Publications

TitleAbstractYear
Filter
PMID(sorted descending)
Filter
proportions of mycobacterium massiliense and mycobacterium bolletii strains among korean mycobacterium chelonae-mycobacterium abscessus group isolates.korean isolates of the mycobacterium chelonae-mycobacterium abscessus group, which had been isolated from two different hospitals in south korea, were identified by pcr restriction analysis (pra) and comparative sequence analysis of 16s rrna genes, rpob, and hsp65 to evaluate the proportion of four closely related species (m. chelonae, m. abscessus, m. massiliense, and m. bolletii). of the 144 rapidly growing mycobacterial strains tested, 127 strains (88.2%) belonged to the m. chelonae-m. absces ...200818753344
postoperative mycobacterium abscessus nodular conjunctivitis.non-tuberculous or 'atypical' mycobacteria are unusual causes of ocular or periocular infection. we report a case of postoperative mycobacterium abscessus infection of the conjunctiva. a 71-year-old gentleman developed nodular conjunctival injection and irritation 6 weeks after cataract surgery. after failure of topical therapy with antibiotics, steroids and lubricants, a biopsy was taken. histological examination revealed non-caseating granulomas within which were clusters of acid-fast bacilli, ...200818700926
mycobacterium abscessus infection secondary to mesotherapy. 200818616719
in vitro activity of flomoxef against rapidly growing mycobacteria.the aim of this study was to determine the in vitro sensitivity of rapidly growing mycobacteria (rgm) to flomoxef in respiratory secretions collected from 61 consecutive inpatients and outpatients at chang gung memorial hospital-kaohsiung medical center between july and december, 2005. minimal inhibitory concentrations (mic) of flomoxef were determined by the broth dilution method for the 61 clinical isolates of rgms. the mics of flomoxef at which 90% of clinical isolates were inhibited was >128 ...200818606583
association between microsatellite polymorphisms in intron ii of the human toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a korean population.this study evaluated the association between the guanine-thymine (gt) repeat polymorphism in intron ii of the toll-like receptor 2 (tlr2) gene and lung disease caused by nontuberculous mycobacteria (ntm). polymerase chain reaction and gene scans were used to determine the numbers of gt repeats for 193 patients with the nodular bronchiectatic form of ntm lung disease, including 110 patients with mycobacterium avium-intracellulare (mac) infection, 82 patients with mycobacterium abscessus infection ...200818602432
an autopsy case of mycobacterium abscessus pulmonary infection complicated with rheumatoid arthritis.we present the case of a 70-year-old man diagnosed with mycobacterium abscessus pulmonary infection complicated with rheumatoid arthritis who was treated with corticosteroids. he died despite treatment according to the recommended regimen of imipenem, clarithromycin, and amikacin. autopsy revealed granulomatous lesions throughout the bilateral lungs. we conclude that m. abscessus infection may have a fatal outcome because of the drug resistance of the pathogen. this case suggests that rheumatoid ...200818591855
rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in mycobacterium tuberculosis complex.to design and standardize an in-house reverse line blot hybridization (rlbh) assay for the accurate identification of 15 clinically relevant species of mycobacteria and for the detection of drug resistance to rifampin (rif), isoniazid (inh), and streptomycin (str) in mycobacterium tuberculosis complex (mtb).200918565777
late-onset posttraumatic skin and soft-tissue infections caused by rapid-growing mycobacteria in tsunami survivors.in the tsunami catastrophe in thailand in 2004, several thousand swedish tourists were injured, with contaminated crush trauma of the legs being the main cause of injury among the survivors.200818549312
spectrum of cns disease caused by rapidly growing mycobacteria.we present a case of a patient with chronic meningoencephalitis caused by mycobacterium abscessus. we also summarise the clinical features and outcomes of cases of cns infection caused by rapidly growing mycobacteria that have been described in the literature. rapidly growing mycobacteria are notorious for causing skin and soft-tissue infections after trauma or surgery, pulmonary disease in patients with cystic fibrosis, and disseminated disease in immunocompromised patients. cns infection with ...200818501854
interleukin-12 receptor beta1 polymorphisms and nontuberculous mycobacterial lung diseases.the pathway involving interferon-gamma and interleukin (il)-12 plays an important role in host defense against mycobacterial infections. recent studies have indicated that il-12 receptor beta1 (il-12rbeta1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. however, there have been no reports of an association between il-12rbeta1 gene polymorphism and lung disease caused by nontuberculous mycobacteria (ntm). the present study involved 128 patients with the nodular b ...200818493823
mycobacterium abscessus infection after breast augmentation: a case of contaminated implants?infections after breast augmentation are uncommon, occurring in 1-3% of cases. treatment often requires additional surgeries and may yield a sub-optimal cosmetic result. for this reason, post implant infection remains a serious concern among plastic surgeons. a 48-year-old female presented to our clinic with bilateral breast implant infections 3 months after primary augmentation in china. cultures grew mycobacterium abscessus, a previously undescribed infectious aetiology after breast augmentati ...200918485852
disseminated cutaneous infection with mycobacterium abscessus in a patient with a low cd4+ t cell count.we report an uncommon case of disseminated cutaneous infection with mycobacterium abscessus. the patient was a 22-year-old female with low level of cd4+ t cells in the peripheral blood cells, who presented with a number of tender red nodules, erythema and erythematous infiltrated plaques on her cheek, neck and extremities. colonies without pigment grew after incubating on löwenstein-jensen (l-j) medium at 37 degrees c and 32 degrees c for 3-5 days. polymerase chain reaction (pcr) amplification o ...200818474467
mycobacterium abscessus infection complicating hand rejuvenation with structural fat grafting.summary: we report a case of mycobacterium abscessus infection of the hands in a 55 year old lady following hand rejuvenation with structural fat grafting. a review of the literature on m. abscessus infection to discuss common presentations, diagnosis and treatment is presented. awareness and high suspicion of such as atypical mycobacterial infections complicating hand surgery and other plastic surgery procedures is imperative to successful management.200918472321
antimicrobial resistance of rapidly growing mycobacteria in western taiwan: smart program 2002.to understand the resistance patterns of rapidly growing mycobacteria (rgm) in taiwan, antimicrobial resistance of clinical isolates was determined as part of the smart (surveillance from multicenter antimicrobial resistance in taiwan) program.200818445541
outbreak of mycobacterium abscessus wound infections among "lipotourists" from the united states who underwent abdominoplasty in the dominican republic.some us residents travel abroad to undergo cosmetic surgery for fat removal, a practice referred to as "lipotourism." mycobacterium abscessus can cause postsurgical wound infection.200818444853
mycobacterium abscessus and m. avium trigger toll-like receptor 2 and distinct cytokine response in human cells.mycobacterium avium (mav) and m. abscessus (mab) are ubiquitous environmental organisms increasingly recognized to cause chronic lung disease in patients with apparently normal immune function. little is yet known about their human pathophysiology. our objective was to examine cytokine and chemokine responses (protein and gene expression) and signaling pathways triggered by reference and clinical isolates of mab and mav in human peripheral blood mononuclear cells, monocytes, and murine bone marr ...200818441280
differential antibiotic susceptibility of mycobacterium abscessus variants in biofilms and macrophages compared to that of planktonic bacteria.mycobacterium abscessus causes refractory pulmonary infections requiring surgery for cure. it exists as a smooth biofilm-forming phenotype which is noninvasive and a rough, non-biofilm-forming phenotype which can invade macrophages and cause persistent pulmonary infection in mice. we have postulated that the dissociation of the smooth phenotype to the rough phenotype may lead to invasive lung disease following initial colonization of the airways. amikacin, cefoxitin, and clarithromycin are stand ...200818378709
mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between tlr2 and dectin-1.mycobacterium abscessus (mab) is an emerging and rapidly growing non-tuberculous mycobacterium (ntm). compared with m. tuberculosis, which is responsible for tuberculosis, much less is known about ntm-induced innate immune mechanisms. here we investigated the involvement of pattern-recognition receptors and associated signalling in mab-mediated innate immune responses. mab activated the extracellular signal-regulated kinase (erk)1/2 and p38 mitogen-activated protein kinases (mapks), and induced ...200818373632
in vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against mycobacterium tuberculosis and non-tuberculous mycobacteria.sulfometuron methyl (sm) is an inhibitor of acetohydroxyacid synthase (ahas), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against mycobacterium tuberculosis both in vitro and in vivo. to develop ahas inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against m. tuberculosis and non-tuberculous mycobacteria (ntm), and then evaluated for intracellular activity using mouse mac ...200818337064
animal model of mycobacterium abscessus lung infection.chronic lung disease as a result of mycobacterium abscessus is an emerging infection in the united states. we characterized the lung immune responses in mice and guinea pigs infected with m. abscessus. c57bl/6 and leptin-deficient ob/ob mice challenged with a low-dose aerosol (lda) of m. abscessus did not develop an infection. however, when challenged with a high-dose aerosol (hda), c57bl/6 and ob/ob mice developed an established infection and a pulmonary immune response consisting of an early i ...200818310351
in vitro antimicrobial susceptibility of mycobacterium abscessus in korea.mycobacterium abscessus is the second most common etiology of pulmonary disease caused by nontuberculous mycobacteria in korea. although antimicrobial susceptibility tests are important for appropriate patient management in m. abscessus lung disease, the tests have never been investigated in korea. seventy-four isolates of m. abscessus recovered from patient respiratory samples were tested against eight antimicrobial agents following the guidelines set forth by the national committee for clinica ...200818303198
the organization of two rrna (rrn) operons of the slow-growing pathogen mycobacterium celatum provides key insights into mycobacterial evolution.the slow-growing mycobacterium celatum is known to have two different 16s rrna gene sequences. this study confirms the presence of two rrn operons and describes their organization. one operon (rrna) was found to be located downstream from mura and the other (rrnb) was found downstream from tyrs. the promoter regions were sequenced, and also the intergenic transcribed spacer (its1 and its2) regions separating the 16s rrna, 23s rrna and 5s rrna gene coding regions. analysis of the rna fraction rev ...200818248431
iris root abscess and necrotizing sclerokeratitis caused by mycobacterium abscessus and presenting as hemorrhagic anterior uveitis.to report a case of an iris abscess and necrotizing sclerokeratitis caused by mycobacterium abscessus and presenting as hemorrhagic uveitis.200818216592
molecular characterization of mycobacterium massiliense and mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures.an outbreak of infections affecting 311 patients who had undergone different invasive procedures occurred in 2004 and 2005 in the city of belém, in the northern region of brazil. sixty-seven isolates were studied; 58 were from patients who had undergone laparoscopic surgeries, 1 was from a patient with a postinjection abscess, and 8 were from patients who had undergone mesotherapy. all isolates were rapidly growing nonpigmented mycobacteria and presented a pattern by pcr-restriction enzyme analy ...200818174307
pseudo-outbreak of mycobacterium abscessus infection caused by laboratory contamination .to investigate the cause(s) of an increased incidence of clinical cultures growing mycobacterium abscessus at a hospital in florida.200818171188
the changing pattern of nontuberculous mycobacterial disease.nontuberculous mycobacteria are human opportunistic pathogens whose source of infection is the environment. these include both slow-growing (eg, mycobacterium kansasii and mycobacterium avium) and rapid-growing (eg, mycobacterium abscessus and mycobacterium fortuitum) species. transmission is through ingestion or inhalation of water, particulate matter or aerosols, or through trauma. the historic presentation of pulmonary disease in older individuals with predisposing lung conditions and in chil ...200318159470
mycobacterium abscessus infection in a case of recurrent orbital implant exposure.exposure is one of the most frequent complications of porous orbital implants, while infection is rarely observed. atypical mycobacteria are ubiquitous germs of mostly variable pathogenicity. a patient with recurrent orbital implant exposure is described, in whom a final diagnosis of mycobacterium abscessus infection was made on culture of the orbital implant remnant at its removal. in orbital implant exposure, infection with unexpected organisms should be considered and in these cases only the ...200718097981
localised pyogranulomatous dermatitis due to mycobacterium abscessus in a cat: a case report.a case of pyogranulomatous dermatitis, caused by mycobacterium abscessus, an unusual opportunistic mycobacterium spp., is described in a cat. histopathological examination of the affected skin confirmed the diagnosis and ziehl-neelsen staining revealed acid-fast rods. a rapidly growing mycobacterium was found after culture on a löwenstein-jensen medium. real-time polymerase chain reaction for the 16s rdna (434bp) sequence and the sequence of the rpob gene (359bp) revealed 99% and 100% matches, r ...200918083608
a case report of mycobacterium abscessus peritonitis in a peritoneal dialysis patient.peritonitis due to nontuberculous mycobacterium in peritoneal dialysis (pd) patients is rare. however, when it occurs, pd catheter removal is required in most cases because of resistance to antibiotic therapy. we report a case of mycobacterium abscessus peritonitis subsequent to tunnel infection after pd catheter-replacement surgery. the patient underwent this surgery as her tunnel infection had not resolved following the usual 3 month course of antibiotic therapy. after surgery, tunnel infectio ...200718028172
microbial substitution of mycobacterium avium-intracellulare to mycobacterium abscessus during clinical course.mycobacterium avium-intracellulare (mai) is, among acid-fast bacilli, the most common cause of nontuberculous pulmonary diseases, and mai infections are often treated according to the guidelines of the american thoracic society. however, despite the use of multiple drugs, patients sometimes do not recover with the initial round of treatment. other kinds of nontuberculous mycobacteria are sometimes found in patients' respiratory samples, even during such treatment for mai pulmonary disease. we ex ...200717982725
decreased cytokine production in patients with nontuberculous mycobacterial lung disease.nontuberculous mycobacteria (ntm) are intracellular pathogens that elicit a specific t-cell response characterized by the production of proinflammatory cytokines, including interferon (ifn)-gamma, tumor necrosis factor (tnf)-alpha, and interleukin (il)-12. however, little information exists regarding the levels of specific cytokines in patients with ntm lung disease. therefore, we compared cytokine production in peripheral blood mononuclear cells (pbmcs) from patients with ntm lung disease with ...200717926095
mycobacterium other than tuberculosis (mott) infection: an emerging disease in infliximab-treated patients.infliximab has revolutionized treatment of rheumatologic diseases and inflammatory bowel disease. however, it increases the risk of tuberculosis. less is known about the development of mycobacterium other than tuberculosis (mott) infection. we review the literature on non-tuberculous mycobacterial infections in infliximab-treated patients and report the first case of disseminated mycobacterium avium complex in an infliximab-treated patient complicated by immune reconstitution inflammatory syndro ...200717920687
successful recovery after disseminated infection due to mycobacterium abscessus in a lung transplant patient: subcutaneous nodule as first manifestation--a case report.mycobacterium abscessus infection following lung transplantation (lt) has been described in a few cases. it is characterized by a variable initial location and subsequent course in this special risk group of patients, particularly those with cystic fibrosis (cf). herein we have presented the case of a patient subjected to lt due to cf, who 1 year after transplantation developed a subcutaneous nodule produced by m abscessus, with subsequent hematogenous spread as well as bronchial and bone marrow ...200717889205
importance of t cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower mycobacterium abscessus in c57bl/6 mice.mycobacterium abscessus is an emerging rapidly growing mycobacterium that causes tuberculous-like lesions in humans. we studied the immune control of this organism in c57bl/6 mice challenged intravenously with 10(7) cfu. bacteria were eliminated from both the spleen and the liver within 90 days, and liver histology showed organized granulomatous lesions. a t- and b-cell requirement was investigated by challenging rag2-/-, cd3epsilon-/-, and mumt-/- mice. rag2-/- and cd3epsilon-/- mice were signi ...200717875636
rapidly growing mycobacteria: clinical and microbiologic studies of 115 cases.we analyzed clinical and microbiologic features of 115 cases involving rapidly growing mycobacteria (rgm) isolated at the university of texas m.d. anderson cancer center, houston (2000-2005) and identified by 16s ribosomal rna gene sequencing analysis. at least 15 rgm species were included: mycobacterium abscessus (43 strains [37.4%]), mycobacterium fortuitum complex (33 strains [28.7%]), and mycobacterium mucogenicum (28 strains [24.3%]) most common, accounting for 90.4%. most m abscessus (32/4 ...200717875513
bilateral deep anterior lamellar keratoplasty for the management of bilateral post-lasik mycobacterial keratitis.a 25-year-old vietnamese man who had bilateral simultaneous laser in situ keratomileusis (lasik) for moderate myopia developed bilateral mycobacterium abscessus keratitis that was treated with intensive medical therapy, flap removal, superficial keratectomy, and, following disease progression, therapeutic deep anterior lamellar keratoplasty (dalk). to our knowledge, this is the first reported case of bilateral post-lasik mycobacterial keratitis successfully treated with dalk.200717720084
prosthetic joint infection due to rapidly growing mycobacteria: report of 8 cases and review of the literature.prosthetic joint infection (pji) due to rapidly growing mycobacteria (rgm) is only occasionally encountered in clinical practice. therefore, the optimal clinical management for this condition is unknown.200717712751
alpha-1-antitrypsin (aat) anomalies are associated with lung disease due to rapidly growing mycobacteria and aat inhibits mycobacterium abscessus infection of macrophages.rapidly growing mycobacteria (rgm) are ubiquitous in the environment but cause lung disease in only a fraction of exposed individuals. this variable susceptibility to disease implies vulnerability to rgm infection due to weakness in host defense. since most persons who contract rgm lung disease have no known host defense defect, it is likely that uncharacterized host deficiencies exist that predispose to rgm infection. alpha-1-antitrypsin (aat) is a host factor that may protect individuals from ...200717654345
in vitro efficacy of imipenem in combination with six antimicrobial agents against mycobacterium abscessus.antimicrobial therapy of mycobacterium abscessus infection is difficult because there are relatively few effective treatment regimens and single-agent therapy frequently fails clinically. in light of the lack of data on the susceptibility profile of m. abscessus strains recovered from infections in japan, the in vitro activity of imipenem in combination with clarithromycin, levofloxacin, moxifloxacin, minocycline, amikacin or tobramycin was investigated by the checkerboard method and compared wi ...200717616451
application of polymerase chain reaction-based restriction fragment length polymorphism in typing ocular rapid-growing nontuberculous mycobacterial isolates from three patients with postoperative endophthalmitis.we describe postoperative endophthalmitis caused by rapid-growing nontuberculous mycobacteria (rgntm) in 3 patients after small-incision cataract surgery with intraocular lens (iol) implantation performed elsewhere and referred to us for management. subsequent identification and confirmation was carried out with biochemical tests and polymerase chain reaction-based restriction fragment length polymorphism (pcr-rflp).200717592326
fish gambler's tenosynovitis caused by mycobacterium marinum: environmental investigation of a fishing pond in southern taiwan.we describe a patient with mycobacterium marinum tenosynovitis associated with a fish spine injury acquired at a gambling fishing pond in southern taiwan and identify the source of the infection. m. marinum was isolated from fishing ponds and underground water and wastewater at the site. the isolates shared the same pulsed-field gel electrophoresis pattern as the patient. m. marinum was not detected in 54 samples obtained from 27 fish. mycobacterium gordonae was isolated from 24 samples collecte ...200717572037
infective crystalline keratopathy secondary to non-tuberculous mycobacterium (mycobacterium abscessus) in a non-traumatized eye. 200717525765
genomics of glycopeptidolipid biosynthesis in mycobacterium abscessus and m. chelonae.the outermost layer of the bacterial surface is of crucial importance because it is in constant interaction with the host. glycopeptidolipids (gpls) are major surface glycolipids present on various mycobacterial species. in the fast-grower model organism mycobacterium smegmatis, gpl biosynthesis involves approximately 30 genes all mapping to a single region of 65 kb.200717490474
atypical mycobacterial infection in patients with cystic fibrosis: update on clinical microbiology methods.while patients with cystic fibrosis (cf) have had dramatic improvement in their survival rates, this has been accompanied by the emergence of more virulent pathogens such as pseudomonas aeruginosa and burkholderia cepacia complex organisms. in addition, there has been emergence of organisms of increasing clinical significance such as the nontuberculous mycobacterial (ntm). although tb infection in patients with cf is extremely uncommon, there is growing concern with regard to atypical mycobacter ...200717451510
a paradigm for the molecular identification of mycobacterium species in a routine diagnostic laboratory.the aim of this study was to improve the identification of mycobacterium species in the context of a uk teaching hospital. real-time pcr assays were established to enable the rapid differentiation between mycobacterium tuberculosis (mtb) complex and mycobacterium species other than tuberculosis (mott), followed by 16s rrna gene sequencing for the speciation of mott. real-time pcr assays gave comparable results to those from the reference laboratory. the implementation of these pcr assays using a ...200717446280
[atypical mycobacteriosis of the skin caused by mycobacterium abscessus in an immunocompetent woman].mycobacterium abscessus is the most pathogenic of the fast-growing mycobacteria, and it is resistant to most of the antimicrobial and tuberculostatic drugs available. this non-tuberculous mycobacterium is significant in medicine because it can contaminate post-traumatic wounds and be a causative agent in chronic skin and soft tissue infection after surgical procedures.a 60-year-old immunocompetent woman was suffering from chronic ulcers and abscesses on the heels and malleoli of both feet. histo ...200717429583
prevalence of gastroesophageal reflux disease in patients with nontuberculous mycobacterial lung disease.knowledge of the relationship between respiratory disorders and gastroesophageal reflux disease (gerd) is increasing. however, the association between gerd and pulmonary disease caused by nontuberculous mycobacteria (ntm) has not been studied in detail. we investigated the prevalence of gerd in patients with the nodular bronchiectatic form of ntm lung disease.200717400680
molecular epidemiology of mycobacterium abscessus, with focus on cystic fibrosis.mycobacterium abscessus has been isolated increasingly often from the respiratory tracts of cystic fibrosis (cf) patients. it is not known whether these organisms are transmitted from person to person or acquired from environmental sources. here, colony morphology and pulsed-field gel electrophoresis (pfge) pattern were examined for 71 isolates of m. abscessus derived from 14 cf patients, three non-cf patients with chronic respiratory m. abscessus infection or colonization, one patient with mast ...200717376883
evaluation of bact/alert 3d sa bottles for accurate detection of mycobacteremia with special reference to mycobacterium abscessus.bacteremia due to mycobacterium abscessus, a rapid grower, belonging to the runyon group iv, occurred in an inpatient with fever of unidentified origin in shinshu university hospital. to the best of our knowledge, this is the first documented case of m. abscessus bacteremia in japan. the organism initially grew on sheep blood agar plates after terminal-subculturing from the bact/alert sa aerobic blood culture bottles with no positive signal, and was subsequently identified as m. abscessus using ...200717363357
pulmonary infection with rapidly growing mycobacteria in a singer with achalasia: a case report.we report the case of a 37-year-old male patient with prolonged pneumonia and achalasia. culture and molecular genetic typing identified mycobacterium abscessus as causative agent. treatment with clarithromycin and minocycline over 8 months gradually resolved the infection. rapidly growing, non-obligate pathogenic mycobacteria are widespread in the environment. several cases of pulmonary infections with these mycobacteria in patients with achalasia have been reported, suggesting a causative asso ...200717316814
paradoxical worsening of pulmonary mycobacterium abscessus.transient worsening of tuberculosis (tb) symptomatology and lesions in response to anti-tb therapy has previously been reported as paradoxical worsening. recently, paradoxical worsening of tb following antiretroviral therapy in aids patients was reported. however, paradoxical worsening of nontuberculous mycobacterium, including mycobacterium abscessus (m. abscessus), has not been reported previously. we reported the first case of paradoxical worsening of pulmonary m. abscessus.200717293101
outbreak of acupuncture-associated cutaneous mycobacterium abscessus infections.cutaneous atypical mycobacterial infections have been increasingly described in association with cosmetic and alternative procedures.200617234114
mycobacterium abscessus infections in lung transplant recipients: the international experience.the clinical significance of mycobacterium abscessus infection in the lung transplant population is not well understood.200617178340
hypervirulence of a rough variant of the mycobacterium abscessus type strain.we isolated a rough variant of mycobacterium abscessus cip 104536t during experimental infection of mice. we show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for c57bl/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.200717145951
[a case of mycobacterium abscessus pulmonary infection; effectiveness of clarithromycin, amikacin and imipenem/cilastatin].a 42-year-old woman presented with persistent cough, bloody sputum and fever. her chest x-ray film showed an infiltrative shadow with cavitation in the upper lobe of the left lung. acid-fast-bacilli were shown by sputum smear staining. the anti-tuberculosis drugs isoniazid, refampicin, ethambutol and pyrazinamide were prescribed, but her symptoms and chest x-ray findings did not improve. findings of mtd and mac-pcr were negative but mycobacterium abscessus was confirmed by sputum culture with th ...200617144576
pathological and molecular studies on mycobacteriosis of milkfish chanos chanos in taiwan.investigated in milkfish chanos chanos, which had a cumulative mortality of up to 66.7% over the course of 1 yr. gross reddish- or greyish-white nodules appeared on the peritoneal surface, spleen, kidney, liver and gastrointestinal (gi) tract. epithelioid granulomas with the formation of langhan's type giant cells were the prominent histopathological changes. despite large numbers of acid-fast bacilli in the granulomas, neither caseous necrosis nor dystrophic calcification were observed. using d ...200617140137
multiple subcutaneous nodules associate with mycobacterium abscessus infection following removal of an infected groshon vascular catheter tip.a 41-year-old man with a history of septic right leg underwent a below-the-knee amputation. one month after amputation and removal of groshon catheter tip, he developed disseminated subcutaneous abscesses attributed to mycobacterium abscessus.200617083867
skin and soft tissue infections due to rapidly growing mycobacteria: comparison of clinical features, treatment, and susceptibility.to compare the demographics, clinical features, susceptibility patterns, and treatment for skin and soft tissue infections due to mycobacterium fortuitum and mycobacterium chelonae or mycobacterium abscessus.200617043183
polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and non-tuberculous mycobacterial lung diseases.interferon-gamma (ifn-gamma) is crucial for host defense against mycobacterial infections. recent studies have indicated that ifn-gamma and ifn-gamma receptor 1 (ifn-gammar1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. the aim of this study was to test the hypothesis that ifn-gamma and ifn-gammar1 gene polymorphisms influence susceptibility to lung disease caused by non-tuberculous mycobacteria (ntm). seventy-six patients with the nodular bronchiectatic form ...200717023216
mycobacterium abscessus endophthalmitis: treatment dilemma and review of the literature. 200616963860
mycobacterium abscessus cervical lymphadenitis: an immunocompetent child.nontuberculous mycobacterium (ntm) is one of the well-known causes of cervicofacial lymphadenopathy in children under 5 years of age. children often present with a painless cervical mass that fails to respond to conventional antibiotics. they are often referred under the suspicion of a neoplasm or bacterial adenitis rather than ntm cervical lymphadenitis. the lack of systemic symptoms, modest or negative purified protein derivative test and absence of exposure to active tuberculosis are characte ...200616911925
pathogenesis of mycobacterium spp. in zebrafish (danio rerio) from research facilities.one of the most common diseases that we have diagnosed in zebrafish is mycobacteriosis, caused by several mycobacterium spp. the severity of the disease ranged from severe outbreaks to incidental infections. we conducted an in vivo study to evaluate the pathogenesis of six isolates of mycobacterium from zebrafish with mycobacteriosis from four research facilities and one wholesale supplier of zebrafish in the united states: mycobacterium abscessus, mycobacterium peregrinum, mycobacterium chelona ...200716904945
mycobacterium abscessus chest wall and pulmonary infection in a cystic fibrosis lung transplant recipient.mycobacterial infections are increasingly recognized in cystic fibrosis (cf) patients before transplant; however, knowledge about the clinical significance or spectrum of infections observed with mycobacterial infections in lung transplant recipients is still evolving. herein, we report a case of infection with mycobacterium abscessus in a cf lung transplant recipient. despite aggressive treatment before and peri-operatively with anti-mycobacterial therapy, the patient developed skin and soft ti ...200616890122
cutaneous infection with rapidly-growing mycobacterial infection following heart transplant: a case report and review of the literature.nontuberculous mycobacteria are ubiquitous and infrequently cause disease in humans, most commonly in immunocompromised hosts. one type of nontuberculous mycobacteria is mycobacterium abscessus. this rapidly growing mycobacterium is a soil or water saprophyte. it was previously classified as a subspecies of mycobacterium chelonae; however, current taxonomy now designates it as a separate species. rapidly growing mycobacteria are resistant to the usual antituberculous drugs. this emphasizes the n ...200616797350
mycobacterium abscessus keratitis after lasik with intralase femtosecond laser.a healthy 38-year-old woman developed 2 white spots in her left eye 2 weeks after bilateral laser in situ keratomileusis (lasik) using the intralase femtosecond laser. initial treatment included levofloxacin 0.5% but was unsuccessful. the surgeon irrigated the interface and repositioned the flap due to a worsened lesion. she was referred to us after the keratitis had not improved. the flap was lifted for collection of the specimen and irrigation of the interface. the keratitis was treated with i ...200616785761
[soft-tissue infections due to non-tuberculous mycobacteria following mesotherapy. what is the price of beauty].mesotherapy is widely used in latin america for cosmetic purposes, particularly in obese individuals. we describe the clinical and epidemiological characteristics, microbiological diagnosis, treatment and follow-up of patients from caracas (venezuela) with soft tissue infection caused by non-tuberculous mycobacteria following mesotherapy.200616762255
spontaneous reversion of mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype.mycobacterium abscessus is an increasingly important cause of human disease; however, virulence determinants are largely uncharacterized. previously, it was demonstrated that a rough, wild-type human clinical isolate (390r) causes persistent, invasive infection, while a smooth isogenic mutant (390s) has lost this capability. during serial passage of 390s, a spontaneous rough revertant was obtained, which was named 390v. this revertant regained the ability to cause persistent, invasive infection ...200616735722
mycobacterium abscessus: an emerging rapid-growing potential pathogen.mycobacterium abscessus is the most pathogenic and chemotherapy-resistant rapid-growing mycobacterium. it is commonly associated with contaminated traumatic skin wounds and with post-surgical soft tissue infections. it is also one of the mycobacteria that are most often isolated from cystic fibrosis patients. it is essential to differentiate this species from the formerly indistinct "m. chelonae-complex", as chemotherapy is especially difficult in m. abscessussenso strictu. clarithromycin or azi ...200616725007
infections due to rapidly growing mycobacteria.rapidly growing mycobacteria, generally of low virulence, are capable of causing a wide spectrum of infections. increasing reports in the literature, referral center experiences, and data from the infectious disease society of america emerging infectious disease network suggest that greater numbers of infections are occurring. epidemiological study is imperative in understanding the true incidence of these infections and preventing disease in vulnerable hosts. especially problematic is pulmonary ...200616705584
partial interferon-gamma receptor deficiency and non-tuberculous mycobacterial lung disease.interferon-gamma (ifn-gamma) plays a key role in the host defense response against mycobacterial disease, and a complete or partial deficiency in ifn-gamma receptor 1 (ifn-gammar1) or ifn-gamma receptor 2 (ifn-gammar2) has been reported to contribute to susceptibility to disseminated infection with non-tuberculous mycobacteria (ntm). however, ifn-gammar1 and ifn-gammar2 deficiencies have not yet been studied in adult patients with isolated ntm lung disease. the purpose of the present study was t ...200616682253
cutaneous infection with mycobacterium abscessus in a child.nontuberculous mycobacteria can cause cutaneous infections in both children and adults. localized nontuberculous mycobacterial infections of the skin have been reported in children following injections or surgical procedures. we report a child who developed a cutaneous nontuberculous mycobacterial infection after exposure of a skin wound to pond water. cutaneous infection with the rapidly growing mycobacteria mycobacterium abscessus was demonstrated by clinical and histologic evaluation on the l ...200616650219
abdominal nontuberculous mycobacterial infection in a university hospital in taiwan from 1997 to 2003.abdominal nontuberculous mycobacterial infection is a rare condition. continuous ambulatory peritoneal dialysis (capd)-associated peritonitis is the most common manifestation of infection due to nontuberculous mycobacteria (ntm). there are limited data on the clinical manifestations of nontuberculous mycobacterial infection. this study investigated the diagnostic features, clinical presentation, mycobacteriology, treatment and outcome of all abdominal ntm infections treated over a 7-year period ...200616638646
fatal pulmonary mycobacterium abscessus infection in a patient using etanercept.a case of fatal pulmonary mycobacterium abscessus infection in a 56-year-old man is reported. the patient had a longstanding history of seropositive, nodular rheumatoid arthritis with severe joint manifestations that had been treated with a regimen of prednisone, leflunomide, and etanercept. he presented to our facility with complaint of productive cough, persistent fevers, pleuritic chest discomfort, and dyspnea at rest. the patient was admitted to hospital, placed in isolation, a left-sided ch ...200616602610
non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation.wc and ns contributed equally. non-tuberculous mycobacteria (ntm) frequently colonise patients with end stage cystic fibrosis (cf), but its impact on the course of the disease following lung transplantation is unknown.200616601086
enterobacterial repetitive intergenic consensus pcr is a useful tool for typing mycobacterium chelonae and mycobacterium abscessus isolates.outbreaks of rapidly growing mycobacterium (rgm) infections are increasingly being reported worldwide. information about genetic relatedness of isolates obtained during outbreaks can provide opportunities for prompt intervention. pulsed-field gel electrophoresis (pfge) is expensive, time consuming, and labor intensive. other than that, mycobacterium abscessus isolates can suffer dna degradation during electrophoresis. polymerase chain reaction (pcr)-based methods are cheaper, faster, and easier ...200616529900
concomitant late soft tissue infections by cladophialophora bantiana and mycobacterium abscessus following tsunami injuries.a swedish man and woman sustained severe soft tissue injuries during the tsunami catastrophe in thailand in december 2004, and subsequently received partial thickness skin grafts after multiple surgical revisions. four to six weeks post trauma they displayed signs of purulent infections in the non-traumatized, virtually intact skin outside the resection margins. skin biopsies revealed granulomatous reactions and pigmented fungal hyphae were observed in specimens from the male patient. cladophial ...200616519023
mycobacterium abscessus pulmonary infection presenting as a solitary pulmonary nodule.nontuberculous mycobacterial pulmonary infection is a rare cause of a solitary pulmonary nodule. all previously reported cases were caused by mycobacterium avium complex, and a solitary pulmonary nodule caused by other ntm species has been very rarely reported. we describe the first case of mycobacterium abscessus infection presenting as a solitary pulmonary nodule in a 51-year-old asymptomatic adult patient.200616508233
clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in korea.precise epidemiologic data regarding nontuberculous mycobacterial (ntm) lung infection in many asian countries have been relatively unavailable. in order to determine the clinical significance of ntm isolated from respiratory specimens, we reviewed medical records from all patients from whom ntm isolates were recovered within a 2-year period.200616478850
effectiveness of fluoroquinolones against mycobacterium abscessus in vivo.to determine the effectiveness of fluoroquinolones against mycobacterium abscessus in vivo.200616421016
use of pcr-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by mycobacterium abscessus and mycobacterium chelonae.skin ulcers, scoliosis, and dropsy-like scale edema were observed in laboratory-maintained zebrafish. affected fish had multifocal granulomas not only in internal organs such as the liver, intestine, genital organs, kidney, muscle, and spleen but also in the fin, epithelium, gills, and sclera of the eyes. large numbers of acid-fast-rod-shaped bacteria were observed within the necrotic centers of well-demarcated, multifocal granulomas with gram's stain and ziehl-neelson's stain. the size of the m ...200616414212
an outbreak of post-acupuncture cutaneous infection due to mycobacterium abscessus.despite the increasing popularity of acupuncture, the importance of infection control is not adequately emphasized in oriental medicine. in december 2001, an oriental medical doctor in seoul, south korea, encountered several patients with persistent, culture-negative skin lesions on the trunk and extremities at the sites of prior acupuncture treatment. we identified and investigated an outbreak of mycobacterium abscessus cutaneous infection among the patients who attended this oriental medicine ...200616412228
sequence variant for internal transcribed spacer region of mycobacterium abscessus. 200516333135
deep stromal mycobacterial keratitis: viable bacteria after six months of treatment: case report and literature review.to report the presence of viable mycobacteria in a patient with keratitis treated for 6 months. species identification was performed using the pra method (polymerase chain reaction followed by restriction endonuclease analysis). clonality was evaluated with rapd (randomly amplified polymorphic dna) and eric-pcr (enterobacterial repetitive intergenic consensus-polymerase chain reaction) methods. the patient reported trauma due to a metallic foreign body 3 weeks prior to presentation. initial corn ...200516322845
[nontuberculous mycobacteria in patients with cystic fibrosis].patients with cystic fibrosis are at great risk of infection by nontuberculous mycobacteria from the environment because of certain predisposing factors such as bronchiectasis, malnutrition, and diabetes. the aim of this study was to analyze the mycobacterial content of sputum smears and cultures from adult patients with cystic fibrosis attended at a specialized unit for adults from march 1997 through december 2001.200516266669
mycobacterium abscessus infection after use of tumor necrosis factor alpha inhibitor therapy: case report and review of infectious complications associated with tumor necrosis factor alpha inhibitor use.tumor necrosis factor alpha (tnf-alpha) inhibitors, such as infliximab and etanercept, are now frequently used in the treatment of inflammatory diseases including rheumatoid arthritis (ra) and crohn's disease. as an apparent result of their immune modulating activity, there has been an observed association between the use of these agents and the development of a wide range of infections, most notably mycobacterium tuberculosis. we describe a case of infection with mycobacterium abscessus in a 67 ...200516249064
thin-section ct findings of nontuberculous mycobacterial pulmonary diseases: comparison between mycobacterium avium-intracellulare complex and mycobacterium abscessus infection.we aimed to compare the ct findings of nontuberculous mycobacterial pulmonary diseases caused by mycobacterium avium-intracellulare complex (mac) and mycobacterium abscessus. two chest radiologists analyzed retrospectively the thin-section ct findings of 51 patients with mac and 36 with m. abscessus infection in terms of patterns and forms of lung lesions. no significant difference was found between mac and m. abscessus infection in the presence of small nodules, tree-in-bud pattern, and bronchi ...200516224151
iatrogenic mycobacterium abscessus infection associated with acupuncture: clinical manifestations and its treatment.mycobacterial infections transmitted by acupuncture are an emerging problem. there have been two reports of mycobacterial infections complicating acupuncture in the english literature.200516207187
pneumonia due to mycobacterium abscessus in two domestic ferrets (mustelo putorius furo).two ferrets were diagnosed with pneumonia due to mycobacterium abscessus. both cases were treated successfully using clarithromycin after positive cultures were obtained via unguided bronchoalveolar lavage. this is the first time m abscessus has been isolated in our laboratory and the first report of this organism causing disease in companion animals in australia. underlying respiratory tract disease was thought to be an important factor in the development of the infections. thorough investigati ...200516164141
mycobacterium chelonae-mycobacterium abscessus complex clear corneal wound infection with recurrent hypopyon and perforation after phacoemulsification and intraocular lens implantation.we report a clear corneal wound infection occurring in a 74-year-old man caused by a member of the mycobacterium chelonae-mycobacterium abscessus complex, presenting as crystalline keratopathy with recurrent hypopyon. this led to perforation after phacoemulsification with posterior chamber intraocular lens implantation. only after corneal biopsy of the incision was the causative organism isolated and found to be sensitive to clarithromycin and ciprofloxacin. despite aggressive therapy, a full-th ...200516105623
clinical, microbiological, and epidemiological findings of an outbreak of mycobacterium abscessus hand-and-foot disease.in 2003, we identified an outbreak of clinically distinct lesions involving the hands and feet associated with a public wading pool in edmonton, alberta, canada. a total of 85 cases were identified. the management and follow-up of 41 children and 1 adult patients is presented. skin lesions occurred within a median incubation period of 29 days and approximately 88 days for the adult patient. lesions resolved within a median of 58 days and approximately 150 days for the adult patient. patients wer ...200516054324
infection with mycobacterium abscessus after mohs micrographic surgery in an immunocompetent patient.nontuberculous mycobacterial infections are increasing in incidence. they have been reported following multiple procedures, including dialysis, liposuction, soft tissue augmentation, pedicures, public baths, acupuncture, placement of contaminated foreign devices such as the norplant (wyeth pharmaceuticals, collegetown, pa, usa), intravenous catheters, and during surgery from contamination of medical instruments.200516029710
in vitro activity of fluoroquinolones against mycobacterium abscessus and mycobacterium chelonae causing infectious keratitis after lasik in brazil.to evaluate the in vitro activity of fluoroquinolones against mycobacterium abscessus and mycobacterium chelonae isolated from outbreaks of infectious keratitis in brazil.200516015094
mycobacterium abscessus and other nontuberculous mycobacteria: evolving respiratory pathogens in cystic fibrosis: a case report and review.cystic fibrosis (cf) is a risk factor for the development of nontuberculous mycobacteria (ntm) infection. prevalence of these organisms varies from center to center with the predominance of affected patients being in the adult population. the difficulty in diagnosing ntm infection in cf involves the overlap between signs and symptoms of underlying cf lung disease with its variable pathogens and the signs and symptoms attributable to pulmonary disease caused by ntm. bacterial overgrowth, especial ...200516004174
nramp1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases.pulmonary disease caused by nontuberculous mycobacteria (ntm) may occur in patients with no underlying lung disease and no known immunodeficiency. the purpose of this study was to evaluate a potential role for natural-resistance-associated macrophage protein 1 (nramp1) gene polymorphisms for human susceptibility to the ntm lung disease.200516002921
intra- and interpatient variability of the hsp65 and 16s-23s intergenic gene region in mycobacterium abscessus strains from patients with cystic fibrosis.to establish the exact pathogenic role of mycobacterium abscessus in cystic fibrosis (cf), molecular tests are required for accurate identification. forty-eight m. abscessus isolates from seven patients with cf were analyzed by sequence analysis for sequence variants within the hsp65 gene and the 16s-23s intergenic sequence (its). we detected two different hsp65 genes and correspondingly two its sequevars belonging to m. abscessus type i and type ii.200516000490
age-related prevalence and distribution of nontuberculous mycobacterial species among patients with cystic fibrosis.we studied the prevalence and species distribution of nontuberculous mycobacteria (ntm) in relation to age in 385 patients with cystic fibrosis (cf) (mean age +/- standard deviation [range], 12.0 +/- 6.1 [1 to 24] years; sex ratio, 0.53) attending three parisian centers. the overall prevalence of ntm in sputum was 8.1% (31 out of 385). the following ntm were isolated (n = 33): mycobacterium abscessus (n = 13, 39.4%), mycobacterium avium complex (mac) (n = 7, 21.2%), mycobacterium gordonae (n = 6 ...200516000480
mycobacteria abscessus outbreak in us patients linked to offshore surgicenter.we recently encountered 5 patients with mycobacterium abscessus infection following cosmetic procedures performed at a surgicenter located off the united states coastline which, by report, actively recruits domestic patients. additional patients with similar clinical histories and presentation have been identified at other practices along the eastern seaboard as well. a recent centers for disease control and prevention investigation has confirmed a common link. all procedures were performed in s ...200515985802
[two cases of pulmonary infection by mycobacterium abscessus in which drug susceptibility testing results conflicted with clinical courses].we encountered two cases of pulmonary infection by mycobacterium abscessus (m. abscessus). [case 1] a 66-year-old man who had been treated for non-tuberculous mycobacterium in the past was admitted because of productive cough. his chest x-ray film showed cavitation and direct microscopy of sputum revealed positive acid-fast bacilli (afb). he was given rifampicin (rfp), ethambutol (eb), and clarythromycin (cam), and then his symptoms and radiographic findings improved. [case 2] a 74-year-old man ...200515966372
osteomyelitis of the mandible due to mycobacterium abscessus: a case report. 200515944984
completion pneumonectomy for chronic mycobacterial disease.patients with persistent pulmonary infections from mycobacterial disease present a difficult clinical challenge. these individuals typically have poor pulmonary function, malnutrition, and other comorbidities, and few guidelines exist regarding optimal therapy. we report our experience with completion pneumonectomy as part of a multidisciplinary treatment program for patients with recurrent, persistent mycobacterial disease.200515942565
Refresh
firstprev
12345678910...
nextlast
Displaying items 801 - 900 of 1047