Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| an outbreak of influenza b in an isolated nomadic community in jammu & kashmir, india. | community outbreaks of disease amongst nomadic populations generally remain undocumented. following a reported increase in acute respiratory tract infections (ari) in may 2011 in a nomadic population of sangerwini in jammu & kashmir, india, we examined the patients with ari symptoms and their nasal swabs were tested for influenza virus. | 2013 | 24521649 |
| clinical differences between influenza a (h1n1) pdm09 & influenza b infections identified through active community surveillance in north india. | most studies on the clinical presentation with influenza viruses have been conducted in outpatient or inpatient medical facilities with only a few studies in community settings. clinical differences between influenza a (h1n1) pdm 09 and influenza b virus infections have importance for community-based public health surveillance. an active community surveillance at the time of emergence of pandemic influenza provided us with an opportunity to compare the clinical features among patients infected w ... | 2013 | 24521643 |
| occurrence of a case of influenza a(h1n1)pdm09 and b co-infection during the epidemic season 2012-2013. | we report the detection of one case of co-infection with influenza a(h1n1)pdm09 and b, occurred during the 2012-2013 influenza season in sicily. the dual infection was identified in a 18-year-old boy, who was not covered by specific vaccination and who had no other pre-existing risk factors. he presented classical symptoms of influenza-like illness developing no respiratory complications. a(h1n1)pdm09 viral concentration was initially about 10-fold higher than b virus, whereas its clearance was ... | 2014 | 24518691 |
| morphology of influenza b/lee/40 determined by cryo-electron microscopy. | cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza b/lee/40. algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of this pleomorphic virus and distinguish viral surface spikes. the purpose of this research is to examine the architecture of influenza type b virions by cryo-electron tomography and projection image analysis. the aims are to explore the degree of ... | 2014 | 24516628 |
| the roles of hemagglutinin phe-95 in receptor binding and pathogenicity of influenza b virus. | diverged ~4000 years ago, influenza b virus has several important differences from influenza a virus, including lower receptor-binding affinity and highly restricted host range. based on our prior structural studies, we hypothesized that a single-residue difference in the receptor-binding site of hemagglutinin (ha), phe-95 in influenza b virus versus tyr-98 in influenza a/h1-h15, is possibly a key determinant for the low receptor-binding affinity. here we demonstrate that the mutation phe95→tyr ... | 2014 | 24503069 |
| universal influenza b virus genomic amplification facilitates sequencing, diagnostics, and reverse genetics. | although human influenza b virus (ibv) is a significant human pathogen, its great genetic diversity has limited our ability to universally amplify the entire genome for subsequent sequencing or vaccine production. the generation of sequence data via next-generation approaches and the rapid cloning of viral genes are critical for basic research, diagnostics, antiviral drugs, and vaccines to combat ibv. to overcome the difficulty of amplifying the diverse and ever-changing ibv genome, we developed ... | 2014 | 24501036 |
| respiratory viral infections among hospitalized adults: experience of a single tertiary healthcare hospital. | following the 2009 h1n1 pandemic, there have been a large number of studies focusing on the epidemiology and outcomes of influenza a infection; however, there have been fewer studies focused on other respiratory viral infections. | 2014 | 24490751 |
| effectiveness of the 2010 and 2011 southern hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza-associated acute respiratory infection among thai adults aged ≥ 50 years. | inactivated influenza vaccine (iiv) effectiveness has been evaluated among older adults in high-income countries, but data on iiv effectiveness in low- and middle-income countries remain sparse. we conducted a test-negative case-control analysis to estimate 2010 and 2011 trivalent iiv effectiveness against hospitalization with influenza-associated acute respiratory infection (ari) among persons aged ≥ 50 years in rural thailand. | 2014 | 24490684 |
| immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged ≥18 years: a phase iii, randomized trial. | two influenza b lineages have been co-circulating since the 1980s, and because inactivated trivalent influenza vaccine (tiv) contains only one b strain, it provides little/no protection against the alternate b-lineage. we assessed a candidate inactivated quadrivalent influenza vaccine (qiv) containing both b lineages versus tiv in healthy adults. | 2014 | 24486352 |
| clinical and virologic factors associated with reduced sensitivity of rapid influenza diagnostic tests in hospitalized elderly patients and young children. | rapid influenza diagnostic tests (ridts) are commonly used by clinicians to guide patient management. data on sensitivities among hospitalized patients are limited. here, we evaluated the clinical and virologic factors affecting the sensitivities of 2 commercially available ridts (binaxnow influenza a&b and quickvue influenza a+b) on nasopharyngeal aspirate (npa) specimens collected from elderly patients and young children hospitalized for influenza. influenza cases and age-matched negative cont ... | 2014 | 24478479 |
| rash associated with influenza b virus infection. | 2014 | 24476181 | |
| co-infection of influenza b and streptococcus. | 2014 | 24473695 | |
| [preliminary establishment of an electrochemiluminescence immunoassay method for detection of influenza virus b]. | to establish an electrochemiluminescence immunoassay (eclia) for the detection of influenza virus b (flu b), we biotinylated the flu b monoclonal antibody (mab),labeled the paired ab with ruthenium and used the streptavidin-coated microparticles in this study. the ecl intensity was linear with the concentrations of antigen of flu b in the range of 0.55 microg/ml to 17.5 microg/ml, with a detection limit of 0.55 microg/ml (s/n= 3). the precision,sensitivity and specificity were evaluated. the est ... | 2013 | 24459953 |
| influenza a/subtype and b/lineage effectiveness estimates for the 2011-2012 trivalent vaccine: cross-season and cross-lineage protection with unchanged vaccine. | we estimate vaccine effectiveness (ve) against both influenza a/subtypes and b/lineages in canada for the 2011-2012 trivalent inactivated influenza vaccine (tiv) with components entirely unchanged from the 2010-2011 tiv and in the context of phenotypic and genotypic characterization of circulating viruses. | 2014 | 24446529 |
| safety and immunogenicity of an inactivated quadrivalent influenza vaccine in children 6 months through 8 years of age. | strains of 2 distinct influenza b lineages (victoria and yamagata) have cocirculated in the united states for over a decade, but trivalent influenza vaccines (tivs) contain only 1 b-lineage strain. each season, some or most influenza b disease is caused by the b lineage not represented in that season's tiv. quadrivalent influenza vaccines (qivs) containing a strain from each b lineage should resolve this problem. | 2014 | 24445833 |
| sequential influenza b viral load and susceptibility in children treated with oseltamivir and zanamivir. | the objective of this study was to estimate the efficacy of the neuraminidase (na) inhibitors (nais) oseltamivir and zanamivir for decreasing viral load and to investigate whether nai treatment decreases viral susceptibility to nais over time in children with influenza b virus infection. | 2014 | 24445826 |
| economic burden of seasonal influenza b in france during winter 2010-2011. | in france, 2-15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. nevertheless, despite its importance for policy makers, few published studies have evaluated the impact of influenza b. therefore, we assessed the costs associated with influenza b during 2010-2011 in france. | 2014 | 24443900 |
| evidence for a crucial role of a host non-coding rna in influenza a virus replication. | a growing body of evidence suggests the non-protein coding human genome is of vital importance for human cell function. besides small rnas, the diverse class of long non-coding rnas (lncrnas) recently came into focus. however, their relevance for infection, a major evolutionary driving force, remains elusive. using two commercially available microarray systems, namely ncode™ and sureprint™ g3, we identified differential expression of 42 ncrnas during influenza a virus (iav) infection in human lu ... | 2013 | 24440876 |
| structural insights into the membrane fusion mechanism mediated by influenza virus hemagglutinin. | membrane fusion is involved in many fundamental cellular processes and entry of enveloped viruses into host cells. influenza type a virus ha has long served as a paradigm for mechanistic studies of protein-mediated membrane fusion via large-scale structural rearrangements induced by acidic ph. here we report the newly determined crystal structure of influenza b virus ha2 in the postfusion state. together with a large number of previously determined prefusion structures of influenza a and b virus ... | 2014 | 24433110 |
| repetitive fulminant influenza myocarditis requiring the use of circulatory assist devices. | a 52-year-old man was admitted to our hospital due to shortness of breath that developed one week after the diagnosis of influenza infection. he had a past history of myocarditis associated with influenza b infection 16 years before the current admission. the patient's left ventricular function showed diffuse hypokinesis with a left ventricular ejection fraction of 28%. due to the progression of heart failure, the infusion of catecholamines and insertion of an intra-aortic balloon pump were requ ... | 2014 | 24429449 |
| emergency department surveillance as a proxy for the prediction of circulating respiratory viral disease in eastern ontario. | seasonal outbreaks of winter respiratory viruses are responsible for increases in morbidity and mortality in the community. previous studies have used hospitalizations, intensive care unit and emergency department (ed) visits as indicators of seasonal influenza incidence. | 2013 | 24421826 |
| influenza-b associated rhabdomyolysis with acute renal failure. | 2013 | 24413511 | |
| identification of conserved rna secondary structures at influenza b and c splice sites reveals similarities and differences between influenza a, b, and c. | influenza b and c are single-stranded rna viruses that cause yearly epidemics and infections. knowledge of rna secondary structure generated by influenza b and c will be helpful in further understanding the role of rna structure in the progression of influenza infection. | 2014 | 24405943 |
| viral aetiology of acute lower respiratory tract illness in hospitalised paediatric patients of a tertiary hospital: one year prospective study. | acute lower respiratory tract infections (alri), ranked as the second leading cause of death are the primary cause of hospitalisation in children. viruses are the most important causative agents of alri. | 2014 | 24399381 |
| immunogenicity of a 2009 pandemic influenza virus a h1n1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy. | no examination of simultaneous vaccination against pandemic h1n1 and the seasonal influenza virus strains, in children with cancer receiving chemotherapy, are yet published. we investigated the immunogenicity of a whole-virion, inactivated, adjuvanted pandemic h1n1, and seasonal influenza vaccines administered simultaneously to children with cancer undergoing chemotherapy. | 2014 | 24395342 |
| estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the philippines. | although the public health significance of influenza in regions with a temperate climate has been widely recognized, information on influenza burden in tropical countries, including the philippines, remains limited. we aimed to estimate influenza incidence rates for both outpatients and inpatients then characterized their demographic features. | 2014 | 24393336 |
| seasonal influenza vaccine effectiveness against influenza in 2012-2013: a hospital-based case-control study in lithuania. | due to scarce information on seasonal influenza vaccine effectiveness (sive) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. | 2014 | 24370711 |
| influenza associated mortality in southern china, 2010-2012. | influenza caused substantial morbidity and mortality worldwide. the mortality burden caused by influenza has been under evaluation; however, data assessing this burden have been relatively sparse in tropical or subtropical regions. we estimated influenza-associated mortality in guangzhou, china and assessed the excess mortality due to different influenza virus subtypes. | 2014 | 24370709 |
| comparison of in vitro antiviral activity of tea polyphenols against influenza a and b viruses and structure-activity relationship analysis. | influenza poses a particular risk of severe outcomes in the elderly, the very young and those with underlying diseases. tea polyphenols are the natural phenolic compounds in teas, and principally consist of catechins, proanthocyanidins, flavonols, and theaflavins, which antiviral activities have been reported recently. this study is to gain a further insight into potential of various tea polyphenols for inhibiting influenza virus infection. five tea polyphenols exhibited inhibitory activity agai ... | 2014 | 24370660 |
| neurological manifestations of influenza infection in children and adults: results of a national british surveillance study. | the emergence of influenza a(h1n1) 2009 was met with increased reports of associated neurological manifestations. we aimed to describe neurological manifestations of influenza in adults and children in the united kingdom that presented at this time. | 2014 | 24352349 |
| mortality attributable to influenza in england and wales prior to, during and after the 2009 pandemic. | very different influenza seasons have been observed from 2008/09-2011/12 in england and wales, with the reported burden varying overall and by age group. the objective of this study was to estimate the impact of influenza on all-cause and cause-specific mortality during this period. age-specific generalised linear regression models fitted with an identity link were developed, modelling weekly influenza activity through multiplying clinical influenza-like illness consultation rates with proportio ... | 2013 | 24348993 |
| characterization of regional influenza seasonality patterns in china and implications for vaccination strategies: spatio-temporal modeling of surveillance data. | the complexity of influenza seasonal patterns in the inter-tropical zone impedes the establishment of effective routine immunization programs. china is a climatologically and economically diverse country, which has yet to establish a national influenza vaccination program. here we characterize the diversity of influenza seasonality in china and make recommendations to guide future vaccination programs. | 2013 | 24348203 |
| protective efficacy in mice of monovalent and trivalent live attenuated influenza vaccines in the background of cold-adapted a/x-31 and b/lee/40 donor strains. | influenza virus continues to take a heavy toll on human health and vaccination remains the mainstay of efforts to reduce the clinical impact imposed by viral infections. proven successful for establishing live attenuated vaccine donor strains, cold-adapted live attenuated influenza vaccines (caivs) have become an attractive modality for controlling the virus infection. previously, we developed the cold-adapted strains a/x-31 and b/lee/40 as novel donor strains of caivs against influenza a and b ... | 2014 | 24342248 |
| vaccine for prevention of mild and moderate-to-severe influenza in children. | commonly used trivalent vaccines contain one influenza b virus lineage and may be ineffective against viruses of the other b lineage. we evaluated the efficacy of a candidate inactivated quadrivalent influenza vaccine (qiv) containing both b lineages. | 2013 | 24328444 |
| severe pathogenesis of influenza b virus in pregnant mice. | the study on pathogenesis of influenza b virus during pregnancy is limited. here, we showed using a mouse model that influenza b virus could cause severe disease including death during pregnancy. infected pregnant mice resulted in 40% mortality, but infected age-matched non-pregnant mice did not show any death. infected pregnant mice contained high viral loads in lungs with the elevated inductions of inflammatory cytokines and chemokines than infected non-pregnant mice. infected pregnant mice de ... | 2014 | 24314638 |
| seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder. | immune sensitivity to wheat glutens and bovine milk caseins may affect a subset of individuals with bipolar disorder. digested byproducts of these foods are exorphins that have the potential to impact brain physiology through action at opioid receptors. inflammation in the gastrointestinal (gi) tract might accelerate exposure of food antigens to systemic circulation and help explain elevated gluten and casein antibody levels in individuals with bipolar disorder. | 2014 | 24313887 |
| uncommon cause of severe pneumonia: co-infection of influenza b and streptococcus. | influenza and pneumococcus co-infection can cause severe morbidity and mortality. usually, this entails influenza a, while infection by influenza b is rarely serious. the literature describes influenza a epidemics leading to prolific loss of lives, notably the 1918 epidemic was blamed for the deaths of 40 to 50 million people. in this report, four patients were infected by influenza b during the influenza epidemic of 2011/12 in hong kong. all of them were previously healthy and had no chronic di ... | 2013 | 24310663 |
| nucleoprotein of influenza b virus binds to its type a counterpart and disrupts influenza a viral polymerase complex formation. | upon co-infection with influenza b virus (flub), influenza a virus (flua) replication is substantially impaired. previously, we have shown that the nucleoprotein of flub (bnp) can inhibit flua polymerase machinery, retarding the growth of flua. however, the molecular mechanism underlying this inhibitory action awaited further investigation. here, we provide evidence that bnp hinders the proper formation of flua polymerase complex by competitively binding to the nucleoprotein of flua. to exert th ... | 2014 | 24309113 |
| the use of antiviral drugs for influenza: guidance for practitioners 2012/2013. | the present article addresses the use of antiviral drugs in the management of seasonal influenza illness for the 2012/2013 season. it updates the previous document published in 2011 (1). noteworthy guidance updates since 2011 include the following: seasonal influenza in 2012/2013 is predicted to be caused by two human influenza a and one influenza b strain, all of which are anticipated to remain generally susceptible to oseltamivir.the predicted strains are a/california/7/2009 (h1n1) pdm09-like, ... | 2012 | 24294283 |
| influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness. | influenza vaccine is moderately effective for preventing influenza illness. it is not known if vaccination reduces the risk of subsequent hospital admission among patients with vaccine failure and laboratory confirmed influenza illness. | 2014 | 24291201 |
| whole-genome analysis of influenza b viruses of multiple genotypes cocirculating in india. | systematic influenza virus surveillance has been carried out in india since 2004 and has revealed the cocirculation of type b lineages. the genetic diversity of influenza b viruses was observed when full-genome analysis was performed. in 2010, the cocirculation of multiple genotypes was observed. | 2013 | 24285663 |
| [influenza]. | yearly epidemics and occasional pandemics with influenza have been observed for several hundred years. during the last pandemic the reported deaths due to confirmed influenza was lower than expected. new epidemiologic analyses demonstrate that the severity has probably been underestimated. in addition, cohort data from severely ill patients support the use of neuraminidase inhibitors in complicated influenza infections. due to the increasing divergence of the two circulation influenza b strains, ... | 2013 | 24281959 |
| neutralization positive but apparent false-positive hepatitis b surface antigen in a blood donor following influenza vaccination. | we report a case of transient, confirmed positive hepatitis b surface antigen (hbsag) in a 25 year old long term canadian blood services (cbs) donor, who reported receiving 2011-2012 seasonal trivalent (a/h1n1, a/h3n2, influenza b) inactivated influenza vaccine two days before donation. to our knowledge, this report is the first published case implicating influenza vaccine as a possible factor in false-positive hbsag test results. seasonal incidence of repeat-reactive hbsag among cbs donors sugg ... | 2014 | 24268563 |
| household transmission of influenza a and b in a school-based study of non-pharmaceutical interventions. | the effect of school-based non-pharmaceutical interventions (npis) on influenza a and b transmission in children's households has not been estimated in published literature. we use data from a large school-based cluster randomized trial of improved hand and respiratory hygiene measures to explore the secondary transmission of influenza a and b in households of laboratory confirmed influenza cases. data were taken from the pittsburgh influenza prevention project, a cluster-randomized trial of npi ... | 2013 | 24267874 |
| substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. | the molecular basis of antigenic drift was determined for the hemagglutinin (ha) of human influenza a/h3n2 virus. from 1968 to 2003, antigenic change was caused mainly by single amino acid substitutions, which occurred at only seven positions in ha immediately adjacent to the receptor binding site. most of these substitutions were involved in antigenic change more than once. equivalent positions were responsible for the recent antigenic changes of influenza b and a/h1n1 viruses. substitution of ... | 2013 | 24264991 |
| influenza virus surveillance in pakistan during 2008-2011. | there is little information about influenza among the pakistani population. in order to assess the trends of influenza-like-illness (ili) and to monitor the predominant circulating strains of influenza viruses, a country-wide lab-based surveillance system for ili and severe acute respiratory illness (sari) with weekly sampling and reporting was established in 2008. this system was necessary for early detection of emerging novel influenza subtypes and timely response for influenza prevention and ... | 2013 | 24260327 |
| detection of viruses and atypical bacteria associated with acute respiratory infection of children in hubei, china. | acute respiratory infection is the major cause of disease and death in children, particularly in developing countries. however, the spectrum of pathogenic viruses and atypical bacteria that exist in many of these countries remains incompletely characterized. the aim of this study was to examine the spectrum of pathogenic viruses and atypical bacteria associated with acute respiratory infection in children under the age of 16. | 2014 | 24251768 |
| seasonal evaluation of bioaerosols from indoor air of residential apartments within the metropolitan area in south korea. | the aims of the present study were to determine the levels of bioaerosols including airborne culturable bacteria (total suspended bacteria, gram-positive bacteria, staphylococcus, staphylococcus aureus, methicillin-resistant s. aureus (mrsa), and gram-negative bacteria), fungi, endotoxin, and viruses (influenza a, influenza b, respiratory syncytial virus types a/b, parainfluenza virus types 1/2/3, metapnemovirus, and adenovirus) and their seasonal variations in indoor air of residential apartmen ... | 2014 | 24242232 |
| [comparison of clinical features and co-infection between pneumonia caused by influenza virus a and pneumonia caused by influenza virus b among children]. | to compare the clinical features and co-infection between pneumonia caused by influenza virus a (iva) and pneumonia caused by influenza virus b (ivb) among children. | 2013 | 24229596 |
| the substantial hospitalization burden of influenza in central china: surveillance for severe, acute respiratory infection, and influenza viruses, 2010-2012. | published data on influenza in severe acute respiratory infection (sari) patients are limited. we conducted sari surveillance in central china and estimated hospitalization rates of sari attributable to influenza by viral type/subtype. | 2014 | 24209711 |
| generation of anti-influenza aptamers using the systematic evolution of ligands by exponential enrichment for sensing applications. | the systematic evolution of ligands by exponential enrichment (selex) is a selection process for identifying high-affinity selective molecules from a randomized combinatorial nucleic acid library against a wide range of target molecules. using a pool of n25 rna molecules, the selex process was performed against two targets from influenza viruses, namely, intact influenza b/tokio/53/99 and hemagglutinin of infuluenza b jilin/20/2003. the selection processes were evaluated by surface plasmon fluor ... | 2013 | 24200095 |
| survey of causative agents for acute respiratory infections among patients in khartoum-state, sudan, 2010-2011. | this study was carried out to determine causative agents of acute respiratory illness of patients in khartoum state, sudan. | 2013 | 24160894 |
| update: influenza activity--united states and worldwide, may 19-september 28, 2013. | during may 19-september 28, 2013,* the united states experienced low levels of seasonal influenza activity overall. influenza a (h1n1) pdm09 (ph1n1), influenza a (h3n2), and influenza b viruses were detected worldwide and were identified sporadically in the united states. in june, influenza a (h3n2) variant(†) viruses (h3n2)v were first detected in indiana, and between june 18 and september 28, a total of 20 cases of influenza a variant viruses ([h3n2]v and influenza a (h1n1) variant [h1n1]v) we ... | 2013 | 24153315 |
| the 2009 pandemic influenza a(h1n1) coincides with changes in the epidemiology of other viral pathogens causing acute respiratory tract infections in children. | in germany, the outbreak of the novel pandemic 2009 influenza a(h1n1) virus a(h1n1)pdm09 caused a wave of high activity between november 2009 and january 2011. the aim of this study was to investigate the prevalence of 19 respiratory pathogens in children hospitalized for lower respiratory tract infections during the winter influenza seasons of 2009/2010 and 2010/2011 and to observe a possible impact of influenza a(h1n1)pdm09 on the epidemiology of other epidemic viruses. | 2014 | 24150959 |
| hemagglutinin and neuraminidase genes of influenza b viruses circulating in riyadh, saudi arabia during 2010-2011: evolution and sequence analysis. | influenza viruses are known as continuing threats to human public health every year worldwide. evolutionary dynamics of influenza b viruses in humans are in a unique progression having two lineages; b/yam and b/vic-like viruses, which are circulating simultaneously worldwide. there is a considerable lack of data on influenza b viruses circulating in saudi arabia. during the winter-spring season of 2010-2011, 80 nasopharyngeal aspirates were collected from hospitalized patients with flu-like symp ... | 2014 | 24150926 |
| a monoclonal antibody targeting a highly conserved epitope in influenza b neuraminidase provides protection against drug resistant strains. | all influenza viral neuraminidases (na) of both type a and b viruses have only one universally conserved sequence located between amino acids 222-230. a monoclonal antibody against this region has been previously reported to provide broad inhibition against all nine subtypes of influenza a na; yet its inhibitory effect against influenza b viral na remained unknown. here, we report that the monoclonal antibody provides a broad inhibition against various strains of influenza b viruses of both vict ... | 2013 | 24140051 |
| viruses associated with influenza-like-illnesses in papua new guinea, 2010. | influenza-like-illness can be caused by a wide range of respiratory viruses. the etiology of influenza-like-illness in developing countries such as papua new guinea is poorly understood. the etiological agents associated with influenza-like-illness were investigated retrospectively for 300 nasopharyngeal swabs received by the papua new guinea national influenza centre in 2010. real-time pcr/rt-pcr methods were used for the detection of 13 respiratory viruses. patients with influenza-like-illness ... | 2014 | 24136362 |
| [monitoring of viral pathogens in pediatric intensive care unit and analysis of clinical significance]. | to study the characteristics of viral spectrum and clinical features of children in pediatric intensive care unit (picu). | 2013 | 24131585 |
| epidemiology of seasonal influenza in bangkok between 2009 and 2012. | this study investigated influenza activity in bangkok, thailand between june 2009 and july 2012. | 2013 | 24129626 |
| respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms. | the comparative yield of respiratory virus detection from nasopharyngeal aspirate (npa) versus bronchoalveolar lavage (bal) is uncertain. furthermore, the significance of virus detection and its relationship to lower airway neutrophilic inflammation is poorly studied. | 2013 | 24125830 |
| laboratory-confirmed influenza b infection in immunized long-term care facility residents receiving oseltamivir prophylaxis in ontario. | we report on an influenza b outbreak in an ontario long-term care facility in which 2 immunized residents receiving oseltamivir prophylaxis for at least 5 days developed laboratory-confirmed influenza b infection. all isolates were tested for the most common oseltamivir resistance, and none of them had resistance identified. | 2013 | 24113612 |
| influenza b virus-associated pneumonia in pediatric patients: clinical features, laboratory data, and chest x-ray findings. | the clinical significance of influenza b is frequently overlooked, and reports on influenza b pneumonia in children are limited. therefore, the clinical features of associated complications have rarely been reported. the aim of this study is to evaluate the clinical characteristics in pediatric patients with influenza b virus-associated pneumonia. | 2014 | 24113227 |
| viral etiology of influenza-like illnesses during the influenza season between december 2011 and april 2012. | the aim of this study was to determine the frequency of respiratory viruses responsible for respiratory tract infections in turkish children during the 2011-2012 influenza season. nasal swabs were obtained from patients with symptoms suggestive of an influenza-like illness between december 2011 and april 2012. samples were analyzed with multiplex real-time polymerase chain reaction (rt-pcr) to help identify the causative viral pathogen. a total of 200 patients were enrolled in the study. a respi ... | 2014 | 24105787 |
| review of 10 years of clinical experience with chinese domestic trivalent influenza vaccine anflu®. | influenza viruses cause annual winter epidemics globally and influenza vaccination is most effective way to prevent the disease or severe outcomes from the illness, especially in developing countries. however, the majority of the world's total production capacity of influenza vaccine is concentrated in several large multinational manufacturers. a safe and effective preventive vaccine for the developing countries is urgent. anflu®, a chinese domestic preservative-free, split-virus trivalent influ ... | 2014 | 24104060 |
| incidence of symptomatic a(h1n1)pdm09 influenza during the pandemic and post-pandemic periods in a rural indian community. | data on influenza illness rates with population denominators are needed to quantify overall morbidity and to prioritize public health intervention strategies. | 2013 | 24103331 |
| germacrone inhibits early stages of influenza virus infection. | highly pathogenic influenza viruses pose a serious public health threat to humans. although vaccines are available, antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. in this study, germacrone, which is a major component of the essential oils extracted from rhizoma curcuma, was found to inhibit influenza virus replication. germacrone showed antiviral activity against the h1n1 and h3n2 influenza a viruses a ... | 2013 | 24095670 |
| cerebellar mutism and reversible cytotoxic edema in influenza b-associated encephalopathy. | influenza virus-associated neurological complications are rare, though well-documented, especially in children. encephalopathy and seizures are the most common complications and are typically associated with influenza a infection. cerebellar mutism has been rarely reported in association with influenza b infection. | 2013 | 24095574 |
| review of the clinical effectiveness of the neuraminidase inhibitors against influenza b viruses. | influenza a and b viruses cause significant morbidity and mortality worldwide each year. the neuraminidase inhibitors (nais) are the most commonly used class of influenza antiviral drugs for the treatment of infected patients. in vitro studies have shown that influenza b viruses are significantly less susceptible to oseltamivir and other neuraminidase inhibitors compared with influenza a viruses. following analysis of published clinical studies, we show that oseltamivir does appear to have lower ... | 2013 | 24093683 |
| influenza transmission in a cohort of households with children: 2010-2011. | households play a major role in community spread of influenza and are potential targets for mitigation strategies. | 2013 | 24086511 |
| influenza b-induced refractory cardiogenic shock: a case report. | an association between influenza a viruses and myocarditis was noted during the 1918 influenza pandemic. since then, the link between the influenza b virus and fulminant myocarditis or cardiogenic shock has been rarely reported. | 2013 | 24079537 |
| structural basis for the divergent evolution of influenza b virus hemagglutinin. | influenza a and b viruses are responsible for the severe morbidity and mortality worldwide in annual influenza epidemics. currently circulating influenza b virus belongs to the b/victoria or b/yamagata lineage that was diverged from each other about 30-40 years ago. however, a mechanistic understanding of their divergent evolution is still lacking. here we report the crystal structures of influenza b/yamanashi/166/1998 hemagglutinin (ha) belonging to b/yamagata lineage and its complex with the a ... | 2013 | 24074573 |
| virological surveillance of influenza viruses during the 2008-09, 2009-10 and 2010-11 seasons in tunisia. | the data contribute to a better understanding of the circulation of influenza viruses especially in north-africa. | 2013 | 24069267 |
| improved sensitivity of the novel xpert flu test for detection of influenza b virus. | 2013 | 24068015 | |
| characteristics of vaccine failures in a randomized placebo-controlled trial of inactivated influenza vaccine in children. | infections occurring among vaccinated persons (vaccine failures) are known to occur in vaccines with imperfect efficacy. failures among vaccinated children who were infected with vaccine-matched influenza b virus strain have not been adequately characterized. | 2014 | 24061274 |
| heterogeneity of the mdck cell line and its applicability for influenza virus research. | single-cell clones have been established from the mdck cell line, characterized for their morphology and evaluated for their suitability for influenza virus research. three discrete cell morphotypes were identified using light microscopy. besides morphological features, the cell types can be distinguished by the level of expression of surface glycans recognized by peanut agglutinin (pna). all clones were susceptible to infection by influenza viruses of different subtypes of influenza a virus (h1 ... | 2013 | 24058646 |
| comparison of the simplexa flua/b & rsv direct assay and laboratory-developed real-time pcr assays for detection of respiratory virus. | the results of the focus simplexa flua/b & rsv direct assay were compared to those of laboratory-developed reverse transcription pcr tests for 498 nasopharyngeal swabs. concordance rates were 96.6% (476/493; κ = 0.91), 97.6% (481/493; κ = 0.47), and 99.2% (488/492; κ = 0.94) for influenza a, influenza b, and respiratory syncytial virus, respectively. | 2013 | 24048529 |
| prevention and control of seasonal influenza with vaccines. recommendations of the advisory committee on immunization practices--united states, 2013-2014. | this report updates the 2012 recommendations by cdc's advisory committee on immunization practices (acip) regarding the use of influenza vaccines for the prevention and control of seasonal influenza (cdc. prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices [acip]. mmwr 2012;61:613-8). routine annual influenza vaccination is recommended for all persons aged ≥ 6 months. for the 2013-14 influenza season, it is expected that trivalen ... | 2013 | 24048214 |
| a prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and b infections. | it is unclear if higher-dose oseltamivir provides benefit beyond the standard dose in influenza patients who require hospitalization. | 2013 | 24046309 |
| [virus detection in bronchoalveolar lavage fluid of 122 children with severe pneumonia]. | to investigate the prevalence of viral pathogen in children with severe pneumonia in hunan. | 2013 | 24044210 |
| immunologic consequences of chemotherapy for ovarian cancer: impaired responses to the influenza vaccine. | to examine the effect of chemotherapy for ovarian cancer on immunologic function and to define the effect on the serologic response to the influenza vaccine. | 2013 | 24036157 |
| unusually high impact of influenza b during the early 2012-2013 influenza season in wales--epidemiology and clinical analysis of the first 100 cases. | influenza b is often regarded as the milder form of the disease. the early 2012-2013 season in wales saw the highest rate of influenza b-associated primary care consultations since 1994-1995 and considerable hospitalisations. | 2013 | 24034594 |
| differing epidemiological dynamics of influenza b virus lineages in guangzhou, southern china, 2009-2010. | the epidemiological and evolutionary dynamics of the two cocirculating lineages of influenza b virus, victoria and yamagata, are poorly understood, especially in tropical or subtropical areas of southeast asia. we performed a phylogenetic analysis of the hemagglutinin (ha) and neuraminidase (na) sequences of influenza b viruses isolated in guangzhou, a southern chinese city, during 2009 to 2010 and compared the demographic and clinical features of infected patients. we identified multiple viral ... | 2013 | 24027322 |
| the evolving history of influenza viruses and influenza vaccines. | the isolation of influenza virus 80 years ago in 1933 very quickly led to the development of the first generation of live-attenuated vaccines. the first inactivated influenza vaccine was monovalent (influenza a). in 1942, a bivalent vaccine was produced after the discovery of influenza b. it was later discovered that influenza viruses mutated leading to antigenic changes. since 1973, the who has issued annual recommendations for the composition of the influenza vaccine based on results from surv ... | 2013 | 24024871 |
| inactivated quadrivalent split-virus seasonal influenza vaccine (fluarix® quadrivalent): a review of its use in the prevention of disease caused by influenza a and b. | the inactivated quadrivalent split-virus seasonal influenza vaccine [fluarix® quadrivalent, manufactured in dresden (d-qiv)] contains 15 μg haemagglutinin from each of the four influenza virus strains expected to circulate in the upcoming influenza season. unlike seasonal trivalent influenza vaccines (tivs), which have been used previously, quadrivalent influenza vaccines (qivs) contain two influenza a subtype viruses and two b type viruses. as two different b viruses have co-circulated in recen ... | 2013 | 24022123 |
| molecular characterization of the receptor binding structure-activity relationships of influenza b virus hemagglutinin. | selectivity of α2,6-linked human-like receptors by b hemagglutinin (ha) is yet to be fully understood. this study integrates binding data with structure-recognition models to examine the impact of regional-specific sequence variations within the receptor-binding pocket on selectivity and structure activity relationships (sar). the receptor-binding selectivity of influenza b has corresponding to either b/victoria/2/1987 or the b/yamagata/16/88 lineages was examined using surface plasmon resonance ... | 2013 | 24020757 |
| neuraminidase inhibitors for influenza b virus infection: efficacy and resistance. | many aspects of the biology and epidemiology of influenza b viruses are far less studied than for influenza a viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (na) inhibitors (nais). acute respiratory infections are one of the leading causes of death in children and adults, and influenza is among the few respiratory infections that can be prevented and treated by vaccination and antiviral treatment. recent data has sugges ... | 2013 | 24013000 |
| [etiology of fatal pneumonia caused by influenza a(h1n1)pdm2009 virus during the pandemic in russia]. | the results of the study of the autopsy materials from 61 patients with the diagnosis of pneumonia received by virological and genetic methods are reviewed. the materials were studied at the influenza etiology and epidemiology center of the ivanovsky institute of virology, ministry of health and social development of the russian federation, during epidemic seasons 2009-2010 and 2010-2011. the data were analyzed with respect to age, sex, comorbidity diseases and identified on the groups of the ri ... | 2016 | 24006627 |
| the specificity of the influenza b virus hemagglutinin receptor binding pocket: what does it bind to? | the influenza surface glycoprotein hemagglutinin (ha) binds to sialylglycoproteins and sialylglycolipids on the surface of host cells. these sialyl-glycans, usually linked to galactose in either α2,6 or α2,3 configurations, are the receptors for the viral ha, the binding to which promotes viral attachment, membrane fusion, and internalization of the virus. this review examines all of the available receptor binding data on the influenza b ha and provides a structure recognition perspective for th ... | 2013 | 23996486 |
| clinical evaluation of highly sensitive silver amplification immunochromatography systems for rapid diagnosis of influenza. | in this study, the clinical usefulness of silver amplification immunochromatography (sai) influenza virus detection kits, which employed a photographic development technology to increase the sensitivity of the conventional immunochromatographic assay was evaluated. influenza a and b virus strains of nasopharyngeal aspirates obtained from influenza patients were tested at different dilutions on the sai system and conventional immunochromatographic assay kit (espline influenza a & b-n), and detect ... | 2013 | 23994146 |
| sequence-specific cleavage of bm2 gene transcript of influenza b virus by 10-23 catalytic motif containing dna enzymes significantly inhibits viral rna translation and replication. | one of the hallmarks of progression of influenza virus replication is the step involving the virus uncoating that occurs in the host cytoplasm. the bm2 ion channel protein of influenza b virus is highly conserved and is essentially required during the uncoating processes of virus, thus an attractive target for designing antiviral drugs. we screened several dna enzymes (dzs) containing the 10-23 catalytic motif against the influenza b virus bm2 rna. dzs directed against the predicted single-stran ... | 2013 | 23971908 |
| stability of oseltamivir phosphate in syrspend sf, cherry syrup, and syrspend sf (for reconstitution). | oseltamivir (tamiflu) is widely prescribed to treat and prevent influenza virus a, influenza virus b, and h1n1 flu. it is manufactured by roche in 75-mg capsules. the need for other administration options for patients who cannot take capsules and cannot use suspending agents which contain alcohol, sorbitol, or preservatives has led to the compounding of oseltamivir into three suspending vehicles that do not contain these chemicals. all three contain neither alcohol nor sorbitol; the third also h ... | 2013 | 23965375 |
| the frequency and seasonality of influenza and other respiratory viruses in tennessee: two influenza seasons of surveillance data, 2010-2012. | in 2010, the tennessee department of health, in collaboration with the centers for disease control and prevention (cdc), expanded influenza surveillance in tennessee to include other respiratory viruses. | 2013 | 23962104 |
| a report on the association of influenza b virus with respiratory tract infection of hospitalized children in saudi arabia. | influenza viruses are recognized as one of the major causes of respiratory tract infection in young children and elderly people throughout the world. in this report, influenza b virus was detected when 200 clinical samples of nasopharyngeal aspirates, collected from hospitalized children aged from one month to three years with respiratory tract infections, were tested by reverse transcription polymerase chain reaction (rt-pcr). pcr products on the conserved regions sequence of the non-structural ... | 2009 | 23961050 |
| evaluation of the simplexa flu a/b and rsv test for the rapid detection of influenza viruses. | recently, various molecular systems have been introduced for the detection of influenza viruses. among these, the simplexa flu a/b and respiratory syncytial virus (rsv) test can provide results in approximately 2 hr. nasopharyngeal swabs from 241 patients (influenza a, n = 81; influenza b, n = 80; influenza a and influenza b mixed, n = 1; influenza a and rsv a mixed, n = 2; and influenza and rsv negative, n = 77) were analyzed using the simplexa flu a/b and rsv test, a conventional reverse-trans ... | 2013 | 23959434 |
| influenza b virus has global ordered rna structure in (+) and (-) strands but relatively less stable predicted rna folding free energy than allowed by the encoded protein sequence. | influenza a virus contributes to seasonal epidemics and pandemics and contains global ordered rna structure (gors) in the nucleoprotein (np), non-structural (ns), pb2, and m segments. a related virus, influenza b, is also a major annual public health threat, but unlike influenza a is very selective to human hosts. this study extends the search for gors to influenza b. | 2013 | 23958134 |
| [epidemiological characteristics of influenza virus and respiratory syncytial virus among children in wuhan area from 2008 to 2012]. | to investigate the infection status and epidemiological characteristics of influenza virus and respiratory syncytial virus (rsv) in influenza-like illness (ili) of children ( ≤ 14 years) in wuhan area from 2008 to 2012. | 2013 | 23958123 |
| [analysis of genetic variation of hemagglutinin and three internal genes of influenza b virus isolated in zhejiang province from 1999 to 2012]. | to explore the characteristics of the genetic variation of hemagglutinin( ha) and three internal genes coding for the nucleoprotein ( np) , matrix protein ( m) and nonstructural protein ( ns) of influenza b virus. | 2013 | 23958122 |
| efficacy of a single intravenous administration of laninamivir (an active metabolite of laninamivir octanoate) in an influenza virus infection mouse model. | laninamivir, a potent neuraminidase (na) inhibitor, is an active metabolite of laninamivir octanoate (code name: cs-8958) which is a long acting na inhibitor and is commercially available under the brand name inavir in japan to complete the treatment of influenza by a single inhalation. it is supposed that the long acting character is provided by the long retention of laninamivir in the respiratory tract after intranasal administration of laninamivir octanoate in mice and with stable binding of ... | 2013 | 23954190 |
| socio-economic burden of influenza among children younger than 5 years in the outpatient setting in suzhou, china. | the disease burden of children with laboratory-confirmed influenza in china has not been well described. the aim of this study was to understand the epidemiology and socio-economic burden of influenza in children younger than 5 years in outpatient and emergency department settings. | 2013 | 23950882 |
| influenza-b associated rhabdomyolysis and acute renal failure. | we present a 15 year old boy who developed severe rhabdomyolysis and acute renal failure following influenza b infection. his renal function was restored after appropriate therapy for rhabdomyolysis. although rapidly progressive pneumonia, respiratory failure, and acute respiratory distress syndrome are the most common severe complications of influenza b infection, clinicians should be aware that influenza b may be complicated with rhabdomyolysis and acute renal failure in children. | 2013 | 23942401 |