Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| localization of immunogenic domains in the human immunodeficiency virus type 2 envelope. | highly immunogenic domains have not yet been defined in the extracellular protein of the human immunodefiency virus type 2 (hiv-2) envelope. in this study, six contiguous segments covering the entire hiv-2st envelope were amplified and cloned into a bacterial expression vector to localize the relative immunogenic reactivity of different regions of the molecule by western blot (immunoblot) analysis. our results demonstrate that the extracellular protein of the hiv-2 envelope contains highly immun ... | 1991 | 1714524 |
| attitudes, norms, and self-efficacy: a model of adolescents' hiv-related sexual risk behavior. | using data from a cross-sectional, statewide survey of 1,720 texas ninth graders in 13 school districts, a model of psychosocial predictors of human immunodeficiency virus (hiv)-related sexual risk behavior was tested. predictor variables in the model, based on variables from the theory of reasoned action and social learning theory, were attitudes, norms, self-efficacy, and behavioral intentions. attitudes, norms, and self-efficacy predicted 36.4% of the variance in the intention to limit the nu ... | 1992 | 1618632 |
| risks of cancer associated with long-term exposure to puva in humans: current status--1991. | since 1975 oral 8-methoxypsoralen administered in association with ultraviolet-a radiation (uva), (puva) has been widely used to treat psoriasis and other cutaneous diseases. puva is mutagenic, and in animals carcinogenic. prospective study of a cohort of patients with psoriasis who were first treated with puva in 1975-1976 has provided data on the carcinogenic risk of this treatment. there is a dose-dependent increase in the risk of squamous cell cancer of the skin associated with exposure to p ... | 1992 | 1617196 |
| compliance with zidovudine therapy in patients infected with human immunodeficiency virus, type 1: a cross-sectional study in a municipal hospital clinic. | to determine the extent of and clinical variables associated with zidovudine compliance. | 1992 | 1580296 |
| alcohol consumption and mortality in an american male population: recovering the u-shaped curve--findings from the normative aging study. | several prospective studies have suggested that moderate alcohol consumption may offer protection against total and coronary heart disease (chd) mortality. these studies have been criticized for failing to control for changes in drinking and the influence of comorbidity on consumption decisions. in the present study, we examined whether rates of death from all causes and from chd were related to overall consumption as well as variability in or problems with drinking. in 1973, a drinking question ... | 1992 | 1556854 |
| seroprevalence of human immunodeficiency virus in parturients at boston city hospital: implications for public health and obstetric practice. | we measured the seroprevalence of human immunodeficiency virus in women seeking reproductive services. | 1992 | 1530014 |
| corporate funding of human services agencies. | this article reviews national trends in the organization of corporate giving to human services agencies, examines how corporations make funding decisions, and reports the results of a case study of philanthropic giving among 29 companies in cambridge, massachusetts. the study found that most corporations use an informal rather than a formal process for making funding decisions, with many firms relying on tradition, social contacts, and intuition to guide allocations. suggestions that social serv ... | 1992 | 1514129 |
| computer-based interview for screening blood donors for risk of hiv transmission. | to test the ability of a computer-based interview to detect factors related to the risk of the human immunodeficiency virus (hiv) among potential blood donors and to determine donor reactions to the use of the interview. | 1992 | 1507376 |
| [the man and the woman behind the syndrome. a man and a woman behind the cronkhite-canada syndrome. a rare gastrointestinal polyposis with changes in the hair, skin and nails]. | 1992 | 1461020 | |
| human babesiosis in new york state: an epidemiological description of 136 cases. | epidemiological data on 136 cases of human babesiosis reported from laboratories and clinicians in the state of new york from 1982 to 1991 were reviewed. all but two patients, who had traveled to nantucket island in massachusetts, acquired disease in suffolk county, long island. the highest average age-group-specific annual incidence rates occurred among men > or = 80 years of age (7.72 per 100,000) and among women 70-79 years of age (3.61 per 100,000). seven patients (5%) had previously undergo ... | 1992 | 1457632 |
| perinatally acquired human immunodeficiency virus infection: extent of clinical recognition in a population-based cohort. massachusetts pediatric hiv surveillance working group. | to evaluate factors that may affect the timely diagnosis of children with human immunodeficiency virus (hiv) infection, we compared data derived from two population-based pediatric hiv studies. data from anonymous newborn hiv serosurveys were used to estimate the number of children born to hiv-seropositive mothers. a statewide active surveillance project determined the number of hiv-exposed children who had been clinically recognized. of 88,732 massachusetts newborn specimens tested anonymously ... | 1992 | 1454436 |
| vegetation structure influences the burden of immature ixodes dammini on its main host, peromyscus leucopus. | to determine whether the relative abundance of immature ixodes dammini (the vector of lyme disease and human babesiosis) is related to habitat structure, we examined tick burdens on their main host, the white-footed mouse (peromyscus leucopus), in 4 structurally diverse sites on great island, massachusetts, usa. vegetation structure at each site was quantified with respect to 25 habitat variables. principal components analysis was used to reduce this set of habitat variables to seven new and ort ... | 1992 | 1437266 |
| the relation between hospital experience and mortality for patients with aids. | to determine whether there is an association between mortality and hospital acquired immune deficiency syndrome (aids) experience for all aids-related diagnoses, and to determine whether the association is explained by differences in severity of illness, earlier discharge of terminally ill patients, or differences in resource use. | 1992 | 1433685 |
| a socioeconomic analysis of digital replantations resulting from home use of power tools. | forty-seven digits in 21 patients who sustained partial or complete amputations from the home use of power tools were replanted or revascularized during a 1-year period. this represented 69% of the microvascular surgery performed for hand injuries during that year. the cost of repairing an average of 2.4 digits was $7000 (surgeon's fee) plus $697 per hour (operating room fee), as per fiscal year 1987. postoperative hospitalization averaged 15 days at a cost of $15,679. hand rehabilitation averag ... | 1992 | 1430934 |
| who was morton prince? | morton prince, a boston neurologist, founded the journal of abnormal psychology in 1906 as an outlet especially for those who took a psychogenic view of neurotic disorders. through experiments with hypnotism, he added appreciably to knowledge of subconscious and coconscious mental processes; the dissociation of a personality (prince, 1905) still ranks as a classic. he early saw that studying normal people in the depth and detail with which one studied patients could make significant contribution ... | 1992 | 1430597 |
| human psittacosis linked to a bird distributor in mississippi--massachusetts and tennessee, 1992. | during april-may 1992, cdc was notified of a possible outbreak of psittacosis involving members of two families in massachusetts and tennessee who had recently purchased birds as pets. in the subsequent investigation of this problem, human psittacosis was defined as a fourfold rise in complement-fixing antibody titer to > or = 32 or a single titer of > or = 32 in a patient with fever and/or respiratory symptoms. this report summarizes the investigation of this problem. | 1992 | 1406575 |
| time trends in high-risk injection practices in a multi-site study in massachusetts: effects of enrollment site and residence. | time trends in needle sharing and bleach use were examined among needle users enrolled at drug abuse treatment and nontreatment sites in greater worcester, ma, from 1987 through 1989. substantial declines in high-risk behavior were found, with different trends at drug treatment versus nontreatment sites. the percentage of individuals sharing needles declined at treatment facilities but not at nontreatment sites. among those sharing, the proportion using bleach increased at both drug treatment an ... | 1992 | 1322686 |
| the health of children adopted from romania. | to determine the medical condition of romanian adoptees and the effects of the romanian orphanage system on their health. | 1992 | 1281241 |
| family planning during psychiatric hospitalization. | ongoing experience with development of family planning programs in psychiatric hospitals suggests that models must be flexible to allow for varying structures and traditions of institutions and for special needs of specific patient populations. however some issues, particularly those related to patients' rights and to usefulness of particular contraceptives, are broadly applicable. introduction of a family planning program for psychiatric patients is described. | 1976 | 1247094 |
| letter: lawyers, doctors and patients' rights. | 1976 | 1244559 | |
| respiratory colonization with pseudomonas putrefaciens after near-drowning in salt water. | pseudomonas putrefaciens, a marine organism infrequently found in human culture material, was repeatedly isolated from the sputum of a patient with pneumonia during a three-week period following a salt-water drowning accident. similar organisms were found in the water at the site of the accident in boston, and at ocean bathing beaches on nearby martha's vineyard. | 1975 | 1163489 |
| lead in human scalp hair: some factors affecting its variability. | the accumulation of lead in human scalp hair was compared in male and female children and adults from various locations in the united sates, japan, yugoslavia, iran, and south africa. the most significant variables which influenced the concentration of lead in hair were ingestion of lead-containing substances, exposure to lead of environmental origin, place of residence, site from which the hair specimen was sampled relative to its distance from the scalp, and age. the least significant variable ... | 1975 | 1141710 |
| milieu process during the residency turnover: the human cost of psychiatric education. | 1975 | 1119610 | |
| law-medicine notes. experimentation becomes a crime: fetal research in massachusetts. | 1975 | 1110708 | |
| massachusetts medical society. resolution concerning the safety and freedom of doctor mikhail shtern. | 1976 | 1107838 | |
| the politics of birth control, 1920-1940: the impact of professionals. | before the 1920s, a birth control movement arose in the united states out of socialist, feminist, and other radical groups concerned with women's rights and sexual freedom. after 1920 the birth control movement became gradually transformed into a respectable, nonradical reform cause, the recipient of large grants from big business, with women's rights secondary to an overriding concern with medical health and population control. this transformation was achieved through the professionalization of ... | 1975 | 1102468 |
| the man who was to be. introductory note to "black patient white therapist: a case report.". | 1975 | 1099042 | |
| isolation and characterization of vibrio parahaemolyticus from cape cod soft-shell clams (mya arenaria). | vibrio parahaemolyticus was isolated from soft-shell clams (mya arenaria) taken from 10 different clamming areas on cape cod, mass., during july and august 1972. direct plating on thiosulfate-citrate-bile salts-sucrose agar was found to be superior to either direct plating on vanderzant modified salt starch agar or enrichment with trypticase soy broth containing 7% salt for isolation from clam samples. morphological and biochemical characteristics of 33 isolates from 30 samples generally conform ... | 1975 | 1096817 |
| childhood lead poisoning and legislative action. | 1975 | 1081566 | |
| a comparison of two abortion-related legal inquiries. | 1975 | 1080506 | |
| factors involved in immunization program for swine influenza. | the decision to undertake a nationwide program of vaccination against swine influenza requires assessment of the status of immunity of those in various age groups in our population against this agent. pools of serum were collected from persons born in the years from 1889 to 1943; they were tested for hemaggultinin inhibiting (hi) antibody against the hsw 1n1 influenza virus strains isolated in 1931 and 1976. the titers secured serve as an indication of the average level of immunity of those of d ... | 1976 | 1034440 |
| human babesiosis on nantucket island: transmission by nymphal ixodes ticks. | in order to identify potential vectors of human babesiosis (babesia microli) in southern massachusetts, i attempted to transmit the infection via nymphal ticks of that species found to be most abundant on reservoir hosts (peromyscus leucopus) in nature. mice were collected at frequent intervals throughout a year in a known enzootic focus on nantucket island, and ticks were removed by hand. ticks of only two species were present; larvae and nymphs of ixodes scapularis were about 10 times as numer ... | 1976 | 1008124 |
| biomedical research: a view from the state legislature. | 1976 | 931726 | |
| boston exanthem agent: echovirus 16. | 1977 | 920685 | |
| role of midwives. | dr. alfano (new england journal of medicine 296: 1126, 1977) is certainly entitled to his personal opinions, but when they appear in a major publication in a setting that calls for factual information, they cannot go unchallenged. midwives have played and continue to play a major part in maternal-infant services in many advanced european countries. combined midwife-physician services in sweden, finland, japan, netherlands, denmark, norway, and switzerland produced infant mortality rates in 19 ... | 1977 | 876307 |
| peer sex education training and evaluation. | human sexuality has been recognized as an important developmental, emotional, and medical concern on the college campus. the peer sex education program at the university of massachusetts/amherst has been developed as a model for the use of trained students in an educational, referral, and counseling role. this paper describes the program and outlines the methodology used in the documentation and evaluation of various program aspects. aspects described include the program's rationale and backgrou ... | 1977 | 857687 |
| renal transplantation: a twenty-five year experience. | boston has played a significant role in the development of renal transplantation. in boston was performed the first successful isograft between identical twins (1954) the first successful allograft between fraternal twins (1959) and the first successful allograft from a cadaveric donor (1962). an immunosuppressive drug was also described in boston by hematologists schwartz and dameschek (1959) and modified for renal transplantation in dogs (1961) and used for the first time in a human recipient ... | 1976 | 791162 |
| historical reflections on the sesquicentennial of the founding of the boston prison discipline society (1825-1854). | 1975 | 779872 | |
| general washington and the patriot soldiers. they won a war with little food. a bicentennial study. | the troops in the first action of the american revolution in massachusetts were well provisioned through the efforts of joseph trumbull of connecticut, whom the second continental congress appointed commissary general, at general washingtion's request. the ration, as ordered, would have provided-by today's standards-more calories, twice as much protein, and adequate minerals and vitamins, except possible vitamin a and ascorbic acid. unfortunately, all items in the ration were seldom available to ... | 1976 | 770557 |
| teaching occupational health to physicians. | a comprehensive training program for physicians interested in occupational health is presented. the objectives are to prepare students to identify and prevent occupational disease, with an emphasis on the development of a public health perspective. seven content areas are described: epidemiology and biostatistics, toxicology, industrial hygiene, safety and ergonomics, policy issues, administration, and clinical aspects. these are organized in a matrix to provide appropriate levels of training fo ... | 1978 | 691028 |
| federal preclusion of state certificate-of-need exemptions for research and education expenditures. | the national health planning and resources development act of 1974 requires each state to enact a certificate-of-need program in compliance with federal standards in order to remain eligible for continued receipt of federal funds for health resource development after 1980. this note contends that the act and related hew regulations preclude states from exempting health care facilities' research expenditures and education expenditures from the scope of the states' certificate-of-need programs. th ... | 1978 | 685985 |
| managing public health risks: the swine flu immunization program revisited. | in this comment, the massachusetts commissioner of public health views the federal government's 1976-77 swine flu immunization program, which was sharply criticized by dr. cyril wecht in a recent article in this journal, as a classic example of a public policy decision made under conditions of stress and uncertainty. once the responsible government officials had made a public commitment to immunize the entire populace of the united states, he contends, they found it very difficult to reformulate ... | 1978 | 685984 |
| what's happening to federally aided health programs under state departments of human resources. | 1978 | 652943 | |
| the incompetent's right to die: the case of joseph saikewicz. | 1978 | 624618 | |
| leptospirosis in new england. | although rarely reported in humans in new england, leptospirosis is enzootic in western and central massachusetts. recently there were three cases of leptospira interrogans, serotype var pomona, in easthampton, mass. our study and others indicate a potential for waterborne epidemics in humans. | 1977 | 578899 |
| human babesiosis on nantucket island. evidence for self-limited and subclinical infections. | 1977 | 561308 | |
| human babesiosis on nantucket island. clinical features. | between 20 july and 15 octoboer 1975, five cases of human infection with babesia microti were diagnosed on nantucket island, massachusetts. the illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. none of the patients had a history of splenetomy. although all patients responded symptomatically to treatment with oral chloroquine phosphate, parasitemia and fatigue frequently persisted for several weeks ... | 1977 | 556920 |
| age as a function in the development of sodium-related hypertension. | the populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by the same factors. a possible common denominator in the development of any chronic elevation of blood pressure is the need for the kidney to increase urine volume to promote sodium e ... | 1979 | 510240 |
| human babesiosis on nantucket island, usa: description of the vector, ixodes (ixodes) dammini, n. sp. (acarina: ixodidae). | 1979 | 439119 | |
| pandemic influenza 1918. | 1979 | 394807 | |
| the osler medal essay: height, weight, and health: anthropometric study of human growth in nineteenth-century american medicine. | 1979 | 389320 | |
| babesia infections in man. | only recently has it been recognized that hemotropic animal parasites of the genus babesia are also human pathogens. similar to malaria in both symptoms and laboratory findings, acute babesiosis generally results in self-limited illness, but it can be fatal in the asplenic patient. the widely disseminated vector tick, ixodes dammini, can transmit infection at each stage of its development, larva and nymph as well as adult. | 1979 | 376427 |
| creutzfeldt-jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. | the worldwide epidemiology of creutzfeldt-jakob disease (cjd) is presented from an analysis of 1,435 patients. in the united states, the average annual mortality rate is at least 0.26 deaths per million. temporal-spatial clustering of cases was not found in the united states, but reports from other countries indicate that such clustering does occur. fifteen percent of the cases were of the familial type, suggesting a genetic susceptibility to infection. iatrogenic transmission by corneal transpl ... | 1979 | 371520 |
| castle: right man, time, and place. | 1978 | 363006 | |
| [the lesson of the practolol drama; can adverse effects of drugs be recognized as such sooner?]. | 1978 | 360080 | |
| enhanced anticaries action from drinking water containing 5 ppm fluoride. | dental examinations were conducted on 1,878 adolescent schoolchildren native to seven us cities in five states, where the water was fluoride-deficient, fluoridated, or contained approximately 5 ppm of naturally occurring fluoride. dental caries experience was considerably lower in all the communities with fluoridated water than in boston, which had water deficient in fluoride, and ranged from 38% to 83% fewer mean dmf for the children in the regions with fluoridated water than for the children i ... | 1979 | 282343 |
| program evaluation as health services research. | evaluation of health program is necessary for more rational allocation of scarce resources. steps in evaluation include: 1)specification of the program goals, 2) description of the program, 3) definition and measurement of outcome, 4) assessment of intervening variables, 5) analysis of data, and 6) implementation of findings. examples from impirical evaluation studies are presented to illustrate one practical application of these steps. while the random controlled trial is a most powerful tool, ... | 1978 | 281768 |
| a regional cardiac care program: planning & development. | five hospitals in northeastern massachusetts joined together to provide a cardiac care nursing educational program for staff nurses. their mutual effort reduced costs for each hospital and maximized the use of human and material resources. the endeavor has been successful, based upon a number of evaluation factors. | 1979 | 253743 |
| viral exposure and autism. | 1979 | 222139 | |
| diet and cancer of endocrine target organs. | the role of diet in the etiology of cancer of the breast and endometrium is considered. geographic variation in rates, effects of migration, consequences of exogenous hormone use, and other epidemiologic factors are reviewed. cancer of the endometrium is related to diet probably through simple caloric excess. the excess is reflected in obesity and the consequent overproduction of estrone, a natural but carcinogenic human estrogen. diet may also influence breast cancer risk somewhat through the s ... | 1977 | 195711 |
| opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study. | the heroin self-administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists--naloxone or naltrexone) and unblocked (no antagonist) conditions. in the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. possible explanations for these results are discussed along with their implications for treatment. | 1976 | 184054 |
| natural infection of dogs on cape cod with rickettsia rickettsii. | four isolates of rickettsiae from sick dogs on cape cod, mass., were serologically identical to isolates of rickettsia rickettsii from human patients with rocky mountain spotted fever. the antigenic analysis used the indirect fluorescent-antibody test and antisera prepared in mice to each of the isolates and to reference strains of r. rickettsii and rickettsia montana. serological responses of infected dogs were specific for r. rickettsii, although antibodies to r. montana were also detected in ... | 1979 | 114534 |
| phenotypic and epidemiologic correlates of auxotype in neisseria gonorrhoeae. | previous studies from seattle, wash., suggested that strains of neisseria gonorrhoeae which require arginine, hypoxanthine, and uracil (arg-hyx-ura- auxotype) are unifomly highly susceptible to penicillin g, are relatively resistant to complement-dependent killing by heated, pooled human serum, and are associated with disseminated gonococcal infection. for further study of the epidemiology of these strains and for analysis of the susceptibility to penicillin, serum sensitivity, and the nutrition ... | 1978 | 98600 |
| mortality from leukaemia and cancer in shipyard nuclear workers. | a review of death certificates in new hampshire, maine, and massachusetts for 1959-77 yielded a total of 1722 deaths among former workers at the portsmouth naval shipyard where nuclear submarines are repaired and refuelled. next of kin were contacted for 592. all deaths under age 80 were classified as being in former nuclear or non-nuclear workers depending on information supplied by next of kin. with u.s. age-specific proportional cancer mortality for white males as a standard, the observed/exp ... | 1978 | 76937 |
| clinical spectrum of gonococcal infection in women. | the medical records of 278 women infected with neisseria gonorrhoeae during a 6-month period were reviewed. these represented 75% of the infections in women at boston city hospital during this time. women who presented to the venereal-disease clinic because they had had contact with an infected man and women who were found to be infected during routine examinations in the obstetrics-and-gynaecology clinic were usually free of symptoms or had non-specific symptoms such as vaginal discharge. howev ... | 1977 | 68279 |
| tumor-associated antigen levels (carcinoembryonic antigen, human chorionic gonadotropin, and alpha-fetoprotein) antedating the diagnosis of cancer in the framingham study. | determinations of carcinoembryonic antigen (cea), human chorionic gonadotropin (hcg), and alpha-fetoprotein (afp) were done by use of frozen serum samples antedating the diagnosis of cancer for 9 pancreatic and 8 gastric carcinoma patients from the framingham heart study. the longest intervals for elevated antigens before cancer diagnosis were 10 months for cea and 26 months for hcg. (the single elevated afp was found in a sample 10 days before clinical diagnosis.) samples from 31 controls match ... | 1977 | 68118 |
| eastern equine encephalitis in massachusetts, 1957-1976. a prospective study centered upon analyses of mosquitoes. | reappearance of eastern equine encephalitis (eee) in massachusetts residents in the 1970's provided an opportunity to assess the predictive value of data on rainfall, eee in horses, and carriage of eee virus (eeev) by mosquitoes, factors which had been studied annually since the last eee outbreak in 1955-1956. the cycle of multiple cases during 1973-1975 started in a second consecutive year of rainfall that exceeded the annual mean by more than 20 cm, conditions recapitulating the 1955-1956 expe ... | 1978 | 23676 |