Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| cilostazol inhibits the expression of hnrnp a2/b1 and cytokines in human dermal microvascular endothelial cells. | hnrnp a2/b1 has been identified as a target antigen of anti-endothelial cell iga antibody in patients with behçet's disease (bd). in addition, increased expression of cellular hnrnp a2/b1 is stimulated by streptococcus sanguinis or the sera from patients with bd. we aimed to investigate the effects of cilostazol on the expression of hnrnp a2/b1 and chemokines in human dermal microvascular endothelial cells (hdmecs). | 2017 | 28850024 |
| behçet disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial hsp-65, a putative trigger. | autoimmune and dysimmune inflammatory mechanisms on a genetically susceptible background are implicated in the etiology of behçet's disease (bd). heat-shock protein-65 (hsp-65) derived from streptococcus sanguinis was proposed as a triggering factor based on its homology with human hsp-60. however, none of the autoantigens identified so far in sera from bd share common epitopes with bacterial hsp-65 or has a high prevalence. here, we report that sera from bd patients are immunoreactive against f ... | 2017 | 28844827 |
| impact of a 7-day field training on oral health condition in japan ground self-defense force personnel. | in the japan ground self-defense force (jgsdf), personnel periodically perform intensive training that mimics the conditions seen in battle and during natural disasters. military training involves intensive, stressful conditions, and changes in immune responses have been found in personnel following training. good oral condition is important for military personnel to fulfill their duties; however, they have difficulty performing daily oral care under training conditions. in this study, we invest ... | 2017 | 28810984 |
| fluoride depletes acidogenic taxa in oral but not gut microbial communities in mice. | fluoridation of drinking water and dental products prevents dental caries primarily by inhibiting energy harvest in oral cariogenic bacteria (such as streptococcus mutans and streptococcus sanguinis), thus leading to their depletion. however, the extent to which oral and gut microbial communities are affected by host fluoride exposure has been underexplored. in this study, we modeled human fluoride exposures to municipal water and dental products by treating mice with low or high levels of fluor ... | 2017 | 28808691 |
| antimicrobial efficacy of triple antibiotic-eluting polymer nanofibers against multispecies biofilm. | the elimination of microbial flora in cases of immature permanent teeth with necrotic pulp is both key and a challenging goal for the long-term success of regenerative therapy. recent research has focused on the development of cell-friendly intracanal drug delivery systems. this in vitro study aimed to investigate the antimicrobial action of 3-dimensional (3d) tubular-shaped triple antibiotic-eluting nanofibrous constructs against a multispecies biofilm on human dentin. polydioxanone polymer sol ... | 2017 | 28778504 |
| ecological effect of arginine on oral microbiota. | dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. however, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the m ... | 2017 | 28775282 |
| anti-caries effects of dental adhesives containing quaternary ammonium methacrylates with different chain lengths. | the objectives of this study were to investigate the effects of dental adhesives containing quaternary ammonium methacrylates (qams) with different alkyl chain lengths (cl) on ecological caries prevention in vitro. five qams were synthesized with a cl = 3, 6, 9, 12, and 16 and incorporated into adhesives. micro-tensile bond strength and surface charge density were used to measure the physical properties of the adhesives. the proportion change in three-species biofilms consisting of streptococcus ... | 2017 | 28773004 |
| novel dental adhesive with biofilm-regulating and remineralization capabilities. | the mechanical properties and anti-caries effect of a novel anti-caries adhesive containing poly (amidoamine) dendrimer (pamam) and dimethylaminododecyl methacrylate (dmaddm) were investigated for the first time. microtensile bond strength and surface charge density were measured for the novel anti-caries adhesives. streptococcus mutans, streptococcus sanguinis, and streptococcus gordonii were chosen to form three-species biofilms. lactic acid assay, mtt (3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphen ... | 2017 | 28772391 |
| bacterial attachment on titanium surfaces is dependent on topography and chemical changes induced by nonthermal atmospheric pressure plasma. | here, we investigated the antibacterial effects of chemical changes induced by nonthermal atmospheric pressure plasma (ntapp) on smooth and rough ti. the morphologies of smooth and rough surfaces of ti were examined using scanning electron microscopy (sem). both ti specimens were then treated for 10 min by ntapp with nitrogen gas. the surface roughness, chemistry, and wettability were examined by optical profilometry, x-ray photoelectron spectroscopy, and water contact angle analysis, respective ... | 2017 | 28746053 |
| the influence of surface texture and wettability on initial bacterial adhesion on titanium and zirconium oxide dental implants. | this study aims to investigate bacterial adhesion on different titanium and ceramic implant surfaces, to correlate these findings with surface roughness and surface hydrophobicity, and to define the predominant factor for bacterial adhesion for each material. | 2017 | 28714053 |
| bacterial adherence to graft tissues in static and flow conditions. | various conduits and stent-mounted valves are used as pulmonary valve graft tissues for right ventricular outflow tract reconstruction with good hemodynamic results. valve replacement carries an increased risk of infective endocarditis (ie). recent observations have increased awareness of the risk of ie after transcatheter implantation of a stent-mounted bovine jugular vein valve. this study focused on the susceptibility of graft tissue surfaces to bacterial adherence as a potential risk factor ... | 2017 | 28712577 |
| microbiome associated with severe caries in canadian first nations children. | young indigenous children in north america suffer from a higher degree of severe early childhood caries (s-ecc) than the general population, leading to speculation that the etiology and characteristics of the disease may be distinct in this population. to address this knowledge gap, we conducted the first microbiome analysis of an indigenous population using modern molecular techniques. we investigated the caries-associated microbiome among canadian first nations children with s-ecc. thirty firs ... | 2017 | 28709393 |
| is spxa2 involved in hydrogen peroxide production and competence development in streptococcus sanguinis? | the objective of the present study was to investigate whether streptococcus sanguinis spxa2 plays a role in competence development and endogenous h2o2 generation, and whether the spxa2 cys10-xx-cys13 (cxxc) motif is involved in competence development. | 2017 | 28693663 |
| effect of arginine on the growth and biofilm formation of oral bacteria. | alkali production via arginine deiminase system (ads) of oral bacteria plays a significant role in oral ecology, ph homeostasis and inhibition of dental caries. ads activity in dental plaque varies greatly between individuals, which may profoundly affect their susceptibility to caries. | 2017 | 28668766 |
| a rare case of streptococcus sanguinis mycotic popliteal aneurysm. | mycotic popliteal aneurysms are not a common phenomenon. they can initially be easily confused with other more trivial conditions such as a baker's cyst. we present a case of a patient presenting with a progressively worsening leg swelling which was initially misdiagnosed. only until symptoms rapidly progressed was a popliteal aneurysm diagnosed. to our knowledge this is the only identified case of a streptococcus sanguinis mycotic popliteal aneurysm. | 2014 | 28663804 |
| effects of streptococcus sanguinis bacteriocin on deformation, adhesion ability, and young's modulus of candida albicans. | in order to study the thallus changes on microscopic morphology and mechanical properties of candida albicans antagonized by streptococcus sanguinis bacteriocin, the adhesion ability and young's modulus of thalli and hypha of candida albicans were measured by the relative measurement method using atomic force microscope's (afm) tapping model. the results showed that the average adhesion ability and young's modulus of thalli were 7.35 ± 0.77 nn and 7.33 ± 1.29 mpa, respectively; the average adhes ... | 2017 | 28612025 |
| distinct biological potential of streptococcus gordonii and streptococcus sanguinis revealed by comparative genome analysis. | streptococcus gordonii and streptococcus sanguinis are pioneer colonizers of dental plaque and important agents of bacterial infective endocarditis (ie). to gain a greater understanding of these two closely related species, we performed comparative analyses on 14 new s. gordonii and 5 s. sanguinis strains using various bioinformatics approaches. we revealed s. gordonii and s. sanguinis harbor open pan-genomes and share generally high sequence homology and number of core genes including virulence ... | 2017 | 28592797 |
| targeting of streptococcus mutans biofilms by a novel small molecule prevents dental caries and preserves the oral microbiome. | dental caries is a costly and prevalent disease characterized by the demineralization of the tooth's enamel. disease outcome is influenced by host factors, dietary intake, cariogenic bacteria, and other microbes. the cariogenic bacterial species streptococcus mutans metabolizes sucrose to initiate biofilm formation on the tooth surface and consequently produces lactic acid to degrade the tooth's enamel. persistence of s. mutans biofilms in the oral cavity can lead to tooth decay. to date, no ant ... | 2017 | 28571487 |
| biofilm-induced changes to the composite surface. | composites may undergo biodegradation in the oral cavity. the objective was to investigate the effect of single- and multi-species biofilms on the surface roughness and topography of two composites. | 2017 | 28554609 |
| comparative effect of photodynamic therapy on separated or mixed cultures of streptococcus mutans and streptococcus sanguinis. | antimicrobial photodynamic therapy (apdt) has shown to exert a bactericidal effect against streptococcus sanguinis and streptococcus mutans. however, this efficacy has been reported for either type of bacteria separately. bacterial suspensions of both strains, separately or together, were treated with concentrations of methylene blue (mb) and rose bengal (rb). suspensions were irradiated with a light-emitting diode lamp (λ center at 625nm for mb and λ center at 515nm for rb) using a fluence of 1 ... | 2017 | 28546111 |
| microbiomes of site-specific dental plaques from children with different caries status. | the oral microbiota associated with the initiation and progression of dental caries has yet to be fully characterized. the human oral microbe identification using next-generation sequencing (homings) approach was used to analyze the microbiomes of site-specific supragingival dental plaques from children with different caries status. fifty-five children (2 to 7 years of age) were assessed at baseline and at 12 months and grouped as caries free (cf), caries active with enamel lesions (cae), and ca ... | 2017 | 28507066 |
| air-abrasive disinfection of implant surfaces in a simulated model of periimplantitis. | this in vitro study aimed to evaluate the ability of air-powder abrasion to decontaminate dental implants. | 2017 | 28486355 |
| characterization of non-dialyzable constituents from cranberry juice that inhibit adhesion, co-aggregation and biofilm formation by oral bacteria. | an extract prepared from cranberry juice by dialysis known as nondialyzable material (ndm) has been shown previously to possess anti-adhesion activity toward microbial species including oral bacteria, uropathogenic escherichia coli and helicobacter pylori. bioassay-guided fractionation of cranberry ndm was therefore undertaken to identify the anti-adhesive constituents. an aqueous acetone-soluble fraction (ndmac) obtained from sephadex lh-20 inhibited adhesion-linked activities by oral bacteria, ... | 2017 | 28470309 |
| alternative sweeteners influence the biomass of oral biofilm. | compact-structured oral biofilm accumulates acids that upon prolonged exposure to tooth surface, causes demineralisation of enamel. this study aimed to assess the effect of alternative sweeteners equal stevia(®), tropicana slim(®), pal sweet(®) and xylitol on the matrix-forming activity of plaque biofilm at both the early and established stages of formation. | 2017 | 28448807 |
| a comparative study of oral microbiota in infants with complete cleft lip and palate or cleft soft palate. | few reports have been published on the early microbiota in infants with various types of cleft palate. we assessed the formation of the oral microbiota in infants with complete cleft lip and palate (clp n = 30) or cleft soft palate (csp n = 25) in the neonatal period (t1 time) and again in the gum pad stage (t2 time). culture swabs from the tongue, palate, and/or cleft margin at t1 and t2 were taken. we analysed the prevalence of the given bacterial species (the percentage) and the proportions i ... | 2017 | 28393073 |
| [influence of surface roughness on oral streptococcal adhesion forces to dental filling materials]. | this study is to determine the common oral streptococcal adhesion forces by using composite resin and glass ionomer cement (gic) with different degrees of surface roughness via atomic force microscopy (afm) analysis. the influence of surface roughness on bacterial adhesion force is also discussed. | 2016 | 28326699 |
| antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings. | one of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the surfaces of dental implants. modification of the surface nanotopography has been suggested to affect bacterial adherence to implants. silver nanoparticles are also known for their antibacterial properties. in this study, titanium alloy implants were surface modified following silver plating, anodisation and sintering techniques to create a combination of silver, titanium di ... | 2017 | 28281851 |
| effects of two diode lasers with and without photosensitization on contaminated implant surfaces: an ex vivo study. | the aim of this ex vivo study is to assess decontamination potential of two different diode laser wavelengths, with or without the aid of photodynamic therapy, on dental implant surfaces and to evaluate the harmful potential of temperature increase during laser irradiation. | 2017 | 28253064 |
| the evaluation of cultivable microbiota profile in patients with secondary endodontic infection before and after photo-activated disinfection. | secondary/persistent endodontic infection can be the outcome of failure of endodontic treatment. photo-activated disinfection (pad) can be a useful adjunct to mechanical and antimicrobial agents in eliminating endopathogenic microorganisms. in this study, we evaluated the effect of pad on diversity and count of microbiota related to secondary/persistent endodontic infections. | 2017 | 28249746 |
| streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide. | streptococcus is the dominant bacterial genus in the human oral cavity and a leading cause of infective endocarditis. streptococcus sanguinis belongs to the mitis group of streptococci and produces hydrogen peroxide (h2o2) by the action of spxb, a pyruvate oxidase. in this study, we investigated the involvement of spxb in survival of s. sanguinis in human blood and whether bacterial h2o2 exhibits cytotoxicity against human neutrophils. results of a bactericidal test with human whole blood reveal ... | 2017 | 28222125 |
| the miia motif is a common marker present in polytopic surface proteins of oral and urinary tract invasive bacteria. | many surface virulence factors of bacterial pathogens show mosaicism and confounding phylogenetic origin. the streptococcus gordonii platelet-binding gspb protein, the streptococcus sanguinis srpa adhesin and the streptococcus pneumoniae diia protein, share an imperfect 27-residue motif. given the disparate domain architectures of these proteins and its association to invasive disease, this motif was named miia from multiarchitecture invasion-involved motif a. miia is predicted to adopt a beta-s ... | 2017 | 28167145 |
| biofunctional polyethylene glycol coatings on titanium: an in vitro-based comparison of functionalization methods. | three methods for the production of polyethylene glycol (peg) coatings on titanium are compared, i.e. plasma polymerization, electrodeposition and silanization. the compared deposition methods presented similar wettability (hydrophilic coatings), chemical composition assessed by xps and thickness around 1nm. the coatings lowered albumin adsorption and presented a decreased fibroblast, streptococcus sanguinis and lactobacillus salivarius adhesion. immobilization of a cell adhesion peptide (rgd) p ... | 2017 | 28135680 |
| three-species biofilm model onto plasma-treated titanium implant surface. | in this study, titanium (ti) was modified with biofunctional and novel surface by micro-arc oxidation (mao) and glow discharge plasma (gdp) and we tested the development of a three-species periodontopatogenic biofilm onto the treated commercially-pure titanium (cpti) surfaces. machined and sandblasted surfaces were used as control group. several techniques for surface characterizations and monoculture on bone tissue cells were performed. a multispecies biofilm composed of streptococcus sanguinis ... | 2017 | 28131960 |
| incorporation of silver nanoparticles on the surface of orthodontic microimplants to achieve antimicrobial properties. | microbial aggregation around dental implants can lead to loss/loosening of the implants. this study was aimed at surface treating titanium microimplants with silver nanoparticles (agnps) to achieve antibacterial properties. | 2017 | 28127534 |
| effect of addition of curcumin nanoparticles on antimicrobial property and shear bond strength of orthodontic composite to bovine enamel. | this study sought to assess the effect of curcumin nanoparticles (curcnps) on antimicrobial property and shear bond strength (sbs) of orthodontic composite to bovine enamel. | 2016 | 28127332 |
| does current cefazolin dosing achieve adequate tissue and blood concentrations in obese women undergoing cesarean section? | prophylactic administration of antibiotics preceding cesarean delivery is the most effective measure taken for preventing postpartum infection. while obese women are at greater risk for infection than non-obese women, evidence-based recommendations for modifying dosing in these women are limited. | 2017 | 28122314 |
| non-thermal atmospheric pressure plasma functionalized dental implant for enhancement of bacterial resistance and osseointegration. | even though roughened titanium (ti) and ti alloys have been clinically used as dental implant, they encourage bacterial adhesion, leading to failure of the initial stability. here, the non-thermal atmospheric pressure plasma jet (ntappj) functionalized ti and ti alloy were investigated to promote cellular activities but inhibit the initial attachment of the adherent pioneer bacterium, streptococcus sanguinis, without topographical changes. | 2017 | 28088458 |
| rhamnolipids from non-pathogenic burkholderia thailandensis e264: physicochemical characterization, antimicrobial and antibiofilm efficacy against oral hygiene related pathogens. | biosurfactants are naturally occurring surface active compounds that have mainly been exploited for environmental applications and consumer products, with their biomedical efficacy an emerging area of research. rhamnolipids area major group of biosurfactants that have been reported for their antimicrobial and antibiofilm efficacy. one of the main limiting factors for scaled up production and downstream applications of rhamnolipids is the fact that they are predominantly produced from the opportu ... | 2017 | 28065676 |
| bacterial coaggregation among the most commonly isolated bacteria from contact lens cases. | to examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. | 2017 | 28061510 |
| tetr family regulator brpt modulates biofilm formation in streptococcus sanguinis. | biofilms are a key component in bacterial communities providing protection and contributing to infectious diseases. however, mechanisms involved in s. sanguinis biofilm formation have not been clearly elucidated. here, we report the identification of a novel s. sanguinis tetr repressor, brpt (biofilm regulatory protein tetr), involved in biofilm formation. deletion of brpt resulted in a significant increase in biofilm formation. interestingly, the mutant accumulated more water soluble and water ... | 2017 | 28046010 |
| streptococcus oralis neuraminidase modulates adherence to multiple carbohydrates on platelets. | adherence to host surfaces is often mediated by bacterial binding to surface carbohydrates. although it is widely appreciated that some bacterial species express glycosidases, previous studies have not considered whether bacteria bind to multiple carbohydrates within host glycans as they are modified by bacterial glycosidases. streptococcus oralis is a leading cause of subacute infective endocarditis. binding to platelets is a critical step in disease; however, the mechanisms utilized by s. oral ... | 2017 | 27993975 |
| one-pot synthesis of glutathione by a two-enzyme cascade using a thermophilic atp regeneration system. | in vitro cascade catalysis using enzyme-based system is becoming a promising biomanufacturing platform for biofuels and biochemicals production. glutathione is a pivotal non-protein thiol compound and widely applied in food and pharmaceutical industries. in this study, glutathione was synthesized by a bifunctional glutathione synthetase together with a thermophilic atp regeneration system through a two-enzyme cascade in vitro. four bifunctional glutathione synthetases from streptococcus sanguini ... | 2017 | 27919691 |
| cloning-independent markerless gene editing in streptococcus sanguinis: novel insights in type iv pilus biology. | streptococcus sanguinis, a naturally competent opportunistic human pathogen, is a gram-positive workhorse for genomics. it has recently emerged as a model for the study of type iv pili (tfp)-exceptionally widespread and important prokaryotic filaments. to enhance genetic manipulation of streptococcus sanguinis, we have developed a cloning-independent methodology, which uses a counterselectable marker and allows sophisticated markerless gene editing in situ we illustrate the utility of this metho ... | 2016 | 27903891 |
| comparative effect of a stannous fluoride toothpaste and a sodium fluoride toothpaste on a multispecies biofilm. | this paper aimed to compare the mode of action of a stannous fluoride-containing toothpaste with a conventional sodium fluoride-containing toothpaste on anti-biofilm properties. | 2017 | 27838508 |
| identification of anion channels responsible for fluoride resistance in oral streptococci. | recently, it has been reported that eric and crcb are involved in bacterial fluoride resistance. however, the fluoride-resistance mechanism in oral streptococci remains unclear. blast studies showed that two types of erics (eric1 and eric2) and two types of crcbs (crcb1 and crcb2) are present across 18 oral streptococci, which were identified in ≥ 10% of 166 orally healthy subjects with ≥ 0.01% of the mean relative abundance. they were divided into three groups based on the distribution of these ... | 2016 | 27824896 |
| evaluation of the antibacterial activity of a conventional orthodontic composite containing silver/hydroxyapatite nanoparticles. | one of the most important complications of fixed orthodontic treatment is the formation of white spots which are initial carious lesions. addition of antimicrobial agents into orthodontic adhesives might be a wise solution for prevention of white spot formation. the aim of this study was to evaluate the antibacterial properties of a conventional orthodontic adhesive containing three different concentrations of silver/hydroxyapatite nanoparticles. | 2016 | 27819127 |
| isolation and characterization of a microrna-size secretable small rna in streptococcus sanguinis. | micrornas in eukaryotic cells are thought to control highly complex signal transduction and other biological processes by regulating coding transcripts, accounting for their important role in cellular events in eukaryotes. recently, a novel class of bacterial rnas similar in size [18-22 nucleotides (nt)] to micrornas has been reported. herein, we describe micrornas, small rnas from the oral pathogen streptococcus sanguinis. the bacteria are normally present in the oral cavities and cause endocar ... | 2016 | 27796789 |
| no evidence for the growth-stimulating effect of monomers on cariogenic streptococci. | in spite of contradicting results, the high susceptibility of composites for secondary caries is still often associated with the bacterial growth-stimulating effect of released methacrylate monomers. however, most studies that showed this effect were performed with techniques having inherent limitations (spectrophotometry). | 2016 | 27766489 |
| antibacterial and anti-adherence effects of a plant extract mixture (pem) and its individual constituent extracts (psidium sp., mangifera sp., and mentha sp.) on single- and dual-species biofilms. | plant extracts mixture (pem) and its individual constituent plant extracts(psidium sp., mangifera sp., mentha sp.) are known to have an anti-adhering effect towards oral bacteria in the single-species biofilm. to date, the adhering ability of the early and late plaque colonisers (streptococcus sanguinis and streptococcus mutans) to pem-treated experimental pellicle have not been investigated in dual-species biofilms. | 2016 | 27761322 |
| efficacy of various side-to-side toothbrushes and impact of brushing parameters on noncontact biofilm removal in an interdental space model. | the objective of this study was to evaluate the efficacy of four different side-to-side toothbrushes and the impact of various brushing parameters on noncontact biofilm removal in an adjustable interdental space model. | 2016 | 27757550 |
| the impact of conical and nonconical abutments on bacterial infiltration at the implant-abutment interface. | this study evaluated the in vitro bacterial microleakage at the implant-abutment interface of three prosthetic connections: external (eh) and internal hexagon (ih) and taper connection (tc: solid [st], taper with internal hexagon [it], and short taper [ot]). escherichia coli (e coli) and streptococcus sanguinis (s sanguinus) were inoculated in the apical portion of the abutment screw, which was immersed in sterile brain-heart infusion broth for 14 days. there were no differences between the perc ... | 2016 | 27740643 |
| bacterial invasion into radicular dentine-an in vitro study. | we wanted to investigate differences in invasiveness into radicular dentinal tubules by monocultured and co-cultured bacteria frequently found in infected root canals. | 2016 | 27722787 |
| structures of the streptococcus sanguinis srpa binding region with human sialoglycans suggest features of the physiological ligand. | streptococcus sanguinis is a leading cause of bacterial infective endocarditis, a life-threatening infection of heart valves. s. sanguinis binds to human platelets with high avidity, and this adherence is likely to enhance virulence. previous studies suggest that a serine-rich repeat adhesin termed srpa mediates the binding of s. sanguinis to human platelets via its interaction with sialoglycans on the receptor gpibα. however, in vitro binding assays with srpa and defined sialoglycans failed to ... | 2016 | 27685666 |
| antimicrobial activity and regulation of cxcl9 and cxcl10 in oral keratinocytes. | chemokine (c-x-c motif) ligand (cxcl)9 and cxcl10 are dysregulated in oral inflammatory conditions, and it is not known if these chemokines target microorganisms that form oral biofilm. the aim of this study was to investigate the antimicrobial activity of cxcl9 and cxcl10 on oral microflora and their expression profiles in oral keratinocytes following exposure to inflammatory and infectious stimuli. streptococcus sanguinis was used as a model and escherichia coli as a positive control. the anti ... | 2016 | 27671889 |
| activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by streptococcus sanguinis. | streptococcus sanguinis is frequently isolated from the blood of patients with infective endocarditis and contributes to the pathology of this disease through induction of interleukin (il)-1β responsible for the development of the disease. however, the mechanism of il-1β induction remains unknown. in this study, s. sanguinis activated a murine dendritic cell (dc) to induce il-1β and this activity was attenuated by silencing the mrnas of nucleotide-binding domain-like receptor containing protein ... | 2017 | 27601185 |
| streptococcus sanguinis isolated from filler granuloma: successful treatment with incision and drainage. | filler granuloma is considered to be the result of delayed immune responses; growing evidence suggests that they may be secondary to biofilm formation. dermal filler is technically a foreign body, and as the development of newer generations of dermal fillers lengthens their duration, it is possible that there is also an increased risk of biofilm formation. here, we present a case report of a patient with streptococcus sanguinis isolated from a filler granuloma, suggestive of biofilm formation. t ... | 2016 | 27543426 |
| molecular and antimicrobial susceptibility profiling of atypical streptococcus species from porcine clinical specimens. | the streptococcus species present broad phenotypic variation, making identification difficult using only traditional microbiological methods. even though streptococcus suis is the most important species for the worldwide swine industry, other streptococcus species appear to be able to cause disease in swine and could represent a higher underestimated risk for porcine health. the aim of this study was to identify streptococcus-like isolates by maldi-tof ms and 16s rrna sequencing and further mole ... | 2016 | 27491454 |
| platelet aggregation promoted by biofilms of oral bacteria and the effect of mouth rinses in vitro. | the purpose of this study was to observe platelet aggregation promoted by biofilms of streptococcus sanguinis and porphyromonas gingivalis and to evaluate the effect of two different mouth rinses on this process. | 2016 | 27482801 |
| the road less traveled - defining molecular commensalism with streptococcus sanguinis. | the commensal oral microbial flora has evolved with the human host to support colonization of the various intraoral sites without triggering a significant immune response. in exchange, the commensal microbes provide critical protection against invading pathogens. the intrinsic ability of the oral flora to create a symbiotic microbial community with the host can be disturbed, selecting for the overgrowth of a dysbiotic community that can result in dental diseases, such as caries and periodontitis ... | 2016 | 27476770 |
| association between s. mutans and s. sanguinis in severe early childhood caries and caries-free children a quantitative real-time pcr analysis. | to identify s. mutans and s. sanguinis in initial and overnight plaque between 2 groups and to analyze the association between them and caries-related factors. | 2016 | 27471805 |
| staphylococcus aureus srrab affects susceptibility to hydrogen peroxide and co-existence with streptococcus sanguinis. | staphylococcus aureus is a pathogen and a commensal bacterial species that is found in humans. bacterial two-component systems (tcss) sense and respond to environmental stresses, which include antimicrobial agents produced by other bacteria. in this study, we analyzed the relation between the tcs srrab and susceptibility to the hydrogen peroxide (h2o2) that is produced by streptococcus sanguinis, which is a commensal oral streptococcus. an srra-inactivated s. aureus mutant demonstrated low susce ... | 2016 | 27441894 |
| interactions between lactobacillus rhamnosus gg and oral micro-organisms in an in vitro biofilm model. | probiotics have shown favourable properties in maintaining oral health. by interacting with oral microbial communities, these species could contribute to healthier microbial equilibrium. this study aimed to investigate in vitro the ability of probiotic lactobacillus rhamnosus gg (l.gg) to integrate in oral biofilm and affect its species composition. five oral strains, streptococcus mutans, streptococcus sanguinis, aggregatibacter actinomycetemcomitans, fusobacterium nucleatum and candida albican ... | 2016 | 27405227 |
| impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria. | peri-implantitis, an inflammation caused by biofilm formation, constitutes a major cause of implant failure in dentistry. thus, the detection of bacteria at the early steps of biofilm growth represents a powerful strategy to prevent implant-related infections. in this regard, antimicrobial peptides (amps) can be used as effective biological recognition elements to selectively detect the presence of bacteria. thus, the aim of the present study was to combine the use of miniaturized and integrated ... | 2016 | 27399935 |
| hydroxychalcone inhibitors of streptococcus mutans glucosyl transferases and biofilms as potential anticaries agents. | streptococcus mutans has been implicated as the major etiological agent in the initiation and the development of dental caries due to its robust capacity to form tenacious biofilms. ideal therapeutics for this disease will aim to selectively inhibit the biofilm formation process while preserving the natural bacterial flora of the mouth. several studies have demonstrated the efficacies of flavonols on s. mutans biofilms and have suggested the mechanism of action through their effect on s. mutans ... | 2016 | 27371109 |
| effect of antimicrobial denture base resin on multi-species biofilm formation. | our aims of the research were to study the antimicrobial effect of dimethylaminododecyl methacrylate (dmaddm) modified denture base resin on multi-species biofilms and the biocompatibility of this modified dental material. candida albicans (c. albicans), streptococcus mutans (s. mutans), streptococcus sanguinis (s. sanguinis), as well as actinomyces naeslundii (a. naeslundii) were used for biofilm formation on denture base resin. colony forming unit (cfu) counts, microbial viability staining, an ... | 2016 | 27367683 |
| pleurocidin congeners demonstrate activity against streptococcus and low toxicity on gingival fibroblasts. | fish epidermal antimicrobial peptides, such as pleurocidin, are cathelicidins with broad-spectrum antimicrobial activity against gram negative and gram-positive bacteria, as well as fungi. in the current study, we attempted to optimize peptide bioactivity by sequence modification and assess the antimicrobial activities. | 2016 | 27341459 |
| differential utilization of basic proline-rich glycoproteins during growth of oral bacteria in saliva. | although saliva is widely recognized as a primary source of carbon and nitrogen for growth of the dental plaque biofilm community, little is known about how different oral bacteria utilize specific salivary components. to address this question, 32 strains representing 16 genera commonly isolated from early plaque biofilms were compared for growth over two transfers in stimulated (by chewing parafilm) whole saliva that was stabilized by heat treatment and dialysis. the cell densities, measured by ... | 2016 | 27316966 |
| apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. | infective endocarditis is caused by streptococcus sanguinis present in dental plaque, which can induce inflammatory responses in the endocardium. the present study depicts research on the properties of apigenin in embryonic mouse heart cells (h9c2) treated with lipoteichoic acid (lta) obtained from s. sanguinis. interleukin-1β and cyclooxygenase (cox)-2 expression were detected by reverse transcriptase polymerase chain reaction. in addition, western blot assays and immuno-fluorescence staining w ... | 2017 | 27193174 |
| lack of buffering by composites promotes shift to more cariogenic bacteria. | secondary caries (sc) remains a very important problem with composite restorations. the objectives of this study were to test the acid-buffering ability of several restorative materials and to evaluate whether buffering of the restorative material has an impact on the microbial composition of the biofilm. disk-shaped specimens of conventional composite, composite with surface prereacted glass-ionomer filler particles (so-called giomer), glass-ionomer cement (gic), amalgam, and hydroxyapatite (ha ... | 2016 | 27146702 |
| probing the nanoadhesion of streptococcus sanguinis to titanium implant surfaces by atomic force microscopy. | as titanium (ti) continues to be utilized in great extent for the fabrication of artificial implants, it is important to understand the crucial bacterium-ti interaction occurring during the initial phases of biofilm formation. by employing a single-cell force spectroscopy technique, the nanoadhesive interactions between the early-colonizing streptococcus sanguinis and a clinically analogous smooth ti substrate were explored. mean adhesion forces between s. sanguinis and ti were found to be 0.32± ... | 2016 | 27103802 |
| a massive haemothorax as an unusual complication of infective endocarditis caused by streptococcus sanguinis. | infective endocarditis involving the tricuspid valve is an uncommon condition, and a consequent haemothorax associated with pulmonary embolism is extremely rare. particularly, there are no guidelines for the management of this complication. we describe a rare case of pulmonary embolism and infarction followed by a haemothorax due to infective endocarditis of the tricuspid valve caused by streptococcus sanguinis. | 2016 | 27075785 |
| novel aspects of sialoglycan recognition by the siglec-like domains of streptococcal srr glycoproteins. | serine-rich repeat glycoproteins are adhesins expressed by commensal and pathogenic gram-positive bacteria. a subset of these adhesins, expressed by oral streptococci, binds sialylated glycans decorating human salivary mucin mg2/muc7, and platelet glycoprotein gpib. specific sialoglycan targets were previously identified for the ligand-binding regions (brs) of gspb and hsa, two serine-rich repeat glycoproteins expressed by streptococcus gordonii while gspb selectively binds sialyl-t antigen, hsa ... | 2016 | 27037304 |
| comparison of bacterial adhesion to dental materials of polyethylene terephthalate (pet) and polymethyl methacrylate (pmma) using atomic force microscopy and scanning electron microscopy. | the aim of this study was to compare the bacterial adhesion to denture materials of polyethylene terephthalate (pet) and polymethyl methacrylate (pmma) using atomic force microscopy and scanning electron microscopy. the adhesion forces of living streptococcus sanguinis and streptococcus mutans to pet and pmma were directly measured using atomic force microscopy (afm) in liquid. streptococcal biofilms formed on the two material surfaces were investigated and compared using scanning electron micro ... | 2016 | 26991988 |
| involvement of nadh oxidase in biofilm formation in streptococcus sanguinis. | biofilms play important roles in microbial communities and are related to infectious diseases. here, we report direct evidence that a bacterial nox gene encoding nadh oxidase is involved in biofilm formation. a dramatic reduction in biofilm formation was observed in a streptococcus sanguinis nox mutant under anaerobic conditions without any decrease in growth. the membrane fluidity of the mutant bacterial cells was found to be decreased and the fatty acid composition altered, with increased palm ... | 2016 | 26950587 |
| in silico dissection of type vii secretion system components across bacteria: new directions towards functional characterization. | type vii secretion system (t7ss) is one of the factors involved in virulence of mycobacterium tuberculosis h37rv. numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. an extensive genome-wide analysis through compilation of isolated information is required to obtain a global view of diverse characteristics and pathogenicity-related aspects of this machinery. the present study suggests that differences in structural components ... | 2016 | 26949095 |
| involvement of nadh oxidase in competition and endocarditis virulence in streptococcus sanguinis. | here, we report for the first time that the streptococcus sanguinis nox gene encoding nadh oxidase is involved in both competition with streptococcus mutans and virulence for infective endocarditis. an s. sanguinis nox mutant was found to fail to inhibit the growth of streptococcus mutans under microaerobic conditions. in the presence of oxygen, the recombinant nox protein of s. sanguinis could reduce oxygen to water and oxidize nadh to nad(+) the oxidation of nadh to nad(+) was diminished in th ... | 2016 | 26930704 |
| effect of roselle calyx extract on in vitro viability and biofilm formation ability of oral pathogenic bacteria. | to investigate the effect of the roselle calyx extract (rce) (hibiscus sabdariffa l.) on the in vitro viability and biofilm formation ability of oral pathogenic bacteria. | 2016 | 26919939 |
| effects of repeated screw tightening on implant abutment interfaces in terms of bacterial and yeast leakage in vitro: one-time abutment versus the multiscrewing technique. | screw loosening can damage the interfaces of implant components, resulting in susceptibility to contamination of the internal parts by microorganisms. the aim of this study was to investigate the impact of abutment screw retightening on the leakage of two different types of bacteria, streptococcus sanguinis and fusobacterium nucleatum, and of the yeast candida albicans. two types of implant-abutment systems with tube-in-tube interfaces were tested. groups a and b each used a different type of sy ... | 2016 | 26901305 |
| antibacterial effect of hydroalcoholic extract of punica granatum linn. petal on common oral microorganisms. | objectives. this study aimed to assess the effect of hydroalcoholic extract of punica granatum linn. (p. granatum) petal on streptococcus sanguinis, streptococcus mutans, streptococcus salivarius, streptococcus sobrinus, and enterococcus faecalis. materials and methods. in this in vitro study, p. granatum extract was prepared using powdered petals and water-ethanol solvent. antibacterial effect of the extract, chlorhexidine (chx), and ampicillin was evaluated on brain heart infusion agar (bhia) ... | 2016 | 26884763 |
| spxb-mediated h2 o2 induces programmed cell death in streptococcus sanguinis. | streptococcus sanguinis (s. sanguinis) is a commensal oral streptococci that produces hydrogen peroxide (h2 o2 ), and this production is dependent on pyruvate oxidase (spxb) activity. in addition to its well-known role in intraspecies or interspecies competitions, recent studies have shown that h2 o2 produced by s. sanguinis under aerobic conditions not only upregulates biofilm formation and edna release but also regulates cell death without obvious cell lysis. here, we report that s. sanguinis ... | 2016 | 26879582 |
| antimicrobial effects of commensal oral species are regulated by environmental factors. | the objectives of this study are to identify oral commensal species which can inhibit the growth of the main periodontopathogens, to determine the antimicrobial substances involved in these inhibitory activities and to evaluate the influence of environmental factors on the magnitude of these inhibitions. | 2016 | 26875613 |
| structural basis for sialoglycan binding by the streptococcus sanguinis srpa adhesin. | streptococcus sanguinisis a leading cause of infective endocarditis, a life-threatening infection of the cardiovascular system. an important interaction in the pathogenesis of infective endocarditis is attachment of the organisms to host platelets.s. sanguinisexpresses a serine-rich repeat adhesin, srpa, similar in sequence to platelet-binding adhesins associated with increased virulence in this disease. in this study, we determined the first crystal structure of the putative binding region of s ... | 2016 | 26833566 |
| a highly arginolytic streptococcus species that potently antagonizes streptococcus mutans. | the ability of certain oral biofilm bacteria to moderate ph through arginine metabolism by the arginine deiminase system (ads) is a deterrent to the development of dental caries. here, we characterize a novel streptococcus strain, designated strain a12, isolated from supragingival dental plaque of a caries-free individual. a12 not only expressed the ads pathway at high levels under a variety of conditions but also effectively inhibited growth and two intercellular signaling pathways of the denta ... | 2016 | 26826230 |
| reduced glutathione mediates resistance to h2s toxicity in oral streptococci. | periodontal disease is associated with changes in the composition of the oral microflora, where health-associated oral streptococci decrease while gram-negative anaerobes predominate in disease. a key feature of periodontal disease-associated anaerobes is their ability to produce hydrogen sulfide (h2s) abundantly as a by-product of anaerobic metabolism. so far, h2s has been reported to be either cytoprotective or cytotoxic by modulating bacterial antioxidant defense systems. although oral anaero ... | 2016 | 26801579 |
| modulation of candida albicans virulence by bacterial biofilms on titanium surfaces. | whilst candida albicans occurs in peri-implant biofilms, its role in peri-implantitis remains unclear. this study therefore examined the virulence of c. albicans in mixed-species biofilms on titanium surfaces. biofilms of c. albicans (ca), c. albicans with streptococci (streptococcus sanguinis, s. mutans) (ca-ss-sm) and those incorporating porphyromonas gingivalis (ca-pg and ca-ss-sm-pg) were developed. expression of c. albicans genes associated with adhesion (als1, als3, hwp1) and hydrolytic en ... | 2016 | 26795585 |
| ceftaroline activity tested against viridans group streptococci from us hospitals. | a total of 840 clinically relevant viridans group streptococci (vgs) isolates (1/patient episode) were collected from 71 us medical centers in 2013-2014. these organisms were tested for susceptibility by reference broth microdilution methods against ceftaroline and selected comparator agents. all isolates were speciated by matrix-assisted laser desorption ionization-time-of-flight (maldi-tof) mass spectrometry and were primarily from skin/soft tissue (32.6%) and bloodstream (32.3%) infections. c ... | 2016 | 26658313 |
| effect of enamel morphology on nanoscale adhesion forces of streptococcal bacteria : an afm study. | we explore the influence of enamel surface morphology on nanoscale bacterial adhesion forces. three dimensional morphology characteristics of enamel slices, which were treated with phosphoric acid (for 0 s, 5 s, 10 s, 20 s, and 30 s), were acquired. adhesion forces of three initial colonizers (streptococcus oralis, streptococcus sanguinis, and streptococcus mitis) and two cariogenic bacterial strains (streptococcus mutans and streptococcus sobrinus) with etched enamel surfaces were determined. c ... | 2015 | 26482011 |
| adherence of oral streptococci to nanostructured titanium surfaces. | peri-implantitis and peri-mucositis pose a severe threat to the success of dental implants. current research focuses on the development of surfaces that inhibit biofilm formation while not inferring with tissue integration. this study compared the adherence of two oral bacterial species, streptococcus sanguinis and streptococcus mutans to nanostructured titanium surfaces. | 2015 | 26467718 |
| can pulp fibroblasts kill cariogenic bacteria? role of complement activation. | complement system activation has been shown to be involved in inflammation and regeneration processes that can be observed within the dental pulp after moderate carious decay. studies simulating carious injuries in vitro have shown that when human pulp fibroblasts are stimulated by lipoteichoic acid (lta), they synthetize all complement components. complement activation leads to the formation of the membrane attack complex (mac), which is known for its bacterial lytic effect. this work was desig ... | 2015 | 26464397 |
| functional analysis of an unusual type iv pilus in the gram-positive streptococcus sanguinis. | type iv pili (tfp), which have been studied extensively in a few gram-negative species, are the paradigm of a group of widespread and functionally versatile nano-machines. here, we performed the most detailed molecular characterisation of tfp in a gram-positive bacterium. we demonstrate that the naturally competent streptococcus sanguinis produces retractable tfp, which like their gram-negative counterparts can generate hundreds of piconewton of tensile force and promote intense surface-associat ... | 2015 | 26435398 |
| behçet's disease heterogeneity: cytokine production and oxidative burst of phagocytes are altered in patients with severe manifestations. | to test the hypothesis that classical phagocytic functions are constitutively stimulated in patients with behçet's disease (bd). | 2017 | 26394190 |
| in vitro effect of zingiber officinale extract on growth of streptococcus mutans and streptococcus sanguinis. | background and objectives. tooth decay is an infectious disease of microbial origin. considering the increasing prevalence of antibiotic resistance due to their overuse and also their side effects, medicinal plants are now considered for use against bacterial infections. this study aimed to assess the effects of different concentrations of zingiber officinale extract on proliferation of streptococcus mutans and streptococcus sanguinis in vitro. materials and methods. in this experimental study, ... | 2015 | 26347778 |
| interference of antimicrobial activity of combinations of oral antiseptics against streptococcus mutans, streptococcus sanguinis, and lactobacillus acidophilus. | the purpose of this study was to compare the effects of combinations of sodium fluoride and antiseptic compounds on the growth of streptococcus mutans, streptococcus sanguinis, and lactobacillus acidophilus. | 2017 | 26314599 |
| oral streptococci biofilm formation on different implant surface topographies. | the establishment of the subgingival microbiota is dependent on successive colonization of the implant surface by bacterial species. different implant surface topographies could influence the bacterial adsorption and therefore jeopardize the implant survival. this study evaluated the biofilm formation capacity of five oral streptococci species on two titanium surface topographies. in vitro biofilm formation was induced on 30 titanium discs divided in two groups: sandblasted acid-etched (sae- n = ... | 2015 | 26273590 |
| the role of nicotine, cotinine and caffeine on the electrochemical behavior and bacterial colonization to cp-ti. | although smoking promotes deleterious effect to bone healing, there is a lack of study investigating its role on the implant structure and biofilm growth. we hypothesized that nicotine, cotinine and caffeine would impair the corrosion resistance of commercially-pure titanium (cp-ti) and would enhance streptococcus sanguinis biofilm growth. neither the smoking products nor the caffeine affected the corrosion tendency (p>.05) and the oxide layer resistance (p=.762) of cp-ti. lower capacitance valu ... | 2015 | 26249572 |
| antagonistic effect of peptidoglycan of streptococcus sanguinis on lipopolysaccharide of major periodontal pathogens. | streptococcus sanguinis is often found in subgingival biofilm including periodontopathogens, and is correlated with a delay in colonization by periodontopathogens. however, the effect of s. sanguinis on inflammation induced by periodontopathogens is poorly understood. thus, this study investigated the effect of s. sanguinis peptidoglycan (pgn) on induction of tnf-α, il-6, and il-8 expression by lipopolysaccharide (lps) of periodontal pathogens. lps was extracted from aggregatibacter actinomycete ... | 2015 | 26224458 |
| selective propensity of bovine jugular vein material to bacterial adhesions: an in-vitro study. | percutaneous pulmonary valve implantation (ppvi) using melody valve made of bovine jugular vein is safe and effective. however, infective endocarditis has been reported for unclear reasons. we sought to assess the impact of valvular substrates on selective bacterial adhesion. | 2015 | 26173058 |
| absence of capsule reveals glycan-mediated binding and recognition of salivary mucin muc7 by streptococcus pneumoniae. | salivary proteins modulate bacterial colonization in the oral cavity and interact with systemic pathogens that pass through the oropharynx. an interesting example is the opportunistic respiratory pathogen streptococcus pneumoniae that normally resides in the nasopharynx, but belongs to the greater mitis group of streptococci, most of which colonize the oral cavity. streptococcus pneumoniae also expresses a serine-rich repeat (srr) adhesin, psrp, which is a homologue to oral mitis group srr adhes ... | 2016 | 26172471 |
| effect of punica granatum l. flower water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire. | use of herbal extracts and essences as natural antibacterial compounds has become increasingly popular for the control of oral infectious diseases. therefore, finding natural antimicrobial products with the lowest side effects seems necessary. the present study sought to assess the effect of punica granatum l. water extract on five oral bacteria and bacterial biofilm formation on orthodontic wire. | 2014 | 26171362 |
| antimicrobial activity of the essential oil of plectranthus neochilus against cariogenic bacteria. | this work used the broth microdilution method to investigate the antimicrobial activity of the essential oil obtained from the leaves of plectranthus neochilus (pn-eo) against a representative panel of oral pathogens. we assessed the antimicrobial activity of this oil in terms of the minimum inhibitory concentration (mic). pn-eo displayed moderate activity against enterococcus faecalis (mic = 250 μg/ml) and streptococcus salivarus (mic = 250 μg/ml), significant activity against streptococcus sob ... | 2015 | 26161115 |