Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| when pigs fly, ucp1 makes heat. | brown and beige adipose tissue may represent important therapeutic targets for the treatment of diabetes and obesity as these organs dissipate nutrient energy as heat through the thermogenic uncoupling protein 1 (ucp1). while mice are commonly used to mimic the potential effects of brown/beige adipose tissue that may act in human metabolism, new animal models are edging into the market for translational medicine. pigs reflect human metabolism better than mice in multiple parameters such as obesi ... | 2015 | 25973382 |
| comparison of autologous (111)in-leukocytes, (18)f-fdg, (11)c-methionine, (11)c-pk11195 and (68)ga-citrate for diagnostic nuclear imaging in a juvenile porcine haematogenous staphylococcus aureus osteomyelitis model. | the aim of this study was to compare (111)in-labeled leukocyte single-photon emission computed tomography (spect) and (18)f-fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet) to pet with tracers that potentially could improve detection of osteomyelitis. we chose (11)c-methionine, (11)c-pk11195 and (68)ga-citrate and validated their diagnostic utility in a porcine haematogenous osteomyelitis model. four juvenile 14-15 weeks old female pigs were scanned seven days after intra-arteri ... | 2015 | 25973338 |
| early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain. | infections that cause inflammation during the postnatal period are common, yet little is known about their impact on brain development in gyrencephalic species. to address this issue, we investigated brain development in domestic piglets which have brain growth and morphology similar to human infants, after experimentally infecting them with porcine reproductive and respiratory syndrome virus (prrsv) to induce an interstitial pneumonia piglets were inoculated with prrsv on postnatal day (pd) 7 a ... | 2015 | 25967923 |
| a longitudinal survey of african swine fever in uganda reveals high apparent disease incidence rates in domestic pigs, but absence of detectable persistent virus infections in blood and serum. | african swine fever (asf) is a fatal, haemorrhagic disease of domestic pigs, that poses a serious threat to pig farmers and is currently endemic in domestic pigs in most of sub-saharan africa. to obtain insight into the factors related to asf outbreaks at the farm-level, a longitudinal study was performed in one of the major pig producing areas in central uganda. potential risk factors associated with outbreaks of asf were investigated including the possible presence of apparently healthy asf-vi ... | 2015 | 25967670 |
| mitochondrial dna diversity of feral pigs from karukinka natural park, tierra del fuego island, chile. | control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. domestic pigs (sus scrofa domestica) were released and became feral in the southern region of chilean tierra del fuego island in the 1900s. currently, they inhabit part of karukinka natural park, an area of global conservation concern. to gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial dna control region to determine ... | 2015 | 25966196 |
| the influence of antral ulcers on intramural gastric nerve projections supplying the pyloric sphincter in the pig (sus scrofa domestica)-neuronal tracing studies. | gastric ulcerations in the region of antrum pylori represent a serious medical problem in humans and animals. such localization of ulcers can influence the intrinsic descending nerve supply to the pyloric sphincter. the pyloric function is precisely regulated by intrinsic and extrinsic nerves. impaired neural regulation could result in pyloric sphincter dysfunction and gastric emptying malfunction. the aim of the study was to determine the effect of gastric antral ulcerations on the density and ... | 2015 | 25962176 |
| transfection of rna from organ samples of infected animals represents a highly sensitive method for virus detection and recovery of classical swine fever virus. | translation and replication of positive stranded rna viruses are directly initiated in the cellular cytoplasm after uncoating of the viral genome. accordingly, infectious virus can be generated by transfection of rna genomes into susceptible cells. in the present study, efficiency of conventional virus isolation after inoculation of cells with infectious sample material was compared to virus recovery after transfection of total rna derived from organ samples of pigs infected with classical swine ... | 2015 | 25961582 |
| a novel swine model of spontaneous hypertension with sympathetic hyperactivity responds well to renal denervation. | the large animal model of arterial hypertension is very valuable to test the antihypertensive drugs and devices. we characterized a novel swine model of spontaneous hypertension and investigated its response to renal denervation (rdn). | 2016 | 25958303 |
| yersinia enterocolitica isolates from wild boars hunted in lower saxony, germany. | yersiniosis is strongly associated with the consumption of pork contaminated with enteropathogenic yersinia enterocolitica, which is harbored by domestic pigs without showing clinical signs of disease. in contrast to data on y. enterocolitica isolated from conventionally reared swine, investigations into the occurrence of y. enterocolitica in wild boars in germany are rare. the objectives of the study were to get knowledge about these bacteria and their occurrence in wild boars hunted in norther ... | 2015 | 25956779 |
| pirnas from pig testis provide evidence for a conserved role of the piwi pathway in post-transcriptional gene regulation in mammals. | piwi-interacting (pi-) rnas guide germline-expressed piwi proteins in order to suppress the activity of transposable elements (tes). but notably, the majority of pachytene pirnas in mammalian testes is not related to tes. this raises the question of whether the piwi/pirna pathway exerts functions beyond te silencing. although gene-derived pirnas were described many times, a possible gene-regulatory function was doubted due to the absence of antisense pirnas. here we sequenced and analyzed pirnas ... | 2015 | 25950437 |
| malignant catarrhal fever in a vietnamese pot-bellied pig. a potential threat to pigs in mixed-species exhibits? | malignant catarrhal fever (mcf) represents a sporadic and often fatal disease in various ungulate species including rarely swine. a close contact between susceptible and reservoir species of ovine herpesvirus-2 (ovhv-2) is a requirement for virus transmission. as in ruminants, a rapid course of disease with lymphohistiocytic meningoencephalitis and necrotizing vasculitis in multiple organs is frequently seen in porcine mcf. this report describes a case of mcf in a vietnamese pot-bellied pig, whi ... | 2015 | 25947878 |
| a nuclear magnetic resonance spectroscopy as a method for evaluation of in vivo poly-l-lactide biodegradation kinetics from stent-polymer matrices: an experimental study utilizing porcine model of in-stent restenosis. | we aimed to comprehensively evaluate poly-lactide polymer degradation and sirolimus release kinetics from a drug-eluting stent matrix in the in vivo setting using a nuclear magnetic resonance (nmr) method. | 2016 | 25944843 |
| the assessment of african swine fever virus risk to belgium early 2014, using the quick and semiquantitative pandora screening protocol. | a risk assessment was organized during the early eu asf outbreaks of early 2014 (february-april) and performed in cooperation with 15 belgian and european experts on asfv and its epidemiology in pigs/wild boar. african swine fever (asf) is considered as one of the most dangerous infectious pig diseases, causing many outbreaks. since the end of 2013 - early 2014, several outbreaks within the european union (lithuania, poland, estonia and latvia) were reported to oie, which prompted several risk a ... | 2017 | 25939453 |
| estimating the basic reproductive number (r0) for african swine fever virus (asfv) transmission between pig herds in uganda. | african swine fever (asf) is a highly contagious, lethal and economically devastating haemorrhagic disease of domestic pigs. insights into the dynamics and scale of virus transmission can be obtained from estimates of the basic reproduction number (r0). we estimate r0 for asf virus in small holder, free-range pig production system in gulu, uganda. the estimation was based on data collected from outbreaks that affected 43 villages (out of the 289 villages with an overall pig population of 26,570) ... | 2015 | 25938429 |
| expression of vpac1 receptor at the level of mrna and protein in the porcine female reproductive system. | the presence and distribution of vasoactive intestinal polypeptide (vip) receptor vpac1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (rt-pcr and immunoblot) and immunohistochemistry. the expression of vpac1 receptor at mrna level was confirmed with rt-pcr in all the studied parts of the porcine female reproductive system by the presence of 525 bp pcr product and at the level of proteins by the detection of 46 kda pr ... | 2015 | 25928928 |
| a next generation semiconductor based sequencing approach for the identification of meat species in dna mixtures. | the identification of the species of origin of meat and meat products is an important issue to prevent and detect frauds that might have economic, ethical and health implications. in this paper we evaluated the potential of the next generation semiconductor based sequencing technology (ion torrent personal genome machine) for the identification of dna from meat species (pig, horse, cattle, sheep, rabbit, chicken, turkey, pheasant, duck, goose and pigeon) as well as from human and rat in dna mixt ... | 2015 | 25923709 |
| course and transmission characteristics of oral low-dose infection of domestic pigs and european wild boar with a caucasian african swine fever virus isolate. | in 2007, african swine fever virus (asfv) was introduced into the transcaucasian countries and russia. since then, it has spread alarmingly and reached the european union. asfv strains are highly virulent and lead to almost 100% mortality under experimental conditions. however, the possibility of dose-dependent disease courses has been discussed. for this reason, a study was undertaken to assess the risk of chronic disease and the establishment of carriers upon low-dose oronasal infection of dom ... | 2015 | 25916610 |
| trichinella pseudospiralis in the iberian peninsula. | nematode worms of the genus trichinella are zoonotic parasites circulating in most continents, including europe. in spain, trichinella spiralis and trichinella britovi are highly prevalent in wildlife but seldom in domestic pigs. in portugal, only t. britovi was documented in wild carnivores. in the period 2006-2013 in spain, 384 (0.0001%) pigs and 1399 (0.20%) wild boars (sus scrofa) were positive for trichinella spp. larvae, which were identified as t. spiralis or t. britovi. in 2014, trichine ... | 2015 | 25913596 |
| fluid dynamics simulation of right ventricular outflow tract oversizing. | repair of the right ventricular outflow tract (rvot) in paediatric cardiac surgery remains challenging due to the high reoperation rate. intimal hyperplasia and consequent arteriosclerosis is one of the most important limitation factors for graft durability. since local shear stress and pressure are predictive elements for intimal hyperplasia and wall degeneration, we sought to determine in an oversized 12-mm rvot model, with computed fluid dynamics simulation, the local haemodynamical factors t ... | 2015 | 25912476 |
| detection and molecular analysis of pseudorabies virus strains isolated from dogs and a wild boar in italy. | aujeszky's disease (ad) is one of the most economically important diseases of farmed pigs. wild boars can act as reservoirs and might represent a potential threat for domestic animals, including dogs. the aim of this study was to report the results of an ad survey based on the pseudorabies virus (prv) genome detection in samples of dogs clinically suspected of ad and of wild boars collected during four consecutive hunting seasons in the period 2010-2014. genomic characterization was based on the ... | 2015 | 25912160 |
| real-time in-vivo imaging of pulmonary capillary perfusion using probe-based confocal laser scanning endomicroscopy in pigs: an interventional laboratory study. | little is known about real-time in-vivo microscopy of pulmonary capillary perfusion because current microscopy requires direct access to lung tissue with surgical intervention such as the thoracic-window technique and open-lung model. | 2015 | 25906262 |
| autophagy portends the level of cardiac hypertrophy in experimental hypertensive swine model. | left ventricular (lv) hypertrophy (lvh) plays an important role in hypertensive heart disease, and may be accompanied by myocardial autophagy. however, the pattern of autophagy during evolution of lvh is unclear. we hypothesized that autophagy activation indicates advancing cardiac lvh with tissue remodeling. | 2016 | 25904651 |
| tvp1022: a novel cardioprotective drug attenuates left ventricular remodeling after ischemia/reperfusion in pigs. | the current cornerstone treatment of myocardial infarction (mi) is restoration of coronary blood flow by means of thrombolytic therapy or primary percutaneous coronary intervention. however, reperfusion of ischemic myocardium can actually provoke tissue damage, defined as "ischemia-reperfusion (i/r) injury." tvp1022 [the s-isomer of rasagiline (azilect), fda-approved anti-parkinson's drug] was found to exert cardioprotective activities against various cardiac insults, such as chronic heart failu ... | 2015 | 25900266 |
| pluripotent and metabolic features of two types of porcine ipscs derived from defined mouse and human es cell culture conditions. | the domestic pig is an excellent animal model for stem cell research and clinical medicine. there is still no suitable culture condition to generate authentic porcine embryonic stem cells (pescs) and high quality porcine induced pluripotent stem cells (pipscs). in this study, we found that culture conditions affected pluripotent and metabolic features of pipscs. using defined human embryonic stem cell (hesc) and mouse esc (mesc) culture conditions, we generated two types of pipscs, one of which ... | 2015 | 25893435 |
| serological prevalence of viral agents that induce reproductive failure in south korean wild boar. | viral agents associated with reproductive failure such as aujeszky's disease virus (adv), encephalomyocarditis virus (emcv), and porcine parvovirus (ppv) have also been identified in european wild boar. to screen for the presence of antibodies against adv, emcv, and ppv from wild boar (sus scrofa) in south korea, 481 serum samples were collected from wild boar hunted between december 2010 and may 2011. | 2015 | 25888836 |
| genome-wide association analyses reveal significant loci and strong candidate genes for growth and fatness traits in two pig populations. | recently, genome-wide association studies (gwas) have been reported on various pig traits. we performed a gwas to analyze 22 traits related to growth and fatness on two pig populations: a white duroc × erhualian f2 intercross population and a chinese sutai half-sib population. | 2015 | 25885760 |
| exploring the genetic signature of body size in yucatan miniature pig. | since being domesticated about 10,000-12,000 years ago, domestic pigs (sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. however, yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. this renders the yucatan miniature pig a valuable model for understanding the evolution of body size. we investigate the genetic signature for selection of body size in the yucatan min ... | 2015 | 25885114 |
| prevalence of infection with toxoplasma gondii in landrace and mixed breed pigs slaughtered in baja california sur state, mexico. | we performed a cross-sectional study to determine the seroprevalence of toxoplasma gondii infection in 308 domestic pigs slaughtered in la paz, baja california sur state, mexico using the modified agglutination test (mat, cut off 1:25). forty (13%) of the 308 pigs were seropositive with mat titers of 1:25 in 16, 1:50 in 5, 1:100 in 4, 1:200 in 5, 1:400 in 3, 1:800 in 3, 1:1600 in 2, and 1:3200 in 2. multivariate analysis of pigs' characteristics showed that seropositivity to t. gondii was negati ... | 2015 | 25883799 |
| spatial characterization of colonies of the flying fox bat, a carrier of nipah virus in thailand. | a major reservoir of nipah virus is believed to be the flying fox genus pteropus, a fruit bat distributed across many of the world's tropical and sub-tropical areas. the emergence of the virus and its zoonotic transmission to livestock and humans have been linked to losses in the bat's habitat. nipah has been identified in a number of indigenous flying fox populations in thailand. while no evidence of infection in domestic pigs or people has been found to date, pig farming is an active agricultu ... | 2015 | 25880385 |
| development of a new lamp assay for the detection of csfv strains from cuba: a proof-of-concept study. | classical swine fever (csf) is a devastating animal disease of great economic impact worldwide. in many countries, csf has been endemic for decades, and vaccination of domestic pigs is one of the measures to control the disease. consequently, differentiating infected from vaccinated animals by antibody elisa screening is not applicable. in some countries, such as cuba, lack of molecular techniques for sensitive, rapid and reliable detection of virus genomes is a critical point. to overcome this ... | 2015 | 25877822 |
| the first detection of prrsv in wild boars in slovakia. | prrsv was confirmed by a nested rt-pcr in two out of 129 samples originating from wild boars from eastern slovakia. virus isolates were genetically typed in orf7 as prrsv-1, eu-1 with 99.7% (sample 14wb) and 100% (sample 10wb) nucleotide sequence similarity to lelystad reference strain and porcilis prrs vaccine strain, respectively. the origin of prrsv in these wild boars is unclear but it is highly likely that virus was transmitted from vaccinated domestic pigs to wild boars. | 2015 | 25876282 |
| effect of body mass and clothing on carrion entomofauna. | carcass mass largely affects pattern and rate of carrion decomposition. supposedly, it is similarly important for carrion entomofauna; however, most of its likely effects have not been tested experimentally. here, simultaneous effects of carcass mass and clothing are analyzed. a factorial block experiment with four levels of carcass mass (small carcasses 5-15 kg, medium carcasses 15.1-30 kg, medium/large carcasses 35-50 kg, large carcasses 55-70 kg) and two levels of carcass clothing (clothed an ... | 2015 | 25874664 |
| analysis of carcass and meat quality traits and nutritional values of hybrid wild boars under different crossing systems. | the aim of this study was to analyze the results of two crossing systems between wild boars and different domesticated pig breeds. hybrid wild boars were produced by crossing captured wild boars with meishan pigs and ly sows according to the traditional production system. the resultant commercial hybrids were black and white in coat color, respectively. significant differences were found in the carcass and meat quality traits and nutritional values between these two hybrid wild boars. compared w ... | 2015 | 25867408 |
| neurophysiological monitoring during acute and progressive experimentally induced compression injury of the spinal cord in pigs. | to evaluate the degree of acute or progressive lateral compression needed to cause neurologic injury to the spinal cord assessed by electrophysiological monitoring. | 2017 | 25862652 |
| corrigendum: cellular scaling rules for the brain of artiodactyla include a highly folded cortex with few neurons. | [this corrects the article on p. 128 in vol. 8, pmid: 25429261.]. | 2015 | 25859187 |
| staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants. | we developed a porcine dermal explant model to determine the extent to which staphylococcus aureus biofilm communities deplete oxygen, change ph, and produce damage in underlying tissue. microelectrode measurements demonstrated that dissolved oxygen (do) in biofilm-free dermal tissue was 4.45 ± 1.17 mg/liter, while do levels for biofilm-infected tissue declined sharply from the surface, with no measurable oxygen detectable in the underlying dermal tissue. magnetic resonance imaging demonstrated ... | 2015 | 25847960 |
| trichinellosis in vietnam. | trichinellosis is a zoonotic parasitic disease with a worldwide distribution. the aim of this work was to describe the epidemiological and clinical data of five outbreaks of trichinellosis, which affected ethnic minorities living in remote mountainous areas of northwestern vietnam from 1970 to 2012. trichinellosis was diagnosed in 126 patients, of which 11 (8.7%) were hospitalized and 8 (6.3%) died. all infected people had consumed raw pork from backyard and roaming pigs or wild boar at wedding, ... | 2015 | 25846295 |
| the effects of altered maxillary growth on patterns of mandibular rotation in a pig model. | a thorough understanding of influence of maxillary growth on patterns of mandibular rotation during development is important with regard to the treatment of skeletal discrepancies. in the present study, we examined whether experimentally altered maxillary position has a significant influence on patterns of mandibular rotation in a pig model. | 2015 | 25841069 |
| the chimerical genome of isla del coco feral pigs (costa rica), an isolated population since 1793 but with remarkable levels of diversity. | the history of domestic species and of their wild ancestors is not a simple one, and feral processes can clarify key aspects of this history, including the adaptive processes triggered by new environments. here, we provide a comprehensive genomic study of isla del coco (costa rica) feral pigs, a unique population that was allegedly founded by two individuals and has remained isolated since 1793. using snp arrays and genome sequencing, we show that cocos pigs are hybrids between asian and europea ... | 2015 | 25827466 |
| distribution and molecular characterization of hepatitis e virus in domestic animals and wildlife in croatia. | hepatitis e is becoming a growing health concern in european countries as an increase of sporadic human cases of unknown origin has been recorded lately. its causative agent, hepatitis e virus (hev), is known to have zoonotic potential and thus the role of domestic and wild animals in the chain of viral spread should be considered when investigating risk factors and the epidemiology of the disease. a comprehensive survey based on viral rna detection was carried out in croatia including blood, sp ... | 2015 | 25820413 |
| flexible growing rods: a pilot study to determine if polymer rod constructs may provide stability to skeletally immature spines. | surgical treatments for early onset scoliosis (eos), including growing rod constructs, involve many complications. some are due to biomechanical factors. a construct that is more flexible than current instrumentation systems may reduce complications. the purpose of this preliminary study was to determine spine range of motion (rom) after implantation of simulated growing rod constructs with a range of clinically relevant structural properties. the hypothesis was that rom of spines instrumented w ... | 2015 | 25810752 |
| african swine fever virus georgia isolate harboring deletions of mgf360 and mgf505 genes is attenuated in swine and confers protection against challenge with virulent parental virus. | african swine fever virus (asfv) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences for the swine industry. the control of african swine fever (asf) has been hampered by the unavailability of vaccines. experimental vaccines have been developed using genetically modified live attenuated asfvs where viral genes involved in virus virulence were removed from the genome. multigene family 360 (mgf360) and mgf505 represent a gro ... | 2015 | 25810553 |
| wild boars from sweden, austria, the czech republic and japan possess intact mannose-binding lectin 2 (mbl2) genes. | the two-nucleotide deletion recently detected in the mannose-binding lectin 2 gene in purebred and crossbred domestic pigs was not found among 68 wild boars representing 4 populations from europe and asia. this suggests that the deletion is a result of breeding and/or genetic drift/bottle necks. | 2015 | 25809846 |
| experimental infection of domestic pigs with african swine fever virus lithuania 2014 genotype ii field isolate. | an experimental infection was conducted to evaluate horizontal transmission, clinical, virological and humoral response induced in domestic pigs infected with african swine fever (asf) genotype ii virus circulating in 2014 into the european union (eu). ten naive pigs were placed in contact with eight pigs experimentally inoculated with the lithuanian lt14/1490 asf virus (asfv) responsible for the first asf case detected in wild boar in lithuania in january 2014. clinical examination and rectal t ... | 2017 | 25808027 |
| effects of bovine lactoferrin in surgically created bone defects on bone regeneration around implants. | the aim of this experimental study was to evaluate the effect of bovine lactoferrin (blf)-loaded gelatin microspheres (gm) used in combination with anorganic bovine bone on bone regeneration in surgically created bone defects around tooth implants. twenty-four uniform bone defects were created in the frontal bone via an extraoral approach in 12 domestic pigs. twenty-four implants were placed at the center of the defects. in eight animals one of these defects was filled with 0.3 ml anorganic bovi ... | 2015 | 25807903 |
| functional characterization of a novel lytic phage ecsw isolated from sus scrofa domesticus and its potential for phage therapy. | in this study, multi-drug resistant escherichia coli sw1 (e. coli sw1) and active lytic phage ecsw was isolated from feces samples of sus scrofa domesticus (piglet) suffering from diarrhea. transmission electron microscopy (tem) indicated that isolated ecsw belongs to the myoviridae family with an icosahedral head (80 ± 4) and a long tail (180 ± 5 nm). the ecsw phage genome size was estimated to be approximately 75 kb of double-stranded dna (dsdna). phage dynamic studies show that the latent per ... | 2015 | 25805216 |
| snp marker discovery in koala tlr genes. | toll-like receptors (tlrs) play a crucial role in the early defence against invading pathogens, yet our understanding of tlrs in marsupial immunity is limited. here, we describe the characterisation of nine tlrs from a koala immune tissue transcriptome and one tlr from a draft sequence of the koala genome and the subsequent development of an assay to study genetic diversity in these genes. we surveyed genetic diversity in 20 koalas from new south wales, australia and showed that one gene, tlr10 ... | 2015 | 25799012 |
| humans (homo sapiens) judge the emotional content of piglet (sus scrofa domestica) calls based on simple acoustic parameters, not personality, empathy, nor attitude toward animals. | the vocal expression of emotion is likely driven by shared physiological principles among species. however, which acoustic features promote decoding of emotional state and how the decoding is affected by their listener's psychology remain poorly understood. here we tested how acoustic features of piglet vocalizations interact with psychological profiles of human listeners to affect judgments of emotional content of heterospecific vocalizations. we played back 48 piglet call sequences recorded in ... | 2015 | 25798794 |
| a study of lymphoid organs and serum proinflammatory cytokines in pigs infected with african swine fever virus genotype ii. | african swine fever virus (asfv), the causative agent of one of the most important viral diseases of domestic pigs for which no vaccine is available, causes immune system disorders in infected animals. in this study, the serum levels of proinflammatory cytokines, as well as the histological and cellular constitution of lymphoid organs of pigs infected with asfv genotype ii were investigated. the results showed a high degree of lymphocyte depletion in the lymphoid organs, particularly in the sple ... | 2015 | 25797197 |
| standardization of the experimental autoimmune myasthenia gravis (eamg) model by immunization of rats with torpedo californica acetylcholine receptors--recommendations for methods and experimental designs. | myasthenia gravis (mg) with antibodies against the acetylcholine receptor (achr) is characterized by a chronic, fatigable weakness of voluntary muscles. the production of autoantibodies involves the dysregulation of t cells which provide the environment for the development of autoreactive b cells. the symptoms are caused by destruction of the postsynaptic membrane and degradation of the achr by igg autoantibodies, predominantly of the g1 and g3 subclasses. active immunization of animals with ach ... | 2015 | 25796590 |
| selection and validation of reference genes for qrt-pcr expression analysis of candidate genes involved in olfactory communication in the butterfly bicyclus anynana. | real-time quantitative reverse transcription pcr (qrt-pcr) is a technique widely used to quantify the transcriptional expression level of candidate genes. qrt-pcr requires the selection of one or several suitable reference genes, whose expression profiles remain stable across conditions, to normalize the qrt-pcr expression profiles of candidate genes. although several butterfly species (lepidoptera) have become important models in molecular evolutionary ecology, so far no study aimed at identify ... | 2015 | 25793735 |
| the investigation of interspecies diversity of erythrocyte aggregation properties by two different photometric methods in four animal species. | among the haemorheological parameters, red blood cell (rbc) aggregation shows the largest interspecies diversity, and often controversial data can be found in the literature, besides the methodology-dependent issues. in this present investigation, we compared four experimental/laboratory animal species' rbc aggregation by two different photometric methods for better revealing the differences. blood samples (k3-edta, 1.5 mg/ml) were taken from female animals: 16 inbred mice (mus musculus, cardiac ... | 2015 | 25788141 |
| serological and molecular evidence of hepadnavirus infection in swine. | recently, investigations in a swine herd identified evidence of the existence of a novel member of the hepadnavirus family endemic in swine. the aim of this study was to investigate the serological and molecular markers of hepadnavirus circulation in brazilian domestic swine and wild boar herds, and to evaluate the identity with hbv and other hepadnaviruses reported previously. | 2015 | 25780820 |
| atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. | atrial fibrillation (af) and heart failure (hf) are two of the most common cardiovascular diseases. they often coexist and account for significant morbidity and mortality. alterations in cellular ca2+ homeostasis play a critical role in af initiation and maintenance. this study was designed to specifically elucidate af-associated remodeling of atrial ca2+ cycling in the presence of mild hf. af was induced in domestic pigs by atrial burst pacing. the animals underwent electrophysiologic and echoc ... | 2015 | 25775120 |
| prevalence of hepatitis e virus in populations of wild animals in comparison with animals bred in game enclosures. | hepatitis e virus (hev) is now accepted as a zoonotic virus, and domestic pigs, wild boars and deer are recognised as natural reservoirs of the pathogen. in this study, 762 animals (wild boars, fallow deer, red deer, sika deer, roe deer and mouflons) originating from the wild and from game enclosures were tested for the presence of hev rna by qrt-pcr. hev rna was detected in wild boars (96/450), red deer (2/169), roe deer (1/30) and mouflons (5/39). the sequence relationship between hev isolates ... | 2015 | 25771162 |
| a genome-wide scan for signatures of directional selection in domesticated pigs. | animal domestication involved drastic phenotypic changes driven by strong artificial selection and also resulted in new populations of breeds, established by humans. this study aims to identify genes that show evidence of recent artificial selection during pig domestication. | 2015 | 25765548 |
| enhanced perfusion during advanced life support improves survival with favorable neurologic function in a porcine model of refractory cardiac arrest. | to improve the likelihood for survival with favorable neurologic function after cardiac arrest, we assessed a new advanced life support approach using active compression-decompression cardiopulmonary resuscitation plus an intrathoracic pressure regulator. | 2015 | 25756411 |
| establishing a reproducible hypertrophic scar following thermal injury: a porcine model. | our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. to address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. | 2015 | 25750848 |
| investigating the role of free-ranging wild boar (sus scrofa) in the re-emergence of enzootic pneumonia in domestic pig herds: a pathological, prevalence and risk-factor study. | enzootic pneumonia (ep) caused by mycoplasma hyopneumoniae has a significant economic impact on domestic pig production. a control program carried out from 1999 to 2003 successfully reduced disease occurrence in domestic pigs in switzerland, but recurrent outbreaks suggested a potential role of free-ranging wild boar (sus scrofa) as a source of re-infection. since little is known on the epidemiology of ep in wild boar populations, our aims were: (1) to estimate the prevalence of m. hyopneumoniae ... | 2015 | 25747151 |
| crimped braided sleeves for soft, actuating arm in robotic abdominal surgery. | this paper investigates different types of crimped, braided sleeve used for a soft arm for robotic abdominal surgery, with the sleeve required to contain balloon expansion in the pneumatically actuating arm while it follows the required bending, elongation and diameter reduction of the arm. | 2015 | 25744663 |
| prevalence of emerging porcine parvoviruses and their co-infections with porcine circovirus type 2 in china. | a total of 450 samples from domestic pigs in china were tested for porcine parvoviruses (ppvs) and co-infections with porcine circovirus type 2 (pcv2), and their complete capsid genes were sequenced. the prevalence of ppv1, ppv2, ppv3, ppv4, and pcv2 was 5.56 %, 39.56 %, 45.11 %, 21.56 %, and 47.33 %, respectively, and co-infection with pcv2 occurred in 4 % (ppv1), 22.44 % (ppv2), 24 % (ppv3), and 12 % (ppv4) of the samples. phylogenetic analysis revealed two main lineages for each virus, and re ... | 2015 | 25742931 |
| experimental infection with the toxoplasma gondii me-49 strain in the brazilian br-1 mini pig is a suitable animal model for human toxoplasmosis. | toxoplasma gondii causes toxoplasmosis, a worldwide disease. experimentation with pigs is necessary for the development of new therapeutic approaches to human diseases. br-1 mini pigs were intramuscularly infected with t. gondii with tachyzoites (rh strain) or orally infected with cysts (me-49 strain). haematology and serum biochemistry were analysed and buffy coat cells were inoculated in mice to determine tachyzoite circulation. no alterations were observed in erythrocyte and platelet values; ... | 2015 | 25742268 |
| a novel porcine model for chemically inducible crohn's-like reaction. | new animal models provide insights into the pathogenesis of different types of inflammatory bowel disease as well as novel pathways for new therapeutic options. however, the scarcity of large animal models hinders the research and development of new surgical procedures and technological devices in inflammatory bowel disease surgery. common small animal inducible models involve chemical agents that result in the development of acute intestinal inflammation. | 2015 | 25739171 |
| [assessment of bovine pericardium (tutomesh®) and coated polypropylene (proceed®) in the para-oesophageal position in a pig model]. | hiatal hernias are nowadays increasingly treated with meshes. often, biological implants are being used for this application. oesophageal perforations have been reported as rare but serious complications from the application of synthetic meshes at the oesophageal hiatus. the role of the different mesh types has not been clearly established by experimental research so far. in the present large animal model, we investigated two implant types (tutomesh® and proceed®) with respect to their biocompat ... | 2015 | 25738433 |
| effectiveness of microsatellite and single nucleotide polymorphism markers for parentage analysis in european domestic pigs. | parentage analysis and individual identification are recent, promising methods that have been applied to evolutionary and ecological studies, as well as conservation management. parental exclusion relying on polymorphic microsatellites has been used worldwide in parentage determination, while the low mutation rate and genotyping error rate of single nucleotide polymorphisms (snps) make them another important marker for pedigree tracing. here, we compared the effectiveness of microsatellites and ... | 2015 | 25730075 |
| evidence for a link between tail biting and central monoamine metabolism in pigs (sus scrofa domestica). | tail biting in pigs is a major welfare problem within the swine industry. even though there is plenty of information on housing and management-related risk factors, the biological bases of this behavioral problem are poorly understood. the aim of this study was to investigate a possible link between tail biting, based on behavioral recordings of pigs during an ongoing outbreak, and certain neurotransmitters in different brain regions of these pigs. we used a total of 33 pigs at a farm with a lon ... | 2015 | 25728243 |
| west nile virus serosurveillance in pigs, wild boars, and roe deer in serbia. | west nile virus (wnv) is maintained in nature in an enzootic transmission cycle between birds and mosquitoes, but it also infects many other vertebrates, including humans and horses, in which it can induce severe neurological diseases; however, data about virus circulation in other mammals is scarce. wnv has a history of recent outbreaks in europe, including serbia, where it was identified for the first time in 2010 in mosquitoes and in 2012 in birds and humans, being responsible for over 300 co ... | 2015 | 25724332 |
| the relation between catheter occlusion and backflow during intraparenchymal cerebral infusions. | background/aims: the distribution of infusate into the brain by convection-enhanced delivery can be affected by backflow along the catheter shaft. this work assesses the following: (1) whether tissue coring and occlusion of the catheter lumen occurs when an open end-port catheter is inserted, (2) whether there is a relationship between intracatheter pressure and backflow, and (3) whether catheter occlusion increases backflow. methods: freshly excised monkey brains were used to assess tissue cori ... | 2015 | 25721097 |
| secondary structure analysis of swine pasivirus (family picornaviridae) rna reveals a type-iv ires and a parechovirus-like 3' utr organization. | the potential rna structures of the 5' and 3' untranslated regions (utrs) and cis-acting replication elements (cres) of a novel pasivirus (pav) genotype (family picornaviridae) were analysed. pav-a3 (km259923) was identified in a faecal sample from a domestic pig in hungary with posterior paraplegia of unknown etiology. based on likely structural features of the 5' utr, the pasiviruses were inferred to possess hepacivirus/pestivirus-like type-iv ires. the pasivirus cre was mapped to the 2b genom ... | 2015 | 25716922 |
| reply to 'on genetic differentiation between domestic pigs and tibetan wild boars'. | 2015 | 25711862 | |
| on genetic differentiation between domestic pigs and tibetan wild boars. | 2015 | 25711861 | |
| [classifier of domestic pig (sus scrofa domesticus) automatic chromosome identification]. | automated chromosome classification is an essential task in cytogenetics of animals and plants. until now the automatic karyotyping systems were obtained only for human chromosomes. the main aim of this study was to develop the automatic pig chromosome classifier using image processing software "videotest-karyo 3.1". to solve this problem 1578 chromosomes from 47 metaphases were used. the constructed classifier was checked with the use of additional sample of metaphases classified in fully autom ... | 2014 | 25711088 |
| [genetic components and the uncertainty of the phenotypic realization of the mass of newborns in domestic pigs sus scrofa l]. | in this article, we discuss the features of the genetic determination of a continuous quantitative trait, the mass of newborn offspring in populations of the domestic pig. we defined several components that determine the phenotypic trait, such as the maternal effect, complete dominance, interaction of the parental alleles in the genotype of the offspring, and the uncertainty of phenotypic realization of genotype. we found that a phenotypic trait of high genetic determinacy can also have a maximu ... | 2014 | 25711014 |
| tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine (sus scrofa domestica) as it relates to withdrawal methods for international export. | the use of water medications is a common practice in the us swine industry to treat and prevent infections in swine herds with minimal labor and without risk of needle breakage. there are concerns that fda-approved withdrawal times (wdt) may be inadequate for several water medications when exporting pork products to countries where mrls (maximum residue limits) are lower than us tolerance levels. in this study, withdrawal intervals (wdi) were estimated for pigs when dosed with tetracycline and s ... | 2015 | 25707857 |
| reproductive ratio for the local spread of african swine fever in wild boars in the russian federation. | african swine fever (asf) has caused the swine industry of the russian federation substantial economic losses over the last 7 years, and the disease spread from there to a number of neighbouring countries. wild boar has been involved in the spread of the disease both at local and at transboundary levels. understanding asf dynamics in wild boars is prerequisite to preventing the spread and to designing and applying effective surveillance and control plans. the reproductive ratio (r0) is an epidem ... | 2016 | 25704269 |
| evaluation of the plasmatic and parenchymal elution kinetics of two different irinotecan-loaded drug-eluting embolics in a pig model. | to evaluate and compare irinotecan elution kinetics of two drug-eluting embolic agents in a porcine model. | 2015 | 25704223 |
| changes in lens stiffness due to capsular opacification in accommodative lens refilling. | accommodation may be restored to presbyopic lenses by refilling the lens capsular bag with a soft polymer. after this accommodative lens refilling prevention of capsular opacification is a requirement, since capsular opacification leads to a decreased clarity of the refilled lens. it has been hypothesized that capsular fibrosis causing the capsular opacification results in increased stiffness of the lens capsular bag, therewith contributing to a decrease in accommodative amplitude of the lens. h ... | 2015 | 25704214 |
| bipolar multi-electrode balloon catheter radiofrequency renal denervation with the vessix system: preclinical safety evaluation. | a bipolar multi-electrode 7 fr-compatible balloon-catheter radiofrequency (rf) renal denervation system (vessix™ renal denervation system; boston scientific, marlborough, ma, usa) was evaluated for safety in domestic swine. | 2015 | 25701511 |
| epidemiology and molecular characterization of cryptosporidium spp. in humans, wild primates, and domesticated animals in the greater gombe ecosystem, tanzania. | cryptosporidium is an important zoonotic parasite globally. few studies have examined the ecology and epidemiology of this pathogen in rural tropical systems characterized by high rates of overlap among humans, domesticated animals, and wildlife. we investigated risk factors for cryptosporidium infection and assessed cross-species transmission potential among people, non-human primates, and domestic animals in the gombe ecosystem, kigoma district, tanzania. a cross-sectional survey was designed ... | 2015 | 25700265 |
| cardiac remodeling in a new pig model of chronic heart failure: assessment of left ventricular functional, metabolic, and structural changes using pet, ct, and echocardiography. | large animal models are needed to study disease mechanisms in heart failure (hf). in the present study we characterized the functional, metabolic, and structural changes of myocardium in a novel pig model of chronic myocardial infarction (mi) by using multimodality imaging and histology. | 2015 | 25698475 |
| randomized trial on the physiologic impact of notes. | our previous work revealed significantly less acidosis in swine undergoing natural orifice translumenal endoscopic surgery (notes) using endoscopic air insufflation than swine undergoing standard laparoscopy. we wanted to evaluate the differential effects of co2 versus intra-abdominal pressure as source for this finding. in addition, we investigated the endocrine stress response between swine undergoing notes peritoneoscopy with co2 insufflation and animals undergoing standard diagnostic laparos ... | 2015 | 25698397 |
| a taphonomic study exploring the differences in decomposition rate and manner between frozen and never frozen domestic pigs (sus scrofa). | this research examined differences in decomposition rate and manner of domestic pig subjects (sus scrofa) in never frozen (control) and previously frozen (experimental) research conditions. eight control and experimental subjects were placed in an identical outdoor research environment. daily quantitative and qualitative measurements were collected: abdominal circumference, total body score (tbs), temperature, photographs, descriptive decomposition stages, and visual observations. field necropsi ... | 2015 | 25693630 |
| immunization of african indigenous pigs with attenuated genotype i african swine fever virus ourt88/3 induces protection against challenge with virulent strains of genotype i. | the attenuated african swine fever virus genotype i strain ourt88/3 has previously been shown to induce protection of european breeds of domestic pigs against challenge with virulent isolates. to determine whether protective immune responses could also be induced in indigenous breeds of pigs from the kinshassa region in democratic republic of congo, we immunized a group of eight pigs with ourt88/3 strain and challenged the pigs 3 weeks later with virulent genotype i strain ourt88/1. four of the ... | 2016 | 25691347 |
| modeling cardiac arrest and resuscitation in the domestic pig. | cardiac arrest remains a leading cause of death and permanent disability worldwide. although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, ca(2+) overload, atp depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which ... | 2015 | 25685718 |
| catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine. | total body hypothermia is an established neuroprotectant in global cerebral ischemia. the role of hypothermia in acute ischemic stroke remains uncertain. selective application of hypothermia to a region of focal ischemia may provide similar protection with more rapid cooling and elimination of systemic side effects. we studied the effect of selective endovascular cooling in a focal stroke model in adult domestic swine. | 2016 | 25676148 |
| exposure of feral swine (sus scrofa) in the united states to selected pathogens. | feral swine (sus scrofa) are widely distributed in the united states. in 2011 and 2012, serum samples and tonsils were recovered from 162 and 37 feral swine, respectively, in the us to evaluate exposure to important swine endemic pathogens. antibodies against porcine reproductive and respiratory syndrome virus (prrsv) and porcine circovirus type 2 (pcv2) were found in 2.5% and 25.3% of tested sera, respectively. positive serological reactions against mycoplasma hyopneumoniae and actinobacillus p ... | 0 | 25673913 |
| domestic pigs are susceptible to infection with influenza b viruses. | influenza b virus (ibv) causes seasonal epidemics in humans. although ibv has been isolated from seals, humans are considered the primary host and reservoir of this important pathogen. it is unclear whether other animal species can support the replication of ibv and serve as a reservoir. swine are naturally infected with both influenza a and c viruses. to determine the susceptibility of pigs to ibv infection, we conducted a serological survey for u.s. midwest domestic swine herds from 2010 to 20 ... | 2015 | 25673727 |
| qtl for seed protein and amino acids in the benning × danbaekkong soybean population. | we identified qtl associated with protein and amino acids in a soybean mapping population that was grown in five environments. these qtl could be used in mas to improve these traits. soybean, rather than nitrogen-containing forages, is the primary source of quality protein in feed formulations for domestic swine, poultry, and dairy industries. as a sole dietary source of protein, soybean is deficient in the amino acids lysine (lys), threonine (thr), methionine (met), and cysteine (cys). increasi ... | 2015 | 25673144 |
| comparison of electrical current and ultrasonic device for incision of the septum of the pharyngoesophageal diverticulum in a pig model. | complications of endoscopic treatment of pharyngoesophageal diverticulum (ped) such as bleeding and perforation occur in up to 15 % of cases. our objective was to compare incision of the ped septum using the ultrasonic device (group h) with incision using electrical current (group m) in a pig model. | 2015 | 25669640 |
| detection of a new cluster of porcine circovirus type 2b strains in domestic pigs in germany. | pcv2 can be divided into three different genotypes: pcv2a, pcv2b and pcv2c. since 2004/2005 pcv2b has become the predominant genotype in the domestic pig population worldwide. in the years 2010 and 2012 pcv2b mutant strains (mpcv2), classified as pcv2b-1c strains, were detected in porcine circovirus diseases (pcvd) affected pigs in china and the united states, respectively. within one year (april 2013-april 2014) newly emerging mpcv2 strains were isolated in seven german pig farms routinely vacc ... | 2015 | 25669598 |
| genetic variation of the east balkan swine (sus scrofa) in bulgaria, revealed by mitochondrial dna and y chromosomal dna. | east balkan swine (ebs) sus scrofa is the only aboriginal domesticated pig breed in bulgaria and is distributed on the western coast of the black sea in bulgaria. to reveal the breed's genetic characteristics, we analysed mitochondrial dna (mtdna) and y chromosomal dna sequences of ebs in bulgaria. nucleotide diversity (πn ) of the mtdna control region, including two newly found haplotypes, in 54 ebs was higher (0.014 ± 0.007) compared with that of european (0.005 ± 0.003) and asian (0.006 ± 0.0 ... | 2015 | 25662601 |
| the effects of hemorrhagic shock secondary to hepatectomy in a swine model. | ischemia-reperfusion injury caused by severe hemorrhagic shock and subsequent resuscitation leads to deterioration of hepatic homeostasis and possibly to liver failure. the present study focuses on determining whether there is a different biological response to hemorrhagic shock by different sources of hemorrhage, hepatic hemorrhage (hh) versus peripheral hemorrhage. | 2015 | 25659614 |
| mechanism by which shock wave lithotripsy can promote formation of human calcium phosphate stones. | human stone calcium phosphate (cap) content correlates with higher urine cap supersaturation (ss) and urine ph as well as with the number of shock wave lithotripsy (swl) treatments. swl does damage medullary collecting ducts and vasa recta, sites for urine ph regulation. we tested the hypothesis that swl raises urine ph and therefore cap ss, resulting in cap nucleation and tubular plugging. the left kidney (t) of nine farm pigs was treated with swl, and metabolic studies were performed using bil ... | 2015 | 25656372 |
| gene coexpression networks reveal key drivers of phenotypic divergence in porcine muscle. | domestication of the wild pig has led to obese and lean phenotype breeds, and evolutionary genome research has sought to identify the regulatory mechanisms underlying this phenotypic diversity. however, revealing the molecular mechanisms underlying muscle phenotype variation based on differentially expressed genes has proved to be difficult. to characterize the mechanisms regulating muscle phenotype variation under artificial selection, we aimed to provide an integrated view of genome organizati ... | 2015 | 25651817 |
| pharmacokinetics of sustained-release and transdermal buprenorphine in göttingen minipigs (sus scrofa domestica). | the opioid buprenorphine has been shown to provide adequate postoperative analgesia in both companion and laboratory animals. however, its use is still hindered by the need for multiple parenteral injections to achieve continuous analgesia. the purpose of the current study was to conduct a pharmacokinetic analysis of 2 new long-acting formulations of buprenorphine-an injectable sustained-release buprenorphine (srb) and a transdermal buprenorphine (tdb) patch-in healthy göttingen minipigs by usin ... | 0 | 25650977 |
| domestic pigs' (sus scrofa domestica) use of direct and indirect visual and auditory cues in an object choice task. | recently, foraging strategies have been linked to the ability to use indirect visual information. more selective feeders should express a higher aversion against losses compared to non-selective feeders and should therefore be more prone to avoid empty food locations. to extend these findings, in this study, we present a series of studies investigating the use of direct and indirect visual and auditory information by an omnivorous but selective feeder-the domestic pig. subjects had to choose bet ... | 2015 | 25650328 |
| phenotype and animal domestication: a study of dental variation between domestic, wild, captive, hybrid and insular sus scrofa. | identifying the phenotypic responses to domestication remains a long-standing and important question for researchers studying its early history. the great diversity in domestic animals and plants that exists today bears testament to the profound changes that domestication has induced in their ancestral wild forms over the last millennia. domestication is a complex evolutionary process in which wild organisms are moved to new anthropogenic environments. although modern genetics are significantly ... | 2015 | 25648385 |
| inhibition of nitric oxide synthases, but not inducible nitric oxide synthase, selectively worsens left ventricular function after successful resuscitation from cardiac arrest in swine. | nitric oxide (no) is a critical regulator of vascular tone and signal transduction in the cardiovascular system. no is synthesized by three unique enzymes (nitric oxide synthases [nos]): endothelial and neuronal nos, both constitutively expressed, and inducible nos (inos), which is induced by proinflammatory stimuli and subsequently produces a burst of no. no has been implicated as both an injurious and a beneficial mediator after cardiac arrest and resuscitation. a previous study in swine found ... | 2015 | 25639298 |
| epidemiology of african swine fever in poland since the detection of the first case. | the purpose of this paper is to provide characteristics of the spread of african swine fever (asf) in poland from february to august, 2014. the samples from dead wild boar and domestic pigs were submitted to the national veterinary research institute, national reference laboratory for asf in pulawy, poland, for testing by pcr and elisa methods. in the studied period, fourteen cases of asf in wild boar and two outbreaks in backyard pigs were confirmed. in addition to the results of laboratory tes ... | 2014 | 25638980 |
| comparison of pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus between wild and domestic pigs. | the objective of this study was to compare the pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus (hp-prrsv) infection between wild and domestic pigs based on clinical, immunological, and pathological evaluation. upon challenge with hp-prrsv, five wild pigs died compared to none of the domestic. anti-prrsv antibody titers were significantly (p < 0.05) higher in wild hp-prrsv-infected pigs versus the domestic hp-prrsv-infected pigs at 21 days post inoculation ( ... | 2015 | 25634036 |