syrian refugees with the complaints of vaginitis aged between 15-49 years]. | since the syrian civil war began in 2011, most of the syrian refugees have immigrated to turkey due to its open gate policy and the width of the border. by the end of 2015, it was estimated that there were 2.5 million syrian refugees in turkey. many of the syrian refugees live in sanliurfa due to its location on the border with syria. trichomonas vaginalis, apart from viral agents is the most common parasite among sexually transmitted infection agents. the aim of this study was to determine the ... | 2016 | 28124964 |
| [investigation of in vitro metronidazole resistance in the clinical isolates of trichomonas vaginalis]. | trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. many studies from turkey mostly dealing with the in vitro effects of compounds and natural products against t.vaginalis have been reported, however ... | 2016 | 28124960 |