Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| phase iii vehicle-controlled, multi-centered study of topical alitretinoin gel 0.1% in cutaneous aids-related kaposi's sarcoma. | this randomized, double-blind and vehicle-controlled phase iii study was conducted to evaluate the efficacy and safety of alitretinoin gel 0.1% for the topical treatment of the cutaneous lesions of aids-related kaposi's sarcoma (ks). | 2001 | 11705307 |
| induction of a trail-mediated suicide program by interferon alpha in primary effusion lymphoma. | gammaherpes viruses are often detected in lymphomas arising in immunocompromised patients. we have found that azidothymidine (azt) alone induces apoptosis in epstein barr virus (ebv) positive burkitt's lymphoma (bl) cells but requires interferon alpha (ifn-alpha) to induce apoptosis in human herpes virus type 8 (hhv-8) positive primary effusion lymphomas (pel). our analysis of a series of aids lymphomas revealed that ifn-alpha selectively induced very high levels of the death receptor (dr) tumor ... | 2001 | 11704827 |
| serological and immunohistochemical detection of human herpesvirus 8 in kaposi's sarcoma after immunosuppressive therapy for bullous pemphigoid. | kaposi's sarcoma (ks) developed in an 87-year-old human immunodeficiency virus-negative woman from hokkaido island 4 months after oral administration of prednisolone for the treatment of bullous pemphigoid (bp), and rapidly disseminated to almost the entire body within 2 months. the open reading frame (orf) 59 and orf73 proteins encoded by human herpesvirus 8 (hhv-8) were detected immunohistochemically in the nuclei of the tumour cells of ks. the protein coded by orf73, latent protein, was detec ... | 2001 | 11703292 |
| molecular anatomy of ccr5 engagement by physiologic and viral chemokines and hiv-1 envelope glycoproteins: differences in primary structural requirements for rantes, mip-1 alpha, and vmip-ii binding. | molecular analysis of ccr5, the cardinal coreceptor for hiv-1 infection, has implicated the n-terminal extracellular domain (n-ter) and regions vicinal to the second extracellular loop (ecl2) in this activity. it was shown that residues in the n-ter are necessary for binding of the physiologic ligands, rantes (ccl5) and mip-1 alpha (ccl3). vmip-ii, encoded by the kaposi's sarcoma-associated herpesvirus, is a high affinity ccr5 antagonist, but lacks efficacy as a coreceptor inhibitor. therefore, ... | 2001 | 11700073 |
| human herpes virus-8 is not associated with primary central nervous system lymphoma in hiv-negative patients. | primary central nervous system lymphomas (pcnsl) are derived from germinal center b cells. recent molecular studies indicate that the tumor cells or their precursors have experienced antigenic stimulation. attractive candidates for such antigens are pathogens with the capacity to reside in the brain. the aim of the present study was to evaluate whether human herpes virus (hhv)-8 is involved in the pathogenesis of pcnsl. a series of 46 pcnsl, 31 from hiv-negative and 15 from hiv-positive patients ... | 2001 | 11699563 |
| [preliminary study of human herpesvirus type 8 infection in pregnant women in dakar (senegal)]. | hhv8 was discovered in 1994 and few studies on this virus have been conducted in africa. the virus is related to kaposi sarcoma, an opportunistic affection occurring during hiv infection. no studies have been carried out on this subject in senegal, a country known for its low ks prevalence even among people living with hiv/aids. thus it will be interesting to explore this field. the aim of our study has been first, to demonstrate the presence of hhv8; second, to evaluate sero-prevalence of the i ... | 2001 | 11681216 |
| [human herpesvirus 8 and transfusion safety]. | 2001 | 11675294 | |
| [pathogenic and epidemiologic power of human herpesvirus 8 infections]. | 2001 | 11675293 | |
| human herpesvirus-8 seroconversions after renal transplantation. | human herpesvirus-8 (hhv-8) is a new human herpesvirus that is clearly associated with kaposi's sarcoma (ks). a previous study has reported that the prevalence of ks in a cohort of renal transplant recipients with previous hhv-8 infection was 28% and two other studies have shown that ks can be linked to hhv-8 seroconversion after graft. the aim of this study was to evaluate the hhv-8 seroconversion rate in a cohort of renal allograft recipients in paris. | 2001 | 11602862 |
| kshv-k5 inhibits phosphorylation of the major histocompatibility complex class i cytoplasmic tail. | the carboxy-terminal region of major histocompatibility complex class i (mhc i) molecules is required for the rapid internalization mediated by kaposi's sarcoma-associated herpesvirus (kshv) proteins k3 and k5. the cytoplasmic tail of mhc i contains highly conserved serine phosphorylation sites that have been implicated in intracellular trafficking. indeed, in vivo labeling experiments reveal a lack of mhc i phosphorylation in k5-transfected hela cells. phosphorylation of the mhc i tail was rest ... | 2001 | 11601908 |
| simultaneous occurrence of epstein-barr virus associated hodgkin's disease and hhv-8 related multicentric castleman's disease: a fortuitous event? | previous serological or molecular studies by means of the polymerase chain reaction have failed to show an association between classic hodgkin's disease (hd) and human herpesvirus 8 (hhv-8). using immunohistochemistry, this study re-examines (with anti-lna1 antibody) the possible association of hhv-8 with hd, particularly in human immunodeficiency virus (hiv) infected patients. hhv-8 was not detected in the reed sternberg cells of the cases examined (33 hiv negative and 17 hiv positive), thus co ... | 2001 | 11577129 |
| murine gammaherpesvirus-68-induced interleukin-10 increases viral burden, but limits virus-induced splenomegaly and leukocytosis. | based on its genomic sequence and its pathogenesis, murine gammaherpesvirus-68 (gammahv-68) has been established as a tractable model for the study of viral infections caused by the human gammaherpesviruses, epstein-barr virus or human herpesvirus-8. despite significant advances, the mechanisms responsible for gammahv-68-induced alterations in the protective host response, and the accompanying virus-induced leukocytosis, are not clear. in the present study, we questioned whether viral infection ... | 2001 | 11576228 |
| quantitative, fluorogenic probe pcr assay for detection of human herpesvirus 8 dna in clinical specimens. | a quantitative, fluorescence-based pcr assay (taqman-based system) was developed for detection of human herpesvirus 8 (hhv-8) dna in clinical specimens. primers and probes chosen from each of five 10-kb segments from the unique region of the hhv-8 genome were evaluated for sensitivity with dilution series of dna extracted from a cell line (bcbl-1) that harbors hhv-8 dna. although several of the primer-probe sets performed similarly with bcbl-1 dna that had been diluted in water, their performanc ... | 2001 | 11574569 |
| [human herpes virus and malignancies]. | two type of human herpes viruses, type 4(epstein barr virus, ebv) and type 8(hhv8) are known to cause malignancies. among those, ebv is the very most popular human oncovirus. it can cause malignant lymphomas of various subtypes including burkitt's lymphoma, opportunistic lymphomas, pyothorax-associated lymphoma, nasal t/nk cell lymphoma, hodgkin's disease and a part of diffuse large cell lymphomas. hhv8 is a new member of human oncovirus associating with primary effusion lymphoma, a part of soli ... | 2001 | 11573285 |
| treatment of kaposi sarcoma with oral administration of shark cartilage in a human herpesvirus 8-seropositive, human immunodeficiency virus-seronegative homosexual man. | 2001 | 11559209 | |
| seroprevalence of kaposi's sarcoma-associated herpesvirus infection among blood donors from texas. | kaposi's sarcoma-associated herpesvirus (kshv), a gammaherpesvirus recently discovered among aids patients with kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. while a number of studies have assessed kshv infection among u.s. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of kshv infection across different geographic regions of the u.s. blood supply. the goal of the prese ... | 2001 | 11557184 |
| seroprevalence of human herpes virus 8 antibody in populations at high or low risk of transfusion, graft, or sexual transmission of viruses. | the routes of transmission of human herpes virus 8 (hhv-8) remain unclear. in particular, hhv-8 transmission by blood components and organ transplantation is still debated and raises public health issues. the objective of this study was to determine the prevalence of anti-hhv-8 in selected populations of persons or patients with or without risk factors for the transmission of viral infections, in order to determine the routes of hhv-8 transmission. | 2001 | 11552068 |
| seroprevalence of human herpesvirus 8 in okinawa, japan. | 2001 | 11544407 | |
| a novel gamma 2-herpesvirus of the rhadinovirus 2 lineage in chimpanzees. | old world monkeys and, recently, african great apes have been shown, by serology and polymerase chain reaction (pcr), to harbor different gamma2-herpesviruses closely related to kaposi's sarcoma-associated herpesvirus (kshv). although the presence of two distinct lineages of kshv-like rhadinoviruses, rv1 and rv2, has been revealed in old world primates (including african green monkeys, macaques, and, recently, mandrills), viruses belonging to the rv2 genogroup have not yet been identified from g ... | 2001 | 11544194 |
| low incidence of human herpesvirus 8 in bone marrow samples from brazilian patients with multiple myeloma. | 2001 | 11528101 | |
| safety of italian plasma for fractionation with respect to contamination with human herpes virus 8. | 2001 | 11520418 | |
| herpesvirus type 1-8 in bal fluid from hiv-1-infected patients with suspected pneumonia and from healthy individuals. | pneumonia is still a major problem in human immunodeficiency virus (hiv)-infected patients, and despite extensive investigation the aetiology remains unknown in many cases. the prevalence of the eight human herpesviruses was determined by polymerase chain reaction in 91 samples of bronchoalveolar lavage (bal) fluid from 72 hiv-infected patients with 91 episodes of suspected pneumonia. the presence of herpesviruses was related to clinical and immunological findings and the prevalence of herpesvir ... | 2001 | 11510785 |
| latency-associated nuclear antigen encoded by kaposi's sarcoma-associated herpesvirus interacts with tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cells. | the latency-associated nuclear antigen (lana) is constitutively expressed in cells infected with the kaposi's sarcoma (ks) herpesvirus (kshv), also referred to as human herpesvirus 8. kshv is tightly associated with body cavity-based lymphomas (bcbls) in immunocompromised patients infected with human immunodeficiency virus (hiv). lana, encoded by open reading frame 73 of kshv, is one of a small subset of proteins expressed during latent infection and was shown to be important in tethering the vi ... | 2001 | 11507221 |
| activation of nf-kappab by the human herpesvirus 8 chemokine receptor orf74: evidence for a paracrine model of kaposi's sarcoma pathogenesis. | infection with human herpesvirus 8 (hhv-8), also known as kaposi's sarcoma (ks)-associated herpesvirus, is necessary for the development of ks. the hhv-8 lytic-phase gene orf74 is related to g protein-coupled receptors, particularly interleukin-8 (il-8) receptors. orf74 activates the inositol phosphate/phospholipase c pathway and the downstream mitogen-activated protein kinases, jnk/sapk and p38. we show here that orf74 also activates nf-kappab independent of ligand when expressed in ks-derived ... | 2001 | 11507211 |
| expression of kaposi's sarcoma-associated herpesvirus g protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas. | kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) encodes a g protein-coupled receptor (vgpcr) in open reading frame (orf) 74, which is homologous to human chemokine receptors. kshv vgpcr is constitutively active and induces vegf-mediated angiogenesis. previous studies have shown that orf 74 is transcribed as part of a bicistronic message containing orf k14 upstream of orf 74, with an early lytic pattern of expression. we have now extended these studies by analyzing three different kshv-posit ... | 2001 | 11504542 |
| emerging viruses and transfusion. | the development of new technologies leads to the discovery of new viruses. for each of these new infectious agents, their possible relevance to blood transfusion needs to be assessed. the questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence, and the availability of screening assays. since 1995, three new viruses have been identified and extensively studied. | 2001 | 11499963 |
| classic kaposi's sarcoma associated with human herpesvirus 8 infection in a 13-year-old male: a case report. | classic kaposi's sarcoma (ks) is rare in children. although its etiology is not fully understood, human herpesvirus 8 (hhv-8) is present in the angiogenic lesions. we report an hiv-negative, 13-year-old patient of sicilian descent with hhv-8-associated classic ks to facilitate the diagnosis and treatment of this entity in children. | 2001 | 11489800 |
| high incidence of classic kaposi's sarcoma in mantua, po valley, northern italy (1989-1998). | the incidence of classic kaposi's sarcoma was estimated in the province of mantua, po valley, northern italy, yielding age-standardized rates of 2.5/100 000 men and 0.7/100 000 women (1989-98). elevated rates in the rural zone of viadana/sabbioneta (5.0/100 000 men and 2.8/100 000 women) are among the highest so far reported for italian communities. | 2001 | 11487269 |
| is volcanic soil a cofactor for classic kaposi's sarcoma? | 2000 | 11484811 | |
| hiv type 1 tat protein is a survival factor for kaposi's sarcoma and endothelial cells. | the hiv-1 tat protein has been directly implicated in the pathogenesis of aids-related kaposi's sarcoma (ks); however, its effects on ks spindle-shaped and endothelial cell apoptosis are largely unexplored. since susceptibility to apoptosis is relevant for tumor development and response to therapy, we investigated the effects of tat on ks and endothelial cell survival from apoptosis. the effect of tat was evaluated in three ks cell lines (ks-imm, ks-c1, and ks-l3) exposed to the chemotherapy age ... | 2001 | 11461682 |
| no association between human herpesvirus 8 and arsenical skin cancers. | 2001 | 11454097 | |
| susceptibility of mouse mammary glands to murine gammaherpesvirus 72 (mhv-72) infection: evidence of mhv-72 transmission via breast milk. | murine gammaherpesvirus 72 (mhv-72) is a virus of wild rodents and serves as a convenient small animal model to understand the pathogenesis of epstein-barr virus (ebv) and human herpesvirus 8 (hhv8) infection. in laboratory mice mhv-72 causes an acute infection of lung epithelial cells and establishes the latency in b lymphocytes. in this study, we investigated athymic nude and immunocompetent mice for distribution of virus in organs after infection with mhv-72. ten days following subcutaneous d ... | 2001 | 11453700 |
| increased detection of herpesvirus dna in idiopathic pulmonary fibrosis. | 2001 | 11451937 | |
| ebv and malignant lymphoma with special emphasis on pyothorax-associated lymphoma. | 2001 | 11443856 | |
| etiologic factors in soft tissue sarcomas. | soft tissue sarcomas account for about 1% of all malignancies. the increase in incidence of soft tissue sarcomas during the recent decades may predominantly be attributed to aids-related kaposi's sarcoma; when this tumor is excluded, conclusive evidence for an age-adjusted increase is lacking. beside the well investigated role of the human immunodeficiency virus 1 (hiv-1) and the human herpesvirus 8 (hhv-8) in the tumorigenesis of aids-related kaposi's sarcoma and several inherited disorders, co ... | 2001 | 11441293 |
| negative human herpesvirus 8 serology in sarcoidosis. | 2001 | 11437314 | |
| transcription pattern of human herpesvirus 8 open reading frame k3 in primary effusion lymphoma and kaposi's sarcoma. | human herpesvirus 8 (hhv-8) is found in immunoblastic b cells of patients with multicentric castleman's disease (mcd) and, predominantly in a latent form, in primary effusion lymphoma (pel) cells and kaposi's sarcoma (ks) spindle cells. recent studies have shown that upon reactivation, hhv-8 expresses factors that downregulate major histocompatibility class i proteins and coactivation molecules and that may enable productively infected cells to escape cytotoxic t lymphocytes and natural killer c ... | 2001 | 11435597 |
| comparative pathobiology of hiv- and siv-associated lymphoma. | 2001 | 11429114 | |
| kissing and kaposi's sarcoma. | 2001 | 11427980 | |
| novel properties of the cyclin encoded by human herpesvirus 8 that facilitate exit from quiescence. | viral dna replication is generally dependent upon circumventing host cell cycle control to force s phase entry in an otherwise quiescent cell. here we describe novel attributes of the cyclin encoded by human herpesvirus 8 (k cyclin) that enable it to subvert the quiescent state. k cyclin is most similar to the mammalian d-type cyclins in primary sequence but displays properties more akin to those of cyclin e. k cyclin (like cyclin e) can autonomously couple with its cognate cdk subunit and local ... | 2001 | 11423981 |
| biology of kaposi's sarcoma. | kaposi's sarcoma (ks) is an angioproliferative disease occurring in several different clinical-epidemiological forms that, however, share the same histological traits and are all associated with infection by the human herpesvirus 8 (hhv8). ks initiates in a context of immune dysregulation characterised by cd8+ t cell activation and the production of th1-type cytokines that induce a generalised activation of endothelial cells leading to adhesion and tissue extravasation of lympho-monocytes, spind ... | 2001 | 11423257 |
| kshv/hhv8-associated lymphoproliferations in the aids setting. | kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus 8 (hhv8) is associated with two lymphoproliferative disorders in the aids setting, primary effusion lymphoma (pel) and the plasma cell variant of multicentric castleman's disease (mcd). in pel, kshv persists in a latent form in most lymphoma cells, although viral production has been seen infrequently. in mcd, the viral gene expression pattern is less restrictive, virus production appears to occur and to correlate with the severi ... | 2001 | 11423254 |
| epidemiology of aids-related tumours in developed and developing countries. | aids-associated illnesses include kaposi's sarcoma (ks), non-hodgkin's lymphoma (nhl), and, since 1993, invasive cervical cancer (icc). between 1988 and 1998, among aids cases reported in western europe, 9.6% had ks and 3.9% had nhl as aids-defining illnesses. between 1988 and 1998, the frequency of ks decreased from 13.4 to 6.4%, while nhl increased from 3.8 to 5.3%. estimates of the relative risk (rr) of neoplasms in hiv-seropositive populations came from population-based cancer and aids regis ... | 2001 | 11423251 |
| treatment of hiv-associated multicentric castleman's disease with oral etoposide. | multicentric castleman's disease (mcd) is a lymphoproliferative disorder that can be defined based upon both clinical and pathological characteristics. the clinical features of this frequently fatal disease include fever, generalized lymphadenopathy, fatigue, splenomegaly, hepatomegaly, and pancytopenia. recently, severe forms of this disease have been diagnosed in hiv positive patients. human herpesvirus type 8 (hhv-8) dna sequences have been detected in peripheral blood mononuclear cells (pbmc ... | 2001 | 11421297 |
| bone marrow involvement in lymphomas with hemophagocytic syndrome at presentation: a clinicopathologic study of 11 patients in a western institution. | hemophagocytic syndrome (hps) is a clinicopathologic syndrome that can reveal a non-hodgkin's lymphoma. the pathologic features of lymphoma associated with hps remain ill defined. we studied 11 lymphomas associated with hps on initial bone marrow biopsies, consecutively diagnosed during a 6-year period in a western institution. there were seven diffuse large b-cell lymphomas (dlbcls), three t-cell lymphomas (one peripheral t-cell lymphoma unspecified, two hepatosplenic gammadelta t-cell lymphoma ... | 2001 | 11420457 |
| prevalence and distribution of hhv-8 in different subpopulations, with and without hiv infection, in spain. | to estimate the seroprevalence of hhv-8 in several spanish subpopulations with different risk levels of acquiring hiv-1 infection and from different geographical regions. | 2001 | 11416719 |
| exogenous fibroblast growth factor-2 induces a transformed phenotype in vascular kaposi's sarcoma-like cells. | vascular ttb cells derive from murine kaposi's sarcoma-like dermal lesions and share several phenotypic features with aids-associated ks spindle cells. we have recently reported that fibroblast growth factor-2 (fgf-2) promotes dramatic cytoskeletal and morphological alterations in ttb cells, concomitant with the induction of an autocrine loop for hepatocyte growth factor and a relocalization of the urokinase receptor. since all these alterations are hallmarks of cell transformation. we attempted ... | 2000 | 11409912 |
| utility of hhv8 rna detection for differentiating kaposi's sarcoma from its mimics. | the diagnostic distinction of atypical vascular lesion or angiomatoid/hemosiderotic dermatofibroma and kaposi's sarcoma can be difficult, especially in aids patients. given the strong association between human herpes virus 8 (hhv8) and kaposi's sarcoma, this study attempts to determine if hhv8 rna detection by reverse transcription (rt) in situ polymerase chain reaction (pcr) could help in differentiating these entities. | 2001 | 11401668 |
| an atypical aggressive kaposi's sarcoma in a hiv-negative bisexual man. | we describe a case of kaposi's sarcoma in a previously healthy 35-year-old bisexual west indian man of african descent who was seronegative for the human immunodeficiency virus (hiv) and human t-cell lymphotropic virus-1 (htlv-1) and who presented with extensive mucocutaneous lesions, weight loss, visceral and generalized lymph node involvement, poor response to combination therapy with vinblastine and interferon alfa-2a, and a short survival of eight months from the onset of illness. this is th ... | 2001 | 11398296 |
| suppression of oncogenic viral interferon regulatory factor (virf) of kaposi's sarcoma-associated herpesvirus by ribozyme-mediated cleavage. | kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (kshv/hhv8) has been etiologically associated with several malignancies including kaposi's sarcoma and primary effusion lymphoma. oncogenic viral interferon regulatory factor (virf) encoded by kshv orf-k9 is a homologue of cellular interferon regulatory factor (irf), and has been demonstrated to inhibit type i/ii interferon signal transduction and transform nih3t3 cells through the interactions with irf-1, irf-3, and cbp/p300 proteins. ... | 2001 | 11393281 |
| aids-related body cavity-based lymphoma. a case report. | body cavity-based lymphomas are rare malignancies in human immunodeficiency virus (hiv)-infected patients, but because of their unusual clinical, morphologic and immunophenotypic features, they are recognized as a distinct subgroup of lymphomas connected to human herpesvirus 8 (hhv-8) infection. | 2001 | 11393078 |
| kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and multiple myeloma in south africa. | kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (kshv/hhv-8) has been implicated in the etiopathogenesis of multiple myeloma. although the association is biologically plausible and attractive, conflicting data have been reported, including evidence against the involvement of kshv in the pathogenesis of the disease. the purpose of this study was to determine the relationship between kshv and myeloma in blacks in south africa, in whom the disease is not uncommon and the seroprevalence of ... | 2001 | 11385317 |
| induction of human immunodeficiency virus 1 replication by human herpesvirus 8. | human immunodeficiency virus 1 (hiv-1)-infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (hhv-8, also known as kaposi sarcoma-associated herpesvirus [kshv]). previous studies have demonstrated that coinfection with herpesviruses can modulate hiv-1 replication. this can occur either through direct interaction between the 2 viruses or through secondary effects resulting from the release of ... | 2001 | 11371231 |
| the trouble with tumors. | kaposi's sarcoma (ks) is a type of cancer thought to be caused by the human herpesvirus-8 (hhv-8). ks causes cancerous lesions on or beneath the skin. the disease may overpower the immune system and, in some cases, cause death. studies show that the transmission of hhv-8 is linked to sexual contact, either genital or oral, and that people cannot contract ks without first having hhv-8. the recent decrease in the number of ks cases has been attributed to the use of highly active antiretroviral the ... | 1999 | 11367167 |
| new approaches to hiv treatment: interview with robert gallo. m.d. interview by john s. james. | dr. robert c. gallo, director of the institute of human virology, discusses the institute's mission, funding, hiv treatment research investigations, and his own personal projects. dr. gallo explains the working mechanics of the macrophage-derived chemokine, a chemokine known to effectively block hiv; reasons why the national institute of health (nih) grants need to be hypothesis-driven; what has been learned about human chorionic gonadotropin's potential as a treatment for kaposi's sarcoma; and ... | 1997 | 11364917 |
| anal neoplasia in persons with hiv infection. | aside from the neoplasms that are clearly related to immunodeficiency, such as non-hodgkin's lymphoma and kaposi's sarcoma, numerous observations have also shown an association between hiv infection and the incidence of cervical and anal neoplasms. human papillomavirus (hpv) is the etiologic factor in anogenital neoplasms, although the mechanisms of the association are not clearly understood. it is believed that several hpv genes are critical in the malignant cell transformation process. an etio ... | 1996 | 11363714 |
| longitudinal sero-reactivity to human herpesvirus 8 (kshv) in the swiss hiv cohort 4.7 years before ks. | the relationship between viral infection with kaposi sarcoma-associated herpesvirus (kshv) and the onset of kaposi sarcoma (ks) in aids patients is incompletely understood. this study investigates the use of three serological assays to predict the development of ks in hiv-positive patients. serially collected serum samples from 36 patients with ks and matched controls in the swiss hiv cohort study (shcs) were analyzed in a case control study. three serologic assays to detect antibodies against k ... | 2001 | 11360248 |
| hhv8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype. | primary effusion lymphoma (pel) has been recognized as a body-cavity-based lymphoma that was originally reported to be associated with human herpes virus 8 (hhv8) infection, and was frequently found in human immunodeficiency virus-positive (hiv) patients. here we describe an autopsy case of pel of the peritoneal cavity in an immunocompetent patient. cytological analysis of tumor cells within ascites revealed immunocytochemical features of keratin positivity and cd45 negativity. at autopsy, the p ... | 2001 | 11350613 |
| aids-related cancers in the era of highly active antiretroviral therapy. | highly active antiretroviral therapy (haart) has shown great efficacy in reducing human immunodeficiency virus levels, increasing immunity, and prolonging the survival of persons with acquired immunodeficiency syndrome (aids). the risk of life-threatening infections has been greatly reduced. however, the impact of haart on the incidence of malignancy has been less clear. published studies generally show that the risk of developing kaposi's sarcoma declined by about two-thirds between 1994 and 19 ... | 2001 | 11346932 |
| hypoxia induces lytic replication of kaposi sarcoma-associated herpesvirus. | there is substantial evidence that kaposi sarcoma-associated herpesvirus (kshv) plays an important role in the pathogenesis of all forms of kaposi sarcoma (ks). it has been noted that ks commonly occurs in locations, such as the feet, where tissue may be poorly oxygenated. on the basis of this observation, the potential role of hypoxia in the reactivation of kshv replication was explored by studying 2 kshv-infected primary effusion lymphoma b-cell lines (bc-3 and bcbl-1) latently infected with k ... | 2001 | 11342455 |
| primary effusion lymphoma in an hiv-negative patient with no serologic evidence of kaposi's sarcoma virus. | primary effusion lymphoma (pel) is a newly described high-grade b cell lymphoma which develops in association with kaposi's sarcoma-associated herpesvirus (ksv) in human immunodeficiency virus (hiv)-infected individuals. we hereby describe a very unusual presentation of pel that developed in the abdominal cavity of an hiv negative, ksv negative patient with a 1-year history of refractory ascites due to alcohol-related liver cirrhosis. possible factors aiding lymphomagenesis in the cirrhotic stat ... | 2001 | 11342372 |
| hhv-8 elisa based on a one-step affinity capture of biotinylated k8.1 antigen. | the immunogenic envelope antigen gp35-37 of human herpesvirus-8 (hhv-8) is encoded by orfk8.1. an elisa is described using streptavidin capture of bacterially expressed and biotinylated recombinant k8.1 antigen. the antigen capture strategy provides a simple and reliable method, which does not require high yield production and purification of the recombinant antigen before the serological assay. the specificity and sensitivity of the k8.1 elisa were validated by gp35-37 envelope antigen western ... | 2001 | 11337051 |
| signaling by human herpesvirus 8 kaposin a through direct membrane recruitment of cytohesin-1. | the induction of a transformed cellular phenotype by viruses requires the modulation of signaling pathways through viral proteins. we show here that the phenotypic changes induced by the kaposin a protein of human herpesvirus 8 are mediated through its direct interaction with cytohesin-1, a guanine nucleotide exchange factor for arf gtpases and regulator of integrin-mediated cell adhesion. focus formation, stress fiber dissolution, and activation of the erk-1/2 map kinase signal cascade were rev ... | 2001 | 11336706 |
| a review of topical and intralesional cidofovir. | cidofovir is a potent nucleoside analog antiviral drug approved for the treatment of cytomegalovirus (cmv) retinitis in patients with the acquired immune deficiency syndrome (aids). it is currently available only for intravenous infusion. several small studies and case reports describe the successful use of cidofovir applied either topically or by intralesional injection in several virally induced cutaneous diseases. available information demonstrates that cidofovir is a potent antiviral agent w ... | 2000 | 11328613 |
| hhv-8 encoded virf-1 represses the interferon antiviral response by blocking irf-3 recruitment of the cbp/p300 coactivators. | human herpes virus 8 (hhv-8) has developed unique mechanisms for altering cellular proliferative and apoptotic control pathways by incorporating viral homologs to several cellular regulatory genes into its genome. one of the important pirated genes encoded by the orf k9 reading frame is a viral homolog of the interferon regulatory factors (irf), a family of cellular transcription proteins that regulates expression of genes involved in pathogen response, immune modulation and cell proliferation. ... | 2001 | 11314014 |
| detection of kaposi sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. | kaposi sarcoma-associated herpesvirus (kshv) recently has been identified in the bone marrow (bm) dendritic cell of multiple myeloma (mm) patients. however, whether or not kshv is associated with mm remains controversial because many studies have failed to detect the presence of kshv dna sequences in the bm of their mm patients. | 2001 | 11301386 |
| acquired immunodeficiency syndrome-associated cancers in sub-saharan africa. | sub-saharan africa is considered home to more than 60% of all human immunodeficiency virus (hiv) infected cases, with an estimated adult prevalence of 8.0%. it is stated that this region has contributed more than 90% of childhood deaths related to hiv infection and about 93% of childhood acquired immunodeficiency syndrome (aids)-related deaths. although no country in africa is spared of the infection, the bulk is seen in east and south africa, with the highest recorded rates of 20% to 50% in zim ... | 2001 | 11301383 |
| the herpesvirus 8-encoded chemokine vmip-ii, but not the poxvirus-encoded chemokine mc148, inhibits the ccr10 receptor. | the viral chemokine antagonist vmip-ii encoded by human herpesvirus 8 (hhv8) and mc148 encoded by the poxvirus - molluscum contagiosum - were tested against the newly identified chemokine receptor ccr10. as the ccr10 ligand eskine / ccl27 had the highest identity to mc148 and because both chemokines are expressed in the skin we suspected mc148 to block ccr10. however, in calcium mobilization assays we found mc148 unable to block ccr10 in micromolar concentrations in contrast to vmip-ii. (125)i-m ... | 2001 | 11298347 |
| timing of human immunodeficiency virus type 1 and human herpesvirus 8 infections and length of the kaposi's sarcoma-free period in coinfected persons. | 2001 | 11294681 | |
| primary human herpesvirus 8 infection generates a broadly specific cd8(+) t-cell response to viral lytic cycle proteins. | human herpesvirus 8 (hhv-8) is a recently discovered gammaherpesvirus that is the etiologic agent of kaposi sarcoma (ks). the natural history of primary hhv-8 infection, including clinical outcome and host immune responses that may be important in preventing disease related to hhv-8, has not been elucidated. the present study characterized the clinical, immunologic, and virologic parameters of primary hhv-8 infection in 5 cases detected during a 15-year longitudinal study of 108 human immunodefi ... | 2001 | 11290599 |
| human herpesvirus 8 interaction with target cells involves heparan sulfate. | human herpesvirus 8 (hhv-8) or kaposi's sarcoma associated herpesvirus (kshv) is associated with kaposi's sarcoma and primary effusion lymphoma. in vivo, hhv-8 dna and transcripts have been detected in b cells, endothelial cells, macrophages, and epithelial cells. hhv-8 infects a variety of cell lines of human and animal origin, leading to latent or abortive infection. this study shows that the broad cellular tropism of hhv-8 may be in part due to its interaction with the ubiquitous host cell su ... | 2001 | 11289807 |
| the kaposi's sarcoma-associated herpesvirus g protein-coupled receptor promotes endothelial cell survival through the activation of akt/protein kinase b. | the kaposi's sarcoma-associated herpesvirus g protein-coupled receptor (kshv-gpcr) is a key molecule in the pathogenesis of kaposi's sarcoma, playing a central role in the promotion of vascular endothelial growth factor (vegf)-driven angiogenesis and spindle cell proliferation. we previously have shown that kshv-gpcr has oncogenic potential when overexpressed in fibroblasts and is responsible for the expression and secretion of vegf through the regulation of different intracellular signaling pat ... | 2001 | 11289142 |
| primary kaposi sarcoma of the bowel in a hiv-negative patient. | a case of kaposi sarcoma with hiv-negative and sequence of hhv-8 positive and exclusive rectosigmoid and descending colon involvement without immunodeficiency is reported. histologically, in addition to typical features of kaposi sarcoma, cowdry type a inclusions were seen. pcr analysis of the tumor showed positivity for human herpesvirus 8. two of the six reported cases of kaposi sarcoma limited to the bowel were from african men before the aids epidemic. j. surg. oncol. 2001;76:197-200. | 2001 | 11276024 |
| human herpes virus-8 infection among pregnant women and their children: results from the sardinia-iddm study 2. | 2001 | 11267990 | |
| kaposi's sarcoma-associated herpesvirus k-bzip protein is phosphorylated by cyclin-dependent kinases. | the k8 locus in kaposi's sarcoma-associated herpesvirus (kshv) is syntenic with the epstein-barr virus (ebv) bzlf (z) locus and expresses three alternatively spliced transcripts. the fully spliced transcript encodes k-bzip, the kshv homologue of the ebv immediate-early transcriptional transactivator z. here we show that despite the presence of alternatively spliced transcripts, the protein from the fully spliced rna, k-bzip, is the principal product detectable in kshv-infected b cells. the prote ... | 2001 | 11238844 |
| biological features of the clone involved in primary amyloidosis (al). | primary light chain-associated amyloidosis (al) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). it is the most common form of systemic amyloidosis in western countries and is rapidly fatal. knowledge of the pathobiology of the underlying b cell clone is of primary importance for the design and optimization of therapeutic strategies. | 2001 | 11236934 |
| prevalence of kaposi sarcoma-associated herpesvirus compared with selected sexually transmitted diseases in adolescents and young adults in rural rakai district, uganda. | kaposi sarcoma-associated herpesvirus (kshv) is transmitted by routes such as homosexual intercourse and is associated with hiv infection in industrialized countries. however, there is little information about its transmission in developing countries where kaposi sarcoma is an endemic disease. | 2001 | 11234789 |
| mucosal shedding of human herpesvirus 8. | 2001 | 11229345 | |
| polymerase chain reaction detection of kaposi's sarcoma-associated herpesvirus-optimized protocols and their application to myeloma. | since its discovery in 1994, kshv (also called human herpesvirus-8 or hhv8) has been implicated in a variety of disorders. although the association of kshv with kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease has been well established, its presence in some other diseases, such as multiple myeloma, remains controversial. because most kshv studies are based on polymerase chain reaction (pcr) analysis, the conflicting data may be attributable to variatio ... | 2001 | 11227070 |
| internal ribosome entry site regulates translation of kaposi's sarcoma-associated herpesvirus flice inhibitory protein. | the gammaherpesvirus kaposi's sarcoma-associated herpesvirus (kshv) (or human herpesvirus 8) is associated with the endothelial tumor kaposi's sarcoma (ks) and lymphoproliferative disorders in immunocompromised individuals. only a small number of viral proteins are expressed in b cells latently infected with kshv; here we characterize the mechanism of expression of one of these, the viral flice inhibitory protein v-flip (k13, orf71). the v-flip coding region is present in a bicistronic message, ... | 2001 | 11222719 |
| intrafamilial transmission of human herpesvirus 8. | 2001 | 11208891 | |
| [primary effusion lymphoma and other lymphoproliferative diseases associated with hhv-8]. | 2000 | 11198465 | |
| the biology of kaposi's sarcoma. | 2001 | 11191137 | |
| non-hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment. | 2001 | 11191128 | |
| biology of non-hodgkin's lymphoma. | 2001 | 11191126 | |
| treatment of kaposi's sarcoma. | 2001 | 11191125 | |
| viral exploitation and subversion of the immune system through chemokine mimicry. | the chemokine superfamily of leukocyte chemoattractants coordinates development and deployment of the immune system by signaling through a family of g protein-coupled receptors. the importance of this system to antimicrobial host defense has been supported by the discovery of numerous herpesviruses and poxviruses that encode chemokine mimics able to block chemokine action. however, specific herpesviruses and lentiviruses can also exploit the immune system through chemokine mimicry, for example, ... | 2001 | 11175803 |
| colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of kaposi's sarcoma and lymphoid cells of multicentric castleman's disease. | human herpesvirus-8 (hhv-8) also called kaposi's sarcoma-associated herpesvirus infects spindle cells in kaposi's sarcoma (ks) and lymphoid cells in multicentric castleman's disease (mcd). in ks cells, hhv-8 is mainly latent with the expression of latent nuclear antigen-1 (lna-1), whereas in mcd both lytic and latent antigens are produced by lymphoid cells. we show by immunohistochemical labeling that in ks viral interleukin-6 (vil-6) is expressed in rare spindle cells, whereas in mcd, vil-6 is ... | 2001 | 11172301 |
| identification of a short amino acid sequence essential for efficient nuclear targeting of the kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 k8 protein. | the k8 protein of kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus-8 is a member of the bzip family of transcription factors, which has homology with the epstein-barr virus transcription and replication factor, eb1. in this report, we have analysed the subcellular localization of the k8 protein and characterized a 12 amino acid sequence rich in basic residues which is responsible for targeting the protein to the cell nucleus. furthermore, we show that a k8 mutant lacking the nucl ... | 2001 | 11172091 |
| human herpesviruses-6, -7 and -8 in organ transplant recipients. | the newer herpesviruses are being increasingly recognized as significant opportunistic pathogens in organ transplant recipients. published data support the role of human herpesvirus-6 as a potential cause of encephalitis and bone marrow suppression in transplant setting. an association of human herpesvirus-6 with fungal infections and cytomegalovirus infection has also been documented. human herpesvirus-7 also appears to be an immunomodulatory agent and may facilitate the pathogenicity of cytome ... | 2000 | 11168178 |
| b-lymphotropic viruses in a novel tropical splenic lymphoma. | peripheral blood from patients with a novel tropical splenic lymphoma, characterized by splenomegaly and circulating naïve cd5-negative villous b lymphocytes, has been screened for evidence of an association with the b-lymphotropic viruses, epstein--barr virus (ebv), hepatitis c virus (hcv) and human herpesvirus 8 (hhv8). no increased prevalence of ebv, hcv and hhv8 was demonstrated using serological and molecular techniques, compared with a geographical, age-matched control group. however, lymp ... | 2001 | 11167797 |
| kaposi's sarcoma, oncogenic viruses, and iron. | iron is required for many cellular processes, but it is also toxic in excess quantities. therefore, iron homeostasis and utilization must be strictly maintained, and defects in iron absorption or transport result in iron depletion or accumulation. most research has been directed to enteral and placental transfer of iron, but little is known about iron entry through the skin. we present evidence that exposure to wet clay soils in africa is an important risk factor for kaposi's sarcoma (ks) and sp ... | 2001 | 11166660 |
| structure/function of human herpesvirus-8 mip-ii (1-71) and the antagonist n-terminal segment (1-10). | kaposi's sarcoma-associated herpesvirus encodes a chemokine called vmip-ii that has been shown to be a broad range human chemokine receptor antagonist. two n-terminal peptides, vmip-ii(1-10) and vmip-ii(1-11)dimer (dimerised through cys11) were synthesised. both peptides are shown to bind the cxc chemokine receptor 4 (cxcr4). vmip-ii(1-10) was 1400-fold less potent than the native protein whilst the vmip-ii(1-11)dimer was only 180-fold less potent. in addition, both peptides are cxcr4 antagonist ... | 2001 | 11165244 |
| kaposi's sarcoma-associated herpesvirus vcyclin open reading frame contains an internal ribosome entry site. | we have previously examined the transcription and splicing of open reading frames (orfs) 71 (k13), 72, and 73 of kaposi's sarcoma-associated herpesvirus (kshv) in the primary effusion lymphoma cell line bcp-1 (latently infected with kshv) (45). the three genes encoded by these orfs (for vflip, vcyclin, and latency-associated nuclear antigen [lana]) are transcribed from a common transcription start site in bcp-1 cells during both latency and the lytic cycles. the resulting transcript is spliced t ... | 2001 | 11160685 |
| mechanisms governing expression of the v-flip gene of kaposi's sarcoma-associated herpesvirus. | open reading frame 71 (orf 71) of kaposi's sarcoma-associated herpesvirus (kshv) encodes a death effector domain-containing protein that is homologous to cellular flips (flice-inhibitory proteins) and is proposed to inhibit fas-mediated apoptosis. transcripts bearing orf 71 (v-flip) sequences are present in all latently infected cells. however, mapping studies reveal these to be bi- or tricistronic mrnas with orf 71 located 3' to orfs 72 (v-cyclin) and 73 (latency-associated nuclear antigen), ra ... | 2001 | 11160684 |
| role of the national cancer institute in acquired immunodeficiency syndrome-related drug discovery. | 2001 | 11158208 | |
| post-transplant lymphoproliferative disorders: implications for acquired immunodeficiency syndrome-associated malignancies. | post-transplant lymphoproliferative disorders (ptlds) comprise a histologic spectrum, ranging from hyperplastic-appearing lesions to frank non-hodgkin's lymphoma or multiple myeloma histology. multiple clones may coexist, each representing a discrete lymphomagenic event, a situation that is unique to immunodeficiency states. the incidence varies from 1% in renal recipients to 5% in heart recipients, but can be markedly increased by the use of anti-t-cell therapies or by t-cell depletion in bone ... | 2001 | 11158205 |
| kaposi's sarcoma in south africa. | kaposi's sarcoma was endemic in south africa even before the advent of the human immunodeficiency virus (hiv). between 1988 and 1996, the incidence of kaposi's sarcoma in south africa has risen at least threefold and continues to increase as the hiv epidemic grows. research from south africa has shown that infection with human herpesvirus 8 (hhv8) is associated with kaposi's sarcoma but not with any other major cancer site or type. in addition, the risk of kaposi's sarcoma increases with increas ... | 2001 | 11158199 |
| detection of lymphotropic herpesvirus dna by polymerase chain reaction in cerebrospinal fluid of aids patients with neurological disease. | cerebrospinal fluid (csf) samples from 49 acquired immunodefficiency disease syndrome (aids) patients with a central nervous system (cns) disease were examined by polymerase chain reaction (pcr) to evaluate the association between the positivity for cytomegalovirus (cmv) and epstein-barr virus (ebv), and clinical diagnosis of a cns disease. frequency and clinical relevance of detection of dna of human herpesviruses 6 (hhv-6), 7 (hhv-7) and 8 (hhv-8) were also determined. dna of one or more of th ... | 2000 | 11155355 |
| activation of kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. | the majority of kaposi's sarcoma-associated herpesvirus (kshv)-infected cells identified in vivo contain latent kshv, with lytic replication in only a few percent of cells, as is the case for the cells of kaposi's sarcoma (ks) lesions. factors that influence kshv latent or lytic replication are not well defined. because persons with ks are often immunosuppressed and susceptible to many infectious agents, including human cytomegalovirus (hcmv), we have investigated the potential for hcmv to influ ... | 2001 | 11152511 |