Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| studies on the effects of biomedicinal agents on serum concentration of ca2+, p and alp activity in osteoporosis-induced rats. | the present study was carried out to investigate the effects of biomedicinal agents on ca2+, p and alkaline phosphatase (alp) levels in ovariectomized rats. rats were ovariectomized bilaterally and were fed up with ca2+ and p-free diet during 8(9,10) weeks to induce osteoporosis. osteoporosis was determined by the extent of bone density and by lowering the concentrations of serum ca2+, p and alp activity every week. rats in antler, safflower, ipriflavon, or co-administrated with estrogen groups ... | 2003 | 14610368 |
| conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumen. | effects of dietary conjugated linoleic acids (clas) and docosahexaenoic acid (dha) on the fatty acid composition of different egg compartments after storage were studied. four dietary treatments [supplemented with safflower oil (saff, control group), dha, clas plus dha (cad), and clas alone] were administered to single comb white leghorn (scwl) laying hens. eggs from the different treatment groups were collected and stored for 10 weeks at 4 degrees c before analysis. fatty acids from the yolk (y ... | 2003 | 14582988 |
| a novel and potent biological antioxidant, kinobeon a, from cell culture of safflower. | kinobeon a was originally isolated from cultured cells of safflower (carthamus tinctorius l., compositae). it had never previously been directly isolated from safflower or other plants, animals or microorganisms. in this report, we demonstrate the anti-oxidative effects of kinobeon a and compare the results with those two known natural antioxidants, lignan (nordihydroguaiaretic acid) and quercetin. the nadph-induced microsomal lipid peroxidation system was employed to assess anti-oxidative effec ... | 2003 | 14575815 |
| lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip)-induced mammary carcinogenesis in female sprague-dawley rats. | tracheloside, one of the plant lignans which can be extracted from the debris after safflower oil is produced from the seeds of carthamus tinctorious, is an analogue of another plant lignan, arctiin, the side-chain c-2 of the five-membered ring being changed from a hydrogen to a hydroxyl group. we have already demonstrated that arctiin has chemopreventive effect on mammary carcinogenesis. therefore, chemopreventive effects of tracheloside on the initiation or post-initiation period of 2-amino-1- ... | 2003 | 14568166 |
| microreactor for methanolysis of triglycerides before gas-liquid chromatography. | a rapid, accurate microtechnique has been developed for gas chromatographic determination of the fatty acid composition of small (2-3 micro l) samples of vegetable oils. this microtechnique combines transesterification and sample injection into a single operation. the fatty acid compositions of soybean, linseed, and safflower oils thus determined are compared with those obtained by the usual two-step procedure. | 1967 | 14564723 |
| effect of neonatal rat bisphenol a exposure on performance in the morris water maze. | bisphenol a (bpa), an environmental estrogen, is a component of many food and beverage containers and can leach into the container contents over time. due to its estrogenic properties, exposure to bpa during development could alter the appropriate maturation of pathways essential for normal cognitive function at later ages. to investigate this, the effects of repeated postnatal exposure of male and female rats to bpa on spatial learning and memory were investigated using a morris water maze. bre ... | 2003 | 14555403 |
| element analysis and biological studies on ten oriental spices using xrf and ames test. | ten oriental spices were analyzed for their element composition using x-ray fluorescence (xrf): nutmeg (myristica fragrans), coriander (coriandrum sativum), safflower (carthamus tinctorius), caraway (carum carvi), sicilian sumac (rhus coriaria), aniseed (anisum vulgare), black pepper (piper nigrum), cardamom (elettaria cardamomum), cumin (cuminum cyminum) and nigella (nigella sativum). the spices were found to contain the following elements: mg, al, si, p, s, cl, k, ca, ti, mn, fe, cu and zn, wi ... | 2003 | 14531636 |
| [effect of type of dietary fat and ethanol on hepatic leukotriene level in experimental alcoholic liver disease]. | the purpose of our study is to determine if a relationship exists between the severity of injury in experimental alcoholic liver disease and hepatic levels of leukotriene b4, leukotriene c4 and lipid peroxide. splague-dawley rats were fed ethanol (46% of calories) with either safflower oil (se) or beef oil (be) (20% of calories) for 12 weeks. control animals were fed isocaloric amounts of dextrose instead of ethanol with the same diets. the followings were evaluated in each group: hepatic levels ... | 2003 | 14515744 |
| physicochemical stability of intravenous lipid emulsions as all-in-one admixtures intended for the very young. | intravenous lipid emulsions (ivles) are unstable when growth of lipid droplets into large fat globules is detected by appropriate particle sizing techniques. specifically, instability is evident when the volume-weighted percent fat (pfat)>5 microm exceeds 0.4% of the total lipids present. this represents an approximate 10-fold increase in the population normally present in the large-diameter tail of stable lipid emulsions. the composition of the oil phase of an ivle, however, has been shown to e ... | 2003 | 14512037 |
| dietary fish oil decreases c-reactive protein, interleukin-6, and triacylglycerol to hdl-cholesterol ratio in postmenopausal women on hrt. | atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear. | 2003 | 14505813 |
| studies on the nutritional aspects of hydrogenated tobacco seed and safflower seed oils. | 1961 | 14448662 | |
| the effect of safflower oil on serum lipids. | 1960 | 14438294 | |
| effect of safflower and coconut oils upon plasma cholesterol and lipid fractions. | 1960 | 14428532 | |
| comparison between the effects of pork fat and safflower oil on serum lipids and atherosclerosis in cholesterol-fed chickens. | 1960 | 14427198 | |
| regression studies with safflower oil and sitosterol in rabbit atherosclerosis. | 1959 | 14422548 | |
| utilization of safflower meal by the chick and its effect upon plasma lysine and methionine concentrations. | 1965 | 14344018 | |
| cholesterol metabolism. 3. enhancement of cholesterol absorption and accumulation in safflower oil-fed rats. | 1964 | 14233150 | |
| synthesis of linoleic acid by particulate system from safflower seeds. | 1964 | 14196780 | |
| safflower: utilization and significance in nutrition and allergy. | 1964 | 14104253 | |
| treatment of hypercholesterolemic patients with niacin, sitosterol and safflower oil. | 1960 | 13858018 | |
| the effect of safflower oil on blood lipid and protein levels in glycogen storage disease of the liver. | 1960 | 13839150 | |
| comparison of the treatment of hypercholesteremia with nicotinic acid, sitosterol, and safflower oil. | 1959 | 13799273 | |
| the effect of safflower oil on the nature of serum cholesterol esters. | 1960 | 13792624 | |
| the effect of safflower oil upon serum lipids and proteins in juvenile diabetes mellitus. | 1961 | 13777834 | |
| plasma fibrinolysis in man: the effect of chylomicrons derived from different dietary fats. | the plasma fibrinolytic activity, measured in vitro, of 17 healthy normal young males was consistently and equally inhibited by prior ingestion of equal amounts of either a relatively saturated animal fat (butterfat) or a highly unsaturated vegetable fat (safflower oil). this effect was further studied by the addition of purified chylomicrons derived from ingestion of either butterfat, safflower oil, or egg yolk to an in vitro system. the inhibitory effect was quantitatively similar in all exper ... | 1961 | 13698247 |
| circulating leptin levels in newborn rats: a significant post- natal developmental effect, independent of dietary polyunsaturated fat levels. | leptin expression exhibits developmental and dietary regulation, but it is unknown whether there is an interaction of the regulation by dietary fat and postnatal development. the purpose of this study was to test the effect of different levels of dietary polyunsaturated fat on circulating leptin levels at different post-natal developmental stages. pregnant (sprague-dawley) rats consumed from day 15 of pregnancy through day 9 of lactation a low fat, (11% of energy; lf) polyunsaturated safflower o ... | 2003 | 13679243 |
| safflower oil. | 1959 | 13640967 | |
| safflower oil-pyridoxine and corn oilpyridoxine emulsions; their effect on serum cholesterol levels in young adult males when used as supplements to a normal diet. | 1959 | 13640926 | |
| the result of treatment of hypercholesterolemia associated with atherosclerosis with sitosterol and safflower oil derivatives. | 1958 | 13564045 | |
| effect of safflower oil on serum cholesterol and lipoproteins in patients on a low-fat diet. | 1958 | 13562473 | |
| response of serum lipids and lipoproteins o man to beta-sitosterol and safflower oil; a longterm study. | 1958 | 13537276 | |
| effect of safflower oil emulsion on serum cholesterol levels in young adult males; its use as a supplement to a normal diet. | 1958 | 13525187 | |
| influence of a safflower oil emulsion on serum cholesterol level. | 1957 | 13472575 | |
| on the formation of carthamin in the flowers of carthamus tinctorius. | 1955 | 13229360 | |
| the effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. | the effect of polyunsaturated fatty acids (pufa), in particular conjugated linoleic acid (cla), on ca and bone metabolism is unclear. in a 2x2 factorial design study, forty male 4-week-old rats were fed a control diet containing 70 g added fat (soyabean oil (sbo; n-6 pufa-rich diet) or menhaden oil-safflower oil (mso; n-3 pufa-rich diet))/kg diet with 0 or 10 g cla/kg for 8 weeks. ex vivo prostaglandin e2 biosynthesis by bone organ culture was significantly higher (p<0.001) in rats consuming sbo ... | 2003 | 13129442 |
| protective effect of supplementation of fish oil with high n-3 polyunsaturated fatty acids against oxidative stress-induced dna damage of rat liver in vivo. | the present study was undertaken to know the effect of supplementation of fish oil with high n-3 polyunsaturated fatty acids (pufa) on oxidative stress-induced dna damage of rat liver in vivo. male wistar rats were fed a diet containing fish oil or safflower oil with high n-6 pufa at 50 g/kg of diet and an equal amount of vitamin e at 59 mg/kg of diet for 6 weeks. livers of rats fed fish oil were rich in n-3 pufa, whereas those of rats fed safflower oil were rich in n-6 pufa. ferric nitrilotriac ... | 2003 | 13129319 |
| classification of edible oils by employing 31p and 1h nmr spectroscopy in combination with multivariate statistical analysis. a proposal for the detection of seed oil adulteration in virgin olive oils. | a combination of (1)h nmr and (31)p nmr spectroscopy and multivariate statistical analysis was used to classify 192 samples from 13 types of vegetable oils, namely, hazelnut, sunflower, corn, soybean, sesame, walnut, rapeseed, almond, palm, groundnut, safflower, coconut, and virgin olive oils from various regions of greece. 1,2-diglycerides, 1,3-diglycerides, the ratio of 1,2-diglycerides to total diglycerides, acidity, iodine value, and fatty acid composition determined upon analysis of the res ... | 2003 | 12952424 |
| developmental transition of the flavonoid contents in safflower leaves during stress-loaded cultivation. | we have previously reported that strong visible light with limited water caused a significant increase in the polyphenol contents of safflower seedlings (carthamus tinctrius l.), suggesting that the appropriate stress loading could be applied to effectively cultivate flavonoid-rich plants. in this present study, we investigated in detail the time-dependent transition in the flavonoid contents of safflower leaves during the stress-loaded cultivation. in the cotyledons, the light/water stress cont ... | 2003 | 12951501 |
| effect of supplementation of n-3 polyunsaturated fatty acids on oxidative stress-induced dna damage of rat hepatocytes. | the effect of supplementation of n-3 polyunsaturated fatty acids (pufa) on oxidative stress-induced dna damage of rat hepatocytes was examined. male wistar rats were fed a diet containing safflower oil (control n-6 pufa diet) or fish oil (n-3 pufa diet) in 50 g/kg of dried diet and an equal amount of vitamin e in 59 mg/kg of dried diet for 6 weeks. the liver of rats fed safflower oil was rich in n-6 pufa, whereas that of rats fed fish oil was rich in n-3 pufa. isolated hepatocytes were treated i ... | 2003 | 12951465 |
| impact of dietary n-3 fa deficiency on rat bone tissue fa composition. | the effect of dietary n-3 fa deficiency on bone tissue fa composition was evaluated in growing rats. two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (la). the n-3 treatments were formulated with added alpha-linolenic acid (lna) from flaxseed oil (diet lna) or lna plus dha, and both were balanced for la. this study showed that bone is sensitive to changes in dietary n-3 fa and that dha is mo ... | 2003 | 12934680 |
| representations of the texture of food in the primate orbitofrontal cortex: neurons responding to viscosity, grittiness, and capsaicin. | the primate orbitofrontal cortex (ofc) is a site of convergence from taste, olfactory, and somatosensory cortical areas. we describe a population of single neurons in the macaque ofc that responds to the texture of food in the mouth. use of oral viscosity stimuli consisting of carboxymethylcellulose (cmc) in the range 1-10,000 centipoise showed that the responses of one subset of these neurons were related to stimulus viscosity. some of the neurons had increasing responses to increasing viscosit ... | 2003 | 12917386 |
| meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. | high intake of red meat, but not of white meat, is associated with an increased risk of colon cancer. however, red meat does not promote cancer in rodents. haemin, added to low-calcium diets, increases colonic proliferation, and haemoglobin, added to high-fat diets, increases the colon tumour incidence in rats, an effect possibly due to peroxyl radicals. we thus speculated that haem might be the promoting agent in meat, and that prevention strategies could use calcium and antioxidants. these hyp ... | 2003 | 12896910 |
| effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. | oxidative stress is presumed to play an important role in hepatic fibrogenesis. diets high in polyunsaturated fatty acids (pufa) enhance fibrosis and have been associated with increased oxidative damage in some models of liver injury. the aim of this study was to determine the effects of dietary fat of varying pufa content on iron-induced oxidative stress and fibrosis. | 2003 | 12895262 |
| [determination of adenosine, rutin and quercetin in carthamus tinctorius by hpce]. | to develop a method for determination of adenosine, rutin and quercetin in carthamus tinctorius l. by high performance capillary electrophoresis(hpce). | 2003 | 12889129 |
| replacing 40% of dietary animal fat with vegetable oil is associated with lower hdl cholesterol and higher cholesterol ester transfer protein in cynomolgus monkeys fed sufficient linoleic acid. | this study was designed to evaluate whether replacing approximately 40 g/100 g dietary animal fat with vegetable oil would improve plasma lipids and lipoproteins when diets contained prudent levels of total saturated acid (sfa), monounsaturated acid (mufa) and pufa. using a cross-over design, male cynomolgus monkeys (n = 10) were fed purified diets containing a mixture of fats. for the diet based on animal fat (af-diet), approximately 85 g/100 g of the total fat was derived from pork fat, and ap ... | 2003 | 12888644 |
| amelioration of tacrolimus-induced nephrotoxicity in rats using juniper oil. | calcineurin-inhibitor nephrotoxicity plays a role in the pathogenesis of chronic allograft nephropathy by causing renal ischemia mediated by vasoconstrictive metabolites of the prostanoid pathway. the purpose of our study was to evaluate whether altering the prostanoid profile using juniper oil (jo) would afford renoprotection in rats treated with tacrolimus. | 2003 | 12883183 |
| nutritional evaluation of structured lipid containing omega 6 fatty acid synthesized from coconut oil in rats. | coconut oil is rich in medium chain fatty acids, but deficient in polyunsaturated fatty acids (pufa). structured lipids (sl) enriched with omega 6 pufa were synthesized from coconut oil triglycerides by employing enzymatic acidolysis with free fatty acids obtained from safflower oil. rats were fed a diet containing coconut oil, coconut oil-safflower oil blend (1:0.7 w/ w) or structured lipid at 10% levels for a period of 60 days. the sl lowered serum cholesterol levels by 10.3 and 10.5% respecti ... | 2003 | 12870651 |
| dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (dmba) and 1,2-dimethylhydrazine (dmh) in female sprague-dawley rats. | to clarify the chemopreventive effects of conjugated fatty acid derived from safflower oil (cfa-s), rich in conjugated linoleic acid (cla), on mammary and colon carcinogenesis, 6 week old female sprague-dawley (sd) rats received diet containing 0.01, 0.05, 0.1, 1, or 2% cfa-s subsequent to five times subcutaneous injections of 1,2-dimethyl-hydrazine (dmh) at a dose of 40 mg/kg b.w. and a single 50 mg/kg b.w. intragastric application of 7,12-dimethylbenz[a]anthracene (dmba) during the first 11 da ... | 2003 | 12860274 |
| cholecystokinin-a receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested. | the hypothesis of these studies was that all fats and carbohydrates suppress food intake, at least in part, via cholecystokinin-a receptors (cckar). fat (coconut oil, beef tallow, olive and safflower oil) and carbohydrate (cornstarch, sucrose, glucose and fructose) preloads were given intragastrically (1 g/4 ml) 30 min before feeding. devazepide (0.25 mg/kg), a cckar antagonist, was given intraperitoneally at 60 or 30 min before or with each of the macronutrient preloads. devazepide reversed foo ... | 2003 | 12840200 |
| the 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in oletf rats. | we investigated the effect of conjugated linoleic acid (cla) on energy metabolism in otsuka long-evans tokushima fatty (oletf) rats. | 2003 | 12831953 |
| dietary alpha-linolenic acid decreases c-reactive protein, serum amyloid a and interleukin-6 in dyslipidaemic patients. | inflammation plays an important role in the pathogenesis of coronary artery disease. we examined whether dietary supplementation with alpha-linolenic acid (ala, 18:3n-3) affects the levels of inflammatory markers in dyslipidaemic patients. | 2003 | 12818406 |
| protective effects of cvpm on vascular endothelium in rats fed cholesterol diet. | the cardiovascular protective mixture (cvpm) is a concoction of nine chinese traditional medicines: dan-shen root, szechwan lovge rhizome, chinese angelica, hawthorn fruit, safflower, peach seed, red peony root, earthworm, and membranous milkvetch root. these medicines are used to cure cardiovascular disease in china. | 2003 | 12809739 |
| cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. | hypocholesterolemic activity of dietary polyunsaturated fatty acids is observed after relatively short-term but not long-term feedings, and their long-term feedings are suspected to accelerate aging through tissue accumulation of lipid peroxides and age pigments (lipofuscin). to define the long-term effects of fats and oils in more detail, female mice were fed a conventional basal diet supplemented with lard (lar), high-linoleic (n-6) safflower oil (saf), rapeseed oil (rap), high-alpha-linolenic ... | 2003 | 12808283 |
| safety of an astaxanthin-rich haematococcus pluvialis algal extract: a randomized clinical trial. | a growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin e and may confer numerous health benefits. the purpose of this investigation was to conduct a human safety study with a haematococcus pluvialis algal extract with high levels of astaxanthin. thirty-five healthy adults age 35-69 years were enrolled in a randomized, double-blind, placebo-controlled trial of 8 weeks' duration. all participants took three gelcaps per d ... | 2003 | 12804020 |
| kinobeon a as a potent tyrosinase inhibitor from cell culture of safflower: in vitro comparisons of kinobeon a with other putative inhibitors. | kinobeon a is produced from cell cultures of the medicinal plant, safflower. mushroom tyrosinase activity was inhibited in a concentration-dependent manner when treated with kinobeon a using l-tyrosine or l-3,4-dihydroxyphenylalannine (l-dopa) as substrates. ic50 values were 22 microm (substrate: l-tyrosine) and 27 microm (l-dopa). inhibition of human tyrosinase activity also increased with increasing concentrations of kinobeon a using l-dopa as the substrate, with an ic50 value of 2.5 microm. k ... | 2003 | 12802729 |
| neuroprotective effects of hydroxysafflor yellow a: in vivo and in vitro studies. | previous work has shown that hydroxysafflor yellow a (hsya), extracted from carthamus tinctorius l. markedly extended the coagulation time in mice and exhibited a significant antithrombotic effect in rats. the present study was conducted to demonstrate further its neuroprotective effects on cerebral ischemic injury in both in vivo and in vitro studies. in vivo, male wistar-kyoto (wky) rats with middle cerebral artery occlusion (mcao) were evaluated for neurological deficit scores followed by the ... | 2003 | 12802724 |
| [study on free radical mechanism of guanxin ii in antagonizing ischemic myocardial damage]. | to study comparatively the effect of guanxin ii and its constituents, including salvia, red peony root, chuanxiong, safflower and dalbergia wood, in scavenging active oxygen free radical (ofr) to explore their mechanism in overcoming the experimental acute ischemic myocardial injury and protecting myocardial tissue. | 2003 | 12800420 |
| progesterone increases susceptibility of gilts to uterine infections after intrauterine inoculation with infectious bacteria. | in cattle and sheep, a progestogenated uterus is susceptible to infections, but this is not well documented for pigs. therefore, the effects of day of the estrous cycle and progesterone on the susceptibility to uterine infections were evaluated. gilts (n = 5 per group) were assigned to treatments in 2 x 2 factorial arrays. in exp. 1, day of cycle and bacterial challenge were main effects. on d 0 or 8, uteri were inoculated with either 70 x 10(7) cfu of escherichia coli and 150 x 10(7) cfu of arc ... | 2003 | 12772852 |
| neurons in the primate orbitofrontal cortex respond to fat texture independently of viscosity. | the primate orbitofrontal cortex (ofc) is a site of convergence from primary taste, olfactory, and somatosensory cortical areas. we describe the responses of a population of single neurons in the ofc that respond to orally applied fat (e.g., safflower oil) and to substances with a similar texture but different chemical composition, such as mineral oil (hydrocarbon) and silicone oil [(si(ch3)2o)n]. these findings provide evidence that the neurons respond to the oral texture of fat, sensed by the ... | 2003 | 12761278 |
| tissue-mimicking oil-in-gelatin dispersions for use in heterogeneous elastography phantoms. | a ten-month study is presented of materials for use in heterogeneous elastography phantoms. the materials consist of gelatin with or without a suspension of microscopic safflower oil droplets. the highest volume percent of oil in the materials is 50%. thimerosal acts as a preservative. the greater the safflower oil concentration, the lower the young's modulus. elastographic data for heterogeneous phantoms, in which the only variable is safflower oil concentration, demonstrate stability of inclus ... | 2003 | 12747425 |
| reduced fatty acid synthesis and desaturation due to exogenous trans10,cis12-cla in cows fed oleic or linoleic oil. | to determine effects of an elevated supply of cis9,trans11-18:2 (9/11cla) or trans10,cis12-18:2 (10/12cla) on de novo synthesis and desaturation of long-chain fatty acids, four holstein cows fed high-oleic sunflower (ole) or high-linoleic safflower oil (lin) at 2.5% of dm were infused (0.625 g/h) with 9/11cla or 10/12cla for 48 h via the abomasum. treatments were assigned in a 2 x 2 factorial design. the assigned diets were fed for 11 d before each 48-h infusion period. milk samples were obtaine ... | 2003 | 12741561 |
| short communication: postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in holstein cows. | in view of the potential of rumen-protected conjugated linoleic acid (cla) as a means to increase the cla content of bovine milk, a study was undertaken to evaluate the effect of synthetic cla on milk production and composition. four holstein cows received abomasal infusion of: 1) control, no lipid infusion, 2) 150 g/d of synthetic cla, 31.7% cis-9, trans-11; 30.4% trans-10, cis-12, 3) 150 g/d of safflower oil, and 4) 150 g/d of tallow. infusion was carried out for 20 to 22 h/d for 11-d periods ... | 2003 | 12741557 |
| dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in l1210 leukemic mice. | the purpose of this study was to investigate whether dietary supplementation with the n-3 fatty acid docosahexaenoic acid (dha) in combination with arabinosylcytosine (arac) chemotherapy could prolong the life expectancy of mice bearing l1210 leukemia. the four control diets included rodent chow, a diet containing 5% of a blended oil mimicking the fatty acid composition of rodent chow, and diets containing 5% or 10% fat with safflower oil as the main oil source. the two dha-supplemented diets pr ... | 2002 | 12734065 |
| reduced bone mineralization in infants fed palm olein-containing formula: a randomized, double-blinded, prospective trial. | palm and palm olein (po) oils are used in some infant formula fat blends to match the fatty acid profile of human milk, but their presence has been shown to lower calcium and fat absorption. we aimed to determine if the reported differences in calcium absorption could affect skeletal development by comparing bone mineral accretion in healthy term infants fed a milk-based formula with (pmf) or without po. | 2003 | 12728082 |
| effects of feeding supplemental fat to beef cows on cold tolerance in newborn calves. | our objectives were to examine the effects of added fat in late-gestation cow diets on neonatal response to cold. in exp. 1, pregnant fall-calving heifers received control (n = 5), safflower seed (n = 5), or whole cottonseed (n = 5) diets. the hay-based, isonitrogenous, and isocaloric diets, fed for 47 d prepartum, contained 1.5, 4.0, and 5.0% fat for control, safflower, and whole cottonseed diets, respectively. at calving, calf bw and vigor score, as well as fat, lactose, and igg in colostrum w ... | 2003 | 12723076 |
| temporal association of ca(2+)-dependent protein kinase with oil bodies during seed development in santalum album l.: its biochemical characterization and significance. | calcium-dependent protein kinase (cdpk) is expressed in sandalwood (santalum album l.) seeds under developmental regulation, and it is localized with spherical storage organelles in the endosperm [anil et al. (2000) plant physiol. 122: 1035]. this study identifies these storage organelles as oil bodies. a 55 kda protein associated with isolated oil bodies, showed ca(2+)-dependent autophosphorylation and also cross-reacted with anti-soybean cdpk. the cdpk activity detected in the oil body-protein ... | 2003 | 12721377 |
| effect of a mixture of conjugated linoleic acid isomers on growth performance and antibody production in broiler chicks. | the effect of dietary conjugated linoleic acid (cla) isomers mixture on antibody titres against sheep blood erythrocytes (srbc) and immunoglobulin (ig) g concentration in plasma was studied in broiler chickens. in experiment 1, male and female broiler chicks (11 d of age, cobb strain) were fed a diet supplemented with 10 g cla or 10 g safflower-seed oil/kg diet for 2 weeks. an srbc suspension (5:100, v/v) in a phosphate buffer was intravenously injected at 18 d of age and a blood sample was take ... | 2003 | 12720589 |
| effect of altered dietary n-6-to-n-3 fatty acid ratio on erythrocyte lipid composition and membrane-bound enzymes. | three experimental diets with varied n-6-to-n-3 fatty acid ratios (120, 40 and 8) were prepared by a suitable blending of safflower oil containing 72.5% linoleic (18:2 n-6) acid and non-detectable levels of alpha-linolenic (18:3 n-3) acid, and soybean oil having 56.1% linoleic (18:2 n-6) acid and 7.9% alpha-linolenic (18:3 n-3) acid. these diets were fed to weanling female wistar/nin (inbred) rats for 16 wk to assess the impact of altered dietary n-6-to-n-3 fatty acid ratio on erythrocyte membra ... | 2002 | 12656209 |
| fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of srebp-1 expression. | hamsters were fed a control diet or diets containing palm, olive, safflower, or fish oil for 2 weeks. in villus cell populations from duodenum, jejunum, and ileum, rates of intestinal fatty acid and cholesterol synthesis were estimated, as were sterol regulatory element-binding protein (srebp)-1a, srebp-1c, srebp-2, hmg-coa synthase, fatty acid synthase, atp citrate lyase, acetyl-coa carboxylase mrna levels, and srebp-1 and srebp-2 mass. plasma cholesterol and triacylglcerol levels were increase ... | 2003 | 12639972 |
| effects of fish oil in parenteral nutrition. | fish oil is a rich source of omega-3 fatty acids (fas), especially eicosapentaenoic acid and docosahexaenoic acid. the existing data suggest that eicosapentaenoic acid and docosahexaenoic acid are the active agents in fish oil. a number of clinical trials have shown that dietary fish oil supplementation has antiatherogenic properties and immunomodulation effects. fish oils are not used widely in parenteral nutrition because fish oil emulsions have not been commercially available until very recen ... | 2003 | 12620534 |
| ntp comparative toxicology studies of corn oil, safflower oil, and tricaprylin (cas nos. 8001-30-7, 8001-23-8, and 538-23-8) in male f344/n rats as vehicles for gavage. | the types and levels of fats in the diet are known to affect the incidence of certain neoplasms in humans and rodents. in long-term toxicity and carcinogenicity studies in rodents, the level of dietary fat is altered by using oil as a vehicle to administer unpalatable or volatile chemicals. control male rats receiving a corn oil vehicle have a higher incidence of pancreatic proliferative lesions and a lower incidence of mononuclear cell leukemia than untreated control males. therefore, the natio ... | 1994 | 12616305 |
| palm oil: biochemical, physiological, nutritional, hematological, and toxicological aspects: a review. | the link between dietary fats and cardiovascular diseases has necessitated a growing research interest in palm oil, the second largest consumed vegetable oil in the world. palm oil, obtained from a tropical plant, elaeis guineensis contains 50% saturated fatty acids, yet it does not promote atherosclerosis and arterial thrombosis. the saturated fatty acid to unsaturated fatty acid ratio of palm oil is close to unity and it contains a high amount of the antioxidants, beta-carotene, and vitamin e. ... | 2002 | 12602939 |
| multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by n-(p-coumaroyl)serotonin and its derivatives. | we have reported that n-(p-coumaroyl)serotonin(cs) isolated from safflower oil cake (carthamus tinctorius l.) inhibits the production of proinflammatory cytokines by endotoxin (lps)- stimulated human monocytes. in this study, the effects of cs and its three derivatives, n-(trans-cinnamoyl)serotonin (cin.s), n-(trans-cinnamoyl)tryptamine (cin.t), and n-(p-coumaroyl)tryptamine (ct) on the production of proinflammatory cytokines were compared. cin.s possessed radical scavenging activity at a compar ... | 2003 | 12586608 |
| [comparative study on effect of recipe for activating blood circulation and replenishing qi on left ventricular remodeling in rats with left heart failure after myocardial infarction]. | comparative study to the effect of chinese herbal medicine on left ventricular remodeling in rats with left heart failure after myocardial infarction (mi). | 2002 | 12584842 |
| effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats. | to investigate whether dietary fatty acid (fa) composition and energy restriction (er) interactively influence obese (ob) gene expression, rats consumed diets containing beef tallow, safflower, or fish oil ad libitum (al) or at 60% al intake. circulating leptin concentrations were higher (p < 0.0001) after al feeding, but were not influenced by dietary fat. er decreased (p < 0.0001) weight gain and visceral adipose weight, which were positively correlated (r = 0.40 p < 0.001, r = 0.58 p < 0.0001 ... | 2003 | 12562868 |
| omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. | omega-3 fatty acids (fas) reduce postprandial triacylglycerol (tg) concentrations. this study was undertaken to determine whether this effect was due to reduced production or increased clearance of chylomicrons. healthy subjects (n = 33) began with a 4-week, olive oil placebo (4 g/d) run-in period. after a 4-week wash-out period, subjects were randomized to supplementation with 4 g/d of ethyl esters of either safflower oil (saf), eicosapentaenoic acid (epa), or docosahexaenoic acid (dha) for 4 w ... | 2003 | 12562865 |
| dietary fat modulation of apoa-ii metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse. | senescence-accelerated mouse-prone (samp1; samp1@umz) is an animal model of senile amyloidosis with apolipoprotein a-ii (apoa-ii) amyloid fibril (aapoaii) deposits. this study was undertaken to investigate the effects of dietary fats on aapoaii deposits in samp1 mice when purified diets containing 4% fat as butter, safflower oil, or fish oil were fed to male mice for 26 weeks. the serum hdl cholesterol was significantly lower (p < 0.01) in mice on the diet containing fish oil (7.4 +/- 3.0 mg/dl) ... | 2003 | 12562830 |
| the effect of safflower seed extract on periodontal healing of 1-wall intrabony defects in beagle dogs. | recent interest in naturally based products has increased. various herbal extracts are known to have a variety of medicinal properties. among the various natural medicines, safflower seeds have beneficial effects on various bone diseases such as bone fracture, osteoporosis, and osteodysplasia. in addition, they are known to have anti-inflammatory effects. the objective of this study was to evaluate the effect of a safflower seed extract (sse) on the regeneration of periodontal tissue in a precli ... | 2002 | 12546096 |
| epa, but not dha, decreases mean platelet volume in normal subjects. | the first indication of platelet activation is an increase in mean platelet volume (mpv). n-3 fa are known to inhibit platelet function and to reduce the risk for coronary heart disease. the purpose of this study was to determine the effects of epa and dha on mpv. healthy subjects received olive oil placebo for 4 wk and then were randomly assigned to receive 4 g of ethyl esters of either safflower oil (n = 11), epa (n = 10), or dha (n = 12) for 4 wk. at the end of placebo run-in and treatment pe ... | 2002 | 12530552 |
| teratogenic actions of thermally-stressed culinary oils in rats. | lipid oxidation products (lops), generated in culinary oils during episodes of thermal stressing can give rise to cellular damage. the aims of this study were to determine whether orally-administered, lop-containing thermally-stressed safflower oil exerts teratogenic actions in rats, and whether this effect could be prevented by co-administration of alpha-tocopherol (alpha-toh). safflower oil was heated for a period of 20 min according to standard frying practices and stored at -20 degrees c und ... | 2002 | 12516875 |
| the conjugated linoleic acid (cla) isomer, t10c12-cla, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. | isomers of conjugated linoleic acid (cla) are found in beef, lamb and dairy products. diets containing cla reduce adipose mass in various depots of experimental animals. in addition, cla delays the onset of diabetes in the zdf rat model for obesity-linked type 2 diabetes mellitus. we hypothesize that there would be an inverse association of cla with body weight and serum leptin in subjects with type 2 diabetes mellitus. in this double-blind study, subjects with type 2 diabetes mellitus were rand ... | 2003 | 12514304 |
| body fat accumulation is greater in rats fed a beef tallow diet than in rats fed a safflower or soybean oil diet. | the effects of dietary fats , consisting of different fatty acids, on body fat accumulation and uncoupling protein (ucp) in interscapular brown adipose tissue were studied in rats. metabolisable energy in experimental diets based on safflower oil, soybean oil or beef tallow was measured strictly (experiment 1). male wistar rats were then meal-fed an isoenergetic diet for 8 weeks (experiment 2). each group of rats showed the same weight gain during the 8-week experimental period. carcass fat cont ... | 2002 | 12495263 |
| oral fat exposure increases the first phase triacylglycerol concentration due to release of stored lipid in humans. | oral exposure to dietary fat (through modified sham feeding, which entails mastication and expectoration of foods) augments the postprandial triacylglycerol (tag) concentration, in part, though augmented lipid absorption. this study was designed to characterize early events in this process. at 2200 h, 25 healthy adults (13 men, 12 women) consumed 80 g of almonds (high oleic acid content) and fasted until approximately 0700 h. after placement of a catheter in a hand vein and 4 blood draws at 10-m ... | 2002 | 12468603 |
| rhamnolipid biosurfactant production by strains of pseudomonas aeruginosa using low-cost raw materials. | this study was aimed at the development of economical methods for higher yields of biosurfactant by suggesting the use of low-cost raw materials. two oil-degrading strains, pseudomonas aeruginosa gs9-119 and ds10-129, were used to optimize a substrate for maximum rhamnolipid production. among the two strains, the latter produced maxima of 4.31, 2.98, and 1.77 g/l rhamnolipid biosurfactant using soybean oil, safflower oil, and glycerol, respectively. the yield of biosurfactant steadily increased ... | 2002 | 12467462 |
| supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | tocotrienols have been reported to lower ldl-cholesterol and fasting glucose concentrations and to have potent antioxidant effects, but the results are contradictory. | 2002 | 12450888 |
| dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. | male sprague-dawley rats, trained to consume their daily energy needs in a single 3-h meal (0900-1200 h), were used to examine the hypothesis that polyunsaturated fatty acids (pufa) lowered the nuclear content of sterol regulatory element binding protein (srebp)-1 and/or -2 by suppressing the proteolytic release of mature srebp from the membrane-anchored precursor pool. the nuclear concentrations of hepatic srebp-1 and -2 were 50 and 42% lower (p < 0.05) in rats that consumed a single pufa-suppl ... | 2002 | 12421847 |
| long-term effect of fish oil diet on basal and stimulated plasma glucose and insulin levels in ob/ob mice. | in this study, the ob/ob mouse model was used to investigate epidemiological evidence linking fish intake to relative reduction in incidence of type 2 diabetes mellitus and glucose. we have investigated, in comparison to low and high fat diets, the effect of a fish oil diet on basal and stimulated plasma glucose and insulin levels in male and female ob/ob mice. mice were fed for 12 months with a saturated fat diet containing 25% lard, with a low fat diet containing 5% soybean oil, with a polyuns ... | 2002 | 12416657 |
| long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer. | animal studies suggest that dietary polyunsaturated fatty acids (pufas) of the n-6 class, found in corn and safflower oils, may be precursors of intermediates involved in the development of mammary tumors, whereas long-chain (lc) n-3 pufas, found in fish oil, can inhibit these effects. this case-control study was designed to examine the relationship between the pufa composition of breast adipose tissue and the risk of breast cancer. using fatty acid levels in breast adipose tissue as a biomarker ... | 2002 | 12416257 |
| olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed. | compared with the postprandial events after a single meal, different events occur when a second meal is ingested 4-6 h after a first meal. there is a rapid appearance of chylomicrons in the circulation carrying fat ingested with the first meal, with a peak 1 h after the second meal. | 2002 | 12399264 |
| novel experimental protocol to increase specific plasma nonesterified fatty acids in humans. | this study reports a novel protocol to increase plasma monounsaturated, polyunsaturated, and saturated nonesterified fatty acids (nefa) in eight healthy volunteers (age 29-54 yr, body mass index 23-26 kg/m(2)). this was achieved by feeding small boluses of fat at different time points (35 g at 0 min and 8 g at 30, 60, 90, 120, 150, 180, and 210 min) in combination with a continuous low-dose heparin infusion. olive oil, safflower oil, or palm stearin were used to increase monounsaturated, polyuns ... | 2003 | 12388155 |
| release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: the effect of meals rich in olive and safflower oils. | triglyceride-rich lipoproteins increase net transport of cell cholesterol to postprandial plasma from healthy subjects after a meal rich in fat and cholesterol. the aim of the present study was to determine the effect of meals rich in polyunsaturated fats (pufa) and monounsaturated fats (mufa) and low in cholesterol on net in vitro transport of cholesterol from red blood cells (rbcs) to postprandial plasma from 21 men with mild to moderate hypercholesterolemia in a randomized, crossover trial. c ... | 2002 | 12370851 |
| gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. | as dietary sources of gamma-linolenic acid [gla; 18:3(n-6)], borage oil (bo; 24-25 g/100 g gla) and evening primrose oil (po; 8-10 g/100 g gla) are efficacious in treating skin disorders. the triglycerol stereospecificity of these oils is distinct, with gla being concentrated in the sn-2 position of bo and in the sn-3 position of po. to determine whether the absolute level and/or the triglycerol stereospecificity of gla in oils affect biological efficacy, epidermal hyperproliferation was induced ... | 2002 | 12368400 |
| different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 1. effects of linoleic and linolenic acid provided via different oil sources on total antibody (ab) titres, ab isotypes after primary and secondary immunisation, and cutaneous hypersensitivity (ch) responses to bovine serum albumin (bsa) and maleyl-bsa, respectively, were studied in pullets fed on one of 4 diets. the diets were the basal control diet enriched with either sunflower oil or safflower oil as sources of linoleic acid, and linseed oil as a source of linolenic acid, tested against a co ... | 2002 | 12365510 |
| short-term administration of conjugated linoleic acid reduces liver triglyceride concentration and phosphatidate phosphohydrolase activity in oletf rats. | the present study explored the short-term effects of dietary conjugated-linoleic acid (cla) on liver lipid metabolism in starved/refed otsuka long evans tokushima fatty (oletf) rats. male oletf rats (12 weeks old) were starved for 24 hours, then refed for 48 hours with either a cla diet [7.5% cla and 7.5% safflower oil (saf)] or a saf control diet (15% saf). the results demonstrated a 30% reduction of hepatic triglyceride (tg) concentration in the cla group when compared to the control group. li ... | 2002 | 12359092 |
| safflower polysaccharides activate the transcription factor nf-kappa b via toll-like receptor 4 and induce cytokine production by macrophages. | two active polysaccharide fractions (sf1 and sf2) purified from dried safflower petals (carthamus tinctorius l.) stimulated the synthesis of various cytokines by peritoneal macrophages. in a number of cell types, sf1 and sf2 induced a rapid degradation of ikappab alpha essential for the activation of the transcription factor nf-kappab. toll-like receptor 4 (tlr4), but not tlr2, was expressed in all cell lines that responded to sf1 and sf2. enforced expression of tlr4 and md-2 rendered responsive ... | 2002 | 12349952 |
| protective effects of antioxidative serotonin derivatives isolated from safflower against postischemic myocardial dysfunction. | n-(p-coumaroyl)serotonin (c) and n-feruroylserotonin (f) with antioxidative activity are present in safflower oil. the protective effects of c and f were investigated in perfused guinea-pig langendorff hearts subjected to ischemia and reperfusion. changes in cellular levels of high phosphorous energy, no and ca2+ in the heart together with simultaneous recordings of left ventricular developed pressure (lvdp) were monitored by an nitric oxide (no) electrode, fluorometry and 31p-nmr. the rate of r ... | 2002 | 12349903 |
| dietary n-3 pufa affect tcr-mediated activation of purified murine t cells and accessory cell function in co-cultures. | diets enriched in n-3 polyunsaturated fatty acids (pufa) suppress several functions of murine splenic t cells by acting directly on the t cells and/or indirectly on accessory cells. in this study, the relative contribution of highly purified populations of the two cell types to the dietary suppression of t cell function was examined. mice were fed diets containing different levels of n-3 pufa; safflower oil (saf; control containing no n-3 pufa), fish oil (fo) at 2% and 4%, or 1% purified docosah ... | 2002 | 12296847 |
| developmental profile of diacylglycerol acyltransferase in maturing seeds of oilseed rape and safflower and microspore-derived cultures of oilseed rape. | diacylglycerol acyltransferase (ec 2.3.1.20) activity was assayed during the maturation of seeds of oilseed rape (brassica napus l.) and safflower (carthamus tinctorius l.). developmental studies were also conducted with microspore-derived embryos of oilseed rape (b. napus l. cv topas) and an embryogenic microspore-derived cell-suspension culture of winter oilseed rape (b. napus l. cv jet neuf). in the maturing seeds, diacylglycerol acyltransferase activity increased to a maximum during rapid ac ... | 1993 | 12231845 |
| cholinephosphotransferase and diacylglycerol acyltransferase (substrate specificities at a key branch point in seed lipid metabolism). | many oilseed plants accumulate triacylglycerols that contain unusual fatty acyl structures rather than the common 16- and 18-carbon fatty acids found in membrane lipids of these plants. in vitro experiments demonstrate that triacylglycerols are synthesized via diacylglycerols in microsomal preparations and that this same sub-cellular fraction is the site for the synthesis of phosphatidylcholine, which in seeds is synthesized from diacylglycerol by cdp-choline: diacylglycerol cholinephosphotransf ... | 1996 | 12226231 |
| effects of dietary eritadenine on delta6-desaturase activity and fatty acid profiles of several lipids in rats fed different fats. | effects of dietary eritadenine on liver microsomal delta6-desaturase activity and the fatty acid profile of phosphatidylcholine, cholesteryl esters, and triglycerides of liver microsomes or plasma were investigated in rats fed different fats (palm oil, olive oil, and safflower oil). the activity of delta6-desaturase was influenced by both dietary fat types and eritadenine. in rats fed control diets, delta6-desaturase activity was higher in the order of the palm oil, olive oil, and safflower oil ... | 2002 | 12224653 |