Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| the protective effect of aucubin from eucommia ulmoides against status epilepticus by inducing autophagy and inhibiting necroptosis. | eucommia ulmoides oliv. is a famous traditional chinese medicine which exhibits anti-oxidative stress ability and neuro-protective effects. aucubin is the predominant component of eucommia ulmoides oliv. our present study is intended to investigate aucubin's potential protective effects on neurons against epilepsy in the hippocampus by establishing the lithium-pilocarpine induced status epilepticus (se) rat model in vivo. aucubin (at a low dose and a high dose of 5[formula: see text]mg/kg and 10 ... | 2017 | 28387136 |
| the effects of autohydrolysis pretreatment on the structural characteristics, adsorptive and catalytic properties of the activated carbon prepared from eucommia ulmoides oliver based on a biorefinery process. | eucommia ulmoides oliver (eu) wood was consecutively treated by autohydrolysis pretreatment and chemical carbonization post-treatment based on a biorefinery process. results showed that the optimal condition of the autohydrolysis pretreatment and carbonization process yielded 10.37kg xylooligosaccharides (xos), 1.39kg degraded hemicellulosic products, 17.29kg other degraded products from hemicelluloses and 40.72kg activated carbon (sbet of 1534.06m(2)/g) from the 100kg raw materials. simultaneou ... | 2017 | 28222385 |
| aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of tgf-β stimulation. | eucommia ulmoides is an important traditional chinese medicine and has been used as a tonic with a long history. aucubin is an active component extracted from eucommia ulmoides, which has liver-protection effects. however the mechanisms are still unclear. to investigate the inhibitory effects and the underlying mechanisms of aucubin on tgf-β1-induced activation of hepatic stellate cells and ecm deposition, human hepatic stellate cells (lx-2 cells) were incubated with tgf-β1 to evaluate the anti- ... | 2017 | 28199906 |
| effects of simultaneous supplementation of laying hen with α-linolenic acid and eicosapentaenoic acid/ docosahexaenoic acid resources on egg quality and n-3 fatty acid profile. | the aim of this study was to investigate the effects of simultaneous supplementation of laying hen with a-linolenic acid (ala) resources (flax, perilla and eucommia ulmoides seeds) and eicosapentaenoic acid/docosahexaenoic acid (epa/dha) resources (schizochytrium sp.) on egg quality and n-3 polyunsaturated fatty acids (pufa) profile. | 2016 | 28111448 |
| preventive effect of eucommia leaf extract on aortic media hypertrophy in wistar-kyoto rats fed a high-fat diet. | eucommia ulmoides oliver leaf extract (ele) has been shown to have anti-hypertensive and anti-obesity effects in rats that are fed a high-fat diet (hfd). to explore the effects of chronic administration of ele on body weight, blood pressure and aortic media thickness, 7-week-old male wistar-kyoto (wky) rats were orally administered a normal diet, a 30% hfd, or a 5% ele plus hfd ad libitum for 10 weeks. the hfd treatment caused mild obesity and hypertension in the normotensive rats, while rats re ... | 2017 | 28100919 |
| evaluation of the sedative and hypnotic effects of astragalin isolated from eucommia ulmoides leaves in mice. | the purpose of this study was to evaluate the effects of astragalin on the central nervous system. astragalin is a monomeric compound found in the leaves of eucommia ulmoides using a system solvent method. in the experiments, astragalin showed significant effects on mice, including reduced spontaneous activity, increased sleep ratio, shortened sleep latency and lengthened sleep time with a subthreshold or superthreshold dose of pentobarbital sodium. in addition, astragalin effectively reduced th ... | 2016 | 28013568 |
| paenibacillus eucommiae sp. nov., isolated from a traditional chinese medicinal herbal plant eucommia ulmoides oliver. | the taxonomic status of a bacterium designated strain cpcc 100226t isolated from a traditional chinese medicinal herbal plant, e. ulmoides oliver, was characterized by using a polyphasic approach. the aerobic isolate formed pale white colonies on tryptic soy agar (tsa). cells were gram-staining-positive, rod-shaped, motile and endospore-forming. chemotaxonomic investigations revealed the presence of meso-diaminopimelic acid (meso-dap) as the diagnostic diamino acid, mk-7 as the predominant menaq ... | 2016 | 27959785 |
| megastigmane glycosides from leaves of eucommia ulmoides oliver with ace inhibitory activity. | four new megastigmane glycosides, eucomegastigsides a-d (2, 3, 5 and 7), together with three known megastigmane glycosides, (6r, 7e, 9r)-9-hydroxy-4, 7-megastigmadien-3-one-9-o-[α-l-arabinopyranosyl-(l→6)-β-d-glucopyranoside (1), foliasalacioside b1 (4) and eleganoside a (6), were isolated from the leaves of eucommia ulmoides oliver. their anti-hypertensive effect was investigated in vitro based on the inhibition of angiotensin converting enzyme (ace) using hplc. the results showed that the isol ... | 2017 | 27923676 |
| genome-wide identification of micrornas and their targets in the leaves and fruits of eucommia ulmoides using high-throughput sequencing. | micrornas (mirnas), a group of endogenous small non-coding rnas, play important roles in plant growth, development, and stress response processes. eucommia ulmoides oliver (hardy rubber tree) is one of the few woody plants capable of producing trans-1, 4-polyisoprene (tpi), also known as eu-rubber, which has been utilized as an industrial raw material and is extensively cultivated in china. however, the mechanism of tpi biosynthesis has not been identified in e. ulmoides. to characterize small r ... | 2016 | 27877179 |
| lignans extracted from eucommia ulmoides oliv. protects against ages-induced retinal endothelial cell injury. | advanced glycation end products (ages) could elicit oxidative stress, trigger and aggravate endothelium damage in several ischemic retinopathies including diabetic retinopathy (dr). the leaves of eucommia ulmoides o., also referred to as tu-chung or du-zhong, have been used for the treatment of hypertension and diabetes, showing great antioxidant activity and anti-glycation activity. lignans is one of the main bioactive components of eucommia ulmoides. this study mainly investigated the effect o ... | 2016 | 27825165 |
| extract from eucommia ulmoides oliv. ameliorates arthritis via regulation of inflammation, synoviocyte proliferation and osteoclastogenesis in vitro and in vivo. | eucommia ulmoides oliv., a valuable chinese herb, has shown a variety of health benefits. despite the widespread clinical use of this herb to treat rheumatoid arthritis (ra) in traditional chinese medicine (tcm), very few studies have described its anti-pathological effects or mechanism in ra. the present study investigated the mechanism of eucommia ulmoides oliv. in an experimental collagen-induced arthritis (cia) rat model. | 2016 | 27743778 |
| mechanism and anticancer activity of the metabolites of the endophytic fungi eucommia ulmoides oliv. | pinoresinol (pin) and pinoresinol monoglucoside (pmg) are plant-derived lignan molecules with multiple functions. we showed previously that the endophytic fungus eucommiaulmoides oliverendophytic phomopsis sp. xp-8 is able to produce pin and pmg. cultured xp-8 showed inhibition on hepg-2 and k562 cells and the major effective compounds were identified. the fungal culture significantly inhibited the activities of hepg-2 and k562 cells by decreasing their viability and inducing apoptosis via up-re ... | 2016 | 27671307 |
| effervescent granules prepared using eucommia ulmoides oliv. and moso bamboo leaves: hypoglycemic activity in hepg2 cells. | eucommia ulmoides oliv. (e. ulmoides oliv.) and moso bamboo (phyllostachys pubescens) leaves are used as folk medicines in central-western china to treat diabetes. to investigate the hypoglycemic activity of the effervescent granules prepared using e. ulmoides oliv. and moso bamboo leaves (ebeg) in hepg2 cells, ebeg were prepared with 5% of each of polysaccharides and chlorogenic acids from moso bamboo and e. ulmoides oliv. leaves, respectively. hepg2 cells cultured in a high-glucose medium were ... | 2016 | 27656239 |
| de novo sequencing of eucommia ulmoides flower bud transcriptomes for identification of genes related to floral development. | eucommia ulmoides oliver is a woody perennial dioecious species native to china and has great economic value. however, little is known about flower bud development in this species. in this study, the transcriptomes of female and male flower buds were sequenced using the illumina platform, a next-generation sequencing technology that provides cost-effective, highly efficient transcriptome profiling. in total, 11,558,188,080 clean reads were assembled into 75,065 unigenes with an average length of ... | 2016 | 27486566 |
| simultaneous determination of catalpol, aucubin, and geniposidic acid in different developmental stages of rehmannia glutinosa leaves by high performance liquid chromatography. | although r. glutinosa roots are currently the only organ source in clinics, its leaves are a potential supplement for the roots especially in extraction of some important bioactive compounds. our early work found that the contents of catalpol and total iridoid glycosides varied among different developmental stages of r. glutinosa leaves. aucubin and geniposidic acid, the abundant major bioactive compounds in eucommia ulmoides and gardenia jasminoides, respectively, were found present in r. gluti ... | 2016 | 27429834 |
| chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. | an efficacious antidepressant without unwanted side effects is need urgently at present. this study aimed to investigate whether treatment with four chinese herbal medicines (chms), namely radix astragali, saposhnikovia divaricate (sd), eucommia ulmoides oliv. bark (eu), and corydalis yanhusuo w. t. wang (c. yanhusuo), could reverse the effects of chronic mild stress (cms) in a depression-like mouse model and the potential mechanism(s) of their action. | 2016 | 27416803 |
| improvement in raw meat texture of cultured eel by feeding of tochu leaf powder. | the muscle of eels fed tochu (eucommia ulmoides oliver) leaf powder was 1.8 times harder than the control. the component analysis showed no difference in moisture, lipid, or protein content between the muscles of the control and the tochu-fed eels. not only the extracted neutral fat but also the compound fat of the raw muscles of the tochu-fed eel and the control had the same tlc patterns and fatty acid composition by gas chromatographic analysis. there was a great difference between the tochu-f ... | 1993 | 27314770 |
| [anti-hypertensive effect of total flavonoids of cydonia oblonga leaves and its mechanism based on anti-inflammatory function]. | to study the anti-hypertensive effect of total flavonoids of cydonia oblonga leaves in spontaneously hypertensive rats, then to preliminarily investigate the mechanism of action based on anti-inflammatory function. | 2015 | 27254930 |
| isolation and characterization of microsatellite markers for eucommia ulmoides (eucommiaceae), an endangered tree, using next-generation sequencing. | eucommia ulmoides oliver, a single extant species of eucommiaceae, is an endemic dioecious tree in china. the natural resources of e. ulmoides have rapidly declined in recent years because of the over-collection of its cortex. to design a suitable protection strategy, it is necessary to develop a set of molecular markers to investigate genetic diversity and population structure of e. ulmoides. pyrosequencing of an enriched microsatellite library by roche 454 flx+ platform was used to isolate sim ... | 2016 | 27173246 |
| eucommia ulmoides extracts prevent the formation of advanced glycation end products. | proteins non-enzymatically react with reducing sugars to form advanced glycation end-products (ages), resulting in the induction of protein denaturation. because the levels of age increase with age and are elevated in age-related diseases, such as diabetes and atherosclerosis, the intake of compound(s) that inhibit the formation of ages by daily meal may represent a potential strategy for preventing age-related diseases. in this study, we measured the inhibitory effects of several eucommia ulmoi ... | 2016 | 27080730 |
| characterization of glycolytic pathway genes using rna-seq in developing kernels of eucommia ulmoides. | eucommia ulmoides oliver, the only member of the eucommiaceae family, is a rare and valuable tree used to produce a highly valued traditional chinese medicine and contains α-linolenic acid (ala) up to 60% of the total fatty acids in the kernels (embryos). glycolysis provides both cellular energy and the intermediates for other biosynthetic processes. however, nothing was known about the molecular basis of the glycolytic pathway in e. ulmoides kernels. the purposes of this study were to identify ... | 2016 | 27074598 |
| the anti-inflammatory activity of eucommia ulmoides oliv. bark. involves nf-κb suppression and nrf2-dependent ho-1 induction in bv-2 microglial cells. | in the present study, we investigated the anti-inflammatory properties of eucommia ulmoides oliv. bark. (eue) in lipopolysaccharide (lps)-stimulated microglial bv-2 cells and found that eue inhibited lps-mediated up-regulation of pro-inflammatory response factors. in addition, eue inhibited the elevated production of pro-inflammatory cytokines, mediators, and reactive oxygen species (ros) in lps-stimulated bv-2 microglial cells. subsequent mechanistic studies revealed that eue suppressed lps-ind ... | 2016 | 27068259 |
| health-promoting properties of eucommia ulmoides: a review. | eucommia ulmoides (eu) (also known as "du zhong" in chinese language) is a plant containing various kinds of chemical constituents such as lignans, iridoids, phenolics, steroids, flavonoids, and other compounds. these constituents of eu possess various medicinal properties and have been used in chinese traditional medicine (tcm) as a folk drink and functional food for several thousand years. eu has several pharmacological properties such as antioxidant, anti-inflammatory, antiallergic, antimicro ... | 2016 | 27042191 |
| eucommia bark (du-zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats. | eucommia bark, eucommia ulmoides oliver barks (du-zhong in mandarin), is an herb used for renal dysfunction in chinese traditional medicine. in an attempt to develop this herb as a treatment for diabetic nephropathy (dn), we investigated the effects of du-zhong on renal dysfunction in type 1-like diabetic rats. | 2016 | 27041999 |
| antidepressant potential of chlorogenic acid-enriched extract from eucommia ulmoides oliver bark with neuron protection and promotion of serotonin release through enhancing synapsin i expression. | eucommia ulmoides oliver (e. ulmoides) is a traditional chinese medicine with many beneficial effects, used as a tonic medicine in china and other countries. chlorogenic acid (cga) is an important compound in e. ulmoides with neuroprotective, cognition improvement and other pharmacological effects. however, it is unknown whether chlorogenic acid-enriched eucommia ulmoides oliver bark has antidepressant potential through neuron protection, serotonin release promotion and penetration of blood-cere ... | 2016 | 26927040 |
| neuroprotective effect of lignans extracted from eucommia ulmoides oliv. on glaucoma-related neurodegeneration. | glaucoma is a progressive neurodegenerative disease, characterized by retinal ganglion cells (rgcs) and axon degeneration. the development of neuroprotective drug is required for improving the efficiency of glaucoma treatment. eucommia ulmoides oliv. has been used as a source of traditional medicine and as a beneficial health food. lignans is one of the main bioactive components of eucommia ulmoides. here, we show that lignans protects rgcs against oxidative stress-induced injury in vitro. moreo ... | 2016 | 26829935 |
| quantitative trait locus analysis of leaf morphological characters, yield-related traits, and secondary metabolite contents in eucommia ulmoides. | eucommia ulmoides is cultivated for the production of eucommia rubber and chinese herbal drugs. molecular breeding methods, such as marker-assisted selection (mas), have the potential to improve the efficiency of e. ulmoides breeding. quantitative trait locus (qtl) analysis was applied to identify marker-trait associations for e. ulmoides using an f1 mapping population of 152 individuals derived from a cross between the wild genotype xiaoye and the cultivar qinzhong no. 1. a total of 78 qtls wer ... | 2015 | 26782433 |
| [chemical constituents of eucommia ulmoides in guizhou province]. | to study the chemical constituents of eucommia ulmoides in guizhou province. | 2015 | 26767291 |
| application of ionic liquids based enzyme-assisted extraction of chlorogenic acid from eucommia ulmoides leaves. | a new approach for ionic liquid based enzyme-assisted extraction (ileae) of chlorogenic acid (cga) from eucommia ulmoides is presented in which enzyme pretreatment was used in ionic liquids aqueous media to enhance extraction yield. for this purpose, the solubility of cga and the activity of cellulase were investigated in eight 1-alkyl-3-methylimidazolium ionic liquids. cellulase in 0.5 m [c6mim]br aqueous solution was found to provide better performance in extraction. the factors of ileae proce ... | 2016 | 26709302 |
| the restorative effects of eucommia ulmoides oliver leaf extract on vascular function in spontaneously hypertensive rats. | eucommia ulmoides oliv. leaf is a traditional chinese antihypertensive and antidiabetic medicine. we examined the effects of chronic eucommia leaf extract (ele) administration on artery function and morphology in spontaneously hypertensive rats (shrs). ele was orally administered via normal diet ad libitum to six-week-old male shrs at a concentration of 5% for seven weeks. acetylcholine (ach)-induced endothelium-dependent relaxation, sodium nitroprusside (snp)-induced endothelium-independent rel ... | 2015 | 26690110 |
| eucommicin a, a β-truxinate lignan from eucommia ulmoides, is a selective inhibitor of cancer stem cells. | cancer stem cells (cscs) constitute a small population of undifferentiated cells within a tumor that have the ability to self-renew and drive tumor formation, thus behaving as cancer-initiating cancer cells. therapeutic interventions that eliminate cscs are necessary to completely cure patients, since cscs are a crucial source of tumor recurrence and metastasis. an induced csc-like (icscl) model was recently established using induced pluripotent stem cells (ipscs). in this study, a natural produ ... | 2016 | 26678322 |
| biosynthesised palladium nanoparticles using eucommia ulmoides bark aqueous extract and their catalytic activity. | palladium nanoparticles (pdnps) are of great importance as catalytic materials. their synthesis has been widely studied and interest in their properties is growing. bio-based methods might be a greener option for designing the pdnps with reduced environmental impacts. this study reports the synthesis of pdnps by utilising the aqueous extract of medicinally important eucommia ulmoides (e. ulmoides) bark which functions as both reducing and capping agent in moderate reaction conditions. reduction ... | 2015 | 26647810 |
| vasodilatory effect of wogonin on the rat aorta and its mechanism study. | wogonin, a natural flavonoid, is one of the bioactive compounds of the medicinal herb eucommia ulmoides oliv. widely used in southeastern asia for treating hypertension. however, the molecular mechanisms for the therapeutic benefits remain largely unclear. the present study investigated the vasodilatory effect of wogonin and its possible mechanisms. the flavonoid (0.1-100 µm) caused concentration-dependent relaxations in endothelium-intact aortic rings precontracted with norepinephrine (ne, 1 µm ... | 2015 | 26632179 |
| characterization and immunoenhancement activities of eucommia ulmoides polysaccharides. | the aim of this study is to investigate the physicochemical properties, monosaccharide composition and immunomodulatory effects of eucommia ulmoides oliv. polysaccharide. the average molecular weight (mw) of eups was 11.4632 × 10(5)da. the monosaccharide components of eups were glucose, fructose, mannose, fucose, galactose and arabinose with a relative mass of 36.6%, 16.6%, 14.2%, 15.7%, 9.5% and 7.4%, respectively. in in vitro experiments, eups (1.2-75 μg/ml) treatment of dendritic cells (dc) i ... | 2016 | 26572415 |
| enzymatic hydrolysis and simultaneous extraction for preparation of genipin from bark of eucommia ulmoides after ultrasound, microwave pretreatment. | a continuous process based on the combination of ultrasounds and/or microwaves pretreatments followed by enzymatic hydrolysis and simultaneous extraction (ehse) has been proposed to recover genipin from eucommia ulmoides bark. at first, in the pretreatment step, the mixture of 1.0 g dried bark powder and 10 ml deionized water were irradiated by microwave under 500 w for 10 min. then, in hydrolysis step, the optimal conditions were as follows: 0.5 mg/ml of cellulase concentration, 4.0 ph of enzym ... | 2015 | 26501242 |
| simultaneous qualitation and quantitation of natural trans-1,4-polyisoprene from eucommia ulmoides oliver by gel permeation chromatography (gpc). | natural trans-1,4-polyisoprene (tpi) as a functional biomaterial has aroused great interest for rubber industrial product use. here, we proposed a method that enables simultaneous analysis of the content and molecular-weight distribution (mwd) of natural tpi by gel permeation chromatography (gpc). the natural tpis were collected from leaves, fruit coatings and bark of eucommia ulmoides oliver (e. ulmoides) through toluene extraction followed by ethanol purification. the results of tpi contents f ... | 2015 | 26435186 |
| [study on quality standard of eucommia ulmoides based on absorbed active components in rat plasma]. | the method was established for determination of geniposidic acid, chlorogenic acid, pinoresinoldiglucoside, which are three kinds of constituents of eucommia ulmoides absorbed into the blood components. lc-ms/ms technique was applied to determine the blood components of the bloodstream after administration of e. ulmoides extract. at the same time, hplc was used for detection of the ingredients content of the blood sample from 23 batches of e. ulmoides. the results showed that geniposidic acid, c ... | 2015 | 26323146 |
| microwave-assisted extraction and purification of chlorogenic acid from by-products of eucommia ulmoides oliver and its potential anti-tumor activity. | an efficient method for the rapid extraction, separation and purification of chlorogenic acid (cga) from by-products of eucommia ulmoides oliver (e. ulmoides) by microwave-assisted extraction (mae) coupled with high-speed counter-current chromatography (hsccc) was developed. the optimal mae parameters were evaluated by response surface methodology (rsm), and they were extraction time of 12 min, microwave power of 420 w, ethanol concentration of 75 %, solvent/sample ratio of 30:1 (ml/g), yield of ... | 2015 | 26243912 |
| genetic diversity in intraspecific hybrid populations of eucommia ulmoides oliver evaluated from issr and srap molecular marker analysis. | eucommia ulmoides oliver, the only extant species of eucommiaceae, is a second-category state-protected endangered plant in china. evaluation of genetic diversity among some intraspecific hybrid populations of e. ulmoides oliver is vital for breeding programs and further conservation of this rare species. we studied the genetic diversity of 130 accessions from 13 e. ulmoides intraspecific hybrid populations using inter-simple sequence related (issr) and sequence-related amplified polymorphism (s ... | 2015 | 26214420 |
| eucommia ulmoides oliv. (du-zhong) lignans inhibit angiotensin ii-stimulated proliferation by affecting p21, p27, and bax expression in rat mesangial cells. | cortex eucommiae (du-zhong) is the dried bark of the eucommia ulmoides oliv. the natural products identified from du-zhong include lignans, iridoids, flavonoids, polysaccharides, terpenes, and proteins, liu et al. (2012). lignans, the main bioactive components, were protective against hypertensive renal injury in spontaneous hypertensive rats in our previous study, li et al. (2012). moreover, eucommia lignans also diminished aldose reductase (ar) overexpression in the kidney, li et al. (2012). h ... | 2015 | 26170892 |
| herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice. | we examined the effect of the daily ingestion of herb extract from eucommia ulmoides leaves and korean ginseng on skin damage induced by repeated uv irradiation of hairless mice. the herb extract was orally administered to mice at a dose of 1000 mg/kg/day. the hydration of mice dorsal skin decreased significantly with repeated uv irradiation, but did not decrease when the herb extract was administered for seven weeks. transepidermal water loss (tewl) increased with uv irradiation, but decreased ... | 2015 | 26011399 |
| iridoid constituents from the male flower of eucommia ulmoides and their promotion proliferation on esf-1. | four new iridoids (1, 2, 12, and 13), together with nine known iridoids (3-11), were isolated from the male flowers of eucommia ulmoides oliver and were characterized as 3β-methoxyartselawnin c (1), 6β-hydroxyl-1β,3β-dimethoxyartsclaenin iii (2), 3,4-dihydro-3β-ethoxyasperuloside (12) and 3,4-dihydro-3β-ethoxydesacetylasperuloside (13) by extensive analyses of their 1d and 2d nmr spectroscopy and mass spectra. all of the isolated compounds were assayed for the promoting proliferation of skin fib ... | 2015 | 25996193 |
| neuroprotective effects of eucommia ulmoides oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system. | parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. the purpose of this study was to investigate potential in vivo protective effects of duzhong against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), as well as the bioactive constituents against 1-methyl-4-phenylpyridinium (mpp(+)) toxicity in vitro. | 2015 | 25994206 |
| a uplc-ms method for simultaneous determination of geniposidic acid, two lignans and phenolics in rat plasma and its application to pharmacokinetic studies of eucommia ulmoides extract in rats. | the bark of eucommia ulmoides is a well-known chinese herbal medicine that is used to regulate blood pressure and reduce blood sugar and fats, as well as an antioxidant and antimicrobial agent. here we describe the development of a sensitive ultrahigh performance liquid chromatography-tandem mass spectrum method for the simultaneous determination of five major active ingredients of e. ulmoides bark extract, namely, geniposidic acid (ga), protocatechuic acid (pca), chlorogenic acid (ca), (+)-pino ... | 2016 | 25990756 |
| uplc-ms/ms determination and gender-related pharmacokinetic study of five active ingredients in rat plasma after oral administration of eucommia cortex extract. | eucommiae cortex (ec), the bark of eucommia ulmoides oliv., has been traditionally used to treat many diseases in china for more than 2000 years. the pharmacological effects are primarily attributed to the presence of lignans, iridoids and phenolics, which are main active ingredients in ec. | 2015 | 25910535 |
| [study on chemical constituents of eucommia ulmoides leaves]. | to investigate the chemical constituents of eucommia ulmoides leaves. | 2014 | 25895383 |
| suppression of splenic lymphocyte proliferation by eucommia ulmoides and genipin. | we investigated the modulation of innate and adaptive immune cell activation by eucommia ulmoides oliver extract (eue) and its ingredient genipin. as an innate immunity indicator, the phagocytic activity of macrophages was determined by measuring engulfed, fluorescently labeled escherichia coli. as a surrogate marker for the respective activation of cellular and humoral adaptive immunity, concanavalin a (con a) and lipopolysaccharide (lps) induction of primary splenocyte proliferation was assaye ... | 2015 | 25879499 |
| genetic diversity and population structure of eucommia ulmoides oliver, an endangered medicinal plant in china. | eucommia ulmoides oliver, one of the tertiary relict species found only in china, is the only extant species of eucommiaceae. using inter-simple sequence repeat (issr) and sequence-related amplified polymorphism (srap) markers, we studied the genetic diversity and population genetic structure of 187 accessions from 17 e. ulmoides populations throughout its main distribution in china. a total of 65 bands were amplified using eight issr primers, of which 50 bands (76.9%) were polymorphic. meanwhil ... | 2015 | 25867393 |
| chlorogenic acid-enriched extract from eucommia ulmoides leaves inhibits hepatic lipid accumulation through regulation of cholesterol metabolism in hepg2 cells. | eucommia ulmoides oliver (eucommiaceae) leaf exhibits beneficial lipid-lowering and anti-obesity effects. however, the mechanisms remain unknown. | 2016 | 25845641 |
| [triterpenes constituents from male flowers of eucommia ulmoides]. | nine triterpenes compounds were isolated from the male flowers of eucommia ulmoides by recrystallization and chromatographic techniques over silica gel, sephadex lh-20, and rp-18 gel. their chemical structures were identified on the basis of spectral analysis and as 3-oxo-12-en-ursane-28-o-α-l-arabinofuranosyl (1 --> 6) -β-d-glucopyranoside (1), 2α, 3β-dihydroxyurs-12-en-28-oic acid(28 --> 1) -β-d-glucopyranosyl ester (2), ursolic acid (3), α-amyrin (4), uvaol (5), ursolic acid acetate (6), 3-o- ... | 2014 | 25775798 |
| effect of structural changes of lignin during the autohydrolysis and organosolv pretreatment on eucommia ulmoides oliver for an effective enzymatic hydrolysis. | eucommia ulmoides oliver (eu) wood was successively treated by autohydrolysis and organosolv pretreatment integrated process. autohydrolysis pretreatment facilitated xylooligosaccharides production, subsequent organosolv pretreatment to obtain high-purity lignin and digestible cellulose-rich residue. results showed that the lignin fractions obtained exhibited smaller molecular weights, narrow polydispersity, more phenolic oh groups and higher syringyl/guaiacyl ratios (s/g) than the milled wood l ... | 2015 | 25754353 |
| [analysis of genetic diversity of cultivated eucommia ulmoides from guizhou province by phenotypic traits and scot markers]. | to explore the phenotypic characteristics and the genetic diversity of cultivated eucommia ulmoides from guizhou province. | 2014 | 25726639 |
| controllable biosynthesis of gold nanoparticles from a eucommia ulmoides bark aqueous extract. | the present work reports the green synthesis of gold nanoparticles (aunps) by water extract of eucommia ulmoides (e. ulmoides) bark. the effects of various parameters such as the concentration of reactants, ph of the reaction mixture, temperature and the time of incubation were explored to the controlled formation of gold nanoparticles. the characterization through high resolution-transmission electron microscopic (hrtem), energy dispersive x-ray spectroscopy (edx) and x-ray diffraction (xrd) in ... | 2015 | 25699695 |
| soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of eucommia ulmoides oliver (duzhong). | eucommia ulmoides leaves have been used as a functional food and drink in china. the purpose of this study was to identify the bioactive constituents with soluble epoxide hydrolase (seh) inhibitory activity and anti-inflammatory properties. twenty-seven known compounds (1-27) were isolated from the leaves of e. ulmoides oliver, and their structures were identified by nmr and esims analysis; three of these, 2,5-dimethoxy-3-glucopyranosyl cinnamic alcohol (11), foliasalacioside e2 (26), and icaris ... | 2015 | 25679330 |
| the ethanol extract of eucommia ulmoides oliv. leaves inhibits disaccharidase and glucose transport in caco-2 cells. | the cortex and leaves of eucommia ulmoides oliv. from the family eucommiaceae are traditional chinese medicines (tcm). roasted eucommiae cortex is utilized to reinforce the muscles and lungs, lower blood pressure and improve the tone of the liver and kidneys, while eucommia ulmoides leaves (eul) are traditionally used as folk remedies to treat diabetes. | 2015 | 25620383 |
| eucommia ulmoides oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis. | eucommia ulmoides oliv. bark (eu) is a common traditional chinese herbal medicine for treatment of osteoarthritis (oa), but its therapeutic effect on oa and the underlying mechanisms have not been fully clarified. our previous study showed that eucommia ulmoides oliv. bark aqueous extract (eue) had a protective effect on cartilage, and this study was aimed to investigate the anti-osteoarthritis effect and mechanisms of eue in a rat model of osteoarthritis. | 2015 | 25575468 |
| neuroprotective effects of macranthoin g from eucommia ulmoides against hydrogen peroxide-induced apoptosis in pc12 cells via inhibiting nf-κb activation. | oxidative stress-mediated cellular injury has been considered as a major cause of neurodegenerative diseases including alzheimer and parkinson diseases. the scavenging of reactive oxygen species (ros) mediated by antioxidants may be a potential strategy for retarding the disease's progression. macranthoin g (mcg), isolated from eucommia ulmoides, is a derivative from chlorogenic acid methyl ester and caffeic acid. this study is aimed to investigate the protective role of mcg against the cytotoxi ... | 2014 | 25451577 |
| studies on resin purification process optimization of eucommia ulmoides oliver and its antihypertensive effect mechanism. | through research it is found that the barks, stems, fruits and flowers of eucommia ulmoides contain various compositions, such as lignin, cycloalkane and phenylpropanoids. the modern pharmacological research shows that eucommia ulmoides has many functions, such as anti-aging, antitumor and bone cell proliferation. this paper studied the resin purification process optimization conditions and antihypertensive effect of eucommia ulmoides oliver. | 2014 | 25435636 |
| simultaneous quantification of eleven bioactive components of male flowers of eucommia ulmoides oliver by hplc and their quality evaluation by chemical fingerprint analysis with hierarchical clustering analysis. | eucommia ulmoides oliv (eu), a dioecious perennial angiosperm, is one of the oldest tonics in chinese traditional medicine. the tea of male flowers of eu has been become popularities and seen as aspirational health care tea in china. there were no enough marks and effective method to control the quality of male flowers of eu. | 2014 | 25422543 |
| report: molecular basis of antibacterial activities in extracts of eucommia ulmoides wood. | as one of the famous medicinal plants in china, the bark of eucommia ulmoides is considered as the important traditional chinese medicine. however, the constituents of eucommia ulmoides wood isn't used effectively. therefore, the molecules of wood extracts in eucommia ulmoides are studied to further utilize the resources. the results show that the optimal extraction time period of ethanol/methanol extraction, petroleum ether/acetic ether extraction, and benzene/alcohol extraction are 3h, 5h, and ... | 2014 | 25410085 |
| screening and identification of a cutinase-producing rhodotorula mucilaginosa and properties of the cutinase. | eucommia leaf contains large amounts of natural active products. in extracting the substances, the most important is the removal of the cuticle layer on the leaves and the cell wall in the leaves of eucommia ulmoides. but the removal of the cuticle layer is a technical difficulty now. cutinase (ec3.1.1.74) is a multifunctional enzyme with a common alpha/beta fold structure belonging to hydroplane that can make a substantial degradation of horny fatty acids. so this study isolated bacteria capabl ... | 2015 | 25377248 |
| genetic diversity and relationships among chinese eucommia ulmoides cultivars revealed by sequence-related amplified polymorphism, amplified fragment length polymorphism, and inter-simple sequence repeat markers. | sequence-related amplified polymorphism (srap), amplified fragment length polymorphism (aflp), and inter-simple sequence repeat (issr) markers were used to estimate the genetic diversity and relationships among eucommia ulmoides cultivars in china. a total of 240, 192, and 150 dna fragments were detected by 10 srap primer combinations, 10 aflp primer combinations, and 10 issr primers, among which 89.2, 65.1, and 88.0% of the fragments were polymorphic, respectively. cluster analysis revealed tha ... | 2014 | 25366761 |
| [chemical constituents of eucommia ulmoides]. | to study the chemical compositions of eucommia ulmoides. | 2014 | 25335288 |
| [study on ecological suitability regionalization of eucommia ulmoides in guizhou]. | to study the ecological suitability regionalization of eucommia ulmoides, for selecting artificial planting base and high-quality industrial raw material purchase area of the herb in guizhou. | 2014 | 25335280 |
| asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of eucommia leaves with anti-obesity activity. | eucommia leaves (eucommia ulmoides oliver) contain chlorogenic acid (a caffeic acid derivative) and geniposidic acid and asperuloside (asp), iridoid glucosides used in beverages. we used a metabolic syndrome rat model, produced by feeding a 35 % high-fat diet (hfd), to examine potential anti-obesity and anti-metabolic syndrome effects and mechanisms of chronic administration of asp. these effects were compared with eucommia leaf extract (ele), the positive control, which exhibits anti-obesity ef ... | 2012 | 25191539 |
| [phenylpropanoids constituents of eucommia ulmoides leaves]. | to investigate phenylpropanoids constituents from eucommia ulmoides leaves. | 2014 | 25174105 |
| effect of quercetin-3-o-sambubioside isolated from eucommia ulmoides male flowers on spontaneous activity and convulsion rate in mice. | the purpose of this study was to evaluate the effects of quercetin-3-o-sambubioside on the neural system. quercetin-3-o-sambubioside is a monomeric compound found in eucommia ulmoides male flowers from which it was extracted using a system solvent method. in the experiments, spontaneous activity and convulsion rate in mice were recorded, and quercetin-3-o-sambubioside shows eminent effects similar to nikethamide on increasing spontaneous activity and stimulating the nerve center to enhance excit ... | 2014 | 25098932 |
| effects of eucommia ulmoides extract on longitudinal bone growth rate in adolescent female rats. | eucommia ulmoides is one of the popular tonic herbs for the treatment of low back pain and bone fracture and is used in korean medicine to reinforce muscles and bones. this study was performed to investigate the effects of e. ulmoides extract on longitudinal bone growth rate, growth plate height, and the expressions of bone morphogenetic protein 2 (bmp-2) and insulin-like growth factor 1 (igf-1) in adolescent female rats. in two groups, we administered a twice-daily dosage of e. ulmoides extract ... | 2015 | 25087723 |
| anti-inflammatory activity of iridoid and catechol derivatives from eucommia ulmoides oliver. | neuroinflammation and pro-inflammatory mediators play key roles in the pathogenesis of neurodegenerative diseases including stroke, which account for a significant burden of morbidity and mortality worldwide. recently, the unsatisfactory pharmacotherapy and side effects of the drugs led to the development of alternative medicine for treating these diseases. du zhong (dz), eucommia ulmoides oliver leaves, is a commonly used herb in the therapy of stroke in china. we hypothesize that the component ... | 2014 | 25065689 |
| relationship between progeny growth performance and molecular marker-based genetic distances in eucommia ulmoides parental genotypes. | progeny performances, variations and combining abilities for growth traits were evaluated in a factorial mating design of eucommia ulmoides. three marker systems, sequence-related amplified polymorphism, amplified fragment length polymorphism, and inter-simple sequence repeat, were used to determine genetic distances between parents. correlations of genetic distances with progeny performances, within-family coefficients of variation and specific-combining abilities were established for height an ... | 2014 | 25062409 |
| [chemical constituents of leaf of eucommia ulmoides]. | ten compounds were isolated from the leaf of eucommia ulmoides by means of recrystallization and chromatographic techniques such as d-101 macroporous resin, mci resin, ods gel, sephadex lh-20 and rp-hplc. their structures were identified by nmr spectral analyses as kaempferide 3-o-beta-d-glucoside (1), quercetin-3-o-beta-d-glucoside (2), quercetin (3), quercetin-3-o-beta-d-xylosyl-(1-->2)-beta-d-galactoside (4), kaempferol-3-o-alpha-l-rhamnosyl-(1-->6)-beta-d-glucoside (5), (2s,3s)-taxifolin 3-o ... | 2014 | 25039180 |
| lc/ms/ms determination and pharmacokinetic studies of six compounds in rat plasma following oral administration of the single and combined extracts of eucommia ulmoides and dipsacus asperoides. | to establish and apply a new lc/ms/ms method for the simultaneous, quantitative determination of six ingredients, aucubin (au), geniposide (gp), geniposidic acid (gpa), pinoresinol diglucoside (pdg), secologanin (slg), and loganin (lg) in single and combined extracts of eucommia ulmoides and dipsacus asperoides. | 2014 | 24969529 |
| 5-(hydroxymethyl)-2-furaldehyde inhibits adipogenic and enhances osteogenic differentiation of rat bone mesenchymal stem cells. | eucommiae cortex (eucommia ulmoides oliver bark) has been used for anti-osteoporosis usually as an ethnic drug for hundred years in china. in this study, a bioactive compound, 5-(hydroxymethyl)-2-furaldehyde (5-hmf), was isolated from eucommiae cortex. we found that after rat bone mesenchymal stem cells (bmscs) were induced by 5-hmf at the concentration of 0.05, 0.10 and 0.20 microg/ml in the normal medium for 7 and 14 days, the mrna expression of alp, col1alpha1 (7 days only), ocn and opn incre ... | 2014 | 24868876 |
| the first genetic linkage map of eucommia ulmoides. | in accordance with pseudo-testcross strategy, the first genetic linkage map of eucommia ulmoides oliv. was constructed by an f1 population of 122 plants using amplified fragment length polymorphism (aflp) markers. a total of 22 aflp primer combinations generated 363 polymorphic markers. we selected 289 markers segregating as 1:1 and used them for constructing the parent-specific linkage maps. among the candidate markers, 127 markers were placed on the maternal map lf and 108 markers on the pater ... | 2014 | 24840819 |
| effects of total lignans from eucommia ulmoides barks prevent bone loss in vivo and in vitro. | the present study systematically investigate the in vivo and in vitro effect of total lignans (tl) extracted from eucommia ulmoides oliv. barks on bone formation using ovariectomy rat model and primary cultures of rat osteoblasts. | 2014 | 24786573 |
| [comparative study on distribution of endophytic fungi in eucommia barks from different habitats]. | a total of 152 strains of endophytic fungi were isolated from the barks of eucommia ulmoides in three regions (lueyang country, zunyi country, cili country). based on morphological characteristics and analysis of its sequences, these strains were identified into 8 genera. thereinto phomopsis, diaporthe and alternaria were common genera to eucommia barks from different sites. but the dominant genus was different: alternaria was the dominant genus in the barks from cili country, and phomopsis was ... | 2014 | 24761632 |
| comparison of the effects of high energy carbon heavy ion irradiation and eucommia ulmoides oliv. on biosynthesis butyric acid efficiency in clostridium tyrobutyricum. | clostridium tyrobutyricum is well documented as a fermentation strain for the production of butyric acid. in this work, using high-energy carbon heavy ion irradiated c. tyrobutyricum, then butyric acid fermentation using glucose or alkali and acid pretreatments of eucommia ulmoides oliv. as a carbon source was carried out. initially, the modes at ph 5.7-6.5 and 37°c were compared using a model medium containing glucose as a carbon source. when the 72gl(-1) glucose concentration was found to be t ... | 2014 | 24704888 |
| eucommia ulmoides cortex, geniposide and aucubin regulate lipotoxicity through the inhibition of lysosomal bax. | in this study we examined the inhibition of hepatic dyslipidemia by eucommia ulmoides extract (eue). using a screening assay for bax inhibition we determined that eue regulates bax-induced cell death. among various cell death stimuli tested eue regulated palmitate-induced cell death, which involves lysosomal bax translocation. eue rescued palmitate-induced inhibition of lysosomal v-atpase, α-galactosidase, α-mannosidase, and acid phosphatase, and this effect was reversed by bafilomycin, a lysoso ... | 2014 | 24586300 |
| lignans from the bark of eucommia ulmoides inhibited ang ii-stimulated extracellular matrix biosynthesis in mesangial cells. | tree bark of eucommia ulmoides oliv., (commonly well-known as "du-zhong" in china), has been used to treat hypertension, hypercholesterolemia, hyperglycemia, hepatic fibrosis and renal injury. this study aims to investigate the effects of lignans extracted from the bark of eucommia ulmoides oliv. on ang ii-induced proliferation and extracellular matrix biosynthesis in rat mesangial cells. | 2014 | 24524265 |
| a molecular genetic linkage map of eucommia ulmoides and quantitative trait loci (qtl) analysis for growth traits. | eucommia ulmoides is an economically important tree species for both herbal medicine and organic chemical industry. effort to breed varieties with improved yield and quality is limited by the lack of knowledge on the genetic basis of the traits. a genetic linkage map of e. ulmoides was constructed from a full-sib family using sequence-related amplified polymorphism, amplified fragment length polymorphism, inter-simple sequence repeat and simple sequence repeat markers. in total, 706 markers were ... | 2014 | 24477264 |
| improved on-line high performance liquid chromatography method for detection of antioxidants in eucommia ulmoides oliver flower. | eucommia ulmoides oliver is a traditional chinese medicine and material for functional food with a strong antioxidant activity. to investigate antioxidants in e. ulmoides oliver flower, an improved on-line high performance liquid chromatography method with the radical cation 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (abts(+)) as a stable model free radical for the detection of radical scavenging ability was developed. the radical concentration, flow rate, and length of reaction coil wer ... | 2014 | 24468073 |
| du-zhong (eucommia ulmoides) prevents disuse-induced osteoporosis in hind limb suspension rats. | du-zhong has a long history of being used in traditional chinese formulas to treat bone related diseases. the objective of the present study is to systematically investigate the effects of du-zhong cortex extract (dzce) on disuse-induced osteoporosis. rats were randomly divided into four groups, and three groups were treated with hind limb suspension (hls). control and hls group received deionized distilled water, while the other two groups received alendronate (2.0 mg/kg/day) and dzce (300 mg/k ... | 2014 | 24467541 |
| eucommia ulmoides oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in sh-sy5y cells. | eucommia ulmoides oliv. bark. (eue) has commonly been used to fortify the muscles and lungs, lower blood pressure, prevent miscarriage, improve liver and kidney tone, and promote longevity as a traditional tonic medicine in korea, china, and japan. | 2014 | 24440915 |
| inhibitory effects of eucommia ulmoides oliv. bark on scopolamine-induced learning and memory deficits in mice. | eucommia ulmoides oliv. bark (eue) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. in this study, we tested the effects of eue aqueous extract in graded doses to protect and enhance cognition in scopolamine-induced learning and memory impairments in mice. eue significantly improved the impairment of short-term or working memory induced by scopolamine in the y-maze and significantly reversed learning and memory def ... | 2013 | 24404337 |
| eucommia ulmoides oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate er stress and hepatic lipid accumulation. | eucommia ulmoides oliver is a natural product widely used as a dietary supplement and medicinal plant. here, we examined the potential regulatory effects of eucommia ulmoides oliver extracts (eue) on hepatic dyslipidemia and its related mechanisms by in vitro and in vivo studies. eue and its two active constituents, aucubin and geniposide, inhibited palmitate-induced endoplasmic reticulum (er) stress, reducing hepatic lipid accumulation through secretion of apolipoprotein b and associated trigly ... | 2013 | 24349058 |
| eucommia ulmoides oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional chinese medicine. | eucommia ulmoides oliv. (family eucommiaceae), also known as dù-zhòng (chinese: ), tuchong (in japanese), is the sole species of the genus eucommia. the leaf, stem, and bark as well as staminate flower of eucommia ulmoides have been traditionally used to cure many diseases in china, japan, korea, among others. the aim of this review is to comprehensively outline the botanical description, ethnopharmacology, phytochemistry, biological activities, and toxicology of eucommia ulmoides and to discuss ... | 2014 | 24296089 |
| investigation into the mechanism of eucommia ulmoides oliv. based on a systems pharmacology approach. | though traditional chinese medicine (tcm) has long been playing a significant role in the maintenance of health for people in asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in tcm, such as eucommia ulmoides oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. however, its functioning mechanism is still unknown. thus it is necessary to exploit the mechanism of eucommia ulmoides o ... | 2014 | 24239601 |
| simultaneous ligand fishing and identification of human serum albumin binders from eucommia ulmoides bark using surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry. | eucommia ulmoides bark has long been known as tonic herb, however, the systematic biochemical fingerprint analysis and corresponding structural identification are inadequate so far. here we describe on-line surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry (spr-hplc-ms/ms) to fish out and identify human serum albumin (hsa) binders from e. ulmoides bark. a total of 22 hsa binders, including 4 iridoids, 11 lignans, 3 flavonoids and 4 phenolic acids, were ide ... | 2013 | 24141043 |
| effects of an aqueous extract of eucommia on articular cartilage in a rat model of osteoarthritis of the knee. | osteoarthritis is a common chronic and progressively degenerative joint condition. the stem bark of eucommia ulmoides oliver (a member of the eucommiaceae family), which is also known as du-zhong, is a traditional chinese medicine commonly used for the treatment of rheumatoid arthritis. however, the mechanisms underlying the effects of eucommia in the treatment of arthritis of the knee require further study. the present study investigated the effects of an aqueous extract of eucommia on the arti ... | 2013 | 24137247 |
| mechanism of the inhibitory effects of eucommia ulmoides oliv. cortex extracts (euce) in the ccl 4 -induced acute liver lipid accumulation in rats. | eucommia ulmoides oliv. (eu) has been used for treatment of liver diseases. the protective effects of eucommia ulmoides oliv. cortex extracts (euce) on the carbon tetrachloride- (ccl4-) induced hepatic lipid accumulation were examined in this study. rats were orally treated with euce in different doses prior to an intraperitoneal injection of 1 mg/kg ccl4. acute injection of ccl4 decreased plasma triglyceride but increased hepatic triglyceride and cholesterol as compared to control rats. on the ... | 2013 | 24027582 |
| protective effects of different extracts of eucommia ulmoides oliv. against thioacetamide-induced hepatotoxicity in mice. | a comparison of analysis in evaluating the hepatoprotective action of fractional ethanolic (f0), ethyl acetic (f1), n-butanol (f2) and aqueous (f3) extracts of e. ulmoides oliv. (euo) against thioacetamide (taa) induced hepatic damage was studied in mice. the extract (453 mg/kg-f0, 104 mg/kg-f1, 95 mg/kg-f2 and 237 mg/kg-f3 body weight, po, once daily for 15 days) restored serum marker enzymes levels to normal in taa treated mice. the biochemical biomarkers viz., total protein, albumin and total ... | 2012 | 23986971 |
| hypertensive cardiac remodeling effects of lignan extracts from eucommia ulmoides oliv. bark--a famous traditional chinese medicine. | the lignan extracts from the tree bark of eucommia ulmoides oliv., a famous traditional chinese medicine, have been demonstrated to have inhibitory effects on aldose reductase activity in spontaneously hypertensive rat myocardium. this study was aimed to investigate the hypertensive cardiac remodeling effects of the lignan extracts together with epalrestat. ten-week-old male spontaneously hypertensive rats were randomly divided into three groups (n = 12, each) and administered 100 mg/kg/d of cap ... | 2013 | 23895153 |
| heat shock factor 1 inducers from the bark of eucommia ulmoides as cytoprotective agents. | the barks of eucommia ulmoides (eucommiae cortex, eucommiaceae) have been used as a traditional medicine in korea, japan, and china to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of e. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and ... | 2013 | 23847077 |
| anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional chinese medicinal herbs. | to evaluate in vitro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential. | 2013 | 23827142 |
| histochemical study of trans-polyisoprene accumulation by spectral confocal laser scanning microscopy and a specific dye showing fluorescence solvatochromism in the rubber-producing plant, eucommia ulmoides oliver. | a microscopic technique combining spectral confocal laser scanning microscopy with a lipophilic fluorescent dye, nile red, which can emit trans-polyisoprene specific fluorescence, was developed, and unmixed images of synthesized trans-polyisoprene in situ in eucommia ulmoides were successfully obtained. the images showed that trans-polyisoprene was initially synthesized as granules in non-articulated laticifers that changed shape to fibers during laticifer maturation. non-articulated laticifers ... | 2013 | 23775438 |
| [advance in study on pharmacological effect of eucommiae folium]. | eucommia ulmoides is a valuable traditional chinese medicine, whose cortexes have long been used as medi cines. due to the scarcity of its resources, people began using its leaves instead of cortexes in medicines. eucommiae folium and its leaves have many pharmacological effects and thereby being clinically applied as genuine traditional chinese medicines. modern pharmological studies have showed that eucommiae folium leaves have such effects as blood pressure reduction, blood lipid regulation, ... | 2013 | 23717951 |
| preparative isolation and purification of seven main antioxidants from eucommia ulmoides oliv. (du-zhong) leaves using hsccc guided by dpph-hplc experiment. | seven antioxidants were purified from eucommia ulmoides oliv. leaves using hsccc guided by dpph-hplc experiment. hsccc was successfully used to separate target antioxidants by three runs with different solvent systems after d101 column chromatography fractionation. ethyl acetate-n-butanol-water (1:2:3, v/v/v) was selected as the optimum solvent system to purify geniposidic acid. ethyl acetate-ethanol-water (4:1:5, v/v/v) was used to isolate caffeic acid, chlorogenic acid and ferulic acid. while ... | 2013 | 23561146 |
| combination of preparative hplc and hsccc methods to separate phosphodiesterase inhibitors from eucommia ulmoides bark guided by ultrafiltration-based ligand screening. | phosphodiesterase (pde) inhibitors are widely used because of their various pharmacological properties, and natural products are considered the most productive source of pde inhibitors. in this work, a new ultrafiltration-high-performance liquid chromatography (hplc)-diode-array detection-mass spectrometry based ligand screening was developed for the first screening of pde inhibitors from eucommia ulmoides bark, and then the target bioactive compounds were prepared by combination of stepwise pre ... | 2013 | 23404133 |
| optimization of extraction of eucommia ulmoides polysaccharides by response surface methodology. | in this study, extraction yield of eucommia ulmoides polysaccharides was optimized by the utilization of response surface methodology (rsm). based on contour plots and variance analysis, optimum operational conditions for maximizing extraction yield were found to be extraction time 80 min, ratio of water to raw material 3, and extraction number 3. then, we investigated the protective effect of the e. ulmoides polysaccharides on the tissue peroxidative damage and abnormal antioxidant levels in is ... | 2013 | 23399217 |
| seasonal difference in antioxidant capacity and active compounds contents of eucommia ulmoides oliver leaf. | leaf of eucommia ulmoides oliver (eu) is a traditional chinese medicine and a functional food in china. antioxidant contents of eu leaves, which were collected monthly during the period of may-october in three years, were determined. samples' antioxidant capacity was characterized by dpph radical scavenging activity, hydroxyl radical scavenging activity, ferrous chelating ability, and antioxidant capacity in linoleic acid emulsion and in rapeseed oil assays. the results showed that contents of s ... | 2013 | 23377129 |