Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| dietary protein level and the turnover rate of tissue proteins in rats. | 1963 | 14101006 | |
| the metabolism of mucopolysaccharides. i. adrenal steroids and the synthesis of glucosamine-6-phosphate. | 1963 | 14083978 | |
| influence of estradiol-17-beta, progesterone and hydrocortisone on 3-methylcholanthrene-induced mammary cancer in intact and ovariectomized sprague-dawley rats. | 1963 | 14068828 | |
| effects of testosterone, sesame oil, and castration on tissue respiration of male rats exposed to cold. | 1957 | 13453456 | |
| protective effects of sesamin and sesamolin on hypoxic neuronal and pc12 cells. | reactive oxygen species (ros) are important mediators of a variety of pathological processes, including inflammation and ischemic injury. the neuroprotective effects of sesame antioxidants, sesamin and sesamolin, against hypoxia or h2o2-induced cell injury were evaluated by cell viability or lactate dehydrogenase (ldh) activity. sesamin and sesamolin reduced ldh release of pc12 cells under hypoxia or h2o2-stress in a dose-dependent manner. dichlorofluorescein (dcf)-sensitive ros production was i ... | 2003 | 13130514 |
| oral testosterone-triglyceride conjugate in rabbits: single-dose pharmacokinetics and comparison with oral testosterone undecanoate. | development of a safe and effective oral form of testosterone has been inhibited by the rapid hepatic metabolism of nonalkylated androgens. since triglycerides are absorbed via lymphatics and bypass the liver, we hypothesized that a testosterone-triglyceride conjugate (ttc) might allow for safe and effective oral testosterone therapy. therefore, we studied the single-dose pharmacokinetics of oral administration of ttc in rabbits. female new zealand rabbits were administered 2, 4, or 8 mg/kg of t ... | 2003 | 12954663 |
| classification of edible oils by employing 31p and 1h nmr spectroscopy in combination with multivariate statistical analysis. a proposal for the detection of seed oil adulteration in virgin olive oils. | a combination of (1)h nmr and (31)p nmr spectroscopy and multivariate statistical analysis was used to classify 192 samples from 13 types of vegetable oils, namely, hazelnut, sunflower, corn, soybean, sesame, walnut, rapeseed, almond, palm, groundnut, safflower, coconut, and virgin olive oils from various regions of greece. 1,2-diglycerides, 1,3-diglycerides, the ratio of 1,2-diglycerides to total diglycerides, acidity, iodine value, and fatty acid composition determined upon analysis of the res ... | 2003 | 12952424 |
| delayed implantation induced by fadrozole hydrochloride in rats. | the effect of aromatase inhibitors on the implantation process is not well known. this study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (fad). continuous subcutaneous infusion of fad at 300 microg/day from day 1 (the day of sperm detection) through day 7 of pregnancy using a mini-osmotic pump was found to delay the initiation of implantation by 1 or 2 days with no negative effects on embryonic viability. ... | 2003 | 12878290 |
| the effect of ovariectomy and estradiol replacement on collagen and elastic fibers in the bladder of rats. | the authors quantified the collagen and elastic fibers in the bladder wall of ovariectomized rats with and without estradiol replacement. this study was conducted on 60 3-month-old wistar rats. group 1 remained intact; group 2 underwent bilateral ovariectomy and were sacrificed after 30 days; group 3 were sham operated and sacrificed after 30 days; group 4 had a bilateral ovariectomy and after 30 days were started on subcutaneous injections of 17beta-estradiol (10 microg/kg body weight) for 90 d ... | 2003 | 12851753 |
| timing of oral glutamine on dmba-induced tumorigenesis. | a single dose of oral 7,12-dimethylbenz(a)anthracene (dmba) in pubertal rats causes breast tumors by 11 weeks and is associated with ablation of the normal gut glutathione (gsh) production for up to 4 weeks. we hypothesized that glutamine (gln), known to restore the gut gsh production inhibited by dmba, given only during this 4-week period, would prevent breast cancer initiation. | 2003 | 12842461 |
| immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus. | very little is known about the impact of selective estrogen receptor modulators (serms) on the brain. we examined the effects of tamoxifen (tamox) and the synthetic estrogen 17alpha-ethynylestradiol (ee) on estrogen-dependent gene expression and receptor binding in the female rat brain. both immediate and residual effects were examined in both the presence and absence of 17beta-estradiol. two groups of adult, ovariectomized, female rats (n=30 per group) were injected with tamox (5 mg/kg), ee (0. ... | 2003 | 12834913 |
| decontamination of seeds for seed sprout production by high hydrostatic pressure. | garden cress, sesame, radish, and mustard seeds immersed in water were treated with high pressure (250, 300, 350, and 400 mpa) for 15 min at 20 degrees c. after treatment, percentages of seeds germinating on water agar were recorded for up to 11 days. of the seeds tested, radish seeds were found to be the most pressure sensitive, with seeds treated at 250 mpa reaching 100% germination 9 days later than untreated control seeds did. garden cress seeds, on the other hand, were the most pressure res ... | 2003 | 12800989 |
| central administration of the neurotensin receptor antagonist sr48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. | tardive dyskinesia is a movement disorder that develops in 20-30% of patients treated with chronic neuroleptics. whilst the pathogenesis of tardive dyskinesia remains unclear, altered expression of neuropeptides in the basal ganglia has been implicated in its emergence. the peptide neurotensin is expressed in both dopamine d1 receptor-bearing neurons of the direct striatonigral pathway and dopamine d2 receptor-bearing neurons of the indirect striatopallidal pathway. increased levels of striatal ... | 2003 | 12770567 |
| distribution of zoosporic fungi in the mud of major egyptian lakes. | twenty-six identified and three unidentified species belonging to eight genera of zoosporic fungi were recovered from seventy-six mud samples of egyptian lakes using sesame seeds as baits. nineteen samples were collected along the borders of four major lakes. pythium, phytophthora and allomyces, yielded the highest spectra of zoosporic species, while aqualinderella, blastocladia and dictyuchus, had one species. pythium, aphanomyces, allomyces, aqualinderella, phytophthora and saprolegnia were th ... | 2003 | 12761768 |
| methoxychlor modifies the ultradian secretory pattern of prolactin and affects its trh response. | methoxychlor (mtx) is an insecticide characterized by both estrogenic and antiandrogenic properties that may modify the secretory pattern of prolactin. the objective of the present work was to analyze mtx's effects on changes in the episodic secretion of prolactin induced by thyrotropin-releasing hormone (trh). | 2003 | 12761465 |
| chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats. | corticosterone (cort), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion ca3. we tested the hypothesis that cort would impair spatial memory, a hippocampal function. in each of the three experiments, rats received daily, subcutaneous injections of either cort (26.8 mg/kg body weight in sesame oil) or sesame oil vehicle alone (veh). cort given for 21 or 56 days effectively attenuated body weight gain and reduced selective organ and muscle weights. all b ... | 2003 | 12737930 |
| [cycling and balance of copper in farmland ecosystem of jianghan plain in hubei province]. | the cycling and balance of copper in 8 cropping systems, i.e., wheat-rice, rice-rice, rape-soybean, rape-peanut, wheat-sesame, wheat-cotton, pepper-cabbage and radish-eggplant in jianghan plain of hubei province were studied. the results showed that the main output of copper was crop harvesting, up to 85.9%-95.1% of total output, and the output of copper by field runoff and soil leaching was low. the main inputs of copper were organic fertilizer, rainfall, falldrop, and natural return. the input ... | 2003 | 12722442 |
| temporal association of ca(2+)-dependent protein kinase with oil bodies during seed development in santalum album l.: its biochemical characterization and significance. | calcium-dependent protein kinase (cdpk) is expressed in sandalwood (santalum album l.) seeds under developmental regulation, and it is localized with spherical storage organelles in the endosperm [anil et al. (2000) plant physiol. 122: 1035]. this study identifies these storage organelles as oil bodies. a 55 kda protein associated with isolated oil bodies, showed ca(2+)-dependent autophosphorylation and also cross-reacted with anti-soybean cdpk. the cdpk activity detected in the oil body-protein ... | 2003 | 12721377 |
| oilcakes as protein sources in supplementary diets for the growth of cirrhinus mrigala (ham.) fingerlings: laboratory and field studies. | five isonitrogenous diets (1-5) with 40% protein using oilcakes as protein sources were formulated and fed to cirrhinus mrigala fingerlings maintained both under laboratory and field conditions. water soaking of oilcakes for 24 h before incorporation in the diets helped in the reduction of antinutrient factors (phytase and tannins). live weight gain in fish fingerlings fed on a diet containing groundnut oilcake (gnoc) was significantly (p < 0.05) enhanced in comparison to the other dietary treat ... | 2003 | 12688472 |
| estradiol alters afterdischarge threshold and acquisition of amygdala kindled seizures in male rats. | we have previously shown that estradiol (e(2)) can initially increase and then decrease kindle seizure parameters in amygdala kindled male rats. this study focuses on the effects of estradiol benzoate (eb) on afterdischarge (ad) threshold and electrical kindling acquisition in intact male rats. after implantation of tripolar and monopolar electrodes in amygdala and dura surface respectively, effects of eb on ad threshold and electrical kindling acquisition were investigated by daily injection of ... | 2003 | 12648754 |
| increase of viability of entrapped cells of lactobacillus delbrueckii ssp. bulgaricus in artificial sesame oil emulsions. | a technique was developed to protect lactic acid bacteria (lactobacillus delbrueckii ssp. bulgaricus) against simulated gastrointestinal conditions by encapsulation of bacterial cells within artificial sesame oil emulsions. purified sesame oil bodies consisting of approximately 99% oil, 0.5% phospholipid, and 0.5% protein were decomposed by heating at 70 degrees c for 1 h. the bacteria cultured in nonfat milk were encapsulated in artificial oil emulsions constituted with decomposed sesame oil bo ... | 2003 | 12647948 |
| estradiol valerate and alcohol intake: a comparison between wistar and lewis rats and the putative role of endorphins. | studies show that estrogens can influence alcohol consumption; however, findings are variable and an etiology remains unknown. furthermore, estrogen administration can alter several neurotransmitter systems implicated in alcohol consumption, including the beta-endorphin (beta-ep) system. the present studies investigate (a) whether estradiol valerate (ev) alters voluntary alcohol consumption in wistar and lewis rats, (b) if an effect of ev on drinking is associated with changes in hypothalamic or ... | 2003 | 12642176 |
| changes in telomerase activity in experimentally induced atretic follicles of immature rats. | follicular atresia is characterized by apoptosis of granulosa cells, and telomerase plays an important role in the apoptotic process. to study the relationship between follicular atresia and telomerase activity, we investigated changes in telomerase activity and localization in experimentally induced atretic follicles of immature rats. immature female sprague-dawley rats received 15 iu equine cg (ecg) by subcutaneous injection. rats were killed under ether anesthesia at 2, 3, 4, or 5 days after ... | 2002 | 12625407 |
| isolation and characterization of a myo-inositol 1-phosphate synthase cdna from developing sesame (sesamum indicum l.) seeds: functional and differential expression, and salt-induced transcription during germination. | a cdna (semips1) encoding myo-inositol 1-phosphate synthase (ec 5.5.1.4) (mips) has been characterized from sesame (sesamum indicum l. cv. dan-baek) seeds and its functional expression analyzed. the semips1 protein was highly homologous with those from other plant species (88-94%), while a much lower degree of sequence homology (53-62%) was found with other organisms such as humans, mouse, algae, yeast, drosophila, bacteria and other prokaryotes. a yeast-based complementation assay in yeast muta ... | 2003 | 12624775 |
| novel antioxidative metabolites in rat liver with ingested sesamin. | sesamin, a major lignan in sesame oil, is known to have many biological activities, especially protective effects against oxidative damage in the liver. as sesamin itself has no antioxidative properties in vitro, to elucidate the mechanism of its antioxidative effects, the reaction products of sesamin in rat liver homogenate were analyzed. the methylenedioxyphenyl moiety in the structure of sesamin was shown to be changed into a dihydrophenyl (catechol) moiety. the enzymatic reaction products in ... | 2003 | 12617602 |
| effect of pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone. | pretreatment with oral tadenan (tad) has been shown to possess a protective effect on bladder dysfunction-induced obstruction. we evaluated the functional influence of cotreatment and post-treatment with oral tad on the frequency/volume characteristics of micturition of conscious rats stimulated with exogenous dihydrotestosterone (dht) to induce experimental prostate growth. | 2003 | 12597984 |
| role of ovarian progesterone and potential role of prostaglandin f2alpha and prostaglandin e2 in modulating the uterine response to infectious bacteria in postpartum ewes. | in sheep and cattle, the postpartum uterus is resistant to bacterial challenge until after corpora lutea develop. a 2 x 2 factorial arrangement of treatments was used to determine whether prostaglandins may mediate the effects of progesterone in transforming the postpartum uterus from resistant to susceptible. on d 14 postpartum, ewes (n = 6/group) were ovariectomized or sham ovariectomized, and the vena cava was catheterized for daily collection of uteroovarian-enriched blood. from d 15 to 20, ... | 2003 | 12597400 |
| the analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine pivalate, in rats. | nalbuphine is an opioid-analgesic with agonist-antagonist properties. recently, we have synthesized a nalbuphine prodrug, nalbuphine pivalate. the aim of the present study was to evaluate the analgesic effect and the analgesic duration of this prodrug. | 2002 | 12596618 |
| simple physical treatment as an effective tool to improve the functional properties of rapeseed (brassica campestris var. toria) and sesame seed (sesamum indicum) meals. | dry and 24-h imbibed rapeseeds and sesame seeds were defatted with hexane, and freeze-dried powder was analysed for the functional properties of the meals. the water absorption capacity of the imbibed rapeseed meal and the fat absorption capacity of both the imbibed meals were higher than dry meals. protein solubility of the rapeseed meal was improved by imbibition and both the imbibed meals exhibited maximum protein solubility at ph 12. the rapeseed meal possessed better foaming properties and ... | 2002 | 12590740 |
| estrogen modulation of nmda-induced seizures in ovariectomized and non-ovariectomized rats. | the objective of this study was to examine the neuroprotective effects of estrogen in response to n-methyl-d-aspartate (nmda)-induced seizures in both male and female rats. thirty-eight long-evans rats were divided into five groups: ovariectomized females, non-ovariectomized females, ovariectomized females with estrogen replacement (10 microg 17beta-estradiol in 100 microl sesame oil), males given exogenous estrogen and males receiving no estrogen. using stereotaxic surgery, a cannula was placed ... | 2003 | 12576185 |
| overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate. | this study's purpose was to examine whether functional overload with nandrolone decanoate (nd) administration increased muscle mass and steroid receptor concentration in aged rat soleus (sol) and plantaris (plan) muscle. nd (6 mg/kg body wt) was administered once a week for 4 wk, whereas control rats received sesame seed oil injections. functional overload of the hindlimb sol and plan was induced by synergistic gastrocnemius muscle ablation at the beginning of the fourth week. adult (5 mo of age ... | 2003 | 12571141 |
| edible oil crops and their integration with the major cereals in north shewa and south welo, central highlands of ethiopia: an ethnobotanical perspective. | a total of 1050 sorghum (sorghum bicolor) and tef (eragrostis tef) fields distributed in six study sites within north shewa and south welo (central highlands of ethiopia) were systematically surveyed to examine the status of integration of edible oil crops into the cereal-based farming system. farmers' criteria for, and perception on, integration between edible oil crops and the major cereals at field level as well as integration between the cereal grains and the oilseeds in food making at home ... | 2002 | 12564630 |
| ntp studies of magnetic field promotion (dmba initiation) in female sprague-dawley rats (whole-body exposure/gavage studies). | electric and magnetic fields are associated with the production, transmission, and use of electricity; thus, the potential for human exposure is high. these elec-tric and magnetic fields are predominantly of low fre-quency (60 hz in the united states and 50 hz in europe) and generally of low intensity. because some epidemiology studies and initiation/promotion studies in rats have suggested a potential for increased breast cancer rates with increasing magnetic field exposure, the ability of 50- ... | 1999 | 12563342 |
| effect of excessive intake of thermally oxidized sesame oil on lipids, lipid peroxidation and antioxidants' status in rats. | fresh and thermally oxidized sesame, groundnut and coconut oils were fed to different groups of rats, as high fat diet (20%). feeding fresh and thermally oxidized oils increased the levels of total cholesterol, low density lipoprotein cholesterol (ldl-c), and phospholipids but high density lipoprotein cholesterol (hdl-c) decreased in all the experimental animals. the levels of very low density lipoproteincholesterol (vldl-c) and triacylglycerol increased only in groundnut and coconut oils-fed gr ... | 2000 | 12557909 |
| passive transfer of nut allergy after liver transplantation. | an anaphylactic reaction to cashew nut developed in a nonatopic 60-year-old man 25 days after receiving a liver allograft from a 15-year-old atopic boy who died of anaphylaxis after peanut ingestion. the liver recipient had no history of nut allergy. posttransplantation skin prick test results were positive for peanut, cashew nut, and sesame seed, and the donor had allergen-specific ige antibodies to the same 3 allergens. contact tracing of the recipients of other solid organs from the same dono ... | 2003 | 12546616 |
| hypothalamic indolamines during embryonic development and effects of steroid exposure. | the serotonin system has been implicated in the modulation of endocrine and behavioral components of reproduction. in this study, we examined endogenous hypothalamic indolamines during sexual differentiation and long-term effects of exogenous steroids during this time. in experiment 1, japanese quail were studied during the last half of embryonic development and early post-hatch. samples were taken at embryonic day 10 (e10), e12, e14, e16, hatch (day 0), and days 3 and 5, post-hatch. hypothalami ... | 2003 | 12535620 |
| bisphenol a increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. | recently, we reported that bisphenol a (bpa), an endocrine disrupter, increased progesterone receptor (pr) mrna in the preoptic area (poa) in adult ovariectomized rats. in the present study, we examined whether bpa also induced expression of pr proteins in both the poa and the ventromedial hypothalamic nucleus (vmh), and whether those proteins were involved in the induction of sexual behaviour. two weeks after ovariectomy, rats received a subcutaneous (s.c.) injection of bpa, 17 beta-oestradiol ... | 2003 | 12535155 |
| preimplantation mouse embryo development as a target of the pesticide methoxychlor. | effects of methoxychlor (mxc) and estradiol-17beta (e) were studied in mouse preimplantation embryos. pregnant mice received s.c. injections of sesame oil only, 10 microg e, or 0.5 mg purified (95%) mxc on days 2-4 of pregnancy (plug = day 1). another group received a single dose of 2.5 microg e on day 2 only. based on the average weight of pregnant females, 10 microg of estradiol was equivalent to 0.33 mg/kg of bw, 2.5 microg of estradiol was equivalent to 0.082 mg/kg of bw, and the 0.5-mg dose ... | 2003 | 12507662 |
| bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. | the industrial chemical, 4-vinylcyclohexene diepoxide (vcd), kills oocytes within immature follicles in the ovaries of mice and rats and is considered a potential occupational health hazard. it has been reported that vcd-induced follicle loss occurs via a cell death process involving elevated expression of bax, a proapoptotic bcl-2 family member, and increased caspase-3-like activity. we have previously shown that oocytes lacking acid sphingomyelinase (asmase; an enzyme that generates the proapo ... | 2003 | 12488331 |
| posttraining androgens' enhancement of cognitive performance is temporally distinct from androgens' increases in affective behavior. | steroid hormone-induced variations in spatial learning and memory tasks have been reported. in this study, androgens' effects in various cognitive and affective tasks were investigated in order to determine whether any observed differences in cognitive performance could be due to affective changes produced by the hormones. ovariectomized rats (n = 72) received 0.0, 3.0, or 7.5 mg/kg subcutaneously, of testosterone (t), dihydrotestosterone (dht), or 5 alpha-androstane-3 alpha,17 beta-diol (3 alph ... | 2001 | 12467112 |
| high levels of estradiol impair spatial performance in the morris water maze and increase 'depressive-like' behaviors in the female meadow vole. | the present study investigated sex differences and the effect of a high level of estradiol in the female meadow vole on performance in the forced swim test (fst) and the morris water maze in meadow voles. female meadow voles were ovariectomized (ovx) and administered either vehicle (sesame oil) or estradiol for 2 days prior to performing the fst. four days following the fst, all animals were run in the morris water maze. results indicated that estradiol-injected female meadow voles showed more ' ... | 2002 | 12419397 |
| preparation and characterization of papain-modified sesame (sesamum indicum l.) protein isolates. | defatted sesame meal ( approximately 40-50% protein content) is very important as a protein source for human consumption due to the presence of sulfur-containing amino acids, mainly methionine. sesame protein isolate (spi) is produced from dehulled, defatted sesame meal and used as a starting material to produce protein hydrolysate by papain. protein solubility at different ph values, emulsifying properties in terms of emulsion activity index (eai) and emulsion stability index (esi), foaming pro ... | 2002 | 12405787 |
| microbial retention characteristics of sterilizing-grade membrane filters with alginate substituted for oil-based products. | for oil-based products, fda recommends substitution of the oil with a compound which has similar viscosity and physical characteristics. in this study, a substitute for oil-based products was screened by measuring the viscosity and filterability, and examined for the presence of cell clumps in the various test fluids using an optical microscopy. the viscosity of the test fluids measured in the range of about 60-75 cp. brevundimonas diminuta (formerly pseudomonas diminuta), a standard challenge t ... | 2002 | 12404720 |
| healing action of nerve growth factor on lameness in adult goats. | we investigated the effect of nerve growth factor in goats affected by lameness, a condition that is associated with cutaneous ulcers, abscesses and granulomas. lesions were treated daily with 1 microgram of nerve growth factor (ngf), dissolved in 100 microliters of sesame oil or with sesame oil only. healthy controls were treated with sesame oil only for periods ranging from two to four weeks and behavioral, biochemical and histopathological conditions were evaluated. topical application of ngf ... | 2002 | 12387143 |
| repeated anabolic-androgenic steroid treatment during adolescence increases vasopressin v(1a) receptor binding in syrian hamsters: correlation with offensive aggression. | repeated anabolic-androgenic steroid treatment during adolescence increases hypothalamic vasopressin and facilitates offensive aggression in male syrian hamsters (mesocricetus auratus). the current study investigated whether anabolic-androgenic steroid exposure during this developmental period influenced vasopressin v(1a) receptor binding activity in the hypothalamus and several other brain areas implicated in aggressive behavior in hamsters. to test this, adolescent male hamsters were administe ... | 2002 | 12367571 |
| the effect of hypophysectomy on 9,10-dimethyl-1,2-benzanthracene-induced carcinogenesis [abstract]. | in view of the findings of moon, simpson, and evans (science, 116:331,1952) that the hypophysectomized rat was refractory to the carcinogenic effect of methyl-cholanthrene, similar experiments have been conducted but using the more powerful carcinogen 9,10-dimethyl-1,2-benzanthracene. the results of 2 separate experiments were as follows: all animals received 5 mg in sesame oil of the carcinogen intramuscularly. in the control animals, 15 showed discrete sarcoma out of 21 animals in 4-5 month ... | 1954 | 12338146 |
| changes in structure and function of the preputial glands following daily injections of estrone or testosterone propionate in ovariectomized, "normal" and neonatally estrogenized rats. | these experiments were undertaken to determine if there is any difference in response of the preputial glands to estrogen or androgen between neonatally estrogenized adult female rats when ovariectomized and normal female rats similarly ovariectomized. 23 sprague-dawley females were given daily injections of estrone for 20 days from day of birth. doses were 50 mcg in .2 ml sesame oil for the first 10 days and 100 mcg in .04 ml of oil for the next 10 days. these are referred to as estrogenize ... | 1970 | 12304872 |
| cyclosporine attenuates the autonomic modulation of reflex chronotropic responses in conscious rats. | cyclosporine a (cya), an immunosuppressant drug, has been shown to attenuate the baroreflex control of heart rate (hr). this study investigated whether or not the cya-induced baroreflex dysfunction is due to alterations in the autonomic (sympathetic and parasympathetic) control of the heart. we evaluated the effect of muscarinic or beta-adrenergic blockade by atropine and propranolol, respectively, on reflex hr responses in conscious rats treated with cya (20 mg x kg(-1) x day(-1) dissolved in s ... | 2002 | 12269786 |
| histological study on norethynodrel treated rat ovary. | in an attempt to disclose the antiovulatory mechanism of norethynodrel, a progestational compound having slight estrogenic action, a histological study of treated rat ovaries was made. 4 test animals were injected daily for 14 days with 1 mg of norethynodrel in .3 ml sesame oil. all were killed 24 hr after the last injection. ovaries of treated rats showed follicular degeneration (cystic atresia), interstitial cell degeneration, and cellular hypertrophy of lutein cells. immature follicles di ... | 1968 | 12254411 |
| studies on some feed additives giving partial protection against ochratoxin a toxicity in chicks. | significant protective effects of the feed additives: water extract of artichoke, sesame seed, roxazyme-g and l-beta phenylalanine against the growth inhibitory effect of ochratoxin a (ota) and associated pathomorphological changes were seen. similarly, there was less ota-induced decrease in serum total protein and increase of serum creatinine and urea in the chicks. whereas ota induced strong degenerative changes and an increase in weight of kidneys and liver as well as a decrease of the weight ... | 2002 | 12243862 |
| uterine-ovarian biochemical and developmental interactions to the postimplantation treatment with a butadiene metabolite, diepoxybutane, in pregnant rats. | an industrial chemical used in synthetic rubber production, 1,3-butadiene, is toxic to reproduction in rats and mice. bioactivation of butadiene to reactive intermediates, i.e. diepoxybutane and other metabolites, is responsible for this toxicity. the present study examines the biochemical and developmental mechanisms of diepoxybutane at the feto-maternal placental axis during gestation. female sprague-dawley rats were administered four daily intraperitoneal doses of diepoxybutane in groups (0.2 ... | 2002 | 12242682 |
| lipids, proteins, and structure of seed oil bodies from diverse species. | oil bodies isolated from the mature seeds of rape (brassica napus l.), mustard (brassica juncea l.), cotton (gossypium hirsutum l.), flax (linus usitatis simum), maize (zea mays l.), peanut (arachis hypogaea l.), and sesame (sesamum indicum l.) had average diameters that were different but within a narrow range (0.6-2.0 [mu]m), as measured from electron micrographs of serial sections. their contents of triacylglycerols (tag), phospholipids, and proteins (oleosins) were correlated with their size ... | 1993 | 12231682 |
| antihypertensive effect of sesamin. iv. inhibition of vascular superoxide production by sesamin. | we previously demonstrated the preventive effect of sesamin, a lignan from sesame oil, on the development of several experimental models of hypertension. in the present study, we explored the mechanisms underlying the antihypertensive effect of sesamin using the deoxycorticosterone acetate (doca)-salt rat hypertensive model. after a 5-week treatment period, aortic superoxide (o2-) production was measured in the lucigenin chemiluminescence assay. chemiluminescence signals significantly decreased ... | 2002 | 12230131 |
| progesterone inhibits rejection of xenogeneic transplants in the sheep uterus. | one of the proposed roles of progesterone is to prevent maternal immunological destruction of the allogeneic conceptus. here, it was demonstrated that progesterone allows survival of a xenotransplant placed in the uterine lumen. | 2002 | 12218378 |
| neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents. | the neurotoxicity of beta-arteether (ae) is related to drug accumulation in blood due to slow and prolonged absorption from the intramuscular injection sites. in this efficacy and toxicity study of ae, the traditional sesame oil vehicle was replaced with cremophore to decrease the accumulation and toxicity of ae. dihydroartemisinin (dqhs), a more toxic and active metabolite of ae, was also analyzed. when administered at a daily dosage of 25 mg/kg for seven days, blood accumulation of ae with ses ... | 2002 | 12201585 |
| sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats. | to investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats. | 2002 | 12163806 |
| chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the epstein-barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. | resveratrol, sesamol, sesame oil and sunflower oil are known natural dietary components with intrinsic cancer chemopreventive potentials. as a part of our study of dietary constituents as potential cancer chemopreventive agents, we have assessed the anti-cancer potentials of these products in the promotion stage of cancer development employing the in vitro epstein-barr virus early antigen activation assay induced by the tumor promoter 12-o-tetradecanoylphorbol 13-acetate (tpa). further, we studi ... | 2002 | 12162952 |
| methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. | methoxychlor (mxc) is currently used to protect agricultural products from insects. previous studies show that mxc adversely affects the ovary, but the target cells were not revealed by those studies. therefore, the purpose of this study was to test the hypothesis that mxc induces ovarian changes by adversely affecting the antral follicles and the ovarian surface epithelium in the mouse. to test this hypothesis, cycling female cd-1 mice (39 days) were dosed with mxc (8, 16, or 32 mg/kg/day), kep ... | 2002 | 12151644 |
| serotonin modulates offensive attack in adolescent anabolic steroid-treated hamsters. | chronic anabolic-androgenic steroid (aas) treatment during adolescence facilitates offensive aggression in male syrian hamsters (mesocricetus auratus). the current study assessed whether adolescent aas-facilitated offensive attack was modulated by serotonin (5-ht) and if aas exposure during this developmental period influenced 5-ht innervation to areas of hamster brain implicated in aggressive behavior. in a first experiment, hamsters were administered high-dose aas throughout adolescence, and t ... | 2002 | 12151048 |
| influence of testosterone on autotomy in castrated male rats. | sex-related differences exist in nociception and gonadal steroids influence the analgesic response in animals and humans. as we have shown previously, estrogen could modify autotomy in female rats using the sciatic nerve transection model. to further characterize the relationship between gonadal steroid and nociception, the role of testosterone on autotomy in sciatic nerve sectioned rats was investigated. twenty male rats were subjected to orchiectomy (orx). then ten rats received subcutaneous s ... | 2002 | 12150198 |
| identification of sesame seed allergens by 2-dimensional proteomics and edman sequencing: seed storage proteins as common food allergens. | sesame seed allergy is becoming increasingly prevalent, probably because of its use in international fast-food and bakery products. despite this fact, few studies have focused on the identification of its major allergenic proteins. | 2002 | 12110835 |
| long-term effects of the mammary carcinogen 7,12-dimethylbenz(a) anthracene on hypothalamic gonadotropin-releasing hormone and its pituitary receptor gene expression, during the promotion stage, in female sprague-dawley rats. | a single intragastric administration of 7,12-dimethylbenz(a)anthracene (dmba) has been shown to induce mammary tumors in young cycling female sprague-dawley rats. the appearance of these tumors is preceded by a series of neuroendocrine disturbances, including attenuation of the preovulatory luteinizing hormone (lh) surge and amplification of the preovulatory 17beta-estradiol surge, and gonadotropin-releasing hormone (gnrh) released in vitro. in this study, we examined the hypothesis that dmba ad ... | 2002 | 12083628 |
| corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis. | prenatal stress strongly affects sexual dimorphism of male rats. much less information is instead available on the effects of postnatal stress on sexual maturation during the so-called stress hyporesponsive period (shrp). for this reason, we compared corticosterone-treated (cs; 10 mg/kg sc, suspended in sesame oil) or maternally separated pups (ms; 5 h/day in the first week of life) with control rats. control and ms pups also received sesame oil injections. the effects of these procedures on phy ... | 2002 | 12076728 |
| gibberellin and auxin-indole production by plant root-fungi and their biosynthesis under salinity-calcium interaction. | rhizosphere and rhizoplane of fababean (vicia faba), melochia (corchorus olitorius), sesame (sesamum indicum) and soyabean (glycine max) plants are inhabited with fungi, mostly aspergillus flavus, a. niger, fusarium oxysporum, penicillium corylophilum, p. cyclopium, p. funiculosum and rhizopus stolonifer. all fungal species have the ability to produce gibberellin (ga) but f. oxysporum was found to produce both ga and indole-acetic acid (iaa). the optimum period for ga and iaa production by f. ox ... | 2002 | 12073817 |
| in vivo investigation of progressive alterations in rat mammary gland tumors by near-infrared spectroscopy. | we have investigated mammary gland tissues of female rats treated with 7,12-dimethylbenz[a]anthracene in sesame oil by a near infrared (nir) spectroscopy finding that the dna and water contents in the cancerous tissues were larger than those in the normal tissues but that the lipid content in the former was less than that in the latter. with protein contents, however, little difference was observed between the two. thus, we used a lipid band around 1725 nm (the first overtone of n-alkane) and a ... | 2002 | 12054444 |
| butyl benzyl phthalate, an endocrine disrupter, inhibits pulsatile luteinizing hormone secretion under an insulin-induced hypoglycaemic state in ovariectomized rats. | butyl benzyl phthalate (bbp) and bisphenol a (bpa), termed endocrine disrupters, are known to mimic oestrogen in their actions, and therefore there is concern about their effect on reproductive functions. since it is reported that the inhibitory action of oestrogen on the pulsatile secretion of luteinizing hormone (lh) is enhanced under insulin-induced hypoglycaemia, whether this also applies to bbp and bpa was examined in the present study. in adult ovariectomized (ovx) rats, the pulsatile lh s ... | 2002 | 12047723 |
| comparative study of three different methods for the determination of aflatoxins in tahini. | aflatoxins spiked at three different levels (6.5, 13.0, and 19.5 microg/kg) in tahini, a sesame butter, were analyzed by using three different methods: high-performance liquid chromatography (hplc), fluorometry, and enzyme-linked immunosorbent assay (elisa). an immunoaffinity column was used for cleanup and purification of extracts prior to detection by hplc and fluorometry. all methods were statistically evaluated for accuracy, precision, and simple correlations. additionally, 14 tahini samples ... | 2002 | 12033798 |
| evidence for [1,5] sigmatropic rearrangements of cla in heated oils. | linoleic acid was heated at 200 degrees c under helium. analysis of degradation products by gc on a long polar open tubular capillary column showed the presence of cla isomers. the identified mono trans cla isomers were cis-9,trans-11, trans-9,cis-11, trans-10,cis-12, cis-10,trans-1 2, trans-8,cis-10, and cis-11,trans-13 18:2 acids. oils containing different levels of linoleic acid (peanut, sesame seed, and safflower seed oils) were also heat treated, resulting in similar cla distributions. elut ... | 2002 | 12030325 |
| effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin e concentrate rich in tocotrienols. | we have shown that sesame lignans added to rat diet resulted in significantly greater plasma and tissue concentrations of alpha- and gamma-tocopherol concentrations in supplemented rats than in rats without supplementation. in the present studies we examined whether sesaminol, a sesame lignan, enhances tocotrienol concentrations in plasma and tissues of rats fed diets containing a tocotrienol-rich fraction of palm oil (t-mix). in experiment 1, effects of sesaminol on tocotrienol concentrations i ... | 2002 | 12030315 |
| developmental exposure to polychlorinated biphenyls affects sexual behavior of rats. | polychlorinated biphenyls (pcbs) are persistent environmental contaminants that have the potential to disrupt reproduction through a variety of different pathways. in the present study, we investigated the effects of fetal and lactational pcb exposure on reproductive behavior in male and female laboratory rats. these pregnant rats were injected daily with either 2,4,2',4'-tetrachlorobiphenyl (pcb 47) at the dosage of 1 or 20 mg/kg body weight or 3,4,3',4'-tetrachlorobiphenyl (pcb 77) at the dosa ... | 2002 | 12020734 |
| comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. | sesamin is one of the most abundant lignans in sesame seed. episesamin, a geometrical isomer of sesamin, is not a naturally occurring compound and is formed during the refining process of non-roasted sesame seed oil. we compared the physiological activities of these compounds in affecting hepatic fatty acid metabolism in rat liver. rats were fed either a control diet free of lignan or diets containing 0.2% of sesamin or episesamin for 15 days. these lignans increased the mitochondrial and peroxi ... | 2002 | 12015159 |
| dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. | we showed previously that dietary sesame seed and its lignans elevate the tocopherol concentration in rats. to clarify their effect on tocopherol metabolism, we determined in this study the urinary excretion of 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (gamma-cehc), a gamma-tocopherol metabolite, in rats fed sesame seed or its lignans. rats were fed diets with or without sesame seed for 28 d in experiment 1, and for 1, 3 and 7 d in experiment 2. on d 28, dietary sesame seed elevated (p ... | 2002 | 11983822 |
| [testosterone induction of metallothionein in accessory genital organs of male domestic cats]. | orchidectomy of cats resulted in a decrease of metallothionein (mt) in the dorsolateral and ventral lobes of the prostate and in the urethral gland to 21.2% (p<0.01), 88.4% (p>0.05) and 18.5% (p<0.01) of those of intact domestic cats respectively. mt content in the dorsolateral lobe and urethral gland was not restored in orchidectomized cats injected with sesame oil. after injection of a single subcutaneous dose of 10 microg/kg bw of testosterone (t) for 3 d in succession, the mt contents in the ... | 1999 | 11972185 |
| developmental effects of perinatal exposure to bisphenol-a and diethylstilbestrol on reproductive organs in female mice. | reproductive tract development is influenced by estrogen. the aim of this study was to determine the effects of an environmental estrogenic chemical bisphenol-a (bpa) on prenatal and postnatal development of female mouse reproductive organs. in the prenatal treatment group, bpa or the synthetic estrogen diethylstilbestrol (des) were given by subcutaneous (s.c.) injections to pregnant mice during gestational days 10-18. some offspring treated prenatally with 10 and 100 mg/kg bw bpa or 0.67 and 67 ... | 2002 | 11955941 |
| steroleosin, a sterol-binding dehydrogenase in seed oil bodies. | besides abundant oleosin, three minor proteins, sop 1, 2, and 3, are present in sesame (sesamum indicum) oil bodies. the gene encoding sop1, named caleosin for its calcium-binding capacity, has recently been cloned. in this study, sop2 gene was obtained by immunoscreening, and it was subsequently confirmed by amino acid partial sequencing and immunological recognition of its overexpressed protein in escherichia coli. immunological cross recognition implies that sop2 exists in seed oil bodies of ... | 2002 | 11950969 |
| simple physical treatment as an effective tool to improve the functional properties or rapeseed (brassica campestris var. toria) and sesame seed (sesamum indicum) meals. | dry and 24 h imbibed rapeseeds and sesame seeds were defatted with hexane and the resulting freeze-dried powder was analysed for the functional properties of the meals. water absorption capacity (wac) of imbibed rapeseed meal and fat absorption capacity (fac) of both the imbeded meals were higher than those for dry meals. protein solubility of rapeseed meals was improved by imbibition and both the imbibed meals exhibited maximum protein solubility at ph 12. rapeseed meal possessed better foaming ... | 2002 | 11939112 |
| suppressive action of orexin a on pulsatile luteinizing hormone secretion is potentiated by a low dose of estrogen in ovariectomized rats. | orexins are hypothalamic neuropeptides which stimulate luteinizing hormone (lh) secretion in estrogen- and progesterone-treated ovariectomized (ovx) rats and suppress it in ovx rats not treated with estrogen, suggesting a modulation by estrogen of the response to orexins. we examined the effects of orexin a on pulsatile lh secretion in ovx rats treated with a very small dose of estrogen so as to maintain the pulsatile secretion of lh. the estrogen treatment was done 24 h before the blood samplin ... | 2002 | 11914586 |
| effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys. | gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. sex differences have also been observed in the antinociceptive effects of opioid agonists. these findings suggest that gonadal hormones may modulate opioid antinociception. | 2002 | 11862360 |
| estrogen's effects on activity, anxiety, and fear in two mouse strains. | estrogen has effects on activity levels and emotional reactivity in both humans and rats. in a recent study conducted in ovariectomized (ovx) c57bl/6 (c57) mice we found that treatment with estradiol benzoate (eb) increased anxiety, fear learning, and running wheel activity relative to vehicle control (veh). the present study was conducted to examine the stability of these findings across mouse strains (c57 and swiss-webster; sw), to get a better sense of the magnitude of the anxiety response by ... | 2002 | 11853861 |
| antithrombotic lipid minor constituents from vegetable oils. comparison between olive oils and others. | many epidemiological studies suggest that vegetable oils and especially olive oil present a protective effect against atherosclerosis. in this study, total lipids (tl) of greek olive oils and seed oils of four kinds, namely, soybean, corn, sunflower, and sesame oil, were separated into total polar lipids (tpl) and total neutral lipids (tnl) via a novel extraction procedure. tpl and tnl of olive oil were fractionated by hplc for further study. each lipid fraction from hplc separation along with t ... | 2002 | 11853496 |
| preparation and stability of agarose microcapsules containing bcg. | an emulsification/internal gelation method of preparing small-sized agarose microcapsules containing bacillus calmette-guerin (bcg) is reported. agarose microcapsules have been prepared by the emulsification of the hydrogel within a vegetable oil followed by its gelation due to the cooling of the system. four different oils (sesame, sweet almonds, camomile and jojoba) were assayed. the rheological analysis of the oils showed a newtonian behaviour, with viscosity values of 37.7, 51.2, 59.3 and 67 ... | 2002 | 11837978 |
| testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-jun nh2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for alzheimer's disease. | we have shown previously that glycogen synthase kinase-3 beta (gsk-3 beta), cyclin-dependent kinase 5, and c-jun nh(2)-terminal kinase become overactivated and hyperphosphorylate tau in heat-shocked female rats. this hyperphosphorylation of tau is estrogen-independent, prevented by androgens, and similar to alzheimer's disease. in this study, ovariectomized (ovx) sprague-dawley rats (n = 75) received daily injections of 10 microg of 17 beta-estradiol benzoate (eb), or 250 microg of testosterone ... | 2002 | 11805297 |
| effects of vitamin e and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. | the preventive effects of sesamin, a lignan from sesame oil, and vitamin e on hypertension and thrombosis were examined using stroke-prone spontaneously hypertensive rats (shrsp). at 5 weeks of age the animals were separated into four groups: (i) a control group; (ii) a vitamin e group, which was given a 1,000 mg alpha-tocopherol/kg diet; (iii) a sesamin group, given a 1,000 mg sesamin/kg diet; and (iv) a vitamin e plus sesamin group, given a 1,000 mg alpha-tocopherol plus 1,000 mg sesamin/kg di ... | 2001 | 11768736 |
| estrogenic regulation of hsp90 kd synthesis in rat urinary bladder. | the role of heat shock protein (hsp90 kd) has been investigated in regard to its association with steroid receptors. hsp90 kd may play a role in steroid receptor stabilization and activation. oophorectomized sprague-dawley rats (n = 25) were placed into five groups and injected subcutaneously with 30 microg beta-estradiol 17-benzoate in sesame oil, with one group injected with carrier oil (control). after estrogen administration, the rats were killed, and their bladders removed for immunostainin ... | 2001 | 11762796 |
| hypoglycemic effect of a hot-water extract from defatted sesame (sesamum indicum l.) seed on the blood glucose level in genetically diabetic kk-ay mice. | genetically diabetic (type ii) kk-ay mice, male and 5 weeks of age, were divided into one group of 12 mice that were fed on a basal (bas) diet and three groups of 6 mice each that were fed on the test diets for 4 weeks. each test diet contained 4.0% of the hot-water extract (hes) from defatted sesame (sesamum indicum l.) seed, 1.4% of the water eluent fraction (wfh) of hes or 0.7% of the methanol eluent fraction (mfh) of hes from a glass column packed with hp-20 resin. at the end of the feeding ... | 2001 | 11758931 |
| sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. | the effect of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid synthesis was examined in rats. rats were fed experimental diets containing varying amounts (0, 0.1 and 0.2% for exp. 1 and 0, 0.2 and 0.4% for exp. 2, respectively) of sesamin for 15 days. the activity and gene expression of enzymes involved in fatty acid synthesis including acetyl-coa carboxylase, fatty acid synthase, atp-citrate lyase and glucose-6-phosphate dehydrogenase decreased as the dietary lev ... | 2001 | 11750882 |
| dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. | chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. for example, both stress and chronic administration of corticosterone produce dendritic atrophy in hippocampal neurons (woolley c, gould e, mcewen bs. 1990. exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. brain res 531:225-231; watanabe y, gould e, mcewen bs, 1992b. stress induces atrophy of apical dendrites of hippocampal ca3 pyramid ... | 2001 | 11745662 |
| comparison of the lymphatic transport of a lipophilic drug from vehicles containing alpha-tocopherol and/or triglycerides in rats. | the applicability of alpha-tocopherol as a lymphotropic carrier for a highly lipophilic drug has been evaluated. transport to the intestinal lymph of the highly lipophilic model drug, lu28-179, in rats after administration to the stomach in an alpha-tocopherol emulsion was compared with lymphatic transport after administration of a sesame oil emulsion and an alpha-tocopherol/sesame oil emulsion. lymphatic transport of the triglycerides and of alpha-tocopherol was determined. a conscious rat mode ... | 2001 | 11732746 |
| effect of short-term calf removal at three stages of a follicular wave on fate of a dominant follicle in postpartum beef cows. | the hypothesis that ovulation in response to short-term (48 h) calf removal (cr) is dependent on the developmental stage of the dominant follicle was tested in two studies. the objective of exp. 1 was to characterize the fate of a dominant follicle following 48-h cr on d 2, 4, or 8 of a postpartum follicular wave. ovaries of 61 beef cows were examined daily by transrectal ultrasonography starting at d 20 to 21 postpartum. treatments were no cr (n = 14) and cr on d 2 (n = 12), 4 (n = 16), or 8 (n ... | 2001 | 11721849 |
| high levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory. | the present study investigated the effects of high levels of estradiol in female rats on four different radial arm maze tasks: the hippocampus-dependent spatial working-reference memory task; the prefrontal cortex-hippocampus dependent delayed win-shift task; the striatum-dependent cued win-stay task; and the amygdala-dependent conditioned place preference task. ovariectomized female rats were injected daily with either 10 microg of estradiol benzoate or sesame oil vehicle approximately 4 h prio ... | 2001 | 11704257 |
| dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | the metabolism of tocotrienol remains unclear. we studied the distribution of tocotrienol in rats fed the tocotrienol-rich fraction extracted from palm oil. we have previously shown that dietary sesame seeds markedly elevate the tocopherol concentration in rats. in this study, we also examined the effect of dietary sesame seeds on the tocotrienol concentration. in experiment 1, rats (4-wk-old) were fed the diet with alpha-tocopherol alone or with alpha- and gamma-tocotrienols. in experiment 2, t ... | 2001 | 11694614 |
| in vivo inhibition of keratinocyte growth factor receptor expression by estrogen and antagonism by progesterone in the mouse mammary gland. | mammary gland development is regulated by complex interactions among mammogenic hormones and locally derived paracrine growth factors. in epithelial tissues, keratinocyte growth factor (kgf or fgf-7) originates in the stroma while its receptor (kgfr or fgfr2-iiib) is present only in the epithelium. previous work showed that estrogen but not progesterone could stimulate the synthesis of kgf in mammary stroma in vivo. the effects of 17 beta-estradiol and progesterone on kgfr expression in vivo wer ... | 2001 | 11691652 |
| determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs. | the rate of disappearance of clinically used vegetable oils, viscoleo, sesame oil, castor oil and isopropyl myristate, from the injection site after intramuscular (i.m.) or subcutaneous (s.c.) administration to pigs were determined by using a non-invasive gamma-scintigraphy method. all the oil vehicles were spiked with 2.5% (v/v) (125)i-triolein and six injections of 1.9 ml were given to each of 12 pigs. no significant difference (anova) in disappearance rate of each individual oil vehicle from ... | 2001 | 11672957 |
| effect of chronic treatment with haloperidol on vasopressin release and behavioral changes by osmotic stimulation of the supraoptic nucleus. | chronic treatment with dopamine d2 blockers in schizophrenic patients has been proposed as one of the causes of polydipsia and water intoxication, but this conclusion is still controversial. to investigate the relationship between dopamine d2 blockers and these syndromes, we designed a behavioral and neurochemical study using hyperosmotic stimulation in the supraoptic nucleus (son) by microdialysis after chronic treatment with haloperidol in rats. animals were injected with haloperidol decanoate ... | 2001 | 11669458 |
| effects of dietary sesame seeds on plasma tocopherol levels. | the tocopherols, the major vitamers of vitamin e, are believed to play a role in the prevention of human aging-related diseases such as cancer and heart disease, yet little is known concerning determinants of their plasma concentrations. evidence from animal studies suggests that the dietary source of gamma-tocopherol can significantly affect plasma levels of this tocopherol as well as its functional vitamin e activity. to determine whether plasma levels of tocopherols in humans are similarly al ... | 2001 | 11588904 |
| estradiol increases glucagon's satiating potency in ovariectomized rats. | estradiol decreases meal size, food intake, and body weight in female rats. to investigate whether these effects of estradiol involve a change in the sensitivity of the signaling pathway through which pancreatic glucagon released during meals contributes to meal termination (satiation), glucagon or glucagon antibodies were infused via the hepatic portal vein in ovariectomized rats that were chronically treated with estradiol benzoate (2 microg/day sc) or vehicle alone (100 microl sesame oil). in ... | 2001 | 11557638 |
| oxygen insertion in sesamum indicum furanofuran lignans. diastereoselective syntheses of enzyme substrate analogues. | the furofuran lignans in sesame seed have an unusual oxygen insertion between their furan and aryl rings. in our continuing investigations on the isolation and characterization of the enzyme(s) involved, the diastereoselective syntheses of various substrate analogues for the oxygen insertion step were developed for future substrate specificity and inhibitor studies. this synthetic strategy also provided entry to so-called furofuranone epoxy-lignans, such as salicifoliol from bupleurum sp., and a ... | 1997 | 11540412 |
| [teratogenicity study of 2,2,3,3,3-pentafluoro-1-propanol (5fp) in rats by oral administration]. | teratogenicity of 2,2,3,3,3-pentafluoro-1-propanol (5fp), an alternative cleaning agent for chlorofluorocarbon, was examined in rats. 5fp was diluted with sesame oil and given to pregnant rats (crj: wistar) by gavage once a day from day 7 to 17 of pregnancy at doses of 0, 250, 500 and 1000 mg/kg/day. the pregnant rats were sacrificed on day 20 of pregnancy and their fetuses were examined for malformation. in the pregnant rats, 5fp caused wheezing, salivation, ptosis, reduced body weight gain and ... | 2000 | 11534126 |
| effect of 7,12-dimethylbenz[a]anthracene (dmba) on gut glutathione metabolism. | one mechanism of the mammary carcinogenesis of 7,12-dimethylbenz[a]anthracene (dmba) is thought to be the generation of reactive oxygen species known to play an important role in initiation and progression. we hypothesized that dmba would disrupt gut glutathione (gsh) metabolism and this disruption would correlate with mammary cell carcinogenesis. | 2001 | 11516216 |
| potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (d4) and the linear siloxane hexamethyldisiloxane (hmds) in immature rats using the uterotrophic assay. | the cyclic siloxane octamethylcyclotetrasiloxane (d4) and the linear siloxane hexamethyldisiloxane (hmds) have numerous industrial and consumer applications and thus have the potential for human exposure. the present study was undertaken to examine potential estrogenic and antiestrogenic activities of d4 and hmds. to address potential differences in sensitivity between rat strains the study used both sprague-dawley (sd) and fischer 344 (f-344) rats. estrogenicity of the test compounds was determ ... | 2001 | 11509742 |