Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| combinatorial design and virtual screening of potent anti-tubercular fluoroquinolone and isothiazoloquinolone compounds utilizing qsar and pharmacophore modelling. | the virulence of tuberculosis infections resistant to conventional combination drug regimens cries for the design of potent fluoroquinolone compounds to be used as second line antimycobacterial chemotherapeutics. one of the most effective in silico methods is combinatorial design and high throughput screening by a ligand-based pharmacophore prior to experiment. the combinatorial design of a series of 3850 fluoroquinolone and isothiazoloquinolone compounds was then screened virtually by applying ... | 2018 | 29347843 |
| amplification of hsp 65 gene and usage of restriction endonuclease for identification of non tuberculous rapid grower mycobacterium. | the rapid grower mycobacteria have emerged as significant group of human pathogen amongst the runyon group iv organisms that are capable of causing infection in both the healthy and immunocompromised hosts. study aimed to identification of species amongst rapid grower non tuberculous mycobacterial isolates by polymerase chain reaction - restriction enzyme analysis (pra). analysis and comparison of results with standard biochemical tests. | 2018 | 29332650 |
| characterization of non-tuberculous mycobacterium from humans and water in an agropastoral area in zambia. | the non-tuberculous mycobacteria include those mycobacterium species that are not members of the mycobacterium tuberculosis complex, the causative agent of pulmonary tuberculosis and mycobacterium leprae. in zambia, non-tuberculous mycobacteria are gaining recognition as pathogens of public health significance. however, there is scanty information on the isolation and speciation of these organisms for better patient management, consequently reducing the burden of these infections. given the abov ... | 2018 | 29310592 |
| natural history of mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: a case report with microbiological analysis. | presence of mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs in patients with gastroesophageal disease. however, little is known about the diagnostic indications for true m. fortuitum pulmonary infection and the natural history of the disease. | 2018 | 29291713 |
| environmental screening of aeromonas hydrophila, mycobacterium spp., and pseudocapillaria tomentosa in zebrafish systems. | health monitoring systems are developed and used in zebrafish research facilities because pathogens of danio rerio such as aeromonas hydrophila, mycobacterium spp., and pseudocapillaria tomentosa have the potential to impair animal welfare and research. the fish are typically analyzed post mortem to detect microbes. the use of sentinels is a suggested way to improve the sensitivity of the surveillance and to reduce the number of animals to sample. the setting of a pre-filtration sentinel tank ou ... | 2017 | 29286459 |
| lipase-catalyzed kinetic resolution of novel antitubercular benzoxazole derivatives. | novel benzoxazole derivatives were synthesized, and their antitubercular activity against sensitive and drug-resistant mycobacterium tuberculosis strains (m. tuberculosis h37 rv, m. tuberculosis sp. 210, m. tuberculosis sp. 192, mycobacterium scrofulaceum, mycobacterium intracellulare, mycobacterium fortuitum, mycobacterium avium, and mycobacterium kansasii) was evaluated. the chemical step included preparation of ketones, alcohols, and esters bearing benzoxazole moiety. all racemic mixtures of ... | 2017 | 29274237 |
| articular sinus tract with mycobacterium fortuitum osteomyelitis after anterior cruciate ligament reconstruction: a case report. | three weeks after transphyseal anterior cruciate ligament reconstruction with a hamstring autograft, a fourteen-year-old boy presented with fevers, joint effusion, and elevated inflammatory markers. cultures from an operative debridement grew mycobacterium fortuitum, for which he received six months of antibiotics. continued drainage prompted magnetic resonance imaging, which revealed osteomyelitis of the tibial tunnel. | 2017 | 29252811 |
| mycobacterium fortuitum infection at umbilical hernioplasty site. | non tuberculous mycobacteria (ntm) are a group of rapidly growing mycobacteria and are generally considered to be of low virulence. of late, there has been an increase in incidence of infections due to these organisms. among them, mycobacterium fortuitum, m. chelonae and m. abscessus are the common species which have been identified. though they are occasionally implicated in pulmonary infections, ntm are very commonly associated with cutaneous infections, especially surgical site infections. id ... | 2017 | 29207758 |
| high rates of nontuberculous mycobacteria isolation from patients with presumptive tuberculosis in iran. | nontuberculous mycobacteria (ntm) can cause disease which can be indistinguishable from tuberculosis (tb), posing a diagnostic and therapeutic challenge, particularly in low- and middle-income settings. we aimed to investigate the mycobacterial agents associated with presumptive clinical pulmonary tb in iran. a total of 410 mycobacterial isolates, obtained between march 2014 and january 2016, from 7600 clinical samples taken from consecutive cases of presumptive diagnosis of tb were identified. ... | 2018 | 29188063 |
| [co-infection by mycobacterium fortuitum and mycobacterium tuberculosis in splenic abscesses in a patient with hiv]. | patients with hiv are susceptible to mycobacterium infection. in the case of fast-growing mycobacteria, the group to which mycobacterium fortuitum (m. fortuitum) belongs, infections have been described in the skin, lungs, lymph nodes and disseminated disease. we present the case of a 43-year-old male patient with pre-diagnosis of hiv in antiretroviral therapy, which comes as a fever, asthenia, weight loss and chronic diarrhea. abdominal tomography is performed and hepatosplenomegaly is evidenced ... | 2017 | 29177396 |
| antibiotic resistance in mycobacterium abscessus and mycobacterium fortuitum isolates from malaysian patients. | rapidly growing mycobacterial species (rgm) are increasingly being recognized as the cause of various superficial and deep infections in humans. two of the species most frequently isolated from clinical specimens are mycobacterium abscessus and mycobacterium fortuitum. both species are associated with antibiotic resistances that may complicate therapy. this paper describes the pattern of resistance to five antibiotics commonly prescribed for rgm infections, in m. abscessus and m. fortuitum isola ... | 2017 | 29171453 |
| recurrent mycobacterium fortuitum insulin injection site abscesses. | 2017 | 29168906 | |
| antibiofilm activity of nanoemulsions of cymbopogon flexuosus against rapidly growing mycobacteria. | rapidly growing mycobacteria (rgm) are opportunistic microorganisms that can cause both local and disseminated infections. when in biofilm, these pathogens become highly resistant to antimicrobials used in clinical practice. composed abundantly of polymeric substances, biofilms delay the diffusion of antimicrobials, preventing the drug from penetrating the deeper layers and having an effective action. therefore, the search for new and alternative therapeutic options has become of fundamental imp ... | 2017 | 29122674 |
| frequency of mycobacterium bovis and mycobacteria in primary immunodeficiencies. | susceptibility to mycobacterial diseases is observed in some primary immunodeficiency diseases. in this study, we aimed to evaluate mycobacterial infections in primary immunodeficiency diseases. | 2017 | 29062247 |
| molecular mechanisms of intrinsic streptomycin resistance in mycobacterium abscessus. | streptomycin, the first drug used for the treatment of tuberculosis, shows limited activity against the highly resistant pathogen mycobacterium abscessus we recently identified two aminoglycoside-acetylating genes [aac(2') and eis2] which, however, do not affect susceptibility to streptomycin. this suggests the existence of a discrete mechanism of streptomycin resistance. m. abscessus blastp analysis identified mab_2385 as a close homologue of the 3″-o-phosphotransferase [aph(3″)] from the oppor ... | 2018 | 29061744 |
| non-tuberculosis mycobacterium speciation using hplc under revised national tb control programme (rntcp) in india. | non-tuberculous mycobacteria (ntm) are ubiquitous in nature. the data on prevalence of ntm under the rntcp is scarce. many ntm species have clinical significance, and hence their identification and speciation are important. | 2018 | 28990320 |
| biological evaluation of diphenyleneiodonium chloride (dpic) as a potential drug candidate for treatment of non-tuberculous mycobacterial infections. | novel drug discovery against non-tuberculous mycobacteria is beset with a large number of challenges including the existence of myriad innate drug resistance mechanisms as well as a lack of suitable animal models, which hinders effective translation. in order to identify molecules acting via novel mechanisms of action, we screened the library of pharmacologically active compounds against non-tuberculous mycobacteria to identify such compounds. | 2017 | 28961864 |
| implantable cardiac defibrillator infections: the emerging importance of mycobacterium fortuitum. | infection is a clinically relevant complication associated with intracardiac devices. atypical mycobacteria, particularly mycobacterium fortuitum, have been increasingly implicated in cardiovascular implantable electronic device (cied) infections. we present a case of m. fortuitum cied infection in a patient with ischaemic cardiomyopathy occurring approximately 3 weeks after insertion. the recognition and adequate treatment, including device removal, tissue sampling and the determination of anti ... | 2017 | 28928258 |
| distribution of non-tuberculosis mycobacteria strains from suspected tuberculosis patients by heat shock protein 65 pcr-rflp. | the genus mycobacterium contains more than 150 species. non-tuberculosis mycobacteria (ntm) often cause extrapulmonary and pulmonary disease. mycobacteria detection at species level is necessary and provides useful information on epidemiology and facilitates successful treatment of patients. this retrospective study aimed to determine the incidence of the ntm isolates and mycobacterium tuberculosis (mtb) in clinical specimens collected from iranian patients during february 2011-december 2013, by ... | 2017 | 28855835 |
| spatio-temporal study of environmental nontuberculous mycobacteria isolated from wardha district in central india. | during the last two decades, nontuberculous mycobacteria (ntm) have gained in importance but there is still a paucity of data, particularly for environmental isolates. we studied, over a period of two years, the spatio-temporal features of ntm isolates obtained from different environmental sources in wardha district, india. a total of 1398 samples (699 each of soil and water) were tested and 170 (12.2%) yielded ntm isolates, including 123 from soil and 47 from water samples. out of 170 ntm isola ... | 2017 | 28836034 |
| mycobacterium aquaticum sp. nov., a rapidly growing species isolated from haemodialysis water. | the characterization of five iranian isolates, four from hospital haemodialysis water and one from the sputum of a patient, led to the detection of a novel mycobacterium species. the strains were characterized by mucoid colonies developing in 3-5 days at temperatures ranging from 25 to 37 °c. the biochemical test pattern was unremarkable while the hplc profile of mycolic acids resembled that of mycobacterium fortuitum. the sequences of three major housekeeping genes (16s rrna, hsp65 and rpob) we ... | 2017 | 28829035 |
| efficacy of calcium hypochlorite and ultraviolet irradiation against mycobacterium fortuitum and mycobacterium marinum. | nontuberculous mycobacteria (ntm) cause opportunistic infections with increasing frequency in immunocompromised humans. water is one of the natural sources for transmission of ntm and plays a major role in the epidemiology of ntm infections. this study evaluated the efficacy of calcium hypochlorite and ultraviolet irradiation (uv) to eliminate potentially zoonotic ntm species such as m. marinum and m. fortuitum. | 2017 | 28776533 |
| arsenic exposure impels cd4 commitment in thymus and suppress t cell cytokine secretion by increasing regulatory t cells. | arsenic is globally infamous for inducing immunosuppression associated with prevalence of opportunistic infection in exposed population, although the mechanism remains elusive. in this study, we investigate the effect of arsenic exposure on thymocyte lineage commitment and the involvement of regulatory t cells (treg) in arsenic-induced immunosuppression. male balb/c mice were exposed to 0.038, 0.38 and 3.8 ppm sodium arsenite for 7, 15 and 30 days through oral gavage. arsenic exposure promoted c ... | 2017 | 28769045 |
| association of interferon-γ receptor-1 gene polymorphism with nontuberculous mycobacterial lung infection among iranian patients with pulmonary disease. | nontuberculous mycobacteria (ntm) cause significant pulmonary infections in humans. researchers have reported an association between interferon-gamma receptor-1 (ifn-γr1 or ifngr1) deficiency and susceptibility to ntm, but the relevance of polymorphism within these genes is not yet clear. in this study, a single nucleotide polymorphism (snp), t to c, at position-56 in ntm patients with pulmonary disease was investigated. molecular identification of mycobacterium isolates was performed with hsp65 ... | 2017 | 28719321 |
| selection of biodegrading phytosterol strains. | the phytosterol-biotransforming strains were selected from mycobacterium sp., using a high concentration of β-sitosterol. the selection was made by culturing the strains in a medium enriched with 14 g β-sitosterol/l as the unique source of carbon. during 2 months, the bacterial cultures were transferred successively. the extraction of the biotransformation products was made with methanol and ethyl acetate. the qualitative and quantitative analysis was made by means of thin-layer chromatography, ... | 2017 | 28710625 |
| prosthetic valve infective endocarditis with mycobacterium fortuitum: antibiotics alone can be curative. | rapidly growing non-tuberculous mycobacteria (rgm) are a rare, often fatal cause of infective endocarditis. although surgery has been the cornerstone of rgm endocarditis therapy, we present the first documented adult case of mycobacterium fortuitum endocarditis cured with antibiotic therapy. | 2017 | 28688832 |
| discovery of novel antimycobacterial drug therapy in biofilm of pathogenic nontuberculous mycobacterial keratitis. | the potential of slow-growing mycobacteria to form biofilms in human tissues contributes to the problem of establishing an effective treatment strategy. the purpose of this study was to examine new antibiotic strategies to enhance current treatment options for these infections. | 2017 | 28662943 |
| acetone leaf extracts of some south african trees with high activity against escherichia coli also have good antimycobacterial activity and selectivity index. | tuberculosis is a world-wide problem affecting humans and animals. there is increasing development of resistance of the pathogens to current antimycobacterial agents. many authors have investigated activities of extracts and isolated compounds from plants. the traditional uses of plants have frequently been the criterion to select plants investigated. in this contribution, we investigate whether plant extracts with very good activity against escherichia coli may also be active against mycobacter ... | 2017 | 28629354 |
| antimicrobial susceptibility testing and molecular characterization of mycobacterium fortuitum isolates in china. | we performed molecular identification of clinical isolates of mycobacterium fortuitum (m. fortuitum) and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical m. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. the results showed that moxifloxacin had the highest in vitro activity against m. fortuitum, and most m. fortuitum isolates were resistant to clarithromycin and linezolid in china. the los ... | 2017 | 28549494 |
| draft genome sequence of mycobacterium boenickei cip 107829. | mycobacterium boenickei is a rapidly growing mycobacterium isolated for the first time from a leg wound in the united states. its 6,506,908-bp draft genome exhibits a 66.77% g+c content, 6,279 protein-coding genes, and 59 predicted rna genes. in silico dna-dna hybridization confirms its assignment to the mycobacterium fortuitum complex. | 2017 | 28473389 |
| septicemia and pneumonia due to mycobacterium fortuitum infection in a patient with extronodal nk/t-cell lymphoma, nasal type: a case report. | mycobacterium fortuitum (m.fortuitum) is one of the rapidly growing nontuberculous mycobacterium (ntm) that is widespread in the environment. m.fortuitum can cause different types of disease including pulmonary disease, lymphadenitis, cutaneous disease, and disseminated disease. however, the infection presenting as septicemia is exceedingly rare. | 2017 | 28471978 |
| mutual interaction enables the mycobacterial plasmid pal5000 origin binding protein repb to recruit repa, the plasmid replicase, to the origin. | the mycobacterium fortuitum plasmid, pal5000, is the most-studied member of a family of plasmids that are found in actinobacteria. its replication is brought about by the combined action of two plasmid-encoded replication proteins, repa and repb. repb has earlier been shown to be a sigma factor homologue that possesses origin-binding activity. the mechanism by which repa functions, and its relationship with repb, if any, has not been explored yet. in this study, we show that repa shares a common ... | 2017 | 28430099 |
| a strong and fortuitous case of dyspnea. | a 48 year-old man with no past medical history was sent to our emergency department (ed); from a primary care clinic for hypertensive urgency of 200/130. the man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. of note, he emigrated from honduras twenty years ago. blood pressure normalized with administration of lasix in the ed. physical exam revealed rales in lung ... | 2017 | 28414672 |
| species-specific risk factors, treatment decisions, and clinical outcomes for laboratory isolates of less common nontuberculous mycobacteria in washington state. | nontuberculous mycobacteria (ntm) are a diverse group of environmental organisms that infrequently cause human disease. understanding of the epidemiologic and clinical characteristics associated with ntm disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species. | 2017 | 28387523 |
| atypical mycobacterial infections of the upper extremity: becoming more atypical? | background: atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. historically, these infections are associated with marine-related injury and/or immune dysfunction. our institution has successfully diagnosed and treated an increasing number of these infections. the objective of this study is to review our experience with these rare infections and verify the developing trends encountered. methods: a retrospective review was performed for ... | 2017 | 28344532 |
| mycobacterium fortuitum bloodstream infection in a very low birth weight preterm neonate. | mycobacterium fortuitum is a rapidly growing mycobacterium species that is a rare cause of disease, primarily in immunocompromised patients. we present a preterm very low birth weight neonate who developed m. fortuitum bloodstream infection, where 16s rdna sequencing allowed accurate identification. cure was achieved by line removal and adjuvant combination treatment with amikacin, ciprofloxacin and clarithromycin. | 2017 | 28333709 |
| port-site infections by nontuberculous mycobacterium: a retrospective clinico-microbiological study. | port-site infection (psi) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (ls). it neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. psis are preventable with appropriate preoperative, intraoperative, and postoperative measures. atypical mycobacterium is most commonly associated with nonhealing postlaparoscopic wound infections, causing outbr ... | 2017 | 28317802 |
| antimicrobial susceptibility testing of rapidly growing mycobacteria isolated in japan. | difficult-to-treat infections caused by rapidly growing mycobacteria (rgm) are increasingly observed in clinical settings. however, studies on antimicrobial susceptibilities and effective treatments against rgm in japan are limited. | 2017 | 28270102 |
| in vitro activity of bedaquiline against nontuberculous mycobacteria in china. | the main goal of our study was to evaluate in vitro drug susceptibility of bedaquiline against six prevalent pathogenic nontuberculous mycobacteria (ntm) diseases in china. in addition, we investigated the potential molecular mechanism contributing to the bedaquiline resistance in these different ntm species. for slowly growing mycobacteria (sgm), bedaquiline exhibited the highest activity against mycobacterium avium, the mic50 and mic90 were 0.03 and 16 mg/l, respectively. of rapidly growing my ... | 2017 | 28242674 |
| microbiological quality and occurrence of nontuberculous mycobacteria in fresh-squeezed orange juice samples purchased from street vendors in mexico city. | nontuberculous mycobacteria (ntm) are potentially pathogenic agents commonly found in a natural ecosystem. for this reason, food is considered another source of ntm transmission for humans. the aims of this study were to evaluate the microbiological quality and the occurrence of ntm in fresh-squeezed orange juice samples purchased from street vendors. all 102 samples analyzed were positive for aerobic mesophilic bacteria (amb), with limits ranging from 1.8 to 6.2 log cfu/ml. a total of 55 (54%), ... | 2016 | 28221956 |
| pulmonary nontuberculous mycobacteria-associated deaths, ontario, canada, 2001-2013. | survival implications of nontuberculous mycobacterial pulmonary disease (ntm-pd) and ntm pulmonary isolation without disease (ntm-pi) are unclear. to study deaths associated with ntm-pd and ntm-pi and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined ntm-pd or ntm-pi diagnosed during 2001-2013 in ontario, canada. we used propensity score matching and cox proportional hazards models to compare survival. among 9,681 ntm-pd ... | 2017 | 28221106 |
| detection of mycobacterium chelonae, mycobacterium abscessus group, and mycobacterium fortuitum complex by a multiplex real-time pcr directly from clinical samples using the bd max system. | a new multiplex pcr test was designed to detect mycobacterium chelonae, mycobacterium abscessus group, and mycobacterium fortuitum complex on the bd max system. a total of 197 clinical samples previously submitted for mycobacterial culture were tested using the new protocol. samples were first treated with proteinase k, and then each sample was inoculated into the bd max sample buffer tube. extraction and multiplex pcr were performed by the bd max system, using the bd max exk tna-3 extraction ki ... | 2017 | 28190461 |
| ocular mycobacteriosis-dual infection of m. tuberculosis complex with m. fortuitum and m. bovis. | we report unfavorable outcome in a patient with subretinal granuloma caused by dual infection of mycobacterium tuberculosis complex with mycobacterium fortuitum and mycobacterium bovis in an immunosuppressed, non-hiv patient. we did a systematic review of literature on dual infection due to m. tuberculosis and m. fortuitum via medline and pubmed and could not find any case reported of causing this kind of dual infection in the eye. | 2017 | 28091937 |
| rapidly growing mycobacteria. | rapidly growing mycobacteria (rgm) compose approximately one-half of the currently validated mycobacterial species and are divided into six major groups, including the mycobacterium fortuitum group, m. chelonae/m. abscessus complex, m. smegmatis group, m. mucogenicum group, m. mageritense/m. wolinskyi, and the pigmented rgm. this review discusses each group and highlights the major types of infections associated with each group. additionally, phenotypic and molecular laboratory identification me ... | 2017 | 28084211 |
| anti-mycobacterial function of macrophages is impaired in a diet induced model of type 2 diabetes. | type 2 diabetes (t2d) is one of the major risk factors for tuberculosis (tb). in this study, a diet induced murine model of t2d (dimt2d) was developed and characterized in the context of metabolic, biochemical and histopathological features following diet intervention. mycobacterial susceptibility was investigated using mycobacterium fortuitum as a surrogate. phagocytic capability of alveolar macrophages and resident peritoneal macrophages were determined by in vitro assays using mycolic acid co ... | 2017 | 28061952 |
| a case of surgical site infection caused by mycobacterium fortuitum, following herniorrhaphy. | rapidly growing mycobacteria (rgm) are opportunistic pathogens found in the environment. mycobacterium fortuitum, m. chelonae and m.abscessus are the important human pathogens of this group. they cause wound infections, disseminated cutaneous disease, pulmonary infection in patients with cystic fibrosis or bronchiectasis, bone and joint infections and keratitis. infections due to these non-tuberculous mycobacteria (ntm) are increasingly reported. post laparoscopic wound infections, mesh site inf ... | 2016 | 28050369 |
| identification of nontuberculous mycobacteria by high-performance liquid chromatography from patients in tehran. | the genus mycobacterium contains over 140 species comprises pathogenic and nonpathogenic strains. nontuberculous mycobacteria (ntm) causing clinical disease have become increasingly common and more diverse. widespread features of ntm infection can make the diagnosis difficult. precise species-level detection can aid in distinguishing environmental contamination from actual infection and, furthermore, can assist in making a choice of antimicrobial therapy. | 2016 | 28043562 |
| identification of different subtypes of rapid growing atypical mycobacterium from water and soil sources: using pcr-rflp using hsp65 and rrna 16s-23s genes. | nontuberculosis mycobacteria (ntm) are a diverse group of microorganisms that cause a variety of diseases in humans including skin, respiratory, and gastrointestinal tract infection. generally, ntm are classified into two categories: rapid (<7days) and slow growing (>7days). in this study, we aimed to investigate ntm frequency and prevalence in environmental samples. additionally, we tried to identify various subtypes of isolated rapid growing mycobacteria (rgm). | 2016 | 28043561 |
| the importance of single nucleotide polymorphisms in interferon gamma receptor-1 gene in pulmonary patients infected with rapid grower mycobacterium. | interferon gamma (ifn-γ) plays a key role in protective immune response against mycobacterial infection. ifn-γ excretes its antimycobacterial effectors mechanisms by activation of macrophages and dendritic cells via interaction with its receptor complex, that is, a ligand-binding subunit [ifn-γ receptor (ifngr)1] and an accessory subunit (ifngr2) on the cell surface. it has been shown that individuals with complete or partial ifngr1 receptor deficiency are highly susceptible to infection by nont ... | 2016 | 28043560 |
| frequency of mycobacterial infections in retailed fish in karaj: an iranian perspective. | mycobacterium species comprise one of the most frequently-reported causative agents in granulomatous lesions of fish. also, mycobacteria have been documented as fish-born zoonoses. ornamental aquaria, commercial aquaculture, and wild fisheries therefore produce a potential risk of infection for humans through physical contact and consumption of fishes. a number of fish mycobacteriosis and fish-born zoonotic cases have been reported to date in iran. | 2016 | 28043553 |
| development of the food supplement nyaditum resae as a new tool to reduce the risk of tuberculosis development. | nyaditum resae (nr) is a galenic preparation of heat-killed mycobacterium manresensis (hkmn). this is a new species that belongs to the mycobacterium fortuitum complex, and it is present in drinking water-thus, regulatorily speaking, it is considered a food supplement. preclinical studies in the murine model of active tuberculosis (tb) in the c3heb/fej strain have demonstrated that daily administration of nr containing 10(3)-10(6)hkmn for 14days was able to stop the progression toward active tb ... | 2016 | 28043488 |
| complicated skin and soft tissue infection with mycobacterium fortuitum following excision of a sebaceous cyst in taiwan. | mycobacterium fortuitum group (m. fortuitum), also known as rapidly growing mycobacteria, can cause pyogenic infections in human beings, most commonly in immunocompromised patients. herein, we present a 40-year-old immunocompetent male patient who underwent planned excision of a sebaceous cyst in the abdominal wall. he suffered from tender erythematous lesions with purulent discharge around the healing wound that developed 2 weeks after surgery. gram stain, bacterial and fungal culture results o ... | 2016 | 28036317 |
| granulomatous lobular mastitis secondary to mycobacterium fortuitum. | granulomatous lobular mastitis is a rare inflammatory disease of the breast of unknown etiology. most present as breast masses in women of child-bearing age. a 29-year-old female presented with a swollen, firm and tender right breast, initially misdiagnosed as mastitis. core needle biopsy revealed findings consistent with granulomatous lobular mastitis, and cultures were all negative for an infectious etiology. she was started on steroid therapy to which she initially responded well. a few weeks ... | 2016 | 28035314 |
| optimizing of a protein extraction method for mycobacterium tuberculosis proteome analysis using mass spectrometry. | a critical step in proteomic analyses comprises the implementation of a reliable cell lysis method with high yields of qualitative proteins. in mycobacteria, the protein extraction step is often hampered by the thick waxy cell wall which is rich in mycolic acids. harsh disruption techniques to release proteins from the cells are thus required. here, we demonstrate an optimized protein extraction procedure for mycobacterium tuberculosis (mbt) that results in protein extracts that are useful for a ... | 2016 | 27984057 |
| cutaneous atypical mycobacterial infection with mycobacterium fortuitum arising after endovenous radiofrequency ablation. | 2016 | 27981216 | |
| drug susceptibility of rapid and slow growing non-tuberculous mycobacteria isolated from symptomatics for pulmonary tuberculosis, central india. | non-tuberculous mycobacteria (ntm) are emerging as important pathogens. their treatment also differs from that of mycobacterium tuberculosis. in india, any datum on them is scarce as species identification and drug susceptibility are not performed in most laboratories. susceptibility also differs from one geographic area to another, and in our country, there are no data even to guide the clinicians to start treatment empirically. | 2017 | 27934821 |
| nontuberculous mycobacteria in children: a focus on bloodstream infections. | nontuberculous mycobacteria (ntm) are ubiquitous organisms with variable disease-causing potential. bloodstream infections caused by ntm in children are poorly described. | 2017 | 27918379 |
| prevalence of nontuberculous mycobacteria isolated from environmental samples in iran: a meta-analysis. | while the most nontuberculous mycobacteria (ntms) species are considered as opportunistic pathogens, some of them are related to several human infections. it is believed that environment is the main source for these infections. distribution and scattering pattern of ntms has not been well studied in iran and a few studies about this subject have been done, so the aim of this study was to determine prevalence of ntms in environmental samples from iran. | 2016 | 27904603 |
| mycobacterium fortuitum empyema associated with an indwelling pleural catheter: case report and review of the literature. | mycobacterium fortuitum is a rapidly growing mycobacterium (rgm) that is an uncommon cause of healthcare-associated infections. the most common infections caused by m. fortuitum include skin, soft tissue, and catheter-related infections. although occasionally cultured from sputum samples, m. fortuitum is a rare cause of pulmonary disease. we report a case of m. fortuitum empyema associated with an infected pleural catheter and review m. fortuitum pulmonary infections. | 2017 | 27890417 |
| the performance of interferon-gamma release assay in nontuberculous mycobacterial diseases: a retrospective study in china. | the interferon-gamma release assay (igra) is more specific than the tuberculin skin test to discriminate between tuberculosis (tb) and nontuberculous mycobacterial (ntm) diseases. here we performed a retrospective study to evaluate the performance of the t-spot.tb in patients with ntm diseases. | 2016 | 27887611 |
| use of an experimental model to evaluate infection resistance of meshes in abdominal wall surgery. | staphylococcal species are the most common organisms causing prosthetic mesh infections, however, infections due to rapidly growing mycobacteria are increasing. this study evaluates the resistance of biomaterial for abdominal wall prostheses against the development of postoperative infection in a rat model. | 2016 | 27884340 |
| prevalence and species spectrum of both pulmonary and extrapulmonary nontuberculous mycobacteria isolates at a tertiary care center. | nontuberculous mycobacteria (ntm) infection associated with pulmonary and extrapulmonary disease has been increasing globally. despite an increase in incidence rate of ntm infection, its prevalence, species diversity, and circulation pattern in india is largely unknown. this study sought to investigate the overall burden and diversity of ntm among both pulmonary and extrapulmonary clinical isolates from a northern indian population. | 2016 | 27847012 |
| resistance profile of strains of mycobacterium fortuitum isolated from clinical specimens. | 2017 | 27832239 | |
| mycobacterium fortuitum infection of the scalp after a skin graft. | mycobacterium fortuitum is a non-tuberculous mycobacterium found in the soil and water of most regions of the world, and it can cause disease in immunocompetent and immunocompromised hosts. we present a 52-year-old man who developed a scalp abscess under a free flap for cranium coverage after a motor vehicle accident. culture of material drained from the abscess grew m. fortuitum. | 2016 | 27797799 |
| mycobacteria in aquarium fish: results of a 3-year survey indicate caution required in handling pet-shop fish. | fish are commonly infected with non-tuberculous mycobacteria (ntm), which should be regarded as potential pathogens when handling aquarium fish and equipment. this study examined 107 aquarium fish from pet shops. cultivation of the fish samples using different selective media was conducted for identification of ntm. isolates were identified using the genotype mycobacterium common mycobacteria and additional species assays, sequencing of the 16s rrna and rpob genes, and real-time pcr assay for id ... | 2016 | 27747884 |
| non-tuberculous mycobacteria mimic of mdr-tb infection in pott's disease. | a 34 year-old woman presented with history of progressive back pain which was diagnosed as pott's disease with recurrent paravertebral abscess, and had received a total of 23 months of antitubercular treatment for lumbar infection. the patient was non-responsive to treatment and was referred to a higher centre where the infection was finally identified as non-tuberculous mycobacterium (mycobacterium fortuitum) by genotypic testing. the drugs were initiated according to results of drug susceptibi ... | 2016 | 27664225 |
| commercial disinfectants during disinfection process validation: more failures than success. | disinfection process validation is mandatory before introduction of a new disinfectant in hospital services. commercial disinfection brands often question existing hospital policy claiming greater efficacy and lack of toxicity of their products. inadvertent inadequate disinfection leads to morbidity, patient's economic burden, and the risk of mortality. | 2016 | 27656441 |
| antimycobacterial activity and low cytotoxicity of leaf extracts of some african anacardiaceae tree species. | treatment of tuberculosis (tb) is a challenge because of multidrug-resistant and extremely drug-resistant strains of mycobacterium tuberculosis. plant species contain antimicrobial compounds that may lead to new anti-tb drugs. previous screening of some tree species from the anacardiaceae family revealed the presence of antimicrobial activity, justifying further investigations. leaf extracts of 15 anacardiaceae tree species were screened for antimycobacterial activity using a twofold serial micr ... | 2016 | 27619156 |
| identification of antimicrobial activity among new sulfonamide metal complexes for combating rapidly growing mycobacteria. | mycobacteriosis is a type of infection caused by rapidly growing mycobacteria (rgm), which can vary from localized illness, such as skin disease, to disseminated disease. amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem and sulfamethoxazole are antimicrobial drugs chosen to treat such illnesses; however, not all patients obtain the cure. the reason why the treatment does not work for those patients is related to the fact that some clinical strains present resistance to t ... | 2016 | 27567903 |
| antibiofilm effect of antimicrobials used in the therapy of mycobacteriosis. | rapidly growing mycobacteria (rgm) are opportunistic pathogens found in the environment. when in biofilms, mycobacteria is highly resistant to antibacterial treatments. the purpose of this study is to evaluate the antibiofilm activity of antimicrobials commonly used in therapy against mycobacteria. the antimicrobial susceptibility of mycobacterium abscessus, mycobacterium fortuitum and mycobacterium massiliense was determined in planktonic and sessile populations. the antimicrobials amikacin, ci ... | 2016 | 27554273 |
| concurrent nontuberculous mycobacteria infection and high-grade anterior mediastinal extraskeletal osteosarcoma (esos): is there a connection? | background extraskeletal osteosarcomas (esos) of the mediastinum are extremely rare and may present with concurrent nontuberculous mycobacteria infection. case report we present the second documented case of high-grade anterior mediastinal extraskeletal osteosarcoma in a 59-year-old man with a history of treated, latent tuberculosis (tb). sputum samples grew mycoplasma avium complex and mycobacterium fortuitum. imaging showed a right-sided 7.6 cm mass with compression of the main bronchus. subse ... | 2016 | 27539718 |
| multiple lumps in the breast due to mycobacterium fortuitum. | although breast tissue is the most resistant to tuberculosis, its incidence is increasing worldwide. high incidence of breast tuberculosis is presumed in india. the rapidly growing nontubercular mycobacteria, such as mycobacterium fortuitum and mycobacterium chelonae, are of increasing clinical importance because infections due to these organisms are often hospital acquired. the true incidence of m. fortuitum is unknown but it has been estimated to be between 4 and 6 cases per one million people ... | 2016 | 27451824 |
| drug susceptibility testing of rapidly growing mycobacteria in extrapulmonary tuberculosis. | there has been an increasing awareness of the rapidly growing mycobacteria (rgm), of which numerous species and phylogenetic groups are clearly established human pathogens. it is important to appropriately distinguish rgm from other mycobacteria, as first-line antituberculous drugs are ineffective for their treatment. variability in susceptibility of rgm is seen in relation to species, different geographical areas, and time. therefore, we conducted a study to speciate the isolates of rgm and per ... | 2016 | 27451822 |
| clinical and microbiological profile of non-tuberculous mycobacterial endophthalmitis-experience in a tertiary eye care centre in southern india. | endophthalmitis caused by non-tuberculous mycobacteria (ntm) is a rare condition seen after surgery and trauma. this study reports a retrospective, consecutive, non-comparative case series of 5 patients referred to l. v. prasad eye institute, hyderabad, and diagnosed with culture-proven ntm endophthalmitis between january 2004 and april 2015. data collected included demographic information, presenting features, microbiology investigation, treatment course, and final visual outcome. | 2016 | 27439781 |
| multistate us outbreak of rapidly growing mycobacterial infections associated with medical tourism to the dominican republic, 2013-2014(1). | during 2013, the maryland department of health and mental hygiene in baltimore, md, usa, received report of 2 maryland residents whose surgical sites were infected with rapidly growing mycobacteria after cosmetic procedures at a clinic (clinic a) in the dominican republic. a multistate investigation was initiated; a probable case was defined as a surgical site infection unresponsive to therapy in a patient who had undergone cosmetic surgery in the dominican republic. we identified 21 case-patien ... | 2016 | 27434822 |
| mycobacterium fortuitum infections in surgical wounds. | 2009 | 27408208 | |
| the impact of protein extraction protocols on the performance of currently available maldi-tof mass spectrometry for identification of mycobacterial clinical isolates cultured in liquid media. | protein extraction step is particularly important for identification of mycobacterial isolates by maldi-tof mass spectrometry (ms) because of its thick and solid cell wall. this study compared the performance of maldi-tof ms for identification of mycobacterial clinical isolates cultured in liquid media between heating-based protocol and non-heating protocol. | 2016 | 27380997 |
| comparative genomics and proteomic analysis of four non-tuberculous mycobacterium species and mycobacterium tuberculosis complex: occurrence of shared immunogenic proteins. | the esx and pe/ppe families of proteins are among the most immunodominant mycobacterial antigens and have thus been the focus of research to develop vaccines and immunological tests for diagnosis of bovine and human tuberculosis, mainly caused by mycobacterium bovis and mycobacterium tuberculosis, respectively. in non-tuberculous mycobacteria (ntm), multiple copies of genes encoding homologous proteins have mainly been identified in pathogenic mycobacterium species phylogenically related to myco ... | 2016 | 27375559 |
| mycobacterium lutetiense sp. nov., mycobacterium montmartrense sp. nov. and mycobacterium arcueilense sp. nov., members of a novel group of non-pigmented rapidly growing mycobacteria recovered from a water distribution system. | from our recent survey of non-pigmented rapidly growing mycobacteria in the parisian water system, three groups of isolates (taxons 1-3) corresponding to possible novel species were selected for taxonomic study. the three taxa each formed creamy white, rough colonies, had an optimal growth temperature of 30 °c, hydrolyzed tween 80, were catalase-positive at 22 °c and expressed arylsulfatase activity. all three were susceptible to amikacin, ciprofloxacin and tigecycline. the three taxa produced s ... | 2016 | 27375118 |
| analysis of pulmonary non-tuberculous mycobacterial infections after lung transplantation. | non-tuberculous mycobacteria (ntm) are important pathogens in lung transplant recipients. this study describes the spectrum of ntm respiratory tract infections and examines the association of ntm infections with lung transplant complications. | 2016 | 27368989 |
| [urinary infection due to mycobacterium fortuitum in a patient with hiv infection]. | 2016 | 27262572 | |
| microbial pathogens in source and treated waters from drinking water treatment plants in the united states and implications for human health. | an occurrence survey was conducted on selected pathogens in source and treated drinking water collected from 25 drinking water treatment plants (dwtps) in the united states. water samples were analyzed for the protozoa giardia and cryptosporidium (epa method 1623); the fungi aspergillus fumigatus, aspergillus niger and aspergillus terreus (quantitative pcr [qpcr]); and the bacteria legionella pneumophila (qpcr), mycobacterium avium, m. avium subspecies paratuberculosis, and mycobacterium intrace ... | 2016 | 27260619 |
| ala-pdt combined with antibiotics for the treatment of multiple skin abscesses caused by mycobacterium fortuitum. | atypical mycobacterial skin infection is rare in clinical practice. because atypical mycobacteria are highly hydrophobic, the permeability of the outer membrane of the bacterial wall is very low, which makes it difficult for drugs to cross the barrier. additionally, atypical mycobacteria are resistant to many drugs, and thus, infection tends to last for a long time and become recurrent and difficult to treat. thus, it is very important to find new, more effective treatment methods. mycobacterium ... | 2016 | 27235279 |
| analysis of dna gyra gene mutation in clinical and environmental ciprofloxacin-resistant isolates of non-tuberculous mycobacteria using molecular methods. | during the past several years, nontuberculous mycobacteria (ntm) have been reported as some of the most important agents of infection in immunocompromised patients. | 2016 | 27217921 |
| isolation of nontuberculous mycobacteria from the environment of ghanian communities where buruli ulcer is endemic. | this study aimed to isolate nontuberculous mycobacterial species from environmental samples obtained from some selected communities in ghana. to optimize decontamination, spiked environmental samples were used to evaluate four decontamination solutions and supplemented media, after which the best decontamination solution and media were used for the actual analysis. the isolates obtained were identified on the basis of specific genetic sequences, including heat shock protein 65, is2404, is2606, r ... | 2016 | 27208141 |
| magneto-actuated immunoassay for the detection of mycobacterium fortuitum in hemodialysis water. | this paper addresses a sensitive method for the detection of mycobacteria in hemodialysis water samples based on a magneto-actuated immunoassay with optical readout. in this approach, micro (2.8μm) sized magnetic particles were modified with an antibody against the lipoarabinomannan (lam) located in the mycobacterial cell wall. the system relies on the immunocapturing of the mycobacteria with the tailored antilam magnetic particles to pre-concentrate the bacteria from the hemodialysis samples th ... | 2016 | 27130087 |
| inverse correlation between salt tolerance and host-adaptation in mycobacteria. | the genus mycobacterium includes host-adapted organisms regarded as obligate and opportunistic pathogens and environmental organisms. factors contributing to this wide range of adaptations are poorly known. | 2016 | 27129386 |
| [establishment of multiplex pcr method for rapid detection of nontuberculous mycobacteriums infection in the hand]. | to establish a multiplex polymerase chain reaction (mpcr) method with high sensitivity and specificity for rapid detection of common nontuberculous mycobacterium(ntm) infection in the hand. | 2016 | 27095780 |
| draft genome sequence of mycobacterium fortuitum isolated from murine brain. | mycobacterium fortuitumsubsp.fortuitumatcc 6841 is a type and standard laboratory testing quality control strain. we report here the completed draft genome sequence for a strain isolated from the brains ofm. fortuitum-infected mice. | 2016 | 27034497 |
| whole-genome sequencing and comparative analysis of mycobacterium brisbanense reveals a possible soil origin and capability in fertiliser synthesis. | mycobacterium brisbanense is a member of mycobacterium fortuitum third biovariant complex, which includes rapidly growing mycobacterium spp. that normally inhabit soil, dust and water, and can sometimes cause respiratory tract infections in humans. we present the first whole-genome analysis of m. brisbanense um_wwy which was isolated from a 70-year-old malaysian patient. molecular phylogenetic analyses confirmed the identification of this strain as m. brisbanense and showed that it has an unusua ... | 2016 | 27031249 |
| isolation and identification of nontuberculous mycobacteria from hospitalized patients and drinking water samples--examination of their correlation by chemometrics. | nontuberculous mycobacteria (ntm) have been found to be widely dispersed in the environment and are being considered potentially pathogenic for humans and animals, while reports of their human to human transmission are absent. water and aerosols are potential transmission modes of ntm to humans. hospitalized patients with ntm infections were studied together with drinking water samples from their respective residence areas during 2003-2013. cluster analysis and factor analysis were used to analy ... | 2016 | 27021690 |
| epidemiology of nontuberculous mycobacteria isolations among central north carolina residents, 2006-2010. | nontuberculous mycobacteria (ntm) are environmental mycobacteria associated with a range of infections. reports of ntm epidemiology have primarily focused on pulmonary infections and isolations, however extrapulmonary infections of the skin, soft tissues and sterile sites are less frequently described. | 2016 | 26997636 |
| epidemiology of rapidly growing mycobacteria bloodstream infections. | rapidly growing mycobacteria (rgm) bloodstream infections (bsi) are an emerging problem often associated with therapeutic challenges. we review the epidemiology, treatment and outcomes over a 5-year period of a heterogeneous group presenting to our institution with rgm bsi. | 2016 | 26992253 |
| mycobacterium fortuitum induces a20 expression that impairs macrophage inflammatory responses. | mycobacterium fortuitum is a rapidly growing mycobacterium that has been regarded as an etiological agent of a variety of human infections. however, little is known about the host inflammatory responses and the molecular mechanisms by which mf-induced inflammation is regulated in macrophages. in this study, we report that mf infection leads to the induction of an anti-inflammatory molecule, a20 (also known as tnfaip3), which is essential for the regulation of mf-induced inflammatory responses in ... | 2016 | 26940588 |
| deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients. | complete interferon-γ receptor 1 (ifn-γr1) deficiency is a primary immunodeficiency causing predisposition to severe infection due to intracellular pathogens. only 36 cases have been reported worldwide. the purpose of this article is to describe a large novel deletion found in 3 related cases, which resulted in the complete removal of the ifngr1 gene. | 2016 | 26931784 |
| patient report and review of rapidly growing mycobacterial infection after cardiac device implantation. | mycobacterial infections resulting from cardiac implantable electronic devices are rare, but as more devices are implanted, these organisms are increasingly emerging as causes of early-onset infections. we report a patient with an implantable cardioverter-defibrillator pocket and associated bloodstream infection caused by an organism of the mycobacterium fortuitum group, and we review the literature regarding mycobacterial infections resulting from cardiac device implantations. thirty-two such i ... | 2016 | 26890060 |
| [frequency and clinical relevance of rapidly growing mycobacterium isolated from respiratory samples]. | to assess the frequency and clinical relevance of rapidly growing mycobacterium (rgm) isolates in a tuberculosis referral center in beijing, china. | 2016 | 26879615 |
| molecular identification of clinical isolates of mycobacterium fortuitum by random amplified polymorphic dna (rapd) polymerase chain reaction and eric pcr. | non tuberculous mycobacteria (ntm) are of importance now-a-days due to their increasing virulence outbreaks and emerging antibiotic resistance. since the most common ntm in iran is reportedly mycobacterium fortuitum, the present study was designed with the aim of molecular identification of clinical isolates of m. foruitum to analyse their heterogeneity. | 2015 | 26816886 |
| identification of mycobacterium species following growth detection with the bactec mgit 960 system by dna line probe assay. | the tuberculosis and infections caused by nontuberculous mycobacterial (ntm) species are increasing in patients presented with respiratory illness, and it is crucial to document the epidemiology of these infections. | 2014 | 26786328 |
| mycobacterium fortuitum causing infection of a biventricular pacemaker/implantable cardioverter defibrillator. | increased utilization of cardiovascular implantable electronic devices (cied) has seen a corresponding rise in related infections. non-tuberculosis mycobacteria (ntm) are rarely the cause. treatment involves susceptibilities, antimicrobials, and device removal. this study presents a patient who underwent a biventricular implantable cardioverter defibrillator upgrade with a multi-drug resistant mycobacterium fortuitum located at the pocket site and a lead infection. | 2012 | 26785629 |