Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| effect of ca2+ on the action of cobra (naja naja oxiana eichwald) venom components on mitochondrial enzyme systems. | 1984 | 6526419 | |
| amino acid sequence of cytotoxin iia isolated from the venom of the indian cobra (naja naja). | a cytotoxic basic polypeptide, designated as cytotoxin iia, was purified to homogeneous state from the venom of the indian cobra (naja naja) by a combination of gel filtration on sephadex g-50, cm-cellulose chromatography, and fast protein liquid chromatography. cytotoxin iia is a single polypeptide consisting of 60 amino acid residues with four intramolecular disulfide linkages. the toxin showed high cytotoxicity toward yoshida sarcoma and ascites hepatoma cells as did cytotoxins i and ii isola ... | 1984 | 6525197 |
| effect of carboxylate group modification on enzymatic and cardiotoxic properties of snake venom phospholipases a2. | by treating naja nigricollis and naja naja atra phospholipase a2 with carbodiimide and semicarbazide, we obtained derivatives having varied numbers of modified carboxylate groups. when tested on artificial and natural substrates, derivatives of both enzymes with a modified carboxylate group at the active site (asp-49) retained little enzymatic activity (1/41 to 10%). however, the derivatives of n. nigricollis also lost most of their lethal potency (5% of native), while those of n. n. atra retain ... | 1984 | 6523504 |
| [complement and noncomplement hemolysis of blood cells in patients with various blood diseases after the administration of the crude toxins of agkistrodon piscivorus, naja naja, naja oxiana]. | 1984 | 6515308 | |
| evidence for a highly asymmetric arrangement of ether- and diacyl-phospholipid subclasses in the plasma membrane of krebs ii ascites cells. | (1) krebs ii ascites cells were taken as a model of the neoplastic cells to investigate the transverse distribution of phospholipids in the plasma membrane. the experimental procedure was based on non-lytic degradation of phospholipids in the intact cell by naja naja phospholipase a2 and staphylococcus aureus sphingomyelinase c and on phospholipid analysis of purified plasma membranes. it was shown that the three major phospholipids, i.e., phosphatidylcholine, phosphatidylethanolamine and sphing ... | 1984 | 6509047 |
| clinical features of neurotoxic snake bite and response to antivenom in 47 children. | among 47 children admitted to the chulalongkorn medical school hospital for neurotoxic snake bite, the attackers were identified in 15; the cobra (naja naja) was the snake involved in all cases. clinical manifestations in all 47 children appeared to follow a similar pattern. drowsiness heralded the systemic effects in most of the patients. the characteristic systemic signs were those resulting from the neuromuscular effects of the venom and included ptosis, frothy saliva, slurred speech, respira ... | 1984 | 6507733 |
| reoxidation and renaturation studies on the main toxin of naja naja samarensis. | the main toxin of naja naja samarensis is a very small and rigid protein (mr 6850, 8 cysteines). when fully reduced, it regains its native conformation by a mechanism involving a rapid cysteine oxidation and a slower, less temperature-dependent disulfide exchange. in a native-like form of the protein we observed a population whose cysteines were incompletely reoxidized. when intermediates with blocked cysteines were incubated with oxidized and reduced glutathione, the percentage of native-like m ... | 1984 | 6500055 |
| photochemically induced nuclear polarization study of exposed tyrosines, tryptophans, and histidines in postsynaptic neurotoxins and in membranotoxins of elapid and hydrophid snake venoms. | the accessibility of surface tyrosines, histidines, and tryptophans in snake venom neurotoxins (short and long) and in membranotoxins to excited triplet 10-(carboxyethyl)-flavin was studied by photochemically induced dynamic nuclear polarization at 270 mhz. trp-29 is accessible in the short neurotoxins--erabutoxins a, b, and c and cobrotoxin--and also in the long neurotoxins--alpha-cobratoxin and alpha-bungarotoxin. tyr-25 is practically inaccessible in all neurotoxins. tyr-39 in cobrotoxin and ... | 1984 | 6498168 |
| cobra venom factor: improved method for purification and biochemical characterization. | a method to purify cobra venom factor (cvf) from cobra venom by sequential column chromatography is described which yields a product virtually free of phospholipase a2, a common contaminant of cvf preparations. the separation of phospholipase a2 from cvf was achieved by chromatography on cibacron blue-agarose, a resin that tightly binds cobra venom phospholipase a2. a rapid and simple hemolytic assay for the qualitative and quantitative determination of cvf based on its ability to induce bystand ... | 1984 | 6491300 |
| effect of central asian cobra (naja naja oxiana eichwald) venom cytotoxin on enzymatic hydrolysis of phospholipids. | 1984 | 6490078 | |
| joint action of membrane-active components from central asian cobra (naja naja oxiana eichwald) venom on rat liver mitochondrial functions. | 1984 | 6490077 | |
| [relative localization of the bound acetylcholine receptor subunits and neurotoxin]. | a series of neurotoxin ii (naja naja oxiana) derivatives, each containing one p-azido-[14c]benzoyl group, have been prepared. those labeled at leu1, lys15, lys25, lys26, or lys46 associate specifically with the acetylcholine receptor from the torpedo marmorata electric organs and form the crosslinks with it as a result of irradiation. electrophoresis in polyacrylamide gel and gel chromatography revealed the contacts between the neurotoxins and alpha, beta, gamma and delta subunits of the recepto ... | 1984 | 6487390 |
| inactivation of toxin b from the indian cobra by cleavage of a specific bond during limited hydrolysis with trypsin. | two neurotoxins, "toxin b", a long neurotoxin from naja naja, and "cobrotoxin", a short neurotoxin from naja naja atra, were compared with respect to their limited hydrolysis by trypsin and chymotrypsin and its effect on their neurotoxicity. limited hydrolysis of toxin b with trypsin cleaves peptide bonds at arg68-lys69 and arg33-gly34 in the toxin molecule and causes complete loss of the neurotoxicity yielding des-carboxyl terminal toxin b(1-68) nicked at arg33-gly34 in the molecule. on the oth ... | 1984 | 6487344 |
| catabolism of phospholipids by chicken seminal components after storage. | the possibility of an activation of chicken spermatozoal phospholipase a2 during in vitro storage of undiluted semen was investigated. after storage for periods up to 24 hr at 5 c, the ability of semen to catabolize added phosphatidylcholine labeled on the 2nd carbon of glycerol with 14c oleic acid was assessed. neither spermatozoa nor plasma from undiluted chicken semen was found to be capable of catabolizing added 14c labeled phosphatidylcholine, regardless of the storage period. no enzyme act ... | 1984 | 6483728 |
| cardiotoxin from naja naja atra snake venom: a potentiator of platelet aggregation. | cardiotoxin, isolated from naja naja atra snake venom, potentiates platelet aggregation induced by adp, thrombin, collagen and venom phospholipase a2. the malondialdehyde formation caused by adp, thrombin and venom phospholipase a2 were also increased in the presence of cardiotoxin. both potentiation of aggregation and increase in malondialdehyde were blocked by indomethacin or ca2+ (5 mm or 0.05 mm). cardiotoxin did not potentiate thrombin-induced aggregation of p-bromophenacyl bromide-modified ... | 1984 | 6474495 |
| variation in yield and lethality of venoms from iranian snakes. | the dangerous venomous terrestrial snakes of iran belong to three groups: the elapidae (cobras); the viperinae (true vipers); the crotalinae (pit vipers). geographical distribution of each species was determined. studies on the venoms extracted from the following iranian snakes, oxus cobra, naja naja oxiana, levantine viper (afyi), vipera lebetina, carpet viper, echis carinatus, persian horned viper, pseudocerastes persicus, latifii viper, vipera latifii, mountain viper, vipera xanthina and cauc ... | 1984 | 6474490 |
| effect of the purified phospholipases a2 from snake and bee venoms on rabbit platelet function. | effects of seven purified phospholipases a2 from the venoms of snakes (naja naja atra, trimeresurus mucrosquamatus and t. gramineus) and honey bee (apis mellifera) on rabbit washed platelet suspension in the absence of bovine serum albumin have been studied. only phospholipases a2 from n. n. atra, t. mucrosquamatus and a. mellifera venoms induced platelet aggregation with small amounts of 14c-serotonin release. they showed tachyphylaxis and also cross-tachyphylaxis in inducing platelet aggregati ... | 1984 | 6441310 |
| [nmr study of the spatial structure of the naja naja siamensis toxin 3]. | the 300 and 500 mhz 1h nmr spectra of a long-chain neurotoxin, toxin 3 naja naja siamensis (s-t3), its derivatives and close homolog, toxin 3 naja naja naja (n-t3), have been analyzed. a combination of double resonance, difference spectroscopy and usage of a series of toxin s-t3 derivatives acetylated or trifluoroacetylated at lysine residues allowed to assign the signals from all aromatic protons and a number of signals in the aliphatic region, and to elucidate the microenvironment of certain f ... | 1984 | 6437411 |
| effects of chicken and mammalian gonadotropin-releasing hormones (gnrh) on in vivo pituitary gonadotropin release in amphibians and reptiles. | the ability of mammalian and chicken gonadotropin-releasing hormones (gnrh) and their agonistic analogs to stimulate in vivo gonadotropin release were tested in a frog (rana catesbeiana), snake (naja naja), and turtle (sternotherus odoratus). in the frog, chicken and mammalian gnrh were equipotent in stimulating the release of fsh and lh. attendant increases in plasma androgen and the occurrence of spermiation confirmed the release of biologically active gonadotropin. neither of the gnrh prepara ... | 1984 | 6427062 |
| changes in membrane phospholipid distribution during platelet activation. | exposure of phospholipids at the outer surface of activated and control platelets was studied by incubation with a mixture of phospholipase a2 from naja naja and bee venom, solely or in combination with sphingomyelinase from staphylococcus aureus, using conditions under which cell lysis remained below 10%. incubation with phospholipase a2 alone revealed a markedly increased susceptibility of the phospholipids in platelets activated by a mixture of collagen plus thrombin, by the sh-oxidizing comp ... | 1983 | 6418205 |
| proteolytic-independent cobra neurotoxin inhibiting activity of curcuma sp. (zingiberaceae). | the 1: 1 (w/v) aqueous extract of curcuma sp. (zingiberaceae) was shown to antagonize the toxic action of naja naja siamensis neurotoxin possibly via direct inactivation of the toxin. the plant extract possessed proteolytic activity which could be separated from the neurotoxin inhibiting activity. the mechanism of antagonism between the plant extract and the neurotoxin was shown not to be involved with the existence of proteolytic activity in the plant extract. | 1983 | 6356379 |
| on the interaction of cobra venom protein cardiotoxins with erythrocytes. | the principally active hemolytic toxin (cardiotoxin) previously purified from the venom of the thailand cobra, naja naja siamensis, was shown to produce spontaneous twitching, contractures and membrane depolarization in sartorius muscles from the frog, rana pipiens. spontaneous twitching, observed at concentrations greater than 0.1 um was completely abolished by addition of tetrodotoxin and not affected by d-tubocurarine. dose and time dependent membrane depolarization of muscle fibers was obser ... | 1984 | 6333874 |
| [specificity of the nuclease from the venom of the middle asia cobra (naja naja oxiana) to the macrostructure of polyribonucleotides]. | 2017 | 6312288 | |
| induction of ornithine decarboxylase by treatment of guinea pig lymphocytes with phospholipase c. | treatment of guinea pig lymphocytes with clostridium perfringens phospholipase c but not with naja naja snake venom phospholipase a2 increased ornithine decarboxylase activity. the increase in ornithine decarboxylase activity was suppressed by actinomycin d or cycloheximide, suggesting that de novo syntheses of rna and protein are necessary for the increase in the enzyme activity. these results suggest that the activation of phospholipase c rather than that of phospholipase a2 is responsible for ... | 1983 | 6299785 |
| fractionation of protein components of plasma membranes from the electric organ of torpedo marmorata. | a procedure has been developed for the separation of intrinsic proteins of plasma membranes from the electric organ of torpedo marmorata. (na+ + k+)-atpase, nicotinic acetylcholine receptor and acetylcholinesterase remained active after solubilization with the nonionic detergent dodecyl octaethylene glycol monoether (c12e8). these components could be separated by ion exchange chromatography on deae-sephadex a-25. fractions enriched in ouabain-sensitive k+-phosphatase or (na+ + k+)-atpase activit ... | 1982 | 6297554 |
| individual assignments of the amide proton resonances involved in the triple-stranded antiparallel pleated beta-sheet structure of a long neurotoxin, laticauda semifasciata iii from laticauda semifasciata. | the characteristic feature of the crystal structure of erabutoxin b, a short neurotoxin from laticauda semifasciata, and alpha-cobratoxin, a long neurotoxin from naja naja siamensis, is the presence of a triple-stranded antiparallel pleated beta-sheet structure formed by the central and the third peptide loops. in the present study, we have studied the assignment of slowly exchangeable amide protons of laticauda semifasciata iii from l. semifasciata, using nuclear overhauser effects (noe) and sp ... | 1982 | 6279398 |
| inactivation and solubilization of opiate receptors by phospholipases a2. | (1) as previously shown, stereospecific binding of opiates to membrane bound receptors is inhibited by treatment with small amounts of phospholipase a2 from vipera russelli. this effect is quantified and compared with the enzymes from the venoms of naja naja siamensis, apis mellifica and from porcine pancreas. all enzymes are equally effective. the inhibition is due to partial phospholipid hydrolysis leading to inactivation of membrane-bound receptor. (2) bee venom phospholipase a2 together with ... | 1982 | 6279149 |
| location of single-stranded and double-stranded regions in rat liver ribosomal 5s rna and 5.8s rna. | rat liver 5s rrna and 5.8s rrna were end-labelled with 32p at 5'-end or 3'-end of the polynucleotide chain and partially digested with single-strand specific s1 nuclease and double-strand specific endonuclease from the cobra naja naja oxiana venom. the parallel use of these two structure-specific enzymes in combination with rapid sequencing technique allowed the exact localization of single-stranded and double-stranded regions in 5s rna and 5.8 s rna. the most accessible regions to s1 nuclease i ... | 1981 | 6272219 |
| biochemical characterization of a toxin from indian cobra (naja naja naja) venom. | 1981 | 6267739 | |
| the effects of alpha- and beta-neurotoxins from the venoms of various snakes on transmission in autonomic ganglia. | we have previously shown that certain commercially available lots of alpha-bungarotoxin block transmission in ciliary and choroid neurons of both pigeon and chicken ciliary ganglia at a concentration of 10 microgram/ml (1.2 microm). the blockade is antagonized by pre-incubation with 100 microm tubocurarine. further evidence that this blockade is produced by a postsynaptic action, as one would expect of an alpha-neurotoxin, are our findings that: (a) exposure to the toxin prevents the depolarizat ... | 1981 | 6261879 |
| the deacetylation of n-hydroxy-2-acetylaminofluorene by rat liver microsomes and carboxyl esterase. | we have demonstrated that incubation of rat liver microsomes with n-hydroxy-2-acetylaminofluorene (n-oh-aaf) leads to formation of a 2-nitrosofluorene-membrane lipid adduct. this adduct exists as a nitroxyl free radical, termed n-o-laf, in its oxidized state. when microsomes were incubated with the sulfhydryl binding agent, rho-hydroxymercuribenzoate, a larger amount of n-ol-laf formed. we interpret this as a slowdown in the rate of endogenous chemical reduction of carcinogen-membrane lipid addu ... | 1980 | 6260332 |
| [fluorescence characteristics of lysine and arginine residues in venom of naja naja atra]. | 1984 | 6239506 | |
| properties of curaremimetic neurotoxin binding sites in the rat central nervous system. | properties of mammalian central nervous system binding sites for curaremimetic neurotoxins are investigated with the simonsen-albino rat and 125i-labeled alpha-bungarotoxin or the principal neurotoxin from naja naja siamensis. evidence is presented that high-affinity toxin binding sites are distributed as expected for a synaptic neurotransmitter receptor, display distinct nicotinic cholinergic pharmacology, and are sensitive to preincubation with nicotinic agonists. affinity of toxin sites for a ... | 1984 | 6231955 |
| anaerobic metabolism of carbon tetrachloride and formation of catabolically resistant phospholipids. | anaerobic incubation of microsomes with 14c-carbon tetrachloride leads to trichloromethyl radicals which, apart from other detrimental reactions, bind covalently to phospholipids. these labelled lipids are extracted, phosphatidylcholine is isolated and incubated with phospholipase a2 from naja naja snake venom and from porcine pancreas. half of the covalently modified phosphatidylcholine is resistant toward phospholipase a2. distribution of such catabolically resistant phospholipids from the end ... | 1984 | 6231931 |
| studies on snake venom enzymes: part i. purification of atpase, a toxic component of naja naja venom & its inhibition by potassium gymnemate. | 1982 | 6215333 | |
| higher-order structure in the 3'-terminal domain vi of the 23 s ribosomal rnas from escherichia coli and bacillus stearothermophilus. | an experimental approach was used to determine, and compare, the higher-order structure within domain vi of the 23 s ribosomal rnas from escherichia coli and bacillus stearothermophilus. this domain, which encompasses approximately 300 nucleotides at the 3' end of the rnas, consists of two large subdomains. the 5' subdomain has been conserved during evolution and appears to be functionally important for the binding of the ef-1 x gtp x aminoacyl-trna complex in eukaryotes. the 3' subdomain has di ... | 1984 | 6209406 |
| proteolytic activities of cobra venoms based on inactivation of alpha 2-macroglobulin. | the venoms of various cobra species showed a wide range of abilities to cleave hide powder azure, with naja naja kaouthia and ophiophagus hannah venoms showing the lowest activities and naja nivea venom showing the greatest activity on this dye-linked substrate. the activities of the venoms on hide powder did not completely correlate with their ability to inactivate the alpha 2-macroglobulin of human serum. incubation of 4-5 micrograms of naja nigricollis venom per microliter of serum for 30 min ... | 1984 | 6197999 |
| higher order structure in the 3'-minor domain of small subunit ribosomal rnas from a gram negative bacterium, a gram positive bacterium and a eukaryote. | an experimental approach was used to determine and compare the highest order structure within the 150 to 200 nucleotides at the 3'-ends of the rnas from the small ribosomal subunits of escherichia coli, bacillus stearothermophilus and saccharomyces cerevisiae. chemical reagents were employed to establish the degree of stacking and/or accessibility of each adenosine, guanosine and cytidine. the double helices were probed with a cobra venom ribonuclease from naja naja oxiana, and the relatively un ... | 1983 | 6194304 |
| antigenic relationships between human and cobra complement factors c3 and cobra venom factor (cvf) from the indian cobra (naja naja). | the presence of a factor immunologically related to cobra venom factor (cvf) was demonstrated in serum and plasma from the indian cobra (naja naja kaoutia). the factor was purified from cobra plasma by affinity chromatography on an anti-cvf gel and was found to consist of a protein composed of two polypeptide chains similar in size to those of human c3. with use of immunoblotting technique, common antigenic determinants were found in the smaller chain of the prepared material and the beta-chain ... | 1983 | 6194220 |
| purification and characterization of anticomplement factor (cobra venom factor) from the naja naja atra venom. | anticomplement factor (cobra venom factor) from the venom of naja naja atra was purified by means of successive chromatography on deae-cellulose, sephadex g-200 and sepharose cl-6b. the purified anticomplement factor was homogeneous as judged by polyacrylamide discontinuous gel electrophoresis at ph 9.4. the yield from 3.0 g of the crude venom was approx. 28 mg. the molecular weight was estimated to be about 156 000 by sds-polyacrylamide gel electrophoresis. the isoelectric point was about 5.2. ... | 1982 | 6173071 |
| cytoarchitectonic pattern of the hypothalamus in the cobra, naja naja. | the distribution and cytoarchitectonic pattern of the magno- and parvocellular hypothalamic nuclei of the cobra. naja naja, are described at the light-microscopic level. with respect to their tinctorial affinity to paraldehyde fuchsin (af) as a representative of the gomori-type of stains, the magnocellular neurons belong to the "af-positive" and the parvocellular neurons to the "af-negative" elements. in addition to the supraoptic and paraventricular nuclei proper, two accessory aggregations of ... | 1981 | 6166381 |
| inhibition of biological activity of mouse beta-nerve growth factor by monoclonal antibody. | a continuous hybrid cell line was derived that secretes monoclonal antibody capable of inhibiting the biological activity of mouse beta-nerve growth factor (beta-ngf). results obtained with monovalent fragments indicate that the monoclonal antibody inhibits activity by interfering with the direct interaction between beta-ngf and the cell membrane receptor rather than by precipitating the dimeric form of beta-ngf. this monoclonal antibody binds to an antigenic determinant common to mouse beta-ngf ... | 1980 | 6159686 |
| a comparison of eel electroplax and snake venom acetylcholinesterase. | the effects of some cholinergic ligands, harmala alkaloids and local anesthetics on the activity of eel electroplax and naja naja siamensis venom acetylcholinesterase have been studied. in most cases, eel electroplax was found to be more susceptible towards inhibition than the venom acetylcholinesterase. no major difference was observed with respect to the type of inhibition in both enzymes. the activation of the two enzyme preparations by inorganic cations (ca2+, mg2+ and na+) showed a similar ... | 1984 | 6146473 |
| effects of beta-bungarotoxin and phospholipase a2 from naja naja atra snake venom on atpase activities of synaptic membranes from rat cerebral cortex. | non-neurotoxic phospholipase a2 of formosan cobra venom possessed higher hydrolytic activity on phosphatidylcholine vesicles and also had higher inhibitory action on na+-k+-atpase and mg2+-atpase of the rat synaptic membrane than neurotoxic beta-bungarotoxin of formosan krait venom. na+-k+-atpase was more susceptible than mg2+-atpase to the inhibitory action of toxins, especially in the presence of triton x-100. the inhibition of atpases by toxins followed the michaelis-menton equation. it is in ... | 1982 | 6123164 |
| snake alpha-toxin effects on cholinergic and noncholinergic responses of aplysia californica neurons. | the effects of alpha-toxins from bungarus multicinctus (alpha butx) and naja naja siamensis (alpha ntx) were studied on synaptic responses and on extrasynaptic responses to focally applied acetylcholine (ach), histamine (hm), gamma-aminobutyric acid (gaba), and glutamate (glu) in neurons of the marine mollusc, aplysia californica. binding of 125i-alpha butx to aplysia ganglia homogenates was pharmacologically characterized and compared with the pharmacological sensitivity of 125i-alpha butx bind ... | 1981 | 6114995 |
| [preparation and esr study of spin-labeled derivatives of naja naja oxiana neurotoxin ii]. | after neurotoxin ii naja naja oxiana reaction with n-hydroxysuccinimidyl 2,2,6,6-tetramethyl-4-carboxymethylpiperidine-1-oxyl, six derivatives were isolated, each containing one spin label. their analysis (reduction, carboxymethylation, tryptic hydrolysis, isolation and identification of the spin labeled peptide) allowed to localize the label position: the epsilon-amino groups of lys15, lys25, lys26, lys44, lys48, and alpha-amino group of leu1. the neurotoxin ii reaction with n-hydroxysuccinimid ... | 1983 | 6091692 |
| the effects of whole cobra venom (naja naja) and its fractions on the heart. | 1967 | 6080378 | |
| the neurohypophysial hormones of a reptile species, the cobra (naja naja). | 1967 | 6057829 | |
| seasonal changes in the testis of the cobra, naja naja (linn). | 1966 | 6007029 | |
| pharmacological properties of cardiotoxin isolated from the venom of naja naja atra. | 1966 | 6002954 | |
| [venom of the cobra (naja naja) and neuromuscular paralyzing agents]. | 1966 | 5952128 | |
| lipid monolayers: action of phospholipase a of crotalus atrox and naja naja venoms on phosphatidyl choline and phosphatidal choline. | the activity of phospholipase a on phosphatidyl choline and phosphatidal choline spread as monolayers on phosphate buffers containing snake venom (crotalus atrox or naja naja) was studied by measuring the fall of surface potential as a function of time, ph, film pressure, temperature, and concentrations of phosphate and venom. at 25 degrees c, ph 7.0, and 0.2 micrograms of venom per ml, optimal activity was observed with both venoms on both substrates at 12 dynes/cm film pressure on 0.04 m phosp ... | 1966 | 5947040 |
| sphaerechinorhynchus serpenticola sp. n. (acanthocephala: sphaerechinorhynchinae), a parasite of the asian cobra, naja naja (cantor), in borneo (malaysia). | 1966 | 5927219 | |
| isolation of three different neurotoxins from indian cobra (naja naja) venom and the relation of their action to phospholipase a. | 1965 | 5880536 | |
| study of hemolysis in the lethal effect of naja naja venom in the mouse and guinea pig. | 1969 | 5823352 | |
| seasonal changes in the in vitro production of testicular androgens by the cobra (naja naja linn). | 1969 | 5817028 | |
| seasonal changes in the thyroid gland in the male cobra, naja naja l. | 1969 | 5798451 | |
| seasonal variations in histology and corticosteroid synthesis in vitro in the adrenal of the cobra (naja naja). | 1969 | 5775360 | |
| central neurotoxic effects of the venoms of naja naja and vipera palestinae. | 1968 | 5710997 | |
| isolation of phospholipase a isoenzymes from naja naja venom and their action on membrane-bound enzymes. | 1968 | 5705754 | |
| isolation of the principal neurotoxins of two naja naja subspecies. | 1971 | 5568672 | |
| the n-terminal amino acid sequences of two basic cytotoxic proteins from the venom of the indian cobra. | 1971 | 5564473 | |
| seasonal changes in the histology of the adrenal gland of the cobra, naja naja. | 1971 | 5542988 | |
| phospholipase a of snake venoms. ii. catalytic properties of the enzyme from naja naja. | 1971 | 5542004 | |
| phospholipase a of snake venoms. i. isolation and molecular properties of isoenzymes from naja naja and vipera russellii venoms. | 1971 | 5542003 | |
| the amino acid sequence of cardiotoxin from formosan cobra (naja naja atra) venom. | 1970 | 5518165 | |
| anesthetic deaths in cobras (naja naja and ophiophagus hannah) with methoxyflurane. | 1970 | 5465566 | |
| purification and some properties of toxin a from the venom of the indian cobra. | 1970 | 5447860 | |
| long-lasting convulsant effect on the cerebral cortex of naja naja venom. | 1. a neurotoxic fraction has been prepared from indian cobra venom (naja naja) by column chromatography on cm sephadex.2. when assayed for lethality in mice, or for neuromuscular blocking potency in the rat phrenic nerve-diaphragm preparation, this fraction was 2.4-2.9 times as potent as whole venom.3. application of either whole venom (0.5-1.0 mg/ml) or the neurotoxic fraction (0.25-1.0 mg/ml) to the exposed cerebral cortex of the rat led to the appearance in the somatosensory evoked potential ... | 1970 | 5425281 |
| chemical composition of naja naja: extractable lipids. | 1969 | 5358066 | |
| comparison of hemorrhagic factors of the venoms of naja naja, agkistrodon piscivorus and apis mellifera. | 1970 | 5315472 | |
| purification and some properties of toxin a from the venom of the indian cobra (naja naja). | 1971 | 5314268 | |
| chemical modification of cobratoxin from the venom of formosan cobra (naja naja atra). | 1970 | 5313270 | |
| nerve growth factor from cobra venom. | the chemical and biological properties of the nerve growth factor isolated from naja naja venom are described. the nerve growth promoting activity appears to be distinct from the most commonly known enzymes and toxins present in the venom. the purified nerve growth factor from cobra venom has properties remarkably similar to those of the nerve growth factor isolated from mouse submaxillary gland. these findings are discussed in connection with the problem of the physiological function of this un ... | 1970 | 5267146 |
| amino acid sequence of toxin a from the venom of the indian cobra (naja naja). | 1971 | 5125232 | |
| isolation of the principal neurotoxins of naja naja subspecies from the asian mainland. | 1972 | 5072086 | |
| some effects of guinea pig serum and heparin on hemolysis induced by naja naja, agkistrodon piscivorus and apis mellifera venom. | 1972 | 5070580 | |
| role of cardiotoxin and phospholipase a in the blockade of nerve conduction and depolarization of skeletal muscle induced by cobra venom. | 1. the effects of phospholipase a (pha), cardiotoxin (ctx) and neurotoxin (cobrotoxin) isolated from formosan cobra (naja naja atra) venom on conduction of the rat phrenic nerve and membrane potential of the rat diaphragm were studied.2. phospholipase a, lysolecithin and cobrotoxin were without effect on the axonal conduction. cardiotoxin was the only active agent in cobra venom, but it was less potent than the crude venom.3. the blocking action of cardiotoxin was markedly accelerated by the sim ... | 1972 | 5041453 |
| neurotoxin from venom of the cobra, naja naja siamensis. purification and radioactive labeling. | 1972 | 5027738 | |
| [a study of the fractions obtained by chromatography of the venom of naja naja atra on sulphoethyl-sephadex]. | 1968 | 4971838 | |
| comparison of naja naja siamensis and naja naja atra venoms. | 1968 | 4966517 | |
| amino acid sequence of oxiana alpha, the main neurotoxin of the venom of naja naja oxiana. | 1974 | 4850498 | |
| modification of the invariant tryptophan residue of two naja naja neurotoxins. | 1973 | 4776457 | |
| localization of the five disulfide bridges in toxin b from the venom of the indian cobra (naja naja). | 1973 | 4767311 | |
| phospholipase isoenzymes from naja naja venom. ii. phospholipase a and b activities. | 1973 | 4762267 | |
| amino acid sequence of neurotoxin ii from naja naja oxiana venom. | 1973 | 4747603 | |
| irradiated cobra (naja naja philippinensis) venom. | 1973 | 4734465 | |
| kinetic dependence of phospholipase a 2 activity on the detergent triton x-100. | a kinetic analysis is presented for the dependence of one form of phospholipase a(2) from cobra (naja naja) venom on the presence of the nonionic detergent triton x-100 for its activity towards egg phosphatidylcholine and synthetic dipalmitoyl glycerophosphorylcholine as substrates. an automatic recording ph-stat apparatus was employed in order to continuously monitor enzyme activity. the results obtained in this study are interpreted in terms of a change in the physical state of the phospholipi ... | 1973 | 4698263 |
| haemolysis of washed human red cells by the combined action of naja naja phospholipase a 2 and albumin. | 1972 | 4674345 | |
| localization of the four disulfide bridges in cytotoxin ii from the venom of the indian cobra (naja naja). | 1972 | 4674343 | |
| isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized naja naja neurotoxin. | 1972 | 4646866 | |
| seasonal changes in the secretory activity of adrenal gland of the cobra (naja naja, linn.). | 1972 | 4635455 | |
| amino acid sequences of toxin a and two basic proteins from the venom of the indian cobra (naja naja). | 1972 | 4539448 | |
| local necrosis induced by cobra (naja naja atra) venom. | 1972 | 4539445 | |
| irradiated cobra (naja naja philippinensis) venom. | 1972 | 4539443 | |
| the affinity-labeling of partially purified acetylcholine receptor from electric tissue of electrophorus. | the receptor for acetylcholine was partially purified by affinity chromatography of an extract in triton x-100 of membrane fragments from electric tissue. the receptor was assayed, after its reduction with dithiothreitol, by reaction with the affinity-alkylating agent, [methyl-(3)h]4-(n-maleimido)-benzyltrimethylammonium iodide. alternative labeling procedures, one useful for routine assay of picomole quantities of receptor and the other for labeling larger quantities of receptor, are described. ... | 1973 | 4519650 |
| the role of direct lytic factor (dlf) and phospholipase-a in the local hemorrhagic effect of naja naja venom. | 1972 | 4512909 | |
| chemical studies on phospholipase a from formosan cobra (naja naja atra) venom. | 1972 | 4512906 | |
| appearance of acetylcholine receptors during differentiation of a myogenic cell line. | acquisition of acetylcholine receptors during differentiation of a clonal myoblast cell line was monitored with a neurotoxin isolated from venom of the indian cobra naja naja. toxin bound specifically and reversibly to acetylcholine receptors of the differentiated cells. specificity of the binding reaction was assayed by measurement of the ability of various cholinergic agonists and antagonists to compete with neurotoxin for its binding site. the rate of toxin binding paralleled the rate of inac ... | 1972 | 4507600 |
| [the effect of the venom on the central asian cobra naja naja oxiana on tyrosine-c-14 incorporation in the cellular structures of mouse liver]. | 1974 | 4462296 |