Publications

study on the interactions of trans-resveratrol and curcumin with bovine α-lactalbumin by spectroscopic analysis and molecular docking.	the ability of bovine α-lactalbumin (bla) as a whey protein to carry curcumin and trans-resveratrol as two natural polyphenolic compounds was investigated by fluorescence quenching measurements and docking studies. curcumin is the bioactive component of turmeric and trans-resveratrol is abundant in different types of fruits and vegetables. the binding parameters such as binding constants and the number of substantive binding sites have been estimated from the analysis of fluorescence quenching m ...	2015	25746281
anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin.	turmeric is obtained from the plant curcuma longa l; its major constituent, curcumin, is a polyphenol with multiple effects which can modulate some signaling pathways.	2014	25745485
anti-oxidative effect of turmeric on frying characteristics of soybean oil.	curcumin, the active principle of turmeric, is known to act as an anti-oxidant, anti-mutagen and anti-carcinogen. this study aimed to find out the thermal and oxidative stability of soybean oil when potatoes marinated with turmeric were deep fried in the oil. two sets of experiment were carried out. in one set, 1 l of oil was heated for 24 h (8 h daily for 3 consecutive days) and 200 g of potato chips without any marination were fried each time twice daily. foods were fried in batches to replica ...	2015	25745253
evaluation of antibacterial activity of some traditionally used medicinal plants against human pathogenic bacteria.	the worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. we aimed to find the in vitro antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method. the evaluated plants species were found to exert a range of in vitro ...	2015	25738151
effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma a375 cells.	malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. curcumin is extracted from curcuma longa l.; curcumin has anti-tumor efficacy in multiple systemic malignancies. here, we investigated the effect of curcumin on a375 human melanoma cells. a375 cells were cultivated, passaged, and treated with different concentrations of curcumin. we observed the cellular morphology and determined the migration, invasion, proliferation, and apoptosis of a375 cells in vitro ...	2015	25730045
plant-derived natural medicines for the management of depression: an overview of mechanisms of action.	depression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. the aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. for this purpose, electronic databases, including pubmed, science direct, ...	2015	25719303
curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin.	although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (nsclc), it has limited therapeutic efficacy due to activation of a survival signaling pathway and the induction of multidrug resistance. curcumin, a natural compound isolated from the plant curcuma longa, is known to sensitize tumors to different chemotherapeutic agents. the aim of this study is to evaluate whether curcumin can chemosensitize lung cancer cells to carboplatin and to analyze the sig ...	2015	25716014
tissue-specific metabolite profiling of turmeric by using laser micro-dissection, ultra-high performance liquid chromatography-quadrupole time of fight-mass spectrometry and liquid chromatography-tandem mass spectrometry.	curcuma longa l. is recognized for its therapeutic and culinary uses both in ayurveda and traditional chinese medicine and is considered to be a boon to mankind. it has been extensively studied for its benefits and still continues to be an important drug with continued potential for further exploration and research. we studied the tissue-specific distribution of secondary metabolites to establish the validity of the use of rhizome samples from india and china, as substitutes for each other, base ...	2014	25707128
elucidation of the inhibitory effect of phytochemicals with kir6.2 wild-type and mutant models associated in type-1 diabetes through molecular docking approach.	among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. but, there is still a gap in deciding on the choice of a drug, especially when the target is mutated. mutations in the kcnj11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 d ...	2014	25705171
curcumin conjugated with plga potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells.	curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. it is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. therefore, enhancing the b ...	2015	25692854
spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration.	there is a growing interest in the therapeutic utility of compounds derived from curcuma longa, an herb of the zingiberaceae family that has been part of traditional medicine for centuries. recent reports suggest that bioactive compounds isolated from the rhizome of these plants can address two key aspects of brain injury following stroke that must be dealt with for functional recovery to occur: the moderation of neuroinflammation, and the mobilization of endogenous stem cells resident in the ne ...	2014	25688994
mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial.	oxidative stress is implicated in the pathogenesis of osteoarthritis. curcuminoids are natural polyphenols with strong antioxidant capacity and may thus be helpful in the treatment of osteoarthritis. the present randomized double-blind placebo-controlled trial investigated the efficacy of curcuminoids in reducing systemic oxidative burden in patients suffering from knee osteoarthritis. forty patients with mild-to-moderate primary knee osteoarthritis were given curcuminoid capsules (1500 mg/day i ...	2016	25688638
curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes.	primary percutaneous coronary intervention, or thombolytic therapy, provides effective myocardial blood reconstruction in patients with acute myocardial infarction to reduce acute myocardial ischemic injury. however, reperfusion can itself induce cardiomyocyte death, termed myocardial reperfusion injury (i/r). hypoxia/reoxygenation (h/r) induces apoptosis and excessive autophagy among cardiomyocytes, leading to cell death. the present study investigated the effect of curcumin, a natural extract ...	2015	25673156
potential anticancer properties and mechanisms of action of curcumin.	curcumin, a yellow substance belonging to the polyphenols superfamily, is the active component of turmeric, a common indian spice, which is derived from the dried rhizome of the curcuma longa plant. numerous studies have demonstrated that curcumin possesses anti-oxidant, anti-inflammatory and anticancerous properties. the purpose of this review is to focus on the anti-tumor effects of curcumin. curcumin inhibits the stat3 and nf-κb signaling pathways, which play key-roles in cancer development a ...	2015	25667441
the multifaceted role of curcumin in cancer prevention and treatment.	despite significant advances in treatment modalities over the last decade, neither the incidence of the disease nor the mortality due to cancer has altered in the last thirty years. available anti-cancer drugs exhibit limited efficacy, associated with severe side effects, and are also expensive. thus identification of pharmacological agents that do not have these disadvantages is required. curcumin, a polyphenolic compound derived from turmeric (curcumin longa), is one such agent that has been e ...	2015	25665066
application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria.	curcumin, a yellow pigment derived from the rhizomes of curcuma longa linn, is a natural antioxidant that exhibits a variety of pharmacological activities and therapeutic properties. however, as curcumin is generally conjugated when absorbed through the intestine, free curcumin is present at extremely low levels in the body. thus, curcumin metabolites are presumed to be responsible for curcumin bioactivity. in this study, we describe a strategy using ultra-performance liquid chromatography/quadr ...	2015	25658514
natural occurrence of aflatoxins and ochratoxin a in processed spices marketed in malaysia.	the analysis of aflatoxins (b1, b2, g1 and g2) and ochratoxin a (ota) was performed in processed spices marketed in penang, malaysia, using immunoaffinity columns and hplc equipped with fluorescence detector (hplc-fd). the processed powdered spices analysed include dried chilli, fennel, cumin, turmeric, black and white pepper, poppy seed, coriander, 'garam masala', and mixed spices for fish, meat and chicken curry. two different studies were carried out. the limit of detection (lod) was 0.01 ng ...	2015	25658149
evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of zingiberaceae family against b164a5 murine melanoma cells.	curcuma longa linnaeus and zingiber officinale roscoe are two main representatives of zingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human immunodeficiency virus properties and anticancer effects. this study was aimed to analyse the ethanolic extracts of curcuma rhizome (curcuma longa linnaeus) and zingiber rhizome (zingiber officinale roscoe) in te ...	2015	25654588
effect of oral curcuma gel in gingivitis management - a pilot study.	various modalities of treatments are available for gingival disease, but there are adverse effects of these conventional compounds. this led to the search of natural products which are highly beneficial and biocompatible. turmeric is one such novel product obtained from plants, known for its varied medicinal value. in dentistry, it plays a role treating gingival and periodontal disease.	2014	25654020
effect of curcumin supplementation on physiological fatigue and physical performance in mice.	curcumin (ccm) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. however, few studies have examined its effects on exercise performance and physical fatigue. we aimed to evaluate the potential beneficial effects of ccm supplementation on fatigue and ergogenic function following physical challenge in mice. male icr mice were divided into four groups to receive vehicle or ccm (180 μg/ml) by oral gavage at 0, 12.3, 24.6, or 61.5 ml/k ...	2015	25647661
involvement of ros-p38-h2ax axis in novel curcumin analogues-induced apoptosis in breast cancer cells.	curcumin-based structural modification for developing more effective curcumin analogues has been drawning increasing attention. as alternative approach, using lc/ms guided purification, we previously obtained a series of novel natural terpene-conjugated curcuminoids from turmeric, and some of them exhibited even more potent anti-cancer activity against multiple types of cancer cells than curcumin. the purpose of this follow-up study was designed to decipher the mechanisms involved in anti-cancer ...	2016	25647442
curcumin suppresses the production of pro-inflammatory cytokine interleukin-18 in lipopolysaccharide stimulated murine macrophage-like cells.	curcumin is a major bioactive compound of turmeric that exerts its anti-inflammatory effects by suppressing the many pro-inflammatory cytokines and chemokines in a number of cell types and pathologic conditions. interleukin-18 (il-18) is a novel pro-inflammatory cytokine which plays an important role not only in generating th1 responses but also in inducing severe inflammatory reactions. as curcumin induced inhibition of il-18 production in keratinocytes and mice is well known, effect of curcumi ...	2015	25646051
production of curcuminoids from tyrosine by a metabolically engineered escherichia coli using caffeic acid as an intermediate.	curcuminoids are phenylpropanoids with high pharmaceutical potential. herein, we report an engineered artificial pathway in escherichia coli to produce natural curcuminoids through caffeic acid. arabidopsis thaliana 4-coumaroyl-coa ligase and curcuma longa diketide-coa synthase (dcs) and curcumin synthase (curs1) were used to produce curcuminoids and 70 mg/l of curcumin was obtained from ferulic acid. bisdemethoxycurcumin and demethoxycurcumin were also produced, but in lower concentrations, by ...	2015	25641677
curcumin inhibits anchorage-independent growth of ht29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene dlec1.	colorectal cancer remains the most prevalent malignancy in humans. the impact of epigenetic alterations on the development of this complex disease is now being recognized. the dynamic and reversible nature of epigenetic modifications makes them a promising target in colorectal cancer chemoprevention and treatment. curcumin (cur), the major component in curcuma longa, has been shown as a potent chemopreventive phytochemical that modulates various signaling pathways. deleted in lung and esophageal ...	2015	25640947
effect of curcumin on hepatic antioxidant enzymes activities and gene expressions in rats intoxicated with aflatoxin b1.	twenty-eight rats were examined in a 5-week experiment to investigate the effect of curcumin on gene expression and activities of hepatic antioxidant enzymes in rats intoxicated with aflatoxin b1 (afb1 ). the rats were divided into four groups. rats in 1-4 groups served as control, oral curcumin treated (15 mg/kg body weight), single i.p. dose of afb1 (3 mg/kg body weight) and combination of single i.p. dose of afb1 with oral curcumin treated, respectively. afb1 liver damage and oxidative stress ...	2015	25639897
utilizing food matrix effects to enhance nutraceutical bioavailability: increase of curcumin bioaccessibility using excipient emulsions.	excipient foods have compositions and structures specifically designed to improve the bioaccessibility of bioactive agents present in other foods coingested with them. in this study, an excipient emulsion was shown to improve the solubility and bioaccessibility of curcumin from powdered rhizome turmeric (curcuma longa). corn oil-in-water emulsions were mixed with curcumin powder, and the resulting mixtures were incubated at either 30 °c (to simulate a salad dressing) or 100 °c (to simulate a coo ...	2015	25639191
targeted integration of rna-seq and metabolite data to elucidate curcuminoid biosynthesis in four curcuma species.	curcuminoids, namely curcumin and its analogs, are secondary metabolites that act as the primary active constituents of turmeric (curcuma longa). the contents of these curcuminoids vary among species in the genus curcuma. for this reason, we compared two wild strains and two cultivars to understand the differences in the synthesis of curcuminoids. because the fluxes of metabolic reactions depend on the amounts of their substrate and the activity of the catalysts, we analyzed the metabolite conce ...	2015	25637373
effects of three kinds of curcuminoids on anti-oxidative system and membrane deformation of human peripheral blood erythrocytes in high glucose levels.	curcuminoids are the main bioactive constituents of the rhizome of turmeric. erythrocytes lesions in diabetes are probably related to hyperglycemia and protein glycation. it has been reported that curcumin prevent lipid peroxidation. however, reports on the effects of demethoxycurcumin and bis-demethoxycurcumin on human erythrocytes at high glucose levels are scarce. our aim is to investigate the effect of curcuminoids on oxidative stress and membrane of erythrocytes exposed to hyperglycemic con ...	2015	25634758
effect of a natural supplement containing curcuma longa, guggul, and chlorogenic acid in patients with metabolic syndrome.	the impact of a natural supplement (kepar; rikrea, italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (mets; 45 men; age: 62 ± 9 years). kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at base ...	2015	25632052
heterologous production of curcuminoids.	curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. therefore, they represent attractive targets for heterologous production and metabolic engineering. the understanding of biosynthesis of curcumin ...	2015	25631288
sodium metabisulphite, a preservative agent, decreases the heart capillary volume and length, and curcumin, the main component of curcuma longa, cannot protect it.	sodium metabisulphite is used as an antioxidant agent in many pharmaceutical formulations. it is extensively used as a food preservative and disinfectant. it has been demonstrated that sulphite exposure can affect some organs. curcumin, the main element of curcuma longa, has been identified to have multiple protective properties. the present study extends the earlier works to quantitative evaluation of the effects of sulphite and curcumin on the heart structure using stereological methods. in th ...	2014	25629268
the effect of turmeric (curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling.	endurance exercise induces il-6 production from myocytes that is thought to impair intracellular defence mechanisms. curcumin inhibits nf-κb and activator protein 1, responsible for cytokine transcription, in cell lines. the aim of this study was to investigate the effect of curcumin supplementation on the cytokine and stress responses following 2 h of cycling.	2015	25628521
thermal stability, antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl guaiacol.	curcumin is a secondary plant metabolite present in curcuma longa l. since curcumin is widely used as a food colorant in thermally processed food it may undergo substantial chemical changes which in turn could affect its biological activity. in the current study, curcumin was roasted at 180 °c up to 70 minutes and its kinetic of degradation was analyzed by means of hplc-pda and lc-ms, respectively. roasting of curcumin resulted in the formation of the degradation products vanillin, ferulic acid, ...	2015	25619943
antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis.	oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (mets). curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties.	2015	25618800
curcumin treatment suppresses ccr7 expression and the differentiation and migration of human circulating fibrocytes.	recent studies have demonstrated that circulating fibrocytes contribute to the formation and development of fibrosis. curcumin, a polyphenolic compound isolated from turmeric, has been shown to have anti-fibrotic effects in various organs. we and others have demonstrated that curcumin beneficially affects the development of fibrosis. however the effect of curcumin on circulating fibrocytes has not been reported.	2015	25613752
salinity alters curcumin, essential oil and chlorophyll of turmeric (curcuma longa l.).	turmeric (curcuma longa l.) is a perennial rhizomatous plant from the family of zingibraceae, native in south asia. the main components of turmeric are curcuminoids and essential oil which are responsible for turmeric characteristic such as odor and taste. due to the large areas of saline land in iran and less information related to cultivation of turmeric, in this research, the effect of salinity on growth, curcumin and essential oil of turmeric was evaluated. rhizomes were planted in coco peat ...	2017	25598799
curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis.	curcumin is a naturally occurring polyphenol present in the roots of the curcuma longa plant (turmeric), which possesses antioxidant, antitumorigenic, and antiinflammatory properties. here, we test whether curcumin treatment reduces high glucose-induced neural tube defects (ntds), and if this occurs via blocking cellular stress and caspase activation.	2015	25595578
demethoxycurcumin modulates human p-glycoprotein function via uncompetitive inhibition of atpase hydrolysis activity.	curcuminoids are major components of curcuma longa l., which is widely used as spice in food. this study aimed at identifying whether curcumin, demethoxycurcumin, and bisdemethoxycurcumin could modulate efflux function of human p-glycoprotein and be used as chemosensitizers in cancer treatments. without altering p-glycoprotein expression levels and conformation, the purified curcuminoids significantly inhibited p-glycoprotein efflux function. in rhodamine 123 efflux and calcein-am accumulation a ...	2015	25594233
effect of some high consumption spices on hemoglobin glycation.	formation of glycation products is major factor responsible in complications of diabetes. worldwide trend is toward the use of natural additives in reducing the complications of diseases. therefore, there is a growing interest in natural antiglycation found in plants. herbs and spices are one of the most important targets to search for natural antiglycation from the point of view of safety. this study investigated the ability of some of the spices to inhibit glycation process in a hemoglobin/glu ...	2017	25593391
effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments.	data suggest that culinary spices are a potent, low-calorie modality for improving physiological responses to high fat meals. in a pilot study (n = 6 healthy adults), we showed that a meal containing a high antioxidant spice blend attenuated postprandial lipemia by 30% compared to a low spice meal. our goal was to confirm this effect in a larger sample and to consider the influence of acute psychological stress on fat metabolism. further, we used in vitro methods to evaluate the inhibitory effec ...	2015	25592751
magnetic purification of curcumin from curcuma longa rhizome by novel naked maghemite nanoparticles.	naked maghemite nanoparticles, namely, surface active maghemite nanoparticles (samns), characterized by a diameter of about 10 nm, possessing peculiar colloidal stability, surface chemistry, and superparamagnetism, present fundamental requisites for the development of effective magnetic purification processes for biomolecules in complex matrices. polyphenolic molecules presenting functionalities with different proclivities toward iron chelation were studied as probes for testing samn suitability ...	2015	25584520
turmeric and black pepper spices decrease lipid peroxidation in meat patties during cooking.	spices are rich in natural antioxidants and have been shown to be potent inhibitors of lipid peroxidation during cooking of meat. turmeric contains unique conjugated curcuminoids with strong antioxidant activity. piperine, one of the main constituents of black pepper, is known to increase the bioavailability of curcuminoids in mouse and human studies when consumed with turmeric. we investigated whether adding black pepper to turmeric powder may further inhibit lipid peroxidation when added to me ...	2015	25582173
quality and safety of herbal medical products: regulation and the need for quality assurance along the value chains.	herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. as importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiversity rich countries with the large markets in the north. this paper discusses the current regulatory framework of such herbal medical products (with a focus on the uk) and using e ...	2015	25581270
assessing intake of spices by pattern of spice use, frequency of consumption and portion size of spices consumed from routinely prepared dishes in southern india.	measurement of dietary intake of spices is gaining significance because of recognition of their health promoting benefits as well as its use for risk assessment of contaminant exposures. estimating intake of spices at the individual level, presents several challenges since various spices are used as an integrated part of a prepared food and consumed in amounts much smaller than other dietary components. the objective of the present study is to assess intake of spices at the household and individ ...	2015	25577292
anti-platelet activity of water dispersible curcuminoids in rat platelets.	curcuminoids are active principle of turmeric with plethora of health beneficial properties. in this study, we have evaluated for the first time the effect of water dispersible curcuminoids on rat platelet aggregation. curcuminoids (10-30 µg/ml) significantly inhibited platelet aggregation induced by agonists viz., collagen, adp and arachidonic acid. curcuminoids were found to be two-fold more potent than curcumin in inhibiting platelet aggregation. intracellular curcuminoid concentration was re ...	2015	25572959
farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer.	a huge number of compounds are widely distributed in nature and many of these possess medicinal/biological/pharmacological activity. curcumin, a polyphenol derived from the rhizomes (underground stems) of curcuma longa linn (a member of the ginger family, commonly known as turmeric) is a culinary spice and therapeutic used in india for thousands of years to induce color and flavor in food as well as to treat a wide array of diseases. the origin of turmeric as spice and folklore medicine is so ol ...	2014	25566531
actin-curcumin interaction: insights into the mechanism of actin polymerization inhibition.	curcumin, derived from rhizomes of the curcuma longa plant, is known to possess a wide range of medicinal properties. we have examined the interaction of curcumin with actin and determined their binding and thermodynamic parameters using isothermal titration calorimetry. curcumin is weakly fluorescent in aqueous solution, and binding to actin enhances fluorescence several fold with a large blue shift in the emission maximum. curcumin inhibits microfilament formation, which is similar to its role ...	2015	25564154
curcumin as an adjuvant to breast cancer treatment.	cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing cause of mortality among all cases of malignant neoplastic disease in adult females. the incidence rate of breast malignant neoplastic disease is predominantly higher in western women, when compared to women in asian nations. the definitive reason for this conflict is even unknown, but dietary factors have been conceived to account for approximately 30% of cancers in western nations. it has bee ...	2015	25553436
effects of zedoary turmeric oil on p450 activities in rats with liver cirrhosis induced by thioacetamide.	the aim of this study was to elucidate the effects of zedoary turmeric oil (zto) on p450 activities (cyp1a2, cyp2c9, cyp2c19, cyp2b6, cyp2d6 and cyp3a4) in rats with liver cirrhosis induced by thioacetamide (taa). for the induction of liver cirrhosis, rats were given taa in their drinking water at a concentration of 0.03% for consecutive 5 weeks and then 0.04% for the next consecutive 5 weeks throughout the establishment of cirrhosis. then the cirrhotic rats were ip given saline, zto 100, 200 an ...	2014	25550825
curcumin boosts dha in the brain: implications for the prevention of anxiety disorders.	dietary deficiency of docosahexaenoic acid (c22:6 n-3; dha) is linked to the neuropathology of several cognitive disorders, including anxiety. dha, which is essential for brain development and protection, is primarily obtained through the diet or synthesized from dietary precursors, however the conversion efficiency is low. curcumin (diferuloylmethane), which is a principal component of the spice turmeric, complements the action of dha in the brain, and this study was performed to determine mole ...	2015	25550171
barcoding melting curve analysis for rapid, sensitive, and discriminating authentication of saffron (crocus sativus l.) from its adulterants.	saffron (crocus sativus l.) is one of the most important and expensive medicinal spice products in the world. because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as carthamus tinctorius l. and calendula officinalis l. flowers, hemerocallis l. petals, daucus carota l. fleshy root, curcuma longa l. rhizomes, zea may l., and nelumbo nucifera gaertn. stigmas. to develop a straightforward, nonsequencing method for rapid, ...	2014	25548775
curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.	curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin. one of the major metabolites of curcumin is tetrahydrocurcumin (thc), which lacks α,β-unsaturated carbonyl moiety and is white in color. whether thc is superior to curcumin ...	2014	25547723
ethnopharmacological assessment of medicinal plants used against livestock infections by the people living around indus river.	the present study was aimed to document detailed ethnopharmacological knowledge of medicinal plants against livestock infections of an unexplored remote region of pakistan. semistructured questionnaires were used for data collection. total 43 plants belonging to 26 families were found to be used in ethnoveterinary practices. seeds (29%) were found to be the most frequent plant part used followed by leaves (22%). ethnoveterinary recipes were mostly prepared in the form of decoction and powdering. ...	2014	25544941
anticancer potential and mechanism of action of mango ginger (curcuma amada roxb.) supercritical co₂ extract in human glioblastoma cells.	mango ginger (curcuma amada roxb.) is among the less-investigated species of curcuma for anticancer properties. we have investigated the anticancer potential and the mechanism of action of a supercritical co2 extract of mango ginger (ca) in the u-87mg human glioblastoma cell line. ca demonstrated higher cytotoxicity than temozolomide, etoposide, curcumin, and turmeric force with ic50, ic75, and ic90 values of 4.92 μg/ml, 12.87 μg/ml, and 21.30 μg/ml, respectively. inhibitory concentration values ...	2015	25542408
inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell.	numerous epidemiological studies have suggested effectiveness of long-term and regular use of non-steroidal anti-inflammatory drugs (nsaids), such as ibuprofen and aspirin, in preventing and treatment of certain cancers including prostate, colon, breast, lung, and gastric cancers. we have studied the potential anti-turmeric effect of ibuprofen in adenocarcinoma gastric cell line (ags). the effects of ibuprofen were investigated on cell proliferation, apoptosis, angiogenesis, and expression of st ...	2015	25542229
curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--carbonyl reductase 1.	curcumin is a major component of the plant curcuma longa l. it is traditionally used as a spice and coloring in foods and is an important ingredient in curry. curcuminoids have anti-oxidant and anti-inflammatory properties and gained increasing attention as potential neuroprotective and cancer preventive compounds. in the present study, we report that curcumin is a potent tight-binding inhibitor of human carbonyl reductase 1 (cbr1, ki=223 nm). curcumin acts as a non-competitive inhibitor with re ...	2015	25541467
curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo.	nonalcoholic steatohepatitis (nash) is the advanced form of nonalcoholic fatty liver disease, which is often accompanied by obese and/or type ii diabetes mellitus. approximately one-third of nash patients develop hepatic fibrosis. hepatic stellate cells are the major effector cells during liver fibrogenesis. advanced liver fibrosis usually proceeds to cirrhosis and even hepatocellular carcinoma, leading to liver failure, portal hypertension and even death. currently, there are no approved agents ...	2015	25532502
simple analytical strategy for maldi-tof-ms and nanouplc-ms/ms: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ros protein indicators reduced by curcumin.	curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. curcumin is a potent substance with several functions, including antioxidant, antitumor, anti-inflammatory, antimicrobial, antiparasitic, antimutagenic, chemopreventive and chemotherapeutic activities. matrix-assisted laser desorption/ionisation coupled with time-of-flight mass spectrometry (maldi-tof-ms) has been used to analyse various molecules (including natural antioxida ...	2015	25529721
intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice.	lipopolysaccharide (lps) is one of the most powerful proinflammatory factor and can induce acute pulmonary inflammation even lung injury after inhalation or systemic administration. lps induces sepsis and multiple organ damage. curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against lps-induced acute lung injury (ali). we aimed to investigate effects of intranasal curcumin on lps-induced ali in mice where curcumin (10 mg/kg, intranasal (i.n.) was given an hour be ...	2015	25526714
β-d-glucan nanoparticle pre-treatment induce resistance against pythium aphanidermatum infection in turmeric.	in vitro experiments were carried out to test the efficacy of gnp (β-d-glucan nanoparticle prepared from mycelium of pythium aphanidermatum) against rhizome rot disease of turmeric (curcuma longa l.) caused by p. aphanidermatum. gnp (0.1%, w/v) was applied to rhizome prior to inoculation with p. aphanidermatum (0 h, 24 h). cell death, activities of defense enzymes such as peroxidase, polyphenol oxidase, protease inhibitor and β-1,3 glucanase were monitored. prior application of gnp (24 h) to tur ...	2015	25524742
mitogen-activated protein kinase hog1 is activated in response to curcumin exposure in the budding yeast saccharomyces cerevisiae.	curcumin (cur), an active polyphenol derived from the spice turmeric, has been traditionally used for centuries in ancient indian medicine to treat a number of diseases. the physiological effects of cur have been shown to be diverse; however, the target molecules and pathways that cur affects have yet to be fully described.	2014	25523922
curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change.	a recent randomised, double-blind, placebo controlled study conducted by our research group, provided partial support for the efficacy of supplementation with a patented curcumin extract (500 mg, twice daily) for 8 weeks in reducing depressive symptoms in people with major depressive disorder. in the present paper, a secondary, exploratory analysis of salivary, urinary and blood biomarkers collected during this study was conducted to identify potential antidepressant mechanisms of action of curc ...	2015	25523883
turmeric improves post-prandial working memory in pre-diabetes independent of insulin.	cognitive impairment develops with pre-diabetes and dementia is a complication of diabetes. natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis.	2014	25516316
curcumin attenuates opioid tolerance and dependence by inhibiting ca2+/calmodulin-dependent protein kinase ii α activity.	chronic use of opioid analgesics has been hindered by the development of opioid addiction and tolerance. we have reported that curcumin, a natural flavonoid from the rhizome of curcuma longa, attenuated opioid tolerance, although the underlying mechanism remains unclear. in this study, we tested the hypothesis that curcumin may inhibit ca(2+)/calmodulin-dependent protein kinase ii α (camkiiα), a protein kinase that has been previously proposed to be critical for opioid tolerance and dependence. ...	2015	25515789
corrosion of orthodontic brackets in different spices: in vitro study.	moist environment in the mouth varies and causes variable amounts of corrosion of dental materials. this is of concern particularly when metallic implants, metallic fillings, orthodontic appliances are placed in the hostile electrolytic environment in the human mouth. components of diet rich in salt and spices are important factors influencing the corrosion of metallic appliances placed in the oral cavity.	2016	25511064
curcumin attenuated acute propionibacterium acnes-induced liver injury through inhibition of hmgb1 expression in mice.	curcumin is a phenolic product isolated from the rhizome of curcuma longa and has protective effects on inflammatory diseases. here we investigated the protective effect of curcumin in acute propionibacterium acnes (p. acnes)-induced inflammatory liver injury. c57bl/6 mice were primed with p. acnes followed by lps challenge to induce fulminant hepatitis. curcumin or vehicle control was administered perorally by gavage once daily starting 2days before p. acnes priming. we found that curcumin sign ...	2015	25510585
synergistic effect of curcumin in combination with anticancer agents in human retinoblastoma cancer cell lines.	curcumin (diferuloylmethane), a phenolic compound obtained from the rhizome of the herb curcuma longa, is known to have anti-proliferative and anti-tumor properties. in this study, we evaluated the cytotoxic effect of curcumin alone and in combination with individual drugs like carboplatin, etoposide, or vincristine in a human retinoblastoma (rb) cancer cell line.	2015	25495096
ras/erk signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma ags cells.	curcumin, the biologically active compound from the rhizome of curcuma longa, could inhibit cell growth and induce apoptosis in gastric carcinoma. however, the underlying mechanism of curcumin on gastric carcinoma cells still needs further investigation. in this study, morphological observation indicated that curcumin inhibited the proliferation of ags cells in a dose-dependent manner. according to the flow cytometric analysis, curcumin treatment resulted in g2/m arrest in ags cells, accompanied ...	2015	25492214
anti-inflammatory effects of novel standardized solid lipid curcumin formulations.	inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, alzheimer's disease, and cancer. an overwhelming amount of data indicates that curcumin, a polyphenol obtained from the indian spice turmeric, curcuma longa, is a potential chemopreventive agent for treating certain cancers and other chronic inflammatory diseases. however, the low bioavailability of curcumin, partly due to its low sol ...	2015	25490740
investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: a randomized double-blind placebo-controlled cross-over trial.	small dense low-density lipoprotein (sdldl) is a sub-fraction of ldl considered to have the most atherogenic properties. the present trial aimed to assess changes in circulating sdldl concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions.	2014	25477987
in vitro antidiabetic and inhibitory potential of turmeric (curcuma longa l) rhizome against cellular and ldl oxidation and angiotensin converting enzyme.	turmeric (curcuma longa l) rhizome extracts were evaluated for their antidiabetic, antihypertensive and antioxidant potentials. α-glucosidase (0.4 μg/ml) and α-amylase (0.4 μg/ml) inhibitory potential of turmeric ethyl acetate extract was significantly higher than those of the reference drug acarbose (17.1 μg/ml and 290.6 μg/ml respectively). protein glycation inhibitory potential of ethyl acetate extract was 800 times higher than that of ascorbic acid. high potential of ethyl acetate extract to ...	2014	25477660
evaluation of some selected herbs on arsenic-affected cattle in nadia district, west bengal, india.	arsenic poisoning due to contaminated subsoil water is one of the most alarming environment hazards in west bengal, india. cattle are also affected by arsenic due to ingestion of arsenic contaminated water, paddy straw, crops and vegetables. thirty milch cattle having arsenic content in the range of 3.5 to 4.5 mg/kg in hair were chosen for this experiment from cattle of five respective villages in nadia district, west bengal, india. the cattle were divided into three groups containing 10 animals ...	2015	25475613
curcumin and chronic kidney disease (ckd): major mode of action through stimulating endogenous intestinal alkaline phosphatase.	curcumin, an active ingredient in the traditional herbal remedy and dietary spice turmeric (curcuma longa), has significant anti-inflammatory properties. chronic kidney disease (ckd), an inflammatory disease, can lead to end stage renal disease resulting in dialysis and transplant. furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders. this review will focus on the clinically relevant inflammatory molecules that play a role in ckd ...	2014	25474287
the chemistry of curcumin: from extraction to therapeutic agent.	curcumin, a pigment from turmeric, is one of the very few promising natural products that has been extensively investigated by researchers from both the biological and chemical point of view. while there are several reviews on the biological and pharmacological effects of curcumin, chemistry reviews are comparatively scarcer. in this article, an overview of different aspects of the unique chemistry research on curcumin will be discussed. these include methods for the extraction from turmeric, la ...	2014	25470276
determination of toxic metals by icp-ms in asiatic and european medicinal plants and dietary supplements.	the potentially toxic metals content was determined in selected plants, used in traditional chinese medicine (angelica sinensis, bacopa monnieri, bupleurum sinensis, curcuma longa, cola accuminata, emblica officinalis, garcinia cambogia, mucuna pruriens, ocimum sanctum, panax ginseng, pueraria lobata, salvia miltiorrhiza, schisandra sinensis, scutellaria baicalensis, siraitia grosvenorii, terminalia arjuna and terminalia chebula), and some european herbs (echinacea purpurea, hypericum perforatum ...	2015	25467854
evaluation of saffron (crocus sativus l.) adulteration with plant adulterants by (1)h nmr metabolite fingerprinting.	in the present work, a preliminary study for the detection of adulterated saffron and the identification of the adulterant used by means of (1)h nmr and chemometrics is reported. authentic greek saffron and four typical plant-derived materials utilised as bulking agents in saffron, i.e., crocus sativus stamens, safflower, turmeric, and gardenia were investigated. a two-step approach, relied on the application of both opls-da and o2pls-da models to the (1)h nmr data, was adopted to perform authen ...	2015	25466103
spatial localisation of curcumin and rapid screening of the chemical compositions of turmeric rhizomes (curcuma longa linn.) using direct analysis in real time-mass spectrometry (dart-ms).	curcumin is a potent antioxidant agent having versatile biological activities is present in turmeric rhizomes (curcuma longa linn.). powder of turmeric rhizomes is consumes as curry spicy worldwide, especially in asia. in this study, we demonstrate that, bioactive curcumin and its analog demethoxycurcumin are chiefly concentrated in the pith rather than the other parts of the turmeric rhizomes and it was discovered using modern atmospheric ionisation source 'direct analysis in real time' (dart) ...	2015	25466050
protective effects of intranasal curcumin on paraquot induced acute lung injury (ali) in mice.	paraquot (pq) is widely and commonly used as herbicide and has been reported to be hazardous as it causes lung injury. however, molecular mechanism underlying lung toxicity caused by pq has not been elucidated. curcumin, a known anti-inflammatory molecule derived from rhizomes of curcuma longa has variety of pharmacological activities including free-radical scavenging properties but the protective effects of curcumin on pq-induced acute lung injury (ali) have not been studied. in this study, we ...	2014	25461551
curcumin ameliorates epithelial-to-mesenchymal transition of podocytes in vivo and in vitro via regulating caveolin-1.	epithelial-mesenchymal transition (emt) is recognized to play a key role in diabetic nephropathy (dn). curcumin, the main active component of turmeric extracted from the roots of the curcuma longa plant, has been reported for its anti-fibrotic effects in kidney fibrosis. the purpose of our study was to investigate the effects of curcumin in reversing epithelial-to-mesenchymal transition (emt) of podocytes in vivo and in vitro.	2014	25456852
curcumin inhibits oral squamous cell carcinoma scc-9 cells proliferation by regulating mir-9 expression.	curcumin, a phytochemical derived from the rhizome of curcuma longa, has shown anticancer effects against a variety of tumors. in the present study, we investigated the effects of curcumin on the mir-9 expression in oral squamous cell carcinoma (oscc) and explored the potential relationships between mir-9 and wnt/β-catenin pathway in curcumin-mediated oscc inhibition in vitro. as the results shown, the expression levels of mir-9 were significantly lower in clinical oscc specimens than those in t ...	2014	25450696
foliar application of β-d-glucan nanoparticles to control rhizome rot disease of turmeric.	the soilborne oomycete pythium aphanidermatum is the causal agent of rhizome rot disease, one of the most serious threats to turmeric crops. at present, effective fungicides are not available. researches on nanoparticles in a number of crops have evidenced the positive changes in gene expression indicating their potential use in crop improvement. hence, experiments were carried out to determine the effect of β-d-glucan nanoparticles (nanobiopolymer) in protection of turmeric plants against rot d ...	2015	25450542
anti-inflammatory and anti-periductal fibrosis effects of an anthocyanin complex in opisthorchis viverrini-infected hamsters.	the pharmacological activities of herbal extracts can be enhanced by complex formation. in this study, we manipulated cyanidin and delphinidin-rich extracts to form an anthocyanin complex (ac) with turmeric and evaluated activity against inflammation and periductal fibrosis in opisthorchis viverrini-infected hamsters. the ac was prepared from anthocyanins extracted from cobs of purple waxy corn (70%), petals of blue butterfly pea (20%) and turmeric extract (10%), resulting in an enhanced free-ra ...	2014	25447758
curcumin protects hearts from ffa-induced injury by activating nrf2 and inactivating nf-κb both in vitro and in vivo.	obesity and increased free fatty acid (ffa) level are tightly linked, leading to the development of cardiovascular disorders. curcumin is a natural product from curcuma longa with multiple bioactivities and is known to have cardioprotective effects in several cellular and animal models. the current study was designed to evaluate the cardioprotective effects of curcumin and demonstrate the underlying mechanism in ffa-induced cardiac injury. using cell culture studies and high fat in vivo model, w ...	2015	25444713
validation of an ultraviolet-visible (uv-vis) technique for the quantitative determination of curcumin in poly(l-lactic acid) nanoparticles.	curcumin is a natural yellow-orange pigment extracted from turmeric and is a potential substitute of health-dangerous artificial dyes. nanoencapsulation in biodegradable polymers is a promising alternative to improve curcumin stability and water solubility but curcumin concentration inside the nanoparticles must be precisely known. a reliable method to determine the actual curcumin concentration must be validated since the validation procedures warrant that the method is adequate and sufficient ...	2015	25442529
curcumin: a pleiotropic phytonutrient in diabetic complications.	curcumin is the major polyphenolic constituent of an indigenous herb, curcuma longa, found to have a wide range of applications right from its kitchen use as a spicy ingredient to therapeutic and medicinal applications in various diseases. curcumin has been identified to have a plethora of biologic and pharmacologic properties owing to its antioxidant and anti-inflammatory activities. this pleiotropic regulation of redox balance of cell and inflammation might be the basis of curcumin's beneficia ...	2015	25441584
histological studies of neuroprotective effects of curcuma longa linn. on neuronal loss induced by dexamethasone treatment in the rat hippocampus.	long term exposure to dexamethasone (dx) is associated with brain damage especially in the hippocampus via the oxidative stress pathway. previously, an ethanolic extract from curcuma longa linn. (cl) containing the curcumin constituent has been reported to produce antioxidant effects. however, its neuroprotective property on brain histology has remained unexplored. this study has examined the effects of a cl extract on the densities of cresyl violet positive neurons and glial fibrillary acidic p ...	2014	25440530
lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial.	dyslipidemia is an established feature of metabolic syndrome (ms) that is associated with an increased risk of atherosclerotic cardiovascular disease. curcuminoids are natural products with anti-atherosclerotic and lipid-modifying effects but their efficacy in patients with ms has not yet been tested.	2014	25440375
prostaglandin e2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (hct-15) cell lines.	prostaglandin e2 (pge2) promotes tumor-persistent inflammation, frequently resulting in cancer. curcumin is a diphenolic turmeric that inhibits carcinogenesis and induces apoptosis. pge2 inhibits curcumin-induced apoptosis; however, the underlying inhibitory mechanisms in colon cancer cells remain unknown. the aim of the present study is to investigate the survival role of pge2 and whether addition of exogenous pge2 affects curcumin-induced cell death. hct-15 cells were treated with curcumin and ...	2014	25431425
a diet enriched with curcumin impairs newly acquired and reactivated fear memories.	curcumin, a yellow-pigment compound found in the popular indian spice turmeric (curcuma longa), has been extensively investigated for its anti-inflammatory, chemopreventative, and antidepressant properties. here, we examined the efficacy of dietary curcumin at impairing the consolidation and reconsolidation of a pavlovian fear memory, a widely studied animal model of traumatic memory formation in posttraumatic stress disorder (ptsd). we show that a diet enriched with 1.5% curcumin prevents the t ...	2015	25430781
potential application of curcumin and its analogues in the treatment strategy of patients with primary epithelial ovarian cancer.	recent findings on the molecular basis of ovarian cancer development and progression create new opportunities to develop anticancer medications that would affect specific metabolic pathways and decrease side systemic toxicity of conventional treatment. among new possibilities for cancer chemoprevention, much attention is paid to curcumin-a broad-spectrum anticancer polyphenolic derivative extracted from the rhizome of curcuma longa l. according to clinicaltrials.gov at present there are no runni ...	2014	25429431
comparative evaluation of single application of 2% whole turmeric gel versus 1% chlorhexidine gel in chronic periodontitis patients: a pilot study.	to evaluate and compare the clinical effects of topical subgingival application of 2% whole turmeric gel and 1% chlorhexidine gel as an adjunct to scaling and root planing (srp) in patients suffering from chronic periodontitis.	2014	25425818
oral administration of curcumin (curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats.	to evaluate the effect of curcumin in the acute phase of zymosan-induced arthritis.	2014	25424293
curcuma oil attenuates accelerated atherosclerosis and macrophage foam-cell formation by modulating genes involved in plaque stability, lipid homeostasis and inflammation.	in the present study, the anti-atherosclerotic effect and the underlying mechanism of curcuma oil (c. oil), a lipophilic fraction from turmeric (curcuma longa l.), was evaluated in a hamster model of accelerated atherosclerosis and in thp-1 macrophages. male golden syrian hamsters were subjected to partial carotid ligation (pcl) or fecl3-induced arterial oxidative injury (ox-injury) after 1 week of treatment with a high-cholesterol (hc) diet or hc diet plus c. oil (100 and 300 mg/kg, orally). ha ...	2015	25391643
curcumin reverse methicillin resistance in staphylococcus aureus.	curcumin, a natural polyphenolic flavonoid extracted from the rhizome of curcuma longa l., was shown to possess superior potency to resensitize methicillin-resistant staphylococcus aureus (mrsa) to antibiotics. previous studies have shown the synergistic activity of curcumin with β-lactam and quinolone antibiotics. further, to understand the anti-mrsa mechanism of curcumin, we investigated the potentiated effect of curcumin by its interaction in diverse conditions. the mechanism of anti-mrsa act ...	2014	25389660
coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats.	among noncommunicable diseases, metabolic syndrome (ms), a cluster of metabolic disorders including obesity, hyperglycemia, hyperlipidemia and hypertension, is highly prevalent in modern society. its management requires lifestyle modifications and/or the life-long use of multiple medications, hence demanding development of safe alternative remedies. this study was aimed to establish the efficacy of combined use of black seeds and turmeric using fructose-fed rat model of ms. the high-performance ...	2015	25384193
rhynchophorus ferrugineus midgut cell line to evaluate insecticidal potency of different plant essential oils.	cell cultures can be a potent and strong tool to evaluate the insecticidal efficiency of natural products. plant essential oils have long been used as the fragrance or curative products around the world which means that they are safer to be used in close proximity of humans and mammals. in this study, a midgut cell line, developed from rhynchophorus ferrugineus (rpw-1), was used for screening essential oils from nine different plants. assays revealed that higher cell mortality was observed at 50 ...	2015	25381034
a critical examination of studies on curcumin for depression.	curcumin, an ingredient of turmeric, is widely available as a nutritional supplement. curcumin has biological properties that suggest its use for a large number of health-related conditions, including depression. curcumin is effective in animal models of depression. however, controlled clinical trials provide no convincing evidence that patients with major depressive illness fare better with different extracts of curcumin (dosed at 500-1,000 mg/d) than with placebo (or no treatment) after 5-8 we ...	2014	25373119
total anti-oxidant capacity, flavonoid, phenolic acid and polyphenol content in ten selected species of zingiberaceae rhizomes.	natural products such as herbs, fruits, spices, beverages, vegetables are becoming more popular among scientific community and consumers because of their potential to arrest the effect of free radicals in human system. this study determined the total antioxidant capacity of ten selected species of zingiberaceae (ginger) used as spices and for medicinal purposes in southeast asia.	2014	25371557
pharmacological intervention through dietary nutraceuticals in gastrointestinal neoplasia.	neoplastic conditions associated with gastrointestinal (gi) tract are common worldwide with colorectal cancer alone accounting for the third leading rate of cancer incidence. other gi malignancies such as esophageal carcinoma have shown an increasing trend in the last few years. the poor survival statistics of these fatal cancer diseases highlight the need for multiple alternative treatment options along with effective prophylactic strategies. worldwide geographical variation in cancer incidence ...	2016	25365584
low-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing cells.	one of the promising strategies for neural repair therapies is the transplantation of olfactory ensheathing cells (oecs) which are the glial cells of the olfactory system. we evaluated the effects of curcumin on the behaviour of mouse oecs to determine if it could be of use to further enhance the therapeutic potential of oecs. curcumin, a natural polyphenol compound found in the spice turmeric, is known for its anti-cancer properties at doses over 10 µm, and often at 50 µm, and it exerts its eff ...	2014	25360677