Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. | investigation of percutaneous helminth infection is generally based on animal models or excised skin. as desirable replacement of animal experiments, tissue-engineered skin equivalents have recently been applied in microbial and viral in vitro infection models. in the present study, the applicability of tissue-engineered skin equivalents for the investigation of percutaneous helminth invasion was evaluated. epidermal and a full-thickness skin equivalents that suit the requirements for helminth i ... | 2015 | 25592729 |
| genital schistosomiasis: a report on two cases of ovarian carcinomas containing viable eggs of schistosoma mansoni. | schistosomiasis is a parasitic infection that is highly prevalent worldwide, with a variety of species being responsible for causing the disease. in brazil, however, the only identified species is schistosoma mansoni. the adult parasites inhabit the blood vessels of the hepatic portal system of the main host. the disease may range from being asymptomatic to provoking liver damage or portal hypertension. furthermore, ectopic schistosomiasis may develop, and several hypotheses have been raised to ... | 2014 | 25587473 |
| activities of n,n'-diarylurea mmv665852 analogs against schistosoma mansoni. | there is an unmet need to discover and develop novel antischistosomal drugs. as exemplified by mmv665852, n,n'-diarylureas have recently emerged as a promising antischistosomal chemotype. in this study, we evaluated the structure-activity relationships of 46 commercially available analogs of mmv665852 on newly transformed schistosomula (nts) and adult schistosoma mansoni worms in vitro. active compounds were evaluated with a cytotoxicity assay, in silico calculations, metabolic stability studies ... | 2015 | 25583726 |
| epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. | keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated. here we address the hypothesis that cercariae activate epidermal keratinocytes to promote the development of a pro-inflammatory immune response in the skin. c57bl/6 mice were exposed to schistoso ... | 2015 | 25575749 |
| schistosomiasis presenting in travellers: a 15 year observational study at the hospital for tropical diseases, london. | schistosomiasis in returning travellers is one of the most common imported tropical infections with potentially serious complications, which are preventable if diagnosed early. | 2015 | 25575554 |
| isoforms of hsp70-binding human ldl in adult schistosoma mansoni worms. | schistosoma mansoni is one of the most common parasites infecting humans. they are well adapted to the host, and this parasite's longevity is a consequence of effective escape from the host immune system. in the blood circulation, lipoproteins not only help to conceal the worm from attack by host antibodies but also act as a source of lipids for s. mansoni. previous sem studies showed that the low-density lipoprotein (ldl) particles present on the surface of adult s. mansoni worms decreased in s ... | 2015 | 25573694 |
| in silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of schistosoma mansoni. | morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. because praziquantel is the only drug in therapeutic use, the risk of drug resistance is a concern. in the search for new schistosomicidal drugs, we performed a target-based chemogenomics screen of a dataset of 2,114 proteins to identify drugs that are approved for clinical use in humans that may be active against multiple life stages of schistosoma mansoni. each of these proteins was tr ... | 2015 | 25569258 |
| accelerated evolution of schistosome genes coding for proteins located at the host-parasite interface. | study of proteins located at the host-parasite interface in schistosomes might provide clues about the mechanisms utilized by the parasite to escape the host immune system attack. micro-exon gene (meg) protein products and venom allergen-like (val) proteins have been shown to be present in schistosome secretions or associated with glands, which led to the hypothesis that they are important components in the molecular interaction of the parasite with the host. phylogenetic and structural analysis ... | 2015 | 25567667 |
| intestinal schistosomiasis associated with intussusception: a case report. | we report a case of intestinal schistosomiasis associated with iliocaecal intussusception resulting from obstructions of the terminal part of the ileum by schistosome egg-induced fibrosis. a 7-year-old boy presented with the history of abdominal pain and difficulties in passing stool for two months. ultrasound examination revealed doughnut signs characterized with multiple concentric rings at the lateral abdomen, and the bowel loop appeared distended. exploratory laparatomy confirmed intussuscep ... | 2011 | 25566612 |
| sm16, a major component of schistosoma mansoni cercarial excretory/secretory products, prevents macrophage classical activation and delays antigen processing. | schistosoma mansoni cercariae penetrate the skin by releasing excretory/secretory (e/s) products known as 0-3hrp, which are associated with immune modulation through toll like receptor (tlr) signalling. furthermore, these secretions contain sm16, which when given to cells as a recombinant protein inhibits human monocyte derived cytokine responses to tlr4 and tlr3 ligands. nonetheless, the extent and mechanism(s) of these inhibitory effects remain largely uncharacterized. | 2015 | 25561160 |
| schistosome infection aggravates hcv-related liver disease and induces changes in the regulatory t-cell phenotype. | schistosome infections are renowned for their ability to induce regulatory networks such as regulatory t cells (treg) that control immune responses against homologous and heterologous antigens such as allergies. however, in the case of co-infections with hepatitis c virus (hcv), schistosomes accentuate disease progression and we hypothesized that expanding schistosome-induced treg populations change their phenotype and could thereby suppress beneficial anti-hcv responses. we therefore analysed e ... | 2015 | 25559085 |
| predicting the effects of climate change on schistosoma mansoni transmission in eastern africa. | survival and fitness attributes of free-living and sporocyst schistosome life-stages and their intermediate host snails are sensitive to water temperature. climate change may alter the geographical distribution of schistosomiasis by affecting the suitability of freshwater bodies for hosting parasite and snail populations. | 2015 | 25558917 |
| garcinielliptone fc: antiparasitic activity without cytotoxicity to mammalian cells. | garcinielliptone fc (gfc) is a natural prenylated benzophenone found in the seeds of platonia insignis mart. (clusiaceae), a native brazilian plant. it has been chemically characterized and it is known that gfc has several biological activities such as antioxidant and vasorelaxant properties. in this study, we report the in vitro effect of gfc against the blood fluke schistosoma mansoni, the parasite responsible for schistosomiasis mansoni. the anti-s. mansoni activity and cytotoxicity toward ma ... | 2015 | 25553916 |
| intestinal schistosomiasis and geohelminths of ukara island, north-western tanzania: prevalence, intensity of infection and associated risk factors among school children. | schistosoma mansoni and soil-transmitted helminths (sth) are among the most prevalent and highly neglected tropical diseases in tanzania. however, little is known on the distribution of these infections in rural settings, especially in the island areas on lake victoria. identifying the local risk factors of s. mansoni and soil-transmitted helminths is one step towards understanding their transmission patterns and will facilitate the design of cost-effective intervention measures. the present stu ... | 2014 | 25533267 |
| renal function in hepatosplenic schistosomiasis--an assessment of renal tubular disorders. | renal involvement in schistosoma mansoni infection is not well studied. the aim of this study is to investigate the occurrence of renal abnormalities in patients with hepatosplenic schistosomiasis (hss), especially renal tubular disorders. | 2014 | 25531759 |
| efficacy of synriam™, a new antimalarial combination of oz277 and piperaquine, against different developmental stages of schistosoma mansoni. | control of schistosomiasis relies on a single drug, praziquantel (pzq). given the rising concerns about the potential emergence of pzq-resistant strains, it has now become necessary to search for novel therapeutics. however, the current pace for anti-schistosomal drug discovery is slow; hence, repositioning of existing approved drugs can offer a safe, rapid and cost-effective solution. the anti-malarial synthetic artemisinin-derivatives trioxolanes demonstrated anti-schistosomal efficacies again ... | 2015 | 25530543 |
| bayesian risk mapping and model-based estimation of schistosoma haematobium-schistosoma mansoni co-distribution in côte d'ivoire. | schistosoma haematobium and schistosoma mansoni are blood flukes that cause urogenital and intestinal schistosomiasis, respectively. in côte d'ivoire, both species are endemic and control efforts are being scaled up. accurate knowledge of the geographical distribution, including delineation of high-risk areas, is a central feature for spatial targeting of interventions. thus far, model-based predictive risk mapping of schistosomiasis has relied on historical data of separate parasite species. | 2014 | 25522007 |
| high prevalence of schistosoma mansoni in six health areas of - kasansa health zone, democratic republic of the congo: short report. | school-aged children suffer the most from schistosomiasis infection in sub saharan africa due to poverty and limited sanitary conditions. mapping of disease burden is recommended and there is a need of updating prevalence data which is as old as 20 years in the democratic republic of congo. an epidemiological and parasitological study was carried out in 2011 in the health zone of kasansa. six health areas (ha) were included in the study. in each health area, one primary school was selected. scho ... | 2014 | 25521351 |
| schistosoma mansoni soluble egg antigens enhance t cell responses to a newly identified hiv-1 gag h-2b epitope. | schistosome infection induces significant t helper type 2 (th2) and anti-inflammatory immune responses and has been shown to negatively impact vaccine efficacy. our goal was to determine if the administration of schistosome soluble egg antigens (sea) would negatively influence the induction of cytotoxic t lymphocyte (ctl) and th1-type t cell responses to an hiv candidate vaccine in the th1-biased c57bl/6 mouse strain. initial experiments failed, as we were unable to detect any response to the de ... | 2015 | 25520148 |
| sustaining control of schistosomiasis mansoni in moderate endemicity areas in western côte d'ivoire: a score study protocol. | schistosomiasis is a parasitic disease that occurs in the tropics and subtropics. the mainstay of control is preventive chemotherapy with praziquantel. in africa, an estimated 230 million people require preventive chemotherapy. in western côte d'ivoire, infections with schistosoma mansoni are widespread. to provide an evidence-base for programme decisions about preventive chemotherapy to sustain control of schistosomiasis, a 5-year multi-country study with different treatment arms has been desig ... | 2014 | 25519880 |
| praziquantel sensitivity of kenyan schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug. | schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus schistosoma. while the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel. the near exclusive use of this drug for such a prevalent disease has led to concerns regarding the potential for drug resistance to arise and the effect this would have on affected populations. in this study, we use an in vitro assay of drug sensitivity to test the effect of p ... | 2014 | 25516840 |
| serum albumin and α-1 acid glycoprotein impede the killing of schistosoma mansoni by the tyrosine kinase inhibitor imatinib. | in the search for new drugs and drug targets to treat the flatworm disease schistosomiasis, protein kinases (pks) have come under particular scrutiny because of their essential roles in developmental and physiological processes in schistosome parasites. in this context the application of the anti-cancer abl tyrosine kinase (tk) inhibitor imatinib (gleevec/glivec; sti-571) to adult schistosoma mansoni in vitro has indicated negative effects on diverse physiological processes including survival. m ... | 2014 | 25516839 |
| compound library screening identified akt/pkb kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis. | protein kinases (pks) are one of the largest protein families in most eukaryotic organisms. these enzymes are involved in the control of cell proliferation, differentiation and metabolism and a large number of the anticancer drugs currently used are directed against pks. the structure and function of pks are well conserved throughout evolution. in schistosome parasites, pks were shown to be involved in essential functions at every stage of the parasite life cycle, making these enzymes promising ... | 2014 | 25516836 |
| comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: implications for potential anthelmintics. | pharmacological targeting of glutamate-gated chloride channels (glucls) is a potent anthelmintic strategy, evidenced by macrocyclic lactones that eliminate numerous roundworm infections by activating roundworm glucls. given the recent identification of flatworm glucls and the urgent need for drugs against schistosomiasis, flatworm glucls should be evaluated as potential anthelmintic targets. this study sought to identify agonists or modulators of one such glucl, smglucl-2 from the parasitic flat ... | 2014 | 25516835 |
| co-infection with schistosoma mansoni and human immunodeficiency virus-1 (hiv-1) among residents of fishing villages of north-western tanzania. | co-infection with s. mansoni and human immunodeficiency virus-1 (hiv-1) has been described in sub-saharan africa. however, few community-based studies have been conducted to assess the association between the two diseases. the present study examined whether the infection with hiv-1 is associated with an altered susceptibility to s. mansoni infection by comparing the prevalence and intensity of s. mansoni infection among those infected and not infected with hiv-1. any influence of hiv-1 associate ... | 2014 | 25511298 |
| parasitic infection among hiv/aids patients at bela-bela clinic, limpopo province, south africa with special reference to cryptosporidium. | intestinal parasitic organisms are common pathogens among hiv patients worldwide and have been known to cause severe and life-threatening diarrhea in such subjects. in the present study, the prevalence of cryptosporidium spp and other intestinal parasites in stool samples from 151 hiv/aids patients attending a hiv treatment center in south africa was determined using' standard parasitological methods, as well as molecular methods including pcr and quantitative pcr for confirmation of cryptospori ... | 2014 | 25507595 |
| community perceptions, attitude, practices and treatment seeking behaviour for schistosomiasis in l. victoria islands in uganda. | over 200,000 people, most of them infected with schistosoma mansoni inhabit 150 islands in lake victoria in uganda. although a programme to control the disease has been ongoing since 2003, its implementation in islands is inadequate due to high transport costs on water. in 2011 and 2012, the global network for neglected tropical diseases (gnntd) through schistosomiasis control initiative (sci) provided financial support to ease treatment delivery on the islands and over the period, therapeutic c ... | 2014 | 25495121 |
| schistosomiasis in malawi: a systematic review. | schistosomiasis remains an important public health problem that undermines social and economic development in tropical regions of the world, mainly sub-saharan africa. we are not aware of any systematic review of the literature of the epidemiology and transmission of schistosomiasis in malawi since 1985. therefore, we reviewed the current state of knowledge of schistosomiasis epidemiology and transmission in this country and identified knowledge gaps and relevant areas for future research and re ... | 2014 | 25490938 |
| lactate as a novel quantitative measure of viability in schistosoma mansoni drug sensitivity assays. | whole-organism compound sensitivity assays are a valuable strategy in infectious diseases to identify active molecules. in schistosomiasis drug discovery, larval-stage schistosoma allows the use of a certain degree of automation in the screening of compounds. unfortunately, the throughput is limited, as drug activity is determined by manual assessment of schistosoma viability by microscopy. to develop a simple and quantifiable surrogate marker for viability, we targeted glucose metabolism, which ... | 2015 | 25487803 |
| the relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis. | access to "safe" water and "adequate" sanitation are emphasized as important measures for schistosomiasis control. indeed, the schistosomes' lifecycles suggest that their transmission may be reduced through safe water and adequate sanitation. however, the evidence has not previously been compiled in a systematic review. | 2014 | 25474705 |
| health-related quality of life among school children with parasitic infections: findings from a national cross-sectional survey in côte d'ivoire. | parasitic infections are still of considerable public health relevance, notably among children in low- and middle-income countries. measures to assess the magnitude of ill-health in infected individuals, however, are debated and patient-based proxies through generic health-related quality of life (hrqol) instruments are among the proposed strategies. disability estimates based on hrqol are still scarce and conflicting, and hence, there is a need to strengthen the current evidence-base. | 2014 | 25474579 |
| biochemical and parasitological studies on the effect of hucb-selected cd34(+) progenitor/stem cells in mice infected with schistosoma mansoni. | placenta and blood that remained in the umbilical cord is routinely available as a discarded tissue after deliveries and it is free of any legal, moral, ethical or religious objections, providing a high number of multipotent cd34(+) progenitor and stem cells. using ex vivo isolated cd34(+) cells from human umbilical cord blood (hucb) have emerged as promising candidates to treat various diseases, including exogenous pathogenic infections. we have expanded to build a rational approach to study th ... | 2014 | 25473447 |
| infectious diseases in immigrant population related to the time of residence in spain. | the aim of this study was to evaluate the data on the main imported infectious diseases and public health issues arising from the risk of transmission of tropical and common diseases in the immigrant population. during the period of study, 2,426 immigrants were attended in the tropical medicine unit of the hospital of poniente. for each patient, a complete screening for common and tropical diseases was performed. the prevalence and main features of intestinal and urinary parasites, microfilarias ... | 2016 | 25466580 |
| 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis. | intrahepatic granuloma formation and fibrosis characterize the pathological features of schistosoma mansoni infection. based on previously observed substantial anti-fibrotic effects of 24-nor-ursodeoxycholic acid (norudca) in abcb4/mdr2(-/-) mice with cholestatic liver injury and biliary fibrosis, we hypothesized that norudca improves inflammation-driven liver fibrosis in s. mansoni infection. | 2015 | 25463533 |
| activation route of the schistosoma mansoni cathepsin b1 drug target: structural map with a glycosaminoglycan switch. | cathepsin b1 (smcb1) is a digestive protease of the parasitic blood fluke schistosoma mansoni and a drug target for the treatment of schistosomiasis, a disease that afflicts over 200 million people. smcb1 is synthesized as an inactive zymogen in which the n-terminal propeptide blocks the active site. we investigated the activation of the zymogen by which the propeptide is proteolytically removed and its regulation by sulfated polysaccharides (sps). we determined crystal structures of three molec ... | 2014 | 25456815 |
| intestinal schistosomiasis among preschool children along the shores of lake victoria in uganda. | schistosomiasis, a disease caused by schistosoma trematode parasites, affects hundreds of millions of people and accounts for more than 40% of the global health burden due to neglected tropical diseases. in uganda, intestinal schistosomiasis is endemic in 73 out of 112 districts and about 55% of the population of 36 million individuals are at risk. there is scanty information on the status and burden of schistosomiasis in preschool children less than six years of age in uganda. this study aimed ... | 2015 | 25454166 |
| evaluation of the immune response and protective efficacy of schistosoma mansoni cathepsin b in mice using cpg dinucleotides as adjuvant. | schistosomiasis is the most important human helminth infection due to its impact on public health. worldwide, schistosomiasis is estimated to infect at least 200 million individuals while 700 million are at risk. the clinical manifestations are chronic and significantly decrease an individual's quality of life. infected individuals suffer from long-term organ pathologies including fibrosis which eventually leads to organ failure. the development of a vaccine against this parasitic disease would ... | 2015 | 25448114 |
| comparative biochemical analysis of three members of the schistosoma mansoni tal family: differences in ion and drug binding properties. | the tegumental allergen-like (tal) proteins from schistosoma mansoni are part of a family of calcium binding proteins found only in parasitic flatworms. these proteins have attracted interest as potential drug or vaccine targets, yet comparatively little is known about their biochemistry. here, we compared the biochemical properties of three members of this family: smtal1 (sm22.6), smtal2 (sm21.7) and smtal3 (sm20.8). molecular modelling suggested that, despite similarities in domain organisatio ... | 2015 | 25447146 |
| treatment with egg antigens of schistosoma mansoni ameliorates experimental colitis in mice through a colonic t-cell-dependent mechanism. | helminth-derived molecules are being identified as a new therapeutic approach for immune-mediated diseases. we investigated the anti-inflammatory effect and the immunological mechanisms of schistosoma mansoni soluble egg antigens (smsea) in a mouse model of chronic colitis. | 2015 | 25437821 |
| parasitic infection among hiv/aids patients at bela-bela clinic, limpopo province, south africa with special reference to cryptosporidium. | intestinal parasitic organisms are common pathogens among hiv patients worldwide and have been known to cause severe and life-threatening diarrhea in such subjects. in the present study, the prevalence of cryptosporidium spp and other intestinal parasites in stool samples from 151 hiv/aids patients attending a hiv treatment center in south africa was determined using' standard parasitological methods, as well as molecular methods including pcr and quantitative pcr for confirmation of cryptospori ... | 2014 | 25427345 |
| field-derived schistosoma mansoni and biomphalaria pfeifferi in kenya: a compatible association characterized by lack of strong local adaptation, and presence of some snails able to persistently produce cercariae for over a year. | schistosoma mansoni is widely distributed in sub-saharan africa with biomphalaria pfeifferi being its most widespread and important snail intermediate host. few studies have examined the compatibility of field-derived b. pfeifferi snails with s. mansoni miracidia derived from human hosts. we investigated compatibility (as defined by shedding of cercariae following exposure to miracidia) of two isolates of s. mansoni from school children from asao (western kenya) and mwea (central kenya) with b. ... | 2014 | 25425455 |
| prevalence and its associated risk factors of intestinal parasitic infections among yadot primary school children of south eastern ethiopia: a cross-sectional study. | intestinal parasitic infections are posing significant morbidity worldwide. in ethiopia, due to poor socio-economic status, intestinal parasitic infections are highly prevalent. the main aim of this study was to determine the prevalence of intestinal parasites and its associated risk factors among yadot primary school children which is found in south-eastern part of ethiopia, in the district called delo-mena. | 2014 | 25425173 |
| effect of malaria and geohelminth infection on birth outcomes in kumasi, ghana. | in 2005, the ghana health service mandated malaria and helminths chemoprophylaxis during antenatal care visits. the aim of this study was to investigate the prevalence of malaria and helminth infections and their relationship with adverse birth outcomes (low birth weight, stillbirth, and preterm) following the implementation of these treatments. | 2014 | 25414840 |
| the population genetic structure of biomphalaria choanomphala in lake victoria, east africa: implications for schistosomiasis transmission. | the freshwater snail biomphalaria acts as the intermediate host of schistosoma mansoni, a globally important human parasite. understanding the population structure of intermediate host species can elucidate transmission dynamics and assist in developing appropriate control methods. | 2014 | 25406437 |
| distribution and abundance of schistosomiasis and fascioliasis host snails along the mara river in kenya and tanzania. | we purposively selected 39 sampling sites along the mara river and its two perennial tributaries of amala and nyangores and sampled snails. in addition, water physicochemical parameters (temperature, turbidity, dissolved oxygen, conductivity, alkalinity, salinity and ph) were taken to establish their influence on the snail abundance and habitat preference. out of the 39 sites sampled, 10 (25.6%) had snails. the snail species encountered included biomphalaria pfeifferi krauss - the intermediate h ... | 2014 | 25405008 |
| research and control of advanced schistosomiasis japonica in china. | among the three main schistosomes (schistosoma japonicum, schistosoma mansoni, and schistosoma haematobium) known to infect humans, s. japonicum causes the most serious pathological lesions. in china, only schistosomiasis japonica is transmitted. from the 1950s, massive epidemiological investigations and active control measures for schistosomiasis japonica have been carried out. at the early stage of schistosomiasis control program, there were about 12 million schistosomiasis patients, and about ... | 2015 | 25403379 |
| a tegument-specific venom allergen-like protein of clonorchis sinensis. | venom allergen-like (val) proteins, members of the scp/taps (sperm coating protein/tpx-1/ag5/pr-1/sc7) protein superfamily, have been reported from several parasitic helminths. as little is known about their biological functions, a val protein of the chinese liver fluke clonorchis sinensis was cloned and characterized. a complementary dna (cdna) encoding a 25-kda protein was identified from an est database of c. sinensis. a blast search revealed that the protein shares 46% sequence identity with ... | 2015 | 25403376 |
| gamma delta t cells in non-immune patients during primary schistosomal infection. | the mevalonate pathway is critical for the survival of schistosoma. γδ t cells, a small subset of peripheral blood (pb) t cells, recognize low molecular weight phosphorylated antigens in the mevalonate pathway, which drive their expansion to exert protective and immunoregulatory effects. to evaluate their role in schistosomiasis, we measured γδ t cells in the pb of non-immune travelers who contracted schistosoma hematobium or schistosoma mansoni in africa. the maximal level of γδ t-cells followi ... | 2014 | 25400925 |
| omega-1 knockdown in schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo. | schistosomiasis, one of the most important neglected tropical diseases worldwide, is caused by flatworms (blood flukes or schistosomes) that live in the bloodstream of humans. the hepatointestinal form of this debilitating disease results from a chronic infection with schistosoma mansoni or schistosoma japonicum. no vaccine is available to prevent schistosomiasis, and treatment relies predominantly on the use of a single drug, praziquantel. in spite of considerable research effort over the years ... | 2014 | 25400038 |
| s. mansoni bolsters anti-viral immunity in the murine respiratory tract. | the human intestinal parasite schistosoma mansoni causes a chronic disease, schistosomiasis or bilharzia. according to the current literature, the parasite induces vigorous immune responses that are controlled by th2 helper cells at the expense of th1 helper cells. the latter cell type is, however, indispensable for anti-viral immune responses. remarkably, there is no reliable literature among 230 million patients worldwide describing defective anti-viral immune responses in the upper respirator ... | 2014 | 25398130 |
| blastocystis and schistosomiasis coinfection in a patient with chronic kidney disease. | chronic kidney disease (ckd) and end-stage renal disease (esrd) represent a spectrum of impaired immunity with effects on cellular immunity, soluble immune factors, and inflammation. as a result, infections due to impaired immune system responses are responsible for significant morbidity in patients with kidney disease. because of immune dysfunction in ckd, these patients have reduced probability to clear infections and are susceptible to pathogenic effects of common organisms. we present a case ... | 2014 | 25389440 |
| high seroprevalence of echinococossis, schistosomiasis and toxoplasmosis among the populations in babati and monduli districts, tanzania. | the neglected tropical diseases, echinococcosis, schistosomiasis and toxoplasmosis are all globally widespread zoonotic diseases with potentially harmful consequences. there is very limited data available on the prevalence of these infections, except for schistosmiasis, in underdeveloped countries. this study aimed to determine the seroprevalence of echinococcus multilocularis, schistosoma mansoni, and toxoplasma gondii antibodies in populations from the monduli and babati districts in tanzania. | 2014 | 25388913 |
| effect of water temperature and population density on the population dynamics of schistosoma mansoni intermediate host snails. | mathematical models can be used to identify areas at risk of increased or new schistosomiasis transmission as a result of climate change. the results of these models can be very different when parameterised to different species of host snail, which have varying temperature preferences. currently, the experimental data needed by these models are available for only a few species of snail. the choice of density-dependent functions can also affect model results, but the effects of increasing densiti ... | 2014 | 25388819 |
| erratum to: the who ultrasonography protocol for assessing hepatic morbidity due to schistosoma mansoni. acceptance and evolution over 12 years. | 2015 | 25388671 | |
| gene suppression in schistosomes using rnai. | schistosomiasis is a neglected tropical disease responsible for the death of more than 300,000 people every year. the disease is caused by intravascular parasitic platyhelminths called schistosomes. treatment and control of schistosomiasis rely on a single drug, praziquantel, and concern exists over the possible emergence of resistance to this drug. the recent completion of the genome sequences of the three main worm species that cause schistosomiasis in humans has raised hope for the developmen ... | 2015 | 25388112 |
| helminth prevalence among adults in rural kenya: a stool survey for soil-transmitted helminths and schistosomiasis in nyanza province. | soil-transmitted helminth (sth) prevalence in children is high in rural southwestern kenya, but adult prevalence data are scarce. a 2010 study of a village in nyanza province found a pediatric sth prevalence of 44% using a direct stool-smear method. adult sth prevalence and associated predictors was measured in the same village. | 2014 | 25359321 |
| expression of corticotropin-releasing factor and urocortins in the normal and schistosoma mansoni-infected mouse ileum. | corticotropin-releasing factor (crf) and urocortins (ucns) are important ligands in the crf signaling pathways, which are most known for their role in the hypothalamic-pituitary-adrenal stress axis. however, peripheral crf signaling also has profound effects on gastrointestinal functions. although the murine animal model is highly relevant for the exploration of this complexly balanced pathway via genetic manipulation, little is known about the expression of crf and ucns in the mouse intestine. ... | 2015 | 25358399 |
| [dynamic transmission of schistosoma by biomphalaria pfeifferi in the region of man in côte d'ivoire]. | intestinal schistosomiasis by schistosoma mansoni is a parasitary affection transmitted in west africa by the mollusc biomphalaria pfeifferi. transmission dynamic of schistosomiasis by biomphalaria pfeifferi has seldom been investigated in côte d'ivoire. in the framework of a research project on the epidemiology of schistosomiasis in the natural forest ecosystems, this study was performed longitudinally over a period of three years in man region, in western côte d'ivoire. the trial set up from 1 ... | 2014 | 25351337 |
| schistosoma mansoni infection and undernutrition among school age children in fincha'a sugar estate, rural part of west ethiopia. | parasitic infection like schistosomiasis is known to exert a negative effect on nutritional status of school-aged children. however, studies associating parasitic infections with undernutrition are scarce. thus, this study was primarily to document the association between schistosoma mansoni infection and undernutrition among school-aged children in a rural setting of fincha'a sugar estate, ethiopia. | 2014 | 25348748 |
| [distribution and schistosomiasis transmission risks of biomphalaria straminea in inland china]. | biomphalaria straminea, the intermediary host of schistosoma mansoni, was found by survey in local areas of shenzhen city in 1981, which was the first finding of the snail in inland china. by 2013, the snail had spread in large range of shenzhen city and overspread to the surrounding regions, dongguan city and huizhou city. due to the facts that shenzhen city has many international communications and is a key area of labor export, with high population mobility, while the reports of s. mansoni in ... | 2014 | 25345144 |
| evaluation of real-time pcr assay to detect schistosoma mansoni infections in a low endemic setting. | schistosomiasis constitutes a major public health problem, and 200 million people are estimated to be infected with schistosomiasis worldwide. in brazil, schistosomiasis has been reported in 19 states, showing areas of high and medium endemicity and a wide range of areas of low endemicity (ale). barra mansa in rio de janeiro state has an estimated prevalence of 1%. ale represent a new challenge for the helminth control because about 75% of infected individuals are asymptomatic and infections occ ... | 2014 | 25338651 |
| impact of schistosoma mansoni on malaria transmission in sub-saharan africa. | sub-saharan africa harbors the majority of the global burden of malaria and schistosomiasis infections. the co-endemicity of these two tropical diseases has prompted investigation into the mechanisms of coinfection, particularly the competing immunological responses associated with each disease. epidemiological studies have shown that infection with schistosoma mansoni is associated with a greater malaria incidence among school-age children. | 2014 | 25329403 |
| fluorescence-based screening assays for the nad⁺-dependent histone deacetylase smsirt2 from schistosoma mansoni. | sirtuins are nad(+)-dependent histone deacetylases (hdacs) that cleave off acetyl but also other acyl groups from the ϵ-amino group of lysines in histones and other substrate proteins. five sirtuin isoforms are encoded in the genome of the parasitic pathogen schistosoma mansoni. during its life cycle, s. mansoni undergoes drastic changes in phenotype that are associated with epigenetic modifications. previous work showed strong effects of hsirt2 inhibitors on both worm life span and reproduction ... | 2015 | 25325257 |
| worm proteins of schistosoma mansoni reduce the severity of experimental chronic colitis in mice by suppressing colonic proinflammatory immune responses. | although helminthic therapy as a possible new option to treat inflammatory bowel disease is a well-established concept by now, the search for immunomodulatory helminth-derived compounds and their mechanisms of action is still ongoing. we investigated the therapeutic potential and the underlying immunological mechanisms of schistosoma mansoni soluble worm proteins (smswp) in an adoptive t cell transfer mouse model of chronic colitis. both a curative and a preventive treatment protocol were includ ... | 2014 | 25313594 |
| dendritic cell profile induced by schistosoma mansoni antigen in cutaneous leishmaniasis patients. | the inflammatory response in cutaneous leishmaniasis (cl), although responsible for controlling the infection, is associated with the pathogenesis of disease. conversely, the immune response induced by s. mansoni antigens is able to prevent immune-mediated diseases. the aim of this study was to evaluate the potential of the s. mansoni sm29 antigen to change the profile of monocyte-derived dendritic cells (modcs) from subjects with cutaneous leishmaniasis (cl) in vitro. monocytes derived from the ... | 2014 | 25309922 |
| epigenetic control of gene function in schistosomes: a source of therapeutic targets? | the discovery of the epigenetic regulation of gene expression has revolutionized both our understanding of how genomes function and approaches to the therapy of numerous pathologies. schistosomes are metazoan parasites and as such utilize most, if not all the epigenetic mechanisms in play in their vertebrate hosts: histone variants, histone tail modifications, non-coding rna and, perhaps, dna methylation. moreover, we are acquiring an increasing understanding of the ways in which these mechanism ... | 2014 | 25309576 |
| tumoral pulmonary mass secondary to schistosoma mansoni infection resembling neoplasia: case report. | patients with chronic schistosoma mansoni infection may feature a range of pulmonary symptoms and radiological findings. eggs, and rarely adult worms, may passively enter the pulmonary circulation, usually via the portal system, where they may cause pulmonary inflammation, fibrosis, hypertension and cor pulmonale. a 25-year-old patient who lived in a schistosomiasis endemic area with a pulmonary mass suggestive of malignancy underwent exploratory thoracotomy. the mass was adherent, with no resec ... | 2009 | 25307340 |
| the affinity of magnetic microspheres for schistosoma eggs. | schistosomiasis is a chronic parasitic disease of humans, with two species primarily causing the intestinal infection: schistosoma mansoni and schistosoma japonicum. traditionally, diagnosis of schistosomiasis is achieved through direct visualisation of eggs in faeces using techniques that lack the sensitivity required to detect all infections, especially in areas of low endemicity. a recently developed method termed helmintex™ is a very sensitive technique for detection of schistosoma eggs and ... | 2015 | 25305086 |
| no apparent reduction in schistosome burden or genetic diversity following four years of school-based mass drug administration in mwea, central kenya, a heavy transmission area. | schistosomiasis is a debilitating neglected tropical disease that infects over 200 million people worldwide. to combat this disease, in 2012, the world health organization announced a goal of reducing and eliminating transmission of schistosomes. current control focuses primarily on mass drug administration (mda). therefore, we monitored transmission of schistosoma mansoni via fecal egg counts and genetic markers in a typical school based mda setting to ascertain the actual impacts of mda on the ... | 2014 | 25299057 |
| schistosomiasis manifesting as a colon polyp: a case report. | schistosomiasis is a rare disease with a common intestinal involvement. however, colon polyps associated with schistosoma in the absence of inflammation have rarely been reported, especially in young people; this is the first case with the following presentation. | 2014 | 25296942 |
| prevalence of intestinal parasitic infections among children under five years of age with emphasis on schistosoma mansoni in wonji shoa sugar estate, ethiopia. | intestinal parasite infections are major public health problems of children in developing countries causing undernutrition, anemia, intestinal obstruction and mental and physical growth retardation. this study was conducted to assess the prevalence of intestinal helminthic infections among children under five years of age with emphasis on schistosoma mansoni in wonji shoa sugar estate, ethiopia. a cross-sectional parasitological survey was conducted in under-five children living in wonji shoa su ... | 2014 | 25296337 |
| spotlight on the in vitro effect of artemisinin-naphthoquine phosphate on schistosoma mansoni and its snail host biomphalaria alexandrina. | malaria and schistosomiasis are the two most important parasitic diseases in the tropics and sub-tropics with geographic overlap. efforts have been made for developing new schistosomicidal drugs, or testing existing drugs originally used for non-related diseases. the antimalarial artemisinin-naphthoquine phosphate combination (co-arnp) was recently reported to be a promising novel antischistosomal therapy with potent in vivo activity against schistosoma mansoni. in this work, we report the in vi ... | 2015 | 25291045 |
| in vitro interactions between the defense systems of resistant and susceptible biomphalaria alexandrina and sporocysts of schistosoma mansoni. | biomphalaria species that act as an intermediate host for schistosoma mansoni have different degrees of susceptibility and different internal defense system responses against parasites. of these species, biomphalaria alexandrina represents the only intermediate host in egypt. given the limited data on the efficacy of the b. alexandrina internal defense system in comparison to that of other species, we sought to better understand its defense against s. mansoni. we performed in vitro hemocyte adhe ... | 2014 | 25277545 |
| expression profile of the schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets. | blood fluke proteases play pivotal roles in the processes of invasion, nutrition acquisition, immune evasion, and other host-parasite interactions. hundreds of genes encoding putative proteases have been identified in the recently published schistosome genomes. however, the expression profiles of these proteases in schistosoma species have not yet been systematically analyzed. we retrieved and culled the redundant protease sequences of schistosoma japonicum, schistosoma mansoni, echinococcus mul ... | 2014 | 25275570 |
| acute paraplegia caused by schistosoma mansoni. | 2014 | 25274599 | |
| propolis enhances the effectiveness of praziquantel in experimental schistosomiasis: biochemical and histopathological study. | despite the wide current use of praziquantel (pzq) in treatment of schistosomiasis, low cure rates have been recorded in many studies. the aim of this study was directed to evaluate the curative effect of propolis (pps) alone or in combination with pzq on biochemical, immunological, parasitological, and histological changes associated with experimental schistosomiasis in mice. schistosoma mansoni-infected mice were divided into two experimental sets, each with four subgroups: (i) untreated, (ii) ... | 2014 | 25266217 |
| the who ultrasonography protocol for assessing hepatic morbidity due to schistosoma mansoni. acceptance and evolution over 12 years. | the aim of this study is to review the worldwide acceptance of the world health organization (who) ultrasound protocol for assessing hepatosplenic morbidity due to schistosoma mansoni since its publication in 2000. a pubmed literature research using the keywords "schistosomiasis and ultrasound," "schistosomiasis and ultrasonography," and "s. mansoni and ultrasound" from 2001 to 2012 was performed. case reports, reviews, reports on abnormalities due to parasites other than s. mansoni, organ invol ... | 2014 | 25260691 |
| use of humanised rat basophilic leukaemia cell line rs-atl8 for the assessment of allergenicity of schistosoma mansoni proteins. | parasite-specific ige is thought to correlate with protection against schistosoma mansoni infection or re-infection. only a few molecular targets of the ige response in s. mansoni infection have been characterised. a better insight into the basic mechanisms of anti-parasite immunity could be gained from a genome-wide characterisation of such s. mansoni allergens. this would have repercussions on our understanding of allergy and the development of safe and efficacious vaccinations against helmint ... | 2014 | 25254513 |
| high schistosoma mansoni disease burden in a rural district of western zambia. | schistosoma mansoni disease is endemic in most parts of rural zambia, and associated complications are common. we conducted a cross-sectional study among 754 people in rural communities of kaoma district, western zambia to determine the burden of s. mansoni infection and associated morbidity. parasitology and ultrasonography assessments were conducted on consenting participants. the overall prevalence of s. mansoni infection and geometric mean egg count (gmec) were 42.4% (304) and 86.6 eggs per ... | 2014 | 25246696 |
| efficacy and safety of arachidonic acid for treatment of schistosoma mansoni-infected children in menoufiya, egypt. | arachidonic acid (ara), an omega-6 fatty acid, kills juvenile and adult schistosomes in vitro and displays highly significant and safe therapeutic effects in mice and hamsters infected with schistosoma mansoni or s. haematobium. this study aims to examine the efficacy and safety of ara in treatment of school-age children infected with s. mansoni. in total, 66 s. mansoni-infected schoolchildren (20-23 children/study arm) received a single dose of 40 mg/kg praziquantel (pzq), ara (10 mg/kg per day ... | 2014 | 25246692 |
| synthesis and activity of new triphenylphosphonium derivatives of betulin and betulinic acid against schistosoma mansoni in vitro and in vivo. | we studied the antischistosomal activity of betulin, betulinic acid and its 9 triphenylphosphonium derivatives characterized by a covalently linkage of the hydrophobic fragment of triterpenoid at c(2)- or c(30)-position with the triphenylphosphonium moiety via a hydrocarbon bridge. the triphenylphosphonium salts showed in vitro antischistosomal activity against newly transformed schistosomula (nts) and adult worms of schistosoma mansoni at low micromolar concentrations. in contrast betulin and b ... | 2014 | 25245671 |
| discovery of inhibitors of schistosoma mansoni hdac8 by combining homology modeling, virtual screening, and in vitro validation. | schistosomiasis, caused by s. mansoni, is a tropical disease that affects over 200 million people worldwide. a novel approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for the extensive phenotypic changes during their life cycle. we recently identified s. mansoni histone deacetylase 8 (smhdac8) as a potential target for antiparasitic therapy. here we present results from a virtual screening campaign on smhdac8. besides hydroxamates, seve ... | 2014 | 25243797 |
| two smdlc antigens as potential vaccines against schistosomiasis. | the schistosoma mansoni transcriptome revealed new members of the dynein light chain family (dlc/lc8). the antigenicity and immunogenicity of these proteins, and their potential as vaccine candidates were investigated. two dlc genes (dlc12_ji392413.1 and dlc13_ji387686.1) were cloned and the recombinant proteins produced in e. coli. the immunization of mice with the rdlcs, using alhydrogel as adjuvant, resulted in high titers of antibodies, indicated that these proteins are highly immunogenic. t ... | 2014 | 25240208 |
| comparison of the in vitro effects of one-day exposure to amodiaquine and praziquantel on schistosoma mansoni adult worm pairs. | it has been demonstrated that continuous exposure to amodiaquine (aq) alone elicits in vitro antischistosomal activities at concentrations of 1-10 μg/ml. however, orally administered drugs reach a peak blood concentration within one or two hours and then gradually decrease. the blood concentration does not remain at a constant level over several days as in vitro concentration of continuous drug exposure. in vitro activities by one day exposure to aq better reflect the actual antischistosomal act ... | 2014 | 25237285 |
| fucoidan stimulates cell division in the amebocyte-producing organ of the schistosome-transmitting snail biomphalaria glabrata. | adult salvador (schistosome-resistant) strain biomphalaria glabrata snails were injected with 5 μl of 10 mg/ml solutions of the sulfated polysaccharides λ carageenan, dextran sulfate, fucoidan, and heparin, the nonsulfated polysaccharide laminarin, and the monosaccharides l-fucose and l-galactose, and mitotic activity in the amebocyte-producing organ (apo) was measured in histological sections at 24 h post injection. among the substances tested, only fucoidan induced elevated mitotic activity. d ... | 2014 | 25233872 |
| a malacological survey in the manso power plant, state of mato grosso, brazil: new records of freshwater snails, including transmitters of schistosomiasis and exotic species. | schistosomiasis is a parasitic disease of public health concern in brazil, and the construction of hydroelectric dams, in addition to increasing permanent human settlement and tourism, has created conditions suitable for the establishment of mollusks that can transmit schistosomiasis. such areas require a number of actions to prevent the establishment of schistosomiasis. this paper reports on a freshwater malacological survey carried out in the geographical area of the manso power plant. | 2014 | 25229292 |
| reciprocal effects of schistosoma mansoni infection on spontaneous autoimmune arthritis in il-1 receptor antagonist-deficient mice. | schistosome infections have been shown to prevent inflammation in induced-type arthritis models. however, its effects on spontaneous arthritis remain unknown. we here investigated the effects of schistosoma mansoni (sm) infection on spontaneous autoimmune arthritis in il-1 receptor antagonist (il-1ra)-deficient mice. sm infection partially reduced the severity of arthritis in male il-1ra-deficient mice. the splenic responses of il-17 and tnf-α were reduced, while those of il-4 and il-10 were enh ... | 2015 | 25220583 |
| characterization of α-l-fucosidase and other digestive hydrolases from biomphalaria glabrata. | schistosoma mansoni is one of the major agents of the disease schistosomiasis, which is one of the major global public health concerns. biomphalaria glabrata is an obligate intermediate mollusc host of s. mansoni. although the development of s. mansoni occurs in the snail hepatopancreas, studies that focus on this organ remain limited. in this study, we biochemically identified five distinct carbohydrases (amylase, maltase, α-glucosidase, trehalase, and α-l-fucosidase), lipases, and peptidases i ... | 2015 | 25218034 |
| differential spatial repositioning of activated genes in biomphalaria glabrata snails infected with schistosoma mansoni. | schistosomiasis is an infectious disease infecting mammals as the definitive host and fresh water snails as the intermediate host. understanding the molecular and biochemical relationship between the causative schistosome parasite and its hosts will be key to understanding and ultimately treating and/or eradicating the disease. there is increasing evidence that pathogens that have co-evolved with their hosts can manipulate their hosts' behaviour at various levels to augment an infection. bacteri ... | 2014 | 25211244 |
| incomplete deletion of il-4rα by lysm(cre) reveals distinct subsets of m2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. | mice expressing a cre recombinase from the lysozyme m-encoding locus (lyz2) have been widely used to dissect gene function in macrophages and neutrophils. here, we show that while naïve resident tissue macrophages from il-4rαf(lox/delta)lysm(cre) mice almost completely lose il-4rα function, a large fraction of macrophages elicited by sterile inflammatory stimuli, schistosoma mansoni eggs, or s. mansoni infection, fail to excise il4rα. these f4/80(hi)cd11b(hi) macrophages, in contrast to resident ... | 2014 | 25211233 |
| sensitivity and specificity of multiple kato-katz thick smears and a circulating cathodic antigen test for schistosoma mansoni diagnosis pre- and post-repeated-praziquantel treatment. | two kato-katz thick smears (kato-katzs) from a single stool are currently recommended for diagnosing schistosoma mansoni infections to map areas for intervention. this 'gold standard' has low sensitivity at low infection intensities. the urine point-of-care circulating cathodic antigen test (poc-cca) is potentially more sensitive but how accurately they detect s. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts re ... | 2014 | 25211217 |
| screening the life cycle of schistosoma mansoni using high-resolution mass spectrometry. | schistosomiasis is a common tropical disease caused by schistosoma species schistosomiasis' pathogenesis is known to vary according to the worms' strain. moreover, high parasitical virulence is directly related to eggs release and granulomatous inflammation in the host's organs. this virulence might be influenced by different classes of molecules, such as lipids. therefore, better understanding of the metabolic profile of these organisms is necessary, especially for an increased potential of unr ... | 2014 | 25201273 |
| furofuran lignans display schistosomicidal and trypanocidal activities. | parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. this paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively. their schistosomicidal, trypanocidal, and leishmanicidal activities were evaluated in vitro against schistosoma mansoni adult worms, trypomastigote and amastigotes forms of try ... | 2014 | 25200100 |
| structural and catalytic effects of an invariant purine substitution in the hammerhead ribozyme: implications for the mechanism of acid-base catalysis. | the hammerhead ribozyme catalyzes rna cleavage via acid-base catalysis. whether it does so by general acid-base catalysis, in which the rna itself donates and abstracts protons in the transition state, as is typically assumed, or by specific acid-base catalysis, in which the rna plays a structural role and proton transfer is mediated by active-site water molecules, is unknown. previous biochemical and crystallographic experiments implicate an invariant purine in the active site, g12, as the gene ... | 2014 | 25195740 |
| in vitro and in vivo antischistosomal activity of ferroquine derivatives. | schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. the ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. the aim of the present work was to study the antischistosomal activity of ferroquine against schistosoma mansoni adult worms and newly transformed schistosomula (nts) in vitro and in vivo. hydroxyl-ferroquine and ruthenoquine were included to study the poten ... | 2014 | 25190030 |
| a loop-mediated isothermal amplification (lamp) assay for early detection of schistosoma mansoni in stool samples: a diagnostic approach in a murine model. | human schistosomiasis, mainly due to schistosoma mansoni species, is one of the most prevalent parasitic diseases worldwide. to overcome the drawbacks of classical parasitological and serological methods in detecting s. mansoni infections, especially in acute stage of the disease, development of cost-effective, simple and rapid molecular methods is still needed for the diagnosis of schistosomiasis. a promising approach is the loop-mediated isothermal amplification (lamp) technology. compared to ... | 2014 | 25187956 |
| evaluation and updating of the medical malacology collection (fiocruz-cmm) using molecular taxonomy. | the medical malacology collection (coleção de malacologia médica, fiocruz-cmm) is a depository of medically relevant mollusks, especially from the genus biomphalaria, which includes the hosts of schistosoma mansoni. taxonomic studies of these snails have traditionally focused on the morphology of the reproductive system. however, determination of some species is complicated by the similarity shown by these characters. molecular techniques have been used to try to overcome this problem. | 2014 | 25184111 |
| status of schistosoma mansoni prevalence and intensity of infection in geographically apart endemic localities of ethiopia: a comparison. | schistosomiasis is one of the chronic and neglected tropical diseases affecting rural communities. heavy infections contribute to anemia and can retard children's growth, physical activity and cognitive function. this study was conducted in order to determine the prevalence, intensity and variation of schistosoma mansoni infection among human subjects in geographically apart localities. the prevalence and intensity of schistosoma mansoni infection was assessed in three geographically apart endem ... | 2014 | 25183924 |
| community awareness of intestinal parasites and the prevalence of infection among community members of rural abaye deneba area, ethiopia. | to assess the knowledge of abaye deneba community members regarding intestinal parasites and prevalence of intestinal parasitic infections. | 2014 | 25183071 |
| t cell-derived il-4/il-13 protects mice against fatal schistosoma mansoni infection independently of basophils. | schistosomiasis is a severe and chronic disease caused by the parasitic trematode schistosoma mansoni after deposition of eggs in the liver and intestines. the immune response to s. mansoni eggs is characterized by increased th2 cells, eosinophilia, and high serum ige levels. granulomas are formed around the eggs to protect the organs against tissue damage caused by toxic products that are secreted from the eggs. egg-derived components have further been shown to activate the ige-mediated release ... | 2014 | 25172500 |