Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| characterization of two novel linear b-cell epitopes in the capsid protein of avian hepatitis e virus (hev) that are common to avian, swine, and human hevs. | antisera raised against the avian hepatitis e virus (hev) capsid protein are cross-reactive with human and swine hev capsid proteins. in this study, two monoclonal antibodies (mabs) against the avian hev capsid protein, namely, 3e8 and 1b5, were shown to cross-react with the swine hev capsid protein. the motifs involved in binding both mabs were identified and characterized using phage display biopanning, peptide synthesis, and truncated or mutated protein expression, along with indirect enzyme- ... | 2015 | 25741007 |
| neuralgic amyotrophy complicating acute hepatitis e infection: a rare association. | hepatitis e virus infection (hev) is an emerging pathogen that is under-recognised in developed countries. preceding infection manifested by acute transaminitis has been associated with neurological manifestations, predominately involving the peripheral nervous system, even in immunocompetent patients. we present a case of a 65-year-old previously fit and well caucasian man with bilateral neuralgic amyotrophy (na) and acute transaminitis. serology testing for immunoglobulin (ig) m and g establis ... | 2015 | 25739795 |
| long-term efficacy of a hepatitis e vaccine. | hepatitis e virus (hev) is a leading cause of acute hepatitis. the long-term efficacy of a hepatitis e vaccine needs to be determined. | 2015 | 25738667 |
| making hepatitis e a vaccine-preventable disease. | a hepatitis e vaccine could become a powerful new tool in the prevention and control of hepatitis e virus transmission and disease. most immediately, it can have a role in curbing outbreaks of hepatitis e in humanitarian crises. | 2015 | 25738664 |
| hepatitis e vaccine to prevent morbidity and mortality during epidemics. | recurrent, large, waterborne epidemics of hepatitis e virus (hev) occur regularly after monsoon rains contaminate water supplies in asia or during humanitarian crises in africa. these epidemics commonly affect thousands of persons, and it has a high mortality in pregnant women who become infected. although a subunit hev vaccine has been developed by chinese investigators and was found to be highly effective and safe in a large clinical trial, this vaccine is only available in china. until it is ... | 2014 | 25734166 |
| a study of viral hepatitis e infection in a tertiary care hospital in mysore, south india. | in this study, we aimed to explore the clinical and epidemiological profile of all patients with hepatitis e virus (hev) who were admitted to a tertiary care hospital in mysore, india and to further assess various factors that influence the prognosis of these patients. | 2014 | 25734105 |
| treatment with ribavirin of hepatitis e virus chronic infection in transplanted patients. | 2015 | 25733048 | |
| evaluation of an antigen-capture eia for the diagnosis of hepatitis e virus infection. | an enzyme immunoassay (eia) has been developed for hepatitis e virus (hev) antigen (hev-ag) detection and marketed in china. this study aimed to evaluate the sensitivity of the assay and assess the value of hev-ag detection in the diagnosis of hev infection in comparison with hev rna detection. using serial dilutions of a genotype 4 hev strain, significant correlation was found between the eia (s/co) and hev rna (iu/ml) concentration in the range 10(3.5) to 10(0.5) iu/ml hev rna, the pearson cor ... | 2015 | 25732029 |
| hepatitis e virus in hematopoietic stem cell donors: towards a systematic hev screening of donors? | 2015 | 25727994 | |
| a case of hepatitis e in a blood donor. | the threat of hepatitis e is being felt in blood banks in recent times. the disease is usually self-limiting, but may progress to a fulminant fatal form. we report a unique case of a hepatitis e virus (hev)-positive asymptomatic blood donor who later developed jaundice and informed the blood bank. a blood donor passed all eligibility criteria tests and donated blood. after 20 days, the blood bank was informed by the donor that he had developed vomiting and jaundice 1 day postdonation. he was inv ... | 2017 | 25722580 |
| the development of a recombinant hepatitis e vaccine hev 239. | hepatitis e virus (hev) infection is one of the main causes of acute hepatitis worldwide. a recombinant hepatitis e vaccine, hev 239, has been licensed in china for immunizing adults of 16 y old and above. the vaccine antigen contains porf2 aa 368 - 606 of the hev genotype 1 expressed in e. coli. the quality of the vaccine is controlled through a combination of biophysical, biochemical and immunochemical methods. the vaccine is well tolerated in adults. the efficacy of the hev 239 vaccine agains ... | 2015 | 25714510 |
| prevalence of hepatitis e virus in chinese blood donors. | to investigate the prevalence of hepatitis e virus (hev) antibodies and rna in voluntary blood donors, in china. | 2015 | 25710945 |
| successful treatment of hepatitis e virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. | hepatitis e virus genotype-3 (hev3) infection can cause chronic hepatitis in immunosuppressed patients and induce extra-hepatic manifestations, such as neurological symptoms, kidney injuries, and immune-mediated thrombocytopenia. very few cases of hev-induced kidney manifestations have been reported. herein, we report, for the first time, a case of de novo membranoproliferative glomerulonephritis that occurred in a kidney transplant patient who developed a chronic hev3 infection, which was succe ... | 2015 | 25708383 |
| systematic serological testing for hepatitis e virus in kidney transplant recipients. | hepatitis e virus (hev) genotype 3 is endemic in europe and hyperendemic in southern france. recent reports of a high prevalence of hev rna in blood donations and in culinary specialties from this geographical area confirmed the endemicity of hev and sources of viral transmission in this geographical area. hev causes acute and chronic hepatitis in solid organ transplant recipients. since march 2012, we have implemented systematic hev serological testing in our cohort of kidney transplant recipie ... | 2015 | 25694530 |
| mystery of hepatitis e virus: recent advances in its diagnosis and management. | mysterious aspects of the long presumed to be well-known hepatitis e virus (hev) have recently surfaced that distinguish it from other hepatotropic viruses. it is a cause of chronic hepatitis in immunosuppressed patients. it has human to human transmission through blood and mantains high seroprevalence in blood donors. hev has also been found to occur more frequently in the west in those without a history of travel to endemic countries. it has varied extrahepatic manifestations and has multiple ... | 2015 | 25692043 |
| surveillance of hepatitis e virus contamination in shellfish in china. | hepatitis e virus (hev) has been confirmed to be a zoonotic virus of worldwide distribution. hev contamination in the water environment has not been well examined in china. the objective of this study was to evaluate hev contamination in shellfish in a coastal area of china. such contamination would be significant for evaluating public health risks. | 2015 | 25689991 |
| presence of human and animal viruses in surface waters in vojvodina province of serbia. | for the first time in serbia, a small surveillance study was conducted in order to estimate the presence and frequency of occurrence of selected human [adenoviruses (hadv), noroviruses, (nov gi, nov gii) and hepatitis a virus (hav)], animal [porcine adenovirus (padv) and bovine polyomavirus (bpyv)] and zoonotic [hepatitis e virus (hev)] viruses in selected surface waters. in total, 60 surface water samples were collected in two sampling occasions at 30 locations, with each sampling time being se ... | 2015 | 25687987 |
| hepatitis e in a food handler--a rapid risk assessment to guide the public health response. | the australian capital territory health directorate was notified of a food handler with hepatitis e virus (hev) infection. to guide the public health response, a rapid risk assessment was undertaken to determine the risk of transmission of hev from the infected food handler to restaurant patrons. | 2015 | 25685598 |
| a scoping review of the evidence for public health risks of three emerging potentially zoonotic viruses: hepatitis e virus, norovirus, and rotavirus. | emerging zoonoses are defined as those newly recognized, or increasing in incidence or geographic range. hepatitis e virus (hev), norovirus (nov), and rotavirus (rv), while well known to be transmitted person-person, have also been hypothesized to be emerging zoonoses. our objective was to investigate their potential public health risks from animal reservoirs. given the diversity of evidence sources, a scoping review incorporating a mixed methods synthesis approach was used. a broad search was c ... | 2015 | 25681862 |
| xenotransplantation and hepatitis e virus. | xenotransplantation using pig cells, tissues and organs may be associated with the transmission of porcine microorganisms to the human recipient. some of these microorganisms may induce a zoonosis, that is an infectious disease induced by microorganisms transmitted from another species. with exception of the porcine endogenous retroviruses (pervs), which are integrated in the genome of all pigs, the transmission of all other microorganisms can be prevented by specified or designated pathogen-fre ... | 2015 | 25676629 |
| acute liver failure in pregnancy: causative and prognostic factors. | acute liver failure (alf) in pregnancy is often associated with a poor prognosis. in this single-center observational study we aim to study the incidence, causes, and factors affecting mortality in pregnant women with alf. | 2017 | 25672236 |
| the detection rate of enteric viruses and clostridium difficile in a waste water treatment plant effluent. | waste water treatment plant (wwtp) is considered as an important source of surface water contamination by enteric pathogens. in this study, we describe the occurrence of enteric viruses (group a rotaviruses, noroviruses, astroviruses, sapoviruses, hepatitis a virus, and hepatitis e virus) and clostridium difficile in the effluent of a wastewater treatment plant during a 1-year period. enteric viruses were simultaneously and efficiently concentrated in a single step using methacrylate monolithic ... | 2015 | 25663146 |
| hepatitis e virus infection presenting with paraesthesia. | hepatitis e virus infection is an emerging disease in developed countries. acute and chronic infection has been reported, with chronic infection being increasingly reported in immunocompromised patients. neurological disorders are an emerging manifestation of both acute and chronic hepatitis e virus infection. we report a 77-year-old female presented with paraesthesia and was found to have abnormal liver function tests. serology was found to be positive for hepatitis e virus igm, igg and rna. li ... | 2015 | 25663032 |
| [the emergence of the universal hepatitis e virus]. | 2015 | 25662036 | |
| prevalence of hepatitis a virus (hav) and hepatitis e virus (hev) in the patients presenting with acute viral hepatitis. | hepatitis a virus (hav) and hepatitis e virus (hev) are both enterically transmitted, resulting in acute viral hepatitis (avh) in developing countries. they pose major health problems in our country. this study was done to determine prevalence of hav and hev in patients presenting with avh and the co-infection of hav and hev in these patients. | 2015 | 25657123 |
| a survey on the status of hepatitis e virus infection among slaughterhouse workers in south korea. | the seroprevalence of hepatitis e virus (hev) among high-risk groups overseas is high, but studies in these groups are rare in south korea. we conducted the present study from april to november 2012 to obtain data on the seroprevalence and associated risk factors for hev among slaughterhouse workers in south korea. | 2015 | 25652711 |
| [hepatitis e virus]. | hev is a small non-enveloped rna virus that is associated to lipids in the blood of infected individuals. the genera orthohepevirus recently proposed includes the zoonotic mammals strains. the other strains of the family hepeviridae are not transmissible to humans. the diagnosis of hev infection should be considered in any patient with serum alt elevation. the diagnosis of hev infection in immunocompetent patients relies on detecting igm antibodies in the blood. the diagnosis of hev infection in ... | 2015 | 25650296 |
| variability of hepatitis e serologic assays in a pediatric liver transplant recipient: challenges to diagnosing hepatitis e virus infection in the united states. | hepatitis e virus (hev) is an emerging cause of viral hepatitis among immunocompromised individuals in developed countries. yet the diagnosis of hev infection in the united states remains challenging, because of the variable sensitivity and specificity of currently available tests, and the lack of a us food and drug administration-approved test. we report a case of multiple discordant hev serology results in a pediatric liver transplant recipient with idiopathic hepatitis, and review the challen ... | 2015 | 25648626 |
| [treatment of hepatitis e virus infection]. | the reduction of immunosuppressive therapy is the first-line therapeutic option in transplant-patients with chronic hepatitis e virus infection. pegylated-interferon has been used for treating hepatitis e virus infection. ribavirin alone is the treatment of choice of hepatitis e virus infection. ribavirin is efficient for treating chronic hepatitis e in transplant patients, hiv patients, and hematology patients receiving or not chemotherapy. ribavirin should be given to patients presenting hepat ... | 2015 | 25639626 |
| [epidemiology of hepatitis e: a (re) emerging disease?]. | hepatitis e virus (vhe) is a rna, non-enveloped, enterically transmitted virus. vhe is present all around the world, with different distribution of its genotypes. vhe of genotypes 1 and 2 predominate in asia, africa and in mexico, responsible for outbreaks transmitted through contaminated water, with an increased mortality in pregnant women. genotype 3 vhe are globally distributed, with an animal reservoir (swine mainly) endemic in high-income countries. they are transmitted by the ingestion of ... | 2015 | 25639625 |
| construction and characterization of an infectious cdna clone of rat hepatitis e virus. | rat hepatitis e virus (hev) is related to human hev and has been detected in wild rats worldwide. here, the complete genome of rat hev strain r63/deu/2009 was cloned downstream of the t7 rna polymerase promoter and capped genomic rna generated by in vitro transcription was injected into nude rats. rat hev rna could be detected in serum and faeces of rats injected intrahepatically, but not in those injected intravenously. rat hev rna-positive faecal suspension was intravenously inoculated into nu ... | 2015 | 25634930 |
| regeneration of recombinant antigen microarrays for the automated monitoring of antibodies against zoonotic pathogens in swine sera. | the ability to regenerate immobilized proteins like recombinant antigens (rags) on surfaces is an unsolved problem for flow-based immunoassays on microarray analysis systems. the regeneration on microarray chip surfaces is achieved by changing the protein structures and desorption of antibodies. afterwards, reactivation of immobilized protein antigens is necessary for reconstitution processes. any backfolding should be managed in a way that antibodies are able to detect the protein antigens in t ... | 2015 | 25625908 |
| experimental infection of z:zcla mongolian gerbils with human hepatitis e virus. | to investigate whether z:zcla mongolian gerbils are readily susceptible to infection by human hepatitis e virus (hev). | 2015 | 25624719 |
| seroprevalence and molecular characteristics of hepatitis e virus in household-raised pig population in the philippines. | hepatitis e virus (hev) infection is a significant public health concern in asia, and swine is an important source of sporadic hev infection in human. however, no epidemiological data are available regarding hev infection among the swine or human population in the philippines. to assess the hev infection status among pigs in rural areas, we investigated the molecular characteristics and seroprevalence of hev among household-raised pigs in san jose, tarlac province, the philippines. | 2015 | 25622684 |
| hepatitis e virus enters liver cells through a dynamin-2, clathrin and membrane cholesterol-dependent pathway. | the hepatitis e virus (hev) causes large outbreaks and sporadic cases of acute viral hepatitis in developing countries. in the developed world, hev occurrence has increased as a result of zoonotic transmission from swine. the cellular aspects of hev infection, especially the determinants of entry, are poorly understood. in the absence of a robust in vitro culture system for hev, it is not possible to produce high titre infectious virus that can be labeled for tracking its internalization. we hav ... | 2015 | 25615268 |
| pregnancy serum facilitates hepatitis e virus replication in vitro. | hepatitis e virus (hev) infection causes high mortality in pregnant women. however, the pathogenic mechanisms of hev infection in pregnant women remain unknown. in this study, the roles of pregnancy serum in hev infection were investigated using an efficient cell culture system. hev infection was exacerbated by supplementing with pregnancy serum, especially theat in third trimester of pregnancy. oestrogen receptors (er-α and er-β) were activated in cells supplemented with pregnancy serum and wer ... | 2015 | 25614592 |
| the lysine residues within the human ribosomal protein s17 sequence naturally inserted into the viral nonstructural protein of a unique strain of hepatitis e virus are important for enhanced virus replication. | hepatitis e virus (hev) is an important but extremely understudied human pathogen. due largely to the lack of an efficient cell culture system for hev, the molecular mechanisms of hev replication and pathogenesis are poorly understood. recently, a unique genotype 3 strain of hev recovered from a chronically infected patient was adapted for growth in hepg2c3a human hepatoma cells. the adaptation of the kernow c-1 p6 hev to propagate in hepg2c3a cells selected for a rare virus recombinant that con ... | 2015 | 25609799 |
| [hepatitis e virus: opinions of the working group of the federal ministry of health blood]. | 2015 | 25608627 | |
| hev infection in two referral centers in spain: epidemiology and clinical outcomes. | hepatitis e virus (hev) is one of the major causes of icteric hepatitis worldwide. in industrialized countries it is considered an emerging disease, as a growing number of autochthonous cases have been reported in recent years. occasional extrahepatic manifestations have been described in the setting of hev infection. | 2015 | 25600611 |
| the intergenic-junction variant (genotype 2 isolate) of hepatitis e virus restores the crex 'stem-loop' structural integrity, essential for viral life cycle. | among the known human hev strains (genotypes 1, 2, 3 and 4), the genotype 2 mexican isolate has two 'double-base' substitutions (5'u5100g5101→cu/3'c5117u5118→gg) flanking the conserved cis-reactive element (cre) in the intergenic-junction sequences. while the 'c5100u5101' natural mutations in the upstream orf1 coding region replace 'alanine' for the conserved 'valine', the 'g5117g5118' doublet resides in the downstream non-coding/promoter region of orf3 gene. though a stable 'stem-loop' structur ... | 2015 | 25597766 |
| construction of an infectious cdna clone of genotype 1 avian hepatitis e virus: characterization of its pathogenicity in broiler breeders and demonstration of its utility in studying the role of the hypervariable region in virus replication. | a full-length infectious cdna clone of the genotype 1 korean avian hepatitis e virus (avian hev) (pt11-ahev-k) was constructed and its infectivity and pathogenicity were investigated in leghorn male hepatoma (lmh) chicken cells and broiler breeders. we demonstrated that capped rna transcripts from the pt11-ahev-k clone were translation competent when transfected into lmh cells and infectious when injected intrahepatically into the livers of chickens. gross and microscopic pathological lesions un ... | 2015 | 25593160 |
| zoonotic origin of hepatitis e. | the concept of zoonotic viral hepatitis e has emerged a few years ago following the discovery of animal strains of hepatitis e virus (hev), closely related to human hev, in countries where sporadic cases of hepatitis e were autochthonous. recent advances in the identification of animal reservoirs of hev have confirmed that strains circulating in domestic and wild pigs are genetically related to strains identified in indigenous human cases. the demonstration of hev contamination in the food chain ... | 2015 | 25588602 |
| constant hepatitis e virus (hev) circulation in wild boar and red deer in spain: an increasing concern source of hev zoonotic transmission. | hepatitis e is a viral zoonosis that affects multiple hosts. the complete dynamics of infection in wildlife are still unknown, but the previous fact facilitates the maintenance and circulation of the virus, posing a risk to human health in the case of meat consumption from susceptible animals. in spain, it has been shown how domestic pigs, cattle and wildlife (i.e. wild boar and red deer) clearly interact in hunting farms, generating a complex epidemiological situation in terms of interspecies p ... | 2016 | 25571944 |
| hepatitis e virus in young pigs in finland and characterization of the isolated partial genomic sequences of genotype 3 hev. | hepatitis e virus (hev) infections occur in swine worldwide. the porcine infection is usually subclinical, but hev genotypes 3 and 4 are zoonotic agents that cause sporadic, indigenous human cases of hepatitis e. the aims of this study were to investigate the occurrence and dynamics of hev infections in young pigs by analyzing a total of 273 fecal samples collected from six farrowing farms, to genetically characterize the hev isolates obtained, and to examine the phylogenetic relationships of he ... | 2015 | 25568927 |
| hepatitis e virus: do locally acquired infections in australia necessitate laboratory testing in acute hepatitis patients with no overseas travel history? | hepatitis e virus (hev) is emerging as a global public health threat. water-borne hev outbreaks are common in developing countries and are associated with genotypes 1 and 2. in industrialised countries, sporadic cases of zoonotic transmission associated with genotypes 3 and 4 are increasingly being reported. transfusion- and transplantation-transmitted hev have been documented, although ingestion of contaminated food is thought to be the major transmission route. severe disease is possible and c ... | 2015 | 25560836 |
| preliminary molecular epidemiological investigation of hepatitis e virus sequences from québec, canada. | our study objective was to describe the canadian hepatitis e virus (hev) sequences currently cataloged in genbank from three populations: commercially raised pigs, retail pork, and locally acquired hepatitis e cases, and to interpret the molecular evidence they provide. we searched the genbank for any/all canadian hev sequences from these populations, and identified highly similar matches using the basic local alignment search tool (blast) algorithm, studying sequences of the partial orf2 gene. ... | 2015 | 25555901 |
| management of viral hepatitis in liver transplant recipients. | recurrence of viral hepatitis after liver transplantation (lt) can progress to graft failure and lead to a decrease in long-term survival. recently, there have been remarkable improvement in the treatment of chronic hepatitis b (chb) using potent antiviral agents. combination of hepatitis b immunoglobulin and potent antiviral therapy has brought marked advances in the management of chb for liver transplant recipients. post-transplant antiviral therapy for hepatitis c virus infection is generally ... | 2014 | 25548738 |
| frequent hepatitis e in the netherlands without traveling or immunosuppression. | in several western countries, silent endemic hepatitis e virus (hev) infection is common among blood donors. immunocompromised persons may develop chronic hepatitis e, but the relevance of endemic hev for immunocompetent persons remains largely unknown. we investigated the immune status and travel history in cases of hepatitis e in the netherlands. | 2015 | 25542468 |
| genome-wide comparisons of phylogenetic similarities between partial genomic regions and the full-length genome in hepatitis e virus genotyping. | besides the complete genome, different partial genomic sequences of hepatitis e virus (hev) have been used in genotyping studies, making it difficult to compare the results based on them. no commonly agreed partial region for hev genotyping has been determined. in this study, we used a statistical method to evaluate the phylogenetic performance of each partial genomic sequence from a genome wide, by comparisons of evolutionary distances between genomic regions and the full-length genomes of 101 ... | 2014 | 25542033 |
| a valuable antigen detection method for diagnosis of acute hepatitis e. | hepatitis e virus (hev) is a serious public health problem. the commonly used tests that are specific for current hev infection diagnosis include the detection of anti-hev igm and hev rna. here, we report an improved enzyme-linked immunosorbent assay (elisa) method for hev antigen detection with a linear range equivalent to 6.3 × 10(3) to 9.2 × 10(5) rna copies per ml. the monoclonal antibody (mab) 12f12, a high-ability mab that binds hev virus, was selected as the capture antibody from a panel ... | 2015 | 25540394 |
| no transmission of hepatitis e virus in pigs fed diets containing commercial spray-dried porcine plasma: a retrospective study of samples from several swine trials. | hepatitis e virus (hev) has been reported in the human population and pigs are a recognized reservoir for hev and a possible source of hev transmission to humans. spray-dried porcine plasma (sdpp) is an ingredient commonly used in feed for pigs around the world. even though processing conditions used to produce sdpp should be adequate to inactivate hev, it was of interest to analyze commercial sdpp samples for presence of genome and antibodies (ab) against hev and to retrospectively analyze seru ... | 2014 | 25539662 |
| acute hepatitis e virus infection and association with a subacute thyroiditis. | 2014 | 25536654 | |
| erratum to: evidence of mapk-jnk1/2 activation by hepatitis e virus orf3 protein in cultured hepatoma cells. | 2016 | 25535116 | |
| high prevalence of antibodies against hepatitis e virus in hiv-infected patients with unexplained liver disease. | to look for evidence of hepatitis e virus (hev) exposure in hiv-infected patients with unexplained elevations of liver stiffness (ls). | 2015 | 25533742 |
| seroprevalence and risk factors associated with hepatitis e virus infection in three species of pet birds in northwest china. | hepatitis e virus (hev), the causative agent of hepatitis e, has been reported in a wide variety of animals, including birds, but little is known of hev infection in pet birds in northwest china. the objective of the present investigation was to examine hev seroprevalence in three species of pet birds, namely, eurasian siskin, oriental skylark, and black-tailed grosbeak from gansu. serum samples collected from 685 pet birds from august 2011 to september 2012 were examined independently for the p ... | 2014 | 25530995 |
| in silico and in vitro interrogation of a widely used hev rt-qpcr assay for detection of the species orthohepevirus a. | hepatitis e virus (hev) infection is a public health concern worldwide, associated with waterborne outbreaks in developing countries and reported as an emerging zoonotic infection in high-income countries. a recent consensus proposal classified the isolates from human, swine, wild boar, deer, mongoose, rabbit and camel in seven genotypes within the species orthohepevirus a. in this report a popular hev rt-qpcr assay was assessed for the detection of the species orthohepevirus a. in silico analys ... | 2015 | 25528997 |
| in silico and in vitro interrogation of a widely used hev rt-qpcr assay for detection of the species orthohepevirus a. | hepatitis e virus (hev) infection is a public health concern worldwide, associated with waterborne outbreaks in developing countries and reported as an emerging zoonotic infection in high-income countries. a recent consensus proposal classified the isolates from human, swine, wild boar, deer, mongoose, rabbit and camel in seven genotypes within the species orthohepevirus a. in this report a popular hev rt-qpcr assay was assessed for the detection of the species orthohepevirus a. in silico analys ... | 2015 | 25528997 |
| hepatitis e in developed countries: current status and future perspectives. | hepatitis e virus (hev) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. recent studies have shown that hev causes acute and chronic infection in developed countries. in these geographical settings, hev is primarily a porcine zoonosis caused by genotypes 3 (hev3) and 4 (hev4). the clinical phenotype of hepatitis e continues to emerge, and recent data show that hev is associated with a range of neurological syndromes including gu ... | 2014 | 25517900 |
| epidemiology and associated risk factors of hepatitis e virus infection in plateau state, nigeria. | a cross-sectional study in nigeria was undertaken to determine the epidemiology, seroprevalence, and associated risk factors, of hepatitis e virus (hev). a total of 462 subjects were used for the study, categorized into four groups: apparently healthy persons, pregnant women, hiv positive subjects, and animal handlers. information was obtained from subjects using interviewer-administered questionnaire. blood samples were collected and analyzed for hev antibodies (igg and igm) using enzyme-linked ... | 2014 | 25512696 |
| renal transplantation in 2014: renal transplantation-reducing risk and improving outcome. | several studies published in 2014 might facilitate improvements in the treatment and long-term care of renal transplant recipients. the potential risks of living kidney donation, the efficacy and safety of alemtuzumab-based induction therapy, and the treatment of chronic hepatitis e virus infection have been addressed. | 2015 | 25511759 |
| [hepatitis e virus infection in patients with clinical diagnosis of viral hepatitis in colombia]. | hepatitis e virus (hev) is an emergent virus of global importance; it is the etiological agent of sporadic cases and outbreaks of hepatitis. the epidemiology of this infection in colombia is unknown. | 2014 | 25504123 |
| first report of chronic hepatitis e in renal transplant recipients in portugal. | hepatitis e virus (hev) infection can be responsible for chronic hepatitis in immunocompromised patients, and can rapidly evolve into fibrosis and/or hepatic cirrhosis. we present two cases of chronic hepatitis e, emphasizing the need to be aware of this entity as a growing etiology of hepatitis in transplant and immunocompromised patients. | 2014 | 25500665 |
| establishment of hepatitis e virus infection-permissive and -non-permissive human hepatoma plc/prf/5 subclones. | plc/prf/5 cells show limited permissiveness, meaning that almost all subclones are permissive; however, some subclones do not exhibit permissiveness for hepatitis e virus (hev) infection. in this study, the single-cell cloning of plc/prf/5 was performed and heterogeneous subclones characterized. notably, the efficiency of intracellular virus replication did not correlate with the permissiveness for hev infection. however, as well as binding permissive subclones, virus-like particles bound non-pe ... | 2015 | 25495578 |
| [analysis of epidemiologic and etiology of hepatitis e in hangzhou, 2004-2011]. | to comprehend the epidemiologic of hepatitis e and genetic characteristics of hepatitis e virus (hev) in hangzhou from 2004 to 2011. | 2014 | 25492286 |
| impact of hepatitis e virus seropositivity on chronic liver disease in cancer patients with hepatitis c virus infection. | immunocompromised patients can develop chronic hepatitis e virus (hev) infection and progress to cirrhosis. hepatitis c virus (hcv)-infected cancer patients who have received chemotherapeutic agents experience accelerated liver fibrosis progression. our aim was to investigate the prevalence and impact of hev seropositivity on liver-related outcomes in hcv-infected cancer patients. | 2015 | 25488194 |
| inhibition of hepatitis e virus replication by proteasome inhibitor is nonspecific. | the ubiquitin proteasome system plays important role in virus infection. a previous study showed that the proteasome inhibitor mg132 could potentially affect hepatitis e virus (hev) replication. in this study, we found that mg132 could inhibit hev and hepatitis c virus (hcv) replication-related luciferase activity in subgenomic models. furthermore, treatment with mg132 in a hev infectious model resulted in a dramatic reduction in the intracellular level of hev rna. surprisingly, mg132 concurrent ... | 2015 | 25476751 |
| detection of hepatitis e virus in pork liver sausages. | hepatitis e infection is regarded as an emerging public-health concern. the disease is normally self-limiting (mortality rate 1%), but chronic infections have recently been observed in transplanted patients. the etiological agent hev is a small rna virus infecting both humans and animals. in humans, the disease may be food-borne and pig is a main reservoir for zoonotic strains. in the present study, we evaluated the presence of hev and swine fecal cross-contamination in pork liver sausages sold ... | 2015 | 25462920 |
| survival of porcine teschovirus as a surrogate virus on pork chops during storage at 2°c. | due to the lack of an efficient cultivation system, little is known about the stability and inactivation of hepatitis e virus (hev). in addition, there is a lack of information on which cultivable virus(es) are suitable as model or surrogate viruses for hev. murine norovirus (mnv) and f-rna coliphage ms2 are potential surrogates and f-rna coliphages are a potential indicator for enteric viruses. however, the numbers of f-rna coliphages excreted by swine are relatively low. in contrast, porcine t ... | 2015 | 25461604 |
| hepatitis e virus and coliphages in waters proximal to swine concentrated animal feeding operations. | north carolina is the second leading state in pork production in the united states, with over 10 million swine. swine manure in nc is typically collected and stored in open-pit lagoons before the liquid waste is sprayed onto agricultural fields for disposal. components of this waste may be able to impact surface water quality with the potential for human exposure. this study examined viruses of public health concern in creeks adjacent to swine concentrated animal feeding operation (cafo) spray f ... | 2015 | 25461050 |
| toll like receptors in self-recovering hepatitis e patients with or without pregnancy. | hepatitis e virus (hev) causes high mortality among pregnant women. pathogenesis of hev, especially during pregnancy, is poorly understood. our aim was to assess the role of toll-like-receptors (tlrs) in hepatitis e patients with pregnancy (antenatal care, anc) or without pregnancy (non-anc). the patient categories included acute-phase, non-anc (n=46) and anc patients (2nd/3rd trimesters, n=13) and non-anc patients (n=31) during convalescence. controls included apparently healthy non-anc (n=30) ... | 2014 | 25454620 |
| absence of occult hepatitis e virus infection among hiv immunosuppressed patients. | 2015 | 25453620 | |
| high hepatitis e virus seroprevalence with absence of chronic infection in hiv-infected patients. | the seroprevalence of the hepatitis e virus (hev) and its chronicity rate in the hiv-infected population has not been well established. as a result, the magnitude of this emerging disease in this population cannot be established. | 2015 | 25452042 |
| hepatitis e as a cause of acute jaundice syndrome in northern uganda, 2010-2012. | hepatitis e virus (hev) is a common cause of acute viral hepatitis in developing countries; however, its contribution to acute jaundice syndrome is not well-described. a large outbreak of hepatitis e occurred in northern uganda from 2007 to 2009. in response to this outbreak, acute jaundice syndrome surveillance was established in 10 district healthcare facilities to determine the proportion of cases attributable to hepatitis e. of 347 acute jaundice syndrome cases reported, the majority (42%) h ... | 2015 | 25448237 |
| evidence of hepatitis e infection in swine and humans in the east region of romania. | swine hepatitis e virus (hev) is considered to be a new zoonotic agent due to its close genomic resemblance to the human hev. the aim of this study was to determine human hev seroprevalence in eastern romania and to characterize circulating swine hev sequences. | 2014 | 25447729 |
| oral immunization with recombinant hepatitis e virus antigen displayed on the lactococcus lactis surface enhances orf2-specific mucosal and systemic immune responses in mice. | hepatitis e virus (hev) as a recognized zoonotic pathogen has posed global burden on public health, which is exacerbated by lack of efficient vaccine. in this study, we constructed a recombinant (inaq-orf2 gene fusion) lactococcus lactis (l. lactis) strain nz3900 that expresses and displays the hepatitis e virus antigen orf2 utilizing an ice uncleation protein-based anchor system. after oral vaccination of balb/c mice, significantly higher levels of orf2-specific mucosal iga and serum igg were d ... | 2015 | 25445956 |
| seroepidemiology and genetic characterization of hepatitis e virus in western yunnan province. | to investigate the seroepidemiology and genetic characterization of hepatitis e virus (hev) in western yunnan province. | 2014 | 25441993 |
| seroepidemiology of hepatitis e virus infection in mennonites in mexico. | the seroepidemiology of hepatitis e virus (hev) infection in mennonites has not been studied. we aimed to determine the seroprevalence of anti-hev igg antibodies in mennonites in durango, mexico, and to compare it with the seroprevalence in general population in rural durango. the socio-demographic, clinical and behavioral characteristics of mennonites associated with hev seropositivity were also investigated. | 2015 | 25436027 |
| natural and experimental hepatitis e virus genotype 3-infection in european wild boar is transmissible to domestic pigs. | hepatitis e virus (hev) is the causative agent of acute hepatitis e in humans in developing countries, but sporadic and autochthonous cases do also occur in industrialised countries. in europe, food-borne zoonotic transmission of genotype 3 (gt3) has been associated with domestic pig and wild boar. however, little is known about the course of hev infection in european wild boar and their role in hev transmission to domestic pigs. to investigate the transmissibility and pathogenesis of wild boar- ... | 2014 | 25421429 |
| ferret hepatitis e virus infection in japan. | we examined 85 fecal samples from pet ferrets in 10 animal hospitals in japan for the detection of ferret hepatitis e virus (hev) rna. we found that 6 (7.1%) of the samples were positive for ferret hev rna. phylogenetic analysis based on the partial orf1 indicated that these ferret hev strains were clearly separated from the netherlands strains and were divided into 2 distinct clusters. these results suggest that ferret hev is genetically diverse, and since ferrets are not indigenous to japan, f ... | 2015 | 25420653 |
| hepatitis e virus genotype 4 in yak, northwestern china. | 2014 | 25419958 | |
| molecular detection of hepatitis e virus (hev) in liver biopsies after liver transplantation. | we aimed to determine the rate of hepatitis e virus (hev) infection, a recently increasingly recognized disease in the western world, in liver transplant patients by direct molecular testing of liver tissue. a rt-pcr assay was designed for detecting the hev open reading frame (orf) 2/3 gene region in formalin-fixed, paraffin-embedded tissues, and applied to all liver biopsies (n=683) taken 4 weeks or later from all patients (n=282) after liver transplantation of two large academic centers. hev-r ... | 2015 | 25412844 |
| prevalence of hepatitis e virus in slaughter-age pigs in scotland. | the prevalence of anti-hev isotype-specific antibodies and viraemia were investigated in serum samples collected from slaughter-age pigs (aged 22-24 weeks) from 23 farms in scotland. of 176 serum samples tested, 29·0% (n = 51) were anti-hev igg positive, 36·9% (n = 65) anti-hev iga positive and 29·0% (n = 51) anti-hev igm positive. overall seroprevalence (anti-hev igg+ and/or iga+ and/or igm+) was 61·4% (n = 108). hev rna was detected in 72/162 serum samples (44·4%). partial sequence of orf2 (98 ... | 2015 | 25410494 |
| hepatitis e virus in sylvatic and captive wild boar from portugal. | hepatitis e virus (hev) is a zoonotic agent today considered a major public health issue in industrialized countries. hev strains belonging to zoonotic genotype 3 are widely present in swine, being today considered important reservoirs for human disease. unlike in swine, only scarce data are available on the circulation of hev in wild boar. this study describes the detection and molecular characterization of hev in livers from sylvatic wild boar hunted in portugal and destined for consumption. a ... | 2016 | 25405272 |
| seroprevalence of hepatitis e virus (hev) and detection of hev rna with a transcription-mediated amplification assay in blood donors from catalonia (spain). | hepatitis e virus (hev) is an emerging threat to the safety of blood transfusion. the aim of this study was to determine hev immunoglobulin (ig)g and rna prevalence in catalan blood donors. | 2015 | 25403913 |
| risk factors for hepatitis e virus infection and disease. | hepatitis e, caused by hepatitis e virus, is a disease of global significance, causing 20 million infections each year. genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. in genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregnant women being the most likely to experience severe disease. in genotype 3 and 4 endemic areas, most infections and illness occur in those of age 40-60 years, with males representi ... | 2015 | 25399510 |
| new foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis e. | autochthonous hepatitis e has been observed with growing incidence in industrialized countries. hepatitis e virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. however, in individual cases, hepatitis e may lead to life-threatening acute liver failure. in this report, we describe a case of acute liver injury caused by an autochthonous hepatitis e that resolved under steroid treatment. to our knowledge, this is the first case report describing supportive ... | 2014 | 25398314 |
| acute fulminant hepatitis e virus genotype 3e infection: description of the first case in europe. | 2015 | 25390687 | |
| rna transcripts of full-length cdna clones of rabbit hepatitis e virus are infectious in rabbits. | hepatitis e virus (hev), the causative agent of hepatitis e, is a single-stranded positive-sense rna virus belonging to the family hepeviridae. at least four genotypes of the family infect humans: genotypes 1 and 2 are transmitted to humans through contaminated water, while genotypes 3 and 4 are zoonotic and have animal reservoirs. a novel strain of hev recently identified in rabbits is a distant member of genotype 3, and thus poses a potential risk of zoonotic transmission to humans. the object ... | 2014 | 25381057 |
| complete genome sequence of a rat hepatitis e virus strain isolated in the united states. | hepatitis e virus is a common cause of acute hepatitis in humans. related viruses have been isolated from multiple animal species, including rats, but their impact on human health is unclear. we present the first full-length genome sequence of a rat hepatitis e virus strain isolated in the united states (la-b350). | 2014 | 25377700 |
| prediction of interactions between viral and host proteins using supervised machine learning methods. | viral-host protein-protein interaction plays a vital role in pathogenesis, since it defines viral infection of the host and regulation of the host proteins. identification of key viral-host protein-protein interactions (ppis) has great implication for therapeutics. | 2014 | 25375323 |
| acute pancreatitis complicating acute hepatitis e virus infection: a case report and review. | acute pancreatitis complicating fulminant viral hepatitis has been well recognized; however, acute pancreatitis occurring in nonfulminant hepatitis is very rare. the case presented describes moderate pancreatitis in a young male, manifesting during the course of nonfulminant acute hepatitis e infection. the diagnosis of acute viral hepatitis e was confirmed by serology and reverse transcriptase polymerase chain reaction (rt-pcr) to demonstrate hepatitis e virus (hev) rna in both stool and serum. ... | 2013 | 25374721 |
| codon-optimized expression and purification of truncated orf2 protein of hepatitis e virus in escherichia coli. | hepatitis e virus (hev) is a causative agent of acute hepatitis among people of different age groups and has high mortality rate of up to 30% among pregnant women. therefore, primary prevention of hev infection is essential. | 2014 | 25368796 |
| analysis of hepatitis e virus-like sequence in chimpanzee. | 2014 | 25368657 | |
| clinical & immunological profile of newly diagnosed patients with youth onset diabetes mellitus. | there has been a rise in the incidence of diabetes mellitus in the younger population of india. there are limited data available on the immunological profile of youth onset diabetes mellitus (dm) especially in type 2. therefore, this study was undertaken to evaluate the clinical and immunological profile of youth onset dm in north india. | 2014 | 25366202 |
| epidemiology of hepatitis e virus in china: results from the third national viral hepatitis prevalence survey, 2005-2006. | in china, hepatitis e virus (hev) is prevalent and causes disease, but its epidemiological profile is not well understood. we used a commercial enzyme-linked immunosorbent assay to detect total antibodies to hepatitis e virus in 15,862 serum samples collected during the third national viral hepatitis prevalence survey. the results were analyzed to calculate estimates of hev seroprevalence and to examine the effects of some putative risk factors. the seroprevalence of hev in the general chinese p ... | 2014 | 25360522 |
| hepatitis e virus and implications for blood supply safety, australia. | 2014 | 25341023 | |
| hepatitis e virus infections in blood donors, france. | we screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from france that had been processed with solvent-detergent for hepatitis e virus rna. the detection rate was 1 hev-positive sample/2,218 blood donations. most samples (22/24) from viremic donors were negative for igg and igm against hev. | 2014 | 25340881 |
| frequent hepatitis e virus contamination in food containing raw pork liver, france. | food products containing raw pork liver are suspected to be vehicles for transmission of hepatitis e virus. four categories of food products, comprising 394 samples, were analyzed to determine hepatitis e virus prevalence. virus was detected in 3%-30% of the different categories. phylogenetic analysis showed high identity with human and swine sequences. | 2014 | 25340373 |
| foodborne transmission of hepatitis e virus from raw pork liver sausage, france. | 2014 | 25340356 | |
| fatal outcome of autochthonous hepatitis e in a patient with b cell lymphoma in southeastern france. | we describe a case of fatal fulminant hepatitis e concomitant to malignant b cell lymphoma in a 73-year-old french woman. infection was with an autochthonous hepatitis e virus of genotype 3f. frequent consumption of uncooked pig liver sausage (figatellu) was the only risk factor found. | 2015 | 25339404 |