Publications

the principal genetic determinants for nasopharyngeal carcinoma in china involve the hla class i antigen recognition groove.	nasopharyngeal carcinoma (npc) is an epithelial malignancy facilitated by epstein-barr virus infection. here we resolve the major genetic influences for npc incidence using a genome-wide association study (gwas), independent cohort replication, and high-resolution molecular hla class i gene typing including 4,055 study participants from the guangxi zhuang autonomous region and guangdong province of southern china. we detect and replicate strong association signals involving snps, hla alleles, an ...	2012	23209447
evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of southern china.	to understand the role of environmental and genetic influences on nasopharyngeal carcinoma (npc) in populations at high risk of npc, we have performed a case-control study in guangxi province of southern china in 2004-2005. npc cases (n = 1,049) were compared with 785 npc-free matched controls who were seropositive for iga antibodies (iga) to epstein-barr virus (ebv) capsid antigen (vca)-a predictive marker for npc in chinese populations. a questionnaire was used to capture exposure and npc fami ...	2009	19296536
comparison of epstein-barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between guilin, china and fukuoka, japan.	epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc) is endemic to guilin, china, but not fukuoka, japan. to examine whether the npc in these two cities are distinct in their association with ebv, we analyzed the histology and ebv genotypes in 163 npc from guilin, 52 npc from fukuoka and non-cancerous control nasopharyngeal tissues (n=22 each) by in situ hybridization and pcr. the proportion of ebv-positive npc from guilin (95%) was higher than that of fukuoka (55%, p<0.001), and h ...	2008	18497945
genetic factors leading to chronic epstein-barr virus infection and nasopharyngeal carcinoma in south east china: study design, methods and feasibility.	nasopharyngeal carcinoma (npc) is a complex disease caused by a combination of epstein-barr virus chronic infection, the environment and host genes in a multi-step process of carcinogenesis. the identity of genetic factors involved in the development of chronic epstein-barr virus infection and npc remains elusive, however. here, we describe a two-phase, population-based, case-control study of han chinese from guangxi province, where the npc incidence rate rises to a high of 25-50 per 100,000 ind ...	2006	16848974
[association study of chromosome 4 strs polymorphisms with nasopharyngeal carcinoma].	nasopharyngeal carcinoma (npc) is a complex disease caused by an interaction of ebv chronic infection, environment and host genes, in a multi-step process of carcinogenesis. however, which genetic factors play an important role in the development of chronic ebv infection and npc remain elusive. the objective of this study is to identify genetic variations associated with two key clinical stages of npc development: persistent epstein-barr virus (ebv) infection of nasopharyngeal epithelia and prog ...	2006	16825163
[serologic screening on nasopharyngeal cancer in 338,868 persons in 21 cities and counties of guangxi region, china].	serological screening on nasopharyngeal cancer in 338,868 persons living in 21 cities and counties of guangxi zhuang autonomous region was carried out from january 1991 to september 1993. results showed 9367 persons were positive for iga antibodies to epstein-barr virus (ebv) capsid antigen, and 306 of them positive for iga to ebv early antigen. one hundred and thirteen cases of nasopharyngeal cancer were detected in the former with 100 cases (88.5%) in the early stage, and 63 cases in the latte ...	1995	8697937
serological survey of nasopharyngeal carcinoma in 21 cities of south china.	this paper reports the results of serological survey of 318,912 persons for nasopharyngeal carcinoma (npc) in 21 cities and counties of south china. there were 8,441 persons with positive vca-iga antibody (single item positive) of eb virus (ebv), with a rate of 2.65%. in these vca-iga positive persons, 287 persons also had positive ea-iga (double items positive) of ebv. the overall positive rate was 0.09%. 100 cases of npc were found and 87 of them (87.0%) were in early stage. npc found in the g ...	1995	7789220
mutations clustered in exon 5 of the p53 gene in primary nasopharyngeal carcinomas from southeastern asia.	mutations in the p53 tumor suppressor gene play an important role in the development of many common human malignancies. in nasopharyngeal carcinomas (npc), p53 gene mutations were not detected in primary tumors, with one exception for a primary tumor displaying a p53 mutation at codon 280, whereas p53 mutations were identified in some metastatic and nude mouse-passaged npc specimens. in the present report, 41 npc primary tumors of the undifferentiated carcinoma nasopharyngeal type (ucnt; 21 from ...	1995	7729941
the chinese epidemiological approach of nasopharyngeal carcinoma research and control.	nasopharyngeal carcinoma (npc), the major cancer killer in cantonese chinese, represents one of the three cancer research priorities in china. apart from some fundamental research projects on the epstein-barr virus (ebv), their main efforts are epidemiologically and clinically oriented. major surveys in guangdong and guangxi provinces showed that high ebv/iga/vca serum levels can detect npc at an early stage of the disease. characterization of "precancerous lesions" in the nasopharynx and among ...	1981	6264696
prospective studies on nasopharyngeal carcinoma in epstein-barr virus iga/vca antibody-positive persons in wuzhou city, china.	a serological mass survey was carried out in wuzhou city in 1980, 1,136 iga/vca-positive persons being followed up for 4 years. altogether 35 npc cases were detected, of which 15 (43%) were in stage i and 17 (48.5%) in stage ii, early cases (i + ii) thus amounting to 91.5%. the detection rate of early cases was 2.9 times higher than in our outpatient clinic. iga/vca antibody could be detected 16-41 months prior to clinical diagnosis of npc. we conclude that, if iga/vca-positive individuals are e ...	1985	4055129
epstein-barr virus seroepidemiology in china.	since 1978 more than 300,000 sera from normal individuals were screened serologically in npc high risk areas and prospective studies were carried out. many patients were diagnosed in early stage. for example, in wuzhou city, 20,726 persons over 40 years of age were screened; 1,138 persons were found to have iga vca antibody. among them 18 npc cases were detected; an additional 21 npc patients were found within 5 year follow-up studies. altogether there were 39 npc patients. as compared to the pa ...	1986	3030349