Publications

viral load, e2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia.	the clinical utility of human papillomavirus (hpv) load and integration status remains unclear. we applied refined methods to delineate the viral load, integration status, and lineage of 104 women with hpv-16 monotype infection, including 19 with normal cervices, 9 with histologically proven cervical intraepithelial neoplasia (cin) 1, 24 with cin 2, 27 with cin 3, and 25 with squamous cell carcinoma (scc). higher crude viral load, as determined by real-time polymerase chain reaction (pcr) target ...	2006	17109343
human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern china.	a case-control study was conducted on 1986 hong kong women to assess the risk of human papillomavirus (hpv) type 16 variants for cervical neoplasia. in total, 255 women were hpv-16 positive and were analyzed for e6 and e7 sequence variation. two novel substitutions at e6 (t86i and q116e) and 1 at e7 (r66w) were found. most hpv-16 variants were of asian (50.6%) or european (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. no increa ...	2002	12195358
presence of human papillomavirus in esophageal squamous cell carcinomas of hong kong chinese and its relationship with p53 gene mutation.	there is no scientific study that has investigated the association between human papilloma virus (hpv) and p53 mutation in hong kong chinese patients with esophageal cancers. the aim of this survey is to evaluate in details the prevalence and relationship of hpv and p53 mutation in these patients with esophageal squamous cell carcinomas. fresh tissues from the resected specimens of 70 chinese patients (59 men, 11 women) with primary esophageal squamous cell carcinomas (20 well-differentiated, 36 ...	1997	9190999
the physical state of human papillomavirus type 16 dna in cervical carcinomas of hong kong chinese.	the presence of human papillomavirus (hpv) in 15 cervical carcinoma specimens obtained from hong kong chinese patients was analyzed by southern blot hybridization studies. in nine (60%) of them, hpv 16 genomes were detected, while two others (13.3%) were found to harbor hpv dna of unknown type closely related to hpv 16. all of them were classified as squamous cell carcinomas according to who guidelines. in addition, the presence of hpv 18 was shown in another two (13.3%) squamous cell carcinoma ...	1991	1653409