Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| immunogenecity of hepatitis a and b vaccination in pediatric patients with inflammatory bowel disease. | aim of the study was to evaluate the response to hepatitis a and b vaccination in pediatric patients with inflammatory bowel disease (ibd). | 2013 | 23841120 |
| synthesis and biological evaluation of bis-imidazolidineiminothiones: a comparative study. | a series of 15 novel symmetrical and non-symmetrical bis-imidazolidineiminothiones (6a-g, 7a-e, 8a,b, and 9) with various substituents at n-(1) (p-tolyl, p-methoxyphenyl, p-ethoxyphenyl, p-chlorophenyl, p-bromophenyl, p-iodophenyl, and 3,5-dichlorophenyl) and different linkers between the n-(3) atoms [4,4'-oxybis(4,1-phenylene), 2,2'-dimethoxybiphenyl, and (1,3,3-trimethylcyclohexyl)methyl)] were prepared in 65-75% yields from substituted n-arylcyanothioformanilides and various bis-isocyanates. ... | 2013 | 23836516 |
| genotypic shift of the hepatitis a virus and its clinical impact on acute hepatitis a in korea: a nationwide multicenter study. | the genotypic shift of hepatitis a virus (hav) and its correlation with clinical course has not been evaluated in acute hepatitis a (aha). | 2013 | 23826788 |
| prevalence of antibodies against hepatitis a virus among children and adolescents in germany. | since hepatitis a virus (hav) infection during childhood is mostly asymptomatic, only seroprevalence studies can provide reliable information on incidence of hav infection in children. the prevalence of anti-hav antibodies was determined in sera taken in 2008 to 2010 from 1,645 children aged 0-17 years and in sera taken in 2010-2011 from 400 adult blood donors in germany. for examination of trend over time, 715 sera collected between 1999 and 2006 from children at the age of 0-17 years within th ... | 2013 | 23812435 |
| acute hepatitis in israeli travelers. | acute hepatitis is a well-described cause of morbidity and sporadic mortality in travelers. data regarding the epidemiology of hepatitis in travelers are lacking. the aim of this study is to describe the epidemiology of acute viral hepatitis among travelers returning from tropical countries, with particular attention to enterically transmitted hepatitis. | 2013 | 23809073 |
| validation of virus nat for hiv, hcv, hbv and hav using post-mortal blood samples. | commercial available nat systems are usually not validated for screening of post-mortem blood samples. nat testing might be challenging due to inhibitory substances in the cadaveric blood sample that cause false-negative test results. validation studies have to be performed to show the performance characteristics of the nat assays for testing cadaveric blood. | 2012 | 23801525 |
| novel single-step multiplex real-time polymerase chain reaction assay for simultaneous quantification of hepatitis virus a, b, c, and e in serum. | viral hepatitis needs an earliest diagnosis for its proper and timely treatment. although serodiagnosis of viral hepatitis is in regular practice, however, it has certain limitations and points to alternate procedures of diagnosis. present study was designed to develop a single-step multiplex real-time polymerase chain reaction (pcr) assay for detection of hepatitis a virus (hav), hepatitis b virus (hbv), hepatitis c virus (hcv) and hepatitis e virus (hev) related nucleic acids in sera from infe ... | 2013 | 23800094 |
| hepatitis a and hepatitis b infection prevalence and associated risk factors in men who have sex with men, bangkok, 2006-2008. | despite the availability of safe and effective vaccines, little is known about prevalence and risk factors for hepatitis a (hav) and hepatitis b virus (hbv) infection among thai men who have sex with men. the prevalence of hav and hbv infection among men who have sex with men cohort in bangkok was assessed. baseline blood specimens were drawn and demographic and behavioral data were collected. bivariate and multivariate logistic regression analysis was used to analyze risk factors for prevalent ... | 2013 | 23797893 |
| shifting epidemiology of hepatitis a infection and vaccination status of children aged 6 months-12 years: time for mass vaccination. | this study was designed to determine the current age-related hepatitis a virus (hav) seroprevalance, vaccination status of children and to evaluate the epidemiological shift in hav serostatus living in tekirdağ, which is located in thrace region, the european part of turkey. | 2013 | 23795249 |
| molecular characterization of hepatitis a virus isolated from acute infections in turkey. | background/aims:hepatitis a virus is a global public health problem, especially in developing countries, and the most common cause of hepatitis in childhood. hepatitis a virus is a single- stranded positive rna virus subdivided to 6 genotypes (3 human,3 simian). the aim of this study was to determine the prevalent genotype in turkey using sera of acute hepatitis a virus-infectedpatients from different geographical regions of the country. materials and methods:sera of 137 patients with acute hepa ... | 2012 | 23794310 |
| single-dose administration of inactivated hepatitis a vaccination in the context of hepatitis a vaccine recommendations. | our objective was to identify evidence on the protection achieved by single-dose use of inactivated hepatitis a vaccines in order to evaluate the potential of a flexible booster administration in the form of a second dose. | 2013 | 23791857 |
| humoral immunity and delayed-type hypersensitivity in healthy subjects treated for 30 days with mk-7123, a selective cxcr2 antagonist. | antagonism of the chemokine receptor cxcr2 inhibits neutrophil trafficking and may thus be therapeutic in patients with chronic obstructive pulmonary disease and other lung disorders in which there is substantial infiltration by neutrophils. here, we report the findings from a randomized, placebo-controlled, double-blind clinical trial of the small-molecule cxcr2 antagonist mk-7123 (formerly sch 527123) that evaluated potential downstream effects of cxcr2 antagonism on immunogenic competency (b ... | 2013 | 23791619 |
| acute liver disease in japan: a nationwide analysis of the japanese diagnosis procedure combination database. | accurate data on the incidence of acute liver disease (ald) is lacking in most countries. we investigated the incidence of ald-related admission in japan using a large sample in a nationwide japanese database. | 2014 | 23783841 |
| factors associated with the immune response to hepatitis a vaccination in hiv-infected patients in the era of highly active antiretroviral therapy. | hiv seropositivity is considered a risk factor for complications in hepatitis a virus (hav) infection. hav vaccination schedules are widely implemented in hiv-infected patients, but the immune response remains impaired. | 2013 | 23777950 |
| risk factors for acute hepatitis a infection in korea in 2007 and 2009: a case-control study. | this study aimed to identify the risk factors associated with acute hepatitis a virus (hav) infection in the korean population. participants were recruited from five referral hospitals across the country in 2007 and from 11 hospitals in 2009. patients with positive anti-hav igm antibody tests became the case group, while patients treated for non-contagious diseases at the same hospitals were recruited as controls. a total of 222 and 548 case-control pairs were studied in the 2007 and 2009 survey ... | 2013 | 23772157 |
| low level of immunity against hepatitis a among korean adolescents: vaccination rate and related factors. | we evaluated the current vaccination rate and immunity in the korean adolescent population and analyzed their parents' attitudes toward hepatitis a virus (hav) vaccination. | 2013 | 23769832 |
| impact of hpv16/18 vaccination on quality of life: a pilot study. | genital human papillomavirus (hpv) infections and associated precancerous lesions adversely affect health-related quality of life (hrqol). hpv vaccines provide effective protection against these conditions. we therefore investigated the impact of hpv vaccination on hrqol in young women five years after participation in a phase iii hpv vaccination trial. | 2013 | 23768267 |
| development and evaluation of a pseudovirus-luciferase assay for rapid and quantitative detection of neutralizing antibodies against enterovirus 71. | the level of neutralizing antibodies (ntab) induced by vaccine inoculation is an important endpoint to evaluate the efficacy of ev71 vaccine. in order to evaluate the efficacy of ev71 vaccine, here, we reported the development of a novel pseudovirus system expression firefly luciferase (pvla) for the quantitative measurement of ntab. we first evaluated and validated the sensitivity and specificity of the pvla method. a total of 326 serum samples from an epidemiological survey and 144 serum speci ... | 2013 | 23755115 |
| changes in the balance between treg and th17 cells in patients with chronic hepatitis b. | the purpose of this study was to explore the role of treg cells, th17 cells and cytokines associated with treg/th17 differentiation in the occurrence, development and outcome of chronic hepatitis b (chb). to do so, we detected populations of treg and th17 cells and their associated cytokines in the peripheral blood of chb patients. the populations of treg cells (cd4(+)cd25(high)cd127(low) t cells) and th17 cells (cd3(+)cd8(-)il-17(+) t cells) were analyzed in 46 patients with low to moderate chr ... | 2013 | 23747030 |
| concomitant administration of hepatitis a vaccine with measles/mumps/rubella/varicella and pneumococcal vaccines in healthy 12- to 23-month-old children. | this open-label, multicenter, randomized, comparative study evaluated immunogenicity, safety and tolerability of concomitant (group 1; n=330) vs. non-concomitant (group 2; n=323) vaqta™ (25u/0.5 ml) (hepatitis a vaccine; hav) with proquad™ (measles/mumps/rubella/varicella; mmrv) and prevnar™ (7-valent pneumococcal; pcv-7) in healthy, 12-23 mo old children. group 1 received hav/mmrv/pcv-7 concomitantly on day 1 and second doses of hav/mmrv at week 24. group 2 received mmrv/pcv-7 on day 1, hav at ... | 2013 | 23744509 |
| seroprevalence and molecular characterisation of human hepatitis a virus in serum samples of tunisian patients with clinical symptoms of viral hepatitis. | the aim of the present study was to investigate the seroprevalence of hepatitis a virus antibodies in patients with clinical symptoms of viral hepatitis and molecular characterization of the detected isolates. the present study deals with the seroprevalence and the genetic diversity of hav in 400 tunisian patients presenting in dispensaries (160 patients) and in university hospitals (240 patients) with hepatitis symptoms between 2006 and 2008. the patients with acute hepatitis were mainly from r ... | 2012 | 23729999 |
| antibody-secreting cells with a phenotype of ki-67low, cd138high, cd31high, and cd38high secrete nonspecific igm during primary hepatitis a virus infection. | although studies investigating the nature of ab-secreting cells (ascs) during acute infection with influenza or dengue virus found that the asc response was dominated by virus-specific igg secretion, the ag specificity and phenotype of ascs during primary acute viral infection were not identified. to this end, we investigated the nature of ascs in direct ex vivo assays from patients with acute hepatitis a caused by primary infection with hepatitis a virus (hav). we found that the frequency of cd ... | 2013 | 23729443 |
| virus inactivation on hard surfaces or in suspension by chemical disinfectants: systematic review and meta-analysis of norovirus surrogates. | norovirus (nov) infections are the leading cause of foodborne illness in the united states. effective disinfection is important for controlling outbreaks caused by this highly infectious virus but can be difficult to achieve because nov is very resistant to many common disinfection protocols. the inability of human nov to replicate in tissue culture complicates nov research, generally necessitating genome copy quantification, the use of surrogate viruses, or the use of other substitutes such as ... | 2013 | 23726196 |
| molecular biology and inhibitors of hepatitis a virus. | hepatitis a virus (hav) is a faeco-orally transmitted picornavirus and is one of the main causes of acute hepatitis worldwide. an overview of the molecular biology of hav is presented with an emphasis on recent findings. immune evasion strategies and a possible correlation between hav and atopy are discussed as well. despite the availability of efficient vaccines, antiviral drugs targeting hav are required to treat severe cases of fulminant hepatitis, contain outbreaks, and halt the potential sp ... | 2014 | 23722879 |
| acute hepatitis a virus infections in british gurkha soldiers. | hepatitis a virus (hav) and hepatitis e virus (hev) infections are endemic in most developing countries, including nepal and afghanistan, and may cause outbreaks in military personnel. previously, more than 99% of new british gurkha recruits were already immune to hav because of prior infection, but this may be declining due to improved living conditions in their countries of origin. acute hav infections have occurred in gurkha soldiers serving in afghanistan, which made them unfit for duty for ... | 2013 | 23720504 |
| genomic copy concentrations of selected waterborne viruses in a slum environment in kampala, uganda. | the presence of viruses in a slum environment where sanitation is poor is a major concern. however, little is known of their occurrence and genomic copy concentration in the slum environment. the main objective of this study was to determine the genomic copy concentrations of human adenoviruses f and g, rotavirus (rv), hepatitis a virus (hav), hepatitis e virus (hev) and human adenovirus species a,c,d,e, and f (hadv-acdef) in bwaise iii, a typical slum in kampala, uganda. forty-one samples from ... | 2013 | 23708582 |
| [epidemiology of hepatitis a, b, and c among adults in germany: results of the german health interview and examination survey for adults (degs1)]. | ten years after seroepidemiological data were obtained in the german national health interview and examination survey 1998 (gnhies98), german health interview and examination survey (degs1) data contribute to a population-based, representative surveillance of hepatitis a and b immunity and of the serological markers for hepatitis c in germany. the prevalence of antibodies against the hepatitis a virus is 48.6 %. in comparison to the situation 10 years ago, seroprevalence is significantly higher ... | 2013 | 23703489 |
| comparison of two extraction methods for the detection of hepatitis a virus in lettuces using the murine norovirus as a process control. | enteric viruses are important agents of foodborne diseases. in recent years, raw fruits and vegetables have frequently been involved in foodborne transmission of enteric viruses to humans, particularly noroviruses and hepatitis a virus (hav). although viral contamination can occur at any stage of food processing, primary production is a critical stage in which prevention measures are essential to minimise the risk of infection to consumers. due to the low infectious doses and low concentrations ... | 2013 | 23702026 |
| computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis. | to evaluate the significance of computed tomography (ct) findings in relation to liver chemistry and the clinical course of acute hepatitis. | 2013 | 23674857 |
| [prevalence of antibodies to hepatitis a virus in healthcare workers and associated variables]. | vaccination against hepatitis a is recommended in risk groups, including healthcare workers. the objective of this study was to determine the prevalence of antibodies to hav (igg) among workers in the healthcare setting in order to establish criteria for vaccination. | 2016 | 23669502 |
| [the new microbiological hazards in food]. | this paper describes the new microbiological hazards in food. for protecting human health, nowadays food safety authorities face with many challenges, that years ago were largely unheard. in 2011 verocytotoxigenic escherichia coli o104:h4 has been isolated in germany. strain came from fenugreek sprouts originated from egypt. it was characterized by unique features such as presence of enteroaggregative escherichia coli genes (aata, aggr, aap, agga, aggc) and resistance to most antibiotics. in pol ... | 2012 | 23631259 |
| seroepidemiology of hepatitis a in south korea: a nationwide study by the eone reference laboratory. | we evaluated the recent prevalence of serologic markers of hepatitis a virus (hav) in south korea. | 2013 | 23629647 |
| inactivation of food-borne viruses using natural biochemical substances. | food-borne viruses such as human noroviruses (novs), hepatitis a virus (hav), rotaviruses (rovs) are a public health concern worldwide. biochemical substances, which occur naturally in plants, animals or microorganisms, might possess considerable antimicrobial properties. in this study, the reported effects of biochemical substances on food-borne viruses are reviewed. the biochemical substances are grouped into several categories including (i) polyphenols and proanthocyanins, (ii) saponin, (iii) ... | 2013 | 23628607 |
| [detection of hepatitis a virus rna with an improved loop-mediated isothermal amplification assay]. | to establish a novel improved loop-mediated isothermal amplification (lamp) technique to detect hepatitis a virus (hav). | 2012 | 23627037 |
| [hepatitis a virus mimotope mapping by phage display peptide library]. | a 12 mer phage display peptide library was used to identify hepatitis a virus mimotopes of antigenic determinants, to provide the feasibility of virus epitope mapping by using this approach. | 2012 | 23627029 |
| improved duplex rt-pcr assay for differential diagnosis of mixed infection of duck hepatitis a virus type 1 and type 3 in ducklings. | infection with duck hepatitis a virus (dhav) causes an acute, rapidly spreading, and fatal disease of young ducklings. dhav type 1 (dhav-1) and type 3 (dhav-3) have been identified in china. in this study, a duplex rt-pcr assay was developed to identify dhav-1 and dhav-3 with mixed infection. the method was shown to be high specificity and sensitivity. the minimum detection limit of the method has been determined to be 10pg total rna templates extracted from duck liver samples or 10² copies vira ... | 2013 | 23624117 |
| viral outbreaks in neonatal intensive care units: what we do not know. | nosocomial infection is among the most important causes of morbidity, prolonged hospital stay, increased hospital costs, and mortality in neonates, particularly those born preterm. the vast majority of scientific articles dealing with nosocomial infections address bacterial or fungal infections, and viral agents are often disregarded. this analysis reviews the medical literature in an effort to establish the incidence, types of pathogens, and clinical features of noncongenital neonatal viral inf ... | 2013 | 23623159 |
| are liver transplant recipients protected against hepatitis a and b? | liver transplant recipients are at an increased risk for liver failure when infected with hepatitis a virus (hav) and hepatitis b virus (hbv). therefore, it is important to vaccinate these individuals. the aim of the study was to evaluate how well liver transplanted patients in our unit were protected against hav and hbv infection. furthermore we investigated the vaccination rate and the antibody response to vaccination in these liver transplanted patients. | 2013 | 23622657 |
| prevalence of hepatitis a virus in bivalve molluscs sold in granada (spain) fish markets. | viruses are the leading cause of foodborne illness associated with the consumption of raw or slightly cooked contaminated shellfish. the aim of this study was to evaluate the prevalence of hepatitis a virus in molluscs. standard and real-time reverse transcription-polymerase chain reaction procedures were used to monitor bivalve molluscs from the granada fish markets (southern spain) for this human enteric virus. between february 2009 and october 2010, we collected a total of 329 samples of diff ... | 2013 | 23614798 |
| full genome analysis of philippine indigenous subgenotype ia hepatitis a virus strains from japanese patients with imported acute hepatitis a. | hepatitis a virus (hav) is the most common cause of infectious hepatitis worldwide. although hepatitis a cases imported from south-east asian countries, including the philippines, have been reported in japan, the molecular epidemiological data have been limited for these hav-endemic countries. | 2014 | 23607583 |
| clinical presentation, outcome, and response to therapy among patients with acute exacerbation of chronic hepatitis c. | the slow asymptomatic progression of chronic hepatitis c (chc) can be interrupted by an acute exacerbation, characterized by increased serum levels of alanine aminotransferase (alt) and bilirubin and other symptoms of acute hepatitis. we aimed to provide more information about the clinical presentation of acute exacerbation of chc. | 2013 | 23591280 |
| susceptibility of murine norovirus and hepatitis a virus to electron beam irradiation in oysters and quantifying the reduction in potential infection risks. | consumption of raw oysters is an exposure route for human norovirus (nov) and hepatitis a virus (hav). therefore, efficient postharvest oyster treatment technology is needed to reduce public health risks. this study evaluated the inactivation of hav and the nov research surrogate, murine norovirus-1 (mnv-1), in oysters (crassostrea virginica) by electron beam (e-beam) irradiation. the reduction of potential infection risks was quantified for e-beam irradiation technology employed on raw oysters ... | 2013 | 23584781 |
| high yield expression of duck hepatitis a virus vp1 protein in escherichia coli, and production and characterization of polyclonal antibody. | vp1 protein, the capsid protein of duck hepatitis a virus (dhav), contains critical epitopes for inducing a protective immune response. due to its low-level expression in escherichia coli (e. coli), the function of this protein is poorly characterized. in this study, a codon-optimized vp1 gene was chemically synthesized in terms of the codon usage bias in e. coli and subcloned into pet32a (+) to increase its expression. the recombinant vp1 fusion protein was purified from inclusion body by ni(2+ ... | 2013 | 23583731 |
| development of a new cell culture-based method and optimized protocol for the detection of enteric viruses. | the development of rapid and effective methods to detect water- and food-borne enteric viruses is important for the prevention and control of mass infection. this study represents an attempt to develop a reliable cell culture-based detection system and optimize an effective and rapid protocol for the assaying of environmental samples for the presence of infectious enteric viruses. six enteric viruses were used in this study: poliovirus, coxsackie virus a9, coxsackie virus b5, human rotavirus g1, ... | 2013 | 23578702 |
| epidemiological investigation of an outbreak of hepatitis a at a residential facility for the disabled, 2011. | an outbreak of hepatitis a occurred at a residential facility for the disabled in july 10, 2011. this investigation was carried out to develop a response plan, and to find the infection source of the disease. | 2013 | 23573370 |
| acbd3 interaction with tbc1 domain 22 protein is differentially affected by enteroviral and kobuviral 3a protein binding. | despite wide sequence divergence, multiple picornaviruses use the golgi adaptor acyl coenzyme a (acyl-coa) binding domain protein 3 (acbd3/gcp60) to recruit phosphatidylinositol 4-kinase class iii beta (pi4kiiiβ/pi4kb), a factor required for viral replication. the molecular basis of this convergent interaction and the cellular function of acbd3 are not fully understood. using affinity purification-mass spectrometry, we identified the putative rab33 gtpase-activating proteins tbc1d22a and tbc1d22 ... | 2013 | 23572552 |
| comparative evaluation of a novel taqman real-time reverse transcription-polymerase chain reaction assay for hepatitis a virus detection. | to develop and evaluate a novel system for detecting and quantifying hepatitis a virus (hav) nucleic acid. | 2013 | 23569019 |
| escherichia coli, salmonella spp., hepatitis a virus and norovirus in bivalve molluscs in southern italy. | european legislation has fixed microbiological, chemical and biotoxicological limits for shellfish but no limits for viruses. in the present study we report the results of an investigation on salmonella spp., escherichia coli, hepatitis a virus (hav) and norovirus (nov) contamination in 59 bivalve shellfish collected during the years 2011-2012 in southern italy. all the samples of mytilus galloprovincialis and of solen marginatus were negative for hav whereas 6.8% of them were positive for norov ... | 2013 | 23564588 |
| genetic characterization of a novel picornavirus in turkeys (meleagris gallopavo) distinct from turkey galliviruses and megriviruses and distantly related to the members of the genus avihepatovirus. | this study reports the metagenomic detection and complete genome characterization of a novel turkey picornavirus from faecal samples of healthy (1/3) and affected (6/8) commercial turkeys with enteric and/or stunting syndrome in hungary. the virus was detected at seven of the eight farms examined. the turkey/m176-tuasv/2011/hun genome (kc465954) was genetically different from the currently known picornaviruses of turkey origin (megriviruses and galliviruses), and showed distant phylogenetic rela ... | 2013 | 23559479 |
| case of acute hepatitis e with concomitant signs of autoimmunity. | sporadic cases of acute viral hepatitis e have been described in developed countries, despite the more common occurrence in endemic areas and developing countries. we present the case of a 58 years old portuguese female, with no epidemiological relevant factors, admitted with acute hepatitis with positive anti-nuclear antibodies, anti-smooth muscle antibody and high serum gamma globulin (> 1.5 fold increase). serologies for hepatitis a virus, hepatitis b virus, hepatitis c virus, epstein-barr vi ... | 2013 | 23556050 |
| tim-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. | human t-cell immunoglobulin and mucin-domain containing proteins (tim1, 3, and 4) specifically bind phosphatidylserine (ps). tim1 has been proposed to serve as a cellular receptor for hepatitis a virus and ebola virus and as an entry factor for dengue virus. here we show that tim1 promotes infection of retroviruses and virus-like particles (vlps) pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, new world arenavirus and alphavirus families. tim ... | 2013 | 23555248 |
| a pathogenic picornavirus acquires an envelope by hijacking cellular membranes. | animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and immune recognition. among those lacking an envelope, the picornaviridae are a large and diverse family of positive-strand rna viruses that includes hepatitis a virus (hav), an ancient human pathogen that remains a common cause of enterically transmitted hepatitis. hav infects in a stealth-like manner and ... | 2013 | 23542590 |
| rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis a replication. | three different antiviral assays were developed for the in vitro screening of inhibitors of the hepatitis a virus (hav) of which (i) a cytopathic effect reduction assay suitable for medium-to-high-throughput screening and (ii) two virus yield reduction assays (based on quantification of viral rna) for genotypes ib and iiia. the assays were validated for antiviral studies with interferon-alpha (ifnα) and amantadine hcl, two known inhibitors of hav replication. ifnα effectively inhibited hav repli ... | 2013 | 23528258 |
| hepatitis a vaccination coverage among adults 18-49 years traveling to a country of high or intermediate endemicity, united states. | since 1996, hepatitis a vaccine (hepa) has been recommended for adults at increased risk for infection including travelers to high or intermediate hepatitis a endemic countries. in 2009, travel outside the united states and canada was the most common exposure nationally reported for persons with hepatitis a virus (hav) infection. | 2013 | 23523408 |
| outbreaks associated to large open air festivals, including music festivals, 1980 to 2012. | in the minds of many, large scale open air festivals have become associated with spring and summer, attracting many people, and in the case of music festivals, thousands of music fans. these festivals share the usual health risks associated with large mass gatherings, including transmission of communicable diseases and risk of outbreaks. large scale open air festivals have however specific characteristics, including outdoor settings, on-site housing and food supply and the generally young age of ... | 2013 | 23517872 |
| birth cohort screening for chronic hepatitis during colonoscopy appointments. | more than 70% of infections with hepatitis c viruses (hcv) occur among people born between 1945 and 1965 (baby boomers). the us centers for disease control estimate that 70% of people with chronic hepatitis are not aware that they are infected with a virus. we performed a prospective trial to determine whether people born during this time period would accept testing for chronic viral infection (hepatitis b virus (hbv) and hcv) during routine colonoscopies. we also evaluated acceptance and effica ... | 2013 | 23511461 |
| the role of surface functionalization of colloidal alumina particles on their controlled interactions with viruses. | materials that interact in a controlled manner with viruses attract increasing interest in biotechnology, medicine, and environmental technology. here, we show that virus-material interactions can be guided by intrinsic material surface chemistries, introduced by tailored surface functionalizations. for this purpose, colloidal alumina particles are surface functionalized with amino, carboxyl, phosphate, chloropropyl, and sulfonate groups in different surface concentrations and characterized in t ... | 2013 | 23498895 |
| grape seed extract for foodborne virus reduction on produce. | grape seed extract (gse) is reported to have antibacterial properties with few current studies on antiviral activity. recently, we reported the effects of gse against foodborne viral surrogates in vitro. this study evaluated the application of gse (commercial gravinol-s) against hepatitis a virus (hav) and human norovirus surrogates, feline calicivirus (fcv-f9) and murine norovirus (mnv-1), on model produce. washed and air-dried lettuce (3 × 3 cm(2)) and jalapeno peppers (25-30 g) were inoculate ... | 2012 | 23498171 |
| effects of an ageing population and the replacement of immune birth cohorts on the burden of hepatitis a in the netherlands. | in populations in which the incidence of hepatitis a virus (hav) infection has declined due to socio-economic improvements, better sanitation and hygiene, and vaccination, birth cohorts who have long-term immunity through exposure early in life are now being replaced by non-immune cohorts, meaning that more cases in the elderly may occur in future. our goal was to qualitatively investigate the interaction of this cohort effect and demographic change (population ageing) on the estimated disease b ... | 2013 | 23497182 |
| comparison of 3 automated immunoassays for detection of anti-hepatitis a virus immunoglobulin m in a tertiary care hospital. | three automated immunoassay kits for anti-hepatitis a virus (hav) igm-architect, (abbott laboratories, usa), elecsys (roche diagnostics, germany), and advia centaur (siemens healthcare diagnostics inc., usa)-were compared. we included 178 consecutive samples, for which an anti-hav igm test was requested at seoul national university hospital from september 2009 to january 2010. reviewing of medical records, reverse transcription (rt)-pcr for hav rna, or total anti-hav assay were performed on 16 ( ... | 2013 | 23483019 |
| detection and characterization of hepatitis a virus and norovirus in mussels from galicia (nw spain). | shellfish are recognized as a potential vehicle of viral disease and despite the control measures for shellfish safety there is periodic emergence of viral outbreaks associated with shellfish consumption. in this study a total of 81 mussel samples from ría do burgo, a coruña (nw spain) were analysed. samples were collected in seven different harvesting areas with the aim to establish a correlation between the prevalence of norovirus (nov) and hepatitis a virus (hav) in mussel samples and the wat ... | 2013 | 23471578 |
| reproducibility, fidelity, and discriminant validity of linear rna amplification for microarray-based identification of major human enteric viruses. | human enteric viruses are inherently a group of viruses that confer similar or overlapping clinical symptoms and pose a challenge for correct etiological diagnosis. dna microarray technology has emerged to be of major interest to detect broad range of viral pathogens including enteric viruses. however, this approach requires a relative large amount of target nucleic acid for hybridization analysis. this feature limits its further applicability. to address this challenge, we evaluated a novel sin ... | 2013 | 23455564 |
| the efficiency of concentration methods used to detect enteric viruses in anaerobically digested sludge. | the presence of enteric viruses in biosolids can be underestimated due to the inefficient methods (mainly molecular methods) used to recover the viruses from these matrices. therefore, the goal of this study was to evaluate the different methods used to recover adenoviruses (adv), rotavirus species a (rva), norovirus genogroup ii (nov gii) and the hepatitis a virus (hav) from biosolid samples at a large urban wastewater treatment plant in brazil after they had been treated by mesophilic anaerobi ... | 2013 | 23440119 |
| detection of replication-defective hepatitis a virus based on the correlation between real-time polymerase chain reaction and elisa in situ results. | elisa in situ can be used to titrate hepatitis a virus (hav) particles and real-time polymerase chain reaction (rt-pcr) has been shown to be a fast method to quantify the hav genome. precise quantification of viral concentration is necessary to distinguish between infectious and non-infectious particles. the purpose of this study was to compare cell culture and rt-pcr quantification results and determine whether hav genome quantification can be correlated with infectivity. for this purpose, thre ... | 2013 | 23440112 |
| acute pancreatitis complicating acute hepatitis a virus infection. | acute pancreatitis complicating acute hepatitis a is very rare especially in children. we report here an 11 year old female patient with picture of acute hepatitis proved to be caused by hepatitis a. one week later patient's condition worsened, she was jaundiced, with persistent vomiting and looked acutely ill and uncomfortable with severe steady abdominal pain mainly in the epigastrium and upper quadrants. acute pancreatitis was suspected and proved by a clinical picture associated with elevate ... | 2012 | 23432988 |
| [surveillance of viral hepatitis: laboratory results. cuba, 1992-2004]. | the results of the surveillance of the viral hepatitis in the period 1992-2004 are presented. the hav infection is the most frequent association that originates pictures of acute viral hepatitis among the patients under 24 years old with positive hbsag, followed by the hepatitis b virus. the hepatitis a virus alone or co-infected with the hepatitis b virus accounts for 48.88% of the cases. only 48.71% of the cases among whom acute hepatitis b is suspected, are confirmed from the virological poin ... | 2013 | 23427426 |
| harmonised investigation of the occurrence of human enteric viruses in the leafy green vegetable supply chain in three european countries. | numerous outbreaks have been attributed to the consumption of raw or minimally processed leafy green vegetables contaminated with enteric viral pathogens. the aim of the present study was an integrated virological monitoring of the salad vegetables supply chain in europe, from production, processing and point-of-sale. samples were collected and analysed in greece, serbia and poland, from 'general' and 'ad hoc' sampling points, which were perceived as critical points for virus contamination. gene ... | 2012 | 23412890 |
| potential risk of norovirus infection due to the consumption of "ready to eat" food. | in this study, we investigated the presence of enteric viruses such as norovirus (nov), hepatitis a virus (hav), hepatitis e virus (hev), and adenovirus (hadv), in vegetables available on the italian markets. for this aim, 110 national and international "ready to eat" samples were collected and analyzed by biomolecular tests and positive samples were confirmed by sequencing. all samples (100 %) were negative for hav, hev, and hadv, while 13.6 % (15/110) were positive for nov. actually there is n ... | 2012 | 23412835 |
| occurrence of human enteric viruses in commercial mussels at retail level in three european countries. | in this study, the prevalence of different enteric viruses in commercial mussels was evaluated at the retail level in three european countries (finland, greece and spain). a total of 153 mussel samples from different origins were analysed for human norovirus (nov) genogroups i and ii, hepatitis a virus (hav) and hepatitis e virus (hev). human adenovirus (hadv) was also tested as an indicator of human faecal contamination. a full set of controls (such as sample process control, internal amplifica ... | 2012 | 23412813 |
| comparative analysis of viral concentration methods for detecting the hav genome using real-time rt-pcr amplification. | hepatitis a is a major infectious disease epidemiologically associated with foodborne and waterborne outbreaks. molecular detection using real-time rt-pcr to detect the hepatitis a virus (hav) in contaminated vegetables can be hindered by low-virus recoveries during the concentration process and by natural pcr inhibitors in vegetables. this study evaluated three virus concentration methods from vegetables: polyethylene glycol (peg) precipitation, ultrafiltration (uf), and immunomagnetic separati ... | 2012 | 23412812 |
| discrimination of infectious hepatitis a viruses by propidium monoazide real-time rt-pcr. | the discrimination of infectious and inactivated viruses remains a key obstacle when using quantitative rt-pcr (rt-qpcr) to quantify enteric viruses. in this study, propidium monoazide (pma) and rnase pretreatments were evaluated for the detection and quantification of infectious hepatitis a virus (hav). for thermally inactivated hav, pma treatment was more effective than rnase treatment for differentiating infectious and inactivated viruses, with hav titers reduced by more than 2.4 log(10) unit ... | 2011 | 23412764 |
| detecting hepatitis e virus with a reverse transcription polymerase chain reaction enzyme-linked immunosorbent assay. | this study aimed to develop a specific and sensitive reverse transcription polymerase chain reaction enzyme-linked immunosorbent assay (rt-pcr-elisa) for detecting hepatitis e virus (hev). eight sets of primers and biotinylated probes designed in the orf2-orf3 overlapping region of hev were tested for sensitivity. the ability of nested reverse transcription polymerase chain reaction (rt-pcr) and rt-pcr-elisa to detect hev was compared. rt-pcr-elisa was 10-100 times more sensitive than nested rt- ... | 2011 | 23412763 |
| the fate of murine norovirus and hepatitis a virus during preparation of fresh produce by cutting and grating. | human noroviruses and hepatitis a virus (hav) are commonly associated with outbreaks occurring in restaurant establishments and catered events. food handlers are major contributing factors to foodborne illnesses initiated in the kitchen setting. in this study, transfer of hav and murine norovirus (mnv-1), a human norovirus surrogate, between produce (cucumbers, strawberries, tomatoes, cantaloupes, carrots, and honeydew melons) and common kitchen utensils (graters and knives) was investigated. th ... | 2012 | 23412721 |
| shellfish-borne viral outbreaks: a systematic review. | investigations of disease outbreaks linked to shellfish consumption have been reported in the scientific literature; however, only few countries systematically collate and report such data through a disease surveillance system. we conducted a systematic review to investigate shellfish-borne viral outbreaks and to explore their distribution in different countries, and to determine if different types of shellfish and viruses are implicated. six databases (medline, embase, scopus, pubmed, eurosurve ... | 2012 | 23412719 |
| norovirus and other human enteric viruses in moroccan shellfish. | the aim of this study was to evaluate the presence of human enteric viruses in shellfish collected along the mediterranean sea and atlantic coast of morocco. a total of 77 samples were collected from areas potentially contaminated by human sewage. noroviruses were detected in 30 % of samples, with an equal representation of gi and gii strains, but were much more frequently found in cockles or clams than in oysters. the method used, including extraction efficiency controls, allowed the quantifica ... | 2013 | 23412717 |
| high pressure processing and its application to the challenge of virus-contaminated foods. | high pressure processing (hpp) is an increasingly popular non-thermal food processing technology. study of hpp's potential to inactivate foodborne viruses has defined general pressure levels required to inactivate hepatitis a virus, norovirus surrogates, and human norovirus itself within foods such as shellfish and produce. the sensitivity of a number of different picornaviruses to hpp is variable. experiments suggest that hpp inactivates viruses via denaturation of capsid proteins which render ... | 2012 | 23412716 |
| comparative uptake of enteric viruses into spinach and green onions. | root uptake of enteric pathogens and subsequent internalization has been a produce safety concern and is being investigated as a potential route of pre-harvest contamination. the objective of this study was to determine the ability of hepatitis a virus (hav) and the human norovirus surrogate, murine norovirus (mnv), to internalize in spinach and green onions through root uptake in both soil and hydroponic systems. hav or mnv was inoculated into soil matrices or into two hydroponic systems, float ... | 2012 | 23412715 |
| construction, expression and immunogenicity of a novel anti-hypertension angiotensin ii vaccine based on hepatitis a virus-like particle. | hypertension is a serious worldwide public health problem. the aim of this study is to design anti-hypertension angiotensin ii (ang ii) vaccine using molecular biology and immunological method. this novel anti-hypertension vaccine, which is a chimeric protein named phav-4ang iis, presents four successive repeated ang iis as the functional epitope on the surface of the hepatitis a virus-like particle(havlp). in this study, phav-4ang iis was expressed using bac-to-bac baculovirus expression system ... | 2013 | 23412424 |
| etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in japan: summary of the annual nationwide survey between 2004 and 2009. | to summarize the annual nationwide survey on fulminant hepatitis (fh) and late-onset hepatic failure (lohf) between 2004 and 2009 in japan. | 2013 | 23409848 |
| viral genes everywhere: public health implications of pcr-based testing of foods. | food borne viruses such as norovirus and hepatitis a virus are increasingly recognized worldwide as the most important cause of food borne gastro-intestinal illness. food borne outbreaks, often involving multiples cases, have been reported and associated with food products of both animal and non-animal origin. most foods are contaminated with food borne viruses during preparation and service. however, bivalve molluscs and occasionally produce (in particular leafy vegetables and soft red fruits) ... | 2013 | 23403207 |
| declining incidence of hepatitis a in amsterdam (the netherlands), 1996-2011: second generation migrants still an important risk group for virus importation. | the netherlands is a very low endemic country for hepatitis a virus infections (hav, notification rate of <1/100,000). historically in amsterdam, a large proportion of infections are imported from turkey and morocco in children returning from summer holiday. annually since 1998, the public health service of amsterdam has targeted these children for hav vaccination before the summer. as the population of non-western immigrants and their descendents increases, we describe recent trends in hav in e ... | 2013 | 23395735 |
| expression of a hepatitis a virus antigen in lactococcus lactis and escherichia coli and evaluation of its immunogenicity. | an epidemic shift in hepatitis a virus (hav) infection has been observed in recent years in rapidly developing countries, with increasing numbers of severe adult cases which has led to renewed interest in vaccination. our approach in vaccine development uses recombinant expression of the highly immunogenic hav antigen vp1-p2a in food-grade lactic acid bacterium lactococcus lactis and in escherichia coli. we used genetic constructs that enable nisin-controlled expression of the antigen in l. lact ... | 2013 | 23371298 |
| hepatitis a virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis a virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression. | to correlate hepatitis a virus cellular receptor (havcr)/kidney injury molecule-1 (kim-1) expression in clear cell renal cell carcinoma (ccrcc) tumours with patient outcome and study the consequences of havcr/kim-1 ectodomain shedding. | 2013 | 23352434 |
| development of a rapid total nucleic acid extraction method for the isolation of hepatitis a virus from fresh produce. | recently, there have been increasing reports of foodborne illnesses associated with the consumption of fresh produce. among these, hepatitis a virus (hav) remains epidemiologically important and has been continually implicated in several outbreaks. we describe a rapid method (<8h) for the isolation and subsequent detection with real-time quantitative pcr (rt-qpcr) of the hav hm-175 cytopathic strain seeded onto baby spinach and sliced tomatoes using a total rna extraction method, utilizing a hig ... | 2012 | 23334093 |
| kinetics of maternally acquired anti-hepatitis a antibodies: prediction of waning based on maternal or cord blood antibody levels. | timing is critical for efficient hepatitis a vaccination in high endemic areas as high levels of maternal igg antibodies against the hepatitis a virus (hav) present in the first year of life may impede the vaccine response. | 2013 | 23328312 |
| window period of anti-hepatitis a virus immunoglobulin m antibodies in diagnosing acute hepatitis a. | the diagnosis of acute hepatitis a virus (hav) infection is made on the basis of the presence of anti-hav immunoglobulin m (igm) antibodies in patients with clinical features of acute hepatitis. some patients show a negative serology at initial presentation, which may complicate the diagnosis of hepatitis a (ha). the aim of this study was to examine the characteristics of ha patients with an initially negative anti-hav igm test result. | 2013 | 23325281 |
| high prevalence of anti-hepatitis a virus immunoglobulin g antibody among healthcare facility attendees in osogbo, nigeria. | the objectives of this study were to determine the prevalence of anti-hepatitis a virus (hav) immunoglobulin g (igg) antibody and associated factors among residents of osogbo, a town in nigeria with inadequate environmental sanitation and a shortage of potable water. this is a health facility-based study. ninety one consenting, asymptomatic attendees of public healthcare facilities in osogbo, osun state, nigeria, were consecutively selected for this study. plasma samples of the study participant ... | 2013 | 23323983 |
| multiplex polymerase chain reaction test for the diagnosis of acute viral hepatitis a. | the early diagnosis of acute hepatitis a (aha) is hindered because serum igm against hepatitis a virus (hav) can yield false-negative results during the window period. this study evaluated the diagnostic accuracy of a polymerase chain reaction (pcr) kit for hav rna for the diagnosis of aha. | 2012 | 23323256 |
| physical removal and transfer of murine norovirus and hepatitis a virus from contaminated produce by scrubbing and peeling. | human noroviruses and hepatitis a virus are responsible for numerous outbreaks associated with handling fresh produce. in this study, physical removal of hepatitis a virus and murine norovirus, a human norovirus surrogate, from contaminated produce items (honeydew melons, cantaloupes, carrots, and celery) by scrubbing under running water with a nylon brush or scouring pad and by peeling (carrots and celery) with a peeler was investigated. the degree and extent of utensil contamination with virus ... | 2013 | 23317861 |
| seroprevalence of hepatitis a virus antibodies (anti-hav) in adult inhabitants of wielkopolska region, poland--the role of simple demographic factors. | based on the available epidemiologic data, poland currently has the features typical for areas of very low endemicity for hepatitis a. the incidence of hepatitis a in the wielkopolska region in years 2006-2008 was 0.68/100,000 inhabitants or significantly lower. the aim of this cross-sectional analysis was to evaluate the seroprevalence of anti-hav antibodies in inhabitants of the wielkopolska region of western poland regarding some demographic factors. | 2012 | 23311799 |
| [experience of application of multiplex qpcr for differential diagnostics of intestinal viral infections]. | evaluate the effectiveness of multiplex reverse transcription (rt) and polymerase chain reaction with fluorescence detection in real time mode (qpcr) methods for differential detection of 11 groups of intestine viruses (adenoviruses, enteroviruses, polioviruses, hepatitis a and e viruses, group a and c rotaviruses, orthoreoviruses, noroviruses, sapoviruses and astroviruses) in various biological samples. | 2012 | 23297630 |
| seroprevalence of hepatitis a virus in a cross-sectional study in mexico: implications for hepatitis a vaccination. | hepatitis a virus (hav) remains a public health concern worldwide contributing to significant morbidity in developed and developing countries. this cross-sectional database study estimated the overall hav seroprevalence and the seroprevalence by gender, age, region and socioeconomic status in mexico. between january and october 2010, serum samples collected during the national health and nutrition survey (ensanut 2006) were obtained from subjects aged 1-95 y. subjects' gender, age, geographical ... | 2013 | 23291940 |
| knowledge and attitude of dental practitioners in ta-briz regarding infection control procedures. | blood-borne infections such as hepatitis b, hepatitis c and hiv might be transmitted from one individual to another during dental procedures. therefore, sterilization and personal protection procedures are of utmost significance in dental offices. the importance of awareness of cross-infection and antiseptic principles lies in the fact that in most cases it is not possible to identify patients with hepatitis or aids. the aim of the present study was to evaluate awareness of infection control pro ... | 2007 | 23277843 |
| hepatitis a vaccine response in hiv-infected patients: are twinrix and havrix interchangeable? | hepatitis a virus (hav) infection remains a health risk for human immunodeficiency virus (hiv)-infected persons. seroconversion rates among hav vaccinated hiv-infected patients have been shown to be reduced compared to the general population. current guidelines regard hav vaccines as interchangeable, however there no published data comparing their efficacy in hiv patients. our study evaluated the impact of different factors, including type of vaccination, on the immunologic response to hepatitis ... | 2012 | 23277097 |
| multiple factors contribute to positive results for hepatitis a virus immunoglobulin m antibody. | in the united states, a successful vaccination program for hepatitis a virus (hav) infection has decreased both its incidence and the true positive rate for diagnostic immunoglobulin m (igm) antibody to hav in acute hepatitis. | 2013 | 23276180 |
| translation directed by hepatitis a virus ires in the absence of active eif4f complex and eif2. | translation directed by several picornavirus ires elements can usually take place after cleavage of eif4g by picornavirus proteases 2a(pro) or l(pro). the hepatitis a virus (hav) ires is thought to be an exception to this rule because it requires intact eif4f complex for translation. in line with previous results we report that poliovirus (pv) 2a(pro) strongly blocks protein synthesis directed by hav ires. however, in contrast to previous findings we now demonstrate that eif4g cleavage by foot-a ... | 2012 | 23272212 |
| havcr-1 expression in human colorectal cancer and its effects on colorectal cancer cells in vitro. | hepatitis a virus cellular receptor 1 (havcr-1) may function as part of the regulatory apparatus for tight junction in human endothelial cells, and is overexpressed in renal cell and ovarian clear cell carcinomas. | 2013 | 23267147 |
| isolation and characterization of a low pathogenic duck hepatitis a virus 3 from south korea. | the d11-jw-018 strain of duck hepatitis a virus (dhav) was isolated from 7-day-old ducklings in kyeonggi province, south korea with no clinical signs of typical hepatitis. phylogenetic analyzed of whole genome showed that d11-jw-018 strain was belonged to dhav-3 genotype. the pathogenicity of the d11-jw-018 strain in 1-, 7-, 14-, and 21-day-old ducklings was examined. mortality of d11-jw-018 strain was lower than drl-62 (dhav-1) age-dependent but incubation period was longer in 1-day-old ducklin ... | 2012 | 23265242 |
| hepatitis e virus and hepatitis a virus exposures in an apparently healthy high-risk population in italy. | the prevalence of anti-hepatitis e virus (hev) and anti-hepatitis a virus (hav), as well as the possible links with socio-demographic and other viral risks factors, were evaluated in an inmates population. | 2012 | 23264095 |
| comparative effectiveness of two doses versus three doses of hepatitis a vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men. | the purpose of this prospective cohort study was to compare the serologic response between human immunodeficiency virus (hiv)-infected men who have sex with men (msm) receiving two and three doses of hepatitis a virus (hav) vaccine and hiv-uninfected msm receiving two doses of hav vaccine. between june 2009 and december 2010, 582 msm aged 18 to 40 years who were seronegative for hav were enrolled in the study. hiv-infected msm received either two doses of hav vaccine (1,440 enzyme-linked immunos ... | 2013 | 23258666 |