Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| motor learning in common marmosets: vestibulo-ocular reflex adaptation and its sensitivity to inhibitors of purkinje cell long-term depression. | adaptation of the horizontal vestibulo-ocular reflex (hvor) provides an experimental model for cerebellum-dependent motor learning. we developed an eye movement measuring system and a paradigm for induction of hvor adaptation for the common marmoset. the hvor gain in dark measured by 10° (peak-to-peak amplitude) and 0.11-0.5hz turntable oscillation was around unity. the gain-up and gain-down hvor adaptation was induced by 1h of sustained out-of-phase and in-phase 10°-0.33hz combined turntable-sc ... | 2014 | 24768746 |
| birth of healthy offspring following icsi in in vitro-matured common marmoset (callithrix jacchus) oocytes. | intracytoplasmic sperm injection (icsi), an important method used to treat male subfertility, is applied in the transgenic technology of sperm-mediated gene transfer. however, no study has described successful generation of offspring using icsi in the common marmoset, a small non-human primate used as a model for biomedical translational research. in this study, we investigated blastocyst development and the subsequent live offspring stages of marmoset oocytes matured in vitro and fertilized by ... | 2014 | 24751978 |
| experimental infection of rhesus macaques and common marmosets with a european strain of west nile virus. | west nile virus (wnv) is a mosquito-borne flavivirus that infects humans and other mammals. in some cases wnv causes severe neurological disease. during recent years, outbreaks of wnv are increasing in worldwide distribution and novel genetic variants of the virus have been detected. although a substantial amount of data exists on wnv infections in rodent models, little is known about early events during wnv infection in primates, including humans. to gain a deeper understanding of this process, ... | 2014 | 24743302 |
| antidromic latency of magnocellular, parvocellular, and koniocellular (blue-on) geniculocortical relay cells in marmosets. | we studied the functional connectivity of cells in the lateral geniculate nucleus (lgn) with the primary visual cortex (v1) in anesthetized marmosets (callithrix jacchus). the lgn sends signals to v1 along parallel visual pathways called parvocellular (p), magnocellular (m), and koniocellular (k). to better understand how these pathways provide inputs to v1, we antidromically activated relay cells in the lgn by electrically stimulating v1 and measuring the conduction latencies of p (n = 7), m (n ... | 2014 | 24703370 |
| cd20+ b cell depletion alters t cell homing. | depleting mabs against the pan b cell marker cd20 are remarkably effective in the treatment of autoimmune-mediated inflammatory disorders, but the underlying mechanisms are poorly defined. the primary objective of this study was to find a mechanistic explanation for the remarkable clinical effect of the anti-cd20 mabs in a representative nonhuman primate autoimmune-mediated inflammatory disorder model, experimental autoimmune encephalomyelitis (eae) in common marmosets, allowing detailed analysi ... | 2014 | 24696233 |
| reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. | the common marmoset (callithrix jacchus) is a new world primate sharing many similarities with humans. recently developed technology for generating transgenic marmosets has opened new avenues for faithful recapitulation of human diseases, which could not be achieved in rodent models. however, the longer lifespan of common marmosets compared with rodents may result in an extended period for in vivo analysis of common marmoset disease models. therefore, establishing rapid and efficient techniques ... | 2014 | 24694048 |
| a novel primate es cell line from the common marmoset (callithrix jacchus) exhibits germ cell development in vitro. | 2007 | 24692918 | |
| fatal cowpox virus infection in cotton-top tamarins (saguinus oedipus) in germany. | cowpox virus (cpxv) was isolated from a fatal outbreak among cotton-top tamarins. samples from healthy common marmosets in contact were also cpxv genome positive. the cpxv isolated from the cotton-top tamarins exhibited a unique hemagglutinin sequence. pathogenicity investigations using a wistar rat model characterized the isolate as low pathogenic. | 2014 | 24689730 |
| adenosine a₂a-receptor antagonist istradefylline enhances the motor response of l-dopa without worsening dyskinesia in mptp-treated common marmosets. | the adenosine a₂a-receptor antagonist istradefylline decreases off time in patients with parkinson's disease who are already treated with optimal doses of dopaminergic medication but can cause an increase in non-troublesome dyskinesia. preclinical experiments have shown that a₂a antagonists are most effective in potentiating motor function when combined with sub-maximal doses of l-dopa. however, the effects of combining istradefylline with sub-optimal l-dopa treatment on established dyskinesia h ... | 2014 | 24681641 |
| semen characteristics of captive common marmoset (callithrix jacchus): a comparison of a german with a brazilian colony. | the common marmoset (callithrix jacchus) is of interest for reproductive studies because of their high and variable fertility in captivity. however, to understand this variability, much basic information still needs to be gathered. this study is the first to characterize marmoset semen comparing a german and a brazilian colony. | 2014 | 24673563 |
| primate short-wavelength cones share molecular markers with rods. | macaca, callithrix jacchus marmoset monkey, pan troglodytes chimpanzee and human retinas were examined to define if short wavelength (s) cones share molecular markers with l&m cone or rod photoreceptors. s cones showed consistent differences in their immunohistochemical staining and expression levels compared to l&m cones for "rod" arrestin1 (s-antigen), "cone" arrestin4, cone alpha transducin, and calbindin. our data verify a similar pattern of expression in these primate retinas and provide cl ... | 2014 | 24664680 |
| analysis of essential pathways for self-renewal in common marmoset embryonic stem cells. | common marmoset (cm) is widely recognized as a useful non-human primate for disease modeling and preclinical studies. thus, embryonic stem cells (escs) derived from cm have potential as an appropriate cell source to test human regenerative medicine using human escs. cm escs have been established by us and other groups, and can be cultured in vitro. however, the growth factors and downstream pathways for self-renewal of cm escs are largely unknown. in this study, we found that basic fibroblast gr ... | 2014 | 24649403 |
| a modified light-dark box test for the common marmoset. | the common marmoset (callithrix jacchus) has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. however, behavioral test methods are still limited in the field of marmoset research. the light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. here, we modified the light-dark test to study this behavior. the modified apparatus ... | 2014 | 24638903 |
| identification of a pathway from the retina to koniocellular layer k1 in the lateral geniculate nucleus of marmoset. | three well characterized pathways in primate vision (midget-parvocellular, parasol-magnocellular, bistratified-koniocellular) have been traced from the first synapse in the retina, through the visual thalamus (lateral geniculate nucleus, lgn), to the visual cortex. here we identify a pathway from the first synapse in the retina to koniocellular layer k1 in marmoset monkeys (callithrix jacchus). particle-mediated gene transfer of an expression plasmid for the postsynaptic density 95-green fluores ... | 2014 | 24623761 |
| oestradiol modulation of cognition in adult female marmosets (callithrix jacchus). | the common marmoset (callithrix jacchus) provides many advantages over traditional rodent and macaque species as a model for human ageing and may be very useful for studying the effects of sex steroids on cognitive and brain ageing. we present the first study examining the effects of oestrogens on cognitive function in female marmosets. adult monkeys (3-5 years of age) were trained to a specific learning criterion on a battery of cognitive tasks preoperatively (object discrimination, delayed res ... | 2014 | 24617856 |
| genomic sequence analysis of the mhc class i g/f segment in common marmoset (callithrix jacchus). | the common marmoset (callithrix jacchus) is a new world monkey that is used frequently as a model for various human diseases. however, detailed knowledge about the mhc is still lacking. in this study, we sequenced and annotated a total of 854 kb of the common marmoset mhc region that corresponds to the hla-a/g/f segment (caja-g/f) between the caja-g1 and rnf39 genes. the sequenced region contains 19 mhc class i genes, of which 14 are of the mhc-g (caja-g) type, and 5 are of the mhc-f (caja-f) ty ... | 2014 | 24600031 |
| gross morphometry of the heart of the common marmoset. | the callithrix jacchus is a brazilian endemic species that has been widely used as an experimental model in biomedical research. anatomical data are necessary to support experimental studies with this species. eleven hearts of c. jacchus from the german primate centre (dpz) have been studied in order to characterize their gross morphometry and compare them with other animal models and human. biometric data were also obtained. the mean values for morphometry of the hearts did not show any signifi ... | 2014 | 24590521 |
| polymeric nanoparticle formulation of octapeptide (np-op): in vitro release and in vivo effect in common marmosets, callithrix jacchus linn. | octapeptide (op)/fsh-receptor binding inhibitor-8 (frbi-8), is a synthetic peptide corresponding to n-terminal sequence of purified fraction of follicle stimulating hormone binding-inhibitor (fshbi), isolated earlier from human ovarian follicular-fluid. in order to avoid the repeated drug-administration, op-loaded, polymeric polylactide (pla) nanoparticle formulation (np-op), was developed using multiple-emulsion technique. this yielded an average particle size of 120 nm with 70% encapsulation-e ... | 2013 | 24579370 |
| exceptional expansion and conservation of a ct-repeat complex in the core promoter of paxbp1 in primates. | adaptive evolution may be linked with the genomic distribution and function of short tandem repeats (strs). proximity of the core promoter strs to the +1 transcription start site (tss), and their mutable nature are characteristics that highlight those strs as a novel source of interspecies variation. the paxbp1 gene (alternatively known as gcfc1) core promoter contains the longest str identified in a homo sapiens gene core promoter. indeed, this core promoter is a stretch of four consecutive ct- ... | 2014 | 24573656 |
| responses towards a dying adult group member in a wild new world monkey. | compassionate caretaking behaviour towards dying adult group members has been reported as being unique to humans and chimpanzees. here we describe in detail the reaction of a wild dominant male common marmoset, a neotropical primate, to the accidental death of the dominant female of its group. the male exhibited behaviours towards the dying female that resembled those of chimpanzees and humans. the long-term relationship between the dominant pair (which lasted at least 3.5 years) and their socia ... | 2014 | 24566801 |
| distribution of ciliated epithelial cells in the trachea of common marmosets (callithrix jacchus). | the distribution of ciliated cells in the tracheal epithelium of common marmosets was evaluated. | 2014 | 24536099 |
| differences in aerosolization of rift valley fever virus resulting from choice of inhalation exposure chamber: implications for animal challenge studies. | the aerosol characteristics of rift valley fever virus (rvfv) were evaluated to achieve reproducible infection of experimental animals with aerosolized rvfv suitable for animal efficacy studies. spray factor (sf), the ratio between the concentrations of the aerosolized agent to the agent in the aerosol generator, is used to compare performance differences between aerosol exposures. sf indicates the efficiency of the aerosolization process; a higher sf means a lower nebulizer concentration is nee ... | 2014 | 24532259 |
| osteogenic induction from marmoset embryonic stem cells cultured in feeder-dependent and feeder-independent conditions. | embryonic stem cells (escs) have become increasingly attractive for cell replacement therapies of osteodegenerative diseases; however, pre-clinical studies in large animal models to repair diseased or injured bone are lacking. as a first step into this direction, we describe here the feeder-free cultivation and directed osteogenic differentiation of marmoset escs. | 2014 | 24531422 |
| characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. | recent generation of induced pluripotent stem (ipscs) has made a significant impact on the field of human regenerative medicine. prior to the clinical application of ipscs, testing of their safety and usefulness must be carried out using reliable animal models of various diseases. in order to generate ipscs from common marmoset (cm; callithrix jacchus), one of the most useful experimental animals, we have lentivirally transduced reprogramming factors, including pou5f1 (also known as oct3/4), sox ... | 2014 | 24521492 |
| characterization of common marmoset (callithrix jacchus) bone marrow-derived mesenchymal stem cells. | mesenchymal stem cells (mscs) could be useful for regenerative medicine because they can beharvested easily from the bone marrow of living donors and the cells can be differentiated into adipogenic, osteogenic, and chondrogenic lineages in vitro. to apply mscs for the medical treatment of human diseases as regenerative medicine, detailed experimental characterization of the cells is required. recently, a new world primate, the common marmoset (callithrix jacchus), has been widely used as a new h ... | 2013 | 24497134 |
| developmental expression profiles of axon guidance signaling and the immune system in the marmoset cortex: potential molecular mechanisms of pruning of dendritic spines during primate synapse formation in late infancy and prepuberty (i). | the synapse number and the related dendritic spine number in the cerebral cortex of primates shows a rapid increase after birth. depending on the brain region and species, the number of synapses reaches a peak before adulthood, and pruning takes place after this peak (overshoot-type synaptic formation). human mental disorders, such as autism and schizophrenia, are hypothesized to be a result of either too weak or excessive pruning after the peak is reached. thus, it is important to study the mol ... | 2014 | 24485715 |
| active vision in marmosets: a model system for visual neuroscience. | the common marmoset (callithrix jacchus), a small-bodied new world primate, offers several advantages to complement vision research in larger primates. studies in the anesthetized marmoset have detailed the anatomy and physiology of their visual system (rosa et al., 2009) while studies of auditory and vocal processing have established their utility for awake and behaving neurophysiological investigations (lu et al., 2001a,b; eliades and wang, 2008a,b; osmanski and wang, 2011; remington et al., 2 ... | 2014 | 24453311 |
| development of novel mechanisms for housing, handling, and remote monitoring of common marmosets at animal biosafety level 3. | the use of common marmosets as an alternative non-human primate model for infectious disease research using bsl-3 viruses such as rift valley fever virus (rvfv) presents unique challenges with respect to housing, handling, and safety. subject matter experts from veterinary care, animal husbandry, biosafety, engineering, and research were consulted to design a pilot experiment using marmosets infected with rvfv. this paper reviews the caging, handling, and safety-related adaptations and modificat ... | 2014 | 24453160 |
| uwa-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances l-dopa anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the mptp-lesioned common marmoset. | l-3,4-dihydroxyphenylalanine (l-dopa) is the most effective treatment for parkinson's disease (pd), but its long-term administration is complicated by wearing-off and dyskinesia. uwa-101, a dual, equipotent inhibitor of dopamine (dat) and serotonin (sert) transporters, has previously been shown to successfully extend duration of anti-parkinsonian benefit of l-dopa (on-time), without exacerbating dyskinesia, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmoset. however, uw ... | 2014 | 24447715 |
| developmental genetic profiles of glutamate receptor system, neuromodulator system, protector of normal tissue and mitochondria, and reelin in marmoset cortex: potential molecular mechanisms of pruning phase of spines in primate synaptic formation process during the end of infancy and prepuberty (ii). | this is the second report of a series paper, which reports molecular mechanisms underlying the occurrence of pruning spine phase after rapid spinogenesis phase in neonates and young infant in the primate brain. we performed microarray analysis between the peak of spine numbers [postnatal 3 months (m)] and spine pruning (postnatal 6m) in prefrontal, inferior temporal, and primary visual cortices of the common marmoset (callithrix jacchus). the pruning phase is not clearly defined in rodents but i ... | 2014 | 24440696 |
| twinning and survivorship of captive common marmosets (callithrix jacchus) and cotton-top tamarins (saguinus oedipus). | here we present the results of a demographic analysis of 25 y (1985 to 2010) of common marmoset (callithrix jacchus) and cotton-top tamarin (saguinus oedipus) records from the new england primate research center. summaries of longevity and survivorship are analyzed by birth-type category (including singletons, twins, triplets, and quadruplets) and sex. in addition, a brief evolutionary review is presented. surrogates of hematopoietic chimerism, twinning, and reproductive output are explored in a ... | 2014 | 24411773 |
| evolution of mammalian opn5 as a specialized uv-absorbing pigment by a single amino acid mutation. | opn5 is one of the recently identified opsin groups that is responsible for nonvisual photoreception in animals. we previously showed that a chicken homolog of mammalian opn5 (opn5m) is a gi-coupled uv sensor having molecular properties typical of bistable pigments. here we demonstrated that mammalian opn5m evolved to be a more specialized photosensor by losing one of the characteristics of bistable pigments, direct binding of all-trans-retinal. we first confirmed that opn5m proteins in zebrafis ... | 2014 | 24403072 |
| motor assessment of developing common marmosets. | motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. however, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. the common marmoset (callithrix jacchus), a small new world monkey, has recently attracted much attention as a potential nonhuman primate model for understanding human physiology and diseases. however, little is known about ... | 2014 | 24395453 |
| do newborn vocalizations affect the behavioral and hormonal responses of nonreproductive male common marmosets (callithrix jacchus)? | parental care in mammals is influenced by sensory stimuli from infants, such as sight and sound, and by changes in the hormone levels of caretakers. to determine the responsiveness of common marmoset (callithrix jacchus) adult males with and without previous experience in caretaking to newborn sensory cues, we exposed twelve males to infant vocalization recordings and assessed their hormonal and behavioral responses. males were placed in the testing cage for 10 min under two conditions: (a) cont ... | 2014 | 24394953 |
| the role of omega-3 polyunsaturated fatty acid-enriched diets in the prevention of ventricular fibrillation. | in a number of epidemiological surveys and in two recent intervention trials in cardiac patients, diets rich in marine omega-3 polyunsaturated fatty acids (pufa), which include both eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), have been found to be beneficial in reducing the susceptibility of developing serious ventricular fibrillation (vf) or malignant cardiac dysrhythmia and mortality from sudden cardiac death (scd). in addition to this information from human studies, there is s ... | 1999 | 24394167 |
| common marmoset as a new model animal for neuroscience research and genome editing technology. | the common marmoset (callithrix jacchus) is a small new world primate; it originally comes from the atlantic coastal forests in northeastern brazil. it has been attracting much attention in the biomedical research field because of its size, availability, and unique biological characteristics. its endocrinological and behavioral similarity to humans, comparative ease in handling, and high reproductive efficiency are very advantageous for neuroscience research. recently, we developed transgenic co ... | 2014 | 24387631 |
| evolutionary genetics and implications of small size and twinning in callitrichine primates. | new world monkeys (nwms) are characterized by an extensive size range, with clawed nwms (subfamily callitrichinae, or callitrichines) such as the common marmoset manifesting diminutive size and unique reproductive adaptations. perhaps the most notable of these adaptations is their propensity toward multiple gestations (i.e., dichorionic twins and trichorionic triplets). indeed, with the exception of goeldi's monkey (callimico), callitrichine singleton pregnancies rarely occur. multiple gestation ... | 2014 | 24379383 |
| using snacks high in fat and protein to improve glucoregulatory function in adolescent male marmosets (callithrix jacchus). | the common marmoset (callithrix jacchus), a laboratory nonhuman primate, is a well-known model of several human diseases and conditions, but the nutritional needs of these animals are not fully understood. here we describe a 4-mo controlled study in which we increased the dietary fat and protein of subadult male common marmosets by using healthy snacks. six male marmosets received their normal diet (control), and an additional 6 were given their normal diet supplemented daily with a 14-kcal snac ... | 2013 | 24351764 |
| aerosolized rift valley fever virus causes fatal encephalitis in african green monkeys and common marmosets. | rift valley fever (rvf) is a veterinary and human disease in africa and the middle east. the causative agent, rvf virus (rvfv), can be naturally transmitted by mosquito, direct contact, or aerosol. we sought to develop a nonhuman primate (nhp) model of severe rvf in humans to better understand the pathogenesis of rvf and to use for evaluation of medical countermeasures. nhp from four different species were exposed to aerosols containing rvfv. both cynomolgus and rhesus macaques developed mild fe ... | 2014 | 24335307 |
| serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset. | the increasing use of the common marmoset (callithrix jacchus) in research makes it important to diagnose spontaneous disease that may confound experimental studies. bone disease and gastrointestinal disease are two major causes of morbidity and mortality in captive marmosets, but currently no effective antemortem tests are available to identify affected animals prior to the terminal stage of disease. in this study we propose that bone disease and gastrointestinal disease are associated disease ... | 2013 | 24324827 |
| demonstration of marmosets (callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans. | there are four dengue virus (denv) serotypes. primary infection with one does not confer protective immunity against the others. we have reported previously that the marmoset (callithrix jacchus) is a useful primary denv infection model. it has been reported that secondary denv infection with a heterotypic serotype induces viraemia kinetics and antibody responses that differ from those in primary infection. thus, it is important to determine the utility of the marmoset as a model for secondary d ... | 2014 | 24323638 |
| lack of dopamine d4 receptor affinity contributes to the procognitive effect of lurasidone. | we previously demonstrated among several antipsychotics exhibiting potent dopamine d2 receptor antagonism that only lurasidone, (1r,2s,3r,4s)-n-[(1r,2r)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyclohexylmethyl]-2,3-bicyclo[2.2.1] heptanedicarboximide hydrochloride, improved performance in the object retrieval detour (ord) task by marmosets. the mechanisms by which only lurasidone causes enhancements in cognitive function have not yet been established; however, most antipsychotics, ... | 2014 | 24304719 |
| auditory artificial grammar learning in macaque and marmoset monkeys. | artificial grammars (ag) are designed to emulate aspects of the structure of language, and ag learning (agl) paradigms can be used to study the extent of nonhuman animals' structure-learning capabilities. however, different ag structures have been used with nonhuman animals and are difficult to compare across studies and species. we developed a simple quantitative parameter space, which we used to summarize previous nonhuman animal agl results. this was used to highlight an under-studied ag with ... | 2013 | 24285889 |
| characterization of circulating natural killer cells in neotropical primates. | despite extensive use of nonhuman primates as models for infectious diseases and reproductive biology, imprecise phenotypic and functional definitions exist for natural killer (nk) cells. this deficit is particularly significant in the burgeoning use of small, less expensive new world primate species. using polychromatic flow cytometry, we identified peripheral blood nk cells as cd3-negative and expressing a cluster of cell surface molecules characteristic of nk cells (i.e., nkg2a, nkp46, nkp30) ... | 2013 | 24244365 |
| a novel nonhuman primate model for influenza transmission. | studies of influenza transmission are necessary to predict the pandemic potential of emerging influenza viruses. currently, both ferrets and guinea pigs are used in such studies, but these species are distantly related to humans. nonhuman primates (nhp) share a close phylogenetic relationship with humans and may provide an enhanced means to model the virological and immunological events in influenza virus transmission. here, for the first time, it was demonstrated that a human influenza virus is ... | 2013 | 24244352 |
| fetal sulcation and gyrification in common marmosets (callithrix jacchus) obtained by ex vivo magnetic resonance imaging. | the present study characterized fetal sulcation patterns and gyrification in the cerebrum of the new world monkey group, common marmosets, using a 3d t2-weighted high-resolution anatomical magnetic resonance imaging (mri) sequence from the fixed brain at 7-tesla ex vivo. fetal sulcation in the marmoset cerebrum began to indent the lateral fissure and hippocampal sulcus in gestational week (gw) 12, and then the following sulci emerged: the callosal and calcarine sulci on gw 15; the superior tempo ... | 2014 | 24220690 |
| phylogenetic analysis and positive-selection site detecting of vascular endothelial growth factor family in vertebrates. | vascular endothelial growth factor (vegf), known to play an important role in vascular homeostasis, vascular integrity and angiogenesis, is little known about the evolutionary relationship of its five members especially the role of gene duplication and natural selection in the evolution of the vegf family. in this study, seventy-five full-length cdna sequences from 33 vertebrate species were extracted from the ncbi's genbank, uniprot protein database and the ensembl database. by phylogenetic ana ... | 2014 | 24200960 |
| grafting of neonatal marmoset monkey testicular single-cell suspensions into immunodeficient mice leads to ex situ testicular cord neomorphogenesis. | single-cell suspensions derived from immature rodent and ungulate testes can reconstitute testicular cords upon grafting into immunodeficient mice. in the present study, neonatal common marmoset monkey (callithrix jacchus) testes were digested to a single-cell suspension, which was transplanted subcutaneously into immunodeficient mice. after 9 or 18 weeks of incubation, the derivatives of the grafted single-cell suspensions were retrieved and analyzed histologically and immunohistochemically. th ... | 2013 | 24192033 |
| spontaneous malignant t cell lymphoma in a young male common marmoset (callithrix jacchus). | we histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcutaneous nodules near the right breast and an approximately fivefold increase in peripheral lymphocyte count compared with the previous examination value. the postmortem findings at two years eight month ... | 2013 | 24155563 |
| proteomic analysis of striatum from mptp-treated marmosets (callithrix jacchus) with l-dopa-induced dyskinesia of differing severity. | marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and treated with l-3,4-dihydroxyphenylalanine (l-dopa) develop dyskinesia, but with differing degrees of severity. to provide insight into the molecular mechanisms responsible for the different level of dyskinesia to manifest in individual animals, proteins in striatum from mptp-treated marmosets with different levels of l-dopa-induced dyskinesia were separated by 2-dimensional (2-d) protein electrophoresis. ... | 2014 | 24150990 |
| mechanical output in jumps of marmosets (callithrix jacchus). | in this study we determined the mechanical output of common marmosets (callithrix jacchus) during jumping. vertical ground reaction forces were measured in 18 animals while they jumped from an instrumented crossbar to a crossbar located 70 cm higher. from the vertical force time histories, we calculated the rate of change of mechanical energy of the centre of mass (de/dt). the mean value of de/dt during the push-off amounted to 51.8±6.2 w kg(-1) body mass, and the peak value to 116.4±17.6 w kg(- ... | 2014 | 24143030 |
| large-scale brain networks in the awake, truly resting marmoset monkey. | resting-state functional mri is a powerful tool that is increasingly used as a noninvasive method for investigating whole-brain circuitry and holds great potential as a possible diagnostic for disease. despite this potential, few resting-state studies have used animal models (of which nonhuman primates represent our best opportunity of understanding complex human neuropsychiatric disease), and no work has characterized networks in awake, truly resting animals. here we present results from a smal ... | 2013 | 24133280 |
| infection of common marmosets with hepatitis c virus/gb virus-b chimeras. | the development of vaccination and novel therapy for hepatitis c virus (hcv) has been hampered by the lack of suitable small-animal models. gb virus b (gbv-b), closely related to hcv, causes viral hepatitis in common marmosets (callithrix jacchue jacchus) and might represent an attractive surrogate model for hcv infection. however, differences exist between gbv-b and hcv in spite of a short genetic distance between the two viruses. here we report common marmosets infected with two hcv/gbv-b chim ... | 2014 | 24123143 |
| atypical cilia in the respiratory tract of common marmosets (callithrix jacchus) with and without concurrent lung disease. | ciliated cells of the respiratory epithelium play an essential role in the mechanisms of mucociliary clearance, and ultrastructural alterations of cilia are known to be associated with respiratory disease. the aim of this study was to evaluate the presence of ciliary changes in common marmosets (callithrix jacchus) of different age groups and to compare healthy animals with animals suffering from subclinical chronic inflammatory pulmonary lesions. therefore, samples of different sites of the tra ... | 2013 | 24102386 |
| in vivo manipulation of γ9(+) t cells in the common marmoset (callithrix jacchus) with phosphoantigen and effect on the progression of respiratory melioidosis. | burkholderia pseudomallei is a dangerous human pathogen. phosphoantigens specifically the target primate specific γ9(+)δ2(+) t cells subset and some have been developed as potential immunotherapeutics. previously, we demonstrated that, when stimulated with the phosphoantigen chdmapp, γ9(+)δ2(+) t cells aid in the killing of intracellular b. pseudomallei bacteria. moreover, we found that common marmoset (callithrix jacchus) γ9(+) t cells increase in frequency and respond to the phosphoantigen chd ... | 2013 | 24098670 |
| selection of suitable reference genes for mrna quantification studies using common marmoset tissues. | the common marmoset (callithrix jacchus) is increasingly being used as a non-human primate animal model in biomedical research. to perform accurate quantitative analysis of gene expression by quantitative reverse transcription polymerase chain reaction, reliable reference genes should be selected. in this study, we evaluated the expressions of 11 widely used reference genes: actb, atp5f1, b2m, gapdh, hprt1, pgk1, ppia, rn18s1, rplp0, tbp and ubc in 12 tissues and five brain areas of healthy comm ... | 2013 | 24068436 |
| thyroid follicular adenoma with accumulation of collagen type iv in a common marmoset (callithrix jacchus). | a thyroid tumour was identified in a 10-year-old male common marmoset (callithrix jacchus). the tumour was encapsulated by fibrous connective tissue and compressed the adjacent normal thyroid. the tumour was composed of variably sized and irregularly shaped thyroid follicles lined by a single layer of columnar epithelial cells. eosinophilic material at the base of the neoplastic cells stained black with periodic acid-methenamine silver and red with periodic acid-schiff. immunohistochemistry conf ... | 2014 | 24060155 |
| enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and coup-tfii. | cone photopigments (opsins) are crucial elements of, and the first detection module in, color vision. individual opsins have different wavelength sensitivity patterns, and the temporal and spatial expression patterns of opsins are unique and stringently regulated. long and middle wavelength-sensitive (l/m) opsins are of the same phylogenetic type. although the roles of thyroid hormone/trß2 and coup-tfs in the transcriptional regulation of l/m opsins have been explored, the detailed mechanisms, i ... | 2013 | 24058409 |
| hair trace elementary profiles in aging rodents and primates: links to altered cell homeodynamics and disease. | aging is associated with an increased incidence of pathological conditions such as neurodegeneration, cardiovascular and renal disease, and cancer. these conditions are believed to be linked to a disruption in cell homeodynamics, which is regulated by essential trace elements. in this study we used hair elementary analysis by inductively coupled plasma mass spectrometry (icpms) to examine age-related profiles of 47 elements in both rats and common marmoset monkeys. hair was collected from young ... | 2013 | 24057279 |
| characterization of plasma thiol redox potential in a common marmoset model of aging. | due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (callithrix jacchus) is poised to become a standard nonhuman primate model of aging. blood and extracellular fluid possess two major thiol-dependent redox nodes involving cysteine (cys), cystine (cyss), glutathione (gsh) and glutathione disulfide (gssg). alteration in these plasma redox nodes significantly affects cellular physiology, and oxidation of the plasma cys/cyss r ... | 2013 | 24024176 |
| the repertoire of mhc class i genes in the common marmoset: evidence for functional plasticity. | in humans, the classical antigen presentation function of major histocompatibility complex (mhc) class i molecules is controlled by the human leukocyte antigen hla -a, hla-b and hla-c loci. a similar observation has been made for great apes and old world monkey species. in contrast, a new world monkey species such as the cotton-top tamarin (saguinus oedipus) appears to employ the g locus for its classical antigen presentation function. at present, little is known about the classical mhc class i ... | 2013 | 24018468 |
| individual differences in choice (in)flexibility but not impulsivity in the common marmoset: an automated, operant-behavior choice task. | individual differences in behavioural flexibility are a significant issue in human psychopathology as well as in its animal models. we aimed to investigate individual variations of operant-choice behaviour in the common marmoset (callithrix jacchus), a small new world primate, using a new operant panel with two hand-poking holes. | 2013 | 24016838 |
| the development of obesity begins at an early age in captive common marmosets (callithrix jacchus). | animal models to study the causes and consequences of obesity during infancy in humans would be valuable. in this study, we examine the patterns of fat mass gain from birth to 12 months in common marmosets (callithrix jacchus). lean and fat mass was measured by quantitative magnetic resonance at 1, 2, 6, and 12 months for 31 marmosets, 15 considered normal and 16 considered fat (> 14% body fat) at 12 months. animals were fed either the regular colony diet mix or a high-fat variation. subjects cl ... | 2012 | 24006544 |
| effect of the size of zona pellucida opening on hatching in the common marmoset monkey (callithrix jacchus) embryo. | the use of the common marmoset monkey in biomedical research has increased recently, and further attention has been devoted to this model after the successful production of transgenic marmosets. to extend genetic engineering approaches to widespread biomedical research fields, efficient prolonged in vitro culturing of embryo development is necessary. we aimed to evaluate the effects of the size of the zona pellucida opening on promoting the hatching process in the marmoset embryo. piezo-microdri ... | 2013 | 24000827 |
| motor planning for vocal production in common marmosets. | the vocal motor plan is one of the most fundamental and poorly understood elements of primate vocal production. here we tested whether a single vocal motor plan comprises the full length of a vocalization. we hypothesized that if a single motor plan was determined at vocal onset, the acoustic features early in the call should be predictive of the subsequent call structure. analyses were performed on two classes of features in marmoset phee calls: continuous and discrete. we first generated corre ... | 2009 | 23997242 |
| efficient in vivo depletion of cd8(+) t lymphocytes in common marmosets by novel cd8 monoclonal antibody administration. | in order to directly demonstrate the roles of cd8(+) t lymphocytes in non-human primates, in vivo depletion of the cd8(+) t cells by administration of a cd8-specific monoclonal antibody (mab) is one of the crucial techniques. recently, the common marmoset (callithrix jacchus), which is classified as a new world monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, parkinson's disease and a number of infectious diseases. here we show ... | 2013 | 23969290 |
| cholinergic manipulation of motor disability and l-dopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated common marmosets. | anti-cholinergic drugs are used in the treatment of parkinson’s disease (pd) and they can improve motor disability in some patients and may alter the expression of dyskinesia. we report the effects of anticholinergic and pro-cholinergic agents administered alone and combined with l-dopa, on motor function in 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (mptp)-treated common marmosets. administration of atropine to mptp-treated marmosets, not previously exposed to l-dopa, improved motor disabilit ... | 2014 | 23959162 |
| spontaneous rhabdomyosarcoma in a common marmoset ( callithrix jacchus ). | the common marmoset (callithrix jacchus) is now widely used in various research fields, including toxicology. however, information about the background pathology of this species is scarce. here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. a 44-month-old male common marmoset was euthanized due to bilateral hind limb paralysis. at necropsy, a 2×2×5-cm intramuscular mass was observed in the lower right back. histologically, the mass was mainly composed of ... | 2013 | 23914060 |
| overview of models, methods, and reagents developed for translational autoimmunity research in the common marmoset (callithrix jacchus). | the common marmoset (callithrix jacchus) is a small-bodied neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (aimid), such as rheumatoid arthritis (ra) and multiple sclerosis (ms). the animal model for ms established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificit ... | 2013 | 23903050 |
| experimental cross-species infection of common marmosets by titi monkey adenovirus. | adenoviruses are dna viruses that infect a number of vertebrate hosts and are associated with both sporadic and epidemic disease in humans. we previously identified a novel adenovirus, titi monkey adenovirus (tmadv), as the cause of a fulminant pneumonia outbreak in a colony of titi monkeys (callicebus cupreus) at a national primate center in 2009. serological evidence of infection by tmadv was also found in a human researcher at the facility and household family member, raising concerns for pot ... | 2013 | 23894316 |
| detection of calprotectin and apoptotic activity in the colon of marmosets with chronic diarrhea. | the common marmoset (callithrix jacchus) is used as a non-human primate laboratory animal. marmoset wasting syndrome (mws) is a disease endemic to captive colonies, and the pathogenesis is unclear. in the present study, marmosets with chronic bloody high-viscosity diarrhea, which is a contributing factor to mws, were evaluated, and inflammation in the colon was found. calprotectin is a surrogate marker of intestinal inflammation and induces apoptosis. marmosets with chronic diarrhea exhibited hi ... | 2013 | 23884022 |
| conjunctival flora, schirmer's tear test, intraocular pressure, and conjunctival cytology in neotropical primates from salvador, brazil. | this study aimed to establish reference values for selected ophthalmic diagnostic tests in healthy neotropical primates from salvador, brazil. | 2013 | 23879249 |
| airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (callithrix jacchus). | animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics for respiratory diseases. the aim of the present study was to examine lung-function parameters in marmoset monkeys (callithrix jacchus) that can be used to detect pharmacologically or provocation-induced ahr (airway hyper-responsiveness). therefore a custom-made lung-function device that allows application of defined aerosol doses during measurement was developed. it was hypothesiz ... | 2014 | 23879175 |
| characterization of secretagogin-immunoreactive amacrine cells in marmoset retina. | the retina contains at least 30 different types of amacrine cells but not many are well characterized. in the present study the calcium-binding protein secretagogin was localized in a population of regular and displaced amacrine cells in the retina of the common marmoset callithrix jacchus. irrespective of their soma location, the dendrites of secretagogin amacrine cells occupy strata 2, 3, and 4 of the inner plexiform layer, between the two bands formed by cholinergic amacrine cells. segretagog ... | 2014 | 23852983 |
| expression of taste signal transduction molecules in the caecum of common marmosets. | the extraoral presence of taste signal transduction proteins has recently been reported in rodents and humans. here, we report for the first time the presence of these signal transduction proteins in the caecum of a non-human primate, the common marmoset. quantitative rt-pcr data on the gene expression of taste signal transduction molecules (gustducin and trpm5) in common marmosets suggested high expression in the caecum, which was not observed in other non-human primates. immunohistochemical an ... | 2013 | 23843216 |
| induction of experimental autoimmune encephalomyelitis with recombinant human myelin oligodendrocyte glycoprotein in incomplete freund's adjuvant in three non-human primate species. | the experimental autoimmune encephalitis (eae) model is used for preclinical research into the pathogenesis of multiple sclerosis (ms), mostly in inbred, specific pathogen free (spf)-raised laboratory mice. however, the naive state of the laboratory mouse immune system is considered a major hurdle in the translation of principles from the eae model to the ms patient. non-human primates (nhp) have an immune system harboring t- and b-cell memory against environmental antigens, similar as in humans ... | 2013 | 23821341 |
| lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates. | remote regions such as the thalamus undergo secondary degeneration after cerebral ischemia. in rodents, the pathology in the thalamus is characterized by a robust inflammatory reaction, β-amyloid (aβ) accumulation and calcification. here we studied whether nonhuman primates subjected to middle cerebral artery occlusion (mcao) display a similar pathology. common marmosets (n=4) were subjected to transient mcao for 3 h. two sham-operated animals served as controls. all animals underwent mri examin ... | 2013 | 23810737 |
| differential cadherin expression in the developing postnatal telencephalon of a new world monkey. | cadherins are cell adhesion molecules widely expressed in the nervous system, where they play various roles in neural patterning, nuclei formation, axon guidance, and synapse formation and function. although many published articles have reported on cadherin expression in rodents and ferrets, there are limited data on their expression in primate brains. in this study, in situ hybridization analysis was performed for 10 cadherins [nine classic cadherins (cdh4, -6, -7, -8, -9, -10, -11, -12, and -2 ... | 2013 | 23784870 |
| the primate eae model points at ebv-infected b cells as a preferential therapy target in multiple sclerosis. | the remarkable clinical efficacy of anti-cd20 monoclonal antibodies (mab) in relapsing-remitting multiple sclerosis points at the critical involvement of b cells in the disease. however, the exact pathogenic contribution of b cells is poorly understood. in this publication we review new data on the role of cd20+ b cells in a unique experimental autoimmune encephalomyelitis (eae) model in common marmosets (callithrix jacchus), a small-bodied neotropical primate. we will also discuss the relevance ... | 2013 | 23781220 |
| the behavioral context of visual displays in common marmosets (callithrix jacchus). | communication is important in social species, and may occur with the use of visual, olfactory or auditory signals. however, visual communication may be hampered in species that are arboreal have elaborate facial coloring and live in small groups. the common marmoset fits these criteria and may have limited visual communication. nonetheless, some (contradictive) propositions concerning visual displays in the common marmoset have been made, yet quantitative data are lacking. the aim of this study ... | 2013 | 23776035 |
| perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging. | background magnetic resonance imaging (mri) can provide in vivo assessment of tissue damage, allowing evaluation of multiple sclerosis (ms) lesion evolution over time--a perspective not obtainable with postmortem histopathology. relapsing-remitting experimental autoimmune encephalomyelitis (eae) is an experimental model of ms that can be induced in the common marmoset, a small new world primate, and that causes perivenular white matter (wm) lesions similar to those observed in ms. methods brain ... | 2014 | 23773983 |
| socially adjusted synchrony in the activity profiles of common marmosets in light-dark conditions. | synchronized state of activity and rest might be attained by mechanisms of entrainment and masking. most zeitgebers not only act to entrain but also to mask circadian rhythms. although the light-dark (ld) cycle is the main zeitgeber of circadian rhythms in marmosets, social cues can act as weaker zeitgebers. evidence on the effects of social entrainment in marmosets has been collected in isolated animals or in pairs where activity is not individually recorded. to characterize the synchronization ... | 2013 | 23767997 |
| comparison of three different sedative-anaesthetic protocols (ketamine, ketamine-medetomidine and alphaxalone) in common marmosets (callithrix jacchus). | handling of common marmoset (callithrix jacchus) usually requires chemical restraint. ketamine has been associated with muscle damage in primates, while common marmosets, compared to other primates, additionally display an exceptional high sensitivity to ketamine-associated side-effects. notably, muscle twitching movements of limbs and hands, and a marked increase in salivation are observed. we investigated two alternative intramuscular (i.m.) immobilisation protocols against ketamine (50 mg/kg; ... | 2013 | 23758836 |
| ultrasound-guided non-surgical embryo collection in the common marmoset. | experimental primate embryology has been hampered by limited access to embryos. in addition to surgical techniques, the less stressful non-surgical technique of uterine flushing has been developed but has had only limitedly used in recovering pre-implantation embryos from marmoset monkeys. in this study, we introduce the use of ultrasonography during marmoset non-surgical uterine flushing to make the cannulation easier, to further reduce stress, and to ensure thorough uterine flushing. we were a ... | 2013 | 23719119 |
| differential virulence and disease progression following mycobacterium tuberculosis complex infection of the common marmoset (callithrix jacchus). | existing small-animal models of tuberculosis (tb) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. to develop a smaller primate model with pathology similar to that seen in humans, we experimentally infected the common marmoset (callithrix jacchus) with diverse strains of mycobacterium tuberculosis of various pathogenic potentials. these included recent isolates of the modern beijing lineage, the euro- ... | 2013 | 23716617 |
| robust long-term transduction of common marmoset neuromuscular tissue with raav1 and raav9. | profiles of recombinant adeno-associated virus (raav)-mediated transduction show interspecies differences for each aav serotype. robust long-term transgene expression is generally observed in rodents, whereas insufficient transduction is seen in animals with more advanced immune systems. non-human primates, including the common marmoset, could provide appropriate models for neuromuscular diseases because of their higher brain functions and physiological resemblance to humans. strategies to induc ... | 2013 | 23715217 |
| the influence of gluten on clinical and immunological status of common marmosets (callithrix jacchus). | common marmosets (callithrix jacchus) are susceptible to gastrointestinal diseases. sensitivity to nutritional elements, for example gluten, has been suggested, but a serological screening has not been performed yet. | 2013 | 23710695 |
| the role of harmonic resolvability in pitch perception in a vocal nonhuman primate, the common marmoset (callithrix jacchus). | pitch is one of the most fundamental percepts in the auditory system and can be extracted using either spectral or temporal information in an acoustic signal. although pitch perception has been extensively studied in human subjects, it is far less clear how nonhuman primates perceive pitch. we have addressed this question in a series of behavioral studies in which marmosets, a vocal nonhuman primate species, were trained to discriminate complex harmonic tones differing in either spectral (fundam ... | 2013 | 23699526 |
| an embedded four-channel receive-only rf coil array for fmri experiments of the somatosensory pathway in conscious awake marmosets. | fmri has established itself as the main research tool in neuroscience and brain cognitive research. the common marmoset (callithrix jacchus) is a non-human primate model of increasing interest in biomedical research. however, commercial mri coils for marmosets are not generally available. the present work describes the design and construction of a four-channel receive-only surface rf coil array with excellent signal-to-noise ratio (snr) specifically optimized for fmri experiments in awake marmos ... | 2013 | 23696219 |
| patterns of cortical reorganization in the adult marmoset after a cervical spinal cord injury. | in the present study, we used microelectrode recordings of multiunit responses to evaluate patterns of the reactivation of somatosensory cortex after sensory loss produced by spinal cord lesions in the common marmoset (callithrix jacchus). these new world monkeys have become a popular model in studies of cortical organization and function. primary somatosensory cortex and adjoining somatosensory areas can become extensively deactivated by lesions of somatosensory afferents as they ascend in the ... | 2013 | 23681952 |
| quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset. | the purpose of this study was to determine the protein amounts of blood-brain barrier (bbb) permeability-related transporters, receptors, and tight junction proteins in sprague dawley and wistar rats and common marmoset, and also to investigate inter-species and inter-strain differences across rodents and primates. quantification of target proteins in isolated brain capillaries was conducted by liquid chromatography-tandem mass spectrometry-based quantitative targeted absolute proteomics, with i ... | 2013 | 23650139 |
| dissecting the mechanisms of squirrel monkey (saimiri boliviensis) social learning. | although the social learning abilities of monkeys have been well documented, this research has only focused on a few species. furthermore, of those that also incorporated dissections of social learning mechanisms, the majority studied either capuchins (cebus apella) or marmosets (callithrix jacchus). to gain a broader understanding of how monkeys gain new skills, we tested squirrel monkeys (saimiri boliviensis) which have never been studied in tests of social learning mechanisms. to determine wh ... | 2013 | 23638347 |
| effects of a dopamine d1 agonist on ketamine-induced spatial working memory dysfunction in common marmosets. | it is considered that functional deficiency of the nmda receptors in the prefrontal cortex (pfc) is one of the causes of the cognitive impairment observed in schizophrenia. as non-human primates display more developed pfc than rodents, they are considered to be useful experimental animals for improving the predictive validity of models used to discover new drugs for treating cognitive dysfunction. the aim of this study was to develop a convenient model of the cognitive impairment observed in sch ... | 2013 | 23608483 |
| numerical chromosome disorders in the common marmoset (callithrix jacchus)--comparison between two captive colonies. | chromosomal analyses were performed for marmosets from two colonies - deutsches primatenzentrum (dpz) and biomedical primate research centre (bprc). chlorine-based disinfectants are used in dpz; no chemical disinfection is applied in bprc. | 2013 | 23600894 |
| the effect of habitat acoustics on common marmoset vocal signal transmission. | noisy acoustic environments present several challenges for the evolution of acoustic communication systems. among the most significant is the need to limit degradation of spectro-temporal signal structure in order to maintain communicative efficacy. this can be achieved by selecting for several potentially complementary processes. selection can act on behavioral mechanisms permitting signalers to control the timing and occurrence of signal production to avoid acoustic interference. likewise, the ... | 2013 | 23592313 |
| hand preference depends on posture in common marmosets. | postural conditions are known to affect hand use in many primate species. it remains to be examined how posture and task differences modulate, or interact with, hand use in common marmosets (callithrix jacchus). three experimental conditions were introduced to assess the occurrence of preferential hand use as a function of posture and size of aperture for the subjects to grasp and retrieve the food item bi- or unimanually: ground level condition for requiring quadrupedal posture with enough spac ... | 2013 | 23578761 |
| fmri in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia. | functional neuroimaging in animal models is essential for understanding the principles of neurovascular coupling and the physiological basis of fmri signals that are widely used to study sensory and cognitive processing in the human brain. while hemodynamic responses to sensory stimuli have been characterized in humans, animal studies are able to combine very high resolution imaging with invasive measurements and pharmacological manipulation. to date, most high-resolution studies of neurovascula ... | 2013 | 23571417 |
| spontaneous tyzzer's disease with the central nerve involvement in a newborn common marmoset. | a new-born (8-day-old) male marmoset (callithrix jacchus) was found dead in a zoo. the littermate and parents had no clinical abnormalities. by gross observations at necropsy, there were moderate to severe multiple necrotic foci in the liver and heart. histopathological examinations also revealed mild focal necrosis with neutrophilic infiltration in the cerebral cortex. by giemsa stained sections, intracytoplasmic bundles of large bacilli were observed in the hepatocytes, intestinal epithelial c ... | 2013 | 23558957 |
| development and characterization of cdna resources for the common marmoset: one of the experimental primate models. | the common marmoset is a new world monkey, which has become a valuable experimental animal for biomedical research. this study developed cdna libraries for the common marmoset from five different tissues. a total of 290 426 high-quality est sequences were obtained, where 251 587 sequences (86.5%) had homology (1e(-100)) with the refseqs of six different primate species, including human and marmoset. in parallel, 270 673 sequences (93.2%) were aligned to the human genome. when 247 090 sequences w ... | 2013 | 23543116 |
| efficient embryo transfer in the common marmoset monkey (callithrix jacchus) with a reduced transfer volume: a non-surgical approach with cryopreserved late-stage embryos. | among primates, the common marmoset is suitable for primate embryology research. its small body size, however, has delayed the technical development of efficient embryo transfer. furthermore, three factors have been determined to adversely affect the performance of marmoset embryo transfer: nonsurgical approaches, the use of cryopreserved embryos, and the use of late-stage embryos. here we performed embryo transfer under conditions that included the above three factors and using either a small ( ... | 2013 | 23536374 |